A penetration-enhancing composition and its preparation method and application

Abstract

The present invention discloses a penetration-enhancing composition, a preparation method thereof, and an application thereof, and relates to the field of cosmetic technology. The present invention provides a penetration-enhancing composition, comprising the following components in parts by weight: component A and component B, wherein component A comprises 1-5 parts by weight of Olivem 1000; component B comprises 0.5-3 parts by weight of Oliwax LC and 0.5-3 parts by weight of Surfinesse Cleanse G; the total mass ratio of component A to component A and component B is N, and N ≥ 0.4. The inventors found in actual experimental processes that when Olivem 1000, Oliwax LC, and Surfinesse Cleanse G are used in conjunction, the combination of the three functionally forms a multi-dimensional synergy of "emulsification + penetration enhancement + repair."

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, in particular to a penetration-enhancing composition and a preparation method and application thereof. Background Art

[0002] Human skin is the first biological barrier of the body. The unique "brick wall structure" of its stratum corneum makes it difficult for more than 90% of the active ingredients in cosmetics to achieve effective transdermal absorption. The current industry mainly uses four major technical systems: chemical penetration enhancement, nanocarriers, physical introduction and biological penetration enhancement to improve transdermal delivery efficiency. However, each technical route has significant application bottlenecks: (1) Chemical penetration enhancement technology: Although traditional penetration enhancers (such as azone, dimethyl sulfoxide, etc.) can improve permeability by changing the lipid arrangement of the stratum corneum, clinical studies have shown that when the added concentration is too high or the continuous use time is too long, the probability of inducing contact dermatitis is significantly increased. Long-term use can destroy the balance of skin microecology, leading to abnormal fluctuations in epidermal pH and downregulation of barrier protein FLG gene expression. (2) Nanocarrier technology: Although nanoemulsions, liposomes and other carriers have been developed (particle size distribution is mostly 50-200nm), there are two major technical barriers: first, the stability of nanomaterials in cosmetic matrices is insufficient; second, nanoparticles that are too small can penetrate the epidermis into the dermis, posing a potential risk of bioaccumulation. (3) Physical penetration enhancement technology: Although device-dependent technologies such as ion introduction and microneedles can improve skin penetration rates, they have problems such as complex operation, high cost, and invasive damage, making it difficult to meet the convenience needs of daily skin care scenarios. (4) Biological penetration enhancement technology: Although biomimetic carriers developed based on endogenous skin substances such as ceramides and cholesterol have excellent biocompatibility, current technologies have difficulty balancing the stability of amphiphilic structures: when the HLB value is controlled at 7-9, the phase transition temperature of the lipid bilayer will drop below 25°C, causing the carrier to disintegrate prematurely at room temperature; and the addition of stabilizers such as polysorbate will cause the risk of skin irritation.

[0003] In view of this, this application is filed. Summary of the Invention

[0004] Based on this, the purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art and provide a penetration-enhancing composition and its preparation method and application.

[0005] To achieve the above-mentioned objectives, in a first aspect of the present application, a penetration-enhancing composition is provided, comprising the following components in parts by weight: component A and component B; component A comprises 1-5 parts by weight of Olivem 1000; component B comprises: 0.5-3 parts by weight of Oliwax LC and 0.5-3 parts by weight of Surfinesse Cleanse G; the total mass ratio of component A to component A and component B is N, and N≥0.4.

[0006] During actual experiments, the inventors discovered that when Olivem 1000, Oliwax LC, and Surfinesse Cleanse G are used in conjunction, the combination of the three forms a multi-dimensional synergy of "emulsification + penetration enhancement + repair" in terms of function. On the one hand, the combined use of the above three components can reduce system stratification and improve centrifugal stability through the superposition and complementarity of liquid crystal structures; Olivem 1000 is an olive-derived liquid crystal emulsifier that can form a liquid crystal layered structure similar to the structure of the skin's stratum corneum, with excellent emulsification ability and stability; Surfinesse Cleanse G exhibits an emulsification effect with small, dense, and uniform droplets in the system; Oliwax LC, as an auxiliary emulsifier, can further improve the stability of the system by adjusting the liquid crystal arrangement. On the other hand, the combined use of these three components can improve the delivery efficiency of active ingredients; the liquid crystal structure of Olivem 1000 is similar to that of the skin's stratum corneum, which can promote the sustained release and penetration of active ingredients. Oliwax LC and Surfinesse Cleanse G, as auxiliary ingredients, can further improve the delivery efficiency of active ingredients by regulating interfacial tension and liquid crystal alignment. On the other hand, the combined use of these three components can repair damaged skin barriers and further reduce irritation reactions in sensitive skin. Olivem 1000 repairs damaged skin barriers by reducing the release of inflammatory factors and enhancing cell vitality. Combined with the stable emulsification system of Oliwax LC and Surfinesse Cleanse G, it further repairs damaged skin barriers.

[0007] As an embodiment of the present application, the component A includes 3-4 parts by weight of Olivem 1000; the component B includes 1-2 parts by weight of Oliwax LC and 1-2 parts by weight of Surfinesse Cleanse G.

[0008] As an implementation scheme of the present application, the N satisfies 0.6≤N≤0.7.

[0009] During actual experiments, the inventors found that when Olivem 1000, Oliwax LC, and Surfinesse Cleanse G are used in conjunction, the weight ratios of the three further affect the emulsification, penetration-enhancing, and repairing effects. When the weight ratios of the three are within the above-mentioned range, while ensuring system stability, the penetration-enhancing and repairing effects are better.

[0010] As an embodiment of the present application, the weight ratio of Oliwax LC to Surfinesse Cleanse G in component B is 1:1.

[0011] During actual experiments, the inventors found that the weight ratio of Oliwax LC and Surfinesse Cleanse G in component B further affects the emulsification, penetration-promoting and repairing effects. When the weight ratio of Oliwax LC and Surfinesse Cleanse G in component B is 1:1, the penetration-promoting and repairing effects are better while ensuring the stability of the system.

[0012] As an embodiment of the present application, the penetration-enhancing composition further includes 1-3 parts by weight of ergothioneine; and / or, the penetration-enhancing composition further includes 1-3 parts by weight of acetyl hexapeptide-8.

[0013] The inventors found in the actual experimental process that when the penetration-promoting composition further comprises ergothioneine and / or acetyl hexapeptide-8, the penetration-promoting and repairing effects of the system are better.

[0014] As an embodiment of the present application, the penetration-enhancing composition further includes 1.5-2.5 parts by weight of ergothioneine; and / or, the penetration-enhancing composition further includes 1.5-2.5 parts by weight of acetyl hexapeptide-8.

[0015] The inventors found in the actual experimental process that the weight portions of ergothioneine and acetyl hexapeptide-8 in the penetration-promoting composition further affect the effects of penetration promotion and repair. When the above weight portions are selected, the effects of penetration promotion and repair are better.

[0016] In one embodiment, the penetration-enhancing composition comprises ergothioneine and acetyl hexapeptide-8.

[0017] As an embodiment of the present application, the weight ratio of ergothioneine to acetyl hexapeptide-8 is 1:1.

[0018] The inventors found in the actual experimental process that when the penetration-promoting composition contains both ergothioneine and acetyl hexapeptide-8, it can better reflect the penetration-promoting and repairing effects in the system of Olivem 1000, Oliwax LC and Surfinesse Cleanse G.

[0019] In the second aspect of the present application, the present application provides the use of the penetration-enhancing composition in the preparation of skin products.

[0020] In a third aspect of the present application, the present application provides a skin product comprising the penetration-enhancing composition.

[0021] As an embodiment of the present application, the dosage form of the skin product is a lotion, emulsion, cream, gel, mask or essence.

[0022] As an embodiment of the present application, the skin product includes the following components in mass percentage: 1-5% of the penetration-enhancing composition, 2-30% of the cosmetic base, and the balance water; the cosmetic base includes at least one of a moisturizer, a thickener, a skin conditioner, an antioxidant, and an emollient.

[0023] In one embodiment, the present application provides a skin product comprising the following components in percentage by weight: 1-5% penetration enhancing composition, 1-10% moisturizer, 0.1-0.5% thickener, 0.05-1% skin conditioner, 0.5-1% antioxidant, 2-12% emollient, and the balance deionized water.

[0024] Exemplarily, the moisturizer includes at least one of glycerin, butylene glycol, low molecular weight sodium hyaluronate, and 1,2-hexanediol; the thickener includes at least one of xanthan gum, carbomer 980, high molecular weight cellulose, and polyacrylate crosspolymer-6; the skin conditioner includes at least one of trehalose, allantoin, and hyaluronic acid; the antioxidant includes at least one of tocopheryl acetate, parahydroxyacetophenone, and ascorbic acid; the emollient includes at least one of polydimethylsiloxane, shea butter (BUTYROSPERMUM PARKII) fruit butter, caprylic / capric triglyceride, petrolatum, and stearyl alcohol.

[0025] Compared with the prior art, the present invention has the following beneficial effects: when Olivem 1000, Oliwax LC and SurfinesseCleanse G are used in conjunction, the combination of the three forms a multi-dimensional synergy of "emulsification + penetration enhancement + repair" in terms of function. On the one hand, the combined use of the above three components can reduce system stratification and improve centrifugal stability through the superposition and complementarity of liquid crystal structures; Olivem 1000 is an olive-derived liquid crystal emulsifier that can form a liquid crystal layered structure similar to the structure of the skin's stratum corneum, and has excellent emulsification ability and stability; Surfinesse Cleanse G exhibits an emulsification effect with small, dense and uniform droplets in the system; Oliwax LC, as an auxiliary emulsifier, can further improve the stability of the system by adjusting the liquid crystal arrangement. On the other hand, the combined use of these three components can improve the delivery efficiency of active ingredients; the liquid crystal structure of Olivem 1000 is similar to that of the skin's stratum corneum, which can promote the sustained release and penetration of active ingredients. Oliwax LC and Surfinesse Cleanse G, as auxiliary ingredients, can further improve the delivery efficiency of active ingredients by regulating interfacial tension and liquid crystal alignment. On the other hand, the combined use of these three components can repair damaged skin barriers and further reduce irritation reactions in sensitive skin. Olivem 1000 repairs damaged skin barriers by reducing the release of inflammatory factors and enhancing cell viability. Combined with the stable emulsification system of Oliwax LC and Surfinesse Cleanse G, it further repairs damaged skin barriers. DETAILED DESCRIPTION

[0026] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below with reference to specific embodiments. Its purpose is to understand the content of the present invention in detail, rather than to limit the present invention. All other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. Unless otherwise specified, the experimental reagents and instruments designed for the implementation and comparative examples of the present invention are all commonly used ordinary reagents and instruments, which can be obtained from commercial channels. In the implementation and comparative examples, the experimental methods used are all conventional methods unless otherwise specified; and unless otherwise specified, the raw materials used in parallel experiments are the same batch of raw materials.

[0027] The raw materials used in the present invention are described below, but are not limited to the following raw materials:

[0028] Olivem 1000: available from HALLSTAR BEAUTY, INCI: Cetearyl Olivate, Sorbitan Olivate;

[0029] Oliwax LC: available from HALLSTAR BEAUTY, INCI: Cetyl Palmitate, Sorbitan Palmitate, and Sorbitan Olivate;

[0030] Surfinesse Cleanse G: HALLSTAR BEAUTY, INCI: Polyglyceryl-4 Oleate (and) Ethyl Olivate;

[0031] Ergothioneine, acetyl hexapeptide-8, etc. are all conventional commercially available products.

[0032] Olivem 2020G: Purchased from HALLSTAR BEAUTY, INCI: Ethylhexyl Olivate, Sodium Acrylates Copolymer, Polyglyceryl-4 Oleate;

[0033] Olivem 700: available from HALLSTAR BEAUTY, INCI: PEG-4 Olivate;

[0034] Montanov 202: French Seppic, INCI: Arachidyl Alcohol, Behenyl Alcohol, Arachidyl Glucoside.

[0035] Examples and Comparative Examples

[0036] The present application provides a penetration-enhancing composition. The components and weight portions of the penetration-enhancing compositions of the Examples and Comparative Examples are shown in Tables 1-2 below. The penetration-enhancing composition is prepared by uniformly mixing all the components to obtain the composition. When preparing the comparative example composition, if the relevant components are not present, then no relevant components are added. If other components are present, they are also added together and mixed uniformly.

[0037] Table 1

[0038]

[0039] Table 2

[0040]

[0041]

[0042] Application Examples

[0043] Application Examples 1-13 and Comparative Application Examples 1-7 of the present invention provide an emulsion, the components (mass percentages) of the emulsion are shown in Table 3; wherein the penetration-enhancing compositions in Application Examples 1-12 are the penetration-enhancing compositions prepared in Examples 1-12, and the penetration-enhancing compositions in Comparative Application Examples 1-7 are the penetration-enhancing compositions prepared in Comparative Examples 1-7; for example, the penetration-enhancing composition used in Application Example 1 is the penetration-enhancing composition prepared in Example 1, the penetration-enhancing composition used in Application Example 2 is the penetration-enhancing composition prepared in Example 2, the penetration-enhancing composition used in Comparative Application Example 1 is the penetration-enhancing composition prepared in Comparative Example 1, and the like can be deduced. The penetration-enhancing composition used in Application Example 13 is the penetration-enhancing composition prepared in Example 6.

[0044] Table 3

[0045]

[0046]

[0047] The preparation method of the emulsion comprises the following steps:

[0048] (1) Component A is mixed with water, heated to 80°C, and homogenized at 1200 rpm for 5 minutes. After homogenization, the mixture is kept warm for later use to obtain prefabricated component A;

[0049] (2) Mix component B, heat to 80°C, and homogenize at 1200 rpm for 5 minutes. After homogenization, keep warm and set aside to obtain prefabricated component B;

[0050] (3) Mix the C components and heat to 60°C to melt to obtain a prefabricated C component;

[0051] (4) The prefabricated component A was heated to 80°C, and the prefabricated component B was added at a speed of 300 rpm, and stirred and mixed. Then, the temperature was lowered to 60°C, and the prefabricated component C was added at a speed of 300 rpm, and stirred and mixed. Then, the temperature was lowered and the material was discharged to obtain an emulsion.

[0052] Performance Test-1 Stability Test

[0053] The emulsions prepared in the application examples and comparative application examples were subjected to stability tests. The heat resistance test involved standing at 48°C for three months and observing their appearance, color, and odor. The cold resistance test involved standing at -18°C for three months and observing their appearance, color, and odor. The room temperature test involved standing at 25°C for three months and observing their appearance, color, and odor. The hot and cold cycling test involved standing at 45°C, room temperature, and -18°C for 24 hours each, for 10 cycles, and observing their appearance, color, and odor. The test results are shown in Table 4.

[0054] Table 4

[0055]

[0056]

[0057] It can be seen from the above table that the emulsions prepared in the application examples of the present invention and the comparative application examples have excellent stability.

[0058] Performance Test-2 Penetration Test

[0059] Taking retinol as the target active ingredient, the compositions prepared in Examples 1-12 and Comparative Examples 1-7 were diluted with deionized water to a mass percentage of 3%, and then formulated with retinol at a ratio of 95:5 to prepare the test substance. In this way, the penetration-enhancing effect of the penetration-enhancing compositions of the Examples and Comparative Examples was examined.

[0060] A pigskin-Franzcell permeation diffusion cell test was conducted (the instrument was a TK transdermal absorption tester, and the instrument operation method can be referred to), with reference to the national standard GBT27818-2011.

[0061] The specific method is as follows: remove hair and subcutaneous tissue from fresh pig back skin, clean it, dry it and cut it into suitable sizes for later use. The pig back skin comes from a slaughterhouse. Fix the pig back skin between the supply chamber and the receiving chamber of a TK-type transdermal absorption tester. The receiving liquid is an isotonic PBS buffer solution. The test liquids are the compositions of the embodiment and the comparative example, respectively. Five groups of samples are tested in parallel, and the average value is taken. The transdermal test is performed in a 37°C circulating water bath. Take 0.5 mL of sample at 4h and 12h after the start of the test, and add 0.5 mL of PBS after sampling. The sample is filtered through a 0.22μm filter membrane and used as a test sample. The diffusion percentage of retinol in the 4h and 12h samples is detected and calculated respectively.

[0062] Among them, the content of retinol was tested using the determination method of "Guangdong Cosmetics Association Group Standard T / GDCA 005-2021 Retinol, Retinol Acetate, Retinol Palmitate, and Hydroxypinacolone Retinoate in Cosmetics".

[0063] The test results are shown in Table 5.

[0064] Table 5

[0065] Case 4h Retinol diffusion percentage / % 12h retinol diffusion percentage / % Example 1 22.78 32.19 Example 2 22.47 32.00 Example 3 20.05 30.21 Example 4 20.56 30.38 Example 5 20.64 30.55 Example 6 26.65 36.76 Example 7 24.12 33.82 Example 8 27.37 38.21 Example 9 27.45 38.19 Example 10 30.85 42.78 Example 11 29.35 41.05 Example 12 29.32 41.28 Comparative Example 1 5.33 5.65 Comparative Example 2 7.53 8.65 Comparative Example 3 8.42 8.72 Comparative Example 4 5.36 5.84 Comparative Example 5 5.33 5.81 Comparative Example 6 8.21 8.96 Comparative Example 7 7.83 8.20

[0066] It can be seen from the above table that the penetration-enhancing composition prepared in the examples of the present invention has an excellent penetration-enhancing effect and can effectively promote the penetration of active ingredients.

[0067] From the comparison of Examples 1-7, it can be seen that when Olivem 1000, Oliwax LC and Surfinesse Cleanse G are used synergistically in the penetration-enhancing composition, the weight proportions of the three will affect the final penetration-enhancing effect. When the component A comprises the following components in weight: 3-4 parts of Olivem 1000; and the component B comprises the following components in weight: 1-2 parts of Oliwax LC and 1-2 parts of Surfinesse Cleanse G, the penetration-enhancing effect is better.

[0068] From the comparison of Examples 1-7, it can be seen that when the ratio of the weight of component A to the total weight of component A and component B in the penetration-enhancing composition is ≥0.6, the penetration-enhancing effect is better.

[0069] From the comparison of Examples 1-7, it can be seen that when the weight ratio of Oliwax LC and SurfinesseCleanse G in component B of the penetration-enhancing composition is 1:1, the penetration-enhancing effect is better.

[0070] From the comparison of Example 6 and Example 8-12, it can be seen that when the penetration-promoting composition further comprises ergothioneine and / or acetyl hexapeptide-8, the penetration-promoting effect of the system is better.

[0071] By comparison of Examples 8-9 and 10-12, it can be seen that when the penetration-enhancing composition contains both ergothioneine and acetyl hexapeptide-8, the penetration-enhancing effect can be better reflected in the system of Olivem 1000, Oliwax LC and Surfinesse Cleanse G.

[0072] Compared with Example 6, Comparative Examples 1-3 lacked one of Olivem 1000, Oliwax LC, and Surfinesse Cleanse G. The results showed that the penetration-enhancing effect was extremely poor. Olivem 1000, Oliwax LC, and Surfinesse Cleanse G are all indispensable in the penetration-enhancing composition of the present invention. Comparative Examples 4-6, compared with Example 6, replaced one of Olivem 1000, Oliwax LC, and Surfinesse Cleanse G with other raw materials. The results showed that the penetration-enhancing effect was extremely poor. Olivem 1000, Oliwax LC, and Surfinesse Cleanse G are irreplaceable in the penetration-enhancing composition of the present invention. Comparative Example 7, compared with Example 6, had a total mass ratio of Component A to Component A and Component B of less than 0.4. The results showed that the penetration-enhancing effect was extremely poor. The weight ratios of Olivem 1000, Oliwax LC, and Surfinesse Cleanse G in the penetration-enhancing composition of the present invention need to be within a specific range to achieve a good penetration-enhancing effect.

[0073] Performance Test-3

[0074] The effectiveness examples of the present invention verify the safety performance of the products prepared by application examples 1-13 and comparative application examples 1-7.

[0075] Thirty volunteers (15 men and 15 women, aged 20-50 years) were recruited for a closed patch test. Equal amounts (0.020 mL to 0.025 mL) of the test sample were placed in a specific patch tester. The patch was then applied to the volunteer's arm with hypoallergenic tape, gently pressed to evenly adhere to the skin, and left for 24 hours. A blank control group received distilled water. After 24 hours, the patch tester was removed, and skin reactions were observed 0.5, 24, and 48 hours later, with the results recorded. The severity of adverse skin reactions is shown in Table 6 below.

[0076] Table 6

[0077]

[0078]

[0079] After testing, the emulsions provided by the application examples of the present invention and the comparative application examples all showed negative reactions after human patch tests, and were safe and non-irritating to human skin.

[0080] Performance Test-4

[0081] The effect examples of the present invention verify the repair performance of the products prepared by the application examples and comparative application examples.

[0082] The test process is as follows: volunteers aged 18-45 were selected. No skin care products were applied on the day of the visit. After washing their faces, the subjects sat quietly in a constant temperature and humidity room at 21±1℃ and 50±10% for 30 minutes. The transepidermal water loss probe was used to measure the skin's The TM Hex (Courage + Khazaka) test measures initial facial TEWL values. Subjects were randomly divided into 20 groups, each with 5 participants. The application example and comparison example products were randomly applied to the entire face. TEWL testing and Visia-7 photography were performed on days 7 and 14. TEWL improvements were analyzed at days 0, 7, and 14. The improvement was expressed as the improvement rate for each value, calculated as follows:

[0083] Improvement rate relative to the initial value = (X 使用前 -X 使用后 ) / X 使用前 ×100%;

[0084] The transepidermal water loss TEWL value is a commonly used indicator reflecting the barrier function of the stratum corneum. The lower the TEWL value, the better the skin barrier function and the better the repair effect of the product.

[0085] The test results are shown in Table 7;

[0086] Table 7

[0087]

[0088]

[0089] As can be seen from the above table, when the penetration-enhancing composition prepared in the examples of the present invention is applied to the emulsion formula, it can repair the damaged skin barrier and further reduce the irritation reaction of sensitive skin.

[0090] From the comparison of Examples 1-7, it can be seen that when Olivem 1000, Oliwax LC, and Surfinesse Cleanse G are used synergistically in the penetration-enhancing composition, the weight proportions of the three will affect the final repair effect. When component A comprises the following components in weight: 3-4 parts of Olivem 1000; and component B comprises the following components in weight: 1-2 parts of Oliwax LC and 1-2 parts of Surfinesse Cleanse G, the repair effect is better.

[0091] From the comparison of Examples 1-7, it can be seen that when the ratio of the weight of component A to the total weight of component A and component B in the penetration-enhancing composition is ≥0.6, the repair effect is better.

[0092] From the comparison of Examples 1-7, it can be seen that when the weight ratio of Oliwax LC and SurfinesseCleanse G in component B of the penetration-enhancing composition is 1:1, the repairing effect is better.

[0093] From the comparison of Example 6 and Examples 8-12, it can be seen that when the penetration-promoting composition further comprises ergothioneine and / or acetyl hexapeptide-8, the repair effect of the system is better.

[0094] From the comparison of Examples 8-9 and Examples 10-12, it can be seen that when the penetration-enhancing composition contains both ergothioneine and acetyl hexapeptide-8, the repair effect can be better reflected in the system of Olivem 1000, Oliwax LC and Surfinesse Cleanse G.

[0095] Compared with Example 6, Comparative Examples 1-3 lacked one of Olivem 1000, Oliwax LC, and Surfinesse Cleanse G. The results showed that the repair effect was extremely poor, indicating that Olivem 1000, Oliwax LC, and Surfinesse Cleanse G are all indispensable in the penetration-enhancing composition of the present invention. Comparative Examples 4-6, compared with Example 6, replaced one of Olivem 1000, Oliwax LC, and Surfinesse Cleanse G with other raw materials. The results showed that the repair effect was extremely poor, indicating that Olivem 1000, Oliwax LC, and Surfinesse Cleanse G are irreplaceable in the penetration-enhancing composition of the present invention. Comparative Example 7, compared with Example 6, had a mass ratio of Component A to the total mass of Component A and Component B of less than 0.4. The results showed that the penetration-enhancing effect was extremely poor, indicating that the weight ratios of Olivem 1000, Oliwax LC, and Surfinesse Cleanse G in the penetration-enhancing composition of the present invention must be within a specific range to achieve a good repair effect.

[0096] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A penetration-enhancing composition, characterized in that The invention comprises the following components in parts by weight: component A and component B; The component A comprises 1-5 parts by weight of Olivem 1000; The component B comprises: 0.5-3 parts by weight of Oliwax LC and 0.5-3 parts by weight of Surfinesse Cleanse G; The total mass ratio of component A to component A and component B is N, and N is greater than or equal to 0.

4.

2. The penetration-enhancing composition according to claim 1, wherein The component A comprises 3-4 parts by weight of Olivem 1000; The component B includes 1-2 parts by weight of Oliwax LC and 1-2 parts by weight of Surfinesse Cleanse G.

3. The penetration-enhancing composition according to claim 1, wherein The N satisfies 0.6≤N≤0.

7.

4. The penetration-promoting composition according to claim 1, wherein The weight ratio of Oliwax LC to SurfinesseCleanse G in component B is 1:

1.

5. The penetration-enhancing composition according to claim 1, wherein Also comprising 1-3 parts by weight of ergothioneine; And / or, the penetration-enhancing composition further comprises 1-3 parts by weight of acetyl hexapeptide-8.

6. The penetration-enhancing composition according to claim 5, wherein Also comprising 1.5-2.5 weight portions of ergothioneine; And / or, the penetration-enhancing composition further comprises 1.5-2.5 parts by weight of acetyl hexapeptide-8.

7. The penetration-promoting composition according to claim 5 or 6, wherein The weight ratio of the ergothioneine to acetyl hexapeptide-8 is 1:

1.

8. Use of the penetration-enhancing composition according to any one of claims 1 to 7 in the preparation of skin products.

9. A skin care product, characterized in that: The skin product comprises the penetration-enhancing composition according to any one of claims 1 to 7.

10. The skin care product according to claim 9, wherein The skin care product comprises the following components in percentage by weight: 1-5% of the penetration-enhancing composition according to any one of claims 1 to 7, 2-30% of a cosmetic base, and the balance being water; the cosmetic base comprising at least one of a moisturizer, a thickener, a skin conditioner, an antioxidant, and an emollient.

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