Automatic stirring device for quantitative urine protein specimen

Abstract

The invention relates to the technical field of diluting, dispersing or mixing samples, and discloses a urine protein quantitative specimen automatic stirring device which comprises a stirring rod, an input unit, a control unit and a stirrer used for driving the stirring rod to rotate. The control unit is used for receiving different signals sent by the input unit to control the stirrer to drive the stirring rod to rotate; a cylindrical stirring paddle is arranged at the lower part of the stirring rod, a one-way valve plate is arranged at one end of the cylindrical stirring paddle, and when the one-way valve plate is opened, a valve port for fluid to pass through is smaller than the diameter of other parts in the cylindrical stirring paddle. The technical problems that in the prior art, a urine sample of a patient cannot be accurately and stably stirred, the content of urine protein cannot be reflected truthfully, the detection accuracy is reduced, and a doctor has deviation in illness state judgment are solved.

Description

Technical Field

[0001] The invention relates to the technical field of diluting, dispersing or mixing samples, and in particular to an automatic stirring device for urine protein quantitative specimens. Background Art

[0002] The detection of urine protein is of great significance in guiding the treatment of chronic kidney disease, evaluating the treatment effect and judging the prognosis; the 24-hour urine protein quantification method is the most accurate method for measuring urine protein. The collection time span of 24-hour urine specimens is long. During the collection process, the protein in the urine may precipitate and aggregate, resulting in uneven distribution; in order to ensure that the test results can truly reflect the actual content of protein in urine, the urine protein quantification specimen needs to be stirred. By stirring, the protein in the urine can be evenly dispersed throughout the specimen, making the test sample more representative, thereby improving the accuracy of the test results.

[0003] In traditional urine protein testing, patients purchase large-capacity plastic measuring cups to collect urine specimens for 24 hours. The main stirring and dispersion methods include: medical staff or patients directly hold the measuring bucket for collecting urine, and make the urine flow in the bucket by shaking and rotating it back and forth to promote uniform distribution of protein. Alternatively, a disposable wooden stick or a stirring stick such as a glass rod or a plastic rod can be inserted into the urine container, and the urine can be rotated by manually turning the stirring stick to achieve protein mixing, and then samples can be taken from the mixed urine specimen for testing. Stirring sticks such as glass rods and plastic rods can also be washed and reused. However, the above methods all have the problem of uneven stirring.

[0004] With the continuous development of technology in this field, the prior art with announcement number CN212275305U discloses a 24-hour urine trace total protein or albumin quantitative specimen collection device. When stirring and mixing the 24-hour urine, pour the urine into the barrel, cover the cover, and extend the lower end of the clamp into the blind groove; secondly, turn the handle to drive the upper shaft to rotate, and the rotation of the upper shaft drives the lower shaft to rotate through the clamp, and the rotation of the lower shaft drives the stirring paddle to stir and mix the 24-hour urine. The prior art with announcement number CN112504769B discloses a urine sampler for interval urine protein detection in cardiovascular medicine. Through the cooperation of the stirring mechanism and the transmission mechanism, it can automatically sample people's urine, which is convenient for people to use.

[0005] However, the prior art still has the following technical problems:

[0006] 1. The existing stirring and dispersing method is mainly for medical staff to perform rotating stirring, but it is still difficult to ensure the consistency of stirring strength and time. This requires the testers to operate more carefully, stir multiple times and try to maintain the consistency of operation, which is demanding for personnel. In actual work, it is very easy to have unstable stirring, which in turn reduces the accuracy of subsequent testing.

[0007] 2. When patients suffer from kidney diseases such as polycystic kidney disease and lupus nephritis, in addition to protein, the urine may also contain a large amount of cell fragments, casts and other substances; these substances will affect the distribution of protein. If the stirring is not sufficient, the urine protein content cannot be accurately detected. The immune complexes in the urine of patients with lupus nephritis may bind to the protein, and it is difficult to disperse them evenly using the same stirring. Relatively longer stirring is required to allow the protein to be fully exposed and ensure that the test results can truly reflect the condition. For patients with urinary tract infections, there are bacteria and inflammatory secretions in the urine, and ordinary stirring is also difficult to disperse them evenly. In order to stir sufficiently to expose the protein more fully, too many bubbles may be generated at the same time, which seriously affects the accuracy of the test; therefore, it is necessary to control the stirring intensity and speed to avoid excessive bubbles interfering with the test, while ensuring that the protein is evenly distributed.

[0008] 3. In addition, for patients with special physiological conditions, for example, pregnant women’s urine may contain more mucus and other substances. Excessive stirring may destroy the protein structure and affect the test results. Pregnant women may need to undergo frequent urine protein tests, and the accuracy and stability of the stirring operation are more important to accurately judge kidney function and health status during pregnancy. The urine sample volume of newborns is usually small, and the kidney function is not yet fully mature. The protein content and composition in the urine are different from those of adults. When testing neonatal urine protein, the stirring should be precise and gentle, ensuring that the protein is evenly distributed, and the sample should not be damaged due to excessive stirring, so as to obtain accurate test results and assist in the evaluation of the kidney development of the newborn.

[0009] In summary, the existing technology cannot accurately and stably stir the patient's urine specimen, and it is very easy to cause unstable stirring, which in turn reduces the accuracy of subsequent testing. In addition, the existing technology is also unable to accurately stir the urine specimens of different patients, and there is a situation where the urine protein content cannot be accurately reflected, which reduces the accuracy of the test and causes the doctor to deviate from the judgment of the condition. Summary of the invention

[0010] The present invention aims to provide an automated stirring device for urine protein quantitative specimens to solve the technical problem that the prior art has no way to accurately and stably stir the patient's urine specimen, resulting in failure to accurately reflect the urine protein content, reducing the accuracy of the test and causing the doctor to deviate from the diagnosis of the disease.

[0011] In order to achieve the above object, the present invention adopts the following technical scheme:

[0012] An automated stirring device for urine protein quantitative specimens comprises a stirring rod, an input unit, a control unit and a stirrer for driving the stirring rod to rotate, wherein the input unit is used to send a signal for starting stirring, and the control unit is used to receive different signals sent by the input unit to control the stirrer to drive the stirring rod to rotate; a cylindrical stirring paddle is arranged at the lower part of the stirring rod, and a one-way valve plate is arranged at one end of the cylindrical stirring paddle, and when the one-way valve plate is opened, the valve opening for fluid to pass through is smaller than the diameter of the rest of the inner part of the cylindrical stirring paddle.

[0013] Preferably, as an improvement, the input unit is a plurality of buttons arranged on the agitator housing, each button corresponding to a different rotation signal; the agitator is a motor arranged above the stirring rod, a main magnetic rotor is fixedly connected to the power output shaft of the motor, and a secondary magnetic rotor is fixedly connected to the stirring rod; the motor is fixedly set on the top of the frame; or the agitator is a magnetic agitator, and a container for holding a liquid specimen is placed on the top surface of the magnetic agitator; a magnetic stirrer adsorbed to the magnetic element inside the magnetic agitator is arranged at the bottom of the stirring rod.

[0014] Preferably, as an improvement, the one-way valve plate is an elastic plate, any side or the lower side of the elastic plate is fixedly connected to the inner wall of the cylindrical stirring paddle, and the rest of the elastic plate is in tight contact with the inner wall of the cylindrical stirring paddle.

[0015] Preferably, as an improvement, the one-way valve plate includes a valve plate body and an elastic member arranged at the bottom of the valve plate body, and the elastic member is fixed to the cylindrical stirring paddle by a bracket.

[0016] Preferably, as an improvement, it further comprises a frame, on which is provided a slot for limiting the stirring rod; when the stirrer is a motor, the motor is fixed on the frame.

[0017] Preferably, as an improvement, the cylindrical stirring paddle is tilted, and its necked end is the lower end; the cylindrical stirring paddle is tilted, and the end where the one-way valve plate is set is the lower end; the lower side of the elastic plate is fixedly connected to the inner wall of the cylindrical stirring paddle.

[0018] Preferably, as an improvement, the cylindrical stirring paddle and the stirring rod are connected by a connecting rod; a connecting platform is provided at the bottom of the stirring rod, a cavity is provided inside the connecting platform, an axial through hole connected to the cavity is provided in the middle of the stirring rod, and a pressing rod is provided in the axial through hole; the connecting rod extends into the cavity, and a protrusion is provided on the side wall of one end of the connecting rod extending into the cavity, the protrusion is provided on the side of the connecting rod extending toward the one-way valve plate, the lower end of the pressing rod is in contact with the protrusion, and the upper end of the pressing rod extends out of the axial through hole.

[0019] Preferably, as an improvement, a tooth-shaped protrusion is provided on a surface of the elastic sheet facing the outside of the cylindrical stirring paddle.

[0020] Preferably, as an improvement, a tooth-like protrusion is provided on the side of the valve plate body facing the outside of the cylindrical stirring paddle; or a tooth-like protrusion is provided on the circumferential edge of the valve plate body, and the tooth-like protrusion on the edge is a flexible protrusion.

[0021] Preferably, as an improvement, the cylindrical stirring paddle is a cylindrical structure or a conical structure; when the cylindrical stirring paddle is a conical structure, a one-way valve plate is provided near the constricted end of the cylindrical stirring paddle.

[0022] Beneficial effects:

[0023] The inventor found that during the test, there were abnormal sample test results. For example, for patients who had been diagnosed with a certain disease, when urine protein was tested, the conclusion was that the urine protein was extremely small, which led to the need for repeated testing. After analysis, the inventor found that this was related to the current unstable stirring mode, so an automatic stirring device for urine protein quantitative samples was designed.

[0024] 1. This technology uses the principle of magnetic stirring and does not require additional containers. The patient can simply place the measuring cup or container for urine specimens purchased by the patient on the magnetic stirrer to achieve stable and precise stirring. The consistency of speed and other operations during the stirring process can be maintained, which can further improve the accuracy of subsequent tests, help doctors accurately judge the condition, improve doctor-patient relationships, and reduce the occurrence of repeated tests.

[0025] 2. This technology uses the principle of magnetic stirring, combined with buttons and control units, so that users can choose different stirring frequencies according to their needs, which is suitable for different patients; for example, different buttons can be selected for newborns, pregnant women, and patients diagnosed with kidney disease. Therefore, this technology can accurately and stably stir urine specimens for different types of patients, and the stirring method for the same type of patients can also be stable and unified, improving the accuracy of detection.

[0026] It is worth emphasizing that the stirring rod of this technology can not only stir the liquid specimen, but also the cylindrical stirring paddle can allow the urine specimen to enter from the one-way valve plate during the stirring process, and when the one-way valve plate is opened, the valve opening for the fluid to pass through is smaller than the diameter of the rest of the inner part of the cylindrical stirring paddle; so that the urine specimen can enter from the constricted end, and when it flows to the wide end, it will produce changes in flow rate and pressure, which can effectively break the pressure balance inside and outside the foam and cause the foam to burst, while the traditional linear stirring rod structure usually does not have this kind of pressure change defoaming mechanism generated by the special structure. Therefore, this technology can also play a role in defoaming during the stirring process, especially for patients with urinary tract infections, which can not only ensure uniform stirring, but also avoid the generation of too many bubbles to interfere with the detection.

[0027] 3. The cylindrical stirring paddle of the present technology can not only be used as a stirring blade and achieve the purpose of defoaming, but also can be used as a container for scooping urine specimens. During the rotation and stirring of the cylindrical stirring paddle, the one-way valve is opened by the push of the liquid. When the stirring is completed, the cylindrical stirring paddle stops rotating, and the one-way valve is gradually reset. The user rotates the cylindrical stirring paddle in the opposite direction, and then scoops out a part of the evenly stirred urine specimen and pours it into the detection container for subsequent detection.

[0028] 4. It is worth noting that when the one-way valve sheet in the present technology is an elastic sheet, since the elastic sheet can open a part of the open end of the cylindrical stirring paddle, urine quickly flows in from this part and then is discharged from the expanded end, which can break the pressure balance inside and outside the foam and cause the foam to burst; and after stopping, the cylindrical stirring paddle is rotated in the opposite direction, and the elastic sheet can return to its original position and it can easily resist the inner wall of the cylindrical stirring paddle to form a chamber for scooping liquid. If a cylindrical straight-tube cylindrical stirring paddle is used, combined with the elastic sheet design, its processing cost is low and the structure is simple. The elastic sheet is used to form a one-way valve sheet, and the valve opening at the elastic sheet naturally forms a narrow mouth entry characteristic; and when the elastic sheet is closed, a small container for scooping out urine specimens is formed, and the effect is significant. If a cylindrical stirring paddle with a conical structure is used, combined with the narrow mouth entry characteristic naturally formed by the valve opening at the elastic sheet, and then entering the cylindrical stirring paddle with a conical transition, the flow rate and pressure changes of the liquid are more gradient, and it also has a better defoaming effect.

[0029] When the one-way valve plate in the present technology is a structure formed by the combination of a valve plate body and an elastic part, when the valve plate body is opened, a valve mouth channel for liquid to pass through is formed between its circumference and the cylindrical stirring paddle. The principle is the same as above, and the valve mouth naturally forms a narrow entry characteristic. As an alternative to the present technology, it has a significant effect.

[0030] 5. In order to better realize scooping urine, the present technology utilizes the cooperation of the pressing rod and the protrusion. After stirring, by pressing the pressing rod, the connecting rod is rotated slightly, thereby driving the flared end of the cylindrical stirring paddle to lift up a certain distance, which is more convenient for storing urine specimens. It is worth emphasizing that the protrusion in the present technology is set on the side wall of the connecting rod, and the rotation angle of the connecting rod is less than 90 degrees, so the cylindrical stirring paddle will always have a certain inclination, thereby reducing the force on the opening side of the one-way valve at the bottom of the cylindrical stirring paddle. In another scheme other than the present embodiment, the cylindrical stirring paddle can also be directly tilted, and the lower side of the elastic sheet is fixedly sealed with the inner wall of the stirring paddle. That is to say, when the cylindrical stirring paddle is used as a small container for scooping liquid, the liquid specimen is mostly located at the lower part of the cylindrical stirring paddle, which can reduce the force on the opening side of the elastic sheet and can scoop liquid more stably. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 This is a schematic diagram of the structure of Example 1 of the present invention.

[0032] Figure 2 This is a logic block diagram of the control unit, buttons and agitator in Example 1 of the present invention.

[0033] Figure 3 It is a front view of embodiment 1 of the present invention.

[0034] Figure 4 for Figure 3 Front view of the stirring rod after it is placed in the measuring cup.

[0035] Figure 5 Figure 3 Schematic diagram of the one-way valve of the middle cylindrical stirring paddle in the open state.

[0036] Figure 6 This is a front view of the cylindrical stirring paddle with a conical structure in Example 1 of the present invention.

[0037] Figure 7 for Figure 6 Schematic diagram of the closed state of the one-way valve of the middle cylindrical stirring paddle.

[0038] Figure 8 for Figure 7 Cross-sectional view of the cylindrical stirring paddle.

[0039] Fig. 9 for Figure 8 Schematic diagram of the one-way valve of the middle cylindrical stirring paddle in the open state.

[0040] Fig.10 It is a schematic diagram of the structure in which tooth-shaped protrusions are arranged on the one-way valve plate.

[0041] Fig.11 This is a schematic diagram of the perspective state of the connection platform in Example 2 of the present invention.

[0042] Fig.12 This is a schematic diagram of the inclined arrangement of the cylindrical stirring paddle in Example 3 of the present invention.

[0043] Fig.13 This is a schematic diagram of the closed state of the one-way valve in Example 4 of the present invention.

[0044] Fig.14 for Fig.13 Schematic diagram of the one-way valve in the open state.

[0045] Fig.15 It is a front view of embodiment 5 of the present invention.

[0046] Fig.16 This is a schematic diagram of the structure of the one-way valve plate in Example 6 of the present invention. DETAILED DESCRIPTION

[0047] The following is further described in detail through specific implementation methods:

[0048] The figure marks in the drawings of the specification include: a stirring rod 1, a cylindrical stirring paddle 11, a one-way valve plate 111, a toothed protrusion 1111, a valve port 1112, a connecting rod 12, a protrusion 121, a connecting platform 13, a pressing rod 14, a pressing spring 141, a magnetic stirring bar 15, a magnetic stirrer 2, a button 21, a frame 3, a positioning rod 31, a limit block 32, a slot 321, a valve plate body 4, an elastic member 5, a bracket 51, a motor 6, a base 61, a main magnetic rotor 62, an auxiliary magnetic rotor 63, and a bevel edge 7.

[0049] The embodiment is basically as shown in the attached Figure 1-10 As shown:

[0050] The automatic stirring device for urine protein quantitative specimen comprises a stirring rod 1, an input unit, a control unit and a stirrer for driving the stirring rod 1 to rotate, wherein the input unit, the control unit and the stirrer are electrically connected. The input unit is used to send a signal to start stirring, and the control unit is used to receive different signals sent by the input unit to control the stirrer to drive the stirring rod 1 to rotate. The input unit is a plurality of buttons 21 arranged on the stirrer housing, each button 21 corresponds to a different rotation signal, and the rotation signal can be stirring for different minutes at the same speed, or stirring for the same minutes at different speeds, or rotating for different specific minutes at different speeds. The number of buttons 21 can be set as needed, and a logo is set on the surface of each button 21, which can be different colors, or the words "low, medium, high", or three categories of "infants, ordinary people, kidney disease", or four categories of "infants, pregnant women, kidney disease, other patients". In this embodiment, four buttons 21 are set as an example, and the logos are "green, blue, yellow and red", green corresponds to infants, blue corresponds to pregnant women, red corresponds to patients with kidney disease, and yellow corresponds to other patients. A display screen is also provided on the stirrer housing to display stirring timing data.

[0051] The control unit is a controller, which can be a PLC controller or a single-chip microcomputer; different stirring template information is stored in the controller, for example, including the following four stirring template information: low-speed stirring for 15 seconds (infants), low-speed stirring for 20 seconds (pregnant women), low-speed stirring for 25 seconds (other patients), and medium-speed stirring for 20 seconds (patients with kidney disease). The above low speed and medium speed can be designed and adjusted according to actual conditions. This embodiment takes the following as an example to illustrate the motor speed (rpm), low speed 50 rpm, about 0.83 rpm; medium speed is 90 rpm, about 1.5 rpm. Each button 21 corresponds to a template information. When the button 21 is pressed, the controller calls different templates for control according to different input signals. Compared with the prior art without classification, medical staff stir each urine sample for about 15 seconds by themselves. This technology can further perform classified stirring, which has a more precise stirring effect to improve the subsequent detection accuracy. In other embodiments other than this embodiment, patients with kidney disease can also use a two-stage stirring mode, such as first rotating at a low speed of 50 rpm for 10 seconds, and then rotating at a medium speed of 90 rpm for 10 seconds to balance the dispersion effect and the risk of mechanical damage. In other embodiments other than this embodiment, the same rotation speed can also be used, but the stirring time for the four patients is different. Therefore, the above template information is only a display and does not play a limiting role. In actual situations, if this set of devices is used, the data can also be set as needed.

[0052] The stirrer is a magnetic stirrer 2, and a container for holding a liquid specimen, such as a measuring cup, is placed on the top surface of the magnetic stirrer 2; a magnetic stirrer 15 adsorbed by the magnetic element inside the magnetic stirrer 2 is welded or bonded to the bottom of the stirring rod 1. In other embodiments other than this embodiment, the magnetic stirrer 15 is detachably connected to the bottom of the stirring rod 1, and the connection method can be that a square or polygonal card slot is set at the center of the bottom end of the stirring rod 1. Taking the square as an example, the center of the top surface of the magnetic stirrer 15 is correspondingly provided with a square protrusion, so that the magnetic stirrer 15 can be clamped and fixed in the card slot; when it needs to be disassembled, the magnetic stirrer 15 can be taken out under external force. After receiving the button 21 signal, the control unit controls the magnetic stirrer 2 to start, and the magnetic stirrer 2 drives the stirring and rotation through the magnetic stirrer 15, thereby realizing the stirring of the urine specimen. During stirring, the medical staff can hold the measuring cup handle, and in other embodiments other than this embodiment, a plurality of limit bars can be installed on the top of the magnetic stirrer 2 for limiting the measuring cup. The limit bar can also be set on a square frame, and downward convex edges are set on both sides of the square frame, and the convex edges can be buckled and clamped on the left and right sides of the magnetic stirrer 2; the limit bar is two or four C-shaped structures symmetrically arranged in pairs. This embodiment takes two as an example, and the two limit bars are respectively fixedly connected to the left and right inner walls of the square frame through rods; and the limit bar can be slidably connected to the rod, and a compression spring can be set in the slide groove, so that the limit bar can be moved according to the sizes of different measuring cup containers, thereby realizing the clamping and fixation of different measuring cups.

[0053] A frame 3 is provided on one side of the agitator. Figure 1 As shown, the frame 3 can be eccentrically arranged on the right side of the rear portion of the top surface of the magnetic stirrer 2; Figure 3 As shown, the frame 3 can also be set at the center of the rear part of the top surface of the magnetic stirrer 2. A positioning rod 31 is vertically penetrated on the frame 3, and the two sides of the positioning rod 31 are threadedly connected with screws that are pressed against the frame 3. A round handle is provided on the screw. When the round handle loosens the screw, the positioning rod 31 can be adjusted up and down. A limit block 32 is provided at the end of the positioning rod 31, and a groove 321 for limiting the stirring rod 1 is provided on the limit block 32. The outer support arm of the groove 321 is made of elastic material and this side is in a closed state when there is no external force. The inner side of the groove 321 forms a through hole in a natural state, and the aperture of the through hole is smaller than the rod diameter of the stirring rod 1, so as not to affect the rotation of the stirring rod 1.

[0054] A cylindrical stirring paddle 11 is provided at the lower part of the stirring rod 1, and the cylindrical stirring paddle 11 is connected to the stirring rod 1 through a connecting rod 12. The one-way valve plate 111 is an elastic plate, and any side or the lower side of the elastic plate is fixedly connected to the inner wall of the cylindrical stirring paddle 11. Figure 5 The lower side of the middle elastic sheet is bonded and fixed to the inner wall of the cylindrical stirring paddle 11. Figure 5The upper side of the elastic sheet is opened inward to form a valve port 1112. The cylindrical stirring paddle 11 can be made of metal or silicone, and stainless steel is preferred in this embodiment. The one-way valve sheet 111 can be any one of a metal sheet, a silicone sheet, and a composite one-way valve sheet 111 with a metal sheet inside and silicone wrapped on the outside. When the one-way valve sheet 111 is a metal sheet, it can be a single metal or a rubber layer wrapped around the circumference of the one-way valve sheet 111, so that when it is reset, the edge can be further tightly sealed against the inner wall of the cylindrical stirring paddle 11. In other embodiments other than this embodiment, the lower side of the elastic sheet is detachably connected to the inner wall of the cylindrical stirring paddle 11, which is convenient for disassembly and replacement of the elastic sheet, and this method should also belong to the protection scope of this technology; specifically, an arc-shaped groove can be set on the inner wall of the end of the cylindrical stirring paddle 11, and the groove wall of the arc-shaped groove can extend to the center of the cylinder. The length of the arc-shaped groove is at least half of the circle of the open end of the cylindrical stirring paddle, and the elastic sheet can be clamped in the arc-shaped groove.

[0055] The cylindrical stirring blade 11 is a cylindrical structure or a conical structure. Figure 3-5 As shown, the cylindrical stirring blade 11 is a cylindrical structure. Figure 6-9 As shown, when the cylindrical stirring paddle 11 is a conical structure, the one-way valve plate 111 is arranged close to the constricted end of the cylindrical stirring paddle 11 .

[0056] The side of the one-way valve plate 111 facing the outside of the cylindrical stirring blade 11 can be a smooth structure, or it can be as Fig.10 As shown, tooth-shaped protrusions 1111 are provided on the surface, and bubbles can be punctured when they come into contact with them, further achieving a defoaming effect. In addition, when providing, tooth-shaped protrusions 1111 can be provided on the entire surface of the surface, or tooth-shaped protrusions 1111 can be provided only on the movable side of the upper part of the elastic sheet, so that when liquid passes through, it comes into contact with tooth-shaped protrusions 1111 to achieve a defoaming effect; these structures should all fall within the protection scope of the present technology.

[0057] The method of using the automatic stirring device for urine protein quantitative specimen is as follows:

[0058] The patient uses a plastic measuring cup container to collect 24-hour urine specimens. You can choose a measuring cup of 3000ml, 4000ml, 5000ml or other capacity. This embodiment takes the highest scale of 5000ml as an example. Under normal circumstances, the 24-hour urine specimen is about 1500ml. The medical staff will place the measuring cup after collecting the urine specimen on the Figure 1On the magnetic stirrer 2 in the mixing bowl, the upper part of the stirring rod 1 is then inserted into the slot 321 on the limit block 32. By pressing the button 21, the control unit controls the magnetic stirrer 2 to start, driving the magnetic stirrer 15 at the bottom of the stirring rod 1 to rotate, thereby driving the entire stirring rod 1 and the cylindrical stirring paddle 11 to rotate to achieve stirring of the urine specimen. During the rotation process, one side of the one-way valve sheet 111 is set in the front, so that the one-way valve sheet 111 will open under the push of the liquid. For example, if the one-way valve sheet 111 is an elastic sheet, Figure 5 As shown, the upper part of the one-way valve sheet 111 is pushed open, and it can be seen that when the one-way valve sheet 111 is opened, the valve port 1112 through which the fluid passes is smaller than the diameter of the rest of the inner part of the cylindrical stirring paddle 11. When the urine specimen enters from the narrowed end and flows toward the widened end, the flow rate and pressure will change, which can effectively break the pressure balance inside and outside the foam and cause the foam to burst. Therefore, this technology can not only ensure uniform stirring, but also avoid the generation of too many bubbles to interfere with the detection.

[0059] Embodiment 2

[0060] The difference between this embodiment and the first embodiment is that Fig.11 As shown, the cylindrical stirring paddle 11 is connected to the stirring rod 1 through a connecting rod 12; a connecting platform 13 is provided at the bottom of the stirring rod 1, a cavity is provided inside the connecting platform 13, an axial through hole connected to the cavity is provided in the middle of the stirring rod 1, and a pressing rod 14 is provided in the axial through hole; the connecting rod 12 extends into the cavity, and a protrusion 121 is provided on the side wall of the end of the connecting rod 12 extending into the cavity, and the protrusion 121 is provided close to the side of the constricted end of the cylindrical stirring paddle 11, the lower end of the pressing rod 14 contacts the protrusion 121, and the upper end of the pressing rod 14 extends out of the axial through hole; and a pressing spring 141 is also provided at the upper end of the pressing rod 14. An annular boss is provided at the end of the connecting rod 12 extending into the cavity, and an annular groove matching it is provided on the inner wall of the cavity, and the connecting rod 12 can rotate in the annular groove but will not fall out of the annular groove. A silicone sleeve is provided outside the connecting platform 13 near the connecting rod 12 , and the two ends of the silicone sleeve are respectively fixed (for example, bonded) to the connecting platform 13 and the outer wall of the connecting rod 12 to form a seal to prevent the urine sample from entering the connecting platform 13 through the gap between the connecting rod 12 and the connecting platform 13 .

[0061] During use, after the urine sample is stirred, it is necessary to scoop the urine sample; press the top of the pressing rod 14, so that the lower end of the pressing rod 14 pushes the protrusion 121 downward, and the connecting rod 12 rotates clockwise, thereby driving the end of the cylindrical stirring paddle 11 away from the one-way valve plate 111 to lift up a distance. Taking the cylindrical stirring paddle 11 with a conical structure as an example, the flared end of the cylindrical stirring paddle 11 is lifted up a distance. Such an inclined setting makes it easier to scoop up urine samples.

[0062] Embodiment 3

[0063] The difference between this embodiment and the first embodiment is that the cylindrical stirring paddle 11 is tilted, and the end where the one-way valve plate 111 is provided is the lower end; the lower side of the elastic plate is fixedly connected to the inner wall of the cylindrical stirring paddle 11. Fig.12 As shown, the cylindrical stirring paddle 11 is a conical structure as an example, and the narrow end of the cylindrical stirring paddle 11 is the low end. Of course, in other embodiments other than this embodiment, the cylindrical stirring paddle 11 can also be a cylindrical structure.

[0064] During the stirring process, the urine sample enters from the narrow valve opening 1112, which can not only achieve the effect of defoaming, but also such an inclined setting makes the urine move in an oblique upward manner, and the stirring is more uniform. In addition, such an inclined setting is also convenient for subsequent scooping of liquid.

[0065] Embodiment 4

[0066] The difference between this embodiment and the first embodiment is that Fig.13 , Fig.14 As shown, the one-way valve plate 111 includes a valve plate body 4 and an elastic member 5 arranged at the bottom of the valve plate body 4. The elastic member 5 is fixed to the cylindrical stirring paddle 11 by a bracket 51. The elastic member 5 is a spring; and the elastic member 5 is covered with a smooth silicone soft layer.

[0067] A toothed protrusion 1111 is provided on one surface of the valve plate body 4 facing the constricted end of the cylindrical stirring paddle 11 ; or a toothed protrusion 1111 is provided on the circumferential edge of the valve plate body 4 , and the toothed protrusion 1111 on the edge is a flexible protrusion 121 .

[0068] Embodiment 5

[0069] The difference between this embodiment and the first embodiment is that Fig.15 As shown, the stirrer includes a motor 6 and a base 61, a frame 3 is fixed on the base 61, the motor 6 is fixed on the frame 3, the base 61 is used to place a container (plastic measuring cup) for holding liquid specimens, a main magnetic rotor 62 is fixedly connected to the power output shaft of the motor 6, and a secondary magnetic rotor 63 is fixedly connected to the top of the stirring rod 1; the button 21 is arranged on the base 61. The secondary magnetic rotor 63 can be fixed to the top of the stirring rod 1 by bonding or welding; of course, a detachable connection method can also be considered, for example, a square protrusion is arranged at the bottom center of the secondary magnetic rotor 63, and a groove is arranged at the top of the stirring rod 1. When installing, the secondary magnetic rotor 63 is buckled and tightened to be fixed to the top of the stirring rod 1.

[0070] When in use, place the plastic measuring cup on the base 61, put the lower end of the stirring rod 1 into the plastic measuring cup, and insert the upper part of the stirring rod 1 into the slot 321 on the limit block 32, start the motor 6, and the auxiliary magnetic rotor 63 at the top of the stirring rod 1 is adsorbed on the main magnetic rotor 62 on the power output shaft of the motor 6, and driven by the motor 6 to rotate, thereby achieving stirring of the specimen; the main magnetic rotor 62 can be a permanent magnetic material or an electromagnet. In order to further improve the stability of stirring, a strip protrusion is radially arranged on the main magnetic rotor 62, and a groove matching it is arranged on the auxiliary magnetic rotor 63 to avoid the risk of falling off during stirring and rotating. It is worth noting that the stirring rod 1 and the cylindrical stirring paddle 11 in the present technology can be made of low-cost materials as disposable consumables or can also be made into reusable materials; for example, the stirring rod 1 and the cylindrical stirring paddle 11 are made of stainless steel, the surface is smooth and not easy to scale, and when reused, a bucket is used to hold the cleaning liquid, and a magnetic stirrer can be used to achieve stirring and cleaning, which is very convenient.

[0071] Embodiment 6

[0072] The difference between this embodiment and the first embodiment is that when the one-way valve sheet 111 is a silicone sheet, the edge of the one-way valve sheet 111 that is not fixedly connected to the cylindrical stirring paddle 11 is a downwardly inclined bevel edge 7, such as Fig.16 The left edge shown is a bevel edge 7; when the liquid rushes in from the outside, the side edge is easier to open, and when it is reset downward, the edge contacts the inner wall of the cylindrical stirring paddle 11. Since it is thinner than other parts, it is easier to deform to achieve a tight contact effect. In other embodiments other than this embodiment, the thinnest position of the edge can also be set to bulge outward more, and when it is reset downward, its edge can be folded upward to further ensure that the edge is in tight contact. In other embodiments other than this embodiment, a coating layer can be coated on the surface of the silicone sheet to improve smoothness and reduce precipitation adhesion; for example, a PTFE film is coated.

[0073] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions and / or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. Urine protein quantitative specimen automatic stirring device, characterized by: It includes a stirring rod, an input unit, a control unit and an agitator for driving the stirring rod to rotate, the input unit is used to send a signal to start stirring, and the control unit is used to receive different signals sent by the input unit to control the agitator to drive the stirring rod to rotate; a cylindrical stirring paddle is arranged at the lower part of the stirring rod, and a one-way valve plate is arranged at one end of the cylindrical stirring paddle, and when the one-way valve plate is opened, the valve opening for fluid to pass through is smaller than the diameter of the rest of the inner part of the cylindrical stirring paddle.

2. The automatic stirring device for urine protein quantitative specimen according to claim 1, characterized in that: The input unit is a plurality of buttons arranged on the outer shell of the blender, each button corresponding to a different rotation signal; The stirrer is a motor arranged above the stirring rod, a main magnetic rotor is fixedly connected to the power output shaft of the motor, and a secondary magnetic rotor is fixedly connected to the stirring rod; the motor is fixedly arranged on the top of the frame; Alternatively, the stirrer is a magnetic stirrer, and the container containing the liquid specimen is placed on the top surface of the magnetic stirrer; A magnetic stirring bar adsorbed to the magnetic element inside the magnetic stirrer is arranged at the bottom of the stirring rod.

3. The automatic stirring device for urine protein quantitative specimen according to claim 2, characterized in that: The one-way valve sheet is an elastic sheet, any side or the lower side of the elastic sheet is fixedly connected to the inner wall of the cylindrical stirring paddle, and the rest of the elastic sheet is in tight contact with the inner wall of the cylindrical stirring paddle.

4. The automatic stirring device for urine protein quantitative specimen according to claim 2, characterized in that: The one-way valve plate comprises a valve plate body and an elastic member arranged at the bottom of the valve plate body, and the elastic member is fixed to the cylindrical stirring paddle via a bracket.

5. The automatic stirring device for urine protein quantitative specimen according to claim 3 or 4, characterized in that: It also includes a frame, on which is provided a slot for limiting the stirring rod; when the stirrer is a motor, the motor is fixed on the frame.

6. The automatic stirring device for urine protein quantitative specimen according to claim 3, characterized in that: The cylindrical stirring paddle is arranged obliquely, and the end where the one-way valve sheet is arranged is the lower end; the lower side of the elastic sheet is fixedly connected to the inner wall of the cylindrical stirring paddle.

7. The automatic stirring device for urine protein quantitative specimen according to claim 5, characterized in that: The cylindrical stirring paddle and the stirring rod are connected by a connecting rod; a connecting platform is provided at the bottom of the stirring rod, a cavity is provided inside the connecting platform, an axial through hole connected to the cavity is provided in the middle of the stirring rod, and a pressing rod is provided in the axial through hole; the connecting rod extends into the cavity, and a protrusion is provided on the side wall of one end of the connecting rod extending into the cavity, the protrusion is provided on the side of the connecting rod extending toward the one-way valve plate, the lower end of the pressing rod is in contact with the protrusion, and the upper end of the pressing rod extends out of the axial through hole.

8. The automatic stirring device for urine protein quantitative specimen according to claim 3, characterized in that: The elastic sheet is provided with tooth-shaped protrusions on one side facing the outside of the cylindrical stirring paddle.

9. The automatic stirring device for urine protein quantitative specimen according to claim 4, characterized in that: A tooth-shaped protrusion is arranged on the side of the valve plate body facing the outside of the cylindrical stirring paddle; or a tooth-shaped protrusion is arranged on the circumferential edge of the valve plate body, and the tooth-shaped protrusion on the edge is a flexible protrusion.

10. The automatic stirring device for urine protein quantitative specimen according to claim 1, characterized in that: The cylindrical stirring paddle is of cylindrical structure or conical structure; when the cylindrical stirring paddle is of conical structure, a one-way valve plate is arranged near the constricted end of the cylindrical stirring paddle.

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