Traditional Chinese medicine formula for treating cough caused by mycoplasma pneumoniae infection

Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine formula for treating cough caused by mycoplasma pneumoniae infection, which comprises the following raw materials in parts by weight: 10g of ephedra, 10g of semen armeniacae amarae, 10g of platycodon grandiflorum, 10g of liquorice, 10g of fructus perillae, 10g of rhizoma pinellinae praeparata, 10g of mangnolia officinalis, 10g of poria cocos, 10g of scutellaria baicalensis, 10g of lumbricus, 10g of inula flower (decocted in a wrapped manner), 15g of uncaria (decocted later) and 5g of ginger. Based on the theory of traditional Chinese medicine, aiming at the key pathogenesis of wind-heat affecting lung and lung dysfunction (lung qi is mainly not lowered), the traditional Chinese medicine components are matched with one another, so that frequent irritant cough is quickly relieved, the course of cough is shortened, and a patient gets rid of cough trouble as soon as possible. The traditional Chinese medicine prescription does not depend on an antibiotic action mechanism, provides a brand new and effective medication selection for clinical treatment, and fills the blank of a targeted traditional Chinese medicine prescription for treating cough caused by mycoplasma pneumonia infection. And a new hope and a new choice are brought to a patient who is deeply suffered from cough impairment caused by mycoplasma pneumoniae infection.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine formula for treating cough caused by mycoplasma pneumoniae infection. Background Art

[0002] Mycoplasma pneumoniae (MP) is one of the common pathogens that cause respiratory tract infections, especially in children and adolescents, with a high incidence rate. In recent years, MP infection has shown a cyclical epidemic trend, and the number of people affected by it continues to rise worldwide.

[0003] After Mycoplasma pneumoniae infects the human body, the respiratory mucosa will be invaded first, which will trigger a series of immune responses. Cough and fever are the main clinical manifestations of Mycoplasma pneumoniae infection. Among them, the cough symptoms are extremely prominent and stubborn. The incidence of cough is 80%-100%. In the early stage of the disease, dry cough is the main symptom. In mild cases, it is intermittent dry cough. In severe cases, it is a violent, frequent, irritating cough, and may be a whooping cough. In the later stage, it may be accompanied by white or yellow sputum, and some may experience wheezing. The cough caused by Mycoplasma pneumoniae often has a long course and can last for several weeks, which brings great trouble to the patient's daily life and significantly reduces the quality of life.

[0004] For Mycoplasma pneumoniae infection, current Western medical treatment includes anti-infection treatment and symptomatic treatment. The first choice for anti-infection treatment is macrolide antibiotics (such as azithromycin and roxithromycin), followed by quinolones (such as levofloxacin, gatifloxacin, moxifloxacin) or tetracycline antibiotics (such as tetracycline and doxycycline). The course of treatment is generally 2-3 weeks. In terms of symptomatic treatment, if sputum is difficult to cough up, expectorants such as ambroxol hydrochloride, bromhexine, and myrtle oil extract can be used; antitussive drugs (such as pentoxyverine and dextromethorphan) can be used for severe dry cough.

[0005] However, with the widespread use of antibiotics, the problem of drug resistance of Mycoplasma pneumoniae has become increasingly prominent. Several studies have shown that the resistance rate of Mycoplasma pneumoniae to traditional macrolide antibiotics in some areas has exceeded 30%, which greatly reduces the treatment effect.

[0006] In addition, drug side effects are also an issue that cannot be ignored. The side effects of macrolide antibiotics include gastrointestinal reactions, liver damage, cardiac toxicity, ototoxicity, and allergic reactions, among which gastrointestinal reactions are common. Because fluoroquinolones have an inhibitory effect on the growth of cartilage tissue, they are not recommended for use in people under 18 years of age. Tetracycline antibiotics also have many side effects. In addition to common gastrointestinal reactions, there is also the possibility of liver damage. In addition, tetracycline can also cause "tetracycline teeth" in children, so tetracycline antibiotics are also used with caution in children and only as a secondary drug.

[0007] In clinical practice, even if many patients use Western medicine in a standardized manner, their cough still persists and eventually becomes a chronic cough with a poor prognosis.

[0008] In summary, whether based on clinical efficacy or out of consideration for special drug users (children, patients with drug allergies or obvious adverse drug reactions), a safer and more effective treatment method is urgently needed.

[0009] Traditional Chinese medicine is a medical technology that has been clinically practiced for thousands of years. With more and more modern medical research discoveries and confirmations, traditional Chinese medicine has gradually been re-emphasized and recognized. However, at this stage, there is still a lack of research results specifically targeting cough caused by Mycoplasma pneumoniae infection. The existing formulas for treating cough have deficiencies in efficacy and repeatability, etc., and it is difficult to meet the urgent clinical needs. Summary of the invention

[0010] The object of the present invention is to provide a Chinese medicine formula for treating cough caused by Mycoplasma pneumoniae infection, so as to solve the problems raised in the above background technology.

[0011] To achieve the above object, the present invention provides the following technical solutions:

[0012] A Chinese medicine formula for treating cough caused by mycoplasma pneumonia infection, comprising the following raw materials in parts by weight: 10 grams of ephedra, 10 grams of bitter almond, 10 grams of platycodon, 10 grams of liquorice, 10 grams of perilla seed, 10 grams of pinellia, 10 grams of magnolia bark, 10 grams of tuckahoe, 10 grams of scutellaria, 10 grams of earthworm, 10 grams of inula flower (wrapped and decocted), 15 grams of Uncaria rhynchophylla (added later), and 5 grams of ginger.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] This formula has been shown to have significant efficacy in repeated clinical practice for the treatment of cough caused by Mycoplasma pneumoniae infection. Whether used alone or in combination with Western antibiotics, it can significantly shorten the course of the disease and quickly stop coughing. With timely treatment and in the absence of other complications, coughing can generally be significantly relieved after 3 doses, and recovery can be achieved in about a week.

[0015] This formula is also very friendly in terms of safety. It can be used by adults and children (reduced dosage based on weight and age), and clinical adverse reactions are extremely rare.

[0016] This Chinese medicine formula does not rely on the mechanism of action of antibiotics, and provides a new and effective medication option for clinical treatment, filling the gap in targeted Chinese medicine prescriptions for treating cough caused by Mycoplasma pneumoniae infection. It brings new hope and new options to patients who are deeply tormented by cough caused by Mycoplasma pneumoniae infection. DETAILED DESCRIPTION

[0017] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] The present invention provides a Chinese medicine formula for treating cough caused by Mycoplasma pneumoniae infection:

[0019] Applicable conditions: Meet the following ①+②+③ situations.

[0020] ①Clinical manifestations: Cough, which is caused by itchy throat or qi reversal, mainly dry cough, with a small amount of sputum, mostly white or yellow sputum, not much, not easy to cough up, and frequent coughs in severe cases, irritating and choking coughs, and severe degree. The tongue is light red or slightly red, with a thin white or thin yellow coating, and a floating pulse.

[0021] ② Auxiliary examination: Mycoplasma pneumoniae antibody IgM is positive. Or the titer of Mycoplasma pneumoniae antibody IgM is ≥1:160. Or the titer of Mycoplasma pneumoniae antibody IgM or IgG in double serum samples during the recovery period and acute period increases or decreases by 4 times or more.

[0022] ③ Western medicine diagnosis: Mycoplasma pneumoniae infection

[0023] TCM diagnosis: Cough (mainly caused by wind-heat invading the lungs, the lungs failing to descend, and the lung qi failing to descend)

[0024] Dosage: This prescription is generally for people weighing 40-80 kg. People weighing less than 40 kg or more than 80 kg can also refer to the weight / 60 ratio of this prescription. For children under 6 months old, 1 / 10 of this prescription is generally used; for children over 6 months old to under 2 years old, 1 / 5 of this prescription is generally used.

[0025] Directions:

[0026] Traditional Chinese medicine: One dose per day, divide the decoction into 2 equal portions and take half an hour after meals during the day and at night. Best taken warm.

[0027] Granules: One dose per day, dissolve in boiling water, divide into 2 equal portions, and take half an hour after meals during the day or at night. It is best to take it warm.

[0028] Treatment course: 3-7 days of continuous use as a course of treatment. During the medication period, patients need to maintain a light diet, avoid beef, chicken, dog meat, Muscovy duck, goose meat, avoid raw, cold, greasy, spicy and irritating food, quit smoking and drinking, and pay attention to rest and avoid overwork.

[0029] Contraindications: Patients with acute myocardial infarction, acute cerebral hemorrhage or bleeding in important organs, tachycardia, glaucoma, malignant hypertension, hypertensive encephalopathy, and hypertensive crisis should not use this product. Patients with hyperthyroidism, prostatic hypertrophy, and pregnant women should use it with caution.

[0030] Embodiment 1:

[0031] A Chinese medicine formula for treating cough caused by Mycoplasma pneumoniae infection:

[0032] The prescription includes the following raw materials in parts by weight: 10 grams of ephedra (small package), 10 grams of bitter almond (small package), 10 grams of platycodon (small package), 10 grams of licorice (small package), 10 grams of perilla seed (small package), 10 grams of pinellia (small package), 10 grams of magnolia bark (small package), 10 grams of poria (small package), 10 grams of earthworm (small package), 10 grams of scutellaria baicalensis (small package), 10 grams of inula flower (small package) (decoction), 15 grams of Uncaria rhynchophylla (small package) (added later), and 5 grams of ginger.

[0033] Preparation method:

[0034] Take out and prepare:

[0035] Take out ephedra (10 grams), bitter almond (10 grams), platycodon (10 grams), licorice (10 grams), perilla seed (10 grams), pinellia (10 grams), magnolia bark (10 grams), poria (10 grams), earthworm (10 grams), scutellaria baicalensis (10 grams), inula flower (10 grams), and Uncaria rhynchophylla (15 grams) from the small package.

[0036] Put 10g of the decocted Inula flower into a cotton decoction bag, and tighten the rope on the non-woven decoction bag to prevent the Inula flower from leaking out of the decoction bag. Put 15g of Uncaria rhynchophylla in a small bowl. Slice 5g of ginger and set aside for later use.

[0037] soak:

[0038] Put all processed herbs except Uncaria rhynchophylla into a casserole or ceramic decoction pot, add 600ml of water, and soak for 30 minutes to allow the herbs to fully absorb water and facilitate the extraction of effective ingredients. Then add 100ml of water to a small bowl containing 15g of Uncaria rhynchophylla and soak.

[0039] First cooking:

[0040] First, use high heat to quickly heat the soaked herbs and their soaking liquid in the decoction pot until boiling, then turn to low heat, maintain a slight boiling state, and stir gently with a ceramic spoon from time to time to allow the herbs to be heated evenly to prevent local scorching. After 20 minutes of low heat, add 15 grams of the soaked Uncaria rhynchophylla and its soaking liquid into the pot, boil over high heat, then turn to low heat, and turn off the heat after decocting for 5 minutes. Use clean gauze to filter the liquid into a clean container. When the temperature of the residue drops to a level that is not too hot, squeeze the residue in the gauze to fully squeeze out the remaining liquid and collect it in the above clean container.

[0041] Secondary decoction:

[0042] Add 300 ml of clean water to the residue after filtering and squeezing, boil over high heat, then simmer over low heat, and turn off the heat after 20 minutes of boiling. Filter the liquid medicine again, squeeze the residue, and collect the liquid medicine, following the same process as the first decoction.

[0043] Combined solution:

[0044] After the second decoction is completed, combine the two decoctions into the same clean container, stir evenly and divide into 2 equal portions for later use. Take it half an hour after meals during the day and at night.

[0045] Embodiment 2:

[0046] A Chinese medicine formula for treating cough caused by Mycoplasma pneumoniae infection:

[0047] The prescription includes the following raw materials in parts by weight: 10 grams of ephedra (granule granule), 10 grams of bitter almond (granule granule), 10 grams of platycodon (granule granule), 10 grams of liquorice (granule granule), 10 grams of perilla seed (granule granule), 10 grams of pinellia (granule granule), 10 grams of magnolia bark (granule granule), 10 grams of poria (granule granule), 10 grams of earthworm (granule granule), 10 grams of scutellaria baicalensis (granule granule), 10 grams of inula flower (granule granule), 15 grams of Uncaria rhynchophylla (granule granule), and 5 grams of ginger (granule granule).

[0048] Preparation method:

[0049] Cut open the packaging bags of 10 grams of ephedra (granules), 10 grams of bitter almond (granules), 10 grams of platycodon (granules), 10 grams of licorice (granules), 10 grams of perilla seed (granules), 10 grams of pinellia (granules), 10 grams of magnolia bark (granules), 10 grams of poria (granules), 10 grams of earthworm (granules), 10 grams of scutellaria (granules), 10 grams of inula flower (granules), 15 grams of Uncaria rhynchophylla (granules), 5 grams of ginger (granules), etc., pour all the above granules into the same bowl, add 300 ml of boiling water, stir thoroughly with a ceramic or stainless steel spoon, wait for the granules to dissolve, divide into 2 equal portions, and take half an hour after meals during the day and at night.

[0050] It is worth noting that the ephedra in the formula of the present invention includes but is not limited to honey ephedra, and the licorice includes but is not limited to roasted licorice, which can be selected based on the existing varieties of ephedra and licorice.

[0051] Meanwhile, the prescription of the present invention is an improvement and expansion based on Huanhun decoction and Banxiahoupu decoction.

[0052] Huanhun Decoction was first mentioned in Zhang Zhongjing's Synopsis of the Golden Chamber. Three liang of ephedra (without the nodes), seventy almonds (without the skin and tips), and one liang of licorice (roasted). Add the above three ingredients to eight liters of water, boil until three liters are left, remove the dregs, and swallow the mixture in portions. It can cure all kinds of infections.

[0053] Later generations improved the Hunhun Decoction into "Sanao Decoction", which is composed of ephedra, apricot kernel, and licorice. It was later included in Volume 2 of "Taiping Huimin Hejijufang". "Ao" means to go against the rules. "Sanao" means that the three medicines used are all used in violation of the usual method. Ephedra is not removed from the root nodes, apricot kernel is not removed from the skin and tip, and licorice is not roasted but used raw. It goes against the ancient method, so it is named "Sanao Decoction", mainly for its sweating and asthma-relieving effects. Sanao Decoction is good at promoting lung function and relieving symptoms, and is mainly used to treat exogenous wind and cold, and lung qi is not promoted. Symptoms include nasal congestion, heavy voice, inability to speak, or cold, headache and dizziness, stiff limbs, cough with sputum, chest tightness, shortness of breath, no sweat, no thirst, white tongue coating, and floating pulse.

[0054] Banxia Houpu Decoction was first mentioned in Zhang Zhongjing's Synopsis of the Golden Chamber. It is made up of pinellia, magnolia bark, poria, ginger, and perilla leaves. It is boiled in water and taken after consumption. It has the effects of promoting qi and dispersing stagnation, lowering adverse qi and resolving phlegm. Later generations of doctors often replaced perilla leaves with perilla seeds to treat coughs caused by lung qi failure.

[0055] The cough caused by Mycoplasma pneumoniae infection is more severe than ordinary cough, has a longer natural course, and is more difficult to treat. A large number of clinical practices have found that the effect of Sanao Decoction combined with Banxia Houpu Decoction is not obvious. Other types of formulas have been tried, but the effect is not good.

[0056] From the observation of a large number of clinical patients with cough caused by Mycoplasma pneumoniae infection, it was found that the clinical pathogenesis of cough caused by Mycoplasma pneumoniae infection is that wind-heat invades the lungs and the lungs fail to descend (mainly due to the failure of lung qi to descend). The treatment principle should be to promote lung qi and stop cough, and to reduce adverse reactions and relieve asthma. Therefore, this prescription adds Platycodon grandiflorum to the Huanhun Decoction and Banxia Houpu Decoction to enhance the effect of promoting lung qi, and adds Inula flower, Uncaria rhynchophylla, and Pheretima to strengthen the descending of lung qi. Because the cough is mainly caused by the failure of lung qi to descend, a variety of Qi-reducing and cough-relieving drugs such as Perilla seed, Pinellia tuber, Magnolia bark, Inula flower, Uncaria rhynchophylla, and Pheretima are used in the prescription. Through the combination of drugs with different descending mechanisms, the purpose of reducing qi, relieving asthma and stopping cough is finally achieved. In addition, due to exogenous wind-heat, Scutellaria baicalensis is added to the prescription to clear the lungs and purge fire, preventing cough caused by the reverse of lung fire. Poria strengthens the spleen and eliminates dampness, eliminating the source of phlegm.

[0057] The efficacy of the drug composition of the present invention is analyzed as follows:

[0058] Ephedra: pungent, slightly bitter, warm, enters the lung and bladder meridians. It has the effects of sweating and relieving exterior symptoms, promoting lung function and relieving asthma, and promoting diuresis and reducing swelling. Among them, sweating and relieving exterior symptoms should be used raw, while cough and asthma should be relieved by roasting. The "Shennong Bencao Jing" records the effect of "relieving cough and reverse breathing". In the formula, ephedra can strongly open and promote lung qi, so that the lung qi can be unblocked, dispel external evil, and create basic conditions for relieving cough. Modern pharmacological studies have confirmed that the active ingredients ephedrine and pseudoephedrine both have the effect of relieving bronchial smooth muscle spasms. Ephedra decoction has anti-allergic, anti-inflammatory and antitussive effects.

[0059] Bitter almond: bitter, slightly warm, slightly toxic, belongs to the lung and large intestine meridians. It has the effects of descending qi, relieving cough and asthma, and moistening the intestines and relieving constipation. "Zhenzhu Nang Yaoxing Fu" records that it has the effects of "removing lung heat, treating wind dryness in the upper part of the body, benefiting chest and diaphragm qi reversal, and moistening the large intestine qi constipation". This product has a bitter taste and descends, and it can descend and relieve cough. When used with ephedra, ephedra promotes lung qi, and bitter almonds reduce qi and relieve cough. One promotes and one reduces, restoring the normal function of the lungs to promote and descend, and synergistically enhancing the effect of relieving cough and asthma. At the same time, bitter almonds also have the effect of promoting lungs, resolving the symptoms of frequent coughs and qi reversal. Modern pharmacological studies have shown that after oral administration of the active ingredient amygdalin, a small amount of hydrocyanic acid is produced after decomposition in the lower digestive tract, which can inhibit the cough center and have an antitussive and anti-asthmatic effect. It also has obvious analgesic and anti-inflammatory effects.

[0060] Platycodon grandiflorum: bitter, pungent, neutral, belongs to the lung meridian. It has the effects of clearing the lungs, relieving sore throat, removing phlegm, and draining pus. "The Medicinal Properties of Pearl Capsule" records that "it has four uses: relieve sore throat and remove nasal congestion; relieve diaphragmatic qi and treat lung abscess; one is the boat of all medicines; the other is the guide of the lungs". Its lung clearing power helps to dispel the evil qi in the lungs and assists in improving the lung clearing, cough relieving and phlegm removing effects of the entire formula. Modern pharmacological studies have shown that Platycodon grandiflorum has the effects of diluting sputum, relieving cough, enhancing anti-inflammatory and immune effects, enhancing the phagocytic function of macrophages, enhancing the bactericidal power of neutrophils, and increasing the activity of lysozyme.

[0061] Roasted or raw licorice: sweet, flat, and enters the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, removing phlegm and relieving cough, relieving pain, clearing away heat and detoxifying, and harmonizing various medicines. Raw licorice is slightly cold in nature and can clear away heat and detoxify; roasted licorice is slightly warm in nature and can enhance the effects of tonifying the heart and spleen qi and moistening the lungs and relieving cough. "Famous Doctors' Records" records that it "warms the middle and lowers the qi, relieves fullness and shortness of breath, and coughs caused by damaged organs." "Compendium of Materia Medica" records that it "harmony and replenishes qi. It is also a medicine for tonifying deficiency and detoxification." In this prescription, it relieves cough, resolves phlegm, alleviates the harshness of other medicinal materials, reduces stimulation to the body, and at the same time tonifies the spleen and lungs, helping to restore positive energy. Modern medical pharmacology research shows that licorice has antitussive, expectorant, antiasthmatic, antibacterial, antiviral, anti-inflammatory and anti-allergic effects.

[0062] Perilla seed: pungent, warm, enters the lung and large intestine meridians. It has the effects of descending qi and resolving phlegm, relieving cough and asthma, and moistening the intestines and relieving constipation. "Ben Jing Feng Yuan" records: "It has the effect of descending qi, so it is suitable for people with chest and diaphragm discomfort... It is a good medicine for eliminating asthma and cough, eliminating phlegm and relieving qi." This product is mainly descending in nature, good at descending lung qi and resolving phlegm. For the upward reversal of lung qi caused by Mycoplasma pneumoniae infection, perilla seed can guide the lung qi downward, resolve phlegm and relieve asthma, and promote the discharge of phlegm. Modern pharmacological studies have shown that perilla seed flavonoids have the effect of relaxing bronchial smooth muscle spasms and relieving asthma. In addition, it has antibacterial, antifungal and antioxidant effects.

[0063] Pinellia: pungent, warm, toxic, belonging to the lung, spleen, and stomach meridians. It has the effects of drying dampness and resolving phlegm, lowering adverse reactions and stopping vomiting, and eliminating lumps and dispersing lumps. Among them, because the French Pinellia is good at drying dampness and has a weaker warm property, this prescription uses the French Pinellia. "Famous Doctors' Records" records that "it can eliminate phlegm and heat in the heart, abdomen, chest and diaphragm, and cough and shortness of breath." This product is pungent and warm. Its drying power can dissolve phlegm and dampness in the lungs, making the airway more refreshing, and its lowering adverse reaction also strengthens the lung qi descending function, while also alleviating nausea, vomiting and other discomforts caused by coughing. Modern pharmacological studies have confirmed that the French Pinellia has a significant expectorant and antitussive effect.

[0064] Magnolia officinalis: bitter, pungent, warm, enters the spleen, stomach, lung, and large intestine meridians. It has the effects of drying dampness and eliminating phlegm, and removing qi and fullness. "Famous Doctors' Records" records that it "mainly eliminates phlegm and removes qi". In the formula, it plays a synergistic role with Pinellia ternata to enhance the effect of drying dampness and eliminating phlegm, while descending lung qi and reducing cough caused by lung qi failure. Modern pharmacological studies have shown that Magnolia officinalis enhances cellular immunity. The active ingredient magnolol has anti-inflammatory effects and can reduce the permeability of capillaries in the inflamed area. In addition, it has antibacterial, antifungal, antiviral and anticancer effects.

[0065] Poria: sweet, light, flat, and enters the heart, spleen, and kidney meridians. It has the effects of diuresis, invigorating the spleen, and calming the mind. "Shennong's Herbal Classic" records that "it is used to treat chest evil qi and cough". "Shibuzhai Medical Book" records that "Poria is the main medicine for treating phlegm. The root of phlegm is water, and Poria can move water. The movement of phlegm is dampness, and Poria can also move dampness." This herb is sweet and light, and light can penetrate, so that dampness has nowhere to gather and phlegm has no reason to be generated, eliminating the source of phlegm, and promoting the normalization of the body's water metabolism, thereby achieving the effect of invigorating the spleen, invigorating dampness, and resolving phlegm. Modern pharmacological studies have shown that Poria has an enhanced immune function. Poria can antagonize aldosterone activity and increase the Na+ / K+ ratio in urine.

[0066] Scutellaria baicalensis: bitter, cold, enters the lung, gallbladder, spleen, stomach, large intestine, small intestine meridians. It has the effects of clearing heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. "Ben Cao Zheng" records that "the dry ones clear the fire of the upper jiao, eliminate phlegm and promote qi, stop wheezing and coughing, stop blood loss, and reduce alternating cold and heat, wind-heat, dampness and heat..." This product is bitter and cold in nature, mainly enters the lung meridian, is good at clearing and purging lung fire, and plays a role in clearing the lungs and purging fire in this prescription, reducing the occurrence of lung heat and cough. Modern pharmacological studies have shown that Scutellaria baicalensis has anti-inflammatory, anti-allergic, anti-allergic, antipyretic, detoxifying and anti-pathogen effects.

[0067] Pheretima: salty, cold, enters the liver, spleen, and bladder meridians. It has the effects of clearing heat, calming wind, unblocking meridians, relieving asthma, and diuresis. "Compendium of Materia Medica" records that it "is cold in nature and descends, and it can relieve various fevers because of its cold nature". This product is cold in nature and is good at clearing the lungs and relieving asthma. It plays the role of clearing heat and calming wind, unblocking meridians and lowering qi and relieving asthma in the formula. Modern pharmacological studies have found that the decoction of terrifera and the earthworm antipyretic alkali in it have a good antipyretic effect. The effective chemical component, terrifera hypoxanthine, has a significant bronchial dilation effect and can antagonize the contraction of histamine and pilocarpine on the bronchi. In addition, terrifera also has the effects of enhancing immunity, antibacterial, and lowering blood pressure.

[0068] Inula flower: bitter, pungent, salty, slightly warm, enters the lung and stomach meridians. It has the effects of descending qi and resolving phlegm, descending adverse qi and stopping vomiting. The purpose of wrapping and decocting is to prevent its villi from irritating the throat and causing itching, which may lead to coughing and vomiting. "Shennong's Herbal Classic" records that "it is used to treat qi stagnation, hypochondria, palpitations, remove water, remove cold and heat between the five internal organs, replenish the middle, and descend qi". "Compendium of Materia Medica" writes that "Inula flower is a medicine that eliminates phlegm and removes water, and promotes the downward movement of qi". This product is bitter, pungent, and opens the lungs, descends qi, resolves phlegm, and relieves asthma and cough. It has a good function of descending qi and resolving phlegm for the lung failure to descend caused by Mycoplasma pneumoniae infection, phlegm and dampness, and qi stagnation. Modern pharmacological studies have shown that Inula flower has obvious antitussive and expectorant effects. Inula flower flavonoids have a significant protective effect on histamine-induced bronchospastic asthma in guinea pigs, and also have an antagonistic effect on isolated bronchospasm.

[0069] Uncaria rhynchophylla: sweet, cool, belongs to the liver and pericardium meridians. It has the effects of clearing heat and calming the liver, calming wind and stopping spasms. "Compendium of Materia Medica" describes it as having the effect of "relaxing muscles and removing dizziness, lowering qi and widening the middle". "Compendium of Materia Medica" records that "Uncaria rhynchophylla can dispel wind and resolve phlegm, calm epilepsy, calm guests, and attack acne and eczema". This herb is sweet and cool in nature, and has the nature of light, clearing and dispersing. In this formula, it can clear heat and penetrate evil, evacuate wind and heat, lower qi and resolve phlegm and relieve asthma. Modern pharmacological studies have shown that Uncaria rhynchophylla has an antiasthmatic effect, and its active ingredient, total alkaloids of Uncaria rhynchophylla, can inhibit asthma caused by histamine. The active ingredient, Uncaria rhynchophylla alkaloids, has a significant inhibitory effect on arachidonic acid, thereby playing a role in immunomodulation and reducing inflammatory reactions. In addition, Uncaria rhynchophylla also has sedative, antihypertensive, antilipidemic and antiplatelet effects.

[0070] Ginger: pungent, warm, enters the lung, spleen, and stomach meridians. It has the effects of dispelling cold, warming the middle and stopping vomiting, warming the lungs and stopping coughing. "Famous Doctors' Records" describes it as "mainly for headache, stuffy nose, cough and shortness of breath caused by typhoid fever". "Medicinal Properties" records that "mainly for phlegm, water and qi, and lowering qi; raw and dried ginger can treat cough". It helps dispel wind evil, lower the adverse lung qi and stop coughing. At the same time, it warms the spleen and stomach and reduces the stimulation of drugs on the gastrointestinal tract. Modern pharmacological studies have shown that ginger can achieve anti-inflammatory and immunomodulatory effects by inhibiting the expression of inflammatory factors such as NF-κB and COX-2, and reducing the production of inflammatory mediators such as prostaglandin E2 and leukotrienes. It also enhances anti-infection ability by regulating macrophage activity. In addition, it also promotes the secretion of digestive juices and protects the gastric mucosa.

[0071] It should be understood that in the development process of any actual embodiment, such as in any Chinese medicine formulation design project, a large number of specific implementation decisions can be made. Such development efforts may be complex and time-consuming, but for those of ordinary skill who benefit from this disclosure, without excessive experimentation, the development efforts will be routine work for Chinese medicine formulation design, preparation and production.

[0072] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A Chinese medicine formula for treating cough caused by Mycoplasma pneumoniae infection, characterized in that: The prescription includes the following raw materials in parts by weight: 10 grams of ephedra, 10 grams of bitter almond, 10 grams of platycodon, 10 grams of licorice, 10 grams of perilla seed, 10 grams of pinellia, 10 grams of magnolia bark, 10 grams of poria, 10 grams of scutellaria, 10 grams of earthworm, 10 grams of inula flower (wrapped and decocted), 15 grams of Uncaria rhynchophylla (added later), and 5 grams of ginger.