Drug delivery probe and drug targeted delivery device

Abstract

The invention provides a drug delivery probe and a drug targeted delivery device, and belongs to the technical field of medical instruments. According to the device, the drug delivery probe is navigated to a target position of a vein in a brain by using jugular vein puncture in a minimally invasive surgery mode, so that accurate delivery of drugs is realized. A drug delivery probe includes a probe body, a one-way valve for controlling a one-way flow of a drug, and a securing tip having an automatically unsheathing needle for securing the probe at a target location. The device further comprises a jugular vein puncture assembly, a navigation system and a medicine injection assembly, the navigation system is positioned and navigated through the ventricular radiography auxiliary probe, and the medicine injection assembly injects medicine into a target area through a guide line. The problems that in the prior art, an invasive drug delivery mode causes large damage to a patient, and a non-invasive drug delivery mode is low in drug delivery efficiency are solved, the advantages of being small in wound, accurate in drug delivery, capable of achieving repeated drug delivery and the like are achieved, and a new technical means is provided for drug delivery.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and particularly to a drug delivery probe and a drug targeted delivery device. Background Art

[0002] Currently, there are various intervention methods for nervous system-related problems, such as surgery, physical intervention, alternative therapies, etc. However, these methods still have limitations in some cases. For example, for the management of some complex conditions (such as primary brain tumors), there is a lack of effective relief means. Therefore, it is particularly important to develop technologies that can efficiently deliver drugs.

[0003] The blood-brain barrier (BBB) is composed of brain microvascular endothelial cells, astrocytes, pericytes, and the basement membrane. Among them, the blood-brain barrier at the level of brain microvascular endothelial cells is the main site for the exchange between blood and the central nervous system. There are complex tight junctions between adjacent vascular endothelial cells, which can effectively limit paracellular permeability. These cells and tight junctions can prevent harmful substances from crossing the blood-brain barrier, maintain the stability of the brain's internal environment, and protect the brain from neurotoxic compounds. However, at the same time, they also limit the entry of hydrophilic drugs and macromolecules (such as polypeptides) into the central nervous system to exert pharmacological effects. In addition, the blood-brain barrier also has a metabolic barrier function, pumping some drugs back into the blood circulation through efflux transporters, resulting in a decrease in the drug concentration in the brain, which poses a challenge to drug delivery.

[0004] Based on the above problems, the currently common drug delivery methods are mainly divided into two types: invasive and non-invasive. Invasive delivery techniques include direct intracerebral injection and intrathecal delivery, etc. These methods can effectively bypass the blood-brain barrier and enable the drug to act directly on the target site. However, these methods have potential safety problems. For example, nerve tissue may be damaged during the surgical process, or central nervous system toxicity may be caused, causing secondary harm to the patient. Non-invasive delivery methods include drug carriers and efflux pump inhibitors, etc., which can avoid the risks brought by invasive surgery and cross the blood-brain barrier to a certain extent. However, in different situations, the opening degree and leakage gaps of the blood-brain barrier vary, so selecting a suitable drug delivery carrier is an urgent problem to be solved. Summary of the Invention

[0005] The purpose of the present invention is to provide a drug delivery probe and a drug targeted delivery device, which solve the problems in the prior art that invasive drug delivery methods cause greater damage to patients and non-invasive drug delivery methods have low drug delivery efficiency, and have the advantages of small trauma, precise drug delivery, and repeatable drug administration, providing a new technical means for drug delivery.

[0006] To achieve the above purpose, the present invention provides a drug delivery probe, comprising:

[0007] A probe body for navigating to a lesion location in vivo;

[0008] A one-way valve is provided on the probe body for controlling the one-way flow of the drug;

[0009] A fixed tip for fixing the probe body after reaching the lesion.

[0010] Preferably, the one-way valve opens when the drug is injected.

[0011] Preferably, the probe body is a 20G puncture needle.

[0012] Preferably, the fixed tip includes a protective sheath and a fixed anchor point. Among them, the fixed anchor point has a symmetrical two-sided structure, with a length of 4.5 - 5 mm and a width of 1.5 mm; the length, width and height of the protective sheath are 1 mm × 1 mm × 1.5 mm, and it is used to wrap the 20G puncture needle. The 20G puncture needle is independently arranged from the probe body and has a diameter of 0.91 mm.

[0013] The present invention also provides a drug targeted delivery device, including the drug delivery probe as described above. The drug targeted delivery device further includes:

[0014] A jugular vein puncture assembly for puncturing a patient's jugular vein and establishing a drug delivery pathway;

[0015] A navigation system for positioning and navigating the drug delivery probe with the assistance of ventriculography;

[0016] An injection assembly for injecting the drug into the lesion through the drug delivery probe.

[0017] Preferably, the jugular vein puncture assembly includes a puncture kit, a disinfection kit, a single-lumen, double-lumen or triple-lumen central venous catheter, a heparin cap, povidone iodine, a syringe, and lidocaine local anesthetic.

[0018] Preferably, the navigation system navigates the drug delivery probe by means of ventriculography.

[0019] Preferably, the drug assembly injects the drug into the drug delivery probe through a guide wire.

[0020] Therefore, the present invention adopts the above-mentioned drug delivery probe and drug targeted delivery device, and the beneficial technical effects are as follows:

[0021] Compared with existing drug delivery methods, the targeted drug delivery device achieved through minimally invasive surgery proposed by the present invention has significant technical advantages. First, compared with traditional invasive drug delivery methods (such as craniotomy, etc.), the minimally invasive surgery method adopted by the present invention can significantly reduce the damage to brain tissue and avoid secondary injuries that may be caused by highly invasive techniques. In addition, the device of the present invention can effectively fix the drug delivery probe and support repeated drug administration, solving the problem that it is difficult to achieve repeated drug administration with traditional invasive drug delivery methods.

[0022] At the same time, compared with non-invasive drug delivery methods, the device of the present invention can effectively reduce the loss of drugs during the process of crossing the blood-brain barrier, enabling the drugs to reach the target area more efficiently and accurately. Through a precise navigation system and an optimized delivery path, the device of the present invention significantly improves the efficiency and accuracy of drug delivery, providing a more efficient and reliable solution for drug delivery. Brief Description of the Drawings

[0023] Figure 1 It is a schematic structural diagram of the drug delivery probe of the present invention;

[0024] Figure 2 It is a schematic structural diagram of the fixed tip;

[0025] Figure 3 It is a jugular vein puncture diagram;

[0026] Figure 4 It is a navigation route diagram of the drug delivery probe.

[0027] Reference Signs in the Drawings

[0028] 1, one-way valve; 2, probe body; 3, fixed tip; 301, protective sleeve; 302, fixed anchor point. Detailed Embodiments

[0029] The technical solution of the present invention will be further described below with reference to the drawings and embodiments.

[0030] Unless otherwise defined, the technical terms or scientific terms used in the present invention shall have the ordinary meanings understood by those of ordinary skill in the art to which the present invention pertains.

[0031] Embodiment 1

[0032] The present invention provides a drug delivery probe and a drug targeted delivery device for achieving precise drug delivery. The device uses jugular vein puncture through minimally invasive surgery to navigate the drug delivery probe to the target position of the internal cerebral vein, ensuring that the drug can reach the target area efficiently and precisely.

[0033] 1. Design of the drug delivery probe (The overall length of the drug delivery probe is 30 mm.).

[0034] As Figure 1 shown, the drug delivery probe includes the following main parts:

[0035] Probe body 2: Used to navigate to the target position in the body. The probe body 2 is designed to be able to navigate through the jugular vein, straight sinus, great cerebral vein, and internal cerebral vein.

[0036] One-way valve 1: Set on the probe body 2 to control the unidirectional flow of drugs. When the drug is injected through the guiding tube, the one-way valve 1 opens to ensure the smooth flow of the drug to the target area; when there is no pressure, the one-way valve 1 closes to prevent liquid backflow.

[0037] Fixing tip 3: Used to fix the probe body 2 after reaching the target position. The fixing tip 3 has a 20G needle that can automatically sheath out. It can automatically sheath out and fix the probe body 2 after reaching the target position to ensure the stability of the probe at the target position.

[0038] As Figure 2 shown, the fixing tip 3 is mainly composed of a protective sleeve 301 and a fixing anchor 302. The overall device is made of PVP material, which can effectively improve the compatibility of the device with human tissues, reduce the body's rejection reaction to the device, and lower the risk of inflammation and infection. At the same time, the device is designed as a smooth tubular body, which can promote the maintenance of venous blood flow around the device and minimize the risk of thrombus formation.

[0039] The fixing anchor 302 is designed to be about 4.5 - 5 mm long. Since there are many blood vessels and nerve function-related structures in the brain, to ensure the safety of the patient, the maximum puncture distance cannot exceed 5 mm. At the same time, to ensure that the fixing anchor 302 can be fully deployed, the length of the fixing anchor 302 cannot be too short. At the same time, the fixing anchor 302 is symmetric on both sides, and one side is about 1.5 mm wide, which can effectively fix and prevent damage to blood vessels and nerves to the greatest extent.

[0040] The length, width, and height of the protective sleeve 301 are 1 mm × 1 mm × 1.5 mm, and the diameter of the 20G needle is 0.91 mm, which can completely cover and wrap the 20G needle to protect the safety of the patient.

[0041] When navigating to a specific position, the probe penetrates into the target position, and the fixing tip 3 will gradually compress with the obstruction of the blood vessel. As the probe reaches the other side of the target. When the probe completely reaches the designated position, the fixing anchors 302 on both sides unfold and block on the blood vessel wall, thus effectively fixing the device. At the same time, the protective sleeve wraps the needle to achieve the protection of other body parts.

[0042] 2. Composition of the drug targeting delivery device.

[0043] The drug targeting delivery device includes the following components:

[0044] Jugular vein puncture component: used to puncture the patient's jugular vein and establish a drug delivery pathway. The puncture component includes a puncture kit, a disinfection kit, a single-lumen / double-lumen / triple-lumen central venous catheter, a heparin cap, povidone iodine, a syringe, and lidocaine local anesthetic.

[0045] Navigation system: used to position and navigate the drug delivery probe with the assistance of ventriculography. By injecting contrast agent to obtain blood vessel images and formulating a navigation path in combination with the image processing unit, it ensures that the probe can accurately reach the target position.

[0046] Drug injection component: used to inject drugs into the target area through the drug delivery probe. The drug injection component includes a guiding tube and a syringe. The guiding tube is connected to the drug delivery probe, and the syringe is used to inject drugs into the guiding tube.

[0047] 3. Drug delivery process.

[0048] Jugular vein puncture.

[0049] As Figure 3 shown, a puncture operation is performed at the patient's jugular vein to establish a drug delivery pathway. Before puncture, prepare a puncture kit, a disinfection kit, a single-lumen / double-lumen / triple-lumen central venous catheter, a heparin cap, povidone iodine, a syringe, and lidocaine local anesthetic. The patient lies in the supine position, with a small pillow under the shoulder on the puncture side, the shoulder hyperextended, the head tilted back 20° - 30°, and the head turned to the opposite side. The puncture site is usually selected at the midpoint or slightly above the anterior border of the sternocleidomastoid muscle. The needle shaft forms an angle of 30° with the skin for puncture. When there is a breakthrough sensation and blood is aspirated, it indicates successful blood vessel puncture.

[0050] Probe navigation and deployment.

[0051] After local anesthesia of the patient, find the jugular vein and inject 50 IU / kg of heparin to inhibit the activation of prothrombin. Inject contrast agent to obtain blood vessel images and formulate a navigation plan in combination with the image processing unit. As Figure 4 shown, insert the guiding needle connected to the drug delivery probe into the jugular vein along the navigation path, retrograde to the confluence of sinuses, continue to ascend along the straight sinus direction to the great cerebral vein, and finally enter the internal cerebral vein. After determining the fixed position of the probe according to the target position, the needle at the tip automatically sheaths and fixes the probe.

[0052] Drug injection.

[0053] Inject drugs into the target area through the drug injection component. The drugs enter the drug delivery probe through the guiding tube. When the pressure increases, the one-way valve 1 on the probe opens, and the drugs smoothly flow to the target area, achieving precise drug delivery.

[0054] Therefore, by adopting the above-mentioned drug delivery probe and drug targeted delivery device, the present invention solves the problems of great damage to patients caused by invasive drug delivery methods and low drug delivery efficiency of non-invasive drug delivery methods in the prior art, and has the advantages of small trauma, precise drug delivery, repeatable drug administration, etc., providing a new technical means for drug delivery.

[0055] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit them. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that they can still modify or equivalently replace the technical solutions of the present invention, and these modifications or equivalent replacements cannot make the modified technical solutions deviate from the spirit and scope of the technical solutions of the present invention.

Claims

1. A drug delivery probe, characterized in that: include: A probe body, used for navigating to the lesion location in the body; a one-way valve, disposed on the probe body, for controlling the one-way flow of the drug; The fixing tip is used to fix the probe body after reaching the lesion.

2. A drug delivery probe according to claim 1, characterized in that: The one-way valve opens when the drug is injected.

3. A drug delivery probe according to claim 1, characterized in that: The fixed tip has a 20G puncture needle.

4. A drug delivery probe according to claim 1, characterized in that: The fixed tip includes a protective cover and a fixed anchor point, wherein the fixed anchor point is a symmetrical two-sided structure with a length of 4.5-5mm and a width of 1.5mm; the length, width and height of the protective cover are 1mm×1mm×1.5mm, and are used to wrap a 20G puncture needle. The 20G puncture needle is independently arranged from the probe body, and its diameter is 0.91mm.

5. A drug targeted delivery device, comprising the drug delivery probe according to claim 1, characterized in that: The drug targeted delivery device further comprises: A jugular vein puncture kit is used to puncture the patient's jugular vein and establish a drug delivery channel; a navigation system for positioning and navigating the drug delivery probe with the assistance of ventriculography; The drug injection component is used to inject the drug into the lesion through the drug delivery probe.

6. A drug targeted delivery device according to claim 5, characterized in that: The jugular vein puncture assembly comprises a puncture bag, a disinfection bag, a single-lumen, double-lumen or triple-lumen deep vein catheter, a heparin cap, iodine tincture, a syringe, and lidocaine local anesthetic.

7. A drug targeted delivery device according to claim 5, characterized in that: The navigation system navigates the drug delivery probe by means of ventriculography.

8. A drug targeted delivery device according to claim 5, characterized in that: The drug component injects the drug into the drug delivery probe through the guide wire.

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