Dapagliflozin production drying machine and drying method thereof

Abstract

The invention provides a drying machine for dapagliflozin production and a drying method of the drying machine, and relates to a drying machine structure, the drying machine comprises a biconical container, a jacket heating layer, a supporting body layer and a spherical rotating body which are sequentially arranged from inside to outside, and the biconical container is of a split type module combined structure and can rotate around the axis of the biconical container; a scraper attached to the inner wall is arranged in the biconical container, the two ends of the horizontal center of the spherical rotating body are erected on an installation frame through a horizontal rotating shaft, a motor set used for driving the horizontal rotating shaft to rotate is arranged on the installation frame, a liquid through hole is formed in the center of the horizontal rotating shaft, and the liquid inlet cavity and the liquid outlet cavity are communicated with the liquid through holes in the two ends respectively. The liquid through hole is further communicated with the heating storage tank through a rotating joint connected to the end of the horizontal rotating shaft, the heating medium in the heating storage tank circulates in the jacket heating layer through a water pump, the drying uniformity and the drying efficiency can be further improved, and the occurrence probability of drying dead corners and wall attachment is reduced.

Description

Technical Field

[0001] The present invention relates to a dryer structure, in particular to a dryer for producing dapagliflozin and a drying method thereof. Background Art

[0002] Dapagliflozin, as a hypoglycemic drug, is used as a monotherapy for adult patients with type 2 diabetes. During its synthesis and production, the centrifuged solid semi-finished product needs to be transferred to a dryer to complete the final drying process. Currently, the equipment commonly used to dry the drug is a double-cone vacuum dryer, and the structure can be seen in the patent "A titanium-lined container for a double-cone vacuum dryer and a double-cone vacuum dryer" (Announcement No. CN116336796B). However, the existing dryers still have the following defects when in use: 1. Material walling problem: that is, the material During drying, it will adhere to the inner wall of the dryer and form a wall, which will not only affect the mass transfer and heat transfer inside the dryer, thereby affecting the properties of the entire batch of materials and causing defective products, but also affect the service life of the dryer; 2. Defects in the heating device: that is, the traditional jacket heating device has the disadvantage of uneven heating, and it is difficult for the heating medium to enter some blind areas of the jacket, affecting product quality and output; 3. Cleaning and sanitation issues: that is, the traditional double-cone rotary vacuum dryer is generally shut down for manual cleaning when dealing with the wall problem, which is time-consuming and labor-intensive, and the cleaning is also difficult. Summary of the invention

[0003] In order to solve the above technical problems, the purpose of the present invention is to provide a dryer and a drying method for the production of dapagliflozin, which can further improve the drying uniformity and drying efficiency and reduce the probability of drying dead corners and wall formation.

[0004] The present invention provides the following technical solutions:

[0005] A dryer for producing dapagliflozin and a drying method thereof, comprising a double-conical container, a jacket heating layer, a support layer and a spherical rotator arranged in sequence from the inside to the outside, the double-conical container being a split-type modular combination structure and being able to rotate around its axis, a scraper arranged in contact with the inner wall is arranged in the double-conical container, when the scraper is separated from the lock with the double-conical container, the double-conical container rotates, and the scraper performs a rotational scraping of the inner wall relative to the double-conical container, the jacket heating layer is sleeved outside the double-conical container, and is used to heat and dry the internal material through the double-conical container, the liquid inlet pipe of the jacket heating layer passes through the support layer to communicate with the liquid inlet cavity of the spherical rotator, and the liquid outlet pipe of the jacket heating layer passes through the support layer to communicate with the spherical rotator The liquid outlet cavity of the spherical swivel is connected, the liquid inlet cavity and the liquid outlet cavity of the spherical swivel are separated by a partition, and the two ends of the horizontal center of the spherical swivel are mounted on a mounting frame through a horizontal rotating shaft, and a motor group for driving the horizontal rotating shaft to rotate is arranged on the mounting frame, and the motor group drives the gear to rotate through the motor to drive the outer gear ring meshed with it and fixed outside the horizontal rotating shaft to rotate, so as to achieve the purpose of driving the horizontal rotating shaft and the spherical swivel to rotate, and a liquid through hole is also arranged at the center of the horizontal rotating shaft, and the liquid inlet cavity and the liquid outlet cavity are respectively connected to the liquid through holes at both ends, and the liquid through hole is also connected to the heating storage tank through a rotating joint connected to the end of the horizontal rotating shaft, and the heating medium in the heating storage tank is circulated in the jacket heating layer through a water pump;

[0006] At this point, the double-conical container of the split module combination and the scraper combination inside it can provide a variety of working modes, so that different working modes can be selected according to the drying conditions of the medicine, so as to reduce the probability of wall formation during work, and the wall formation treatment can be completed during work, and the drying efficiency is also higher. In addition, since the double-conical container can also take into account the rotation around two sets of axis directions at the same time during the drying work, it can further improve the drying uniformity and drying efficiency, and reduce the probability of drying dead corners.

[0007] Preferably, the rotation center of the double-conical container is perpendicular to the rotation center of the spherical rotator, so that when the two axes rotate simultaneously, the material inside can achieve a better uniform dispersion effect.

[0008] Preferably, the double-conical container comprises a first cone, a second cone and a middle ring connecting the first cone and the second cone, the first cone having a material inlet section at the necking end, the first cone having a right-angle slip ring first connected to the middle ring at the flared end, a rotating motor externally connected to the center of the necking end of the second cone, and the second cone having a right-angle slip ring second connected to the middle ring, the middle ring being connected to the spherical swivel via an external swivel, and the first cone and the second cone being detachably connected to the middle ring, one end of the spherical swivel being provided with a sealing plate for encapsulating outside the material inlet section, and the other end being provided with a support seat for supporting and positioning the rotating motor, and at the same time, the first cone and the sealing plate are also detachably connected;

[0009] Therefore, the double-conical container now has three working modes. The first working mode is: the first cone and the second cone are both locked with the middle ring, and the double-conical container can realize overall rotation. The second working mode is: when the first cone is locked and connected with the spherical swivel, the first cone is locked with the middle ring and the second cone is disengaged from the middle ring. At this time, the second cone rotates alone, and the first cone is fixed relative to the middle ring and the spherical swivel. The third working mode is: the first cone is locked and connected with the spherical swivel, the second cone is locked with the middle ring and the first cone is disengaged from the middle ring. At this time, the second cone drives the middle ring to rotate, and the first cone is fixed relative to the spherical swivel.

[0010] Preferably, the scraper is provided with three sections, the first section of the scraper is arranged in contact with the inner wall of the second cone, and its two ends are connected to the bottom side of the middle ring, the distance between the two ends of the first section of the scraper is the diameter distance of the middle ring, that is, the center of the first section of the scraper is colinear with the rotation center of the second cone, the second section of the scraper and the third section of the scraper are connected to the top side of the middle ring, and their top ends are in contact with the surface of the first cone and extend to the port of the material mouth section.

[0011] Preferably, the material mouth section is also provided with a limiting ring for limiting the position of the second and third scraper sections to fit on the inner wall of the first cone, thereby preventing the second and third scraper sections from tilting inward during use and causing them to detach from the first cone.

[0012] Preferably, there are at least two sets of first connecting members for detachably connecting the first cone and the intermediate ring member, second connecting members for detachably connecting the second cone and the intermediate ring member, and third connecting members for detachably connecting the first cone and the spherical rotating body. The structures of the first connecting member, the second connecting member, and the third connecting member are the same, and each includes a pressing plate, a guide block, a plug rod, a pressing cylinder, and a compression spring. The pressing cylinders of the first connecting member and the second connecting member are installed on the middle section ring member, and the pressing cylinder of the third connecting member is installed on the sealing plate. The driving end of the pressing cylinder presses the compression spring through the pressing plate. The pressing plate is guidingly connected to the guide block, and a plug rod for passing through the intermediate ring member or the sealing plate and inserting into the first right-angle sliding ring or the second right-angle sliding ring or the material port section is fixed thereon. One right-angle side of the guide block is fixedly connected to the middle section ring member or the sealing plate, and the other right-angle side is parallel to the pressing plate for pressing the compression spring;

[0013] Thus, when it is necessary to release the locking, the pressing cylinder can be driven to press the pressing plate, thereby driving the plug rod to disengage from the corresponding first cone or second cone. When it is necessary to lock, the pressing cylinder retracts, and the pressing plate drives the plug rod to pass through the intermediate ring member or the sealing plate and abut against the first cone or the second cone under the pressing of the compression spring. When the first cone or the second cone rotates into place and the hole positions are aligned, the plug rod is inserted into the corresponding hole position to achieve connection and locking. At this time, if both the first cone and the second cone are in a state of releasing the locking relative to the intermediate ring member, it is necessary to first complete the locking of the second cone and the intermediate ring member, then perform the locking connection of the first cone and the intermediate ring member, and then perform the locking of the first cone and the sealing plate.

[0014] Preferably, the end of the material port section is sealed by a sealing cover. A vacuum pipe opening communicating with the double-cone container is provided inside the sealing cover. A vacuum unit for evacuating is also provided on the sealing cover. The vacuum unit uses a vacuum pump or a centrifugal fan. This structure is prior art and will not be elaborated here. One end of the sealing cover is rotatably installed outside the spherical rotating body through a pin shaft, and a set of driving cylinders is also hingedly installed at its end. The other end of the driving cylinder is also hingedly installed outside the spherical rotating body, and the hinge axes of the driving cylinder, the sealing cover, and the spherical rotating body are parallel to the pin shaft. Therefore, by starting the driving cylinder, the sealing cover can be rotated around the pin shaft to seal or open the material port section. When it is opened, the material port section faces upward for butt-loading and downward for butt-unloading.

[0015] Preferably, a first sealing ring for sealing is provided at the covering end of the sealing cover and the material port section, and a second sealing ring for rotary sealing is provided between the first cone and the second cone and the middle section ring member.

[0016] Preferably, the jacket heating layer is divided into two groups of heating units which are respectively arranged outside the first cone and the second cone. The heating units are connected to the inner ring of the spherical rotator through a support layer, and a sliding surface is also provided on the inner side thereof so that they can slide more smoothly relative to the first cone and the second cone.

[0017] A drying method of a dryer for the production of dapagliflozin, based on the above-mentioned dryer for the production of dapagliflozin, comprises the following steps:

[0018] First, the spherical swivel is driven to rotate so that the port of the material inlet section is at the top to facilitate docking and loading. At this time, the centrifugal solid-dapagliflozin semi-finished product rinsed with ethanol is transferred to this double-conical container, and the loading amount is controlled at 30%-50% of the volume of the double-conical container to avoid excessive drying, motor overload, and even damage to the vacuum system. During loading, the double-conical container is in a transitional working mode. In this working mode, the second cone is locked with the middle ring and the first cone is unlocked from the middle ring, and the rotation is started. When the motor is turned, the second cone drives the middle ring and the scraper to rotate, while the first cone is fixed relative to the spherical swivel. Initially, there is no wall. At this time, the second cone drives the scraper to rotate synchronously to achieve solid shaking during loading and avoid accumulation of falling materials. The first cone is fixed to facilitate docking and loading. After loading, the double-conical container is sealed, and then vacuum and heating settings are performed. At the same time, the motor group is started to drive the spherical swivel to swing around the horizontal axis. The initial loading position is the balanced position, and the maximum swing amplitude is controlled at a small The angle of the first cone is equal to or greater than 80°, thereby improving the drying uniformity and efficiency while also reducing the impact on the vacuum nozzle. The scraping and brushing working mode, transition working mode and full rotation working mode are alternately performed at intervals of 3-5 minutes. In the scraping and brushing working mode, the first cone is locked with the spherical rotating body, the first cone is locked with the middle ring, and the second cone is unlocked from the middle ring. At this time, the second cone rotates alone. In the full rotation working mode, the first cone and the second cone are both locked with the middle ring. At this time, it is a double cone. The container realizes overall rotation in the spherical rotator. The temperature of the hot water initially introduced into the jacket heating layer is controlled at 45±5°C, and the vacuum degree is ≤-0.09MPa. At this time, the drying time is controlled at 10±0.5h. The circulating hot water is then heated so that the water temperature in the jacket heating layer is controlled at 60±5°C, and the vacuum degree is ≤-0.09MPa. Drying is continued for 8±1.0h. After the drying is completed, the spherical rotator is rotated so that the material port section is located at the bottom, and the seal is opened for discharging to obtain the dried dapagliflozin drug.

[0019] The beneficial effects of the present invention are as follows: a dryer for the production of dapagliflozin and a drying method thereof are provided by the present invention, wherein the double-conical container of the split module combination and the scraper combination inside the double-conical container can provide a variety of working modes, so that different working modes can be selected according to the drying conditions of the drug, thereby reducing the probability of wall formation during operation, and the wall formation treatment can be completed during operation, and the drying efficiency is also higher. Moreover, since the double-conical container can also simultaneously take into account the rotation around two sets of vertical axis directions during the drying operation, the drying uniformity and drying efficiency can be further improved, and the probability of the occurrence of drying dead corners can be reduced.

[0020] In the present invention, the double-conical container has three working modes. The first working mode is: the first cone and the second cone are both locked with the middle ring, and the double-conical container can realize overall rotation at this time. The second working mode is: when the first cone is locked and connected with the spherical swivel, the first cone is locked with the middle ring and the second cone is disengaged from the middle ring. At this time, the second cone rotates alone, and the first cone is fixed relative to the middle ring and the spherical swivel. The third working mode is: the first cone is locked and connected with the spherical swivel, the second cone is locked with the middle ring and the first cone is disengaged from the middle ring. At this time, the second cone drives the middle ring to rotate, and the first cone is fixed relative to the spherical swivel. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0022] Figure 1 is a structural cross-sectional view of the double-conical container of the present invention when it is at the top;

[0023] Figure 2 yes Figure 1 The structural cross-sectional view when the seal is opened;

[0024] Figure 3 yes Figure 1 Structural diagram when the maximum swing amplitude is equal to 80°;

[0025] Figure 4 It is a partial schematic diagram of the locking part of the middle ring and the first cone and the second cone;

[0026] Figure 5 is a partial schematic diagram of the locking portion of the sealing plate and the first cone;

[0027] Figure 6 yes Figure 1 Sectional view of section AA;

[0028] Markings in the figure:

[0029] 1. Double-cone container; 2. Jacket heating layer; 3. Support layer; 4. Spherical rotating body; 5. Scraper; 6. Mounting frame; 7. Motor set; 8. Liquid passage hole; 9. Horizontal rotating shaft; 11. First cone; 12. Second cone; 13. Middle section ring; 14. Feeding port section; 15. Right-angle slip ring 1; 16. Rotating motor; 17. Right-angle slip ring 2; 18. External rotating ring; 19. Sealing plate; 110. Support seat; 111. Limit ring; 112. First connecting piece; 113. Second connecting piece; 114. Third connecting piece; 1121. Pressure plate; 1122. Guide block; 1123. Plug rod; 1124. Jacking cylinder; 1125. Compression spring; 41. Partition; 42. Sealing cover; 43. Vacuum unit; 44. Pin shaft; 45. Driving cylinder; 46. Sealing ring 1; 47. Sealing ring 2. Detailed implementation mode

[0030] Example 1

[0031] As Figure 1-6 shown, a dryer for the production of dapagliflozin. In this embodiment, it includes a double-cone container 1, a jacket heating layer 2, a support layer 3, and a spherical rotating body 4 arranged in sequence from the inside out. The double-cone container 1 is a split-type modular combination structure and can rotate around its axis. A scraper 5 is arranged inside the double-cone container 1 and fits against the inner wall. When the scraper 5 is disengaged from the locking with the double-cone container 1, the double-cone container 1 rotates, and the scraper 5 rotates and scrapes the inner wall relative to the double-cone container 1. The jacket heating layer 2 is sleeved outside the double-cone container 1 and is used to heat and dry the internal materials through the double-cone container 1. The liquid inlet pipe of the jacket heating layer 2 passes through the support layer 3 and is connected to the liquid inlet cavity of the spherical rotating body 4, and the liquid outlet pipe of the jacket heating layer 2 passes through the support layer 3 and is connected to the liquid outlet cavity of the spherical rotating body 4. The liquid inlet cavity and the liquid outlet cavity of the spherical rotating body 4 are separated by a partition 41, and both ends of the horizontal center of the spherical rotating body 4 are supported on the mounting frame 6 through a horizontal rotating shaft 9. A motor set 7 for driving the rotation of the horizontal rotating shaft 9 is arranged on the mounting frame 6. In the motor set 7, the motor drives the gear to rotate to drive the external gear ring meshing with it and fixed outside the horizontal rotating shaft 9 to rotate, so as to drive the horizontal rotating shaft 9 and the spherical rotating body 4 to rotate. A liquid passage hole 8 is also arranged at the center of the horizontal rotating shaft 9, and the liquid inlet cavity and the liquid outlet cavity are respectively connected to the liquid passage holes 8 at both ends. The liquid passage hole 8 is also connected to the heating storage tank through a rotary joint connected to the end of the horizontal rotating shaft 9, and the heating medium in the heating storage tank circulates through the water pump in the jacket heating layer 2;

[0032] At this point, the split module combination of the double-conical container 1 and the scraper 5 inside it can provide a variety of working modes, so that different working modes can be selected according to the drying conditions of the medicine, so as to reduce the probability of wall formation during work, and can also complete the treatment of wall formation during work, and the drying efficiency is also higher. In addition, since the double-conical container 1 can also take into account the rotation around two sets of axis directions at the same time during the drying work, it can further improve the drying uniformity and drying efficiency, and reduce the probability of drying dead corners.

[0033] The rotation center of the double-conical container 1 is vertically distributed with respect to the rotation center of the spherical rotator 4, so that when the two axes rotate simultaneously, the material inside can achieve a better uniform dispersion effect.

[0034] The double-conical container 1 comprises a first cone 11, a second cone 12 and a middle ring 13 connecting the first cone 11 and the second cone 12, the first cone 11 has a material inlet section 14 at the constricted end, the first cone 11 has a right-angle slip ring 15 installed in the middle ring 13 at the flared end, a rotating motor 16 is externally connected to the center of the constricted end of the second cone 12, the second cone 12 has a right-angle slip ring 2 17 installed in the middle ring 13 at the flared end, the middle ring 13 is installed in the spherical swivel through an external rotating ring 18, and the first cone 11 and the second cone 12 are detachably connected to the middle ring 13, one end of the spherical swivel 4 is provided with a sealing plate 19 for sealing outside the material inlet section 14, and the other end is provided with a support seat 110 for supporting and positioning the rotating motor 16, and at the same time, the first cone 11 and the sealing plate 19 are also detachably connected;

[0035] Therefore, at this time, the double-conical container 1 has three working modes. The first working mode is: the first cone 11 and the second cone 12 are both locked with the middle ring 13, and the double-conical container 1 can realize overall rotation. The second working mode is: when the first cone 11 is locked and connected with the spherical swivel 4, the first cone 11 is locked with the middle ring 13 and the second cone 12 is disengaged from the middle ring 13. At this time, the second cone 12 rotates alone, and the first cone 11 is fixed relative to the middle ring 13 and the spherical swivel 4. The third working mode is: the first cone 11 is locked and connected with the spherical swivel 4, the second cone 12 is locked with the middle ring 13 and the first cone 11 is disengaged from the middle ring 13. At this time, the second cone 12 drives the middle ring 13 to rotate, and the first cone 11 is fixed relative to the spherical swivel 4.

[0036] The scraper 5 is provided with three sections. The first section of the scraper 5 is arranged in contact with the inner wall of the second cone 12, and its two ends are connected to the bottom side of the middle ring 13. The distance between the two ends of the first section of the scraper 5 is the diameter distance of the middle ring 13, that is, the center of the first section of the scraper 5 is colinear with the rotation center of the second cone 12, and the second section of the scraper 5 and the third section of the scraper 5 are connected to the top side of the middle ring 13, and their top ends are in contact with the surface of the first cone 11 and extend to the port of the material mouth section 14.

[0037] The material port section 14 is also provided with a limiting ring 111 for limiting the position of the second and third scraper sections 5 and fitting them on the inner wall of the first cone 11, thereby preventing the second and third scraper sections 5 from tilting inward during use and causing them to separate from the first cone 11.

[0038] The first connecting member 112 for detachably connecting the first cone 11 and the intermediate ring, the second connecting member 113 for detachably connecting the second cone 12 and the intermediate ring, and the third connecting member 114 for detachably connecting the first cone 11 and the spherical swivel 4 are all provided with at least two groups. The first connecting member 112, the second connecting member 113 and the third connecting member 114 have the same structure and all include a pressing plate 1121, a guide block 1122, an insert rod 1123, a pressing cylinder 1124 and a compression spring 1125. The pressing cylinders 1124 of the first connecting member 112 and the second connecting member 113 are installed in the middle The pressing cylinder 1124 of the third connecting member 114 is installed on the sealing plate 19, and the driving end of the pressing cylinder 1124 presses the compression spring 1125 through the pressing plate 1121. The pressing plate 1121 is guided and connected to the guide block 1122, and a plug rod 1123 is fixed thereon for passing through the intermediate ring or the sealing plate 19 and inserted into the right-angle slip ring 15 or the right-angle slip ring 2 17 or the material inlet section 14. One right-angle side of the guide block 1122 is fixedly connected to the middle ring 13 or the sealing plate 19, and the other right-angle side is parallel to the pressing plate 1121 and is used to press the compression spring 1125.

[0039] At this point, when it is necessary to disengage the lock, the pressing cylinder 1124 can be driven to press the pressure plate 1121, so as to drive the insertion rod 1123 to disengage the corresponding first cone 11 or second cone 12. When locking is required, the pressing cylinder 1124 retracts, and the pressure plate 1121 drives the insertion rod 1123 to pass through the intermediate ring or the sealing plate 19 and abut the first cone 11 or the second cone 12 under the pressure of the compression spring 1125. When the first cone 11 or the second cone 12 is rotated into place so that the hole positions are aligned, the insertion rod 1123 is inserted into the corresponding hole position to achieve connection and locking. At this time, if the first cone 11 and the second cone 12 are both in a disengaged locking state relative to the intermediate ring, it is necessary to first complete the locking of the second cone 12 and the intermediate ring, and then perform the locking connection of the first cone 11 and the intermediate ring, and then perform the locking of the first cone 11 and the sealing plate 19.

[0040] The end of the material port section 14 is sealed by a sealing cover 42, and a vacuum pipe port connected to the double-conical container 1 is provided in the sealing cover 42. A vacuum unit 43 for vacuuming is also provided on the sealing cover 42. The vacuum unit 43 adopts a vacuum pump or a centrifugal fan. This structure is a prior art and is not described in detail here. One end of the sealing cover 42 is installed outside the spherical swivel 4 through a pin shaft 44, and a group of driving cylinders 45 are hingedly installed at its end. The other end of the driving cylinder 45 is also hingedly installed outside the spherical swivel 4, and the hinge axis of the driving cylinder 45, the sealing cover 42 and the spherical swivel 4 is parallel to the pin shaft 44. Therefore, the driving cylinder 45 can be started, and the sealing cover 42 can be rotated around the pin shaft 44 to realize the sealing or opening of the material port section 14. When opened, the material port section 14 is used for docking and loading when it is facing upward, and for docking and unloading when it is facing downward.

[0041] A sealing ring 46 for sealing is disposed between the cover 42 and the material inlet section 14 , and a sealing ring 47 for rotating sealing is disposed between the first cone 11 , the second cone 12 and the middle ring 13 .

[0042] The jacket heating layer 2 is divided into two groups of heating units which are respectively arranged outside the first cone 11 and the second cone 12. The heating units are connected to the inner ring of the spherical rotator 4 through the support layer 3, and a sliding surface is also provided on the inner side thereof so that they can slide relative to the first cone 11 and the second cone 12 more smoothly.

[0043] Example 2

[0044] A drying method of a dryer for the production of dapagliflozin, based on a dryer for the production of dapagliflozin in Example 1, comprises the following steps:

[0045] First, the spherical rotator 4 is driven to rotate so that the port of the material inlet section 14 is at the top to facilitate docking and loading. At this time, the centrifugal solid-dapagliflozin semi-finished product rinsed with ethanol is transferred to this double-conical container 1, and the loading amount is controlled at 30%-50% of the volume of the double-conical container 1 to avoid excessive drying, motor overload, and even damage to the vacuum system. During loading, the double-conical container 1 is in a transitional working mode. In this working mode, the second cone 12 is locked with the middle ring 13 and the first cone 11 is unlocked from the middle ring 13, and the rotation is started. The motor 16 is turned on, and the second cone 12 drives the middle ring 13 and the scraper 5 to rotate, while the first cone 11 is fixed relative to the spherical swivel 4. Initially, there is no wall. At this time, the second cone 12 drives the scraper 5 to rotate synchronously to achieve solid shaking during loading and avoid accumulation of falling materials. The first cone 11 is fixed to facilitate docking and loading. After the loading is completed, the double-conical container 1 is sealed, and then vacuuming and heating settings are performed. At the same time, the motor group 7 is started to drive the spherical swivel 4 to swing around the horizontal rotation axis 9. The initial loading position is the equilibrium position, and the maximum swing amplitude is controlled. The angle of the first cone 11 is less than or equal to 80°, so as to improve the drying uniformity and efficiency while also reducing the impact on the vacuum nozzle, and the scraping working mode, transition working mode and full rotation working mode are alternately performed at intervals of 3-5 min. In the scraping working mode, the first cone 11 is locked with the spherical swivel 4, the first cone 11 is locked with the middle ring 13 and the second cone 12 is unlocked from the middle ring 13. At this time, the second cone 12 rotates alone. In the full rotation working mode, the first cone 11 and the second cone 12 are both locked with the middle ring 13. At this time, the double-conical container 1 realizes overall rotation in the spherical rotator 4, and the temperature of the hot water initially introduced into the jacket heating layer 2 is controlled at 45±5°C, and the vacuum degree is ≤-0.09MPa. At this time, the drying time is controlled at 10±0.5h, and then the circulating hot water is heated to make the water temperature in the jacket heating layer 2 controlled at 60±5°C, and the vacuum degree is ≤-0.09MPa. Drying is continued for 8±1.0h, and after drying is completed, the spherical rotator 4 is rotated so that the material port section 14 is located at the bottom, and the seal is opened for discharging to obtain the dried dapagliflozin drug.

[0046] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention is described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A dryer for the production of dapagliflozin, characterized in that: The invention comprises a double-conical container, a jacket heating layer, a support layer and a spherical rotator which are arranged in sequence from the inside to the outside. The double-conical container is a split module combination structure and can rotate around its axis. A scraper arranged in contact with the inner wall is arranged in the double-conical container. When the scraper is separated from the lock with the double-conical container, the double-conical container rotates, and the scraper performs a rotational scraping of the inner wall relative to the double-conical container. The jacket heating layer is sleeved outside the double-conical container and is used to heat and dry the internal material through the double-conical container. The liquid inlet pipe of the jacket heating layer passes through the support layer and is connected to the liquid inlet cavity of the spherical rotator. The liquid outlet pipe of the jacket heating layer passes through the support layer and is connected with the liquid outlet cavity of the spherical rotor. The liquid inlet cavity and the liquid outlet cavity of the spherical rotor are separated by a partition, and the two ends of the horizontal center of the spherical rotor are mounted on the mounting frame through a horizontal rotating shaft. The mounting frame is provided with a motor group for driving the horizontal rotating shaft to rotate. A liquid hole is also provided in the center of the horizontal rotating shaft. The liquid inlet cavity and the liquid outlet cavity are respectively connected with the liquid holes at both ends. The liquid hole is also connected with the heating storage tank through a rotating joint connected to the end of the horizontal rotating shaft, and the heating medium in the heating storage tank is circulated in the jacket heating layer through a water pump.

2. A dryer for producing dapagliflozin according to claim 1, characterized in that: The rotation center of the double-cone container is vertically distributed with respect to the rotation center of the spherical rotator.

3. A dryer for producing dapagliflozin according to claim 1, characterized in that: The double-conical container includes a first cone, a second cone and a middle ring connecting the first cone and the second cone. The first cone is provided with a material mouth section at the necking end, and a right-angle slip ring 1 is provided at the flared end of the first cone, which is installed in the middle ring. A rotating motor is externally connected to the center of the necking end of the second cone, and a right-angle slip ring 2 is provided at the flared end of the second cone, which is installed in the middle ring. The middle ring is installed in the spherical swivel through an external swivel, and the first cone, the second cone and the middle ring are detachably connected. A sealing plate for encapsulating the outside of the material mouth section is provided at one end of the spherical swivel, and a support seat for supporting and positioning the rotating motor is provided at the other end. At the same time, the first cone and the sealing plate are also detachably connected.

4. A dryer for producing dapagliflozin according to claim 3, characterized in that: The scraper is provided with three sections. The first section of the scraper is arranged to fit the inner wall of the second cone, and its two ends are connected to the bottom side of the middle ring. The distance between the two ends of the first section of the scraper is the diameter distance of the middle ring. The second section of the scraper and the third section of the scraper are connected to the top side of the middle ring, and their top ends fit the surface of the first cone and extend to the port of the material mouth section.

5. A dryer for producing dapagliflozin according to claim 4, characterized in that: The material port section is also provided with a limiting ring for limiting the position of the second and third scraper sections to fit on the inner wall of the first cone.

6. A dryer for producing dapagliflozin according to claim 3, characterized in that: The first connecting member for detachably connecting the first cone and the intermediate ring, the second connecting member for detachably connecting the second cone and the intermediate ring, and the third connecting member for detachably connecting the first cone and the spherical swivel are all provided with at least two groups. The first connecting member, the second connecting member and the third connecting member have the same structure and all include a pressure plate, a guide block, an insertion rod, a pressing cylinder and a compression spring. The pressing cylinders of the first connecting member and the second connecting member are installed on the middle ring, and the pressing cylinder of the third connecting member is installed on the sealing plate. The pressing cylinder driving end presses the compression spring through the pressure plate. The pressure plate guide is connected to the guide block, and an insertion rod is fixed thereon for passing through the intermediate ring or the sealing plate and inserted into the right-angle slip ring one or the right-angle slip ring two or the material mouth section. The right-angle side of one end of the guide block is fixedly connected to the middle ring or the sealing plate, and the right-angle side of the other end is parallel to the pressure plate and is used to press the compression spring.

7. A dryer for producing dapagliflozin according to claim 3, characterized in that: The end of the material mouth section is sealed by a sealing cover, and a vacuum pipe mouth connected to the double-conical container is arranged in the sealing cover. A vacuum unit for vacuuming is also arranged on the sealing cover. One end of the sealing cover is installed outside the spherical swivel through a pin shaft, and a group of driving cylinders are hingedly installed at its end. The other end of the driving cylinder is also hingedly installed outside the spherical swivel, and the hinge axis of the driving cylinder, the sealing cover and the spherical swivel is parallel to the pin shaft.

8. A dryer for producing dapagliflozin according to claim 7, characterized in that: A sealing ring 1 for sealing is arranged between the covering end of the sealing cover and the material opening section, and a sealing ring 2 for rotating sealing is arranged between the first cone, the second cone and the middle ring.

9. A dryer for producing dapagliflozin according to claim 3, characterized in that: The jacket heating layer is divided into two groups of heating units which are respectively arranged outside the first cone and the second cone. The heating units are connected to the inner ring of the spherical rotor through a supporting layer, and a sliding surface is also arranged on the inner side thereof.

10. A drying method of a dryer for producing dapagliflozin, based on the dryer for producing dapagliflozin according to any one of claims 3 to 8, characterized in that: The steps include: First, the spherical rotator is driven to rotate so that the port of the material inlet section is at the top to facilitate docking and loading. At this time, the centrifugal solid-dapagliflozin semi-finished product rinsed with ethanol is transferred to this double-conical container, and the loading amount is controlled at 30%-50% of the volume of the double-conical container. During loading, the double-conical container is in a transition working mode. In this working mode, the second cone is locked with the middle ring and the first cone is disengaged from the middle ring. When the rotating motor is started, the second cone drives the middle ring and the scraper to rotate, while the first cone is fixed relative to the spherical rotator. After the loading is completed, the double-conical container is sealed, and then vacuuming and heating are set. At the same time, the motor group is started to drive the spherical rotator to swing around the horizontal axis. The initial loading position is the equilibrium position, and the maximum swing amplitude is controlled to be less than or equal to 80°, and the scraping working mode, transition working mode and full rotation working mode are The formula is alternately performed at intervals of 3-5 min. In the scraping working mode, the first cone is locked with the spherical rotator, the first cone is locked with the middle ring and the second cone is disengaged from the middle ring. At this time, the second cone rotates alone. In the full rotation working mode, the first cone and the second cone are both locked with the middle ring. At this time, the double-conical container realizes overall rotation in the spherical rotator. The initial hot water temperature in the jacket heating layer is controlled at 45±5°C, and the vacuum degree is ≤-0.09MPa. At this time, the drying time is controlled at 10±0.5h, and then the circulating hot water is heated so that the water temperature in the jacket heating layer is controlled at 60±5°C, and the vacuum degree is ≤-0.09MPa. Drying is continued for 8±1.0h. After drying is completed, the spherical rotator is rotated so that the material port section is located at the bottom, and the seal is opened for discharging to obtain the dried dapagliflozin drug.

Images