Solid-phase microextraction film fixing device for liquid sample volumes with multiple specifications

Abstract

The invention discloses a solid-phase micro-extraction film fixing device for liquid sample volumes of multiple specifications. The device comprises a base; the lifting platform is movably arranged on the base; the power mechanism drives the lifting platform to do lifting motion relative to the base; the clamping mechanism is arranged on the lifting table, and the clamping mechanism is provided with a clamping part; the container is arranged in a water bath heating environment, a liquid sample is contained in the container, a container plug is arranged at a container opening, and a through hole is formed in the middle of the container plug; an extraction film clamp is arranged at the bottom of the clamping rod, and scales are further arranged on the clamping rod. According to the invention, the extraction film can penetrate into liquid samples at different positions, is suitable for samples with multiple specifications and volumes, is mainly used for solid-phase micro-extraction operation in chemical analysis experiments, improves the extraction efficiency and accuracy, and reduces experimental errors.

Description

Technical Field

[0001] The present invention relates to the technical field of chemical analysis instruments. More specifically, the present invention relates to a solid-phase microextraction film fixing device for multi-specification liquid sample volumes. Background Art

[0002] In chemical analysis experiments, the thin film solid-phase microextraction (TF-SPME) technology, as an efficient sample pretreatment method, can complete the extraction, purification, and concentration processes of target substances in a short time, and is widely used in fields such as environmental monitoring, food safety, and drug analysis. The key to the TF-SPME technology is to fully contact the extraction film with the sample to achieve effective extraction of the target substance. However, there are many problems with existing solid-phase microextraction film fixing devices.

[0003] First, the adaptability to different specifications of sample volumes is poor. In actual experiments, the volume of samples may vary from dozens of milliliters to thousands of milliliters. Existing fixing devices often can only operate on samples within a specific small volume range and cannot flexibly adapt to various specifications of samples. This results in the need to frequently change containers when dealing with different samples. For example, when analyzing trace pollutants in the water environment, due to the low concentration of pollutants, the film needs to be placed in a large-volume sample for extraction, and existing devices cannot reach large-volume containers.

[0004] Secondly, the stability of the fixing device is insufficient. During the extraction process, it is necessary to ensure that the extraction film is in a stable position to ensure the consistency of the extraction effect. However, some existing devices have unreasonable structural designs. For example, the base is not stable enough, and it is easy to shake due to the water bath, and the extraction film is not firmly fixed. These will all affect the position of the extraction film in the sample and thus affect the accuracy of extraction.

[0005] In addition, the convenience of operation also needs to be improved. When adjusting the position of the extraction film in existing devices, it often requires cumbersome manual operations, such as punching holes in the film with iron wires or thin ropes by oneself and adding weights, etc., to make the film submerged in the water body. This is not only complex in operation but also prone to errors.

[0006] When solving these problems, researchers have tried to improve the performance of the fixing device by improving the design of individual components, such as increasing the weight of the base to improve stability, but this has brought problems such as too large a volume of the device and inconvenience in carrying. Or improving the structure of the clamping mechanism, but due to the lack of an overall system design, the problems of adapting to different specifications of sample volumes and the convenience of operation have not been effectively solved. Summary of the Invention

[0007] The present invention provides a solid-phase microextraction film fixing device for multi-specification liquid sample volumes, which can enable the extraction film to penetrate into liquid samples at different positions, is applicable to multi-specification sample volumes, is mainly used for solid-phase microextraction operations in chemical analysis experiments, improves extraction efficiency and accuracy, and reduces experimental errors.

[0008] To achieve these and other advantages in accordance with the present invention, there is provided a solid-phase microextraction film fixing device for multi-specification liquid sample volumes, comprising: A base; A lifting table (2), which is movably arranged on the base; A power mechanism, which drives the lifting table (2) to move up and down relative to the base; A clamping mechanism, which is arranged on the lifting table (2), and the clamping mechanism has a clamping part; A container (3), which is arranged in a water bath heating environment (1), the container (3) contains a liquid sample inside, there is a container plug at the container mouth, and a through hole is provided in the middle of the container plug; A clamping rod (4), which is vertically arranged and clamped by the clamping part, the clamping rod (4) passes through the through hole and extends into the container (3) inside, an extraction film clip is provided at the bottom of the clamping rod (4), and a scale is also provided on the clamping rod (4).

[0009] Preferably, the base includes: A seat plate (5); A top plate (6), which is arranged above the seat plate (5); A fixing column (7), which is vertically arranged and fixedly installed at the upper end and the lower end on the top plate (6) and the seat plate (5), and a pair of first guide grooves are provided on the two outer sides of the fixing column (7); The lifting table (2) is provided with a pair of first sliders, and when the lifting table (2) moves up and down relative to the base, the pair of first sliders are slidably arranged in the pair of first guide grooves.

[0010] Preferably, the power mechanism includes: A rotating column (8), which is vertically arranged and rotatably installed at the upper end and the lower end on the top plate (6) and the seat plate (5) through bearing seats, and the rotating column (8) is provided with an external thread; A first motor (9), which is arranged on the top plate (6), and the output shaft of the first motor (9) is vertically arranged; A reduction belt pulley group (10), which includes a driving wheel and a driven wheel, the rotating shaft of the driving wheel is driven to rotate by the first motor (9), the rotating shaft of the driven wheel is rotatably installed on the top plate (6) through a bearing seat, and is fixedly connected to the upper end of the rotating column (8); The lifting table (2) is provided with a threaded hole, the internal thread of the threaded hole is matched with the external thread of the rotating column (8), when the rotating column (8) rotates, the lifting table (2) moves up and down relative to the base, and a pair of first sliders are slidably arranged in a pair of first guide grooves.

[0011] Preferably, the clamping mechanism includes: A through groove (10) formed vertically in the lifting table (2); A U-shaped groove (12) formed horizontally in the lifting table (2), the U-shaped groove (12) includes a pair of first notches that penetrate horizontally and a second notch that penetrates longitudinally, and a pair of second guide grooves are oppositely arranged up and down in the second notch; A second motor (13) arranged on the lifting table (2), the output shaft of the second motor (13) is arranged horizontally and extends into the through groove (10) through a bearing connection; A pair of longitudinal translation blocks (14) with a right trapezoidal structure, two second sliders are provided upward and downward near the longer side of the longitudinal translation block (14), when the pair of longitudinal translation blocks (14) move towards each other or move in opposite directions, the four second sliders are slidably arranged in a pair of second guide grooves, and a pair of third guide grooves are oppositely arranged horizontally on the inner sides (i.e., the inclined waists) of the pair of longitudinal translation blocks (14); A transverse translation block (15) with an isosceles trapezoidal structure, the longer side of the transverse translation block (15) is connected to the output shaft of the second motor (13), one third slider is provided on each of the two outer sides of the transverse translation block (15), when the second motor (13) drives the transverse translation block (15) to move horizontally, the two third sliders are slidably arranged in a pair of third guide grooves, and the pair of longitudinal translation blocks (14) move towards each other or move in opposite directions; A pair of L-shaped clamping blocks (16) respectively arranged on the longer sides of the pair of longitudinal translation blocks (14), and the opposite sides of the pair of L-shaped clamping blocks (16) form the clamping part.

[0012] Preferably, it further includes a cover plate mechanism, which includes: A pair of flip plates (17) arranged below the clamping mechanism, the flip plates (17) have semicircular notches, and the notches match the arc of the clamping rod (4); A pair of flip shafts respectively penetrating through the side of the pair of flip plates (17) without the notches in the transverse direction; A connecting rod assembly (19) including a first connecting rod, a second connecting rod, and a third connecting rod that are sequentially hinged, and the ends of the first connecting rod and the third connecting rod are respectively fixedly connected to a pair of flip shafts.

[0013] Preferably, the cover plate mechanism further includes: The third motor (18) has its output shaft horizontally arranged and fixedly connected to one of the flipping shafts.

[0014] Preferably, the contact surface between the extraction film clamp and the extraction film has no teeth.

[0015] The present invention has at least the following beneficial effects: By setting a power mechanism to drive the lifting table (2), the present invention can flexibly adjust the height of the clamping rod (4), and further flexibly adjust the height of the extraction film to adapt to liquid samples at different depths and meet the requirements for sample volumes of multiple specifications. The clamping mechanism can stably clamp the clamping rod (4) to ensure the stability of the extraction film during the extraction process. The scale on the clamping rod (4) facilitates the operator to accurately control the immersion depth of the extraction film, improving the accuracy and repeatability of the experiment.

[0016] Through the split design of the seat plate (5), the top plate (6) and the fixing column (7), and the welding or bolt connection methods adopted between the components, the present invention makes the installation and disassembly of the device more convenient and facilitates maintenance. The fixing column (7), the seat plate (5) and the top plate (6) work together to enhance the rigidity of the entire device, reduce the influence on the extraction process caused by vibration or external impact, and further ensure the stability of the extraction effect. At the same time, it can achieve precise adjustment of the height of the lifting table (2) to meet the requirements for sample volumes of different specifications and different extraction requirements, greatly improving the applicability and flexibility of the device.

[0017] The power mechanism of the present invention realizes speed reduction and torque increase through the reduction belt pulley set (10), making the rotation of the rotating column (8) more stable, and further ensuring the stable lifting movement of the lifting table (2). Combined with the high-precision thread fit and precise control of the motor speed, it can achieve high-precision adjustment of the height of the lifting table (2), with an accuracy of up to 0.1 mm, meeting the requirements for sample volumes of different specifications and different extraction depths, and greatly improving the accuracy and repeatability of extraction. In addition, the design of the reduction belt pulley set (10) enables the motor to be horizontally arranged on the top plate (6). Compared with other power mechanisms, it effectively reduces the space occupied by the device in the vertical direction, making the entire device structure more compact and facilitating use and installation in the limited space of the laboratory.

[0018] Through the ingenious cooperation of the second motor (13), the lateral translation block (15) and the longitudinal translation block (14), the present invention realizes the precise control of the clamping action of the L-shaped clamping block (16). Adopting the transmission mode of the slider-guide groove and cooperating with the high-precision processing technology, it has high transmission efficiency and low energy loss, and can quickly and accurately realize the clamping action. Due to the adjustability of the clamping mechanism, it can adapt to clamping rods (4) of different diameters and shapes, and can clamp the clamping rod (4) at different heights. The components of the clamping mechanism are reasonably arranged, making full use of the space of the lifting platform (2), and making the structure of the whole device more compact.

[0019] By setting the cover plate mechanism, the present invention can effectively prevent the intrusion of external impurities during the extraction process, ensuring the purity of the liquid sample and the accuracy of the extraction result. At the same time, it reduces the volatilization of the liquid sample and maintains the stability of the extraction environment, which is particularly important for the extraction of some volatile target substances, improving the reliability and repeatability of the experiment. Through the transmission of the connecting rod assembly (19), the quick opening and closing of the flip plate (17) is realized, and the operation is simple and convenient. The operator does not need to manually perform cumbersome shielding or protection operations, reducing the interference of human factors on the experiment and improving the experimental efficiency.

[0020] Other advantages, objectives and features of the present invention will be partially reflected by the following description, and partially will also be understood by those skilled in the art through the research and practice of the present invention. Brief Description of the Drawings

[0021] Figure 1 It is a schematic structural diagram of a technical solution of the present invention; Figure 2 It is a schematic structural diagram of the lifting platform of a technical solution of the present invention; Figure 3 It is a schematic structural diagram of the clamping mechanism of a technical solution of the present invention when it is not clamped. Detailed Embodiments

[0022] The following further describes the present invention in detail with reference to the drawings, so that those skilled in the art can implement it according to the description in the specification.

[0023] It should be understood that terms such as "having", "comprising" and "including" used herein do not exclude the presence or addition of one or more other elements or their combinations.

[0024] It should be noted that, unless otherwise specified, the experimental methods described in the following embodiments are all conventional methods, and the reagents and materials, unless otherwise specified, can all be obtained from commercial channels; in the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installation", "connection", and "setting" should be understood in a broad sense. For example, they can be fixedly connected and set, or detachably connected and set, or integrally connected and set. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. The orientation or positional relationship indicated by the terms "horizontal", "vertical", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention.

[0025] As Figures 1 to 3 shown, the present invention provides a solid-phase microextraction film fixing device for multi-specification liquid sample volumes, comprising: A base, which can be made of a high-strength metal material, such as stainless steel, to ensure its stability and durability; A lifting table (2), which is movably arranged on the base. The lifting table (2) and the base can be directly connected (connected in the form of a guide rail slider) or not connected (for example, lifted by the form of a sprocket). Preferably, the lifting table (2) is directly slidably connected to the base, and the guide rail adopts a linear slide rail to ensure the smoothness and accuracy of the movement of the lifting table (2) in the vertical direction. The height of the lifting table (2) can be adjusted to make the extraction film reach a suitable position; A power mechanism, which drives the lifting table (2) to move up and down relative to the base. It can be in the form of a motor or a cylinder, etc. Preferably, an electric screw jack is used, powered by a motor, and through the transmission of a screw-nut pair, the rotational motion of the motor is converted into the linear up-and-down motion of the lifting table (2); A clamping mechanism, which is arranged on the lifting table (2). The clamping mechanism can adopt a double-arm structure, and the opening and closing of the arms are driven by a micro cylinder. By controlling the air pressure in the cylinder, the precise opening and closing of the arms are realized. The clamping mechanism has a clamping part, and an anti-slip rubber pad is installed to increase the friction force and ensure that the clamping rod (4) can be firmly clamped; A container (3), wherein the container (3) is arranged in a water bath heating environment (1), wherein a liquid sample is contained in the container (3), wherein the container (3) may be made of glass or a transparent material such as plastic and having stable chemical properties, so as to facilitate observation of the liquid sample, wherein a container plug is provided at the container mouth, wherein the container plug is made of a suitable material, such as rubber or plastic, and wherein the shape and size of the container plug are matched with the container mouth to ensure that the container mouth can be tightly covered, and wherein a through hole is provided in the middle of the container plug to provide a channel for the installation of subsequent components; A clamping rod (4) is vertically arranged and clamped by the clamping portion. The clamping rod (4) passes through the through hole and extends into the interior of the container (3). An extraction film clamp is provided at the bottom of the clamping rod (4). A flat-mouthed alligator clamp can be used to firmly fix the extraction film to prevent the film from being damaged by the saw teeth. The clamping rod (4) can be applied to various types of films. A scale is also provided on the clamping rod (4) to accurately control the depth of the extraction film in the liquid sample. A 20 cm iron rod can be used, and a small dot can be laser engraved every 1 cm as a scale.

[0026] In the above technical solution, a suitable extraction film is selected according to the volume and properties of the liquid sample and installed on the extraction film clamp. The container (3) containing the liquid sample is placed in a water bath heating device, and the appropriate temperature and heating time are set so that the liquid sample reaches a predetermined temperature. The lifting platform (2) is raised or lowered, and the clamping rod (4) and the extraction film are adjusted to a suitable height, and the extraction film is immersed in the liquid sample. The clamping mechanism is started, and the clamping rod (4) is clamped to ensure that it is stable. After the extraction is completed, the clamping rod (4) is lifted by the power mechanism, and the extraction film is taken out for subsequent analysis and detection.

[0027] In the above technical solution, the extraction film can penetrate into liquid samples at different positions, is applicable to sample volumes of multiple specifications, and is mainly used for solid phase microextraction operations in chemical analysis experiments, thereby improving extraction efficiency and accuracy and reducing experimental errors. Specifically, it has the following beneficial effects: Adaptable to sample volumes of various specifications: By precisely controlling the height of the lifting platform (2), the extraction film can reach a suitable extraction depth in liquid samples of different volumes, thereby more effectively extracting the target substance and improving the extraction efficiency, and is suitable for sample volumes of various specifications.

[0028] Easy to operate: The entire device adopts automatic control. The control system can realize precise control of the power mechanism, clamping mechanism, etc., and can achieve high-precision measurement of the position of the extraction film, reducing the difficulty of operation and labor intensity.

[0029] In another technical solution, the base includes: The seat plate (5) is designed as a rectangular flat plate with a relatively large size, increasing the contact area with the experimental tabletop to enhance stability. Its thickness is determined according to the load-bearing requirements of the entire device and is between 10 - 20 mm. Corresponding mounting holes are also reserved. Rubber feet with adjustable height are installed at the four corners of the bottom of the seat plate (5). On the one hand, it can further improve the anti-slip performance. On the other hand, by adjusting the height of the feet, the device can adapt to experimental tabletops with different flatness levels and bear the weight of the entire device; The top plate (6) is made of the same material as the seat plate (5). It is arranged above the seat plate (5) and is fixed above the seat plate (5) by welding or high-strength bolts. They are kept parallel to each other, providing a stable support point for the fixed column (7). Corresponding mounting holes are also reserved; The fixed column (7) is vertically arranged and its upper and lower ends are fixedly installed on the top plate (6) and the seat plate (5). It is tightly fixed to the top plate (6) and the seat plate (5) by welding or bolts to ensure its vertical stability. A pair of first guide grooves are provided on the two outer sides of the fixed column (7). Preferably, the cross-section of the first guide groove is T-shaped, and the surface of the guide groove is polished to reduce the friction when the lifting table (2) moves; The lifting table (2) is provided with a pair of first sliders. Preferably, the cross-section of the first slider is T-shaped. When the lifting table (2) moves up and down relative to the base, the pair of first sliders slide in a pair of first guide grooves.

[0030] In the above technical solution, the split design of the seat plate (5), the top plate (6) and the fixed column (7), as well as the welding or bolt connection method between the components, make the installation and disassembly of the device more convenient and facilitate maintenance. The fixed column (7), the seat plate (5) and the top plate (6) work together to enhance the rigidity of the entire device, reduce the impact on the extraction process caused by vibration or external force, and further ensure the stability of the extraction effect. At the same time, it can achieve precise adjustment of the height of the lifting table (2), meet the requirements of different sample volumes and different extraction needs, and greatly improve the applicability and flexibility of the device.

[0031] In another technical solution, the power mechanism includes: The rotating column (8) is vertically arranged and its upper and lower ends are rotatably installed on the top plate (6) and the seat plate (5) through high-precision deep groove ball bearing seats. The rotating column (8) is provided with external threads to ensure the matching accuracy with the screw holes of the lifting table (2); The first motor (9) is arranged on the top plate (6). The output shaft of the first motor (9) is vertically arranged. The output shaft of the first motor (9) is connected to the driving wheel of the reduction belt pulley group (10) through a coupling to achieve precise control of the lifting speed of the lifting table (2); The speed-reducing pulley set (10) uses a high-quality rubber belt and pulleys made of aluminum alloy. It includes a driving pulley and a driven pulley. The diameter ratio of the driving pulley and the driven pulley is carefully designed to achieve a suitable speed reduction ratio, ensuring that the lifting platform (2) can be smoothly lifted and lowered at a suitable speed. The rotating shaft of the driving pulley is driven to rotate by the first motor (9). The rotating shaft of the driven pulley is rotatably installed on the top plate (6) through a bearing block and is fixedly connected to the upper end of the rotating column (8), for example, fixed by a key connection, to ensure that the rotating column (8) can be driven to rotate synchronously when the driven pulley rotates; The lifting platform (2) is provided with threaded holes, and the internal threads of the threaded holes cooperate with the external threads of the rotating column (8). When the rotating column (8) rotates, the lifting platform (2) moves up and down relative to the base. A pair of first sliders are slidably arranged in a pair of first guide grooves. When the first motor (9) is started, the rotating column (8) is driven to rotate through the speed-reducing pulley set (10), and the lifting platform (2) makes a smooth up and down movement relative to the base under the action of the threads.

[0032] In the above technical solution, the power mechanism realizes speed reduction and torque increase through the speed-reducing pulley set (10), making the rotation of the rotating column (8) more stable, and thus ensuring the stable up and down movement of the lifting platform (2). Combining high-precision thread fit and precise control of the motor speed, high-precision adjustment of the height of the lifting platform (2) can be achieved, with an accuracy of up to 0.1 mm, meeting the requirements of different sample volumes and different extraction depths, and greatly improving the accuracy and repeatability of extraction. In addition, the design of the speed-reducing pulley set (10) enables the motor to be horizontally arranged on the top plate (6). Compared with other power mechanisms, it effectively reduces the space occupied by the device in the vertical direction, making the entire device structure more compact and facilitating use and installation in the limited space of the laboratory.

[0033] In another technical solution, the clamping mechanism includes: A through groove (10) is formed vertically in the lifting platform (2) for installing a pair of longitudinal translation blocks (14), a transverse translation block (15), the second motor (13) and its output shaft and other components. When the transverse translation block (15) moves closer to or away from the clamping rod (4), it makes a transverse movement along the through groove (10); A U-shaped groove (12) is formed in the lifting table (2) in the horizontal direction. The U-shaped groove (12) includes a pair of first notches that penetrate transversely and a second notch that penetrates longitudinally. The second notch is also provided with a pair of second guiding grooves that are arranged vertically opposite to each other. Preferably, the cross-section of the second guiding groove is T-shaped, and the surface of the guiding groove is polished to reduce the frictional force when a pair of longitudinal translation blocks (14) move. The U-shaped groove (12) communicates with the through groove (10). When the pair of longitudinal translation blocks (14) move towards each other or move in opposite directions, they move longitudinally along the pair of first notches and the second notch. A second motor (13) is arranged on the lifting table (2). The output shaft of the second motor (13) is arranged horizontally and extends into the through groove (10) through a bearing connection. The output shaft of the second motor (13) is rotatably installed on the lifting table (2) through a high-precision deep groove ball bearing. At the same time, the output shaft of the second motor (13) is connected to the transverse translation block (15) through a coupling to achieve precise control of the translation speed of the transverse translation block (15). A pair of longitudinal translation blocks (14) has a right trapezoidal structure. Two second sliders are provided upward and downward at the side of the longitudinal translation block (14) close to the longer side. Preferably, the cross-section of the second slider is T-shaped. When the pair of longitudinal translation blocks (14) move towards each other or move in opposite directions, the four second sliders are slidably arranged in the pair of second guiding grooves with a clearance fit, and the clearance is controlled within 0.05 - 0.1 mm. A pair of third guiding grooves that are horizontally opposite to each other are also provided at the inner side (i.e., the inclined waist) of the pair of longitudinal translation blocks (14). Preferably, the cross-section of the third guiding groove is T-shaped, and the surface of the guiding groove is polished to reduce the frictional force when the transverse translation block (15) moves. A transverse translation block (15) has an isosceles trapezoidal structure. The longer side of the transverse translation block (15) is connected to the output shaft of the second motor (13), preferably through a rigid connection by a coupling to ensure the accuracy of transmission. One third slider is provided on each of the two outer sides of the transverse translation block (15). Preferably, the cross-section of the third slider is T-shaped. When the second motor (13) drives the transverse translation block (15) to move transversely, the two third sliders are slidably arranged in the pair of third guiding grooves, and the pair of longitudinal translation blocks (14) move towards each other or move in opposite directions. A pair of L-shaped clamping blocks (16) are respectively arranged on the longer sides of the pair of longitudinal translation blocks (14) and can be installed by high-precision bolts. The opposite sides of the pair of L-shaped clamping blocks (16) are arranged in parallel to form the clamping part. Teeth can be provided on the surface of the clamping part, or an anti-slip rubber pad can be pasted to further increase the frictional force and ensure firm clamping of the clamping rod (4).

[0034] In the above technical solution, through the ingenious cooperation of the second motor (13), the lateral translation block (15) and the longitudinal translation block (14), the precise control of the clamping action of the L-shaped clamping block (16) is realized. The transmission mode of the slider-guide groove is adopted, combined with a high-precision processing technology, with high transmission efficiency and small energy loss, and the clamping action can be realized quickly and accurately. Due to the adjustability of the clamping mechanism, it can adapt to clamping rods (4) of different diameters and shapes, and can clamp the clamping rod (4) at different heights. The components of the clamping mechanism are reasonably arranged, making full use of the space of the lifting table (2), and making the structure of the whole device more compact.

[0035] In another technical solution, it further includes a cover plate mechanism, which includes: A pair of flip plates (17), which are arranged below the clamping mechanism. The flip plates (17) are designed as rectangles. The flip plates (17) have semi-circular notches, and the notches match the radian of the clamping rod (4). The radius of the notch is customized according to the diameter of the common clamping rod (4) to ensure an accurate match with the radian of the clamping rod (4), and to ensure the shape accuracy and surface roughness of the notch; A pair of flip shafts, which are respectively passed through the side of a pair of flip plates (17) without the notch in the transverse direction. Installation holes are formed by precision drilling. The installation holes and the flip shafts adopt an interference fit to ensure that the flip shafts can rotate flexibly relative to the flip plates (17) without shaking; A connecting rod assembly (19), which includes a first connecting rod, a second connecting rod, and a third connecting rod hinged in sequence. The connecting rods are hinged by pin shafts, and the pin shafts and the hinge holes of the connecting rods adopt a clearance fit to ensure that the connecting rods can rotate flexibly. The first connecting rod and the third connecting rod are of equal length, and the length of the second connecting rod is longer than that of the first connecting rod and the third connecting rod. The ends of the first connecting rod and the third connecting rod are respectively fixedly connected to a pair of flip shafts to ensure that the flip shafts can be driven to rotate synchronously when the connecting rods move. When one flip shaft rotates counterclockwise, the first connecting rod rotates within a small range, pulling the second connecting rod and the third connecting rod to rotate, and pulling the other flip shaft to rotate clockwise at the same speed.

[0036] In the above technical solution, the cover plate mechanism can effectively prevent the intrusion of external impurities during the extraction process, ensuring the purity of the liquid sample and the accuracy of the extraction result. At the same time, it reduces the volatilization of the liquid sample and maintains the stability of the extraction environment, which is particularly important for the extraction of some volatile target substances, improving the reliability and repeatability of the experiment. Through the transmission of the connecting rod assembly (19), the quick opening and closing of the flip plates (17) are realized, and the operation is simple and convenient. The operator does not need to manually perform cumbersome shielding or protection operations, reducing the interference of human factors on the experiment and improving the experimental efficiency.

[0037] In another technical solution, the cover plate mechanism further includes: The third motor (18) has its output shaft horizontally arranged and fixedly connected to one of the flipping shafts. The output shaft of the third motor (18) is connected to a flipping shaft through a coupling to achieve precise control of the flipping speed and angle of the flipping shaft.

[0038] In the above technical solution, the third motor (18) drives one flipping shaft to rotate, drives the connecting rod assembly (19) to rotate, and drives the other flipping shaft to rotate, so as to achieve the rapid opening and closing and precise opening and closing of the flipping plate (17).

[0039] In another technical solution, the contact surface between the extraction film clip and the extraction film does not have teeth. The extraction film clip uses a smooth plane as the contact surface with the extraction film, avoiding the use of a toothed structure. The extraction film will not be damaged due to the toothed structure of the contact surface, which can ensure the integrity of the extraction film, extend the service life of the extraction film, and reduce the experimental cost.

[0040] The number of devices and the processing scale described here are used to simplify the description of the present invention. The application, modification, and variation of the present invention will be obvious to those skilled in the art.

[0041] Although the embodiments of the present invention have been disclosed as above, it is not limited to only the applications listed in the specification and the embodiments. It can be fully applied to various fields suitable for the present invention. For those familiar with the field, additional modifications can be easily achieved. Therefore, without departing from the general concept defined by the claims and the equivalent scope, the present invention is not limited to the specific details and the illustrated examples here.

Claims

1. A solid phase microextraction film fixing device for liquid sample volumes of multiple specifications, characterized in that: Comprising: Base; Lifting platform (2), which is movably arranged on the base; Power mechanism, which drives the lifting platform (2) to move up and down relative to the base; Clamping mechanism, which is arranged on the lifting platform (2), and the clamping mechanism has a clamping part; Container (3), which is arranged in a water bath heating environment (1), the container (3) contains a liquid sample inside, and there is a container plug at the container mouth, and a through hole is provided in the middle of the container plug; Clamping rod (4), which is vertically arranged and clamped by the clamping part, the clamping rod (4) passes through the through hole and extends into the container (3) internally, an extraction film clip is provided at the bottom of the clamping rod (4), and a scale is also provided on the clamping rod (4).

2. The solid phase microextraction film fixing device for multi-standard liquid sample volumes as claimed in claim 1, characterized in that: The base includes: Seat plate (5); Top plate (6), which is arranged above the seat plate (5); Fixed column (7), which is vertically arranged and fixedly installed at the upper end and the lower end on the top plate (6) and the seat plate (5), and a pair of first guide grooves are provided on the two outer sides of the fixed column (7); The lifting platform (2) is provided with a pair of first sliders, and when the lifting platform (2) moves up and down relative to the base, the pair of first sliders are slidably arranged in the pair of first guide grooves.

3. The solid phase microextraction film fixing device for liquid sample volumes of multiple specifications as claimed in claim 2, characterized in that: The power mechanism includes: Rotating column (8), which is vertically arranged and rotatably installed at the upper end and the lower end on the top plate (6) and the seat plate (5) through bearing seats, and the rotating column (8) is provided with an external thread; First motor (9), which is arranged on the top plate (6), and the output shaft of the first motor (9) is vertically arranged; Reduction belt pulley set (10), which includes a driving wheel and a driven wheel, the rotating shaft of the driving wheel is driven to rotate by the first motor (9), the rotating shaft of the driven wheel is rotatably installed on the top plate (6) through a bearing seat, and is fixedly connected to the upper end of the rotating column (8); The lifting platform (2) is provided with a screw hole, and the internal thread of the screw hole is matched with the external thread of the rotating column (8). When the rotating column (8) rotates, the lifting platform (2) moves up and down relative to the base, and a pair of first sliders are slidably arranged in a pair of first guide grooves.

4. The solid phase microextraction film fixing device for liquid sample volumes of multiple specifications as claimed in claim 1, characterized in that: The clamping mechanism includes: Through groove (10), which is formed in the lifting platform (2) along the vertical direction; C-shaped groove (12), which is formed in the lifting platform (2) along the horizontal direction, the C-shaped groove (12) includes a pair of first notches that penetrate horizontally and a second notch that penetrates longitudinally, and a pair of second guide grooves are also provided on the second notch and are arranged opposite to each other up and down; Second motor (13), which is arranged on the lifting platform (2), the output shaft of the second motor (13) is horizontally arranged and extends into the through groove (10) through a bearing connection; A pair of longitudinal translation blocks (14), which are in a right trapezoidal structure, and two second sliders are provided upward and downward at the side of the longitudinal translation block (14) close to the longer side. When the pair of longitudinal translation blocks (14) move towards each other or move in the opposite direction, the four second sliders are slidably arranged in the pair of second guide grooves, and a pair of third guide grooves are also provided horizontally and opposite to each other on the inner sides (i.e., the inclined waists) of the pair of longitudinal translation blocks (14); a transverse translation block (15) having an isosceles trapezoidal structure, wherein a longer side of the transverse translation block (15) is connected to an output shaft of the second motor (13), and a third slider is provided on each of two outer sides of the transverse translation block (15); when the second motor (13) drives the transverse translation block (15) to move transversely, two third sliders are slidably arranged in a pair of third guide grooves, and a pair of longitudinal translation blocks (14) move towards each other or in opposite directions; A pair of L-shaped clamping blocks (16) are respectively arranged on the longer side of the pair of longitudinal translation blocks (14), and the opposite sides of the pair of L-shaped clamping blocks (16) form the clamping portion.

5. The solid phase microextraction film fixing device for liquid sample volumes of multiple specifications as claimed in claim 1, characterized in that: Also included is a cover mechanism, which includes: a pair of flip plates (17) disposed below the clamping mechanism, the flip plates (17) having a semicircular notch, the notch matching the arc of the clamping rod (4); A pair of turning shafts, each of which is laterally penetrated through a side of a pair of turning plates (17) where the notch is not provided; The connecting rod assembly (19) comprises a first connecting rod, a second connecting rod, and a third connecting rod which are hinged in sequence, wherein the ends of the first connecting rod and the third connecting rod are respectively fixedly connected to a pair of tilting shafts.

6. The solid phase microextraction film fixing device for liquid sample volumes of multiple specifications as claimed in claim 5, characterized in that: The cover mechanism also includes: The output shaft of the third motor (18) is arranged horizontally and is fixedly connected to one of the flip shafts.

7. The solid phase microextraction film fixing device for liquid sample volumes of multiple specifications as claimed in claim 1, characterized in that: The contact surface of the extraction membrane clamp with the extraction membrane has no teeth.

Images