Antioxidant coenzyme Q10 capsule and preparation method thereof

Abstract

The invention discloses an antioxidant coenzyme Q10 capsule and a preparation method thereof, and belongs to the field of health care products. The coenzyme Q10 capsule contains an antioxidant composition, and the composition is composed of coenzyme Q10, a humifuse euphorbia herb extract, a shaddock peel extract and a Chinese wampee fruit extract. The coenzyme Q10, the humifuse euphorbia herb extract, the shaddock peel extract and the Chinese wampee fruit extract are compounded for use and have a synergistic effect, so that an excellent anti-oxidation effect is obtained.

Description

Technical Field

[0001] The present invention relates to the field of health products, and particularly to an antioxidant coenzyme Q10 capsule and a preparation method thereof. Background Art

[0002] Coenzyme Q10 itself is a fat-soluble quinone compound existing in nature. Its structure is similar to that of vitamin K, vitamin E, and plastoquinone. It participates in energy production and activation in human cells and is the most effective antioxidant component for preventing the formation of arteriosclerosis. Coenzyme Q10 mainly has two functions in the body: one is to play an important role in the process of converting nutrients into energy in mitochondria, and the other is to have an obvious anti-lipid peroxidation effect. However, with the increase of age, the ability of the human body to synthesize coenzyme Q10 autonomously will gradually decline. Therefore, supplementing with coenzyme Q10 capsules can effectively improve human immunity, enhance antioxidant ability, delay aging, and enhance human vitality.

[0003] Although coenzyme Q10 has a significant antioxidant effect, it has some disadvantages, such as low absorption rate in the body, and its antioxidant effect is mainly concentrated in the cell mitochondria, and the antioxidant effect on the outside of the cell is limited. And flavonoids, phenols, and terpenoids in plant extracts have strong antioxidant effects and high absorption rates. Therefore, it is necessary to provide a composition containing coenzyme Q10 and plant extracts, and use the combined action of coenzyme Q10 and plant extracts to synergistically achieve a more excellent antioxidant effect. Summary of the Invention

[0004] The purpose of the present invention is to provide an antioxidant coenzyme Q10 capsule and a preparation method thereof. The capsule contains an antioxidant composition, and the antioxidant composition is prepared from coenzyme Q10, Euphorbia humifusa extract, pomelo peel extract, and wampee fruit extract as raw materials, and has an excellent antioxidant effect.

[0005] In order to achieve the above purpose, the present invention adopts the following technical solutions:

[0006] In the first aspect, the present invention provides an antioxidant composition, including the following components: coenzyme Q10, Euphorbia humifusa extract, pomelo peel extract, and wampee fruit extract.

[0007] The antioxidant composition includes the following raw materials in parts by mass:

[0008] Coenzyme Q10: 3 - 5 parts;

[0009] Euphorbia humifusa extract: 10 - 15 parts;

[0010] Pomelo peel extract: 20 - 25 parts;

[0011] Wampee fruit extract: 30 - 50 parts.

[0012] Furthermore, the antioxidant composition comprises raw materials in the following parts by mass:

[0013] Coenzyme Q10: 4 - 5 parts;

[0014] Euphorbia humifusa extract: 10 - 13 parts;

[0015] Pomelo peel extract: 20 - 23 parts;

[0016] Wampee fruit extract: 40 - 50 parts.

[0017] Most preferably, the antioxidant composition comprises raw materials in the following parts by mass:

[0018] Coenzyme Q10: 4 parts;

[0019] Euphorbia humifusa extract: 13 parts;

[0020] Pomelo peel extract: 23 parts;

[0021] Wampee fruit extract: 40 parts.

[0022] In a second aspect, the present invention provides an antioxidant coenzyme Q10 capsule, which comprises capsule contents and a capsule shell. The capsule contents comprise the following components in mass percentage:

[0023] The antioxidant composition described in the first aspect: 50 - 70 wt%;

[0024] Make up to 100 wt% with drinking water.

[0025] Preferably, the capsule shell is one of a soft capsule shell and a hard capsule shell.

[0026] More preferably, the capsule shell is a soft capsule shell.

[0027] In a third aspect, the present invention provides a preparation method of the antioxidant coenzyme Q10 capsule described in the second aspect. The preparation method comprises the following steps:

[0028] S1: Mix the Euphorbia humifusa extract, pomelo peel extract, wampee fruit extract with half of the drinking water to obtain a mixed solution A;

[0029] S2: Mix coenzyme Q10 with the remaining drinking water to obtain a mixed solution B;

[0030] S3: Mix the mixed solution A and the mixed solution B, and perform ultrasonic oscillation to obtain the capsule contents;

[0031] S4: Place the capsule contents in a fully automatic soft capsule machine to prepare a soft capsule preparation, sterilize the soft capsule preparation, seal it, and store it in the dark at room temperature.

[0032] Compared with the prior art, the beneficial effects of the present invention are as follows: the present invention provides an antioxidant coenzyme Q10 capsule and a preparation method thereof, the capsule comprising an antioxidant composition, the antioxidant composition being compounded by coenzyme Q10, Herba Euphorbiae Extract, Citrus Grandis Peel Extract and Phellodendron Fruit Extract, and studies have found that there is a synergistic effect between coenzyme Q10 and Herba Euphorbiae Extract, Citrus Grandis Peel Extract and Phellodendron Fruit Extract, specifically: on the one hand, Herba Euphorbiae Extract, Citrus Grandis Peel Extract and Phellodendron Fruit Extract are rich in a variety of flavonoids and polyphenols and terpenoids, which can act in different pathways and jointly exert an antioxidant effect, and on the other hand, coenzyme Q10 has excellent electron transfer and free radical scavenging effects, and it synergizes with the polyphenols and flavonoids in Herba Euphorbiae Extract, Citrus Grandis Peel Extract and Phellodendron Fruit Extract, complements each other in the antioxidant mechanism, and jointly improves the antioxidant effect. DETAILED DESCRIPTION

[0033] In order to better understand the present invention, the present invention is further described below in conjunction with specific application examples, wherein the terms used in the application examples are for describing specific implementation schemes and do not constitute limitations on the protection scope of the present invention.

[0034] The experimental methods in the following examples without specifying specific conditions are usually carried out under conventional conditions or conditions recommended by the manufacturer. Unless otherwise specified, the calculation is based on mass percentage and mass fraction.

[0035] Some raw materials and their sources are as follows:

[0036] Coenzyme Q10: purchased from Shandong Huiheng Biotechnology Co., Ltd.;

[0037] Euphorbia euphorbia extract: purchased from Shanyang Lianfeng Biotechnology Co., Ltd.;

[0038] Grapefruit peel extract: purchased from Guangdong Mingcheng Biotechnology Co., Ltd.;

[0039] Phellodendron chinense fruit extract: purchased from Ningxia Vanilla Biotechnology Co., Ltd.

[0040] Fully automatic soft capsule machine: ZTHT-125 fully automatic soft capsule machine, purchased from Beijing Zhongtian Huitong Technology Co., Ltd.

[0041] The components of the antioxidant composition and their weight ratios are shown in Table 1.

[0042] Table 1 Components of the antioxidant composition and their mass ratios

[0043]

[0044]

[0045] The components and their mass percentages of the antioxidant coenzyme Q10 capsules are shown in Table 2.

[0046] Table 2 Components and mass percentages of antioxidant coenzyme Q10 capsules

[0047]

[0048] The preparation methods of the above application examples 1-5 are as follows:

[0049] S1: Mix the Herba Euphorbiae Ichthyophthirii extract, the Citrus Grandis peel extract, the Phellodendron chinense fruit extract and half of the drinking water to obtain a mixed solution A;

[0050] S2: Mix the coenzyme Q10 and the remaining drinking water to obtain a mixed solution B;

[0051] S3: Mixing the mixed solution A and the mixed solution B, and performing ultrasonic oscillation to obtain capsule contents, wherein the ultrasonic oscillation frequency is 60 kHz and the ultrasonic time is 5 min;

[0052] S4: placing the capsule contents in a fully automatic soft capsule machine to prepare a capsule preparation, sterilizing the capsule preparation, sealing it, and storing it at room temperature away from light.

[0053] Among them, the capsule preparation described in S4 is a gelatin soft capsule preparation, and the gelatin soft capsule shell is made of gelatin, glycerin and water in a mass ratio of 1:0.35:0.8.

[0054] Antioxidant assay

[0055] Experiment 1: Antioxidant test in mice

[0056] Healthy adult KM mice weighing 20-30 g were selected and adaptively fed for 5 days. According to the experimental requirements, they were divided into 1 normal control group, 1 model control group, and 10 sample groups, with 9 mice in each group. The model control group and the sample group used modeling mice, and the normal control group used normal mice.

[0057] Sample concentration: Compositions 1-3, ①-⑦ were prepared with drinking water to form a 60 wt% sample solution.

[0058] Modeling method: The model was established by referring to the D-galactose oxidative damage model specified in the National Food and Drug Administration's Antioxidant Function Evaluation Method (2012) No. 107.

[0059] Instillation concentration: Mice were fed with ten times the daily dose of 8.33 mg / kg for adults (60 kg). The feeding dose for mice was 0.75 g / kg, once a day for 3 days. The dose conversion factor between mice and humans was 9.01.

[0060] Experimental method: The model mice were gavaged with 0.75g / kg sample drugs, and the model control group and the blank control group were gavaged with the same volume of drinking water. After the feeding was completed, the tail venous blood of the mice was taken to detect the MDA and SOD indicators. The test results are shown in Table 3.

[0061] Test 2: In vitro antioxidant test

[0062] Test sample concentration: Compositions 1-3, ①-⑦ were prepared with drinking water to form a 60 wt % sample solution.

[0063] Positive control group: Vitamin C, prepared in drinking water at 0.03 mg / mL.

[0064] Test method: Refer to the test kit instructions.

[0065] Kit used: Total antioxidant capacity (DPPH method) test kit was purchased from Shanghai ELISA Biotechnology Co., Ltd., catalog number ml092650. The test results are shown in Table 3.

[0066] Table 3 Antioxidant test results

[0067]

[0068] Note: “#” indicates comparison with the model control group, p < 0.05; “*” indicates comparison with the blank control group, p < 0.05; “a” indicates comparison with the composition 1, p < 0.05; “b” indicates comparison with the positive control group, p < 0.05; “-” indicates blank.

[0069] Result analysis:

[0070] 1. Analysis of the results of the mouse antioxidant test

[0071] Comparison of the results of compositions 1-3 and the model control group shows that the antioxidant composition of the present invention has significant antioxidant efficacy.

[0072] Comparing the results of composition 1 with compositions ①-④, it can be seen that there is a significant synergistic effect among coenzyme Q10, Euphorbia euphorbia extract, Citrus grandis peel extract, and Phellodendron chinense fruit extract in the present invention.

[0073] By comparing the results of composition 1 with compositions ⑤-⑦, it can be seen that within the dosage range specified in the present invention, there is a significant synergistic effect between coenzyme Q10, Euphorbia euphorbia extract, Citrus grandis peel extract, and Phellodendron chinense fruit extract.

[0074] 2. Analysis of in vitro antioxidant test results

[0075] Comparing the results of compositions 1-3 with the positive control group, it can be seen that the antioxidant composition of the present invention has significant antioxidant efficacy.

[0076] Comparing the results of composition 1 with compositions ①-④, it can be seen that there is a significant synergistic effect among coenzyme Q10, Euphorbia euphorbia extract, Citrus grandis peel extract, and Phellodendron chinense fruit extract in the present invention.

[0077] By comparing the results of composition 1 with compositions ⑤-⑦, it can be seen that within the dosage range specified in the present invention, there is a significant synergistic effect between coenzyme Q10, Euphorbia euphorbia extract, Citrus grandis peel extract, and Phellodendron chinense fruit extract.

[0078] The embodiments described above are part of the embodiments of the present invention, rather than all of the embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention claimed for protection, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present invention.

Claims

1. An antioxidant composition, characterized in that The composition comprises the following raw materials in parts by weight: Coenzyme Q10: 3-5 parts; Euphorbia euphorbia extract: 10-15 parts; Grapefruit peel extract: 20-25 parts; Phellodendron chinense fruit extract: 30-50 parts.

2. The composition according to claim 1, characterized in that The composition comprises the following raw materials in parts by weight: Coenzyme Q10: 4 parts; Euphorbia pulegiae extract: 13 parts; Grapefruit peel extract: 23 parts; Phellodendron chinense fruit extract: 40 parts.

3. Use of the antioxidant composition according to claim 1 or 2 in the preparation of health products.

4. The use according to claim 3, characterized in that: The health product is an antioxidant product.

5. An antioxidant product as claimed in claim 4, characterized in that: The dosage form of the antioxidant product is any one of capsules, tablets and oral liquid.

6. An antioxidant coenzyme Q10 capsule, characterized in that: The capsule comprises capsule contents and a capsule shell, and the capsule contents comprise the following components in mass percentage: The antioxidant composition of claim 1 or 2: 50-70 wt %; Drinking water was added to make up to 100 wt%.

7. A method for preparing the antioxidant coenzyme Q10 capsule according to claim 6, characterized in that: The preparation method comprises the following steps: S1: Mix the Herba Euphorbiae Ichthyophthirii extract, the Citrus Grandis peel extract, the Phellodendron chinense fruit extract and 1 / 2 drinking water to obtain a mixed solution A; S2: Mixing coenzyme Q10 and remaining drinking water to obtain a mixed solution B; S3: Mixing the mixed solution A and the mixed solution B, and ultrasonically shaking to obtain capsule contents; S4: placing the capsule contents in a fully automatic soft capsule machine to prepare a soft capsule preparation, sterilizing the soft capsule preparation, sealing it, and storing it at room temperature away from light.

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