Tumor gene detection sampling device
By designing a tumor gene detection sampling device that automates the release and mixing of mixed fluids, the risks of increased external contamination, sample residues and manual operation in the prior art are solved, and higher detection accuracy and operation convenience are achieved.
Patent Information
- Application Number
- CN202510288571.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-12
- Publication Date
- 2025-05-30
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing tumor gene detection sampling device has problems such as external contamination risk during saliva collection, sample residues lead to deviations in detection results, and manual addition of mixed liquid increases operational burden and contamination risk.
A sampling device including a gripping assembly and a release assembly is designed to reduce manual operation, reduce contamination risk, and improve sample collection accuracy and efficiency by automated mixing of the mixture.
The automatic release and mixing of mixed liquids is achieved, which reduces biosafety risks, simplifies operating steps, improves the accuracy and reliability of test results, and enhances the applicability and flexibility of the device.
Smart Images
Figure CN120052968A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of medical devices, and particularly to a tumor gene detection sampling device. Background Art
[0002] The main purpose of saliva biopsy is to explore the change characteristics of protein content and the alteration of nucleic acid molecular genetic information to understand the differences between the normal and tumor states of the body. Saliva is a clear, transparent and slightly acidic body fluid, and a normal person can secrete 1.0 - 1.5 L per day. The salivary gland has high permeability and is surrounded by rich capillaries, which enables the free exchange of molecules between the blood and the molecules in the adjacent salivary gland cells. Therefore, saliva not only contains the same proteins as blood, such as enzymes, hormones, antibodies and growth factors, but also includes genetic information such as mRNA, miRNA and DNA, and the expression levels of these substances in saliva and blood are closely related.
[0003] Compared with blood, saliva biopsy has unique advantages, such as convenient sampling, non-invasive and avoidable blood-borne infections. It was previously believed that due to the special anatomical location, saliva biopsy only has diagnostic value for head and neck tumors (such as oral cancer), but more and more experiments have confirmed that it can also be applied to tumors in the distal part of the body (such as pancreatic cancer, lung cancer, breast cancer, liver cancer). Thus, it can be seen that saliva biopsy is not restricted by the spatial location of tumors. Moreover, the changes of proteins and nucleic acids during the occurrence and development of tumors can be monitored in real time by saliva biopsy, without being restricted by the progression time of tumors. This study takes the tumor markers found in saliva as clues, summarizes the research status of saliva biopsy in the field of tumors from two aspects of detection technology and clinical application, and prospects its development prospects and challenges.
[0004] In current tumor gene detection sampling devices, especially those for saliva sampling, there are multiple significant technical problems that directly affect the quality of sample collection, the convenience of operation, and the accuracy of test results: Existing sampling devices usually include a sampling tube and a funnel, but the connection between these two parts often relies on manual replacement or assembly, which is extremely likely to introduce external pollution sources; During saliva collection, due to design defects of the sampling tube or improper user operation, saliva samples may remain on the side wall of the sampling tube or inside the funnel and cannot completely flow to the bottom of the sampling tube. This may cause deviations in test results due to the dilution effect of the residual sample or cross - contamination with other substances; To maintain the stability and integrity of saliva samples, a certain amount of mixed solution (such as DNA stabilizing solution) usually needs to be added to the sampling tube after saliva collection. However, most existing sampling devices require users to manually complete this step. This not only increases the operation burden on users but also may lead to problems such as inaccurate addition amount and uneven mixing. Excessive addition amount may dilute the sample and reduce the detection sensitivity; Too little addition amount may not effectively protect the DNA molecules in the sample, resulting in degradation or loss. In addition, manual addition is prone to introducing new pollution sources, further affecting the accuracy of test results.
[0005] To solve the above problems, the present invention proposes an innovative tumor gene detection sampling device. Summary of the Invention
[0006] To solve the above problems, the present invention provides a tumor gene detection sampling device. By designing a unique holding component and a release component, it realizes the automatic mixing of the mixed solution and the automatic release function of the funnel, reduces the biosafety risk, simplifies the operation steps, improves the convenience of cleaning and disinfection, and enhances the applicability and flexibility of the device.
[0007] To achieve the above purpose, the technical solution of the present invention is as follows: A tumor gene detection sampling device includes a sampling tube and a funnel. The sampling tube and the funnel are detachably connected. A holding component for grasping and a release component for releasing the mixed solution are installed between the sampling tube and the funnel. A liquid storage cavity is installed on the outer wall of the funnel. An outlet is provided at the bottom of the liquid storage cavity, and a nozzle is installed at the outlet.
[0008] The release component includes a first energy storage member. A first installation cavity is provided on the side wall of the sampling tube. A plurality of first fixing plates are fixedly connected to the side wall of the installation cavity along the circumference of the sampling tube. First sliding grooves are formed at the tops of the first fixing plates. First baffles are slidably engaged with the first sliding grooves. One end of the first energy storage member is fixedly connected to the inner side wall of the installation cavity. The other end of the first energy storage member is fixedly connected to a first rotating plate. A first notch matching the first sliding groove is formed on the first rotating plate. The first notch is slidably engaged with the side of the first baffle away from the first sliding groove. A first protrusion is provided on the side wall of the first rotating plate. A first circular hole matching the first protrusion is formed on the side wall of the installation cavity. A first wedge block is provided inside the holding component, and the first wedge block matches the first circular hole.
[0009] The technical principle of the above solution is as follows: The design of the holding component enables the patient to stably hold the entire sampling device, keeping the sampling tube vertical during the sampling process to avoid sample contamination. The first wedge block provided inside the holding component, through cooperation with the first circular hole and the first protrusion on the sampling tube, realizes the trigger control of the release component. The release component is powered by the first energy storage member. When the sample volume in the sampling tube reaches the predetermined standard, the sampling tube moves downward under the action of the sample weight. At this time, the first wedge block in the holding component aligns with and inserts into the first circular hole on the sampling tube, pushing the first protrusion, and then triggering the first energy storage member to release energy. The release of the first energy storage member causes the first rotating plate to rotate. The first notch on the first rotating plate drives the first baffle to slide in the first sliding groove, thereby realizing the extrusion of the liquid storage cavity. The liquid storage cavity is installed on the outer side wall of the funnel, and its bottom is provided with a liquid outlet and a spray head installed. This design enables the mixed liquid in the liquid storage cavity to be precisely and evenly sprayed into the sampling tube through the spray head to be mixed with the saliva sample.
[0010] The following beneficial effects can be obtained by adopting the above solution:
[0011] 1. In this solution, through the design of a unique release component, the automatic release of the mixed liquid is realized. When it is necessary to mix the sample and the reagent, the patient does not need to manually shake or stir, but operates the first wedge block in the holding component to make it match the first circular hole and push the first rotating plate to rotate. During this process, the first notch on the first rotating plate drives the first baffle to slide in the first sliding groove, thereby changing the spatial structure inside the sampling tube and promoting the mixing of the sample and the reagent. After the mixing is completed, by further operating the release component, the mixed liquid can be conveniently released for subsequent detection, greatly improving the operation convenience and efficiency.
[0012] 2. In this solution, the detachable connection design between the sampling tube and the funnel enables the device to be easily separated after use, facilitating thorough cleaning and disinfection of each component, effectively preventing the risk of cross-contamination. In addition, the setting of the liquid storage cavity and the spray head also facilitates replacement and cleaning, further ensuring the accuracy and reliability of the detection results.
[0013] 3. In this solution, when the traditional sampling device mixes the sample and the reagent, the patient may need to directly contact the sample or the reagent, which poses a certain biosafety risk. However, this device reduces the direct contact between the patient and the sample or the reagent through its automated mixing and releasing functions, thereby reducing the biosafety risk during the operation. At the same time, the design of the holding component also takes into account the comfort of the patient during use, reducing the hand fatigue that may be caused by long-term operation.
[0014] 4. In this solution, through precise mechanical structure design, such as the close cooperation of components like the first chute, the first baffle, and the first rotating plate, the uniformity and consistency of the mixing process are ensured, thereby improving the accuracy and repeatability of the detection results. This is of great significance for medical detections with high-precision requirements such as tumor gene detection.
[0015] 5. This solution is not only applicable to the sampling of tumor gene detection, but can also be appropriately modified and adjusted according to needs to adapt to the detection requirements of other types of biological samples. This flexibility and adaptability make this device have broad application prospects in the fields of biomedical research, clinical diagnosis, etc.
[0016] Furthermore, a sealing component for closing the sampling tube is installed in the sampling tube. The sealing component is located below the releasing component. The sealing component includes a second energy storage member. A second installation cavity is provided on the side wall of the sampling tube. A plurality of second fixing plates are fixedly connected to the side wall of the installation cavity along the circumference of the sampling tube. Second chutes are opened at the tops of the second fixing plates. Second baffles are slidably engaged with the second chutes. One end of the second energy storage member is fixedly connected to the inner side wall of the installation cavity, and the other end of the second energy storage member is fixedly connected to a second rotating plate. A second notch matching the second chute is opened on the second rotating plate. The second notch is slidably engaged with the side of the second baffle away from the second chute. A second protrusion is provided on the side wall of the second rotating plate, and a second round hole matching the second protrusion is opened on the side wall of the installation cavity. A second wedge block is provided in the holding component, and the second wedge block matches the second round hole.
[0017] Beneficial effects: The design of the sealing component enables the sampling tube to maintain a high degree of sealing after sampling. Through the precise cooperation of the second energy storage member, the second rotating plate, the second baffle, and the like, the patient can easily control the opening and closing of the sampling tube. When the second wedge block matches the second round hole and pushes the second rotating plate to rotate, the second notch will drive the second baffle to slide in the second chute, thereby opening or closing the sampling tube. This design ensures the sealing of the sampling tube during transportation, storage, or when it is not in use, effectively preventing the contamination or volatilization of the sample. The addition of the sealing component further improves the safety of the operation. During sampling or mixing, since the sampling tube is firmly closed, the patient does not need to worry about the accidental leakage of the sample, thereby reducing the biosafety risk. In addition, the sealing component also plays a role in preventing external impurities from entering the sampling tube, ensuring the purity of the sample and the accuracy of the detection results.
[0018] Furthermore, the cross-section of the liquid storage cavity is an inverted trapezoidal structure, the side walls of the liquid storage cavity are made of elastic material, and the nozzles at the bottom of the liquid storage cavity all face the side wall of the sampling tube.
[0019] Beneficial effects: The inverted trapezoidal structure of the liquid storage cavity enables the mixed liquid to be more effectively pushed towards the sampling tube during the extrusion or release process. At the same time, the elastic side walls can deform when being squeezed, further promoting the uniform mixing of the mixed liquid. When it is necessary to release the mixed liquid, since the nozzles at the bottom of the liquid storage cavity all face the side wall of the sampling tube, the mixed liquid can be sprayed into the sampling tube more directly and quickly. This design reduces the resistance of the mixed liquid during the release process, improves the release efficiency, and ensures that the mixed liquid can fully cover the sample area inside the sampling tube. The cooperation of the inverted trapezoidal structure and the elastic side walls enables the liquid storage cavity to more easily return to its original state after releasing the mixed liquid, reducing the residue of the mixed liquid in the liquid storage cavity. At the same time, since the nozzles face the side wall of the sampling tube, the mixed liquid can be released more thoroughly, reducing the risk of waste and pollution.
[0020] Furthermore, guiding grooves are provided on the outer side wall of the liquid storage cavity, and one end of the first baffle away from the first sliding groove is slidably engaged with the guiding grooves.
[0021] Beneficial effects: The guiding grooves provide a clear trajectory and support for the movement of the first baffle, making the first baffle more stable during the sliding process and not prone to deviation or shaking. This stability not only ensures the precise control of the internal structure of the sampling tube but also extends the service life of the device and reduces the failures caused by component loosening or wear. At the same time, when releasing the mixed liquid, the guiding function of the guiding grooves can ensure that the first baffle moves along the predetermined trajectory, enabling the mixed liquid to flow out smoothly, improving the release efficiency and accuracy. The smooth surface of the guiding grooves reduces the frictional resistance of the first baffle during the sliding process, reducing the wear between components. This not only helps to maintain the precision and performance of the device but also reduces the risk of sample contamination caused by impurities generated by wear.
[0022] Furthermore, the holding assembly includes a housing, a first wedge block and a second wedge block are fixedly connected to the inner side wall of the housing from top to bottom in sequence, and a limiting assembly for preventing the sampling tube from falling is installed at the bottom of the housing.
[0023] Beneficial effects: The housing design of the gripping assembly provides a firm and comfortable gripping point for the patient, enabling the patient to more conveniently operate the entire sampling device. The fixed connection of the first wedge block and the second wedge block inside the housing ensures that they can move synchronously and stably, thus simplifying the operation process and improving the operation efficiency. The presence of the housing not only provides support for the first wedge block and the second wedge block, but also enhances the structural stability of the entire gripping assembly. This stability helps to reduce errors and failures caused by component loosening or deformation during operation, and improves the reliability and durability of the sampling device. The limit assembly installed at the bottom of the housing is an important safety design. It can effectively prevent the sampling tube from accidentally falling or slipping out when the patient operates the sampling device. This design not only protects the integrity of the sampling tube and the sample inside it, but also avoids the risk of contamination or damage caused by the falling of the sampling tube.
[0024] Furthermore, the limit assembly includes a circular ring and sliders. The circular ring is fixedly connected to the inner side wall of the bottom of the housing. Special-shaped sliding grooves are provided on both sides of the inner side wall of the housing. One end of each special-shaped sliding groove penetrates through the circular ring, and the sliders are slidably engaged with the special-shaped sliding grooves. The sides of the sliders away from the special-shaped sliding grooves are fixedly connected to the outer side walls on both sides of the sampling tube.
[0025] Beneficial effects: The fixed connection between the circular ring and the inner side wall of the bottom of the housing forms a stable support structure. The sliding fit of the sliders in the special-shaped sliding grooves ensures the stability and safety of the sampling tube during movement. This design effectively prevents the sampling tube from accidentally falling or shifting during operation, protecting the integrity and safety of the sample. The design of the special-shaped sliding grooves provides an accurate guiding path for the sliders, enabling the sampling tube to move along a predetermined trajectory when moving. This accurate guiding not only improves the operation accuracy, but also reduces errors and failures caused by improper operation. At the same time, the fixed connection between the sliders and the outer side walls on both sides of the sampling tube ensures the stability of the sampling tube during movement and prevents it from shaking or rotating in the sliding grooves.
[0026] Furthermore, gripping parts are provided on both sides of the outer side wall of the housing, and anti-slip patterns are fixedly connected to the gripping parts.
[0027] Beneficial effects: The provision of the gripping parts provides a more ergonomic gripping position for the patient, enabling the patient to grip the sampling device more comfortably when operating. This design reduces hand fatigue and improves the comfort during long-term operation. The addition of the anti-slip patterns significantly enhances the anti-slip performance of the gripping parts. Under conditions such as wet, greasy or when wearing gloves, the anti-slip patterns can increase the friction between the hand and the gripping parts, preventing the sampling device from falling or operating errors caused by hand slipping. This design improves the safety and stability of the operation.
[0028] Furthermore, a notch is provided on the side wall of the funnel, and a baffle passes through the notch. One end of the baffle located outside the funnel is fixedly connected to a third energy storage member, one end of the third energy storage member is fixedly connected to the outer wall of the funnel, and the baffle is embedded in the top of the liquid storage cavity and is movably matched.
[0029] Beneficial effects: When the weight of the saliva sample causes the sampling tube to move downward and then squeeze the liquid storage cavity, the baffle at the top of the liquid storage cavity will pop out due to compressive deformation. During this process, the restoring force of the third spring is released, pulling the baffle outside the funnel upward. Due to the principle of the lever structure, the baffle inside the funnel will correspondingly press downwards to achieve automatic sealing of the funnel. This design effectively prevents the saliva sample from entering the sampling tube again during the sampling process, ensuring the accuracy and reliability of sampling.
[0030] Furthermore, a spiral liquid flow groove is provided on the inner side wall of the sampling tube, and the liquid flow groove extends from the bottom of the sampling tube to the top of the sampling tube.
[0031] Beneficial effects: The design of the spiral liquid flow groove enables the mixed liquid to form a spiral flow in the sampling tube, thereby more effectively mixing with the saliva sample and improving the mixing efficiency. The scouring effect generated by the spiral flow helps to remove the residual sample on the inner side wall of the sampling tube, ensuring the total amount and accuracy of the sample. The spiral groove increases the surface area of the inner side wall of the sampling tube, providing more contact area for the sample and the mixed liquid. This design helps to enhance the stability of the sample and prevent the sample from stratifying or precipitating during the mixing process.
[0032] Furthermore, the sampling tube is made of a transparent material, and scale lines are provided on the side wall of the sampling tube.
[0033] Beneficial effects: The transparent material enables the patient to directly observe the sample volume in the sampling tube, allowing for quick inspection without opening or disassembling the sampling tube. This is particularly important for application scenarios that require precise control of the sample volume, such as medical testing, scientific research experiments, etc. The setting of the scale lines provides a clear reference standard for the patient, enabling the patient to more accurately control the sampling volume. By reading the values on the scale lines, the patient can ensure that each sampling reaches the predetermined sample volume requirement, thereby improving the accuracy and reliability of sampling.
[0034] Additional aspects and advantages of the present invention will be given in part in the following description, become apparent in part from the following description, or be learned through the practice of the present invention. Description of the Drawings
[0035] Figure 1 Is an axonometric view of an embodiment of the tumor gene detection sampling device of the present invention;
[0036] Figure 2 is Figure 1 a cross-sectional view taken along the A-A direction in
[0037] Figure 3 is Figure 1 A cross-sectional view in the B-B direction in
[0038] Figure 4 is Figure 1 A cross-sectional view in the C-C direction in
[0039] Figure 5 A cross-sectional view of the funnel in the embodiment of the tumor gene detection sampling device of the present invention;
[0040] Figure 6 A cross-sectional view of the holding assembly in the embodiment of the tumor gene detection sampling device of the present invention.
[0041] Reference numerals in the accompanying drawings of the specification include: 1, sampling tube; 2, funnel; 3, housing; 4, first spring; 5, first fixing plate; 6, first chute; 7, first baffle; 8, first rotating plate; 9, first notch; 10, first protrusion; 11, second spring; 12, second fixing plate; 13, second chute; 14, second baffle; 15, second rotating plate; 16, second notch; 17, second protrusion; 101, first installation cavity; 102, second installation cavity; 103, first round hole; 104, second round hole; 201, liquid storage cavity; 202, spray head; 301, first wedge block; 302, second wedge block; 303, ring; 304, special-shaped chute. Detailed implementation manners
[0042] Next, the technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.
[0043] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be construed as a limitation of the present invention. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.
[0044] In the description of the present invention, it should be noted that unless otherwise clearly specified and defined, the terms "installation", "connection", and "coupling" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.
[0045] The following is a further detailed description through specific embodiments:
[0046] Embodiment 1:
[0047] As shown in the Figures 1-5 accompanying drawings: A tumor gene detection sampling device includes a sampling tube 1 and a funnel 2. The sampling tube 1 and the funnel 2 are detachably connected. The sampling tube 1 is made of a transparent material, and a scale line is provided on the side wall of the sampling tube 1. A holding assembly for grasping and a releasing assembly for releasing the mixed liquid are installed between the sampling tube 1 and the funnel 2. A liquid storage cavity 201 is installed on the outer side wall of the funnel 2. An outlet is provided at the bottom of the liquid storage cavity 201, and a spray head 202 is installed at the outlet; the cross-section of the liquid storage cavity 201 is an inverted trapezoidal structure, the side wall of the liquid storage cavity 201 is made of an elastic material, and the spray heads 202 at the bottom of the liquid storage cavity 201 all face the side wall of the sampling tube 1.
[0048] The releasing assembly includes a first energy storage member. In this embodiment, the first energy storage member is a first spring 4. A first installation cavity 101 is provided on the side wall of the sampling tube 1. A plurality of first fixing plates 5 are fixedly connected along the circumference of the sampling tube 1 on the side wall of the installation cavity. First sliding grooves 6 are opened at the tops of the first fixing plates 5. First baffles 7 are slidably engaged with the first sliding grooves 6. One end of the first energy storage member is fixedly connected to the inner side wall of the installation cavity, and the other end of the first energy storage member is fixedly connected to a first rotating plate 8. A first notch 9 matching the first sliding groove 6 is opened on the first rotating plate 8. The first notch 9 is slidably engaged with the side of the first baffle 7 away from the first sliding groove 6. A first protrusion 10 is provided on the side wall of the first rotating plate 8, and a first circular hole 103 matching the first protrusion 10 is opened on the side wall of the installation cavity. A first wedge block 301 is provided in the holding assembly, and the first wedge block 301 is matched with the first circular hole 103. A guiding groove is provided on the outer side wall of the liquid storage cavity 201, and the end of the first baffle 7 away from the first sliding groove 6 is slidably engaged with the guiding groove.
[0049] A sealing assembly for closing the sampling tube 1 is installed in the sampling tube 1. The sealing assembly is located below the release assembly. The sealing assembly includes a second energy storage member. In this embodiment, the second energy storage member is the second spring 11. A second installation cavity 102 is provided on the side wall of the sampling tube 1. A plurality of second fixing plates 12 are fixedly connected to the side wall of the installation cavity along the circumference of the sampling tube 1. Second chutes 13 are provided at the tops of the second fixing plates 12. Second baffles 14 are slidably engaged with the second chutes 13. One end of the second energy storage member is fixedly connected to the inner side wall of the installation cavity, and the other end of the second energy storage member is fixedly connected to a second rotating plate 15. A second notch 16 matching the second chute 13 is provided on the second rotating plate 15. The second notch 16 is slidably engaged with the side of the second baffle 14 away from the second chute 13. A second protrusion 17 is provided on the side wall of the second rotating plate 15. A second round hole 104 matching the second protrusion 17 is provided on the side wall of the installation cavity. A second wedge block 302 is provided in the holding assembly. The second wedge block 302 matches the second round hole 104. The holding assembly includes a housing 3. The first wedge block 301 and the second wedge block 302 are integrally formed on the inner side wall of the housing 3 from top to bottom.
[0050] The specific implementation process is as follows:
[0051] Preparation stage: Confirm that all components of the sampling device are intact, especially the sampling tube 1, the funnel 2, the holding assembly and the release assembly. Check whether the first spring 4 and the second spring 11 are in an appropriate tensile energy storage state. Ensure that the scale line on the sampling tube 1 is clearly visible for accurately judging the sample volume.
[0052] Patient preparation: 30 minutes before collecting the saliva sample, the patient uses drinking water to clean the oral cavity to remove food residues and other impurities that may affect the sample quality. Press the tip of the tongue against the upper or lower jaw tooth roots to help enrich saliva by this method.
[0053] Sampling operation: The patient holds the housing 3 of the holding assembly to ensure that the sampling tube 1 remains vertical. The patient gently spits the saliva sample into the funnel 2. The sample volume can be observed through the scale line in the sampling tube 1 until the liquid saliva (without bubbles) reaches the standard volume (such as the 2 ml scale line). When the liquid in the sampling tube 1 reaches the standard volume, the weight of the saliva sample causes the sampling tube 1 to move downward in the housing 3. The first wedge block 301 moves down with the sampling tube 1 and inserts into the first round hole 103, pushing out the first protrusion 10 in the first round hole 103. Due to the restoring force of the first spring 4, the first spring 4 pulls the first rotating plate 8 to rotate. The first rotating plate 8 drives the first baffle 7 to slide in the first chute 6, squeezing the liquid storage cavity 201 at the bottom of the funnel 2. The mixed liquid in the liquid storage cavity 201 is squeezed through the nozzle 202 and sprayed into the sampling tube 1 to be mixed with the saliva sample.
[0054] When the first baffle 7 continues to move forward and squeeze the liquid storage cavity 201, due to the elasticity of the side wall, the entire liquid storage cavity 201 will be subjected to a downward squeezing force. This squeezing force acts not only on the mixed liquid but also on the connection between the funnel 2 and the sampling tube 1. Under the continuous action of the squeezing force, the top of the funnel 2 and the sampling tube 1 becomes loose and finally leads to the separation of the funnel 2 and the sampling tube 1. All the first baffles 7 finally form a cover during the movement process, providing a preliminary seal for the sampling tube 1.
[0055] As the total weight of the mixed liquid and the saliva sample increases, the sampling tube 1 continues to move downward. Subsequently, the second wedge 302 is inserted into the second circular hole 104, pushing out the second protrusion 17 in the second circular hole 104. By the same principle, using the restoring force of the second spring 11, the second rotating plate 15 rotates, driving the second baffle 14 to slide in the second chute 13, and finally forming a sealing cover to further enhance the sealing effect of the sampling tube 1.
[0056] After confirming that the sampling tube 1 is completely sealed, the sampling tube 1 is smoothly taken out from the housing 3 of the holding assembly. The sampling tube 1 is sent to the laboratory for further tumor gene detection and analysis.
[0057] Embodiment 2:
[0058] As shown in the attached Figure 6 figure, the difference from Embodiment 1 is that a limiting assembly for preventing the sampling tube 1 from falling is installed at the bottom of the housing 3. The limiting assembly includes a circular ring 303 and sliders. The circular ring 303 is fixedly connected to the inner side wall of the bottom of the housing 3. Special-shaped chutes 304 are provided on both sides of the inner side wall of the housing 3. In this embodiment, the special-shaped chute 304 is a Z-shaped structure. One end of the special-shaped chute 304 penetrates through the circular ring 303. The sliders are slidably engaged with the special-shaped chute 304. The sides of the sliders away from the special-shaped chute 304 are fixedly connected to the outer side walls on both sides of the sampling tube 1. Gripping parts are provided on both sides of the outer side wall of the housing 3, and anti-slip patterns are fixedly connected to the gripping parts.
[0059] The specific implementation process is as follows: When the sampling tube 1 moves downward with the change of weight, the sliders on the sampling tube 1 slide in the special-shaped chute 304, and the circular ring 303 at the bottom prevents the sampling tube 1 from directly falling out of the housing 3. After the internal sealing is completed, the sampling tube 1 is rotated. When the sampling tube 1 is rotated, the sliders will rotate along the curved section (the turning part of the Z-shaped) of the special-shaped chute 304. Due to the design of the special-shaped chute 304, this rotation action will guide the sampling tube 1 to gradually disengage from the housing 3. The patient needs to continuously rotate the sampling tube 1 until the sliders completely slide out of the special-shaped chute 304, at which time the sampling tube 1 can be completely taken out of the housing 3.
[0060] Embodiment 3:
[0061] The difference from Example 2 is that a notch is provided on the side wall of the funnel 2, and a baffle passes through the notch. One end of the baffle located outside the funnel 2 is fixedly connected to a third energy storage member. In this embodiment, the third energy storage member is a third spring (not shown in the figure). One end of the third energy storage member is fixedly connected to the outer wall of the funnel 2, and the baffle is embedded in the top of the liquid storage cavity 201 and is movably fitted.
[0062] The specific implementation process is as follows: Before sampling, the baffle stretches the third spring and then inserts it into the top of the liquid storage cavity 201, and the third spring starts to store energy when stretched. When the sampling tube 1 is moved downward due to the weight of the saliva sample, when the first baffle 7 squeezes the liquid storage cavity 201, the baffle embedded in the top of the liquid storage cavity 201 pops out due to the deformation of the liquid storage cavity 201 under pressure. The reset force of the third spring is used to pull the baffle outside the funnel 2 upward. At the same time, due to the lever structure, the baffle inside the funnel 2 will cover downward, thereby sealing the funnel 2 and preventing the saliva sample from entering the sampling tube 1 again.
[0063] Example 4:
[0064] The difference from Example 3 is that a spiral liquid flow groove is provided on the inner side wall of the sampling tube 1, and the liquid flow groove extends from the bottom of the sampling tube 1 to the top of the sampling tube 1.
[0065] The specific implementation process is as follows: When the saliva sample is collected into the sampling tube 1, the sample will naturally settle at the bottom of the sampling tube 1. Subsequently, the mixed liquid is sprayed into the sampling tube 1 through the nozzle 202. Due to the existence of the spiral groove, the sprayed mixed liquid will form a spiral flow along the groove. This spiral flow not only promotes the full mixing of the mixed liquid and the saliva sample, reduces the situation of uneven mixing, but also effectively reduces the residue of the saliva sample on the inner side wall of the sampling tube 1 through the flushing effect.
[0066] Example 5:
[0067] The difference from Example 4 is that a cover body is adhesively and fixedly connected to the top of the funnel 2, and the cover body is made of a disposable film (not shown in the figure). The disposable film has good sealing performance and easy breakability, which can ensure the cleanliness inside the funnel 2 while being convenient for the patient to break it easily during use.
[0068] The specific implementation process is as follows: When the sampling device is needed to collect a saliva sample, the patient will first notice the cover body on the top of the funnel 2. The patient pinches both sides of the funnel 2 with both hands and exerts force towards the middle. During this process, the cover body made of the disposable film will be squeezed and gradually broken. As the cover body breaks, the patient can spit the saliva sample into the funnel 2 for subsequent sampling operations.
[0069] The design of the disposable film cover prevents contamination of the interior of the funnel 2 by external pollutants before the patient uses it. This ensures the hygiene of the sampling process and the purity of the sample. The patient can easily break the cover simply by pinching both sides of the funnel 2 and applying force, without the need for additional tools or complex operating procedures. This makes the sampling process more convenient and faster. The cost of the disposable film cover is relatively low, which helps to reduce the overall cost of the sampling device and the generation of medical waste. Since the cover material is soft and easy to break, the patient will not feel discomfort or pain in the hand when breaking the cover. This improves the comfort and satisfaction of the patient. Obviously, the above embodiments are only examples given for clear illustration and are not limitations on the implementation manners. For those of ordinary skill in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to enumerate all the implementation manners here. And the obvious changes or modifications derived therefrom are still within the protection scope of the present invention.
Claims
1. A tumor gene detection sampling device, characterized in that: The device comprises a sampling tube (1) and a funnel (2), wherein the sampling tube (1) and the funnel (2) are detachably connected, a gripping component for taking and a releasing component for releasing a mixed liquid are installed between the sampling tube (1) and the funnel (2), a liquid storage cavity (201) is installed on the outer wall of the funnel (2), a liquid outlet is provided at the bottom of the liquid storage cavity (201), and a nozzle (202) is installed at the liquid outlet; The release component comprises a first force storage component, a first installation cavity (101) is provided on the side wall of the sampling tube (1), a plurality of first fixing plates (5) are fixedly connected to the side wall of the installation cavity along the circumference of the sampling tube (1), a first slide groove (6) is provided on the top of each of the first fixing plates (5), each of the first slide grooves (6) is slidably matched with a first baffle plate (7), one end of the first force storage component is fixedly connected to the inner side wall of the installation cavity, the other end of the first force storage component is fixedly connected to a first rotating plate (8), a first notch (9) matching the first slide groove (6) is provided on the first rotating plate (8), the first notch (9) is slidably matched with a side of the first baffle plate (7) away from the first slide groove (6), a first protrusion (10) is provided on the side wall of the first rotating plate (8), a first circular hole (103) matching the first protrusion (10) is provided on the side wall of the installation cavity, and a first wedge block (301) is matched with the first circular hole (103) is provided in the holding component.
2. The tumor gene detection sampling device according to claim 1, characterized in that: A sealing assembly for sealing the sampling tube (1) is installed in the sampling tube (1), the sealing assembly is located below the release assembly, the sealing assembly includes a second force storage member, a second installation cavity (102) is provided on the side wall of the sampling tube (1), a plurality of second fixing plates (12) are fixedly connected to the side wall of the installation cavity along the circumference of the sampling tube (1), a second slide groove (13) is provided on the top of each of the second fixing plates (12), each of the second slide grooves (13) is slidably matched with a second baffle plate (14), one end of the second force storage member is fixedly connected to the inner side wall of the installation cavity, and the second force storage member is fixedly connected to the inner side wall of the installation cavity. The other end of the component is fixedly connected to a second rotating plate (15), and a second notch (16) matching the second slide groove (13) is provided on the second rotating plate (15), and the second notch (16) is slidably matched with the side of the second baffle (14) away from the second slide groove (13), and a second protrusion (17) is provided on the side wall of the second rotating plate (15), and a second circular hole (104) matching the second protrusion (17) is provided on the side wall of the installation cavity, and a second wedge block (302) matching the second circular hole (104) is provided in the gripping assembly.
3. The tumor gene detection sampling device according to claim 1, characterized in that: The cross section of the liquid storage chamber (201) is an inverted trapezoidal structure, the side walls of the liquid storage chamber (201) are made of elastic material, and the nozzles (202) at the bottom of the liquid storage chamber (201) are all facing the side walls of the sampling tube (1).
4. The tumor gene detection sampling device according to claim 2, characterized in that: A guide groove is provided on the outer side wall of the liquid storage cavity (201), and one end of the first baffle (7) away from the first slide groove (6) is slidably engaged with the guide groove.
5. The tumor gene detection sampling device according to claim 2, characterized in that: The holding assembly comprises a shell (3), a first wedge block (301) and a second wedge block (302) are fixedly connected to the inner wall of the shell (3) in sequence from top to bottom, and a limiting assembly for preventing the sampling tube (1) from falling is installed at the bottom of the shell (3).
6. The tumor gene detection sampling device according to claim 5, characterized in that: The limiting assembly comprises a circular ring (303) and a sliding block, wherein the circular ring (303) is fixedly connected to the inner side wall of the bottom of the shell (3), and both sides of the inner side wall of the shell (3) are provided with special-shaped sliding grooves (304), one end of the special-shaped sliding grooves (304) passes through the circular ring (303), and the sliding blocks are slidably matched with the special-shaped sliding grooves (304), and the side of the sliding block away from the special-shaped sliding grooves (304) is respectively fixedly connected to the outer side walls of both sides of the sampling tube (1).
7. The tumor gene detection sampling device according to claim 6, characterized in that: Grip portions are provided on both sides of the outer side wall of the shell (3), and the grip portions are fixedly connected with anti-slip grooves.
8. The tumor gene detection sampling device according to claim 7, characterized in that: A notch is provided on the side wall of the funnel (2), a baffle plate passes through the notch, one end of the baffle plate located outside the funnel (2) is fixedly connected to a third force storage member, one end of the third force storage member is fixedly connected to the outer wall of the funnel (2), and the baffle plate is embedded in the top of the liquid storage cavity (201) and is movably matched.
9. The tumor gene detection sampling device according to claim 1, characterized in that: The inner wall of the sampling tube (1) is provided with a spiral liquid flow groove, and the liquid flow groove extends from the bottom of the sampling tube (1) to the top of the sampling tube (1).
10. The tumor gene detection sampling device according to claim 1, characterized in that: The sampling tube (1) is made of a transparent material, and a scale line is provided on the side wall of the sampling tube (1).