Composite hyaluronic acid wound dressing and preparation method thereof

Abstract

The invention discloses a composite hyaluronic acid wound dressing and a preparation method thereof, and relates to the technical field of medicines.The composite hyaluronic acid wound dressing is composed of a non-woven fabric, a hyaluronic acid dressing body and a packaging bag, the hyaluronic acid dressing body is prepared from hyaluronic acid, glycerin, collagen, plant extract, chitosan, alginate and purified water, and the packaging bag is prepared from the non-woven fabric, the hyaluronic acid dressing body and the packaging bag. The ointment has the beneficial effects that by adding the spina gleditsiae extract, the sarcandra glabra extract and the ajuga taiwanensis extract, the ointment can be used for promoting swelling subsiding and pus expelling of wounds, removing blood stasis and treating wound ulceration under the conditions of ulceration, stasis accumulation and pus generation of the wounds of patients, so that wound recovery of the patients is helped; by adding the aloe extract, the lavender extract, the mint extract and the folium artemisiae argyi extract, scars after wound healing can be prevented and treated through the aloe extract, the itching feeling during wound healing can be relieved through the mint extract during wound healing, and the pain feeling of the wound part can be relieved through the folium artemisiae argyi extract.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and specifically relates to a composite hyaluronic acid wound dressing and a preparation method thereof. Background Art

[0002] The repair of human skin injuries is a complex physiological process. The healing speed of wounds and the formation and hyperplasia of scars after healing have always been problems that trouble people. For this reason, people have been striving to seek ideal dressings, including good biocompatibility, controlling and absorbing wound exudate, preventing bacteria from invading and inhibiting the growth and reproduction of bacteria, protecting new tissues, accelerating wound healing, preventing and reducing scars, hemostasis and analgesia, and good mechanical properties.

[0003] Hyaluronic acid, also known as glucuronic acid, is a high-molecular-weight acidic mucopolysaccharide composed of repeating disaccharide units of N-acetylglucosamine and D-glucuronic acid, and is widely present in the extracellular matrix of connective tissue cells of animals and humans. Hyaluronic acid has a wide range of physical and chemical properties and rich biological functions, and is particularly suitable for the repair, protection and care of the skin. Hyaluronic acid is widely used in the field of skin products (topical drugs, medical devices, cosmetics), but mostly only hyaluronic acid with a certain molecular weight range is used, which only has some properties of hyaluronic acid and cannot exert its full efficacy. Moreover, the performance and efficacy of products with the same name will vary significantly between different enterprises or even different batches of the same enterprise.

[0004] Currently, the main functions of existing dressing products are to promote wound healing, prevent wound infection and provide a good wound healing environment. However, if patients do not receive timely anti-inflammatory and bactericidal treatment when they have wounds or do not protect the wounds properly after treatment, it will lead to situations such as ulceration, congestion and suppuration at the wound site. Existing dressings often cannot effectively restore the wounds in the above situations, and the wounds will cause itching during the recovery process, which will cause serious discomfort to the patients, and existing dressings also cannot relieve the itching of the patients' wound healing. For this reason, we have proposed a composite hyaluronic acid wound dressing. Summary of the Invention

[0005] In view of the deficiencies of the prior art, the present invention provides a composite hyaluronic acid wound dressing and a preparation method thereof, which solve the problems raised in the above background art.

[0006] To achieve the above objectives, the present invention is realized through the following technical solutions: A composite hyaluronic acid wound dressing comprises three parts: a non-woven fabric, a hyaluronic acid dressing and a packaging bag. The hyaluronic acid dressing includes: hyaluronic acid, glycerol, collagen, plant extract, chitosan, alginate and purified water;

[0007] The plant extracts include: Gleditsia sinensis extract, Sarcandra glabra extract, Ajuga nipponensis extract, Aloe vera extract, Lavandula angustifolia extract, Mentha haplocalyx extract, Artemisia argyi extract, and Carthamus tinctorius extract;

[0008] The dressing is evenly soaked with glycerol, collagen, plant extracts, chitosan, alginate, and purified water in hyaluronic acid and non-woven fabric, and the hyaluronic acid is evenly spread and closely attached to one side of the non-woven fabric.

[0009] Preferably, the content of the plant extracts is as follows:

[0010]

[0011] Preferably, the content of the hyaluronic acid dressing is as follows:

[0012]

[0013]

[0014] The balance is purified water.

[0015] Preferably, the non-woven fabric is made of degradable medical fibers.

[0016] Preferably, the packaging bag is a medical aluminum foil bag.

[0017] Preferably, the shape of the hyaluronic acid dressing is a mask-like material in the shape of a strip, square, rectangle, circle, and ellipse.

[0018] Preferably, the size of the hyaluronic acid dressing is as follows: the strip dressing is 5 - 10 cm * 20 - 50 cm, the square dressing is 10 cm - 25 cm, the rectangular dressing is 5 - 20 cm * 20 - 40 cm, the circular dressing is Φ10 - 50 cm, and the elliptical dressing has a major axis of 10 - 40 cm and a minor axis of 8 - 30 cm.

[0019] Preferably, the mass of the non-woven fabric per square meter is not less than 30 g / m2.

[0020] A preparation method of a composite hyaluronic acid wound dressing includes the following steps:

[0021] S1: Composite hyaluronic acid of different shapes on one side of the non-woven fabric;

[0022] S2: Subsequently, load non-woven fabrics of various different specifications and the composite hyaluronic acid into a packaging bag adapted thereto;

[0023] S3: Subsequently, stir glycerol, collagen, various plant extracts, chitosan, alginate, and purified water until evenly mixed;

[0024] S4: Subsequently, after being evenly mixed, it is automatically filled and divided into packaging bags according to different specifications and required capacities, so that it infiltrates into the non-woven fabric and hyaluronic acid.

[0025] S5: Finally, inspection is carried out, and after passing the inspection, it can become a finished product.

[0026] The present invention provides a composite hyaluronic acid wound dressing and its preparation method, which has the following beneficial effects:

[0027] For the composite hyaluronic acid wound dressing and its preparation method, by adding extracts of Gleditsia sinensis, Sarcandra glabra, and Saururus chinensis, it can promote wound detumescence and pus drainage, remove stasis, and treat wound ulceration in the case of wound festering, stasis, and suppuration, thereby helping the patient's wound to recover. By adding extracts of Aloe vera, Lavandula angustifolia, Mentha haplocalyx, and Artemisia argyi, the extract of Aloe vera can prevent scarring after wound healing, the extract of Mentha haplocalyx can relieve the itching sensation during wound healing, the extract of Artemisia argyi can relieve the pain at the wound site, and the extract of Lavandula angustifolia can not only promote wound healing but also provide the fragrance of lavender to cover the odor of festering and suppurating wounds. Specific Embodiments

[0028] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments.

[0029] Embodiment 1

[0030] The present invention provides a technical solution: a composite hyaluronic acid wound dressing, which consists of three parts: a non-woven fabric, a hyaluronic acid dressing, and a packaging bag. The hyaluronic acid dressing includes: hyaluronic acid, glycerol, collagen, plant extracts, chitosan, alginate, and purified water.

[0031] The non-woven fabric is made of degradable medical fibers, the packaging bag is a medical aluminum foil bag, and the mass of the non-woven fabric per square meter is not less than 30 g / m2.

[0032] The shape of the hyaluronic acid dressing is a mask-like material in the shape of a strip, square, rectangle, circle, and ellipse;

[0033] The size of the hyaluronic acid dressing is: the strip-shaped dressing is 5 - 10 cm * 20 - 50 cm, the square dressing is 10 cm - 25 cm, the rectangular dressing is 5 - 20 cm * 20 - 40 cm, the circular dressing is Φ10 - 50 cm, and the elliptical dressing has a major axis of 10 - 40 cm and a minor axis of 8 - 30 cm.

[0034] The plant extract includes: Gleditsia sinensis extract, Sarcandra glabra extract, Ajuga nipponensis extract, Aloe vera extract, Lavandula angustifolia extract, Mentha haplocalyx extract, Artemisia argyi extract, and Carthamus tinctorius extract;

[0035] The dressing is uniformly soaked with glycerin, collagen, plant extract, chitosan, alginate, and purified water in hyaluronic acid and non-woven fabric, and the hyaluronic acid is evenly spread and closely attached to one side of the non-woven fabric.

[0036] Example 2

[0037] The content of the components of the hyaluronic acid dressing is as follows:

[0038]

[0039] The balance is purified water.

[0040] Example 3

[0041] The content of the components of the hyaluronic acid dressing is as follows:

[0042]

[0043] The balance is purified water.

[0044] Example 4

[0045] The content of the components of the hyaluronic acid dressing is as follows:

[0046]

[0047] The balance is purified water.

[0048] Example 5

[0049] The content of the components of the hyaluronic acid dressing is as follows:

[0050]

[0051] The balance is purified water.

[0052] Example 6

[0053] The content of the components of the plant extract is as follows:

[0054]

[0055] Example 7

[0056] The content of the components of the plant extract is as follows:

[0057]

[0058]

[0059] Example VIII

[0060] The content of the plant extract composition is as follows:

[0061]

[0062] Example IX

[0063] The content of the plant extract composition is as follows:

[0064]

[0065] Example X

[0066] The content of the plant extract composition is as follows:

[0067]

[0068] A preparation method of a composite hyaluronic acid wound dressing includes the following steps:

[0069] S1: Composite hyaluronic acid of different shapes on one side of the non-woven fabric;

[0070] S2: Then put non-woven fabrics of various different specifications and the composite hyaluronic acid into a packaging bag adapted thereto;

[0071] S3: Then stir glycerol, collagen, various plant extracts, chitosan, alginate and purified water until evenly mixed;

[0072] S4: Then automatically fill and divide the evenly mixed product into packaging bags according to different specifications and required capacities so that it infiltrates into the non-woven fabric and hyaluronic acid;

[0073] S5: Finally, conduct inspections, and the finished product can be obtained after passing the inspections.

[0074] As described above, it is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution of the present invention and its inventive concept, makes equivalent substitutions or changes, and all should be covered within the protection scope of the present invention.

Claims

1. A composite hyaluronic acid wound dressing, comprising a non-woven fabric, a hyaluronic acid dressing and a packaging bag, characterized in that: The hyaluronic acid dressing comprises: hyaluronic acid, glycerol, collagen, plant extract, chitosan, alginate and purified water; The plant extracts include: Gleditsia sinensis extract, Rhizoma Cibotii extract, Herba Lycopodii extract, Aloe vera extract, Lavender extract, Peppermint extract, Artemisia argyi extract and Safflower extract; The dressing glycerol, collagen, plant extract, chitosan, alginate and purified water are evenly soaked in hyaluronic acid and non-woven fabric, and the hyaluronic acid is evenly spread and closely attached to one side of the non-woven fabric.

2. A composite hyaluronic acid wound dressing according to claim 1, characterized in that: The content of the plant extract composition is:

3. A composite hyaluronic acid wound dressing according to claim 1, characterized in that: The content of the hyaluronic acid dressing composition is: The remainder was purified water.

4. The composite hyaluronic acid wound dressing according to claim 1, characterized in that: The non-woven fabric is made of degradable medical fibers.

5. The composite hyaluronic acid wound dressing according to claim 1, characterized in that: The packaging bag is a medical aluminum foil bag.

6. The composite hyaluronic acid wound dressing according to claim 1, characterized in that: The hyaluronic acid dressing is in the shape of a long strip, square, rectangle, circle or oval mask-like material.

7. The composite hyaluronic acid wound dressing according to claim 1, characterized in that: The sizes of the hyaluronic acid dressings are: 5-10cm*20-50cm for long strip dressings, 10cm-25cm for square dressings, 5-20cm*20-40cm for rectangular dressings, Φ10-50cm for round dressings, and 10-40cm for the long axis and 8-30cm for the short axis of elliptical dressings.

8. The composite hyaluronic acid wound dressing according to claim 1, characterized in that: The mass of the nonwoven fabric per square meter is not less than 30g / m2.

9. A method for preparing a composite hyaluronic acid wound dressing, characterized in that: The following steps are involved: S1: Compounding hyaluronic acid of different shapes on one side of non-woven fabric; S2: Then, the non-woven fabrics of various specifications and the composited hyaluronic acid are put into suitable packaging bags; S3: Then, glycerol, collagen, various plant extracts, chitosan, alginate and purified water are stirred until they are well mixed; S4: After the mixture is evenly mixed, it is automatically filled into packaging bags according to different specifications and required volumes so that the mixture is soaked into the non-woven fabric and hyaluronic acid; S5: Finally, the product is inspected and becomes finished product after passing the inspection.

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