A biomass nanocomposite for relieving rhinitis and a preparation method thereof

Abstract

This invention discloses a biomass nanocomposite for relieving rhinitis and its preparation method, belonging to the field of new materials. It includes a dressing containing a biomass nanomedicine layer. The dressing comprises a fixed adhesive layer and a movable adhesive layer bonded together, with the biomass nanomedicine layer adsorbed on the movable adhesive layer. The fixed adhesive layer includes a flexible substrate, with a base adhesive layer bonded to one side and a top adhesive layer bonded to the other side. The base adhesive layer comprises methyl methacrylate-grafted modified SIS hot-melt pressure-sensitive adhesive, hyaluronic acid silicone gel, and nano-aluminum magnesium silicate. The top adhesive layer comprises benzophenone photoinitiator, acrylic acid-grafted modified SIS hot-melt pressure-sensitive adhesive, nano-titanium dioxide, quaternary ammonium salt-modified chitosan, and N,N'-methylenebisacrylamide. The movable adhesive layer comprises a hydrogel drug carrier, with the biomass nanomedicine layer adsorbed on the hydrogel drug carrier. This invention effectively avoids skin damage caused by repeated pulling of the adhesive layer.

Description

Technical Field

[0001] This invention belongs to the field of new materials and relates to a biomass nanocomposite for relieving rhinitis and its preparation method. Background Technology

[0002] There are many types of nasal dressings that relieve rhinitis by being applied to the nose. The most common type is the nasal patch. The nasal patch consists of a medicated layer and an adhesive layer. The medicated layer contains drugs that can be absorbed through the skin or are volatile and absorbent. They are easy to use and can relieve the discomfort of rhinitis.

[0003] In existing nasal patches, the drug layer and adhesive layer are an integral structure. To ensure a tight fit between the adhesive layer and the skin, the adhesive layer has a high peel strength. When the drug loses its effectiveness, the entire nasal patch needs to be replaced. Frequent replacement of the entire nasal patch within a certain period of time causes the adhesive layer of the nasal patch to repeatedly pull on the skin, resulting in skin damage. This is especially true for volatile drugs with short-lived effects, which require frequent replacement of nasal patches in a short period of time, causing significant damage to the skin. Summary of the Invention

[0004] The purpose of this invention is to provide a biomass nanocomposite for relieving rhinitis and its preparation method, which solves the problem that in existing rhinitis patches, the drug layer and the adhesive layer are an integral structure. When the drug loses its efficacy, the entire rhinitis patch needs to be replaced. Frequent replacement of rhinitis patches in a short period of time causes the adhesive layer of the rhinitis patch to repeatedly pull on the skin, resulting in skin damage.

[0005] The technical solution adopted in this invention is as follows:

[0006] A biomass nanocomposite for relieving rhinitis includes a dressing containing a biomass nanomedicine layer. The dressing includes a fixed adhesive layer and a movable adhesive layer that are bonded together. The biomass nanomedicine layer is adsorbed onto the movable adhesive layer. The fixed adhesive layer includes a flexible substrate. A base adhesive layer is bonded to one side of the flexible substrate, and a top adhesive layer is bonded to the other side of the flexible substrate. The fixed adhesive layer has through-holes that pass through the base adhesive layer, the flexible substrate, and the top adhesive layer, and the through-holes contain the biomass nanomedicine layer.

[0007] The base layer comprises the following components: methyl methacrylate grafted modified SIS hot melt pressure-sensitive adhesive, hyaluronic acid silicone gel, and nano-aluminum magnesium silicate;

[0008] The adhesive layer comprises the following components: benzophenone photoinitiator, acrylic graft-modified SIS hot melt pressure-sensitive adhesive, nano titanium dioxide, quaternary ammonium salt modified chitosan, and N,N'-methylenebisacrylamide.

[0009] The active adhesive layer includes a hydrogel drug carrier, a biomass nano-drug layer is adsorbed on the hydrogel drug carrier, and the hydrogel drug carrier is bonded to the surface adhesive layer of the fixed adhesive layer.

[0010] Among them, the peel strength between the base layer and the substrate it is bonded to is greater than the peel strength between the top layer and the active adhesive layer.

[0011] This invention is based on a biomass nano-drug layer and mainly improves the adhesive layer. By utilizing the different peel strengths between the various adhesive layers, a split-type nasal patch can be obtained. When changing the medication, only the movable adhesive layer needs to be replaced, while the fixed adhesive layer that adheres to the skin remains stationary. This prevents repeated pulling of the skin when frequently changing the medication layer, reducing the risk of skin damage.

[0012] Pressure-sensitive adhesive is a commonly used colloid in dressings such as nose strips. This invention is an improvement on pressure-sensitive adhesive.

[0013] The principle of this invention is as follows: The fixed adhesive layer uses a flexible substrate (non-woven fabric) as the base, and two different adhesive layers are set on its two sides, namely a top adhesive layer and a bottom adhesive layer. The peel strength of the bottom adhesive layer is greater than that of the top adhesive layer. The bottom adhesive layer adheres to the skin, and the top adhesive layer adheres to the movable adhesive layer. The movable adhesive layer is used to support the biomass nano-drug layer. This invention improves the composition of each adhesive layer so that the adhesion strength between the movable adhesive layer and the top adhesive layer is less than the adhesion strength between the bottom adhesive layer and the skin, which is less than the adhesion strength between the top adhesive layer and the bottom adhesive layer. Within this peel strength relationship, when changing the drug layer, the old movable adhesive layer is completely peeled off from the fixed adhesive layer, leaving the fixed adhesive layer on the skin. Then, the new movable adhesive layer containing the new drug layer is adhered to the fixed adhesive layer, thus completing the dressing drug replacement without repeatedly pulling the skin.

[0014] To prevent separation between the topcoat and basecoat layers, this invention employs a photoinitiator, methyl methacrylate-grafted modified SIS hot-melt pressure-sensitive adhesive, and acrylic acid-grafted modified SIS hot-melt pressure-sensitive adhesive. Under light and the action of the photoinitiator, methyl methacrylate and acrylic acid polymerize, strengthening the adhesion between the topcoat and basecoat layers. The flexible substrate has excellent breathability and porosity, allowing the topcoat and basecoat layers to fuse together through the flexible substrate before curing. Under the action of the initiator and crosslinking agent, they undergo a chemical reaction, forming strong chemical bonds that are difficult to separate. The basecoat layer in the above formulation of this invention is also peelable from the skin, making it easy to remove without damaging the skin.

[0015] The hyaluronic acid silicone gel in this invention has the functions of moisturizing and repairing damaged skin, and can relieve the discomfort of the base layer adhering to the skin.

[0016] In this invention, nano-aluminum magnesium silicate swells into a colloid after absorbing water, which can reduce the influence of sweat on the adhesive properties of the base layer.

[0017] In this invention, the base layer needs to be in direct contact with the skin. While ensuring strong peel strength, it is also necessary to reduce the impact of the base layer on the skin. Therefore, this invention incorporates hyaluronic acid silicone gel. In actual use, sweat is easily present on the skin, which reduces the adhesiveness of the base layer. Therefore, this invention incorporates nano-aluminum magnesium silicate into the base layer. In the process of adding nano-aluminum magnesium silicate, the main consideration is to ensure good compatibility and dispersibility between nano-aluminum magnesium silicate and other components of the base layer.

[0018] Furthermore, the amount of benzophenone photoinitiator added to the adhesive layer is 1-3% of the total mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive; the mass ratio of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive to the quaternary ammonium salt-modified chitosan is 6-7:1; the amount of nano-titanium dioxide added is 1.4-1.5% of the mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive; and the amount of N,N'-methylenebisacrylamide added is 0.5-1% of the total mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive.

[0019] Furthermore, the mass ratio of the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive to the hyaluronic acid silicone gel in the base layer is 4:1, and the amount of nano-aluminum magnesium silicate added is 2-3% of the mass of the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive.

[0020] Furthermore, the active adhesive layer also includes a flexible substrate, one side of the hydrogel drug carrier is adhered to one side of the flexible substrate by an adhesive, and the other side of the hydrogel drug carrier is adsorbed with a biomass nano-drug layer.

[0021] The adhesive comprises the following components in parts by weight: carrageenan, carboxymethyl chitosan, ethyl aminosulfonate glue, and glutaraldehyde. The mass ratio of carrageenan, carboxymethyl chitosan, and ethyl aminosulfonate glue is 1:2:0.3, and the amount of glutaraldehyde added is 0.5% of the mass of carboxymethyl chitosan.

[0022] Among them, the peel strength between the hydrogel drug carrier and the flexible substrate is greater than the peel strength between the primer layer and the substrate it is bonded to.

[0023] In this invention, the hydrogel drug carrier is firmly bonded to a flexible substrate via an adhesive, preventing it from easily detaching and ensuring the integrity of the movable adhesive layer. The hydrogel drug carrier in this invention is the hydrogel layer itself, with the drug layer adhering to it. The hydrogel and the adhesive layer are not only bonded together but also easy to peel off, leaving no adhesive residue after peeling. The flexible substrate in this invention is generally non-woven fabric. The adhesive designed in this invention has good compatibility with both the hydrogel and the non-woven fabric, thus acting as a bridge to strengthen the adhesion between them, ensuring that the non-woven fabric and hydrogel do not separate when the movable adhesive layer is removed. The non-woven fabric provides support for the hydrogel layer.

[0024] Furthermore, the biomass nanomedicine layer is composed of biomass carbon nanospheres; the nanopores on the biomass carbon nanospheres adsorb the following substances: menthol, borneol, honeysuckle flower extract, and cocklebur extract.

[0025] Furthermore, the hydrogel drug carrier with the adsorbed biomass nanomedicine layer was prepared by the following method: gelatin was added to water, stirred, and heated until the gelatin dissolved. After cooling and adjusting the pH to 6-7, sodium alginate solution and polyvinyl alcohol solution were added. After stirring for 10 minutes, calcium chloride solution and biomass nanomedicine were added. After reacting for 30-40 minutes, the mixture was solidified to obtain the hydrogel drug carrier, in which the biomass nanomedicine formed a biomass nanomedicine layer on the hydrogel drug carrier. The mass ratio of gelatin, sodium alginate, and polyvinyl alcohol was 2:1:1, and the amount of calcium chloride added was 0.5%-0.6% of the mass of sodium alginate.

[0026] Furthermore, the sodium alginate is a low molecular weight sodium alginate with a molecular weight in the range of 2000-3000.

[0027] Furthermore, the flexible substrate is a nonwoven fabric impregnated with a silane coupling agent.

[0028] The method for preparing a biomass nanocomposite for relieving rhinitis includes the following steps:

[0029] S1. Preparation of the fixing adhesive layer:

[0030] S1.1 Obtaining a flexible substrate: using a nonwoven fabric impregnated with a silane coupling agent as the flexible substrate;

[0031] S1.2 Preparation of the base layer: methyl methacrylate is used to modify the SIS hot melt pressure-sensitive adhesive to obtain methyl methacrylate grafted modified SIS hot melt pressure-sensitive adhesive. Hyaluronic acid silicone gel is added to the methyl methacrylate grafted modified SIS hot melt pressure-sensitive adhesive. After stirring continuously for 1 hour, aluminum magnesium silicate particles are added. After stirring for 30-40 minutes, the base layer is obtained. The base layer is evenly coated on one side of the flexible substrate to obtain the base layer.

[0032] S1.3 Preparation of the topcoat layer: Acrylic acid is used to modify the SIS hot melt pressure-sensitive adhesive to obtain acrylic acid grafted modified SIS hot melt pressure-sensitive adhesive; at 50°C, quaternary ammonium salt modified chitosan solution is added to the acrylic acid grafted modified SIS hot melt pressure-sensitive adhesive, and after stirring and mixing, N,N'-methylenebisacrylamide is added. After stirring and reacting for 1 hour, benzophenone photoinitiator and nano titanium dioxide are added and mixed evenly to obtain the topcoat. The topcoat is evenly coated on the other side of the flexible substrate coated with the base coat in S1.2 to form the topcoat layer. The topcoat layer and the base coat are located on both sides of the flexible substrate, respectively.

[0033] S1.4. Use ultraviolet light to treat the flexible substrate coated with the top adhesive layer and the base adhesive layer. Irradiate with ultraviolet light for 2-3 minutes, and finally cure to form a fixed adhesive layer.

[0034] S2. Preparation of active adhesive layer: Using non-woven fabric impregnated with silane coupling agent as flexible substrate, the hydrogel drug carrier adsorbed with biomass nanomedicine is adhered to one side of the flexible substrate by adhesive to obtain active adhesive layer.

[0035] S3. Preparation of dressing: The hydrogel drug carrier is pressed and bonded to the surface adhesive layer of the fixed adhesive layer. The biomass nano-drug is contained in the through-pores of the fixed adhesive layer. The combination of the movable adhesive layer and the fixed adhesive layer forms the dressing.

[0036] S4. Packaging: After protecting the base layer of the dressing with release paper, the dressing is sealed and packaged to obtain a biomass nanocomposite for relieving rhinitis.

[0037] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0038] 1. The present invention provides a biomass nanocomposite for relieving rhinitis, which utilizes the difference between the adhesive strength between the active adhesive layer and the fixed adhesive layer and the adhesive strength between the fixed adhesive layer and the skin. This allows the active adhesive layer on the surface of the fixed adhesive layer to be replaced only when the medication is frequently changed, without having to replace the entire dressing structure, effectively preventing the skin from being damaged by repeated pulling of the adhesive layer.

[0039] 2. The present invention provides a biomass nanocomposite for relieving rhinitis, with biomass carbon nanospheres as the main structure, which realizes the sustained release of drugs, avoids the rapid deactivation of volatile drugs, and the slower the drug deactivation rate, the longer the service life, and reduces the frequency of drug layer replacement.

[0040] 3. This invention uses a flexible substrate, mainly non-woven fabric, as the supporting structure, combined with a flexible adhesive layer, so that the entire drug layer and adhesive layer complex have good flexibility. Attached Figure Description

[0041] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly described below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort, wherein:

[0042] Figure 1 This is a schematic diagram of the fixed adhesive layer structure of the present invention;

[0043] Figure 2 This is a schematic diagram of the active adhesive layer structure of the present invention;

[0044] The diagram is labeled as follows: 1-fixed adhesive layer, 11-through pore, 2-movable adhesive layer, 21-biomass nanomedicine layer. Detailed Implementation

[0045] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only for explaining the invention and are not intended to limit the invention; that is, the described embodiments are merely some embodiments of the invention, and not all embodiments. The components of the embodiments of the invention described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0046] Therefore, the following detailed description of the embodiments of the invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the invention without inventive effort are within the scope of protection of the invention.

[0047] It should be noted that relational terms such as "first" and "second" are used merely to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0048] The features and performance of the present invention will be further described in detail below with reference to embodiments.

[0049] Example 1

[0050] like Figure 1 , Figure 2 As shown, a preferred embodiment of the present invention provides a biomass nanocomposite for relieving rhinitis, comprising a dressing containing a biomass nanomedicine layer. The dressing includes a fixed adhesive layer 1 and a movable adhesive layer 2 that are bonded together. The movable adhesive layer 2 is adsorbed with a biomass nanomedicine layer 21. The fixed adhesive layer 1 has through holes 11 that pass through a base adhesive layer, a flexible substrate, and a top adhesive layer. When the movable adhesive layer 2 is bonded to the fixed adhesive layer 1, the through holes 11 contain the biomass nanomedicine layer 21. The biomass nanomedicine layer 21 in the through holes 11 can come into contact with the skin when pressed and pasted. After the drug in the biomass nanomedicine layer volatilizes, it is inhaled, which helps to relieve the discomfort of rhinitis.

[0051] The fixing adhesive layer 1 includes a flexible substrate, which is a non-woven fabric impregnated with a silane coupling agent. A base adhesive layer is bonded to one side of the flexible substrate, and a top adhesive layer is bonded to the other side of the flexible substrate. The base adhesive layer of the fixing adhesive layer 1 is bonded to the skin, and the top adhesive layer of the fixing adhesive layer 1 is bonded to the movable adhesive layer 2 and the top adhesive layer of the fixing adhesive layer 1 and the movable adhesive layer 2 can be peeled off.

[0052] The base layer of the fixed adhesive layer 1 includes the following components: methyl methacrylate grafted modified SIS hot melt pressure sensitive adhesive, hyaluronic acid silicone gel, and nano-aluminum magnesium silicate particles, wherein the mass ratio of methyl methacrylate grafted modified SIS hot melt pressure sensitive adhesive to hyaluronic acid silicone gel is 4:1, and the amount of nano-aluminum magnesium silicate particles added is 2-3% of the mass of methyl methacrylate grafted modified SIS hot melt pressure sensitive adhesive;

[0053] The topcoat layer of the fixed adhesive layer 1 comprises the following components: benzophenone photoinitiator, acrylic-grafted modified SIS hot melt pressure-sensitive adhesive, nano-titanium dioxide, quaternary ammonium salt modified chitosan, and N,N'-methylenebisacrylamide. The amount of benzophenone photoinitiator added is 1% of the total mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive. The mass ratio of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive to the quaternary ammonium salt modified chitosan is 6-7:1. The amount of nano-titanium dioxide added is 1.4-1.5% of the mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive. The amount of N,N'-methylenebisacrylamide added is 0.5% of the total mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive.

[0054] The active adhesive layer 2 includes a flexible substrate and a hydrogel drug carrier. The flexible substrate is a non-woven fabric impregnated with a silane coupling agent. One side of the hydrogel drug carrier is adhered to the other side of the flexible substrate by an adhesive. A biomass nano-drug layer 21 is adsorbed on the other side of the hydrogel drug carrier. The biomass nano-drug layer 21 is composed of biomass carbon nanospheres. The nanopores on the biomass carbon nanospheres adsorb the following substances: menthol, borneol, honeysuckle flower extract, and cocklebur extract.

[0055] The adhesive between the hydrogel drug carrier and the nonwoven fabric comprises the following components in parts by weight: carrageenan, carboxymethyl chitosan, ethyl aminosulfonate glue, and glutaraldehyde. The mass ratio of carrageenan, carboxymethyl chitosan, and ethyl aminosulfonate glue is 1:2:0.3, and the amount of glutaraldehyde added is 0.5% of the mass of carboxymethyl chitosan. The adhesive is prepared by the following method: carrageenan glue solution and ethyl aminosulfonate glue solution are uniformly mixed, then carboxymethyl chitosan solution is added, stirred evenly, heated to 50°C, glutaraldehyde is added, stirred evenly, reacted for 1.5 hours, and cooled to room temperature to obtain the adhesive.

[0056] The hydrogel drug carrier with the adsorbed biomass nano-drug layer was prepared by the following method: gelatin was added to water at 60°C and stirred until dissolved. The solution was then cooled to 40°C to obtain a gelatin solution. After adjusting the pH to 6-7, sodium alginate solution and polyvinyl alcohol solution were added. After stirring for 10 minutes, calcium chloride solution and biomass nano-drug were added. The reaction was carried out for 30-40 minutes to obtain a hydrogel. After solidification, the hydrogel drug carrier with the adsorbed biomass nano-drug layer was obtained. The mass ratio of gelatin, sodium alginate, and polyvinyl alcohol was 2:1:1, and the amount of calcium chloride added was 0.5%-0.6% of the mass of sodium alginate. The sodium alginate was a low molecular weight sodium alginate with a molecular weight in the range of 2000-3000.

[0057] The method for preparing a biomass nanocomposite for relieving rhinitis includes the following steps:

[0058] S1. Preparation of the fixing adhesive layer:

[0059] S1.1 Obtaining a flexible substrate: using a nonwoven fabric impregnated with a silane coupling agent as the flexible substrate;

[0060] S1.2 Preparation of the base layer: While stirring, a mixed solution of methyl methacrylate and BPO initiator is added dropwise to the molten SIS hot melt pressure-sensitive adhesive. The mass ratio of methyl methacrylate to BPO initiator in the mixed solution is 15:1. The amount of methyl methacrylate added is 7-8% of the mass of the SIS hot melt pressure-sensitive adhesive. After reacting at 80°C for 3 hours, BPO initiator is added. At this time, the amount of BPO initiator added is half of the amount added in the first BPO initiator. After stirring evenly, the reaction continues for 1 hour. Then, the temperature is lowered to 50°C, and terpene resin is added. After stirring evenly, methyl methacrylate grafted modified SIS hot melt pressure-sensitive adhesive is obtained. Hyaluronic acid silicone gel is added to the methyl methacrylate grafted modified SIS hot melt pressure-sensitive adhesive. After stirring continuously for 1 hour, the temperature is lowered to 40°C, and nano-aluminum magnesium silicate particles are added. After stirring for 30-40 minutes, the base layer is obtained. The base layer is evenly coated on one side of the flexible substrate to obtain the base layer.

[0061] S1.3 Preparation of the surface adhesive layer: While stirring, a mixed solution of acrylic acid and BPO initiator is added dropwise to the molten SIS hot melt pressure-sensitive adhesive. The mass ratio of acrylic acid to BPO initiator in the mixed solution is 25:1, and the amount of acrylic acid added is 5% of the mass of the SIS hot melt pressure-sensitive adhesive. After reacting at 70°C for 3.5 hours, BPO initiator is added. At this time, the amount of BPO initiator added is half of the amount added in the first step. After stirring evenly, the reaction continues for 1 hour. Then, the temperature is lowered to 50°C, and terpene resin is added and stirred evenly. Acrylic graft modified SIS hot melt pressure-sensitive adhesive was then obtained; subsequently, at 50°C, quaternary ammonium salt modified chitosan solution was added to the acrylic graft modified SIS hot melt pressure-sensitive adhesive, and after stirring and mixing for 20 minutes, N,N'-methylenebisacrylamide was added. After continuing to react for 1 hour under stirring, benzophenone photoinitiator and nano titanium dioxide were added and mixed evenly to obtain the topcoat. The topcoat was evenly coated on the other side of the flexible substrate coated with the base coat in S1.2 to form the topcoat layer. The topcoat layer and the base coat layer were located on both sides of the flexible substrate, respectively.

[0062] S1.4. Use ultraviolet light to treat the flexible substrate coated with the top adhesive layer and the base adhesive layer. Irradiate with ultraviolet light for 2-3 minutes, and finally cure to form a fixed adhesive layer.

[0063] S2. Preparation of active adhesive layer: Using non-woven fabric impregnated with silane coupling agent as flexible substrate, the hydrogel drug carrier adsorbed with biomass nanomedicine is adhered to one side of the flexible substrate by adhesive to obtain active adhesive layer.

[0064] S3. Preparation of dressing: The hydrogel drug carrier is pressed and bonded to the surface adhesive layer of the fixed adhesive layer. The biomass nano-drug is contained in the through-pores of the fixed adhesive layer. The combination of the movable adhesive layer and the fixed adhesive layer forms the dressing.

[0065] S4. Packaging: After protecting the base layer of the dressing with release paper, the dressing is sealed and packaged to obtain a biomass nanocomposite for relieving rhinitis.

[0066] Example 2

[0067] This embodiment differs from Embodiment 1 in that the amount of benzophenone photoinitiator added to the adhesive layer is 2% of the total mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive.

[0068] Example 3

[0069] This embodiment differs from Embodiment 1 in that the amount of benzophenone photoinitiator added to the adhesive layer is 3% of the total mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive.

[0070] Example 4

[0071] This embodiment differs from Example 2 in that the amount of N,N'-methylenebisacrylamide added is 0.8% of the total mass of the acrylic acid-grafted modified SIS hot-melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot-melt pressure-sensitive adhesive. The efficacy of the biomass nanomedicine layer of this invention can last for more than 12 hours.

[0072] Example 5

[0073] This embodiment differs from Embodiment 2 in that the amount of N,N'-methylenebisacrylamide added is 1% of the total mass of the acrylic acid-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive.

[0074] Comparative Example 1

[0075] This comparative example differs from Example 2 in that the mass ratio of acrylic grafted modified SIS hot melt pressure-sensitive adhesive to quaternary ammonium salt modified chitosan in the adhesive layer of this comparative example is 5:1.

[0076] Comparative Example 2

[0077] This comparative example differs from Example 4 in that the mass ratio of acrylic-grafted modified SIS hot melt pressure-sensitive adhesive to quaternary ammonium salt modified chitosan in the adhesive layer of this comparative example is 8:1.

[0078] Comparative Example 3

[0079] This comparative example differs from Example 4 in that: the hot melt pressure-sensitive adhesive in the top layer of this comparative example is an ungrafted SIS hot melt pressure-sensitive adhesive; the hot melt pressure-sensitive adhesive in the base layer is also an ungrafted SIS hot melt pressure-sensitive adhesive; the top layer does not contain benzophenone photoinitiator; and ultraviolet light is not used to phototreat the flexible substrate coated with the top and base layers.

[0080] Comparative Example 4

[0081] This comparative example differs from Example 4 in that: the adhesive layer in this comparative example does not contain benzophenone photoinitiator; and ultraviolet light is not used to phototreat the flexible substrate coated with the adhesive layer and the base layer.

[0082] Comparative Example 5

[0083] This comparative example differs from Example 4 in that it does not contain a top adhesive layer or an intermediate flexible substrate; the movable adhesive layer is directly bonded to the surface of the base adhesive layer. The peel strength between the movable adhesive layer and the base adhesive layer is much greater than the peel strength between the movable adhesive layer and the top adhesive layer. Since the movable adhesive layer is directly bonded to the base adhesive layer, the dressing change speed is slow, and there will be residual adhesive from the movable adhesive layer on the base adhesive layer.

[0084] Comparative Example 6

[0085] This comparative example differs from Example 4 in that it does not contain a base adhesive layer or an intermediate flexible substrate; the movable adhesive layer is directly bonded to the surface of the top adhesive layer. The peel strength between the movable adhesive layer and the top adhesive layer is essentially the same as the peel strength of the top adhesive layer on the skin. Compared to the base adhesive layer, the top adhesive layer has weaker adhesion, making it easier to peel off during the removal of the movable adhesive layer. In this invention, the adhesive strength of the base adhesive layer is greater than that of the top adhesive layer.

[0086] Comparative Example 7

[0087] This comparative example differs from Example 4 in that the base coat layer of this comparative example does not contain nano-sized magnesium aluminum silicate particles.

[0088] Experimental Example 1

[0089] The 180-degree peel strength Q1 between the active adhesive layer and the top adhesive layer, the 180-degree peel strength Q2 between the top adhesive layer and the base adhesive layer, and the peel strength Q3 of the base adhesive layer in Examples 1-5 and Comparative Examples 1-4 were tested; the test results are shown in Table 1.

[0090] The existing interlayer 180-degree peel strength testing methods are adopted for the 180-degree peel strength testing methods between the active adhesive layer and the top adhesive layer, and between the top adhesive layer and the base adhesive layer.

[0091] The peel strength Q3 of the base adhesive layer was tested according to the peel strength test method in the pharmaceutical industry standard YY / T 0148-2006 "General Requirements for Medical Adhesive Tape": the force required to peel the adhesive layer from the steel plate was measured (the force angle was 180 degrees and the peeling speed was 270 mm / min to 330 mm / min).

[0092] Table 1 Peel strength of each adhesive layer

[0093] Peel strength Q1 Peel strength Q2 Peel strength Q3 Example 1 1.2-1.3 N / cm 6.2-6.3 N / cm 3.2-3.4 N / cm Example 2 1.4-1.5 N / cm 6.4-6.5 N / cm 3.5-3.6 N / cm Example 3 1.0-1.1 N / cm 6.0-6.1 N / cm 3.2-3.4 N / cm Example 4 1.4-1.5 N / cm 6.6-6.7 N / cm 3.6-3.7 N / cm Example 5 1.4-1.6 N / cm 6.8-6.9 N / cm 3.9-4.0 N / cm Comparative Example 1 3.2-3.3 N / cm 7.3-7.4 N / cm 3.6-3.7 N / cm Comparative Example 2 0.5-0.7 N / cm 4.8-5.1 N / cm 3.6-3.7 N / cm Comparative Example 3 1.2-1.3 N / cm 1.2-1.3 N / cm 1.8-2.0 N / cm Comparative Example 4 1.2-1.3 N / cm 2.42.5 / cm 2.5-2.8 N / cm

[0094] In Examples 1-5, after the active adhesive layer separates from the top adhesive layer, there is no residual active adhesive on the top adhesive layer, resulting in a fast peeling speed. Without external force, the active adhesive layer will not easily detach from the top adhesive layer. In this invention, when peeling off the active adhesive layer, the top adhesive layer and the base adhesive layer will not separate, nor will the base adhesive layer detach from the adhesive substrate. In this invention, within this peel strength range, the base adhesive layer possesses both a certain degree of adhesiveness and is easy to peel off, leaving no residue after peeling, and causing negligible harm to the skin.

[0095] In Comparative Example 1, when the proportion of quaternary ammonium salt modified chitosan in the top adhesive layer increases relative to that of acrylic acid grafted modified SIS hot melt pressure-sensitive adhesive, the peel strength between the active adhesive layer and the top adhesive layer increases significantly, and the adhesion between the two is enhanced, which slows down the speed of peeling the active adhesive layer off the top adhesive layer, thus affecting the dressing change efficiency. In addition, after the active adhesive layer and the top adhesive layer separate in Comparative Example 1, there is residual adhesive of the active adhesive layer on the top adhesive layer.

[0096] In Comparative Example 2, when the proportion of quaternary ammonium salt modified chitosan in the top adhesive layer is reduced compared to that of acrylic acid grafted modified SIS hot melt pressure-sensitive adhesive, the adhesion between the active adhesive layer and the top adhesive layer is insufficient, and the active adhesive layer is prone to falling off.

[0097] In Comparative Example 3, during the process of peeling off the active adhesive layer, separation occurred between the surface adhesive layer and the flexible substrate.

[0098] Experimental Example 2

[0099] The peel strength of the base adhesive layer in Examples 1-5 and Comparative Example 7 on a stainless steel plate containing sweat was tested.

[0100] The testing method was as follows: the base adhesive layer was pressed and adhered to a stainless steel plate on which a sweat sample was dripped. The peel strength of the base adhesive layer was measured using a peel tester and recorded as Q4. The use of a peel tester to measure the peel strength of the base adhesive layer is existing technology. The test results are shown in Table 2.

[0101] Table 2 Peel strength of the base adhesive layer

[0102] Example 1 Example 2 Example 3 Example 4 Example 5 Comparative Example 7 Peel strength Q4 3.0-3.1 N / cm 3.3-3.4 N / cm 3.1-3.2 N / cm 3.5-3.6 N / cm 3.7-3.8 N / cm <1N / cm

[0103] In this invention, magnesium aluminum silicate reduces the degree of decrease in adhesiveness after the base layer is soaked in sweat, while the base layer still maintains high adhesiveness and will not detach from the skin in any localized areas. Example 4 of this invention represents the optimal solution.

[0104] The above description is merely a preferred embodiment of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, and improvements made by those skilled in the art within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A biomass nanocomposite for relieving rhinitis, comprising a dressing containing a biomass nanomedicine layer, characterized in that: The dressing includes a fixed adhesive layer (1) and a movable adhesive layer (2) that are bonded together. A biomass nano-drug layer (21) is adsorbed on the movable adhesive layer (2). The fixed adhesive layer (1) includes a flexible substrate. A base adhesive layer is bonded to one side of the flexible substrate, and a top adhesive layer is bonded to the other side of the flexible substrate. A through hole (11) is formed in the fixed adhesive layer (1) that passes through the base adhesive layer, the flexible substrate and the top adhesive layer. The through hole (11) contains the biomass nano-drug layer (21). The base layer comprises the following components: methyl methacrylate grafted modified SIS hot melt pressure-sensitive adhesive, hyaluronic acid silicone gel, and nano-aluminum magnesium silicate; The adhesive layer comprises the following components: benzophenone photoinitiator, acrylic-grafted modified SIS hot melt pressure-sensitive adhesive, nano titanium dioxide, quaternary ammonium salt modified chitosan, and N,N'-methylenebisacrylamide; wherein the mass ratio of acrylic-grafted modified SIS hot melt pressure-sensitive adhesive to quaternary ammonium salt modified chitosan is 6-7:

1. The active adhesive layer (2) includes a hydrogel drug carrier, a biomass nano-drug layer (21) adsorbed on the hydrogel drug carrier, and the hydrogel drug carrier is bonded to the surface adhesive layer of the fixed adhesive layer (1). Among them, the adhesive strength between the active adhesive layer and the top adhesive layer is less than the adhesive strength between the base adhesive layer and the skin, which is less than the adhesive strength between the top adhesive layer and the base adhesive layer.

2. The biomass nanocomposite for relieving rhinitis according to claim 1, characterized in that: The amount of benzophenone photoinitiator added to the adhesive layer is 1-3% of the total mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive; the amount of nano titanium dioxide added is 1.4-1.5% of the mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive; and the amount of N,N'-methylenebisacrylamide added is 0.5-1% of the total mass of the acrylic-grafted modified SIS hot melt pressure-sensitive adhesive and the methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive.

3. The biomass nanocomposite for relieving rhinitis according to claim 2, characterized in that: The mass ratio of methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive to hyaluronic acid silicone gel in the base layer is 4:1, and the amount of nano-aluminum magnesium silicate added is 2-3% of the mass of methyl methacrylate-grafted modified SIS hot melt pressure-sensitive adhesive.

4. The biomass nanocomposite for relieving rhinitis according to claim 1, characterized in that: The active adhesive layer (2) also includes a flexible substrate. One side of the hydrogel drug carrier is adhered to one side of the flexible substrate by an adhesive, and the other side of the hydrogel drug carrier is adsorbed with a biomass nano-drug layer (21). The adhesive comprises the following components in parts by weight: carrageenan, carboxymethyl chitosan, ethyl aminosulfonate gum, and glutaraldehyde, wherein the mass ratio of carrageenan, carboxymethyl chitosan, and ethyl aminosulfonate gum is 1:2:0.3, and the amount of glutaraldehyde added is 0.5% of the mass of carboxymethyl chitosan. Among them, the peel strength between the hydrogel drug carrier and the flexible substrate is greater than the peel strength between the primer layer and the substrate it is bonded to.

5. A biomass nanocomposite for relieving rhinitis according to claim 1, characterized in that: The biomass nanomedicine layer (21) is composed of biomass carbon nanospheres; the following substances are adsorbed in the nanopores on the biomass carbon nanospheres: menthol, borneol, honeysuckle flower extract, and cocklebur extract.

6. A biomass nanocomposite for relieving rhinitis according to claim 4, characterized in that: The hydrogel drug carrier with the adsorbed biomass nano-drug layer (21) was prepared by the following method: gelatin was added to water, stirred and heated until the gelatin dissolved, then cooled and the pH was adjusted to 6-7. Sodium alginate solution and polyvinyl alcohol solution were added, and stirring was continued for 10 minutes. Then calcium chloride solution and biomass nano-drug were added. After reacting for 30-40 minutes, the mixture was solidified to obtain the hydrogel drug carrier. The biomass nano-drug formed a biomass nano-drug layer (21) on the hydrogel drug carrier. The mass ratio of gelatin, sodium alginate and polyvinyl alcohol was 2:1:1, and the amount of calcium chloride added was 0.5%-0.6% of the mass of sodium alginate.

7. A biomass nanocomposite for relieving rhinitis according to claim 6, characterized in that: The sodium alginate is a low molecular weight sodium alginate with a molecular weight in the range of 2000-3000.

8. A biomass nanocomposite for relieving rhinitis according to claim 1 or 4, characterized in that: The flexible substrate is a nonwoven fabric impregnated with a silane coupling agent.

9. A method for preparing a biomass nanocomposite for relieving rhinitis according to any one of claims 1-7, characterized in that: Includes the following steps: S1. Preparation of the fixing adhesive layer: S1.1 Obtaining a flexible substrate: using a nonwoven fabric impregnated with a silane coupling agent as the flexible substrate; S1.2 Preparation of the base layer: methyl methacrylate is used to modify the SIS hot melt pressure-sensitive adhesive to obtain methyl methacrylate grafted modified SIS hot melt pressure-sensitive adhesive. Hyaluronic acid silicone gel is added to the methyl methacrylate grafted modified SIS hot melt pressure-sensitive adhesive. After stirring continuously for 1 hour, aluminum magnesium silicate particles are added. After stirring for 30-40 minutes, the base layer is obtained. The base layer is evenly coated on one side of the flexible substrate to obtain the base layer. S1.3 Preparation of the topcoat layer: Acrylic acid is used to modify the SIS hot melt pressure-sensitive adhesive to obtain acrylic acid grafted modified SIS hot melt pressure-sensitive adhesive; at 50°C, quaternary ammonium salt modified chitosan solution is added to the acrylic acid grafted modified SIS hot melt pressure-sensitive adhesive, and after stirring and mixing, N,N'-methylenebisacrylamide is added. After stirring and reacting for 1 hour, benzophenone photoinitiator and nano titanium dioxide are added and mixed evenly to obtain the topcoat. The topcoat is evenly coated on the other side of the flexible substrate coated with the base coat in S1.2 to form the topcoat layer. The topcoat layer and the base coat are located on both sides of the flexible substrate, respectively. S1.

4. Use ultraviolet light to treat the flexible substrate coated with the top adhesive layer and the base adhesive layer. Irradiate with ultraviolet light for 2-3 minutes, and finally cure to form a fixed adhesive layer. S2. Preparation of active adhesive layer: Using non-woven fabric impregnated with silane coupling agent as flexible substrate, the hydrogel drug carrier adsorbed with biomass nanomedicine is adhered to one side of the flexible substrate by adhesive to obtain active adhesive layer. S3. Preparation of dressing: The hydrogel drug carrier is pressed and bonded to the surface adhesive layer of the fixed adhesive layer. The biomass nano-drug is contained in the through-pores of the fixed adhesive layer. The combination of the movable adhesive layer and the fixed adhesive layer forms the dressing. S4. Packaging: After protecting the base layer of the dressing with release paper, the dressing is sealed and packaged to obtain a biomass nanocomposite for relieving rhinitis.

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