Fractional flow reserve score determination method and device, electronic equipment and readable storage medium

Abstract

The invention discloses a fractional flow reserve determination method and device, electronic equipment and a readable storage medium, and the method comprises the steps: obtaining at least two stages of magnetic resonance medical images of a target blood vessel based on a time sequence; based on the at least two stages of magnetic resonance medical images, contrast agent change information in the target blood vessel is determined; based on the contrast agent change information, the fractional flow reserve corresponding to the target blood vessel is determined. Based on the at least two stages of magnetic resonance medical images, the contrast agent change information in the target blood vessel is determined, then the fractional flow reserve corresponding to the target blood vessel is determined according to the contrast agent change information, and the fractional flow reserve determination accuracy can be improved.

Description

Technical Field

[0001] This application relates to the technical field of medical image processing, and particularly to a method, device, electronic device, and readable storage medium for determining fractional flow reserve. Background Art

[0002] Fractional flow reserve is considered the "gold standard" for judging the degree of ischemia of diseased blood vessels. Currently, a non-invasive method for calculating fractional flow reserve based on CT coronary angiography has been developed.

[0003] However, CT images are static images, and the blood flow data extracted from CT images is not accurate enough, which will have a greater impact on the subsequent prediction of fractional flow reserve. Summary of the Invention

[0004] Embodiments of this application provide a method, device, electronic device, and readable storage medium for determining fractional flow reserve. Based on at least two-phase magnetic resonance medical images, the contrast agent change information in the target blood vessel is determined, and then the fractional flow reserve corresponding to the target blood vessel is determined according to the contrast agent change information, which can improve the accuracy of determining fractional flow reserve.

[0005] In a first aspect, embodiments of this application provide a method for determining fractional flow reserve, the method comprising:

[0006] Obtain at least two-phase magnetic resonance medical images of a target blood vessel based on the time sequence;

[0007] Determine the contrast agent change information in the target blood vessel based on the at least two-phase magnetic resonance medical images;

[0008] Determine the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information.

[0009] Optionally, the determining the contrast agent change information in the target blood vessel based on the at least two-phase magnetic resonance medical images includes:

[0010] Identify each phase of the magnetic resonance medical images respectively to determine the contrast agent distribution corresponding to each phase of the magnetic resonance medical images;

[0011] Compare the contrast agent distributions corresponding to the at least two-phase magnetic resonance medical images to determine the contrast agent change information in the target blood vessel.

[0012] Optionally, the identifying each phase of the magnetic resonance medical images respectively to determine the contrast agent distribution corresponding to each phase of the magnetic resonance medical images includes:

[0013] For each period of the magnetic resonance medical images, preprocess the magnetic resonance medical images to obtain target magnetic resonance medical images;

[0014] Obtain the pixel brightness value of each pixel point in the target magnetic resonance medical image, and determine the distribution of the contrast agent corresponding to the magnetic resonance medical image according to the pixel brightness value and a preset mapping relationship; the preset mapping relationship is the mapping relationship between the pixel brightness value and the contrast agent concentration.

[0015] Optionally, comparing the distributions of the contrast agents corresponding to at least two periods of the magnetic resonance medical images to determine the change information of the contrast agent in the target blood vessel includes:

[0016] Using one period of the magnetic resonance medical image as a reference image, register at least two periods of the magnetic resonance medical images;

[0017] Compare the distributions of the contrast agents corresponding to at least two periods of the registered magnetic resonance medical images to determine the change information of the contrast agent in the target blood vessel.

[0018] Optionally, determining the fractional flow reserve corresponding to the target blood vessel based on the change information of the contrast agent includes:

[0019] Based on at least two periods of the magnetic resonance medical images, determine the blood vessel lesion area in the target blood vessel;

[0020] Based on the change information of the contrast agent and the blood vessel morphological change information and blood vessel blood flow change information corresponding to at least two periods of the magnetic resonance medical images, determine the reference blood flow information corresponding to the blood vessel lesion area;

[0021] According to the reference blood flow information, determine the fractional flow reserve corresponding to the target blood vessel.

[0022] Optionally, the reference blood flow information includes the reference blood flow volume, and determining the fractional flow reserve corresponding to the target blood vessel according to the reference blood flow information includes:

[0023] Obtain the target blood flow volume corresponding to the target blood vessel, and the target blood flow volume is the blood flow volume when there is no lesion in the target blood vessel;

[0024] Calculate the ratio of the reference blood flow volume and the target blood flow volume, and determine the fractional flow reserve corresponding to the target blood vessel.

[0025] Optionally, determining the change information of the contrast agent in the target blood vessel based on at least two periods of the magnetic resonance medical images includes:

[0026] Segment the vascular regions in at least two periods of the magnetic resonance medical images to obtain vascular region images corresponding to each period of the magnetic resonance medical images;

[0027] Perform recognition processing on the vascular region images corresponding to each period of the magnetic resonance medical images respectively to determine the contrast agent distribution corresponding to the vascular region images of each period;

[0028] Compare the contrast agent distributions corresponding to the vascular region images of at least two periods to determine the contrast agent change information in the target blood vessel.

[0029] In a second aspect, an embodiment of the present application provides a fractional flow reserve determination device, and the fractional flow reserve determination device includes:

[0030] An acquisition unit, configured to acquire at least two periods of magnetic resonance medical images of a target blood vessel based on the time sequence;

[0031] A first determination unit, configured to determine the contrast agent change information in the target blood vessel based on at least two periods of the magnetic resonance medical images;

[0032] A second determination unit, configured to determine the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information.

[0033] In a third aspect, an embodiment of the present application further provides an electronic device, including a memory storing a computer program; a processor loads the computer program from the memory to execute the steps of any one of the fractional flow reserve determination methods provided by the embodiments of the present application.

[0034] In a fourth aspect, an embodiment of the present application further provides a computer-readable storage medium, and the computer-readable storage medium stores a computer program, and the computer program is suitable for being loaded by a processor to execute the steps of any one of the fractional flow reserve determination methods provided by the embodiments of the present application.

[0035] In a fifth aspect, an embodiment of the present application further provides a computer program product, including a computer program, and the steps in any one of the fractional flow reserve determination methods provided by the embodiments of the present application are implemented when the computer program is executed by a processor.

[0036] Adopting the solution of the embodiments of the application, based on the time sequence, acquire at least two periods of magnetic resonance medical images of the target blood vessel; based on at least two periods of the magnetic resonance medical images, determine the contrast agent change information in the target blood vessel; based on the contrast agent change information, determine the fractional flow reserve corresponding to the target blood vessel. Determining the contrast agent change information in the target blood vessel based on at least two periods of magnetic resonance medical images, and then determining the fractional flow reserve corresponding to the target blood vessel according to the contrast agent change information can improve the accuracy of determining the fractional flow reserve. Brief Description of the Drawings

[0037] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those skilled in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0038] Figure 1 It is a schematic flowchart of the first embodiment of the method for determining fractional flow reserve provided by the present application;

[0039] Figure 2 It is a schematic flowchart of the second embodiment of the method for determining fractional flow reserve provided by the present application;

[0040] Figure 3 It is a schematic flowchart of the third embodiment of the method for determining fractional flow reserve provided by the present application;

[0041] Figure 4 It is a schematic flowchart of the fourth embodiment of the method for determining fractional flow reserve provided by the present application;

[0042] Figure 5 It is a schematic structural diagram of the device for determining fractional flow reserve provided by the embodiments of the present application;

[0043] Figure 6 It is a schematic structural diagram of the device for determining fractional flow reserve provided by the embodiments of the present application. Detailed Description of the Embodiments

[0044] The following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without creative efforts belong to the scope of protection of the present application. At the same time, in the description of the embodiments of the present application, the terms "first", "second", etc. are only used for distinguishing descriptions and cannot be understood as indicating or implying relative importance. Thus, the features defined with "first", "second" may explicitly or implicitly include one or more features. In the description of the embodiments of the present application, "a plurality" means two or more, unless otherwise clearly and specifically defined.

[0045] The embodiments of the present application provide a method, a device, an electronic device, and a readable storage medium for determining fractional flow reserve.

[0046] Specifically, this embodiment will be described from the perspective of a fractional flow reserve determination device, which can be specifically integrated in a fractional flow reserve determination apparatus. That is, the fractional flow reserve determination method in the embodiments of the present application can be executed by the fractional flow reserve determination device.

[0047] The fractional flow reserve determination method provided in the embodiments of the present application can be applied to a fractional flow reserve determination device, which can be a device such as a smart terminal, a PC terminal, or a mobile terminal.

[0048] The following will be described in detail with reference to the accompanying drawings. In this embodiment, the execution entity is taken as an example of a fractional flow reserve determination device. It should be noted that the description order of the following embodiments does not limit the preferred order of the embodiments. Although the logical order is shown in the flowchart, in some cases, the steps shown or described may be executed in an order different from that shown in the drawings.

[0049] Please refer to Figure 1 , and a first embodiment of the fractional flow reserve determination method is proposed. The first embodiment includes the following steps:

[0050] Step 101: Obtain at least two-phase magnetic resonance medical images of a target blood vessel based on the time sequence;

[0051] Step 102: Determine the contrast agent change information in the target blood vessel based on the at least two-phase magnetic resonance medical images;

[0052] Step 103: Determine the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information.

[0053] In this embodiment, when performing a medical image examination on a patient, the fractional flow reserve determination device obtains at least two-phase magnetic resonance medical images of the patient's target blood vessel, and determines the contrast agent change information in the target blood vessel based on the at least two-phase magnetic resonance medical images; and determines the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information. It can be understood that at least two-phase magnetic resonance medical images can dynamically observe the influence of the target blood vessel on the flow of the contrast agent when the contrast agent flows through the target blood vessel. The target blood vessel is the blood vessel in the patient's lesion area.

[0054] It should be noted that the patient's lesion area may include the kidney area, the liver area, the heart area, the intestinal area, etc., which are not limited herein.

[0055] Specifically, each step will be described in detail as follows:

[0056] Step 101: Obtain at least two-phase magnetic resonance medical images of a target blood vessel based on the time sequence;

[0057] In this step, the fractional flow reserve determination device obtains at least two-phase magnetic resonance medical images of the target blood vessel based on the chronological order. Specifically, the doctor first inputs a contrast agent into the patient's body, and the fractional flow reserve determination device starts to collect magnetic resonance medical images of the target blood vessel. Among all the collected magnetic resonance medical images, at least two-phase magnetic resonance medical images before and after the contrast agent flows through the target blood vessel are obtained.

[0058] Step 102: Determine the contrast agent change information in the target blood vessel based on at least two-phase of the magnetic resonance medical images;

[0059] In this step, after obtaining at least two-phase magnetic resonance medical images, the fractional flow reserve determination device inputs the at least two-phase magnetic resonance medical images into a pre-established recognition model, and analyzes the at least two-phase magnetic resonance medical images through the recognition model to determine the contrast agent change information in the target blood vessel.

[0060] Exemplarily, the fractional flow reserve determination device can input two-phase magnetic resonance medical images into a pre-established recognition model. The two-phase magnetic resonance medical images are respectively the magnetic resonance medical images before and after the contrast agent flows through the target blood vessel. The fractional flow reserve determination device can input three-phase magnetic resonance medical images into a pre-established recognition model. The three-phase magnetic resonance medical images are respectively the magnetic resonance medical images before, during, and after the contrast agent flows through the target blood vessel. The fractional flow reserve determination device can input multiple-phase magnetic resonance medical images into a pre-established recognition model. The multiple-phase magnetic resonance medical images are respectively the magnetic resonance medical images before, during, and after the contrast agent flows through the target blood vessel.

[0061] Step 103: Determine the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information.

[0062] In this step, after the fractional flow reserve determination device analyzes at least two-phase magnetic resonance medical images through the recognition model to determine the contrast agent change information in the target blood vessel, it further determines the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information through the recognition model. Among them, the fractional flow reserve (FFR) is defined as the ratio of the maximum blood flow that the diseased blood vessel can provide to the maximum blood flow that the blood vessel can provide when it is completely normal.

[0063] The fractional flow reserve determination device of this embodiment obtains at least two-phase magnetic resonance medical images of a target blood vessel based on the time sequence; determines the contrast agent change information in the target blood vessel based on the at least two-phase magnetic resonance medical images; and determines the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information. Determining the contrast agent change information in the target blood vessel based on at least two-phase magnetic resonance medical images and then determining the fractional flow reserve corresponding to the target blood vessel according to the contrast agent change information can improve the accuracy of determining the fractional flow reserve.

[0064] Further, referring to Figure 2 , a second embodiment of the fractional flow reserve determination method is proposed. The difference between the second embodiment and the first embodiment is that the determining the contrast agent change information in the target blood vessel based on the at least two-phase magnetic resonance medical images includes:

[0065] Step 1021: Identify each phase of the magnetic resonance medical image respectively to determine the contrast agent distribution corresponding to each phase of the magnetic resonance medical image;

[0066] In this step, after obtaining at least two-phase magnetic resonance medical images, the fractional flow reserve determination device inputs the at least two-phase magnetic resonance medical images into a pre-established identification model, and the identification model identifies each phase of the magnetic resonance medical image respectively to determine the contrast agent distribution corresponding to each phase of the magnetic resonance medical image.

[0067] Specifically, after obtaining at least two-phase magnetic resonance medical images, the fractional flow reserve determination device first performs image preprocessing on each phase of the magnetic resonance medical image. The image preprocessing includes noise reduction and time registration; then inputs the preprocessed at least two-phase magnetic resonance medical images into the identification model, and the identification model estimates the contrast agent concentration of each phase of the magnetic resonance medical image respectively. Usually, the signal intensity is proportional to the concentration of the contrast agent in the blood vessel, so the concentration distribution of the contrast agent can be estimated by comparing the signal intensities of the images. Finally, the identification model dynamically analyzes to determine the contrast agent distribution corresponding to each phase of the magnetic resonance medical image.

[0068] In one embodiment, step 1021 may include steps 10211 to 10212, specifically:

[0069] Step 10211: For each phase of the magnetic resonance medical image, perform preprocessing on the magnetic resonance medical image to obtain a target magnetic resonance medical image;

[0070] In this step, for each phase of the magnetic resonance medical image, the fractional flow reserve determination device performs preprocessing on the magnetic resonance medical image to obtain a target magnetic resonance medical image. The preprocessing includes noise reduction and time registration.

[0071] Step 10212, obtain the pixel brightness value of each pixel point in the target magnetic resonance medical image, and determine the distribution of the contrast agent corresponding to the magnetic resonance medical image according to the pixel brightness value and a preset mapping relationship; the preset mapping relationship is the mapping relationship between the pixel brightness value and the contrast agent concentration.

[0072] In this step, the fractional flow reserve determination device inputs at least two preprocessed magnetic resonance medical images into the recognition model, obtains the pixel brightness value of each pixel point in each target magnetic resonance medical image through the recognition model, and determines the distribution of the contrast agent corresponding to the magnetic resonance medical image according to the pixel brightness value and the preset mapping relationship; the preset mapping relationship is the mapping relationship between the pixel brightness value and the contrast agent concentration. It can be understood that the contrast agent concentration affects the pixel brightness value of the pixel point in the magnetic resonance medical image. The greater the contrast agent concentration, the higher the pixel brightness value; the smaller the contrast agent concentration, the lower the pixel brightness value. Therefore, the distribution of the contrast agent can be determined according to the pixel brightness value.

[0073] Step 1022, compare the contrast agent distribution situations corresponding to at least two magnetic resonance medical images, and determine the contrast agent change information in the target blood vessel.

[0074] In this step, the fractional flow reserve determination device compares the contrast agent distribution situations corresponding to at least two magnetic resonance medical images through the recognition model, and determines the contrast agent change information in the target blood vessel.

[0075] In an embodiment, step 1022 may include step 10221 to step 10222, specifically:

[0076] Step 10221, use one of the magnetic resonance medical images as a reference image to register at least two magnetic resonance medical images.

[0077] In this step, after the fractional flow reserve determination device determines the contrast agent distribution situation of each magnetic resonance medical image through the recognition model, it uses one of the magnetic resonance medical images as a reference image to register at least two magnetic resonance medical images, so that the target blood vessels in each magnetic resonance medical image can be aligned with each other, which can improve the accuracy of subsequent analysis and comparison.

[0078] Step 10222, compare the contrast agent distribution situations corresponding to at least two registered magnetic resonance medical images, and determine the contrast agent change information in the target blood vessel.

[0079] In this step, the fractional flow reserve determination device compares the contrast agent distribution situations corresponding to at least two registered magnetic resonance medical images, and determines the contrast agent change information in the target blood vessel.

[0080] Exemplarily, the two-phase magnetic resonance medical images are respectively the magnetic resonance medical images before and after the contrast agent flows through the target blood vessel. The fractional flow reserve determination device compares the contrast agent distribution corresponding to the magnetic resonance medical image before the contrast agent flows through the target blood vessel after registration with the contrast agent distribution corresponding to the magnetic resonance medical image after the contrast agent flows through the target blood vessel, and thus can determine the contrast agent change information in the target blood vessel.

[0081] The fractional flow reserve determination device of this embodiment respectively identifies each phase of the magnetic resonance medical images to determine the contrast agent distribution corresponding to each phase of the magnetic resonance medical images; compares the contrast agent distributions corresponding to at least two phases of the magnetic resonance medical images to determine the contrast agent change information in the target blood vessel. By analyzing and comparing the contrast agent distributions corresponding to at least two phases of magnetic resonance medical images, the accuracy of determining the contrast agent change information in the target blood vessel is improved.

[0082] Further, referring to Figure 3 , a third embodiment of the fractional flow reserve determination method is proposed. Determining the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information includes:

[0083] Step 1031: Based on at least two phases of the magnetic resonance medical images, determine the vascular lesion region in the target blood vessel;

[0084] In this step, the fractional flow reserve determination device determines the vascular lesion region in the target blood vessel based on at least two phases of magnetic resonance medical images. Specifically, the fractional flow reserve determination device processes at least two phases of magnetic resonance medical images, and the vascular lesion region in the target blood vessel. Common blood vessel extraction methods include: Threshold segmentation: By setting a brightness threshold, the image is divided into a blood vessel region and a non-blood vessel region. This method is simple and effective, but has poor effects on complex or blurred images. Edge detection: Algorithms such as Canny edge detection and Sobel operator are used to identify the edges in the image, and then the blood vessel contour is extracted. Morphological operations: Morphological operations such as dilation and erosion are used to enhance or remove certain regions to help accurately extract the blood vessel structure. Graphical models and optimization algorithms: Active Contour models (such as Snake algorithms) or level set methods are used to automatically track the boundaries of blood vessels and optimize them.

[0085] Step 1032: Based on the contrast agent change information, as well as the blood vessel morphology change information and blood vessel blood flow change information corresponding to at least two phases of the magnetic resonance medical images, determine the reference blood flow information corresponding to the vascular lesion region;

[0086] In this step, the fractional flow reserve determination device processes the magnetic resonance medical images of each period, determines the blood vessel morphological change information and blood vessel blood flow change information corresponding to the magnetic resonance medical images of each period, and then determines the reference blood flow information corresponding to the blood vessel lesion area according to the contrast agent change information, blood vessel morphological change information and blood vessel blood flow change information corresponding to at least two periods of magnetic resonance medical images.

[0087] Exemplarily, the two periods of magnetic resonance medical images are respectively the magnetic resonance medical images before and after the contrast agent flows through the target blood vessel. The fractional flow reserve determination device determines the blood vessel morphological change information and blood vessel blood flow change information corresponding to the magnetic resonance medical images of each period, and then determines the reference blood flow information corresponding to the blood vessel lesion area according to the contrast agent change information, blood vessel morphological change information and blood vessel blood flow change information corresponding to the magnetic resonance medical image before the contrast agent flows through the target blood vessel, and the contrast agent change information, blood vessel morphological change information and blood vessel blood flow change information corresponding to the magnetic resonance medical image after the contrast agent flows through the target blood vessel.

[0088] Step 1033: Determine the fractional flow reserve corresponding to the target blood vessel according to the reference blood flow information.

[0089] In this step, the fractional flow reserve determination device determines the fractional flow reserve corresponding to the target blood vessel according to the reference blood flow information.

[0090] In an embodiment, the reference blood flow information includes the reference blood flow volume. Step 1033 may include steps 10331 to 10332. Specifically:

[0091] Step 10331: Obtain the target blood flow volume corresponding to the target blood vessel, where the target blood flow volume is the blood flow volume when there is no lesion in the target blood vessel.

[0092] In this step, the fractional flow reserve determination device obtains the target blood flow volume corresponding to the target blood vessel, and the target blood flow volume is the blood flow volume when there is no lesion in the target blood vessel. Specifically, the fractional flow reserve determination device stores in advance the blood flow volume when there is no lesion in the blood vessels of each part of the human body. When the fractional flow reserve determination device determines the target blood vessel, it can query and obtain the target blood flow volume corresponding to the target blood vessel in the pre-stored database.

[0093] Step 10332: Calculate the ratio of the reference blood flow volume to the target blood flow volume, and determine the fractional flow reserve corresponding to the target blood vessel.

[0094] In this step, after the fractional flow reserve determination device determines the reference blood flow volume and the target blood flow volume of the target blood vessel, it calculates the ratio of the reference blood flow volume to the target blood flow volume, and determines this ratio as the fractional flow reserve corresponding to the target blood vessel. Specifically, fractional flow reserve = reference blood flow volume / target blood flow volume.

[0095] The fractional flow reserve determination device of this embodiment determines the vascular lesion area in the target blood vessel based on at least two-phase magnetic resonance medical images; determines the reference blood flow information corresponding to the vascular lesion area based on the contrast agent change information, the vascular morphological change information, and the vascular blood flow change information corresponding to at least two-phase magnetic resonance medical images; and determines the fractional flow reserve corresponding to the target blood vessel according to the reference blood flow information. Determining the fractional flow reserve corresponding to the target blood vessel through image analysis avoids using invasive methods to determine the fractional flow reserve and can improve the accuracy of the determined fractional flow reserve.

[0096] Further, referring to Figure 4 , a fourth embodiment of the fractional flow reserve determination method is proposed. The difference between the fourth embodiment and the first to third embodiments is that the determining of the contrast agent change information in the target blood vessel based on at least two-phase magnetic resonance medical images includes:

[0097] Step a: Segment the blood vessel regions in at least two-phase magnetic resonance medical images to obtain the blood vessel region images corresponding to each phase of the magnetic resonance medical images;

[0098] In this step, the fractional flow reserve determination device segments the blood vessel regions in at least two-phase magnetic resonance medical images to obtain the blood vessel region images corresponding to each phase of the magnetic resonance medical images. Specifically, the fractional flow reserve determination device segments each phase of the magnetic resonance medical images through a pre-created segmentation model to obtain the blood vessel region images in each phase of the magnetic resonance medical images.

[0099] It can be understood that segmenting the blood vessel region images in the magnetic resonance medical images can reduce the influence of other regions except the blood vessel regions in the magnetic resonance medical images on subsequent analysis and can further improve the analysis accuracy of the subsequent contrast agent distribution.

[0100] Step b: Perform recognition processing on the blood vessel region images corresponding to each phase of the magnetic resonance medical images to determine the contrast agent distribution corresponding to each phase of the blood vessel region images;

[0101] In this step, after the fractional flow reserve determination device obtains the blood vessel region images corresponding to at least two-phase magnetic resonance medical images, it inputs the at least two-phase blood vessel region images into a pre-established recognition model, and the recognition model respectively recognizes each phase of the blood vessel region images to determine the contrast agent distribution corresponding to each phase of the blood vessel region images.

[0102] Specifically, after the fractional flow reserve determination device obtains the vascular region images corresponding to at least two phases of magnetic resonance medical images, it first performs image preprocessing on the vascular region images of each phase. The image preprocessing includes denoising and time registration. Then, it inputs the preprocessed vascular region images of at least two phases into the recognition model, and the recognition model estimates the contrast agent concentration of the vascular region images of each phase respectively. The signal intensity is usually proportional to the concentration of the contrast agent in the blood vessel, so the concentration distribution of the contrast agent can be estimated by comparing the signal intensities of the images. Finally, the recognition model dynamically analyzes to determine the contrast agent distribution corresponding to the vascular region images of each phase.

[0103] Step c: Compare the contrast agent distribution corresponding to the vascular region images of at least two phases to determine the contrast agent change information in the target blood vessel.

[0104] In this step, after the fractional flow reserve determination device determines the contrast agent distribution of the vascular region images of each phase through the recognition model, it uses one phase of the vascular region image as the reference image to register the vascular region images of at least two phases, so that the target blood vessels in the vascular region images of each phase can be aligned with each other, which can improve the accuracy of subsequent analysis and comparison. The fractional flow reserve determination device compares the contrast agent distribution corresponding to the registered vascular region images of at least two phases to determine the contrast agent change information in the target blood vessel.

[0105] The fractional flow reserve determination device in this embodiment segments the vascular regions in at least two phases of the magnetic resonance medical images to obtain the vascular region images corresponding to the magnetic resonance medical images of each phase; respectively performs recognition processing on the vascular region images corresponding to the magnetic resonance medical images of each phase to determine the contrast agent distribution corresponding to the vascular region images of each phase; compares the contrast agent distribution corresponding to the vascular region images of at least two phases to determine the contrast agent change information in the target blood vessel. Segmenting the vascular region images in the magnetic resonance medical images can reduce the influence of other regions except the vascular region in the magnetic resonance medical images on the subsequent analysis, further improve the accuracy of the subsequent analysis of the contrast agent distribution, and thus improve the accuracy of the determined contrast agent change information.

[0106] This embodiment also provides a fractional flow reserve determination device, which can be specifically integrated in fractional flow reserve determination devices such as smart terminals, PC terminals, and mobile terminals, as Figure 5 shown. The fractional flow reserve determination device may include:

[0107] An acquisition unit 1001, configured to acquire at least two phases of magnetic resonance medical images of a target blood vessel based on the time sequence;

[0108] The first determination unit 1002 is configured to determine the contrast agent change information in the target blood vessel based on the magnetic resonance medical images of at least two periods;

[0109] The second determination unit 1003 is configured to determine the fractional flow reserve corresponding to the target blood vessel based on the contrast agent change information.

[0110] In an optional example, the first determination unit is further configured to:

[0111] Identify each period of the magnetic resonance medical images respectively to determine the contrast agent distribution corresponding to each period of the magnetic resonance medical images;

[0112] Compare the contrast agent distributions corresponding to the magnetic resonance medical images of at least two periods to determine the contrast agent change information in the target blood vessel.

[0113] In an optional example, the first determination unit is further configured to:

[0114] For each period of the magnetic resonance medical images, preprocess the magnetic resonance medical images to obtain target magnetic resonance medical images;

[0115] Obtain the pixel brightness value of each pixel point in the target magnetic resonance medical image, and determine the contrast agent distribution corresponding to the magnetic resonance medical image according to the pixel brightness value and a preset mapping relationship; the preset mapping relationship is the mapping relationship between the pixel brightness value and the contrast agent concentration.

[0116] In an optional example, the first determination unit is further configured to:

[0117] Use one period of the magnetic resonance medical images as a reference image to register the magnetic resonance medical images of at least two periods;

[0118] Compare the contrast agent distributions corresponding to the registered magnetic resonance medical images of at least two periods to determine the contrast agent change information in the target blood vessel.

[0119] In an optional example, the second determination unit is further configured to:

[0120] Determine the vascular lesion area in the target blood vessel based on the magnetic resonance medical images of at least two periods;

[0121] Determine the reference blood flow information corresponding to the vascular lesion area based on the contrast agent change information, the vascular morphological change information and the vascular blood flow change information corresponding to the magnetic resonance medical images of at least two periods;

[0122] Determine the fractional flow reserve corresponding to the target blood vessel according to the reference blood flow information.

[0123] In an alternative example, the second determination unit is further configured to:

[0124] Obtain the target blood flow volume corresponding to the target blood vessel, where the target blood flow volume is the blood flow volume when there is no lesion in the target blood vessel;

[0125] Calculate the ratio of the reference blood flow volume to the target blood flow volume, and determine the fractional flow reserve corresponding to the target blood vessel.

[0126] In an alternative example, the first determination unit is further configured to:

[0127] Segment the blood vessel regions in at least two phases of the magnetic resonance medical images to obtain the blood vessel region images corresponding to each phase of the magnetic resonance medical images;

[0128] Perform recognition processing on the blood vessel region images corresponding to each phase of the magnetic resonance medical images respectively, and determine the contrast agent distribution corresponding to the blood vessel region images of each phase;

[0129] Compare the contrast agent distributions corresponding to the blood vessel region images of at least two phases to determine the contrast agent change information in the target blood vessel.

[0130] Adopting the solution of this embodiment, based on the time sequence, obtain at least two phases of magnetic resonance medical images of the target blood vessel; based on the at least two phases of magnetic resonance medical images, determine the contrast agent change information in the target blood vessel; based on the contrast agent change information, determine the fractional flow reserve corresponding to the target blood vessel. Determining the contrast agent change information in the target blood vessel based on at least two phases of magnetic resonance medical images, and then determining the fractional flow reserve corresponding to the target blood vessel according to the contrast agent change information can improve the accuracy of determining the fractional flow reserve.

[0131] Correspondingly, an embodiment of the present application further provides a fractional flow reserve determination device, as Figure 6 shown, Figure 6 is a schematic structural diagram of the fractional flow reserve determination device provided by the embodiment of the present application. The fractional flow reserve determination device 1100 includes a processor 1101 with one or more processing cores, a memory 1102 with one or more computer-readable storage media, and a computer program stored on the memory 1102 and executable on the processor. Among them, the processor 1101 is electrically connected to the memory 1102. Those skilled in the art can understand that the structural diagram of the fractional flow reserve determination device shown in the figure does not constitute a limitation on the fractional flow reserve determination device, and it may include more or fewer components than shown, or combine certain components, or have different component arrangements.

[0132] The processor 1101 is the control center of the fractional flow reserve determination device 1100, connecting various parts of the entire fractional flow reserve determination device 1100 through various interfaces and lines. By running or loading software programs and / or units stored in the memory 1102, and calling the data stored in the memory 1102, it executes various functions of the fractional flow reserve determination device 1100 and processes data, thereby monitoring the fractional flow reserve determination device 1100 as a whole. The processor 1101 can be a central processing unit (CPU), a graphics processing unit (GPU), a network processor (NP), etc., and can implement or execute the various methods, steps, and logic block diagrams disclosed in the embodiments of the present application.

[0133] In the embodiments of the present application, the processor 1101 in the fractional flow reserve determination device 1100 will load the instructions corresponding to the processes of one or more application programs into the memory 1102 according to the following steps, and the processor 1101 will run the application programs stored in the memory 1102 to implement various functions. For the specific implementation, reference can be made to the previous embodiments and will not be elaborated here.

[0134] Optionally, as Figure 6 shown, the fractional flow reserve determination device 1100 further includes: a touch display screen 1103, a radio frequency circuit 1104, an audio circuit 1105, an input unit 1106, and a power supply 1107. Among them, the processor 1101 is electrically connected to the touch display screen 1103, the radio frequency circuit 1104, the audio circuit 1105, the input unit 1106, and the power supply 1107 respectively. Those skilled in the art can understand that Figure 6 the structure of the fractional flow reserve determination device shown in

[0135] The touch display screen 1103 can be used to display a graphical user interface and receive operation instructions generated by a user acting on the graphical user interface. The touch display screen 1103 may include a display panel and a touch panel. Among them, the display panel can be used to display information input by the user or information provided to the user, as well as various graphical user interfaces of the fractional flow reserve determination device. These graphical user interfaces can be composed of graphics, text, icons, videos, and any combination thereof. Optionally, the display panel can be configured in the form of a liquid crystal display (LCD), an organic light-emitting diode (OLED), etc. The touch panel can be used to collect touch operations of the user on or near it (such as operations of the user using any suitable object or accessory such as a finger or a stylus on or near the touch panel), and generate corresponding operation instructions, and the operation instructions execute the corresponding program. Optionally, the touch panel can include two parts: a touch detection device and a touch controller. Among them, the touch detection device detects the touch position of the user and detects the signal brought by the touch operation, and transmits the signal to the touch controller; the touch controller receives the touch information from the touch detection device, converts it into contact coordinates, and then sends it to the processor 1101, and can receive and execute the commands sent by the processor 1101. The touch panel can cover the display panel. When the touch panel detects a touch operation on or near it, it is transmitted to the processor 1101 to determine the type of touch event. Subsequently, the processor 1101 provides a corresponding visual output on the display panel according to the type of touch event. In the embodiments of the present application, the touch panel and the display panel can be integrated into the touch display screen 1103 to implement input and output functions. However, in some embodiments, the touch panel and the touch panel can be implemented as two independent components to implement input and output functions. That is, the touch display screen 1103 can also be used as part of the input unit 1106 to implement the input function.

[0136] The radio frequency circuit 1104 can be used to transmit and receive radio frequency signals to establish wireless communication with a network device or other fractional flow reserve determination devices through wireless communication, and transmit and receive signals with the network device or other fractional flow reserve determination devices.

[0137] The audio circuit 1105 can be used to provide an audio interface between the user and the fractional flow reserve determination device through a speaker and a microphone. The audio circuit 1105 can convert the received audio data into an electrical signal and transmit it to the speaker, which converts it into a sound signal for output. On the other hand, the microphone converts the collected sound signal into an electrical signal, which is received by the audio circuit 1105, converted into audio data, and then the audio data is output to the processor 1101 for processing. After that, it is sent through the radio frequency circuit 1104 to, for example, another fractional flow reserve determination device, or the audio data is output to the memory 1102 for further processing. The audio circuit 1105 may also include an earphone jack to provide communication between the peripheral earphone and the fractional flow reserve determination device.

[0138] The input unit 1106 can be used to receive input digital, character information or user characteristic information (such as fingerprint, iris, facial information, etc.), and generate keyboard, mouse, joystick, optical or trackball signal inputs related to user settings and function controls.

[0139] The power supply 1107 is used to supply power to each component of the fractional flow reserve determination device 1100. Optionally, the power supply 1107 can be logically connected to the processor 1101 through a power management device, so as to implement functions such as management of charging, discharging, and power consumption management through the power management device. The power supply 1107 may also include any components such as one or more DC or AC power supplies, recharge devices, power failure detection circuits, power converters or inverters, and power status indicators.

[0140] Although Figure 6 not shown in the figure, the fractional flow reserve determination device 1100 may also include a camera, a sensor, a Wi-Fi module, a Bluetooth module, etc., which will not be elaborated here.

[0141] In the above embodiments, the descriptions of each embodiment have their own focuses. For the parts not detailed in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0142] Those of ordinary skill in the art can understand that all or part of the steps in the various methods of the above embodiments can be completed through instructions, or through instructions to control relevant hardware. The instructions can be stored in a computer-readable storage medium and loaded and executed by a processor.

[0143] Therefore, an embodiment of the present application provides a computer-readable storage medium, in which multiple computer programs are stored. The computer programs can be loaded by a processor to execute any one of the fractional flow reserve determination methods provided by the embodiments of the present application. The computer programs can execute the fractional flow reserve determination method. For specific implementation, reference can be made to the previous embodiments, which will not be elaborated here.

[0144] Among them, the computer-readable storage medium may include: read-only memory (ROM, Read Only Memory), random access memory (RAM, Random Access Memory), magnetic disk, optical disc, etc.

[0145] Since the computer program stored in the computer-readable storage medium can execute any one of the blood flow reserve fraction determination methods provided in the embodiments of the present application, the beneficial effects achievable by any one of the blood flow reserve fraction determination methods provided in the embodiments of the present application can be realized. For details, refer to the previous embodiments and will not be elaborated herein.

[0146] According to one aspect of the present application, there is also provided a computer program product or computer program. The computer program product or computer program includes computer instructions, and the computer instructions are stored in a computer-readable storage medium. The processor of the blood flow reserve fraction determination device reads the computer instructions from the computer-readable storage medium, and the processor executes the computer instructions, so that the blood flow reserve fraction determination device executes the methods provided in the various alternative implementations in the above embodiments.

[0147] In the above embodiments of the blood flow reserve fraction determination device, computer-readable storage medium, blood flow reserve fraction determination device, and computer program product, the descriptions of each embodiment have their own focuses. For the parts not detailed in a certain embodiment, reference may be made to the relevant descriptions of other embodiments. Those skilled in the art can clearly understand that for the convenience and conciseness of description, the specific working processes and beneficial effects brought by the above-described blood flow reserve fraction determination device, computer-readable storage medium, computer program product, blood flow reserve fraction determination device, and their corresponding units can refer to the description of the blood flow reserve fraction determination method in the above embodiments, and will not be elaborated herein specifically.

[0148] The above has introduced in detail a blood flow reserve fraction determination method, device, electronic device, readable storage medium, and computer program product provided by the embodiments of the present application. Specific examples are used in this article to elaborate on the principle and implementation manner of the present application. The description of the above embodiments is only used to help understand the method and its core idea of the present application; at the same time, for those skilled in the art, based on the idea of the present application, there will be changes in the specific implementation manner and application scope. In summary, the content of this specification should not be construed as a limitation to the present application.

Claims

1. A method for determining blood flow reserve fraction, characterized in that: The method for determining the blood flow reserve fraction comprises: Acquire at least two phases of magnetic resonance medical images of the target blood vessel based on a time sequence; Determining contrast agent change information in the target blood vessel based on at least two phases of the magnetic resonance medical images; Based on the contrast agent change information, a blood flow reserve fraction corresponding to the target blood vessel is determined.

2. The method for determining blood flow reserve fraction according to claim 1, characterized in that: The step of determining contrast agent change information in the target blood vessel based on at least two phases of magnetic resonance medical images includes: Respectively identifying the magnetic resonance medical images of each period, and determining the contrast agent distribution corresponding to the magnetic resonance medical images of each period; The contrast agent distribution conditions corresponding to the magnetic resonance medical images of at least two phases are compared to determine contrast agent change information in the target blood vessel.

3. The method for determining blood flow reserve fraction according to claim 2, characterized in that: The step of respectively identifying the magnetic resonance medical images of each period and determining the contrast agent distribution corresponding to the magnetic resonance medical images of each period includes: For each period of the magnetic resonance medical images, preprocessing the magnetic resonance medical images to obtain target magnetic resonance medical images; Obtain a pixel brightness value of each pixel in the target magnetic resonance medical image, and determine the contrast agent distribution corresponding to the magnetic resonance medical image based on the pixel brightness value and a preset mapping relationship; the preset mapping relationship is a mapping relationship between the pixel brightness value and the contrast agent concentration.

4. The method for determining blood flow reserve fraction according to claim 2, characterized in that: The step of comparing the contrast agent distribution conditions corresponding to the magnetic resonance medical images of at least two phases to determine the contrast agent change information in the target blood vessel includes: Using the magnetic resonance medical images of one phase as a reference image, registering the magnetic resonance medical images of at least two phases; The contrast agent distribution conditions corresponding to the registered magnetic resonance medical images of at least two phases are compared to determine contrast agent change information in the target blood vessel.

5. The method for determining blood flow reserve fraction according to claim 1, characterized in that: The determining of the blood flow reserve fraction corresponding to the target blood vessel based on the contrast agent change information includes: Determining a vascular lesion area in the target blood vessel based on at least two phases of the magnetic resonance medical images; Determine reference blood flow information corresponding to the vascular lesion area based on the contrast agent change information and the vascular morphology change information and vascular blood flow change information corresponding to the magnetic resonance medical images of at least two phases; A blood flow reserve fraction corresponding to the target blood vessel is determined according to the reference blood flow information.

6. The method for determining blood flow reserve fraction according to claim 5, characterized in that: The reference blood flow information includes a reference blood flow rate, and determining the blood flow reserve fraction corresponding to the target blood vessel according to the reference blood flow information includes: Acquiring a target blood flow corresponding to the target blood vessel, wherein the target blood flow is the blood flow when no lesion exists in the target blood vessel; The ratio of the reference blood flow rate to the target blood flow rate is calculated to determine the blood flow reserve fraction corresponding to the target blood vessel.

7. The method for determining blood flow reserve fraction according to claim 1, characterized in that: The step of determining contrast agent change information in the target blood vessel based on at least two phases of magnetic resonance medical images includes: Segmenting the blood vessel regions in the magnetic resonance medical images of at least two phases to obtain blood vessel region images corresponding to the magnetic resonance medical images of each phase; Respectively identifying and processing the blood vessel region images corresponding to the magnetic resonance medical images of each period to determine the distribution of contrast agents corresponding to the blood vessel region images of each period; The contrast agent distribution conditions corresponding to the blood vessel region images of at least two phases are compared to determine contrast agent change information in the target blood vessel.

8. A device for determining blood flow reserve fraction, characterized in that: The blood flow reserve fraction determination device comprises: An acquisition unit, configured to acquire at least two phases of magnetic resonance medical images of the target blood vessel based on a time sequence; A first determining unit, configured to determine contrast agent change information in the target blood vessel based on at least two phases of the magnetic resonance medical images; The second determining unit is configured to determine a blood flow reserve fraction corresponding to the target blood vessel based on the contrast agent change information.

9. An electronic device, characterized in that: The method comprises a processor and a memory, wherein the memory stores a computer program; the processor loads the computer program from the memory to execute the steps of the method for determining the blood flow reserve fraction according to any one of claims 1 to 7.

10. A computer-readable storage medium, characterized in that: The computer-readable storage medium stores a computer program, and the computer program is suitable for being loaded by a processor to execute the steps of the method for determining blood flow reserve fraction according to any one of claims 1 to 7.

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