Transcranial electrical stimulation system and method with variable current direction

Abstract

The invention discloses a transcranial electrical stimulation system and method with a variable current direction, the system comprises an acquisition unit, a control unit and a stimulation unit, the acquisition unit is used for acquiring first EEG data of a target object in a first time period; the control unit is used for determining a first stimulation scheme according to a preset stimulation target; the stimulation unit is used for stimulating the target object through the transcranial electrical stimulation equipment according to the first stimulation scheme to obtain second EEG data; the control unit is further used for determining whether a preset stimulation target is achieved or not according to the first EEG data and the second EEG data; when the preset stimulation target is not reached, determining a second stimulation current direction according to the first EEG data, the second EEG data and the preset stimulation target; and adjusting the first stimulation current direction to a second stimulation current direction. By adopting the embodiment of the invention, the direction of the stimulation current can be simply and quickly adjusted on the premise that the position of the electrode is fixed.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to a transcranial electrical stimulation system and method with variable current direction. Background Art

[0002] Transcranial electrical stimulation technology is increasingly being used in the fields of neuroscience research, mental illness treatment, cognitive enhancement, and rehabilitation medicine. During transcranial electrical stimulation, after the electrodes of the transcranial electrical stimulation are fixed, the direction of the stimulation current becomes one of the key factors affecting the stimulation effect.

[0003] At present, in transcranial electrical stimulation, the direction of the stimulation current is generally adjusted indirectly by adjusting the position distribution of the electrodes. However, this adjustment method has obvious disadvantages. The operation process is extremely complicated, which not only consumes a lot of time and energy, but also may affect the final stimulation effect due to inaccurate operation. Therefore, under the premise of fixing the position of the electrodes, how to simply and quickly adjust the direction of the stimulation current has become an urgent problem to be solved. Summary of the invention

[0004] The embodiments of the present application provide a transcranial electrical stimulation system and method with variable current direction, which can simply and quickly adjust the direction of the stimulation current under the premise of fixing the electrode position.

[0005] In a first aspect, an embodiment of the present application provides a transcranial electrical stimulation system with variable current direction, the system is connected to a transcranial electrical stimulation device, the transcranial electrical stimulation device includes three electrodes, the system includes: an acquisition unit, a control unit, and a stimulation unit, wherein: The acquisition unit is used to acquire first EEG data of the target object within a first time period; The control unit is used to determine a first stimulation scheme corresponding to the target object according to a preset stimulation target; the first stimulation scheme includes: three positions corresponding to the three electrodes on the brain of the target object, a first stimulation current direction, and a first stimulation current intensity; the first stimulation current direction and the first stimulation current intensity are obtained by vector calculation of the currents of the three electrodes; each electrode corresponds to one position; The stimulation unit is used to stimulate the target object according to the first stimulation scheme through the transcranial electrical stimulation device to obtain second EEG data; The control unit is also used to determine whether the preset stimulation target is achieved based on the first EEG data and the second EEG data; when the preset stimulation target is not achieved, determine the second stimulation current direction based on the first EEG data, the second EEG data and the preset stimulation target; and adjust the first stimulation current direction to the second stimulation current direction.

[0006] In a second aspect, an embodiment of the present application provides a transcranial electrical stimulation method with variable current direction, which is applied to a transcranial electrical stimulation device, wherein the transcranial electrical stimulation device includes three electrodes, and the method includes: Acquire first EEG data of the target object within a first time period; Determine a first stimulation scheme corresponding to the target object according to a preset stimulation target; the first stimulation scheme includes: three positions corresponding to the three electrodes on the target object's brain, a first stimulation current direction, and a first stimulation current intensity; the first stimulation current direction and the first stimulation current intensity are obtained by vector calculation of the currents of the three electrodes; each electrode corresponds to one position; Stimulating the target object according to the first stimulation scheme by the transcranial electrical stimulation device to obtain second EEG data; Determine whether the preset stimulation target is achieved based on the first EEG data and the second EEG data; when the preset stimulation target is not achieved, determine the second stimulation current direction based on the first EEG data, the second EEG data and the preset stimulation target; adjust the first stimulation current direction to the second stimulation current direction.

[0007] In a third aspect, an embodiment of the present application provides an electronic device, comprising: a processor, a memory, a communication interface, and one or more programs, wherein the one or more programs are stored in the memory and configured to be executed by the processor, and the program includes instructions for executing the steps in the second aspect of the embodiment of the present application.

[0008] In a fourth aspect, an embodiment of the present application provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program for electronic data exchange, wherein the computer program enables a computer to execute part or all of the steps described in the second aspect of the embodiment of the present application.

[0009] In a fifth aspect, an embodiment of the present application provides a computer program product, wherein the computer program product includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause a computer to execute some or all of the steps described in the second aspect of the embodiment of the present application. The computer program product may be a software installation package.

[0010] The implementation of this application has the following beneficial effects: It can be seen that the transcranial electrical stimulation system with variable current direction described in the present application can intuitively understand the impact of transcranial electrical stimulation on brain electrical activity by acquiring the changes in EEG data of the target object in real time during the stimulation process and by comparing the first EEG data and the second EEG data. If the preset stimulation target is not achieved, it means that the current stimulation scheme, especially the stimulation current direction, is not optimal. At this time, it is necessary to adjust the output parameters of the transcranial electrical stimulation device through the control unit to adjust the first stimulation current direction to the second stimulation current direction. Since there is no need to adjust the position of the electrode, complex mechanical operations and repositioning processes are avoided, the adjustment time is greatly shortened, and the direction of the stimulation current can be adjusted simply and quickly under the premise of fixing the electrode position. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the background technology, the drawings required for use in the embodiments of the present application or the background technology will be described below.

[0012] Figure 1 This is an application scenario diagram of a transcranial electrical stimulation system with variable current direction provided in an embodiment of the present application; Figure 2 is a schematic diagram of the structure of a transcranial electrical stimulation device provided in an embodiment of the present application; Figure 3 It is a schematic structural diagram of a transcranial electrical stimulation system with variable current direction provided in an embodiment of the present application; Figure 4 is a flow chart of a method for determining an electrode position provided in an embodiment of the present application; Figure 5 is a structural schematic diagram of a target resistance model provided in an embodiment of the present application; Figure 6 is a structural schematic diagram of a vector current synthesis model provided in an embodiment of the present application; Figure 7 It is a flow chart of a transcranial electrical stimulation method with variable current direction provided in an embodiment of the present application; Figure 8 It is a structural schematic diagram of an electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0013] In order to enable those skilled in the art to better understand the solution of the present application, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0014] The terms "first", "second", etc. in the specification and claims of this application and the above-mentioned drawings are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but optionally includes steps or units that are not listed, or optionally includes other steps or units inherent to these processes, methods, products or devices.

[0015] It should be understood that the term "and / or" in this article is only a description of the association relationship of associated objects, indicating that there can be three relationships. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " in this article indicates that the associated objects before and after are in an "or" relationship. The "plurality" appearing in the embodiments of the present application refers to two or more.

[0016] In the embodiments of the present application, "at least one item" or similar expressions refer to any combination of these items, including any combination of single items or plural items, and refer to one or more, and multiple refers to two or more. For example, at least one item of a, b, or c can represent the following seven situations: a, b, c, a and b, a and c, b and c, a, b, and c. Among them, each of a, b, and c can be an element or a set containing one or more elements.

[0017] The "connection" that appears in the embodiments of the present application refers to various connection methods such as direct connection or indirect connection to achieve communication between devices, and the embodiments of the present application do not impose any limitations on this.

[0018] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0019] The electronic device described in the embodiments of the present application may include a transcranial electrical stimulation device.

[0020] The following is an explanation of the relevant contents, concepts, meanings, technical issues, technical solutions, beneficial effects, etc. involved in the embodiments of the present application.

[0021] First, some professional terms involved in this application are explained: Transcranial Electrical Stimulation (tES): is a non-invasive neuromodulation technology that applies a weak electric current (usually direct current or alternating current) to the brain through electrodes placed on the surface of the scalp. The electric current can penetrate tissues such as the scalp and skull, act on neurons in the cerebral cortex, affect the excitability of neurons, and then regulate the brain's electrical activity and neural function. Common types include transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), etc., which are used to explore the functional mechanisms of the brain in neuroscience research, and can assist in the treatment of various diseases such as depression, chronic pain, neurorehabilitation, etc. in clinical treatment. It can also be used in fields such as cognitive enhancement.

[0022] EEG data (Electroencephalogram data): EEG data is obtained by recording the potential changes caused by the electrical activity of neurons in the cerebral cortex through electrodes placed on the scalp. The electrical activity of brain neurons will produce weak bioelectric signals, which are transmitted to the surface of the scalp through tissues such as the scalp and skull. These signals can be collected, amplified and recorded by EEG equipment. EEG data contains rich information about brain functions. Different EEG frequency bands reflect different functional states of the brain, such as sleep, wakefulness, and concentration. It is widely used in neuroscience research, clinical diagnosis (such as epilepsy diagnosis), brain-computer interfaces and other fields.

[0023] Three-phase star circuit: It is a connection method for three-phase AC circuits. In a three-phase AC system, there are three AC power sources (voltage or current) with the same frequency, equal amplitude, and a phase difference of 120°. The three ends of the three-phase power supply are connected together to form a neutral point, and the three ends are respectively led out as output ends to form a three-phase star connection circuit. This circuit connection method is widely used in power systems, such as power transmission, motor power supply and other scenarios. In some transcranial electrical stimulation applications involving three-phase current, the head and the electrode can be equivalent to a three-phase star circuit, which is used to analyze and control the vector synthesis of current and other situations.

[0024] Vector composite current: In a three-phase AC circuit or a system involving multi-phase current, since each phase current has a different amplitude and phase, according to the principle of vector superposition, the total current obtained by synthesizing these current vectors is the vector composite current. Taking a three-phase star circuit as an example, three AC currents with a phase difference of 120° can be superimposed by vectors to obtain a total current vector with a specific direction and amplitude. In this application, by controlling the amplitude and phase of each electrode current in the three-phase star circuit, vector composite currents of different directions and amplitudes can be synthesized to achieve precise stimulation and regulation of specific areas and functions of the brain.

[0025] Clarke transformation: also known as α-β transformation, is a mathematical transformation that converts physical quantities in a three-phase stationary coordinate system (abc coordinate system) into a two-phase stationary coordinate system (α-β coordinate system).

[0026] Park transformation: It is a mathematical transformation that converts physical quantities in a two-phase stationary coordinate system (α-β coordinate system) into a rotating coordinate system (dq coordinate system).

[0027] Inverse Park transform: It is the inverse operation of Park transform, which converts the physical quantity in the rotating coordinate system (dq coordinate system) back to the two-phase stationary coordinate system (α-β coordinate system).

[0028] Brain map: a tool for visualizing and standardizing the presentation of brain structure and function information. It integrates data obtained from neuroimaging techniques (such as magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), etc.) and combines it with neuroanatomy knowledge to depict the location, morphology, structure, and functional information of different brain regions. Common brain maps include the MNI brain map and the Talairach brain map. Brain maps are used in neuroscience research to locate specific functional areas of the brain, assist in neurosurgery planning, and help determine electrode placement and stimulation targets in neuromodulation techniques such as transcranial electrical stimulation.

[0029] 10-20 electrode system: It is a standard system for EEG electrode placement specified by the International Electroencephalography Society. This system is based on skull landmarks and determines the placement of electrodes according to a certain proportional relationship. It can accurately locate different areas of the brain on the scalp surface. "10" and "20" indicate that the distance between electrodes is determined by 10% or 20% of the skull circumference or sagittal line length. The system includes multiple electrode positions; in EEG recording, transcranial electrical stimulation and other operations, the 10-20 electrode system is widely used to ensure the standardization of electrode placement and comparability between different studies or clinical operations.

[0030] Peak-to-peak value: refers to the difference between the maximum and minimum values ​​in a periodic signal. For periodic signals, such as sine waves and square waves, the signal will fluctuate between the maximum and minimum values ​​in a complete cycle, and the peak-to-peak value is a parameter that describes this fluctuation range. For example, the maximum voltage of a sine wave is +5V and the minimum is -5V, so its peak-to-peak value is 5V-(-5V)=10V.

[0031] See also Figure 1 , Figure 1This is an application scenario diagram of a transcranial electrical stimulation system with variable current direction provided in an embodiment of the present application. It can be seen that the transcranial electrical stimulation system with variable current direction (hereinafter referred to as the system) communicates and / or is physically connected with a transcranial electrical stimulation device; the transcranial electrical stimulation device includes three electrodes, namely a first electrode, a second electrode and a third electrode, wherein: The above system is the control core of the entire transcranial electrical stimulation process, responsible for coordinating the work of various parts and realizing the function of variable current direction. The system can determine the appropriate stimulation plan based on the preset stimulation target, collected EEG data and other information, including adjusting parameters such as current direction and intensity.

[0032] The transcranial electrical stimulation device can receive instructions from the system, generate corresponding electrical stimulation signals according to the set stimulation scheme, and output them to the target subject's brain through three electrodes. It is an execution device that converts system instructions into actual electrical stimulation.

[0033] The target object is the target object that receives transcranial electrical stimulation. The target object's head is equipped with three electrodes of the transcranial electrical stimulation device, namely the first electrode, the second electrode and the third electrode. These electrodes are the interface for the electrical stimulation signal to enter the brain. By adjusting the parameters of the output current of the three electrodes (such as amplitude and phase), stimulation currents of different directions and intensities can be synthesized to achieve stimulation regulation of specific areas of the brain to achieve treatment or research purposes.

[0034] See also Figure 2 , Figure 2 : is a schematic diagram of the structure of a transcranial electrical stimulation device provided in an embodiment of the present application; it can be seen that the transcranial electrical stimulation device may include: a power module, a control module, a data acquisition module, and an electrode module, wherein the electrode module may include 3 or more electrodes; wherein: The power module is used to provide stable power for the transcranial electrical stimulation device. When the transcranial electrical stimulation device is working, different modules may have different requirements for power. The power module is responsible for converting the external power supply (such as AC power or battery) into a suitable voltage and current form. For example, it converts 220V AC power into different voltage levels such as 5V and 12V to power the control module, data acquisition module, etc. The power module can also have a power management function, which can monitor the power status and perform overcurrent, overvoltage, and undervoltage protection. When the power supply is abnormal, the power supply is cut off or the output is adjusted in time to avoid damage to the equipment due to power problems and ensure the safety of the equipment and users.

[0035] The control module is used to receive instructions from the outside (such as a transcranial electrical stimulation system with variable current direction), parse and process these instructions. For example, according to the preset stimulation scheme, the parameters of the electrode output current (such as amplitude, frequency, waveform, etc.) are determined. It can also coordinate the work of various modules inside the device, for example, control the output state of the power module, start the data acquisition module for data acquisition and transmission, and adjust the current output size of the electrode module, so that the entire device can operate in an orderly manner and achieve the expected transcranial electrical stimulation function.

[0036] The data acquisition module is used to collect various signals related to transcranial electrical stimulation, mainly including electrophysiological signals of the brain (such as EEG signals) and current and voltage signals output by electrodes. Through high-precision sensors and amplifiers, weak bioelectric signals and electrical stimulation signals are collected and amplified; the data acquisition module can also transmit the collected data to the control module or external devices (such as connecting to a computer for storage and analysis). The transmitted data can provide a basis for the control module to adjust the stimulation parameters, and can also be used for subsequent data analysis and research to evaluate the effect of transcranial electrical stimulation.

[0037] The electrode module is used to output the electrical stimulation signal to the brain of the target object according to the instructions of the control module. By contacting the scalp, the current can enter the brain tissue and stimulate the brain neurons. Factors such as the material, shape and contact area of ​​the electrode with the scalp will affect the distribution of the current and the stimulation effect. The electrode module can also monitor the electrode status, such as contact resistance and other parameters. If problems such as poor electrode contact are found, feedback will be given to the control module in a timely manner so that corresponding measures can be taken (such as adjusting the electrode position or issuing prompt information) to ensure the stability and effectiveness of the electrical stimulation.

[0038] See also Figure 3 , Figure 3 : is a schematic diagram of the structure of a transcranial electrical stimulation system with variable current direction provided in an embodiment of the present application; it can be seen that the system can be physically and / or communicatively connected to a transcranial electrical stimulation device, the transcranial electrical stimulation device includes 3 electrodes, and the system includes: an acquisition unit, a control unit, and a stimulation unit, wherein: The acquisition unit is used to acquire first EEG data of the target object within a first time period.

[0039] In the embodiment of the present application, the EEG data may include at least one of the following: frequency component data, time domain feature data, spatial distribution data, etc., which are not limited here.

[0040] In a specific embodiment, the acquisition unit may be an EEG acquisition device. According to the standard of the 10-20 electrode system, the acquisition electrodes of the EEG acquisition device are set on the scalp of the target object. Then, the EEG acquisition device may be calibrated and debugged. For example, parameters such as amplifier gain and filter settings may be checked to ensure that the device works properly and the signal is acquired accurately, and a suitable sampling rate (such as 256 Hz, 512 Hz) and resolution may be set to meet different research or clinical needs. Then, when the starting time of the first time period is reached, the EEG acquisition device is started to collect the EEG data of the target object to obtain the first EEG data.

[0041] It should be explained that the first time period can be preset or defaulted in advance. For example, the first time period can be set according to the research purpose or clinical needs. For example, when studying EEG activity during sleep, the first time period can be set to a specific length of time after the target subject falls asleep. If observing EEG changes during cognitive tasks, the start time is set before the task begins, and the end time is determined after the task is completed.

[0042] A control unit is used to determine a first stimulation scheme corresponding to the target object according to a preset stimulation target; the first stimulation scheme includes: three positions corresponding to three electrodes on the target object's brain, a first stimulation current direction, and a first stimulation current intensity; the first stimulation current direction and the first stimulation current intensity are obtained by vector calculation of the currents of the three electrodes; each electrode corresponds to one position.

[0043] In the embodiment of the present application, the preset stimulation target can be preset in advance or defaulted.

[0044] In a specific embodiment, the control unit can receive and analyze the preset stimulation target, and convert the preset stimulation target into an operational parameter indicator. For example, if the preset stimulation target is to increase the excitability of a specific area of ​​the brain, the control unit will convert it into a corresponding quantitative parameter range such as current intensity, current direction, frequency, etc., thereby obtaining the first stimulation plan corresponding to the target object.

[0045] Optionally, in determining the first stimulation scheme corresponding to the target object according to a preset stimulation target, the control unit is specifically configured to: A1. Determine a reference stimulation scheme corresponding to the preset stimulation target; the reference stimulation scheme includes: a reference stimulation current direction and a reference stimulation current intensity; A2. determining the three positions of the three electrodes on the brain of the target subject according to the reference stimulation current direction; A3. Acquiring target physiological data of the target object; A4. Determine the difference between the target physiological data and the preset physiological data to obtain a target difference; A5. Determine a first adjustment factor corresponding to the target difference; A6. adjusting the reference stimulation current intensity according to the first adjustment factor to obtain a second stimulation current intensity; A7. Acquire historical transcranial electrical stimulation data of the target object; A8. determining a target tolerance based on the historical transcranial electrical stimulation data; A9. Determine a second adjustment factor corresponding to the target tolerance; A10, adjusting the second stimulation current intensity according to the second adjustment factor to obtain a third stimulation current intensity; A11. Determine the first stimulation scheme according to the third stimulation current intensity and the reference stimulation current direction.

[0046] In the embodiment of the present application, the target physiological data may include at least one of the following: age, weight, blood oxygen concentration, blood pressure, blood sugar, etc., which are not limited here; the preset physiological data can be preset or defaulted in advance.

[0047] In a specific embodiment, a reference stimulation scheme corresponding to a preset stimulation target can be determined. Specifically, relevant medical literature, hospital databases, medical websites, etc. can be consulted to obtain research data on the preset stimulation target, and the reference stimulation scheme can be determined based on the research data. For example, assuming that the preset stimulation target is to increase the excitability of the cerebral cortex of the target object by 10%, a study in a certain medical literature pointed out that transcranial direct current stimulation (tDCS) with a frequency of 20~50Hz and current flowing from front to back (AP) has been shown to promote the excitability of the cerebral cortex, and the effect is better when the stimulation intensity is 1~2mA. The reference stimulation scheme can be designed as follows: the reference stimulation current direction is AP, and the reference stimulation current intensity can be 1.5mA.

[0048] Next, the three positions of the three electrodes on the target object's brain can be determined according to the reference stimulation current direction; then, the target physiological data of the target object can be obtained. Specifically, the target object can be tested by a special physiological examination device to obtain the target physiological data. For example, assuming that the target physiological data is the blood oxygen concentration, the physiological examination device can be a blood oxygen sensor, and the blood oxygen concentration of the target object is detected by the blood oxygen sensor, thereby obtaining the target physiological data; then, the difference between the target physiological data and the preset physiological data can be determined to obtain the target difference. The specific calculation formula is as follows: Target difference = (target physiological data - preset physiological data) / preset physiological data; According to the above formula, the target difference can be obtained; then, the first adjustment factor corresponding to the target difference can be determined. Specifically, a mapping relationship between a preset difference and an adjustment factor can be pre-stored, and the first adjustment factor corresponding to the target difference can be determined based on the mapping relationship; then, the reference stimulation current intensity can be adjusted according to the first adjustment factor. The specific calculation formula is as follows: The second stimulation current intensity = the first stimulation current intensity × (1 + the first adjustment factor); According to the above formula, the second stimulation current intensity can be obtained; then, the historical transcranial electrical stimulation data of the target object can be obtained. Specifically, the hospital where the target object has visited can be determined first, the target hospital can be obtained, the authorization information of the target hospital can be obtained, and the historical medical data of the target object can be queried from the database of the target hospital. All data related to transcranial electrical stimulation can be extracted from the historical medical data to obtain the historical transcranial electrical stimulation data.

[0049] Next, the target tolerance can be determined based on the historical transcranial electrical stimulation data; further, the second adjustment factor corresponding to the target tolerance can be determined. Similarly, the mapping relationship between the preset tolerance and the adjustment factor can be pre-stored, and the second adjustment factor corresponding to the target tolerance can be determined based on the mapping relationship; it should be explained that the value range of the first adjustment factor and the second adjustment factor can both be -0.3~0.3; further, the second stimulation current intensity can be adjusted according to the second adjustment factor, and the specific calculation formula is as follows: The third stimulation current intensity = the second stimulation current intensity × (1 + the second adjustment factor); According to the above formula, the third stimulation current intensity can be obtained; finally, the first stimulation scheme can be determined according to the third stimulation current intensity and the reference stimulation current direction. Specifically, the reference stimulation current direction can be used as the first stimulation current direction, and the third stimulation current intensity can be used as the first stimulation current intensity, that is, the first stimulation scheme.

[0050] In this way, by determining the reference stimulation scheme corresponding to the preset stimulation target, the direction and intensity of the reference stimulation current can be clarified, providing a basic standard scheme for subsequent stimulation therapy, so that the treatment has a reference basis and ensures that the treatment is carried out within a certain specification and range. In addition, the individual differences of the target objects are also taken into account. By adjusting the reference stimulation current intensity according to the target physiological data and target tolerance, a personalized stimulation scheme can be formulated for the target object, so that the first stimulation scheme can better adapt to the physical condition and stimulation needs of the target object.

[0051] Optionally, the historical transcranial electrical stimulation data includes m pieces of transcranial electrical stimulation data, where m is an integer greater than 1. In determining the target tolerance according to the historical transcranial electrical stimulation data, the control unit is specifically configured to: B1. determining the initial tolerance corresponding to the target physiological data; B2. Determine the stimulation current intensity and stimulation duration corresponding to each of the m pieces of transcranial electrical stimulation data, and obtain m stimulation current intensities and m stimulation durations; each stimulation current intensity corresponds to one stimulation duration; B3, multiplying the m stimulation current intensities by corresponding stimulation durations among the m stimulation durations to obtain m electrical stimulation amounts; B4, determining the starting stimulation time corresponding to each stimulation duration in the m stimulation durations, to obtain m starting stimulation times; B5. Performing curve fitting according to the m starting stimulation moments and the m electrical stimulation amounts to obtain a target curve; the abscissa of the target curve is the starting stimulation moment, and the ordinate is the electrical stimulation amount; B6. determining the first-order derivatives corresponding to the m starting stimulation moments in the target curve to obtain m first-order derivatives; B7. Determine the average first-order derivative corresponding to the m first-order derivatives; B8. Determine the target optimization factor corresponding to the average first-order derivative; B9. Optimizing the initial tolerance according to the target optimization factor to obtain the target tolerance.

[0052] In the embodiments of the present application, tolerance refers to the target object's tolerance and adaptability to transcranial electrical stimulation. Specifically, the tolerance value range may be 0 to 10, and the higher the tolerance value, the stronger the tolerance.

[0053] In a specific embodiment, the initial tolerance corresponding to the target physiological data can be determined first. Specifically, the mapping relationship between preset physiological data and tolerance can be pre-stored, and the initial tolerance corresponding to the target physiological data can be determined based on the mapping relationship; then, the stimulation current intensity and stimulation duration corresponding to each transcranial electrical stimulation data in m transcranial electrical stimulation data can be determined to obtain m stimulation current intensities and m stimulation durations. Taking the first transcranial electrical stimulation data as an example, all stimulation intensities contained in the first transcranial electrical stimulation data can be determined first to obtain at least one stimulation intensity, and the average value of the at least one stimulation intensity is determined, that is, the stimulation current intensity corresponding to the first transcranial electrical stimulation data; then, the duration of the at least one stimulation intensity in the first transcranial electrical stimulation data can be determined to obtain at least one duration, and the at least one duration is added together to obtain the stimulation duration corresponding to the first transcranial electrical stimulation data.

[0054] Furthermore, the m stimulation current intensities can be multiplied by the corresponding stimulation durations among the m stimulation durations to obtain m electrical stimulation amounts; then, the starting stimulation moment corresponding to each stimulation duration among the m stimulation durations can be determined to obtain m starting stimulation moments. Specifically, each piece of transcranial electrical stimulation data can include a timestamp, and the timestamp of each transcranial electrical stimulation occurrence can be obtained from the m pieces of transcranial electrical stimulation data to obtain m timestamps, i.e., m starting stimulation moments; then, curve fitting can be performed based on the m starting stimulation moments and the m electrical stimulation amounts to obtain a target curve. Specifically, the m starting stimulation moments and the corresponding electrical stimulation amounts among the m electrical stimulation amounts can be combined to obtain m coordinate points. Then, a curve fitting method (for example, a polynomial fitting method, a spline method, etc.) can be used to fit these m coordinate points to obtain a target curve.

[0055] Next, the first-order derivatives corresponding to the m starting stimulation moments in the target curve can be determined to obtain m first-order derivatives. Specifically, for each of the m starting stimulation moments, according to its position in the target curve, a suitable numerical differentiation method (e.g., forward difference method, backward difference method, central difference method) is selected to calculate the corresponding first-order derivative, thereby obtaining m first-order derivatives. For example, for the coordinate point (x j ,y j ), j is an integer greater than 0 and less than m. If j=1, it means that the point is the first point among the m coordinate points, and the forward difference method can be used to calculate the corresponding first-order derivative. If j is greater than 1 and less than m, it means that the point is a point in the middle of the m coordinate points, and the central difference method can be used to calculate the corresponding first-order derivative. If j=m, it means that the point is the last point among the m coordinate points, and the backward difference method can be used to calculate the corresponding first-order derivative.

[0056] Next, the average value of m first-order derivatives, that is, the average first-order derivative, can be calculated; then, the target optimization factor corresponding to the average first-order derivative can be determined. Specifically, a mapping relationship between a preset first-order derivative and an optimization factor can be pre-stored, and the target optimization factor corresponding to the average first-order derivative can be determined based on the mapping relationship, wherein the value range of the target optimization factor can be -0.2~0.2; finally, the initial tolerance can be optimized according to the target optimization factor, and the specific calculation formula is as follows: Target tolerance = initial tolerance × (1 + target optimization factor); According to the above formula, the target tolerance can be obtained.

[0057] In this way, by determining the initial tolerance corresponding to the target physiological data and combining multiple factors such as the stimulation current intensity and stimulation duration in the transcranial electrical stimulation data to calculate the amount of electrical stimulation, the impact of key parameters in the transcranial electrical stimulation process on tolerance is fully considered. This multi-factor comprehensive analysis can more accurately reflect the actual tolerance of individuals to transcranial electrical stimulation, avoiding the one-sidedness that may be caused by considering only a single factor.

[0058] Optionally, in determining the three positions of the three electrodes on the target subject's brain according to the reference stimulation current direction, please refer to Figure 4 , Figure 4 is a flow chart of a method for determining an electrode position provided in an embodiment of the present application. Figure 4 As shown, the control unit is specifically used for: C1. Obtain the preset brain map; C2. Acquiring a target stimulation area of ​​the target subject's brain; C3, determining the position of the target stimulation area in the preset brain map to obtain the target stimulation position; C4. Determine the three positions corresponding to the three electrodes on the target object's brain according to a preset electrode positioning method, the target stimulation position and the first stimulation current direction.

[0059] In the embodiment of the present application, the preset brain map and the preset electrode positioning method can be preset or defaulted in advance.

[0060] In a specific embodiment, a preset brain map can be obtained first; then, the target stimulation area of ​​the target object's brain can be obtained. Specifically, the target stimulation area can be determined according to the preset stimulation target. For example, if the target object has motor dysfunction, such as limb movement disorder after stroke, the preset stimulation target is to promote motor function recovery, and the primary motor cortex (M1), supplementary motor area (SMA), premotor area (PM) and other brain areas are key brain areas for controlling movement. M1 is located in the precentral gyrus and directly controls the movement of various parts of the body; SMA and PM are involved in the planning and preparation of movement, and these brain areas can be used as target stimulation areas to promote neuroplasticity of movement-related brain areas and improve motor function through transcranial electrical stimulation.

[0061] Further, the position of the target stimulation area in the preset brain map can be found to obtain the target stimulation position. For example, the target position range corresponding to the target stimulation area in the preset brain map can be first determined, and the center position of the target position range can be used as the target stimulation position. Finally, the three positions corresponding to the three electrodes on the target subject's brain can be determined according to the preset electrode positioning method, the target stimulation position and the first stimulation current direction. For example, the preset electrode positioning method can be a 10-20 electrode system. Assuming that the target stimulation position is located in the left dorsolateral prefrontal cortex (DLPFC) after positioning, roughly on the lateral side of the frontal lobe, close to the area between the precentral gyrus and the superior frontal gyrus, and it is known that the direction of the first stimulation current is from the left DLPFC to the corresponding area on the right, the steps for determining the positions of the three electrodes (including the reference electrode, the stimulation electrode, and the return electrode) based on the 10-20 electrode system are as follows: Determine the position of the reference electrode FPz: Position FPz (midpoint of the forehead) is usually selected as the position of the reference electrode. It is located at the midpoint of the forehead hairline and is a standard position in the 10-20 electrode system. It can provide a stable reference point for the positioning of other electrodes.

[0062] Determine the position of the stimulation electrode F3: According to the naming rules of the 10-20 electrode system and the target stimulation position, position F3 can be selected as the position of the stimulation electrode. Position F3 is located in the left frontal lobe, specifically the left 1 / 4 of the line from position FPz to position Cz (central midpoint). This position is closer to the left DLPFC and can effectively stimulate the target stimulation position. Since the direction of the stimulation current is from the left DLPFC to the right, the current will flow out from position F3.

[0063] Determine the position of the return electrode F4: In order to form a current loop, a return electrode position needs to be determined. According to the current direction and the symmetry of the brain, the position F4 corresponding to the right side can be selected as the position of the return electrode. Position F4 is symmetrical with position F3 about the midline and is located at the right 1 / 4 of the line from position FPz to position Cz. The current will flow in from here, forming a stimulation current loop from left to right, acting on the target stimulation position.

[0064] Through the above steps, the corresponding positions of the three electrodes on the target object's brain are determined according to the 10-20 electrode system, the target stimulation position and the direction of the first stimulation current, namely, the reference electrode position FPz, the stimulation electrode position F3 and the return electrode position F4. In actual operation, the electrode positions can also be fine-tuned according to the differences in individual brain structures and the specific stimulation effects. For example, in order to make the three electrodes equivalent to the target object's brain as a three-phase star circuit, the stimulation electrode position F3 and the return electrode position F4 can be appropriately moved outward to make the angle between each two adjacent positions in position F3, position FPz and position F4 closer to 120 degrees. At the same time, it is necessary to ensure that the above three electrodes are still within the range that can effectively stimulate the target stimulation position.

[0065] In this way, by clarifying that the target stimulation area is for a specific research purpose or clinical need. Determining the target stimulation area through various neuroimaging techniques or functional assessment methods can make the research or treatment more targeted. The benefit is that it can focus on brain areas related to specific functions or diseases, avoid unnecessary stimulation or intervention of irrelevant areas, and improve research efficiency and treatment effects. For example, when treating depression, by accurately locating the brain area related to emotion regulation as the target stimulation area, the symptoms of the target subject can be more effectively improved.

[0066] The stimulation unit is used to stimulate the target object according to the first stimulation scheme through the transcranial electrical stimulation device to obtain second EEG data.

[0067] In the embodiments of the present application, the transcranial electrical stimulation device may include one of the following: a transcranial direct current stimulator, an electroencephalographic bionic stimulator, a transcranial alternating current stimulator, a transcranial random noise stimulation device, etc., which are not limited here.

[0068] In a specific embodiment, within the second time period, the stimulation unit can issue a control instruction to the transcranial electrical stimulation device to control the transcranial electrical stimulation device to output a stimulation current of a first stimulation current intensity in a first stimulation current direction to stimulate the target object, so that the target object generates corresponding EEG data. Then, these EEG data can be collected by the acquisition unit to obtain second EEG data.

[0069] It should be explained that the start time of the second time period is later than the end time of the first time period.

[0070] The control unit is also used to determine whether the preset stimulation target is achieved based on the first EEG data and the second EEG data; when the preset stimulation target is not achieved, determine the second stimulation current direction based on the first EEG data, the second EEG data and the preset stimulation target; and adjust the first stimulation current direction to the second stimulation current direction.

[0071] In the embodiment of the present application, the control unit can analyze the first EEG data and the second EEG data to determine whether the preset stimulation target has been achieved; when the preset stimulation target has been achieved, it means that the first stimulation scheme meets the requirements, and there is no need to proceed to the next step and the program ends directly.

[0072] When the preset stimulation target is not achieved, the second stimulation current direction can be determined based on the first EEG data, the second EEG data and the preset stimulation target; then, the first stimulation current direction is adjusted to the second stimulation current direction.

[0073] In one embodiment, after adjusting the first stimulation current direction to the second stimulation current direction, the stimulation unit is also used to stimulate the target object by outputting a stimulation current of the first stimulation intensity in the second stimulation current direction through a transcranial electrical stimulation device to achieve a preset stimulation target.

[0074] Optionally, in determining the second stimulation current direction according to the first EEG data, the second EEG data and the preset stimulation target, the control unit is specifically configured to: D1. Obtaining a first indicator corresponding to the first EEG data; D2. Obtaining a second indicator corresponding to the second EEG data; D3. Determine the difference between the second indicator and the first indicator to obtain a first difference; D4, determining the preset indicator variation range corresponding to the preset stimulation target; D5. Determine the target upper limit and target lower limit corresponding to the preset indicator variation range; D6. When the first difference is greater than the target upper limit, determining the difference between the first difference and the target upper limit to obtain a second difference; adjusting the first stimulation current direction according to the second difference to obtain the second stimulation current direction; D7. When the first difference is less than the target lower limit, determine the difference between the first difference and the target lower limit to obtain a third difference; adjust the first stimulation current direction according to the third difference to obtain the second stimulation current direction.

[0075] In the embodiment of the present application, the first indicator may include one of the following: frequency domain indicators (for example, δ wave power, θ wave power, α wave power, β wave power, etc.), average amplitude, peak-to-peak value, zero crossing rate, etc., which are not limited here.

[0076] It needs to be explained that the indicators involved in the first indicator, the second indicator, and the preset indicator variation range are consistent in type, that is, they all belong to the same category of data or feature description methods. For example, assuming that the first indicator is the delta wave power of the first EEG data, the second indicator can be the delta wave power of the second EEG data, and the preset indicator variation range is a reasonable variation range set for the delta wave power.

[0077] In a specific embodiment, a first indicator corresponding to the first EEG data can be obtained. Specifically, a filtering technology can be used to remove high-frequency or low-frequency noise. For example, a bandpass filter is used to retain signals within a specific frequency range and remove power supply interference of 50 Hz or 60 Hz. Then, a first acquisition method corresponding to the first indicator can be obtained. The mapping relationship between a preset indicator and an acquisition method can be pre-stored. The first acquisition method corresponding to the first indicator is determined based on the mapping relationship. The first EEG data is processed by the first acquisition method to obtain the first indicator. For example, assuming that the first indicator is a frequency domain indicator, the first acquisition method can be a frequency spectrum. The estimation method is specifically, converting the first EEG data from the time domain to the frequency domain through fast Fourier transform (FFT) to obtain the frequency spectrum of the first EEG data, and calculating the amplitude and phase information of different frequency components through FFT, and calculating the power spectrum according to the FFT result, that is, the power distribution of the EEG signal (that is, the first EEG data) at each frequency, thereby obtaining the frequency domain index, that is, the first index. For example, the power of different frequency bands such as α wave (8~13Hz), β wave (14~30Hz), θ wave (4~7Hz) and δ wave (0.5~3Hz) can be calculated by integrating or summing the power spectrum values ​​in the corresponding frequency bands.

[0078] Next, a second indicator corresponding to the second EEG data can be obtained. Similarly, the method for obtaining the second indicator can be the same as the method for obtaining the first indicator; further, the difference between the second indicator and the first indicator can be determined to obtain the first difference. Specifically, the first difference can be obtained by subtracting the first indicator from the second indicator. Then, the preset indicator variation range corresponding to the preset stimulation target can be determined. Specifically, a mapping relationship between the preset stimulation target and the indicator variation range can be pre-stored, and the preset indicator variation range corresponding to the preset stimulation target is determined based on the mapping relationship. Then, the maximum value (i.e., the target upper limit) and the minimum value (i.e., the target lower limit) in the preset indicator variation range can be determined.

[0079] When the first difference is greater than the target upper limit, the difference between the first difference and the target upper limit can be determined to obtain the second difference. Specifically, the target upper limit can be subtracted from the first difference to obtain the second difference. The direction of the first stimulation current is adjusted according to the second difference to obtain the second stimulation current direction. Specifically, when the first difference is greater than the target upper limit, it means that the current stimulation level is too strong, resulting in excessive excitation of neurons. At this time, the current direction can be adjusted to a direction that can activate other brain regions that have inhibitory connections with the currently stimulated brain region (i.e., the brain region corresponding to the target stimulation area) to obtain the second stimulation current direction. In this way, the activity of the currently stimulated brain region can be regulated through the interaction between brain regions to restore it to a normal level (i.e., the first difference returns to the preset indicator variation range). For example, if the currently stimulated brain region is the prefrontal cortex, when the stimulation is excessive, the current direction can be adjusted to a direction that can activate the parietal cortex that has an inhibitory connection with it to obtain the second stimulation current direction. The excitation level of the prefrontal cortex is reduced by the inhibitory effect of the parietal cortex on the prefrontal cortex, thereby reducing the value of the first difference and returning it to the preset indicator variation range.

[0080] When the first difference is less than the target lower limit, the difference between the first difference and the target lower limit is determined to obtain a third difference. Specifically, the second difference can be obtained by subtracting the target lower limit from the first difference. The direction of the first stimulation current is adjusted according to the third difference to obtain the second stimulation current direction. Specifically, when the first difference is less than the target lower limit, it means that the current stimulation effect does not meet expectations. At this time, the change of the electric field in the target stimulation area after changing the current direction can be calculated according to the preset electric field model, thereby determining in which direction to adjust the current direction to enhance the stimulation effect, thereby obtaining the second stimulation current direction. For example, if the preset electric field model shows that the electric field intensity generated by the first stimulation current direction in the target stimulation area is weak and mainly concentrated on one side (for example, the left side), you can try to tilt the current direction 30 degrees to the other side (for example, the right side) to obtain the second stimulation current direction, so that the electric field is more evenly distributed in the target stimulation area to improve the stimulation effect.

[0081] In this way, by obtaining the first indicator corresponding to the first EEG data and the second indicator corresponding to the second EEG data, and calculating the difference between them (the first difference), the change in brain electrical activity between the two measurements can be accurately quantified. For example, the first indicator and the second indicator can be the average amplitude, frequency, etc. of a specific brain area. The first difference can reflect the specific degree of change of these indicators under different stimulation conditions. In addition, when the first difference is greater than the target upper limit or less than the target lower limit, the second difference or the third difference is further calculated, and the direction of the first stimulation current is adjusted accordingly to obtain the second stimulation current direction, forming a closed-loop feedback adjustment mechanism. This mechanism can dynamically adjust the stimulation parameters (for example, current direction, current intensity) according to the actual response of the brain to the stimulation to achieve a more optimized stimulation effect.

[0082] Optionally, in the aspect of adjusting the first stimulation current direction to the second stimulation current direction, the control unit is specifically configured to: E1. The target object's brain and the three electrodes are equivalent to a target resistance model; the target resistance model is a three-phase star circuit, and the phase difference between each two adjacent phases in the three-phase star circuit is 120 degrees; E2. Adjust the currents of the three electrodes based on the target resistance model and the first stimulation current direction to obtain a target vector synthesis current; the current direction of the target vector synthesis current is the second stimulation current direction, and the current intensity of the target vector synthesis current is the first stimulation current intensity.

[0083] In an embodiment of the present application, the brain of the target object and the three electrodes can be equivalent to a target resistance model. Specifically, the three electrodes can be regarded as three endpoints in a three-phase star circuit, and the brain tissue between each pair of electrodes can be regarded as an equivalent resistor, thereby obtaining a target resistance model; then, the current of each of the three electrodes can be adjusted based on the target resistance model and the direction of the first stimulation current, and the currents of the three electrodes can be vector synthesized to obtain a target vector synthesized current, wherein the current direction of the target vector synthesized current is the direction of the second stimulation current, and the current intensity of the target vector synthesized current is the first stimulation current intensity.

[0084] It should be explained that, in a certain embodiment, the current intensity of the target vector synthetic current may not be the first stimulation current intensity, but the current intensity of the target vector synthetic current may be adjusted according to the actual needs of the target object (for example, the condition of the target object) to achieve a better stimulation effect.

[0085] For an example, see Figure 5 , Figure 5is a schematic diagram of the structure of a target resistance model provided in an embodiment of the present application. It can be seen that the target resistance model is a three-phase star circuit, in which: S: represents the neutral point of the three-phase star circuit, which is the common point where three resistors are connected together; s1, s2, s3: are the three output terminals of the three-phase star circuit, corresponding to the three electrodes of the transcranial electrical stimulation device respectively, from which the stimulation current can be input. Specifically, s1 represents the first electrode, s2 represents the second electrode, and s3 represents the third electrode.

[0086] R1, R2, R3: represent the three load resistors in the three-phase star circuit, specifically the equivalent resistance generated by the three electrodes contacting the target object's brain, for example, the first resistor R1 is the equivalent resistance generated by the brain skin between the first electrode s1 and the neutral point S; the second resistor R2 is the equivalent resistance generated by the brain skin between the second electrode s2 and the neutral point S; the third resistor R3 is the equivalent resistance generated by the brain skin between the third electrode s3 and the neutral point S; It needs to be explained that the circle enclosing the above three load resistors in the target resistance model represents the head, indicating the part of the human body where the electrodes of the transcranial electrical stimulation device act, that is, the current is conducted in the brain tissue to achieve stimulation of the brain nerves.

[0087] In this way, by treating the brain and electrodes as equivalent to a three-phase star circuit, the complex electrophysiological characteristics of the brain can be simulated more accurately. The electrical conduction of brain tissue has certain resistance characteristics. By treating the brain tissue between each pair of electrodes as an equivalent resistor, the resistance differences between different regions and the conduction of current in brain tissue can be taken into account. At the same time, the 120-degree phase difference between each adjacent phase in the three-phase star circuit can reflect the phase relationship of electrical activity in different parts of the brain, which is closer to the actual electrophysiological state of the brain and helps to study and intervene in brain activity more accurately.

[0088] Optionally, in the aspect of adjusting the currents of the three electrodes based on the target resistance model and the first stimulation current direction to obtain a target vector synthesis current, the control unit is specifically used to: E21. Obtaining a first output current of each of the three electrodes corresponding to the direction of the first stimulation current to obtain three first output currents; E22. Determine a first vector synthesis current corresponding to the three first output currents according to the target resistance model; E23. Determine a three-phase stationary coordinate system (a, b, c) corresponding to the target resistance model; E24. The three-phase stationary coordinate system is converted into a two-phase stationary coordinate system (α, β) by Clarke transformation, as follows:

[0089] in, represents the current component of the α-axis in the two-phase stationary coordinate system; I represents the current component of the β axis in the two-phase stationary coordinate system; a I represents the a-phase current in the three-phase stationary coordinate system; b represents the b-phase current in the three-phase stationary coordinate system; E25. Rotate the two-phase stationary coordinate system to a rotating coordinate system (d, q) synchronized with the first vector synthetic current through Park transformation to obtain a direct-axis current and a quadrature-axis current, as follows:

[0090] in, represents the direct axis current; represents the quadrature-axis current; Indicates the preset position angle; E26. determining a first straight-axis current value corresponding to the first stimulation current intensity; E27, determining a first quadrature-axis current value corresponding to the direction of the second stimulation current; E28. Determine a second output current of each of the three electrodes by using an inverse Park transformation, the first direct-axis current value, and the first quadrature-axis current value to obtain three second output currents; E29. Perform vector synthesis on the three second output currents according to the target resistance model to obtain the target vector synthesis current.

[0091] In the embodiment of the present application, the position angle Can be preset or defaulted in advance.

[0092] In a specific embodiment, the first output current of each of the three electrodes corresponding to the direction of the first stimulation current can be obtained first to obtain three first output currents. Specifically, the transcranial electrical stimulation device can include a current sensor. When the transcranial electrical stimulation device executes the first stimulation scheme, the first output current of the above three electrodes is detected by the current sensor to obtain the three first output currents. Then, the first vector synthetic current corresponding to the three first output currents can be determined according to the target resistance model. Specifically, the three first output currents can be expressed in vector form according to the target resistance model. Then, vector calculation is performed on the three first output currents in vector form to obtain the first vector synthetic current. Since vector synthesis is a conventional technology, it will not be repeated here.

[0093] Furthermore, the three-phase stationary coordinate system (a, b, c) corresponding to the target resistance model can be determined. Specifically, the neutral point of the three-phase star circuit can be used as the coordinate origin, and the direction of the coordinate origin pointing to each of the three electrodes is used as the coordinate axis direction, thereby obtaining the three-phase stationary coordinate system (a, b, c); then, the three-phase stationary coordinate system can be converted into a two-phase stationary coordinate system (α, β) by Clarke transformation, as follows:

[0094] in, represents the current component of the α-axis in the two-phase stationary coordinate system; I represents the current component of the β axis in the two-phase stationary coordinate system; a represents the a-phase current in the three-phase stationary coordinate system; I b represents the b-phase current in the three-phase stationary coordinate system; Furthermore, the two-phase stationary coordinate system can be rotated to a rotating coordinate system (d, q) synchronized with the first vector synthetic current through Park transformation to obtain the direct-axis current and the quadrature-axis current, as follows:

[0095] in, represents the direct axis current; represents the quadrature axis current; Indicates the preset position angle; Next, the first straight-axis current value corresponding to the first stimulation current intensity can be determined. Specifically, a mapping relationship between a preset stimulation current intensity and a direct-axis current value can be pre-stored, and the first straight-axis current value corresponding to the first stimulation current intensity can be determined based on the mapping relationship. Then, the first cross-axis current value corresponding to the second stimulation current direction can be determined. Similarly, a mapping relationship between a preset stimulation current direction and a cross-axis current value can be pre-stored, and the first cross-axis current value corresponding to the second stimulation current direction can be determined based on the mapping relationship.

[0096] Then, the second output current of each of the three electrodes can be determined by the inverse Park transformation, the first straight-axis current value and the first quadrature-axis current value to obtain three second output currents. Specifically, the first straight-axis current value and the first quadrature-axis current value can be first converted to a two-phase stationary coordinate system (α, β) by the inverse Park transformation to obtain the first current component of the α-axis and the second current component of the β-axis. Then, the first current component and the second current component can be converted to a three-phase stationary coordinate system (a, b, c) by the inverse Clarke transformation to determine the second output current corresponding to each of the three electrodes to obtain three second output currents. Finally, the three second output currents are vector synthesized according to the target resistance model to obtain a target vector synthesized current. Specifically, since vector synthesis is a conventional technology, it will not be described in detail here.

[0097] For an example, see Figure 6 , Figure 6 : is a structural schematic diagram of a vector current synthesis model provided in an embodiment of the present application, wherein: Point o: represents the coordinate origin of the three-phase stationary coordinate system, and can also be regarded as the reference origin of the current vector, similar to the neutral point in the three-phase star circuit, which is the convergence and reference base point of each current vector.

[0098] I a ,I b ,I c : Respectively represent the current axes of phase A, phase B, and phase C in a three-phase system. They are spaced at a certain angle from each other in space (the angle between each other in an ideal three-phase balanced system is 120 degrees), and are used to determine the direction and position of the current vector in the three-phase system.

[0099] 3 line segments oI on 3 current axes 1 ,oI 2 ,oI 3 : Represent the current vectors of the three-phase currents on their respective phase lines. The length of the line segment represents the magnitude of the current, and the direction of the line segment represents the phase direction of the current. For example, oI 1 It can represent the current vector corresponding to the output current of the first electrode, oI 2 It can represent the current vector corresponding to the output current of the second electrode; oI 3 A current vector corresponding to the output current of the third electrode may be represented; I z :Represents the current vector oI 1 ,oI 2 ,oI 3 The vector synthesis current obtained by vector synthesis; I z The nearby dotted lines represent vector synthesis by vector operation rules (such as the parallelogram rule or the triangle rule), and the dotted arrows represent the direction of the vector synthesis.

[0100] It can be seen that the transcranial electrical stimulation system with variable current direction described in the present application can intuitively understand the impact of transcranial electrical stimulation on brain electrical activity by acquiring the changes in EEG data of the target object in real time during the stimulation process and by comparing the first EEG data and the second EEG data. If the preset stimulation target is not achieved, it means that the current stimulation scheme, especially the stimulation current direction, is not optimal. At this time, it is necessary to adjust the output parameters of the transcranial electrical stimulation device through the control unit to adjust the first stimulation current direction to the second stimulation current direction. Since there is no need to adjust the position of the electrode, complex mechanical operations and repositioning processes are avoided, the adjustment time is greatly shortened, and the direction of the stimulation current can be adjusted simply and quickly under the premise of fixing the electrode position.

[0101] See also Figure 7 , Figure 7 : is a flow chart of a transcranial electrical stimulation method with variable current direction provided in an embodiment of the present application. The method is applied to a transcranial electrical stimulation device, the transcranial electrical stimulation device includes 3 electrodes, and the method may include but is not limited to the following steps: S1, obtaining first EEG data of a target object within a first time period; S2, determining a first stimulation scheme corresponding to the target object according to a preset stimulation target; the first stimulation scheme includes: three positions corresponding to the three electrodes on the target object's brain, a first stimulation current direction, and a first stimulation current intensity; the first stimulation current direction and the first stimulation current intensity are obtained by vector calculation of the currents of the three electrodes; each electrode corresponds to one position; S3, stimulating the target object according to the first stimulation scheme by the transcranial electrical stimulation device to obtain second EEG data; S4. Determine whether the preset stimulation target is achieved based on the first EEG data and the second EEG data; when the preset stimulation target is not achieved, determine the second stimulation current direction based on the first EEG data, the second EEG data and the preset stimulation target; adjust the first stimulation current direction to the second stimulation current direction.

[0102] In a specific implementation, the transcranial electrical stimulation method with variable current direction described in the embodiment of the present invention can also execute other implementations described in the transcranial electrical stimulation system with variable current direction provided in the above-mentioned embodiment of the present invention, which will not be repeated here.

[0103] See also Figure 8 , Figure 8It is a structural schematic diagram of an electronic device provided in an embodiment of the present application, and the electronic device may include a processor, a memory, a communication interface and one or more programs, and the processor, the memory and the communication interface may be interconnected through a bus; the one or more programs are stored in the memory and are configured to be executed by the processor; in the embodiment of the present application, the program includes part or all of the steps for executing the variable current direction transcranial electrical stimulation method.

[0104] An embodiment of the present application also provides a computer-readable storage medium, wherein the computer-readable storage medium stores a computer program for electronic data exchange, wherein the computer program enables a computer to execute part or all of the steps of any method described in the above method embodiments, and the above computer includes an electronic device.

[0105] The embodiment of the present application also provides a computer program product, the computer program product includes a non-transitory computer-readable storage medium storing a computer program, the computer program is operable to cause a computer to execute some or all of the steps of any method described in the method embodiment. The computer program product may be a software installation package, and the computer includes an electronic device.

[0106] It should be noted that, for the aforementioned method embodiments, for the sake of simplicity, they are all expressed as a series of action combinations, but those skilled in the art should be aware that the present application is not limited by the described order of actions, because according to the present application, certain steps can be performed in other orders or simultaneously. Secondly, those skilled in the art should also be aware that the embodiments described in the specification are all preferred embodiments, and the actions and modules involved are not necessarily required by the present application.

[0107] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0108] In the several embodiments provided in the present application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are only schematic, such as the division of the above-mentioned units, which is only a logical function division. There may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the mutual coupling or direct coupling or communication connection shown or discussed can be through some interfaces, and the indirect coupling or communication connection of devices or units can be electrical or other forms.

[0109] Those skilled in the art can understand that to implement all or part of the processes in the above-mentioned embodiments, the processes can be completed by computer programs to instruct related hardware, and the programs can be stored in computer-readable storage media. When the programs are executed, they can include the processes of the above-mentioned method embodiments. The aforementioned storage media include: ROM or random access memory RAM, magnetic disk or optical disk and other media that can store program codes.

[0110] The steps of the method or algorithm described in the embodiments of the present application can be implemented in hardware or by executing software instructions by a processor. The software instructions can be composed of corresponding software modules, and the software modules can be stored in RAM, flash memory, ROM, EPROM, electrically erasable programmable read-only memory (electrically EPROM, EEPROM), registers, hard disks, mobile hard disks, read-only compact disks (CD-ROMs) or any other form of storage medium known in the art. An exemplary storage medium is coupled to the processor so that the processor can read information from the storage medium and write information to the storage medium. Of course, the storage medium can also be a component of the processor. The processor and the storage medium can be located in an ASIC. In addition, the ASIC can be located in a terminal device or a management device. Of course, the processor and the storage medium can also exist in a terminal device or a management device as discrete components.

[0111] Those skilled in the art should be aware that in one or more of the above examples, the functions described in the embodiments of the present application can be implemented in whole or in part by software, hardware, firmware, or any combination thereof. When implemented using software, it can be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer instructions. When the computer program instructions are loaded and executed on a computer, the process or function described in the embodiments of the present application is generated in whole or in part.

[0112] The above-mentioned computer can be a general-purpose computer, a special-purpose computer, a computer network, or other programmable device. The computer instruction can be stored in a computer-readable storage medium, or transmitted from one computer-readable storage medium to another computer-readable storage medium. For example, the computer instruction can be transmitted from a website site, computer, server or data center to another website site, computer, server or data center by wired (such as coaxial cable, optical fiber, digital subscriber line (DSL)) or wireless (such as infrared, wireless, microwave, etc.). The computer-readable storage medium can be any available medium that can be accessed by the computer or a data storage device such as a server or data center that includes one or more available media integrated. Among them, the available medium can be a magnetic medium (for example, a floppy disk, a hard disk, a tape), an optical medium (for example, a digital video disc (DVD)), or a semiconductor medium (for example, a solid state disk (SSD)), etc.

[0113] The modules / units included in the devices and products described in the above embodiments may be software modules / units or hardware modules / units, or may be partially software modules / units and partially hardware modules / units. For example, for the devices and products applied to or integrated in the chip, the modules / units included therein may all be implemented in the form of hardware such as circuits, or at least some of the modules / units may be implemented in the form of software programs, which run on the processor integrated inside the chip, and the remaining (if any) modules / units may be implemented in the form of hardware such as circuits; for the devices and products applied to or integrated in the chip module, the modules / units included therein may all be implemented in the form of hardware such as circuits, and different modules / units may be located in the same component (such as chip, circuit module, etc.) or different components of the chip module, or at least some of the modules / units may be implemented in the form of software programs. It is implemented in the form of a software program that runs on a processor integrated inside the chip module, and the remaining (if any) modules / units can be implemented in hardware such as circuits; for various devices and products applied to or integrated in the terminal equipment, the various modules / units contained therein can be implemented in hardware such as circuits, and different modules / units can be located in the same component (for example, chip, circuit module, etc.) or different components in the terminal equipment, or at least some of the modules / units can be implemented in the form of a software program that runs on a processor integrated inside the terminal equipment, and the remaining (if any) modules / units can be implemented in hardware such as circuits.

[0114] The specific implementation methods described above further illustrate the purpose, technical solutions and beneficial effects of the embodiments of the present application. It should be understood that the above description is only the specific implementation method of the embodiments of the present application and is not intended to limit the protection scope of the embodiments of the present application. Any modifications, equivalent substitutions, improvements, etc. made on the basis of the technical solutions of the embodiments of the present application should be included in the protection scope of the embodiments of the present application.

Claims

1. A transcranial electrical stimulation system with variable current direction, characterized in that: The system is connected to a transcranial electrical stimulation device, the transcranial electrical stimulation device includes three electrodes, and the system includes: an acquisition unit, a control unit, and a stimulation unit, wherein: The acquisition unit is used to acquire first EEG data of the target object within a first time period; The control unit is used to determine a first stimulation scheme corresponding to the target object according to a preset stimulation target; the first stimulation scheme includes: three positions corresponding to the three electrodes on the brain of the target object, a first stimulation current direction, and a first stimulation current intensity; the first stimulation current direction and the first stimulation current intensity are obtained by vector calculation of the currents of the three electrodes; each electrode corresponds to one position; The stimulation unit is used to stimulate the target object according to the first stimulation scheme through the transcranial electrical stimulation device to obtain second EEG data; The control unit is also used to determine whether the preset stimulation target is achieved based on the first EEG data and the second EEG data; when the preset stimulation target is not achieved, determine the second stimulation current direction based on the first EEG data, the second EEG data and the preset stimulation target; and adjust the first stimulation current direction to the second stimulation current direction.

2. The system according to claim 1, characterized in that In the aspect of determining the second stimulation current direction according to the first EEG data, the second EEG data and the preset stimulation target, the control unit is specifically used for: Obtaining a first indicator corresponding to the first EEG data; Obtaining a second indicator corresponding to the second EEG data; Determine a difference between the second indicator and the first indicator to obtain a first difference; Determine a preset indicator variation range corresponding to the preset stimulation target; Determine the target upper limit and target lower limit corresponding to the preset indicator variation range; When the first difference is greater than the target upper limit, determining the difference between the first difference and the target upper limit to obtain a second difference; adjusting the first stimulation current direction according to the second difference to obtain the second stimulation current direction; When the first difference is less than the target lower limit, determining the difference between the first difference and the target lower limit to obtain a third difference; The first stimulation current direction is adjusted according to the third difference to obtain the second stimulation current direction.

3. The system according to claim 1, characterized in that In terms of adjusting the first stimulation current direction to the second stimulation current direction, the control unit is specifically configured to: The brain of the target object and the three electrodes are equivalent to a target resistance model; the target resistance model is a three-phase star circuit, and the phase difference between each two adjacent phases in the three-phase star circuit is 120 degrees; The currents of the three electrodes are adjusted based on the target resistance model and the first stimulation current direction to obtain a target vector synthesis current; the current direction of the target vector synthesis current is the second stimulation current direction, and the current intensity of the target vector synthesis current is the first stimulation current intensity.

4. The system according to claim 3, characterized in that In the aspect of adjusting the currents of the three electrodes based on the target resistance model and the first stimulation current direction to obtain the target vector synthesis current, the control unit is specifically used for: Obtaining a first output current of each of the three electrodes corresponding to the direction of the first stimulation current to obtain three first output currents; Determine a first vector synthesis current corresponding to the three first output currents according to the target resistance model; Determine a three-phase stationary coordinate system (a, b, c) corresponding to the target resistance model; The three-phase stationary coordinate system is converted into a two-phase stationary coordinate system (α, β) by Clarke transformation, as follows: in, represents the current component of the α-axis in the two-phase stationary coordinate system; I represents the current component of the β axis in the two-phase stationary coordinate system; a I represents the a-phase current in the three-phase stationary coordinate system; b represents the b-phase current in the three-phase stationary coordinate system; The two-phase stationary coordinate system is rotated to a rotating coordinate system (d, q) synchronized with the first vector synthetic current by Park transformation, and a direct-axis current and a quadrature-axis current are obtained, as follows: in, represents the direct axis current; represents the quadrature-axis current; Indicates the preset position angle; determining a first straight-axis current value corresponding to the first stimulation current intensity; determining a first quadrature-axis current value corresponding to the direction of the second stimulation current; Determine the second output current of each of the three electrodes by inverse Park transformation, the first direct-axis current value, and the first quadrature-axis current value, to obtain three second output currents; The three second output currents are vector-synthesized according to the target resistance model to obtain the target vector-synthesized current.

5. The system according to any one of claims 1 to 4, characterized in that: In the aspect of determining the first stimulation scheme corresponding to the target object according to the preset stimulation target, the control unit is specifically used for: Determine a reference stimulation scheme corresponding to the preset stimulation target; the reference stimulation scheme includes: a reference stimulation current direction and a reference stimulation current intensity; Determining three positions of the three electrodes on the target subject's brain according to the reference stimulation current direction; Acquiring target physiological data of the target object; Determining the difference between the target physiological data and the preset physiological data to obtain a target difference; Determining a first adjustment factor corresponding to the target difference; Adjusting the reference stimulation current intensity according to the first adjustment factor to obtain a second stimulation current intensity; Acquiring historical transcranial electrical stimulation data of the target object; determining a target tolerance based on the historical transcranial electrical stimulation data; Determining a second adjustment factor corresponding to the target tolerance; adjusting the second stimulation current intensity according to the second adjustment factor to obtain a third stimulation current intensity; The first stimulation scheme is determined according to the third stimulation current intensity and the reference stimulation current direction.

6. The system according to claim 5, characterized in that The historical transcranial electrical stimulation data includes m pieces of transcranial electrical stimulation data, where m is an integer greater than 1. In determining the target tolerance according to the historical transcranial electrical stimulation data, the control unit is specifically used to: Determining an initial tolerance corresponding to the target physiological data; Determine the stimulation current intensity and stimulation duration corresponding to each of the m pieces of transcranial electrical stimulation data, and obtain m stimulation current intensities and m stimulation durations; each stimulation current intensity corresponds to one stimulation duration; Multiplying the m stimulation current intensities by corresponding stimulation durations among the m stimulation durations to obtain m electrical stimulation amounts; Determine the starting stimulation time corresponding to each stimulation duration in the m stimulation durations to obtain m starting stimulation times; Performing curve fitting according to the m starting stimulation moments and the m electrical stimulation amounts to obtain a target curve; the abscissa of the target curve is the starting stimulation moment, and the ordinate is the electrical stimulation amount; Determine the first-order derivatives corresponding to the m starting stimulation moments in the target curve to obtain m first-order derivatives; Determining an average first-order derivative corresponding to the m first-order derivatives; Determining a target optimization factor corresponding to the average first-order derivative; The initial tolerance is optimized according to the target optimization factor to obtain the target tolerance.

7. The system according to claim 5, characterized in that In the aspect of determining the three positions of the three electrodes on the brain of the target object according to the reference stimulation current direction, the control unit is specifically used for: Get the preset brain map; Acquiring a target stimulation area of ​​the target subject's brain; Determine the position of the target stimulation area in the preset brain map to obtain the target stimulation position; The three positions corresponding to the three electrodes on the target object's brain are determined according to a preset electrode positioning method, the target stimulation position and the first stimulation current direction.

8. A method for transcranial electrical stimulation with variable current direction, characterized in that: Applied to a transcranial electrical stimulation device, the transcranial electrical stimulation device includes three electrodes, and the method includes: Acquire first EEG data of the target object within a first time period; Determine a first stimulation scheme corresponding to the target object according to a preset stimulation target; the first stimulation scheme includes: three positions corresponding to the three electrodes on the target object's brain, a first stimulation current direction, and a first stimulation current intensity; the first stimulation current direction and the first stimulation current intensity are obtained by vector calculation of the currents of the three electrodes; each electrode corresponds to one position; Stimulating the target object according to the first stimulation scheme by the transcranial electrical stimulation device to obtain second EEG data; Determine whether the preset stimulation target is achieved based on the first EEG data and the second EEG data; when the preset stimulation target is not achieved, determine the second stimulation current direction based on the first EEG data, the second EEG data and the preset stimulation target; adjust the first stimulation current direction to the second stimulation current direction.

9. An electronic device, characterized in that: include: A processor, a memory, a communication interface, and one or more programs; The one or more programs are stored in the memory and configured to be executed by the processor, the programs comprising instructions for executing the steps in the method of claim 8.

10. A computer-readable storage medium, characterized in that: A computer program for electronic data exchange is stored, wherein the computer program causes a computer to execute the method as claimed in claim 8.

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