Donor faeces sample low-oxygen collection box and device

Abstract

The invention discloses a low-oxygen collection box and device for a donor excrement sample, and relates to the technical field of biomedicine. The box body is internally provided with a sample collecting cavity, the box cover is connected with the box body, the side, close to the box body, of the box cover is connected with a containing groove, and a deoxidizing agent bag capable of reducing the oxygen content in the sample collecting cavity is placed in a containing cavity of the containing groove. A vent hole communicated with the accommodating cavity and the sample collecting cavity is formed in the accommodating groove. According to the invention, the excrement sample can be in a low-oxygen environment, so that the survival rate of anaerobic bacteria in the excrement sample is improved.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technologies, and particularly relates to a hypoxic collection box and device for donor fecal samples. Background Art

[0002] Fecal Microbiota Transplantation (FMT) is a technique that transplants the fecal microbiota of healthy donors into the intestines of patients after processing to reconstruct the microbiota balance and achieve the treatment of intestinal and extra-intestinal diseases; as an innovative treatment method, it was officially included in the "Notice on Issuing the Technical Specifications for National Medical Service Items" issued by the National Health Commission in 2023.

[0003] Before the implementation of the fecal microbiota transplantation technique (FMT), it is necessary to maintain the microbiota diversity and relative abundance of beneficial intestinal bacteria in the fecal sample as much as possible to improve the treatment effect of the fecal microbiota transplantation technique (FMT).

[0004] After research and analysis, it is found that the vast majority of beneficial intestinal bacteria are anaerobic bacteria. Although the existing fecal sample collectors can collect fecal samples more conveniently, their own effect on maintaining the microbiota diversity and relative abundance of anaerobic bacteria in the fecal sample is poor, and the survival rate of anaerobic bacteria in the fecal sample is low. Therefore, it is necessary to improve this. Summary of the Invention

[0005] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a hypoxic collection box and device for donor fecal samples to improve the survival rate of anaerobic bacteria in the fecal sample.

[0006] To achieve the above purpose, the technical solutions designed by the present invention are as follows:

[0007] In a first aspect, the present invention provides a hypoxic collection box for donor fecal samples, including a box body with a sample collection cavity inside and a box cover connected to the box body. A storage groove is connected to the side of the box cover close to the box body. A deoxidizer packet that can reduce the oxygen content in the sample collection cavity is placed in the storage cavity of the storage groove, and a ventilation hole communicating the storage cavity and the sample collection cavity is provided on the storage groove.

[0008] In the above technical solution, a plurality of support feet are provided at the lower end of the box body.

[0009] In the above technical solution, a support foot groove corresponding to the support feet is provided on the box cover.

[0010] In the above technical solution, the plurality of support feet include first support feet located on both sides of the box body and second support feet located in the middle of the box body. The cross-section of the first support feet in the horizontal direction is in the shape of a '7', and the cross-section of the second support feet in the horizontal direction is in the shape of a straight line.

[0011] In the above technical solution, a pull ring is connected to the box cover.

[0012] In the above technical solution, the pull ring and the box cover are of an integral structure, and the pull ring is located in the middle of the arc-shaped edge of the box cover.

[0013] In the above technical solution, an outer lip is connected to the top edge of the box body, and an inner groove corresponding to the outer lip is provided at the edge of the box cover.

[0014] In the above technical solution, a label for realizing the function of sample traceability is provided on the box body and / or the box cover.

[0015] In the above technical solution, the box body is made of a hard transparent material, and the box cover is made of a soft material.

[0016] In the above technical solution, the box body is made of a hard material, and the box cover is made of a soft material; and / or, the cross-sections of the box body and the box cover in the horizontal direction are both semi-elliptical.

[0017] In the above technical solution, a plurality of reinforcing ribs are connected to the outer wall of the box body; and / or, a desiccant packet for removing the fog inside the box body is further provided in the storage groove.

[0018] In the above technical solution, the storage groove and the box cover are connected together by a snap structure, and the opening direction of the storage cavity in the storage groove faces the box cover.

[0019] In the above technical solution, the storage groove and the box cover are of an integral structure, and a deoxidation port for taking and placing the deoxidant packet is provided on the storage groove.

[0020] In a second aspect, the present invention further provides a low-oxygen collection device for donor fecal samples, including a toilet and the low-oxygen collection box for donor fecal samples as described above. A toilet bowl for placing the low-oxygen collection box for donor fecal samples is provided on the toilet.

[0021] In the above technical solution, the toilet has a handrail; and / or, the shape of the inner wall at the rear end of the toilet bowl matches the shape of the outer wall of the box body, and a cavity is formed between the front end of the toilet bowl and the outer wall of the box body.

[0022] Advantages of the present invention:

[0023] 1. The box body and the box cover can be hermetically connected together. The box body can be made of a rigid transparent material (such as PEP plastic), and the box cover can be made of a soft material (such as latex). The fecal sample can be placed in the sample collection cavity. After the box body and the box cover are connected together, the deoxidizer packet will absorb the oxygen in the sample collection cavity through the ventilation hole to reduce the oxygen content in the sample collection cavity, thereby increasing the survival rate of anaerobic bacteria in the fecal sample and better protecting the fecal sample. The desiccant packet can remove the fog in the box body so that people can directly view the fecal sample in the box body, making the present application more convenient to use.

[0024] 2. The support feet and the foot slots can not only make it more convenient to place the low-oxygen collection box for donor fecal samples on the ground, toilet, table or test bench, making the present application more convenient to use, but also make it possible to stack multiple low-oxygen collection boxes for donor fecal samples more firmly together, thereby improving the structural stability of the present application.

[0025] 3. The pull ring can be used to separate the box body and the box cover, making the present application more convenient to use. At the same time, the present application provides two ways to connect the storage groove and the box cover, and people can conveniently place the deoxidizer packet in the storage groove, so that the fecal sample is in a low-oxygen environment, thereby increasing the survival rate of anaerobic bacteria in the fecal sample.

[0026] 4. Under the combined action of the above-mentioned toilet and the low-oxygen collection box for donor fecal samples, people can collect fecal samples more conveniently. At the same time, the present application can store fecal samples for a long time. When long-term storage of fecal samples is required, the present application only needs to be placed in the freezer (-20°C) of the refrigerator.

[0027] 5. The outer lip and the inner groove can further enhance the sealing performance between the box body and the box cover, so that the sample collection cavity described in the present application can maintain a low-oxygen state for a longer time, which can not only further increase the survival rate of anaerobic bacteria in the feces, but also extend the storage time of fecal samples in the freezer.

[0028] 6. The low-oxygen collection device for fecal samples can assist people in collecting fecal samples. The handrail can make it more convenient for people to stand up or sit on the toilet. The cavity formed between the inner wall of the front end of the toilet bowl and the outer wall of the box body can separate urine and feces to make the fecal sample drier, so that the low-oxygen collection box for donor fecal samples (containing fecal samples inside) is easier to preserve and transport, making the present application more convenient to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 is a schematic structural diagram of the low-oxygen collection box for donor fecal samples described in the present application from the first perspective;

[0030] Figure 2Schematic diagram of the low-oxygen collection box for the donor fecal sample described in this application from the second perspective;

[0031] Figure 3 is Figure 1 Schematic diagram of the structure without the box cover;

[0032] Figure 4 Schematic diagram of the connection structure between the box cover and the storage groove;

[0033] Figure 5 Schematic diagram of the structure of the toilet.

[0034] In the figure: 1. Box body; 11. Sample collection cavity; 12. Outer lip; 2. Box cover; 3. Storage groove; 31. Storage cavity; 32. Ventilation hole; 4. Deoxidizer packet; 5. Support feet; 51. First support foot; 52. Second support foot; 6. Foot slot; 71. Pull ring; 72. Reinforcing rib; 8. Snap structure; 9. Toilet; 91. Toilet bowl; 92. Armrest. Detailed implementation manners

[0035] The following further describes the present invention in detail with specific embodiments for those skilled in the art to understand.

[0036] Shortly after a newborn is born, a large number of external microorganisms begin to attach to its body surface and intestines. Most of these microorganisms adapt to the human body and finally form a symbiotic relationship that accompanies the human body throughout life. Among these symbiotic microorganisms, about 100 trillion intestinal microorganisms will colonize the human intestine. This intestinal microbiota covers various microorganisms such as bacteria, fungi, and viruses. The genome of the intestinal microbiota contains about 5 million genes, which is about 150 times the number of human genes. Due to its huge quantity and rich variety characteristics, the intestinal microbiota is called the "second gene bank" of the human body. It is the most complex and largest microecosystem in the human body and is known as the eighth organ of the human body.

[0037] The technology of fecal microbiota transplantation (FMT) originated from the works "Elbow Emergency Prescriptions" in the Eastern Jin Dynasty and "Plain Questions" in the Spring and Autumn Period and the Warring States Period. Traditional Chinese medicine used human feces (recorded as Huanglong Decoction / Jinzhi) to treat intestinal diseases. In 1958, surgeon Eiseman used human fecal enema to treat patients with pseudomembranous colitis. In 2013, the American medical guidelines announced that human feces can be used for the treatment of Clostridium difficile.

[0038] At present, fecal microbiota transplantation (FMT) technology has shown significant efficacy in the treatment of gastrointestinal diseases such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), recurrent Clostridioides difficile infection (CDI), ulcerative colitis (UC), functional constipation (FC), etc. With the in-depth research and continuous updates in technical aspects such as high-throughput sequencing, artificial intelligence big data analysis, and intelligent production systems, its clinical application cases are also increasing continuously, showing broad application prospects.

[0039] Before the implementation of fecal microbiota transplantation (FMT) technology, it is necessary to isolate and collect the intestinal microbiota in the fecal donor. Before that, people need to maintain the microbial diversity and relative abundance of beneficial intestinal bacteria in the fecal sample as much as possible to improve the therapeutic effect of fecal microbiota transplantation (FMT) technology.

[0040] After research and analysis, it is found that most of the beneficial intestinal bacteria are anaerobic bacteria. Although the existing fecal sample collectors can collect fecal samples more conveniently, their effect on maintaining the microbial diversity and relative abundance of anaerobic bacteria in the fecal sample is poor, and the survival rate of anaerobic bacteria in the fecal sample will be lower. Therefore, it is necessary to improve this.

[0041] In view of the above problems, on the one hand, as Figure 1 shown, the present invention provides a low-oxygen collection box for donor fecal samples, which includes a box body 1 with a sample collection chamber 11 arranged inside and a box cover 2 connected to the box body 1. A storage groove 3 is connected to the box cover 2 on the side close to the box body 1. A deoxidizer packet 4 that can reduce the oxygen content in the sample collection chamber 11 is placed in the storage chamber 31 of the storage groove 3, and a ventilation hole 32 communicating the storage chamber 31 and the sample collection chamber 11 is provided on the storage groove 3.

[0042] During actual work, the box body 1 and the box cover 2 can be hermetically connected together. The box body 1 can be made of a rigid transparent material (such as PEP plastic), and the box cover 2 can be made of a soft material (such as latex) so that people can directly view the fecal sample in the box body, making the application of this application more convenient.

[0043] The fecal sample can be placed in the sample collection chamber 11. After the box body 1 and the box cover 2 are connected together, the deoxidizer packet 4 will absorb the oxygen in the sample collection chamber 11 through the ventilation hole 32 to reduce the oxygen content in the sample collection chamber 11, thereby increasing the survival rate of anaerobic bacteria in the fecal sample and better protecting the sample.

[0044] As Figure 2 shown, a plurality of support feet 5 are arranged at the lower end of the box body 1. The above support feet 5 can not only support the box body 1, but also prevent the bottom of the box body 1 from directly contacting the tabletop or the ground, making the application of this application more convenient, cleaner and more hygienic.

[0045] The plurality of the support feet 5 include a first support foot 51 located on both sides of the box body 1 and a second support foot 52 located in the middle of the box body 1. The cross-section of the first support foot 51 along the horizontal direction is in the shape of a "7", and the cross-section of the second support foot 52 along the horizontal direction is in the shape of a "one". In this way, under the combined action of the first support and the second support foot 52, the structural stability of the present application is higher.

[0046] A support foot groove 6 corresponding to the support foot 5 is provided on the box cover 2. In this way, under the combined action of the support foot groove 6 and the support foot 5, a plurality of low-oxygen collection boxes for donor fecal samples can be stacked more firmly together, and its structural stability is higher.

[0047] A pull ring 71 is connected to the box cover 2. In this way, people can separate the box body 1 and the box cover 2 through the pull ring 71, making the present application more convenient to use.

[0048] A label (not shown in the figure) for realizing the function of sample traceability is provided on the box body 1 and / or the box cover 2. The label can be a two-dimensional code and / or a bar code, which can make it more convenient to realize the function of donor traceability for the present application. Preferably, each donor is separately configured with a label (such as a two-dimensional code), so as to facilitate the management of donor fecal samples.

[0049] As Figure 2 and Figure 4 shown, the cross-sections of the box body 1 and the box cover 2 along the horizontal direction are both semi-elliptical. In this way, the box body 1 and the box cover 2 of the present application can match the shape of the toilet bowl 91 in the mainstream toilet 9 on the market, making the present application more convenient to use.

[0050] In order to further increase the structural stability of the present application, a plurality of reinforcing ribs 72 are connected to the outer wall of the box body 1.

[0051] An outer lip 12 is connected to the top edge of the box body 1, and an inner groove corresponding to the outer lip 12 is provided at the edge of the box cover 2. The above-mentioned outer lip 12 and inner groove can further enhance the sealing performance between the box body 1 and the box cover 2, so that the sample collection cavity 11 of the present application can maintain a low-oxygen state for a longer time, in order to improve the survival rate of anaerobic bacteria in feces.

[0052] Preferably, the length of the above-mentioned outer lip 12 is 2-4 mm (preferably 4 mm). The outer lip 12 with a longer length can further enhance the sealing performance between the box body 1 and the box cover 2, thereby further improving the survival rate of anaerobic bacteria in feces; further, the wall thickness of the box body 1 is 2-3 mm (preferably 2.5 mm), so that the structural stability of the present application is higher and the service life is longer.

[0053] During actual operation, the storage slot 3 and the box cover 2 can be connected together in various ways, as long as the deoxidizer packet 4 can be placed in the storage slot 3. For example:

[0054] 1) As Figure 4 described, the storage slot 3 and the box cover 2 are connected together through a snap structure 8, and the opening direction of the storage cavity 31 in the storage slot 3 faces the box cover 2. Preferably, the snap structure 8 includes a snap block provided on the box cover 2, a flanging is provided at the top of the storage slot 3, and a slot corresponding to the flanging is provided in the snap block. The storage slot 3 and the box cover 2 are detachably connected together through the above-mentioned snap block, flanging and slot.

[0055] The present application realizes the first way of connecting the storage slot 3 and the box cover 2. The snap structure 8 can enable a detachable connection between the storage slot 3 and the box cover 2. After people detach the storage slot 3 from the box cover 2, the deoxidizer packet 4 and the desiccant packet can be placed in the storage slot 3.

[0056] 2) The storage slot 3 and the box cover 2 are of an integral structure, and a deoxidation port (not shown in the figure) for taking in and out the deoxidizer packet 4 is provided on the storage slot 3. In this way, the present application also realizes the second way of connecting the storage slot 3 and the box cover 2. The deoxidation port allows people to directly insert the deoxidizer packet 4 into the storage slot 3.

[0057] In a second aspect, the present application further provides a low-oxygen collection device for donor fecal samples, including a toilet 9 and the donor fecal sample low-oxygen collection box described above. A toilet bowl 91 for placing the donor fecal sample low-oxygen collection box is provided on the toilet 9.

[0058] With the combined action of the above-mentioned toilet 9 and the donor fecal sample low-oxygen collection box, people can collect fecal samples more conveniently. For the specific description of the above-mentioned fecal sample low-oxygen collection device, reference can be made to the specific description of the above-mentioned donor fecal sample low-oxygen collection box. To avoid repetition, it will not be elaborated here one by one.

[0059] Furthermore, there is a handrail 92 on the toilet 9. The shape of the inner wall of the toilet bowl 91 matches the shape of the outer wall of the box body 1, and a cavity is formed between the inner wall at the front end of the toilet bowl 91 and the outer wall of the box body 1. The fecal sample low-oxygen collection device can assist people in collecting fecal samples. The handrail enables people to stand up or sit on the toilet more conveniently. The cavity formed between the inner wall at the front end of the toilet bowl and the outer wall of the box body can separate urine and feces, so that the fecal sample is drier, making it easier to preserve and transport the donor fecal sample low-oxygen collection box (containing fecal samples inside), and thus making the present application more convenient to use.

[0060] Other parts not described in detail are all prior arts. Although the above embodiments have described the present invention in detail, they are only some embodiments of the present invention, rather than all embodiments. People can also obtain other embodiments based on these embodiments without creative efforts, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A hypoxia collection kit for fecal samples from donors, characterized in that: The invention comprises a box body (1) having a sample collecting chamber (11) disposed therein and a box cover (2) connected to the box body (1); the box cover (2) is connected to a storage groove (3) on a side close to the box body (1); a storage chamber (31) of the storage groove (3) contains a deoxidizer bag (4) capable of reducing the oxygen content in the sample collecting chamber (11); and a vent hole (32) is disposed on the storage groove (3) for connecting the storage chamber (31) and the sample collecting chamber (11).

2. The hypoxia collection kit for fecal samples of donors according to claim 1, characterized in that: A plurality of supporting legs (5) are provided at the lower end of the box body (1).

3. The hypoxia collection kit for fecal samples of donors according to claim 2, characterized in that: The box cover (2) is provided with a support foot groove (6) corresponding to the support foot (5).

4. The hypoxia collection kit for donor feces sample according to claim 3, characterized in that: The plurality of supporting legs (5) include first supporting legs (51) located at both sides of the box body (1) and second supporting legs (52) located in the middle of the box body (1); the cross section of the first supporting legs (51) along the horizontal direction is a 7-shaped cross section, and the cross section of the second supporting legs (52) along the horizontal direction is a straight-line cross section.

5. The donor stool sample hypoxia collection kit according to any one of claims 1 to 4, characterized in that: The box cover (2) is connected with a pull ring (71).

6. The hypoxia collection kit for donor feces sample according to claim 5, characterized in that: The pull ring (71) and the box cover (2) are of an integrated structure, and the pull ring (71) is located in the middle of the arc-shaped arch edge of the box cover (2).

7. The hypoxia collection kit for fecal samples of donors according to claim 5, characterized in that: An outer lip (12) is connected to the top edge of the box body (1), and an inner groove corresponding to the outer lip (12) is provided at the edge of the box cover (2).

8. The hypoxia collection kit for fecal samples of donors according to claim 5, characterized in that: The box body (1) and / or the box cover (2) are provided with a label for realizing the sample traceability function.

9. The hypoxia collection kit for fecal samples of donors according to claim 5, characterized in that: The box body (1) is made of a hard transparent material, and the box cover (2) is made of a soft material; and / or the cross-sections of the box body (1) and the box cover (2) along the horizontal direction are both semi-elliptical.

10. The hypoxia collection kit for fecal samples of donors according to claim 5, characterized in that: A plurality of reinforcing ribs (72) are connected to the outer wall of the box body (1); and / or the storage groove (3) is further provided with a desiccant bag for removing mist in the box body (1).

11. The hypoxia collection kit for fecal samples of donors according to claim 5, characterized in that: The storage groove (3) and the box cover (2) are an integrated structure, and the storage groove (3) is provided with a deoxidation port for taking in and placing the deoxidizer package (4).

12. The hypoxia collection kit for fecal samples of donors according to claim 5, characterized in that: The storage groove (3) and the box cover (2) are connected together via a snap-fit ​​structure (8), and the opening direction of the storage cavity (31) in the storage groove (3) faces the box cover (2).

13. A hypoxic collection device for fecal samples from donors, characterized in that: It comprises a toilet (9) and a hypoxia collection box for feces samples of donors as claimed in any one of claims 1 to 12, wherein the toilet (9) is provided with a toilet seat (91) for placing the hypoxia collection box for feces samples of donors.

14. The donor stool sample hypoxia collection device according to claim 13, characterized in that: The toilet (9) is provided with a handrail (92); and / or the shape of the inner wall at the rear end of the toilet bowl (91) matches the shape of the outer wall of the box body (1), and a cavity is formed between the inner wall at the front end of the toilet bowl (91) and the outer wall of the box body (1).

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