Puncture needle and paclitaxel sequelae testing method and system using puncture needle

Abstract

The invention provides a puncture needle and a paclitaxel sequelae testing method and system applying the puncture needle, and belongs to the technical field of medical instruments. A hollow probe accommodating part is arranged in the main probe tube, and at least two probes are accommodated in the hollow probe accommodating part; each probe is provided with a first position and a second position in the probe accommodating part, and the probe at the first position is in a storage state and does not extend out of the main probe tube; the probe at the second position is in an extending state, and the head part of the probe can extend out of the main detection tube; the device further comprises a retraction device, and the retraction device is used for controlling the probe needle to retract when the main probe tube and / or the probe needle reaches a preset puncture depth upper limit, so that the test is finished. According to the invention, the limitation that the prior art depends on subjective evaluation singly is overcome, quantitative and standardized detection of neuropathy is realized, and the diagnosis sensitivity of paclitaxel sequelae is remarkably improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and particularly relates to a puncture needle, a test method and system for paclitaxel sequelae using the puncture needle. Background Art

[0002] Paclitaxel is a chemotherapy drug widely used in cancer treatment, and has shown significant efficacy particularly in the treatment of malignant tumors such as breast cancer, ovarian cancer and non-small cell lung cancer. Its mechanism of action is mainly to inhibit the depolymerization of microtubules and interfere with the mitosis of cancer cells, thereby achieving the purpose of inhibiting tumor growth. Although paclitaxel has achieved positive results in treating tumors, its sequelae cannot be ignored.

[0003] Research shows that a considerable proportion of patients using paclitaxel will experience symptoms of nerve ending poisoning, manifested as numbness, pain and loss of sensation in the fingertips and toes. This kind of nerve damage, usually called chemotherapy-related peripheral neuropathy, has a significantly higher incidence in female patients than in male patients, and has a certain degree of randomness, affecting the quality of life of patients.

[0004] Existing detection techniques mainly rely on the observation of clinical symptoms and regular neurological function assessments. This method often makes it difficult to diagnose and evaluate the degree of nerve damage in patients in a timely and accurate manner. Due to the lack of effective detection tools, doctors often face the dilemma of insufficient information when formulating corresponding prevention and treatment measures.

[0005] The solution to this problem is not only of great significance for the monitoring of paclitaxel sequelae, but also crucial for the formulation of subsequent rehabilitation and physiotherapy programs.

[0006] In summary, how to provide a detection tool suitable for paclitaxel sequelae is a technical problem that urgently needs to be solved at present. Summary of the Invention

[0007] The purpose of the present invention is to overcome the deficiencies of the prior art, and provide a puncture needle, a test method and system for paclitaxel sequelae using the puncture needle, which can collect the pain response of patients through the mechanical puncture function, so as to determine the severity of paclitaxel sequelae.

[0008] The present invention provides a puncture needle, including, A main detection tube, in which a hollow detection needle accommodation part is provided, and at least two detection needles are accommodated therein; For each detection needle, in the detection needle accommodation part, it has a first position and a second position. The detection needle is in a retracted state at the first position and does not extend out of the main detection tube; the detection needle is in an extended state at the second position, and the needle tip part of the detection needle can extend out of the main detection tube; It further includes a retraction device configured to control the retraction of the detection needle and end the test when the main detection tube and / or the detection needle reach the upper limit of the preset puncture depth.

[0009] Furthermore, the detection needle accommodating portion can be opened and closed; in the open state, the detection needle accommodating portion communicates with the outside; a detection needle switching component is arranged inside the detection needle accommodating portion for changing the position of the detection needle within the main detection tube. The detection needle switching component includes a rotary turntable switching structure, a slider propulsion switching structure, an electromagnetic drive switching structure, or a gear-rack linkage switching structure.

[0010] Furthermore, it also includes an electrical stimulation component including electrodes with opposite polarities. The electrodes with opposite polarities are respectively arranged on the detection needle. Alternatively, the electrodes with opposite polarities are respectively arranged on the detection needle and the main detection tube. The retraction device is configured to turn off the electrical stimulation component and end the test when the current intensity output by the electrical stimulation component reaches the upper limit of the preset current intensity.

[0011] Furthermore, the upper airbag includes a single upper airbag or a plurality of superimposed upper sub-airbags, and the upper sub-airbags are selectively interconnected.

[0012] The present invention provides a method for testing paclitaxel sequelae implemented by a puncture needle as described in any one of the above, including the following steps: S1 When the main detection tube contacts the human skin, insert the detection needle through the main detection tube so that at least the needle tip portion of the detection needle extends outside the main detection tube, and selectively apply puncture stimulation, electrical stimulation, or a combination thereof. S2 Collect the corresponding pain responses of the patient under the stimulation of the detection needle. S3 Based on the pain responses, obtain a comprehensive pain score value, and based on the comprehensive pain score value, determine the severity of paclitaxel sequelae.

[0013] Furthermore, S2 includes collecting the subjective feelings of the patient towards pain; collecting the image data of the patient during the stimulation process, including facial image data, the voice data of the patient, and / or the limb movement data of the patient.

[0014] Furthermore, S2 includes obtaining a subjective pain score value based on the subjective feelings of the patient. Based on the image data of the patient, obtain an objective pain score value. Superimpose the subjective pain score value and the objective pain score value according to a preset weight coefficient, and calculate to obtain the comprehensive pain score value of the patient.

[0015] Further, obtain the deviation value between the patient's subjective pain assessment score and the objective pain score, compare the deviation value with a preset threshold. If the deviation value is greater than the preset threshold, it is determined that the evaluation result is abnormal, and an alarm message is output.

[0016] Further, it also includes recording the final pain score value and the corresponding subject parameter data, and establishing a stimulus-response mapping database. The subject parameter data includes at least one of the main detection tube puncture depth data, the detection needle specification data, the detection needle puncture depth data, and / or the electrical stimulation parameter data of the electrode.

[0017] Further, collect the patient's personal data, where the personal data includes physiological data and medical record data, and the medical record data at least includes paclitaxel medication data. Based on the patient's personal data, search for a matching case in the stimulus-response mapping database, and obtain the subject parameter data of this case as the patient's initial stimulation parameters.

[0018] The present invention provides a system adopting the paclitaxel sequelae test method described in any one of the above. This system includes the paclitaxel sequelae detection puncture needle described in any one of the above. The pain response acquisition module is configured to collect the corresponding pain response of the patient under the stimulation of this detection needle. The evaluation module is configured to obtain a comprehensive pain score value based on the pain response evaluation, and determine the severity of the paclitaxel sequelae based on the comprehensive pain score value.

[0019] Due to adopting the above technical solutions, compared with the prior art, for example, the present invention has the following advantages and positive effects: Adopt a split design of the detection needle accommodating part and the main detection tube, combined with the function of a switchable detection needle, support the rapid adaptation and replacement of detection needles with different specifications during the operation, reduce the risk of cross-contamination, and at the same time meet the composite scenario requirements of shallow evaluation and deep detection, greatly improving the operation flexibility. Integrate the functions of mechanical puncture and electrophysiological stimulation, overcome the limitations of the prior art that solely rely on subjective evaluation, realize the quantitative and standardized detection of neuropathy, and significantly improve the diagnostic sensitivity for paclitaxel sequelae.

[0020] Evaluate the patient's pain response through multi-dimensional data such as questionnaires, facial micro-expressions, voice characteristics, and body movements, combined with the patient's subjective pain response and the patient's objective pain response, obtain the patient's comprehensive pain score value, and thus determine the severity of the paclitaxel sequelae. Construct a warning mechanism for the conflict between subjective and objective scores, enhance the evaluation reliability, provide a precise quantitative basis for doctors to formulate rehabilitation plans, and reduce the misjudgment rate.

[0021] The present invention systematically addresses the pain points of existing detection technologies, such as relying on subjective experience, having a lag in response, and insufficient typing ability. It constructs a complete closed-loop from stimulus application, data collection to decision feedback, improving the detection efficiency of the sequelae of paclitaxel chemotherapy while providing technical empowerment for the planning of individualized treatment paths. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 It is a flowchart of the steps of the method for testing the sequelae of paclitaxel provided by the present invention.

[0023] Figure 2 It is a partial structural schematic diagram of the puncture needle provided by the present invention.

[0024] Figure 3 It is a schematic diagram of the connection between the electrical stimulation component and the puncture needle provided by the present invention.

[0025] Figure 4 It is a schematic diagram of the connection between the electrical stimulation component and the puncture needle provided by the present invention, which is another embodiment.

[0026] DESCRIPTION OF THE REFERENCE NUMERALS Puncture needle 100; Main detection tube 200; Detection needle 300; Detection needle accommodation part 400; Detection needle switching component 500; Electrical stimulation component 600, positive electrode 610, negative electrode 620. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0027] The following further details the technical solutions disclosed by the present invention in conjunction with the accompanying drawings and specific embodiments. It should be noted that the technical features described in the following embodiments or the combination of technical features should not be considered in isolation, and they can be combined with each other to achieve better technical effects. In the accompanying drawings of the following embodiments, the same reference numerals in each drawing represent the same features or components, which can be applied to different embodiments. Therefore, once an item is defined in one drawing, it does not need to be further discussed in subsequent drawings.

[0028] It should be noted that the structures, proportions, sizes, etc. shown in the drawings of this specification are only used to cooperate with the content disclosed in the specification for those who are familiar with this technology to understand and read, and are not used to limit the conditions for the implementation of the invention. Any modification of the structure, change of the proportional relationship or adjustment of the size, without affecting the effects that the invention can produce and the purposes that can be achieved, should fall within the scope covered by the technical content disclosed by the invention. The scope of the preferred implementation mode of the present invention includes additional implementations, in which the functions can be executed in a substantially simultaneous manner or in the reverse order according to the functions involved, rather than in the order described or discussed. This should be understood by those skilled in the art to which the embodiments of the present invention belong.

[0029] Technologies, methods, and devices known to those of ordinary skill in the relevant fields may not be discussed in detail, but where appropriate, the said technologies, methods, and devices should be regarded as part of the specification. In all the examples shown and discussed here, any specific values should be construed as merely exemplary, rather than as limitations. Therefore, other examples of the exemplary embodiments may have different values.

[0030] The present invention provides a puncture needle 100 for detecting the sequelae of paclitaxel.

[0031] It includes a main detection tube 200. The top end of the main detection tube 200 has sharpness and can contact the patient's skin. And under a certain pressure, it can pierce the patient's skin and reach under the patient's skin.

[0032] A hollow detection needle accommodating part 400 is arranged in the main detection tube 200. The detection needle accommodating part 400 and the detection needle 300 are detachably connected, which is convenient for updating the detection needle 300.

[0033] At least two detection needles 300 are accommodated in the detection needle accommodating part 400. The detection needle accommodating part 400 includes a first position and a second position. The detection needle 300 in the first position is in a received state. For example, the area is divided by a receiving groove with a limiting boss or a snap-in partition. The detection needle 300 is completely located inside the main detection tube 200, and the needle tip keeps a safe distance from the outlet and does not extend outside the main detection tube 200.

[0034] While the detection needle 300 in the second position is in an extended state, and the needle tip part can extend outside the outlet where the main detection tube 200 communicates with the outside, and then contact the patient's skin.

[0035] Furthermore, when the detection needle 300 reaches the second position, the card slot at the needle tail is engaged with the elastic locking pin of the accommodating part, such as a spring steel ball, to prevent the needle body from retracting during the puncture process.

[0036] More than one detection needle 300 is provided to facilitate the replacement of the required detection needle 300 according to different clinical situations.

[0037] The detection needles 300 are of different specifications. Specifically, they include the thickness and length of the needle body, as well as the sharpness of the needle tip.

[0038] When the detection needles 300 of different specifications are used to perform contact operations or puncture operations on the skin of the patient, different pain stimulation effects can be brought.

[0039] By way of example and not limitation, ultra-fine needles with a diameter of less than 0.3 mm are used for superficial mild stimulation assessment, and medium-thick needles with a diameter of 0.5 - 1.0 mm are used for medium-severe pain response testing.

[0040] Sharp needles with a needle tip cone angle less than 15° are used for precise stimulation in areas where superficial nerve endings are concentrated, and blunt needles with a cone angle of 20 - 30° are used to simulate tissue compressive pain.

[0041] The switching of the detection needle 300 can be carried out manually or automatically.

[0042] In the case of manual replacement, the detection needle accommodating part 400 is set to be able to open and close. For example: Sliding cover plate type: A strip-shaped groove is opened on the side wall of the accommodating part, and the cover plate is translated along the groove through a slide rail and fixed by a magnetic snap when closed to prevent the cover plate from accidentally falling off during the opening and closing process.

[0043] Hinge flip type: The top of the accommodating part is connected to the flip cover through a micro hinge, and a rubber sealing ring is provided on the inner side of the flip cover to prevent contamination.

[0044] In the open state, the detection needle accommodating part 400 is communicated with the outside. At this time, the user can manually take out the detection needle 300 and put in other specification detection needles 300. Or, the operator does not need to take out the detection needle 300, but manually changes the position of the detection needle 300 in the detection needle accommodating part 400, and moves the required detection needle 300 from the first position to the second position for subsequent operations.

[0045] Specifically, a transverse push rod is provided on the outer wall of the detection needle accommodating part 400, and the push rod is connected to the tail of the detection needle 300. When the operator pushes forward to the second position, a locking structure such as a ratchet and rack is triggered, and when pulled back to the first position, the unlocking button is pressed to release the lock.

[0046] Optionally, a transparent observation window is provided on the outer surface of the main detection tube 200, the detection needle 300 numbers and / or mechanical pointer scales are marked, and the position of the detection needle 300 is linked, so that the operator can quickly identify the specification of the detection needle 300 currently in the second position without opening the container.

[0047] Further, it further includes a probe needle switching component 500 disposed within the probe needle accommodating portion 400.

[0048] The probe needle switching component 500 can change the position of the probe needle 300 relative to the outlet of the main probe tube 200, thereby switching the probe needle 300 for the required operation.

[0049] In one implementation, the probe needle switching component 500 is a rotary turntable type switching structure.

[0050] It includes a turntable base, fixed to the inner wall of the probe needle accommodating portion 400, and its axis is coaxial with the main probe tube 200.

[0051] Probe needle slots distributed in a circumferential manner, the number of which matches the number of probe needles 300, and each slot is embedded with a guiding track.

[0052] A turntable rotation driving mechanism, which is selected as a manual lever or a micro stepping motor for example.

[0053] When the turntable base rotates, the needle tails of the respective probe needles 300 are rigidly connected to the turntable through an adapter interface, and the positions of their needle heads are adjusted along the circumferential movement track of the turntable. By rotating the turntable at a specific angle, the target probe needle 300 is aligned with the outlet axis of the main probe tube 200. The turntable is locked by a limit buckle, for example, a spring-loaded ball cooperates with the turntable groove to ensure the alignment accuracy when the probe needle 300 extends.

[0054] In another implementation, the probe needle switching component 500 is a slider propulsion type switching structure.

[0055] It at least includes: a slide rail base body, a guide rail system parallel to the axis of the main probe tube 200, arranged along the long axis of the accommodating portion.

[0056] A split slider, each slider fixes the needle tail of a single probe needle 300, and a guide groove matching the slide rail is provided at the bottom of the slider.

[0057] It may further include: a two-way spring locking module, such as when the slider travels to a preset position, the bilateral spring steel balls are embedded in the positioning concave holes of the slider.

[0058] The operator drives the slider to linearly move along the slide rail through an external lever or push button, so that different probe needles 300 slide to the outlet axis in sequence. The nested multi-layer stacking design of the slider can reduce the overall volume. For example, the sliders are arranged in a stepped layout, and the lower slider gives way to the upper slider during propulsion to achieve independent stroke control of multiple needles.

[0059] In another implementation, the probe needle switching component 500 is an electromagnetic drive type switching structure.

[0060] It includes a micro electromagnetic driver, and a permanent magnet ring is sleeved on the tail of each probe needle 300.

[0061] An electromagnet array, with multiple coils circumferentially distributed along the accommodating part, which generate a directional magnetic field after being energized.

[0062] Select the electromagnet corresponding to the target detection needle 300 to be energized, and attract the permanent magnet ring at the tail of the detection needle 300 through magnetic force, so that it moves horizontally towards the outlet direction. Similar electromagnets can adopt a segmented activation strategy. For example: the coils are energized in a time-sharing manner to guide the detection needle 300 to slide to the outlet position, and the in-place state of the detection needle 300 is detected by a Hall sensor to cut off the electromagnetic force.

[0063] In another implementation, the detection needle switching component 500 is a gear-rack linkage switching structure.

[0064] Multiple segmented racks, with an independent rack fixedly connected to the tail of each detection needle 300, and the racks are arranged in parallel.

[0065] A gear selector, a driving gear that can move axially, and its meshing state with different racks is controlled by a manual knob.

[0066] Push the gear selector slider forward so that the gear part only meshes with the rack corresponding to the target detection needle 300. When the knob is rotated, the gear drives the rack and the detection needle 300 to extend. The unmeshed racks remain stationary due to lack of power input. This structure can adjust the fine extension amount of the probe by adjusting the gear module.

[0067] Preferably, it further includes a retraction device (not shown in the figure) integrated in the main detection tube 200, which includes the following core components: A puncture depth monitoring module. As a typical implementation, it includes; Engrave scale lines on the surface of the needle body of the detection needle 300, and fix a magnetic mark at the needle tail; a linear Hall sensor array is arranged on the inner wall of the main detection tube 200, and the puncture depth is calculated in real time by detecting the displacement amount of the magnetic mark.

[0068] An actuator. As a typical implementation, it includes; a gear-ratchet linkage mechanism: a reversible stepper motor is provided in the detection needle accommodating part 400, the driving gear meshes with the rack at the tail end of the detection needle 300, and the needle body is retracted by reversing the motor.

[0069] When the puncture depth monitoring module detects that the depth reaches the preset upper limit of the puncture depth, it sends a signal to the control chip; the chip triggers the stepper motor to reverse, driving the detection needle 300 to retract until the needle tip completely retracts into the main detection tube 200; at the same time, the detection needle switching component 500500 is locked to prevent the detection needle 300 from extending again during this test.

[0070] The implementation of the main detection tube 200 is the same in principle.

[0071] Optionally, it further includes an electrical stimulation component 600, and the electrical stimulation component 600 includes a positive electrode 610 and a negative electrode 620.

[0072] In one implementation, the electrical stimulation component 600 is disposed on the needle body of the detection needle 300.

[0073] As a typical implementation, an annular groove is machined on the needle body of the detection needle 300. The positive electrode 610 is embedded in the groove near the tip of the needle, and the negative electrode 620 is fixed in the middle of the needle body. An insulating coating, such as parylene, is filled between the two electrodes, and only the surface of the electrode ring is exposed to achieve directional current flow, forming a local stimulation area.

[0074] In another implementation, the electrical stimulation component 600 is respectively disposed on the front end portions of the detection needle 300 and the main detection tube 200.

[0075] For example, a ring-shaped electrode is embedded at the front end of the main detection tube 200 as the positive electrode, and the tip of the detection needle 300 is used as the negative electrode. The electrode ring and the outer wall of the main detection tube 200 are connected to an external power supply interface through an embedded wire.

[0076] Furthermore, the retraction device includes: An electrical stimulation intensity monitoring module. As a typical implementation, a precision current sensor is connected in series in the electrode wire of the electrical stimulation component 600 to collect the output current value in real time.

[0077] If the output current of the electrical stimulation component 600 continuously exceeds the preset upper limit of the current intensity, the current sensor sends an overload signal; the control chip immediately cuts off the power supply circuit of the electrode.

[0078] When performing puncture and electrical stimulation simultaneously, when any one of the conditions is met, that is, the main detection tube 200 and / or the detection needle 300 reaches the preset upper limit of the puncture depth, or the current intensity output by the electrical stimulation component 600 reaches the preset upper limit of the current intensity, the retraction device immediately stops the test of the stimulation operation exceeding the preset upper limit, so that the stimulation intensity is limited within a reasonable range.

[0079] The present invention also provides a pain assessment method using the paclitaxel sequelae detection puncture needle 100 described in any one of the above.

[0080] When the main detection tube 200 contacts the human skin, the detection needle 300 is passed through the main detection tube 200 so that at least the tip portion of the detection needle 300 extends outside the main detection tube 200, and stimulation is applied.

[0081] The contact here includes contacting the surface of the human skin and / or below the surface of the human skin.

[0082] The detection needle 300 applies stimulation mainly by puncturing the surface skin of the human body to enter below the skin surface, and optionally, by applying electrical stimulation through the electrode assembly.

[0083] The degree of stimulation applied can be adjusted in the following ways: The puncture depth of the main detection tube 200.

[0084] By switching detection needles 300 of different specifications and the puncture depth of the detection needle 300.

[0085] In specific implementation, a systematic gradient stimulation method can be adopted. Specifically, by presetting a pain score threshold, when the pain score < threshold after the first stimulation, the next round will automatically switch to a detection needle 300 of a higher specification; if the score ≥ threshold, the stimulation intensity will be maintained or reduced until the pain sensitive critical point is found.

[0086] In the case where an electrode assembly is provided, different pain stimulations are applied by adjusting the current parameters.

[0087] In specific implementation, when a significant response is not triggered by simple mechanical stimulation, the system prompts to activate the electrical stimulation assembly 600. After receiving the operator's confirmation instruction to start, the system automatically triggers the electrical stimulation assembly 600 and matches the initial current parameters based on the current puncture depth.

[0088] Similarly, in the case of combined electrical stimulation, a similar systematic gradient stimulation method as above can also be adopted. When the pain score < threshold after the first stimulation, the next round will automatically switch to a detection needle 300 of a higher specification, and / or increase the current parameters; if the score ≥ threshold, the stimulation intensity will be maintained or reduced until the pain sensitive critical point is found.

[0089] Collect the corresponding pain response of the patient under the stimulation of the detection needle 300, and obtain the pain score value based on the pain response evaluation.

[0090] The pain score value includes a subjective pain score value and an objective pain score value.

[0091] It can be carried out in various ways: Collect the subjective feelings of the patient about pain through a questionnaire survey, and let the patient evaluate their pain degree through preset questions.

[0092] Specifically, for example, the VAS (Visual Analogue Scale) or NRS (Numeric Rating Scale) is adopted, and within 30 seconds after each stimulation is applied (to avoid memory bias), the patient completes the scoring by dragging a slider or clicking on a number through a handheld terminal (tablet computer) to obtain the subjective pain score value.

[0093] During the stimulation process, the patient's image data is collected, mainly including facial image data, the patient's voice data, and / or the patient's body movement data. By analyzing the patient's image data, the patient's pain level is evaluated to obtain an objective pain score value.

[0094] The facial image data evaluation here can be implemented using existing technology. For example, a lightweight convolutional neural network (CNN) is run through an embedded GPU to detect micro-expression indicators such as forehead wrinkle intensity, eyelid closure speed, and nasolabial fold deepening in real time, and output the pain score value corresponding to the facial image data.

[0095] Sound data is collected through a camera or microphone, and sound features are extracted after filtering out environmental noise. Examples include the following features: considering that pain causes patients to increase the volume of the sound, the decibel of the sound is extracted as a feature; the duration of the sound; considering that pain causes increased tension in the vocal cords, the fundamental frequency increase rate is extracted as a feature; considering that the ability to control vocalization under pain decreases, the vowel / a: / pronunciation duration shortening rate is extracted as a feature.

[0096] Based on the above sound characteristics, the pain is judged and evaluated to obtain the corresponding pain score value.

[0097] Limb movement data can be collected through image data and wearable devices. For example, the patient wears a three-axis accelerometer on the wrist to monitor the peak acceleration of the hand retraction movement and the torso twisting angle. As an example and not limitation, when the acceleration exceeds a threshold (such as ≥2g) or the twisting angle is greater than 15°, it is judged as a significant avoidance reaction and marked as a high-intensity pain signal.

[0098] Based on the degree of deviation between the limb movement data and the preset threshold, the corresponding pain score value is obtained.

[0099] The pain score values ​​corresponding to the above data are summarized, and an objective pain score value is obtained after superposition or weighted calculation.

[0100] The final pain score is calculated by assigning different weights to the subjective pain score and the objective pain score.

[0101] Furthermore, the final pain score value and the corresponding subject parameter data are recorded to establish a stimulus-response mapping database.

[0102] The main parameter data here refers to the parameter data of the puncture needle 100 body used to implement pain stimulation, including at least one of the puncture depth data of the main detection tube 200, the specification data of the detection needle 300, the puncture depth data of the detection needle 300 and / or the electrical stimulation parameter data of the electrode.

[0103] The personal data of the patient, by way of example and not limitation, includes the patient's physiological data and medical record data.

[0104] Physiological data refers to personal data related to the patient's physiology such as the patient's age, height, weight, etc.

[0105] Medical record data includes the patient's condition data and the patient's medication data, where the medication data at least includes paclitaxel medication data.

[0106] When a new patient undergoes pain assessment for the first time, based on the patient's personal data, similar cases in the stimulus-response mapping database are matched, such as "diabetes + paclitaxel dose of 135 - 175 mg / m² + age of 60 - 70 years", and the main parameter data of this case is obtained as the patient's initial stimulus parameter.

[0107] The first-round pain assessment is carried out using this initial stimulus parameter. Based on the obtained pain score value of the patient, subsequently, according to the situation, the main stimulus parameter can be adjusted in accordance with the pain adjustment method described above.

[0108] In addition, when there is a large difference and conflict between the patient's subjective pain score, such as VAS ≤ 3, and the objective pain score, such as the trunk torsion angle > 20° during the probe 300 puncture, through the statistical distribution of the database, for example, "only 5% of patients show this action intensity when VAS ≤ 3", it is determined that the assessment result is abnormal, and an alarm message is output to prompt the patient and relevant staff that a retest is required.

[0109] Based on the comprehensive pain score value, the severity of paclitaxel sequelae is determined.

[0110] By way of example, the evaluation mechanism is set as follows:

[0111] Within the scope of the object protection of this disclosure, terms such as "including" should be construed as inclusive or open by default, rather than exclusive or closed, unless it is explicitly defined to have the opposite meaning. All technical, scientific or other terms conform to the meaning understood by those skilled in the art, unless it is defined to have the opposite meaning. Common terms found in the dictionary should not be interpreted too idealistically or too unrealistically in the context of relevant technical documents, unless this disclosure explicitly defines it as such.

[0112] For those skilled in the art, it is obvious that the present invention is not limited to the details of the above-described exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, in any aspect, the embodiments should be regarded as exemplary and non-limiting. The scope of the present invention is defined by the appended claims rather than the above description. Therefore, all changes falling within the meaning and scope of the equivalent elements of the claims are intended to be embraced within the present invention. Any reference signs in the claims should not be construed as limiting the claims involved.

[0113] In addition, it should be understood that although this specification is described in terms of embodiments, not every embodiment only contains an independent technical solution. This narrative manner of the specification is only for clarity. Those skilled in the art should regard the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A puncture needle, characterized in that include, A main detection tube, wherein a hollow detection needle receiving portion is provided in the main detection tube, and at least two detection needles are placed in the hollow detection needle receiving portion; Each detection needle has a first position and a second position in the detection needle accommodating portion. The detection needle in the first position is in a stored state and does not extend out of the main detection tube; the detection needle in the second position is in an extended state, and the needle head of the detection needle can extend out of the main detection tube; It also includes a retraction device, which is used to control the detection needle to retract when the main detection tube and / or the detection needle reaches a preset upper limit of the puncture depth to end the test.

2. The puncture needle according to claim 1, characterized in that: The detection needle receiving part can be opened and closed; in the open state, the detection needle receiving part is connected to the outside; a detection needle switching component is arranged in the detection needle receiving part for changing the position of the detection needle in the main detection tube; The detection needle switching assembly includes a rotating turntable switching structure, a slider push switching structure, an electromagnetic drive switching structure or a gear rack linkage switching structure.

3. The puncture needle according to claim 2, characterized in that: Also included is an electrical stimulation assembly including electrodes of opposite polarity; Electrodes with opposite polarities are respectively arranged on the detection needles; Alternatively, electrodes with opposite polarities are respectively arranged on the detection needle and the main detection tube; The retraction device is used to turn off the electrical stimulation component and end the test when the current intensity output by the electrical stimulation component reaches a preset upper limit of the current intensity.

4. A method for testing the sequelae of paclitaxel achieved by the puncture needle according to any one of claims 1 to 3, characterized in that: The steps include: S1 When the main detection tube contacts the human skin, the detection needle is passed through the main detection tube so that at least the needle tip of the detection needle extends out of the main detection tube, and puncture stimulation, electrical stimulation or a combination thereof is selectively applied; S2 collects the patient's corresponding pain response under the stimulation of the detection needle; S3 obtains a comprehensive pain score based on pain response assessment, and determines the severity of paclitaxel sequelae based on the comprehensive pain score.

5. The method for testing the sequelae of paclitaxel according to claim 4, characterized in that: S2 includes collecting the patient's subjective feeling of pain; collecting the patient's image data during the stimulation process, including facial image data, the patient's voice data, and / or the patient's body movement data.

6. The method for testing the sequelae of paclitaxel according to claim 5, characterized in that: S2 includes obtaining the patient's subjective pain score based on the patient's subjective feelings; Obtaining the patient's objective pain score based on the patient's image data; The subjective pain score and the objective pain score are superimposed according to the preset weight coefficient to calculate the patient's comprehensive pain score.

7. The method for testing the sequelae of paclitaxel according to claim 6, characterized in that: Obtain the deviation value between the patient's subjective pain assessment score and the objective pain score, compare the deviation value with the preset threshold, and if the deviation value is greater than the preset threshold, the assessment result is judged to be abnormal and an alarm message is output.

8. The method for testing the sequelae of paclitaxel according to claim 4, characterized in that: It also includes recording the final pain score value and the corresponding subject parameter data to establish a stimulus-response mapping database; The main body parameter data includes at least one of the main detection tube puncture depth data, detection needle specification data, detection needle puncture depth data and / or electrode electrical stimulation parameter data.

9. The method for testing the sequelae of paclitaxel according to claim 8, characterized in that: Collecting personal data of the patient, wherein the personal data includes physiological data and medical record data, and the medical record data includes at least paclitaxel medication data; Based on the patient's personal data, a matching case is searched in the stimulus-response mapping database, and the subject parameter data of the case is obtained as the patient's initial stimulation parameters.

10. A test system using the paclitaxel sequelae test method as claimed in claims 4 to 9, characterized in that: The system comprises the puncture needle as described in claims 1-3; The pain response collection module is configured to collect the patient's corresponding pain response under the stimulation of the puncture needle; The evaluation module is configured to obtain a comprehensive pain score based on the pain response evaluation, and determine the severity of paclitaxel sequelae based on the comprehensive pain score.

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