Anti-inflammatory composition containing basil extract and preparation method of anti-inflammatory composition

Abstract

The invention relates to an anti-inflammatory composition containing a basil extract and a preparation method of the anti-inflammatory composition, and belongs to the technical field of anti-inflammatory compositions. The anti-inflammatory composition containing the basil extract is prepared from the following components: an anti-inflammatory compound, a humectant, an emulsifier, an anti-allergic agent, a thickening agent and deionized water, the preparation method comprises the following steps: adding the anti-allergy agent, the humectant, the emulsifier and the thickener into the deionized water, uniformly mixing, then adding the anti-inflammatory compound, and uniformly mixing, thereby obtaining the anti-allergy anti-inflammatory cream. According to the invention, various natural components are compounded to form different anti-oxidation mechanisms and a mutual synergistic antibacterial mechanism, and from the angles of oxidation resistance, bacteria resistance, moisturizing performance, analgesia and the like, the soothing and anti-inflammation effects are achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of anti-inflammatory compositions, and relates to an anti-inflammatory composition containing a basil extract and a preparation method thereof. Background Art

[0002] Dryness, peeling, redness and swelling on the face indicate that the stratum corneum of the skin has become weak and the protective barrier function has weakened. Once the barrier function is damaged, the skin's ability to retain moisture will decrease, causing dryness and peeling, and the skin's sensitivity will increase, making it prone to inflammation, erythema and itching.

[0003] Basil essential oil contains a variety of chemical components, the main components of which are mainly classified as alcohols, phenols and terpenes. Modern medical research and clinical trials have shown that the essential oil has pharmacological effects such as antibacterial, antifungal, antioxidant, anti-inflammatory, pain relief, anthelmintic and relaxation of intestinal smooth muscle. Therefore, it shows potential application potential and huge market potential in the treatment of digestive system and skin inflammatory system diseases.

[0004] The extraction of basil essential oil, the active ingredient of basil, is generally carried out by steam distillation; steam distillation refers to the extraction method of volatile components by distilling raw materials with water, so that the volatile components are distilled out together with the water vapor, and the volatile components are obtained after condensation. During the operation of steam distillation, the raw materials are kept at high temperature for a long time, which can easily lead to the decomposition of some heat-sensitive components in the essential oil. Summary of the invention

[0005] The purpose of the present invention is to provide an anti-inflammatory composition containing basil extract and a preparation method thereof. The present invention forms different antioxidant mechanisms and mutually synergistic antibacterial mechanisms through the combination of multiple natural ingredients, and plays a soothing and anti-inflammatory role from the perspectives of antioxidant, antibacterial, moisturizing, analgesic, etc.

[0006] The purpose of the present invention can be achieved through the following technical solutions:

[0007] An anti-inflammatory composition containing basil extract comprises the following components by weight: 40-52 parts of anti-inflammatory compound, 1-2 parts of moisturizer, 0.2-0.3 parts of emulsifier, 0.06-0.08 parts of anti-allergic agent, 0.03-0.05 parts of thickener and 110-120 parts of deionized water.

[0008] As a preferred technical solution of the present invention, the moisturizing agent is one or more of glycerin, hydroxyethyl urea, D-panthenol, propylene glycol, butylene glycol, betaine, hyaluronic acid and sodium hyaluronate.

[0009] As a preferred technical solution of the present invention, the emulsifier is one or more of glycerol stearate, sucrose stearate and sucrose palmitate.

[0010] As a preferred technical solution of the present invention, the anti-allergic agent is one or more of dipotassium glycyrrhizinate and ectoine.

[0011] As a preferred technical solution of the present invention, the thickener is one or more of hydroxyethyl cellulose, xanthan gum and carbomer.

[0012] As a preferred technical solution of the present invention, the method for preparing the anti-inflammatory complex comprises the following steps:

[0013] S1, drying basil leaves and perilla leaves, grinding and sieving to obtain a mixed powder, mixing the mixed powder, rectorite and deionized water, adding the mixed powder to an extraction tank after ultrasonic treatment, extracting by steam distillation, collecting essential oil after distillation, and dehydrating with anhydrous sodium sulfate to obtain a composite extract;

[0014] S2. Under a nitrogen environment, p-hydroxycinnamaldehyde, wheat germ extract and composite extract are placed in anhydrous ethanol and stirred to mix, carboxymethyl chitosan solution is added and stirred at a constant temperature, the supernatant is removed by centrifugation, and the mixture is freeze-dried to obtain the product.

[0015] As a preferred technical solution of the present invention, in step S1, the screening is through a 40-60 mesh sieve; the ultrasonic treatment is ultrasonic treatment at a power of 180-220 W for 15-20 min; the extraction parameters are distillation at a temperature of 58-70°C for 5-7h; the mass ratio of the basil leaves to the perilla leaves is 1:0.6-0.8; the mass ratio of the mixed powder, rectorite and deionized water is 2:0.6-0.8:15-18.

[0016] As a preferred technical solution of the present invention, in step S1, the ultrasonic treatment technology has the ability to heat rapidly and evenly, which can destroy the cell membrane in a short time and accelerate the dissolution and penetration of the active ingredients. This allows the active ingredients in basil and perilla to be released quickly, and the content of the active ingredients is increased; rectorite not only helps release the active ingredients, but also adsorbs these active organic molecules and gas molecules to prevent them from being damaged by long-term exposure to high temperatures.

[0017] As a preferred technical solution of the present invention, in step S2, the stirring and mixing is stirring at a temperature of 40-50°C and a speed of 500-600rpm for 30-40min; the constant temperature stirring is stirring at a temperature of 60-70°C for 4-5h; the mass ratio of the p-hydroxycinnamaldehyde, wheat germ extract, composite extract, anhydrous ethanol and carboxymethyl chitosan solution is 4.2-5.0:6.2-6.6:2.8-3.3:70-80:100-110; the carboxymethyl chitosan solution is formed by mixing carboxymethyl chitosan and deionized water in a mass ratio of 1.0-1.2:22-25.

[0018] As a preferred technical solution of the present invention, the preparation method of the wheat germ extract comprises the following steps: mixing wheat germ powder and n-hexane for extraction, centrifuging to obtain the supernatant, rotary evaporating to remove the solvent, and vacuum drying to obtain the extract.

[0019] As a preferred technical solution of the present invention, in the preparation of the wheat germ extract, the usage ratio of the wheat germ powder and n-hexane is 11-12g:52-60mL; the extraction conditions are extraction at 40-45°C for 1.8-2.5h; and the vacuum drying is vacuum drying at 90°C for 30-35min.

[0020] The invention discloses a preparation method of the above-mentioned anti-inflammatory composition containing basil extract, which comprises the following steps: adding an anti-allergic agent, a moisturizer, an emulsifier and a thickener into deionized water, stirring at a speed of 300-400 rpm for 10-15 minutes, then adding the anti-inflammatory complex, stirring at a temperature of 10-12° C. and a speed of 220-250 rpm for 10-15 minutes, and obtaining the composition.

[0021] Beneficial effects of the present invention:

[0022] 1. The present invention utilizes carboxymethyl chitosan to relieve skin inflammation and moisturize, maintain moisture balance, and relieve dryness and itching. It, together with the active ingredients of wheat germ, basil, and perilla extracts, inhibits inflammation, resists oxidation, removes free radicals, and protects cells from oxidative damage. At the same time, carboxymethyl chitosan can also promote wound healing and enhance anti-inflammatory effects.

[0023] 2. The present invention utilizes dipotassium glycyrrhizinate to regulate immunity and inhibit inflammatory mediators, while ectoine protects cells and stabilizes cell membranes to fight inflammation. Ectoine enhances the anti-inflammatory effect of dipotassium glycyrrhizinate, reduces cell damage and oxidative stress, maintains normal cell function, and reduces inflammation.

[0024] 3. The present invention forms a compound by using p-hydroxycinnamaldehyde, perilla extract, carboxymethyl chitosan and amino acids, thereby increasing stability and antibacterial properties. By combining multiple natural ingredients to form different antioxidant mechanisms and mutually synergistic antibacterial mechanisms, the antioxidant and antibacterial properties of the composition are significantly improved. DETAILED DESCRIPTION

[0025] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0026] Example 1

[0027] An anti-inflammatory composition containing basil extract comprises the following components by weight: 40 parts of anti-inflammatory compound, 1 part of moisturizer, 0.2 parts of emulsifier, 0.06 parts of anti-allergic agent, 0.03 parts of thickener and 110 parts of deionized water;

[0028] The moisturizer is a mixture of glycerol and D-panthenol in a mass ratio of 2:1; the emulsifier is glyceryl stearate; the anti-allergic agent is a mixture of dipotassium glycyrrhizinate and ectoine in a mass ratio of 1.5:1; the thickener is hydroxyethyl cellulose;

[0029] The method for preparing the anti-inflammatory compound comprises the following steps:

[0030] S1. Dry basil leaves and perilla leaves, grind them, and pass them through a 40-mesh sieve to obtain a mixed powder. Mix the mixed powder, rectorite and deionized water, add them to an extraction tank after ultrasonic treatment at 180 W for 15 minutes, and distill them at 58° C. for 5 hours using steam distillation. After the distillation, collect the essential oil, and dehydrate it with anhydrous sodium sulfate to obtain a composite extract; wherein the mass ratio of the basil leaves to the perilla leaves is 1:0.6; the mass ratio of the mixed powder, rectorite and deionized water is 2:0.6:15;

[0031] S2. Under a nitrogen environment, p-hydroxycinnamaldehyde, wheat germ extract and composite extract are placed in anhydrous ethanol, stirred at 40°C and 500 rpm for 30 min, carboxymethyl chitosan solution is added, stirred at 60°C for 4 h, centrifuged to remove the supernatant, and freeze-dried to obtain an anti-inflammatory complex; wherein the mass ratio of p-hydroxycinnamaldehyde, wheat germ extract, composite extract, anhydrous ethanol and carboxymethyl chitosan solution is 4.2:6.2:2.8:70:100; the carboxymethyl chitosan solution is prepared by mixing carboxymethyl chitosan and deionized water in a mass ratio of 1.0:22.

[0032] The preparation method of the wheat germ extract comprises the following steps: mixing wheat germ powder and n-hexane for extraction, centrifuging to obtain the supernatant, removing the solvent by rotary evaporation, and vacuum drying to obtain the wheat germ extract; in the preparation of the wheat germ extract, the dosage ratio of the wheat germ powder and n-hexane is 11g:52mL; the extraction condition is leaching at 40°C for 1.8h; and the vacuum drying is vacuum drying at 90°C for 30min.

[0033] A preparation method of an anti-inflammatory composition containing basil extract comprises the following steps: adding an anti-allergic agent, a moisturizer, an emulsifier and a thickener into deionized water, stirring at 300 rpm for 10 minutes, then adding an anti-inflammatory complex, stirring at 10°C and 220 rpm for 10 minutes, to obtain the composition.

[0034] Example 2

[0035] An anti-inflammatory composition containing basil extract comprises the following components by weight: 46 parts of anti-inflammatory compound, 1.5 parts of moisturizer, 0.25 parts of emulsifier, 0.07 parts of anti-allergic agent, 0.04 parts of thickener and 115 parts of deionized water;

[0036] The moisturizer is a mixture of glycerol and D-panthenol in a mass ratio of 2:1; the emulsifier is glyceryl stearate; the anti-allergic agent is a mixture of dipotassium glycyrrhizinate and ectoine in a mass ratio of 1.5:1; the thickener is hydroxyethyl cellulose;

[0037] The method for preparing the anti-inflammatory compound comprises the following steps:

[0038] S1. Dry basil leaves and perilla leaves, grind them, and pass them through a 50-mesh sieve to obtain a mixed powder. Mix the mixed powder, rectorite and deionized water, add them to an extraction tank after ultrasonic treatment at 200 W power for 18 minutes, and distill them at 64° C. for 6 hours using steam distillation. After the distillation, collect the essential oil, and dehydrate it with anhydrous sodium sulfate to obtain a composite extract; wherein the mass ratio of the basil leaves to the perilla leaves is 1:0.7; the mass ratio of the mixed powder, rectorite and deionized water is 2:0.7:16;

[0039] S2. Under a nitrogen environment, p-hydroxycinnamaldehyde, wheat germ extract and composite extract are placed in anhydrous ethanol and stirred at 45°C and 550 rpm for 35 min, carboxymethyl chitosan solution is added and stirred at 65°C for 4.5 h, the supernatant is removed by centrifugation, and the anti-inflammatory complex is obtained after freeze-drying; wherein the mass ratio of p-hydroxycinnamaldehyde, wheat germ extract, composite extract, anhydrous ethanol and carboxymethyl chitosan solution is 4.6:6.4:3:75:105; the carboxymethyl chitosan solution is prepared by mixing carboxymethyl chitosan and deionized water in a mass ratio of 1.1:24.

[0040] The preparation method of the wheat germ extract comprises the following steps: mixing wheat germ powder and n-hexane for leaching, centrifuging to obtain the supernatant, removing the solvent by rotary evaporation, and vacuum drying to obtain the wheat germ extract; in the preparation of the wheat germ extract, the dosage ratio of the wheat germ powder and n-hexane is 11.5g:56mL; the extraction condition is leaching at 42°C for 2.2h; and the vacuum drying is vacuum drying at 90°C for 32min.

[0041] A method for preparing an anti-inflammatory composition containing basil extract comprises the following steps: adding an anti-allergic agent, a moisturizer, an emulsifier and a thickener into deionized water, stirring at 350 rpm for 12 minutes, then adding an anti-inflammatory complex, stirring at 11° C. and 235 rpm for 12 minutes, to obtain the composition.

[0042] Example 3

[0043] An anti-inflammatory composition containing basil extract comprises the following components by weight: 52 parts of anti-inflammatory compound, 2 parts of moisturizer, 0.3 parts of emulsifier, 0.08 parts of anti-allergic agent, 0.05 parts of thickener and 120 parts of deionized water;

[0044] The moisturizer is a mixture of glycerol and D-panthenol in a mass ratio of 2:1; the emulsifier is glyceryl stearate; the anti-allergic agent is a mixture of dipotassium glycyrrhizinate and ectoine in a mass ratio of 1.5:1; the thickener is hydroxyethyl cellulose;

[0045] The method for preparing the anti-inflammatory compound comprises the following steps:

[0046] S1. Dry basil leaves and perilla leaves, grind them, and pass them through a 60-mesh sieve to obtain a mixed powder. Mix the mixed powder, rectorite and deionized water, add them to an extraction tank after ultrasonic treatment at 220 W power for 20 minutes, and distill them at 70° C. for 7 hours using steam distillation. After the distillation, collect the essential oil, and dehydrate it with anhydrous sodium sulfate to obtain a composite extract; wherein the mass ratio of the basil leaves to the perilla leaves is 1:0.8; the mass ratio of the mixed powder, rectorite and deionized water is 2:0.8:18;

[0047] S2. Under a nitrogen environment, p-hydroxycinnamaldehyde, wheat germ extract and composite extract are placed in anhydrous ethanol, stirred at 50°C and 600 rpm for 40 min, carboxymethyl chitosan solution is added, stirred at 70°C for 5 h, centrifuged to remove the supernatant, and freeze-dried to obtain an anti-inflammatory complex; wherein the mass ratio of p-hydroxycinnamaldehyde, wheat germ extract, composite extract, anhydrous ethanol and carboxymethyl chitosan solution is 5.0:6.6:3.3:80:110; the carboxymethyl chitosan solution is prepared by mixing carboxymethyl chitosan and deionized water in a mass ratio of 1.2:25.

[0048] The preparation method of the wheat germ extract comprises the following steps: mixing wheat germ powder and n-hexane for extraction, centrifuging to obtain the supernatant, removing the solvent by rotary evaporation, and vacuum drying to obtain the wheat germ extract; in the preparation of the wheat germ extract, the dosage ratio of the wheat germ powder and n-hexane is 12g:60mL; the extraction condition is leaching at 45°C for 2.5h; and the vacuum drying is vacuum drying at 90°C for 35min.

[0049] A method for preparing an anti-inflammatory composition containing basil extract comprises the following steps: adding an anti-allergic agent, a moisturizer, an emulsifier and a thickener into deionized water, stirring at 400 rpm for 15 minutes, then adding an anti-inflammatory complex, stirring at 12° C. and 250 rpm for 15 minutes, to obtain the composition.

[0050] Comparative Example 1

[0051] Compared with Example 3, the difference in Comparative Example 1 is that basil leaves replace perilla leaves, and the other components, preparation steps and parameters are the same.

[0052] Comparative Example 2

[0053] Compared with Example 3, the difference in Comparative Example 2 is that Perilla leaves replace basil leaves, and the other components, preparation steps and parameters are the same.

[0054] Comparative Example 3

[0055] Compared with Example 3, the difference in Comparative Example 3 is that wheat germ extract replaces the composite extract, and the other components, preparation steps and parameters are the same.

[0056] Comparative Example 4

[0057] Compared with Example 3, the difference in Comparative Example 4 is that the composite extract replaces the wheat germ extract, and the other components, preparation steps and parameters are the same.

[0058] Comparative Example 5

[0059] Compared with Example 3, Comparative Example 5 is different in that no rectorite is used, and the other components, preparation steps and parameters are the same.

[0060] Comparative Example 6

[0061] Compared with Example 3, Comparative Example 6 is different in that p-hydroxycinnamaldehyde is not used, and the remaining components, preparation steps and parameters are the same.

[0062] Comparative Example 7

[0063] Compared with Example 3, Comparative Example 7 is different in that carboxymethyl chitosan is not used, and the other components, preparation steps and parameters are the same.

[0064] The compositions prepared in Examples 1-3 and Comparative Examples 1-7 were subjected to the following performance tests respectively.

[0065] Antibacterial performance test:

[0066] Activated Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922 and Candida albicans ATCC14053 were inoculated onto ordinary broth medium agar plates and cultured at 37°C for 24 hours. Subsequently, the bacteria were appropriately diluted with nutrient broth, and the sample composition (Example 1-3, Comparative Example 1-7) was added and incubated for 90 minutes. Take out 50 μL of sample for plate coating, and then invert and culture at 37°C for 24 hours to observe the growth of the colony. Using sterile water as a blank control, the antibacterial rate of each embodiment and comparative example was calculated, and the results are shown in Table 1.

[0067] DPPH free radical scavenging test:

[0068] DPPH was prepared with anhydrous ethanol to 2×10 -4mol / L solution, sample composition (Example 1-3, Comparative Example 1-7) as the sample to be tested, prepare several portions of 2mL each of the test liquid, anhydrous ethanol, and DPPH solution, respectively, and place them at room temperature for 30 minutes after mixing, and measure the absorbance at a wavelength of 517nm to obtain Ai, and measure each sample in parallel 3 times to take the average value. Vc is used as a positive control, and anhydrous ethanol is used to replace DPPH to measure the absorbance value as a control Aj blank, and the absorbance Ac is measured by mixing DPPH solution and anhydrous ethanol. The scavenging rate of each sample to be tested for DPPH free radicals is calculated according to the following formula, and the results are shown in Table 1;

[0069] DPPH free radical scavenging rate (%) = (1-(Ai-Aj) / Ac) × 100%;

[0070] Table 1 Test results

[0071]

[0072] From the test results in Table 1, it can be seen that compared with Comparative Examples 1-7, the compositions prepared in Examples 1-3 of the present invention have excellent antibacterial properties and DPPH free radical elimination properties.

[0073] Anti-inflammatory experimental test: 120 ordinary mice were used in the experiment, with a weight range of 20 ± 2 grams and a gender ratio of half male and half female. After a week of conventional feeding, these mice were randomly assigned to 12 different groups, each containing 10 mice. These groups include hydrocortisone cream as a positive control group, saline as a negative control group, and Example 1-3 group and Comparative Example 1-7 group. In these experimental groups, the compounds used were dissolved in sterile water and prepared into a solution with a concentration of 30 mg / ml as a test solution. During the experiment, 0.05 mL of xylene was evenly applied to both sides of the right ear of each mouse. After waiting for 30 minutes, 0.05 mL of the corresponding liquid was evenly applied to both sides of the right ear. The left ear was used as a self-control. After 120 minutes of administration, the mice were killed by cervical dislocation, and then the ears were cut off along the auricle baseline. The ear pieces were removed from the same part of the left and right ears using a 7 mm diameter puncher and were immediately weighed accurately. When calculating the swelling degree, the weight of the right ear piece was subtracted from the weight of the left ear piece, and the ear swelling rate was calculated by (right ear weight - left ear weight) / left ear weight × 100%. The experimental results are shown in Table 2.

[0074] Table 2

[0075] Ear swelling rate (%) Example 1 9.6 Example 2 9.3 Example 3 9.2 Comparative Example 1 13.9 Comparative Example 2 12.2 Comparative Example 3 14.4 Comparative Example 4 11.8 Comparative Example 5 12.6 Comparative Example 6 14.2 Comparative Example 7 13.3 Negative control group 19.6 Positive control group 8.6

[0076] From the test results in Table 2, it can be seen that compared with Comparative Examples 1-7, the compositions prepared in Examples 1-3 have excellent anti-inflammatory effects.

[0077] Through comparative analysis, it can be seen that this is because the phytosterols in wheat germ extract and perillaldehyde in perilla extract can both destroy the bacterial cell membrane, while the eugenol and myrcene in basil extract further enhance this effect, making the cell membrane more unstable and accelerating the leakage of intracellular components; limonene in perilla extract and eugenol in basil extract respectively interfere with the bacterial energy metabolism and respiratory chain, and jointly inhibit the bacterial energy supply, making it impossible for the bacteria to survive normally; carboxymethyl chitosan interacts with the bacterial cell membrane through its positive charge, thereby enhancing the entry efficiency of other antibacterial ingredients wheat germ extract, basil extract, perilla extract and p-hydroxycinnamaldehyde, and improving the overall antibacterial and anti-inflammatory effects.

[0078] Through comparative analysis, it can be known that this is because the vitamin E in the wheat germ extract, the perillaldehyde in the perilla extract and the eugenol in the basil extract utilized in the present invention are all effective free radical scavengers, and their combined action can more effectively interrupt the oxidation chain reaction and reduce cell damage; the phytosterols and carboxymethyl chitosan in the wheat germ extract can synergistically promote the activity of antioxidant enzymes and enhance the overall antioxidant defense ability of cells; the limonene in the perilla extract and the myrcene in the basil extract scavenge free radicals through different pathways, and their combined action can cover more oxidation reaction types and improve the overall antioxidant effect.

[0079] In addition, the present invention utilizes wheat germ extract containing multiple amino acids and amino groups on carboxymethyl chitosan to form Schiff base compounds with stronger antioxidant and antibacterial abilities with aldehyde groups of perilla extract rich in perilla aldehyde and polyhydroxycinnamaldehyde, and can also promote their own stability to significantly improve the antibacterial and antioxidant properties. The Schiff base compound can also serve as a porous carrier of basil extract to protect its structure from being destroyed, and significantly improve its antioxidant ability and antibacterial properties through a long-lasting sustained release effect.

[0080] Furthermore, carboxymethyl chitosan can not only significantly relieve skin inflammation, but also has moisturizing properties, which helps maintain the moisture balance of the skin, thereby reducing itching caused by dry skin. It is combined with the active ingredients in wheat germ extract, basil extract and perilla extract to inhibit the release of inflammatory factors, and they all have significant antioxidant effects, which can scavenge free radicals and reduce oxidative stress, thereby synergistically protecting cells from oxidative damage and reducing inflammatory reactions. Carboxymethyl chitosan synergistically exerts anti-inflammatory effects by promoting wound healing.

[0081] Dipotassium glycyrrhizinate mainly exerts its effects by regulating immune responses and inhibiting inflammatory mediators, while ectoine exerts its anti-inflammatory effects through physical protection and cell membrane stabilization. The cytoprotective effect of ectoine can enhance the anti-inflammatory effect of dipotassium glycyrrhizinate, and by reducing cell damage and oxidative stress, they jointly maintain the normal function of cells and reduce the occurrence of inflammation.

[0082] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any indirect modification, equivalent change and modification made to the above embodiments according to the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. An anti-inflammatory composition containing basil extract, characterized in that: The components include the following by weight: 40-52 parts of anti-inflammatory compound, 1-2 parts of moisturizer, 0.2-0.3 parts of emulsifier, 0.06-0.08 parts of anti-allergic agent, 0.03-0.05 parts of thickener and 110-120 parts of deionized water; The method for preparing the anti-inflammatory compound comprises the following steps: S1, drying basil leaves and perilla leaves, grinding and sieving to obtain a mixed powder, mixing the mixed powder, rectorite and deionized water, adding the mixed powder to an extraction tank after ultrasonic treatment, extracting by steam distillation, collecting essential oil after distillation, and dehydrating with anhydrous sodium sulfate to obtain a composite extract; S2. Under a nitrogen environment, p-hydroxycinnamaldehyde, wheat germ extract and composite extract are placed in anhydrous ethanol and stirred to mix, carboxymethyl chitosan solution is added and stirred at a constant temperature, the supernatant is removed by centrifugation, and the mixture is freeze-dried to obtain the product.

2. The anti-inflammatory composition containing basil extract according to claim 1, characterized in that: The moisturizing agent is one or more of glycerin, hydroxyethyl urea, D-panthenol, propylene glycol, butylene glycol, betaine, hyaluronic acid and sodium hyaluronate.

3. The anti-inflammatory composition containing basil extract according to claim 1, characterized in that: The emulsifier is one or more of glycerol stearate, sucrose stearate and sucrose palmitate.

4. The anti-inflammatory composition containing basil extract according to claim 1, characterized in that: The anti-allergic agent is one or more of dipotassium glycyrrhizinate and ectoine.

5. The anti-inflammatory composition containing basil extract according to claim 1, characterized in that: The thickener is one or more of hydroxyethyl cellulose, xanthan gum and carbomer.

6. The anti-inflammatory composition containing basil extract according to claim 1, characterized in that: In step S1, the screening is through a 40-60 mesh sieve; the ultrasonic treatment is ultrasonic treatment at a power of 180-220 W for 15-20 min; the extraction parameter is distillation at a temperature of 58-70° C. for 5-7 h; the mass ratio of the basil leaves to the perilla leaves is 1:0.6-0.8; the mass ratio of the mixed powder, rectorite and deionized water is 2:0.6-0.8:15-18.

7. The anti-inflammatory composition containing basil extract according to claim 1, characterized in that: In step S2, the stirring and mixing is stirring at a temperature of 40-50°C and a speed of 500-600rpm for 30-40min; the constant temperature stirring is stirring at a temperature of 60-70°C for 4-5h; the mass ratio of the p-hydroxycinnamaldehyde, wheat germ extract, composite extract, anhydrous ethanol and carboxymethyl chitosan solution is 4.2-5.0:6.2-6.6:2.8-3.3:70-80:100-110; the carboxymethyl chitosan solution is formed by mixing carboxymethyl chitosan and deionized water in a mass ratio of 1.0-1.2:22-25.

8. The anti-inflammatory composition containing basil extract according to claim 1, characterized in that: The preparation method of the wheat germ extract comprises the following steps: mixing wheat germ powder and normal hexane for leaching, centrifuging to obtain supernatant, rotary evaporating to remove the solvent, and vacuum drying to obtain the extract.

9. The anti-inflammatory composition containing basil extract according to claim 8, characterized in that: In the preparation of the wheat germ extract, the usage ratio of the wheat germ powder and n-hexane is 11-12 g: 52-60 mL; the extraction condition is leaching at 40-45° C. for 1.8-2.5 h; and the vacuum drying is vacuum drying at 90° C. for 30-35 min.

10. A method for preparing the anti-inflammatory composition containing basil extract according to any one of claims 1 to 9, characterized in that: The preparation method comprises the following steps: adding an anti-allergic agent, a moisturizing agent, an emulsifier and a thickener into deionized water, stirring at 300-400 rpm for 10-15 minutes, then adding the anti-inflammatory complex, stirring at 10-12° C. and 220-250 rpm for 10-15 minutes, and obtaining the product.

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