Lubricating oil for medical equipment and preparation method thereof

Abstract

The invention discloses lubricating oil for medical equipment and a preparation method of the lubricating oil, and particularly relates to the technical field of lubricating oil, the lubricating oil comprises 5%-15% of modified nano silicon dioxide dispersion liquid, 30%-50% of plant-based polyol ester, 0.5%-3% of biodegradable antioxidant, 0.01%-0.1% of fluorocarbon surfactant and 0.005%-0.02% of polyether modified organic silicon defoamer, and the balance is mineral base oil treated by a special removal process. The modified nano silicon dioxide dispersion liquid is modified by a silane coupling agent, the average particle size is 5-20 nanometers, and the wear resistance and the thermal stability can be enhanced. The plant-based polyol ester is good in biodegradability and low in volatility. The biodegradable antioxidant is compounded by tocopherol and tea polyphenol, and is environment-friendly and free of adverse effects. And the spreadability and wettability are improved by the fluorocarbon surfactant. The preparation method comprises the steps of raw material pretreatment, preliminary mixing, dispersion strengthening, additive addition, detection and packaging and the like, and the prepared lubricating oil has excellent lubrication, stability, environmental protection and safety performance and is suitable for medical equipment.

Description

Technical Field

[0001] The present invention relates to the technical field of lubricating oils, and more specifically, to lubricating oils for medical equipment and a preparation method thereof. Background Art

[0002] In the modern medical system, the stable operation and safety of medical equipment play a decisive role in the quality of medical services. As a key maintenance material for medical equipment, the performance of lubricants is directly related to the service life, operating accuracy and diagnosis and treatment experience of the equipment. However, the lubricants currently used in medical equipment have significant deficiencies in many aspects and are difficult to meet the growing needs of the medical industry.

[0003] From the perspective of lubrication performance, traditional lubricants are difficult to provide continuous and stable lubrication for medical equipment under complex working conditions. Some medical equipment, such as high-precision surgical instruments and imaging equipment, have extremely high requirements for lubrication, requiring lubricants to have extremely low friction coefficients and excellent wear resistance. However, after long-term use, traditional lubricants are prone to problems such as lubricating film rupture and increased wear, resulting in reduced equipment operating accuracy, which not only affects the accuracy of diagnostic results, but may also cause harm to patients during surgery.

[0004] In terms of biosafety, existing lubricants also have many hidden dangers. Many common lubricants contain chemicals that are harmful to the human body, such as heavy metals and aromatics. When these lubricants are used in medical devices that have a risk of contact with the human body, harmful substances may enter the human body through direct contact, volatilization, etc., causing adverse reactions such as allergies and poisoning, seriously threatening the health of patients and medical staff. Moreover, some lubricants may undergo chemical changes during the high-temperature and high-pressure sterilization process of medical equipment, producing new harmful substances, further increasing safety risks.

[0005] From an environmental perspective, traditional lubricants have poor biodegradability. With the increasing awareness of environmental protection and increasingly stringent regulations, the medical industry has higher and higher environmental requirements for lubricants. The large-scale use of lubricants that are difficult to biodegrade will cause environmental pollution during equipment maintenance and scrapping, which is not in line with the concept of sustainable development.

[0006] In addition, the stability of traditional lubricants faces severe challenges in the special operating environment of medical equipment, such as high humidity and strong electromagnetic interference. In a high humidity environment, lubricants easily absorb moisture, resulting in faster oxidation and reduced lubrication performance; in a strong electromagnetic interference environment, some lubricants may have abnormal performance, affecting the normal operation of the equipment. With the rapid development of medical technology, new medical equipment continues to emerge, which puts higher and more complex requirements on the performance of lubricants. The limitations of traditional lubricants in many aspects need to be overcome urgently.

[0007] Therefore, a lubricating oil for medical equipment and its preparation method are proposed herein. Summary of the Invention

[0008] In order to overcome the above-mentioned defects of the prior art, the present invention provides a lubricating oil for medical equipment and its preparation method to solve the problems raised in the above-mentioned background art.

[0009] To achieve the above object, the present invention provides the following technical solution: A lubricating oil for medical equipment, comprising components in the following weight percentages: 5%-15% of a modified nano-silica dispersion, 30%-50% of a plant-based polyol ester, 0.5%-3% of a biodegradable antioxidant, 0.01%-0.1% of a fluorocarbon surfactant, 0.005%-0.02% of a polyether-modified silicone defoamer, and the balance being a mineral base oil treated by a special removal process. The modified nano-silica dispersion is prepared by surface-modifying nano-silica with a silane coupling agent and uniformly dispersing it in a specific organic solvent, with an average particle size between 5 and 20 nanometers, which can effectively enhance the wear resistance and load-carrying capacity of the lubricating oil while improving its thermal stability.

[0010] Preferably, the plant-based polyol ester is prepared by an esterification reaction of natural vegetable oil and polyol, and its unsaturated bond content is less than 5%, and the degree of branching is between 10% and 30%. This makes the ester not only have good lubricating performance, but also excellent biodegradability and low volatility, meeting the strict requirements of medical equipment for environmental protection and safety.

[0011] Preferably, the biodegradable antioxidant is a compound of tocopherol (vitamin E) and tea polyphenols, and the weight ratio of the two is (1-3):(1-2). This compound antioxidant can effectively inhibit the oxidation of the lubricating oil while rapidly degrading in the natural environment, greatly reducing environmental pollution and having no adverse effects on the human body and medical equipment.

[0012] Preferably, the fluorocarbon surfactant contains a perfluoroalkyl chain in its molecular structure, and its hydrophobic and oleophobic properties are excellent, which can significantly reduce the surface tension of the lubricating oil, making it have better spreading and wetting properties on the surface of medical equipment, thereby improving the lubricating effect and protective performance.

[0013] Preferably, the ratio of the polyether chain segment to the silicone chain segment of the polyether-modified silicone defoamer is (2-4):(1-3). This structural design enables it to defoam while being well compatible with other components in the lubricating oil and not causing phase separation, ensuring the stability of the lubricating oil under complex working conditions.

[0014] Preferably, the mineral base oil is treated by a dual process of hydroisomerization dewaxing and adsorption refining, with a sulfur content of less than 10 ppm, a nitrogen content of less than 5 ppm, and an aromatic content of less than 1%, which effectively improves the oxidation stability, low-temperature fluidity and cleaning performance of the base oil and reduces the potential damage of impurities to medical equipment.

[0015] A method for preparing the above-mentioned lubricating oil for medical equipment comprises the following steps:

[0016] Raw material pretreatment: Surface modification of nano-silicon dioxide to prepare modified nano-silicon dioxide dispersion; vacuum dehydration of plant-based polyol ester to remove water and low-boiling impurities; hydroisomerization dewaxing and adsorption refining of mineral base oil;

[0017] Preliminary mixing: Add the treated mineral base oil into the reactor, heat it to 50-70°C, and stir it at a stirring speed of 150-350r / min for 15-30 minutes to make the temperature uniform; add plant-based polyol ester and biodegradable antioxidant in sequence, and continue stirring for 30-60 minutes to form a preliminary mixed solution;

[0018] Dispersion enhancement: Add modified nano-silicon dioxide dispersion to the preliminary mixed solution, start the high-speed disperser, and disperse at a speed of 1000-3000r / min for 30-60 minutes to evenly disperse the nanoparticles in the mixed solution;

[0019] Adding additives: Control the temperature of the reactor at 60-80°C, add fluorocarbon surfactant and polyether modified silicone defoamer, and stir at a stirring speed of 200-400r / min for 20-40 minutes;

[0020] Testing and packaging: The prepared lubricants are subjected to comprehensive quality testing, including testing of biocompatibility, lubrication performance, stability and other indicators; after passing the test, they are packaged in a 10,000-level dust-free, fully enclosed environment that is dual-sterilized with ultraviolet light and ozone.

[0021] Preferably, in the raw material pretreatment stage, the modified nano-silicon dioxide dispersion is subjected to ultrasonic dispersion treatment, with an ultrasonic frequency of 30-50 kHz, an ultrasonic power of 200-500 W, and an ultrasonic time of 20-40 minutes, so as to further refine the particle size and improve its dispersion uniformity.

[0022] Preferably, in the dispersion enhancement stage, a high-pressure homogenizer is used to treat the mixed liquid, the homogenization pressure is 50-100 MPa, and the treatment is circulated 2-4 times to ensure that the modified nano-silicon dioxide reaches a nano-scale dispersion level in the lubricating oil and fully exerts its performance enhancement effect.

[0023] Technical effects and advantages of the present invention:

[0024] 1. The average particle size of the modified nano-silica dispersion is 5 - 20 nm, which can effectively enhance the wear resistance and load-carrying capacity of the lubricating oil, improve the lubrication effect, reduce the wear of medical device components, extend the service life of the device. The plant-based polyol ester has good lubrication performance, with an unsaturated bond content of less than 5% and a degree of branching of 10% - 30%, reducing volatility and ensuring continuous and stable lubrication during equipment operation.

[0025] 2. The biodegradable antioxidant can effectively inhibit the oxidation of the lubricating oil, and can be rapidly degraded in the natural environment, reducing pollution, having no adverse effects on the human body and equipment, and ensuring the chemical stability of the lubricating oil during storage and use. The ratio of the polyether segment to the silicone segment of the polyether-modified silicone defoamer is (2 - 4):(1 - 3), which can be well compatible with other components while defoaming, avoiding phase separation, and ensuring stable operation of the lubricating oil under complex working conditions.

[0026] 3. The plant-based polyol ester has excellent biodegradability, meeting the strict environmental protection requirements of medical devices and reducing environmental pollution. The mineral base oil is treated by a double process of hydroisomerization dewaxing and adsorption refining, with a sulfur content of less than 10 ppm, a nitrogen content of less than 5 ppm, and an aromatic content of less than 1%, reducing the potential damage of impurities to medical devices and ensuring the safe operation of the equipment. At the same time, the entire lubricating oil formulation passes strict quality inspections, including biocompatibility tests, to ensure safety and harmlessness to patients and medical staff.

[0027] 4. Due to the perfluoroalkyl chain in the molecular structure of the fluorocarbon surfactant, it has excellent hydrophobic and oleophobic properties, significantly reducing the surface tension of the lubricating oil, enhancing the spreading and wetting properties on the surface of medical devices, improving the lubrication effect and protection performance, and synergistically acting with other components to enhance the comprehensive performance of the lubricating oil and meet the diverse usage requirements of medical devices. Specific embodiments

[0028] Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the scope of protection of the present invention.

[0029] Example 1

[0030] Dosage of raw materials: 5% of modified nano-silica dispersion, 30% of plant-based polyol ester, 0.5% of biodegradable antioxidant, 0.01% of fluorocarbon surfactant, 0.005% of polyether-modified silicone defoamer, and the balance is mineral base oil treated by a special removal process.

[0031] Raw material pretreatment: The surface of nano-silica was modified with γ-aminopropyltriethoxysilane and uniformly dispersed in propylene glycol methyl ether acetate to prepare a modified nano-silica dispersion. Then, ultrasonic dispersion treatment was carried out on this dispersion. The ultrasonic frequency was set at 30 kHz, the ultrasonic power was 200 W, and the ultrasonic time was 20 minutes. The plant-based polyol ester was prepared by the esterification reaction of natural vegetable oil and pentaerythritol under the catalysis of sulfuric acid, and then vacuum dehydration treatment was carried out on it. The vacuum degree was -0.09 MPa, the temperature was controlled at 80 °C, and the treatment time was 1 hour. The mineral base oil was successively subjected to hydroisomerization dewaxing and adsorption refining treatments to ensure that the sulfur content was less than 10 ppm, the nitrogen content was less than 5 ppm, and the aromatic hydrocarbon content was less than 1%.

[0032] Preliminary mixing: The treated mineral base oil was added to the reaction kettle, heated to 50 °C, and stirred at a stirring speed of 150 r / min for 15 minutes. After the temperature was uniform, the plant-based polyol ester and the biodegradable antioxidant (a compound of tocopherol and tea polyphenol in a weight ratio of 1:1) were successively added, and stirring was continued for 30 minutes to form a preliminary mixture.

[0033] Dispersion strengthening: The modified nano-silica dispersion was added to the preliminary mixture, the high-speed disperser was started, and dispersion was carried out at a rotation speed of 1000 r / min for 30 minutes. Then, high-pressure homogenization treatment was carried out, the homogenization pressure was 50 MPa, and the circulation treatment was carried out 2 times.

[0034] Additive addition: The temperature of the reaction kettle was controlled at 60 °C, a fluorocarbon surfactant and a polyether-modified silicone defoamer (the ratio of the polyether segment to the silicone segment was 2:1) were added, and stirring was carried out at a stirring speed of 200 r / min for 20 minutes.

[0035] Testing and packaging: Comprehensive quality tests such as biocompatibility, lubricating performance, and stability were carried out on the prepared lubricating oil. The biocompatibility test was carried out according to the ISO10993 standard; the lubricating performance was tested by a four-ball friction tester; the stability test included high-temperature stability and low-temperature stability tests. After passing the tests, packaging was carried out in an environment of Class 10,000 dust-free, fully enclosed and double-sterilized by ultraviolet light and ozone.

[0036] Example 2

[0037] Raw material dosage: 10% of the modified nano-silica dispersion, 40% of the plant-based polyol ester, 1.5% of the biodegradable antioxidant, 0.05% of the fluorocarbon surfactant, 0.01% of the polyether-modified silicone defoamer, and the balance was the mineral base oil treated by a special removal process.

[0038] Raw material pretreatment: The surface of nano-silica was modified with γ-methacryloxypropyltrimethoxysilane, dispersed in diethylene glycol butyl ether to prepare a dispersion, and then ultrasonic dispersion was carried out. The ultrasonic frequency was 40 kHz, the ultrasonic power was 350 W, and the ultrasonic time was 30 minutes. The plant-based polyol ester was prepared by the esterification reaction of castor oil and glycerol. The vacuum dehydration treatment conditions were a vacuum degree of -0.095 MPa, a temperature of 70 °C, and a treatment time of 1.5 hours. The mineral base oil was also subjected to hydroisomerization dewaxing and adsorption refining treatment.

[0039] Initial mixing: The treated mineral base oil was added to the reaction kettle, heated to 60 °C, stirred at a stirring speed of 250 r / min for 20 minutes, and then the plant-based polyol ester and the biodegradable antioxidant (the weight ratio of tocopherol to tea polyphenol was 2:1) were added in sequence and stirred for 45 minutes.

[0040] Dispersion strengthening: The modified nano-silica dispersion was added. The rotation speed of the high-speed disperser was set at 2000 r / min and dispersed for 45 minutes. The homogenization pressure of the high-pressure homogenizer was 75 MPa, and the circulation treatment was carried out 3 times.

[0041] Addition of additives: The temperature of the reaction kettle was controlled at 70 °C, and a fluorocarbon surfactant and a polyether-modified silicone defoamer (the ratio of the polyether segment to the silicone segment was 3:2) were added, and the stirring speed was 300 r / min and stirred for 30 minutes.

[0042] Testing and packaging: The same testing and packaging process as in Example 1 was carried out, and the lubricating oil was packaged after ensuring that the quality met the standards.

[0043] Example 3

[0044] Dosage of raw materials: 15% of the modified nano-silica dispersion, 50% of the plant-based polyol ester, 3% of the biodegradable antioxidant, 0.1% of the fluorocarbon surfactant, 0.02% of the polyether-modified silicone defoamer, and the balance was the mineral base oil treated by a special removal process.

[0045] Raw material pretreatment: The surface of nano-silica was modified with γ-mercaptopropyltrimethoxysilane, dispersed in propylene glycol methyl ether. When ultrasonic dispersion was carried out, the ultrasonic frequency was 50 kHz, the ultrasonic power was 500 W, and the ultrasonic time was 40 minutes. The plant-based polyol ester was obtained by the esterification reaction of soybean oil and xylitol. When vacuum dehydration treatment was carried out, the vacuum degree was -0.1 MPa, the temperature was 60 °C, and the treatment time was 2 hours. The mineral base oil was treated to meet the standards.

[0046] Initial mixing: The treated mineral base oil was added to the reaction kettle, heated to 70 °C, stirred at a stirring speed of 350 r / min for 30 minutes, and then the plant-based polyol ester and the biodegradable antioxidant (the weight ratio of tocopherol to tea polyphenol was 3:2) were added and stirred for 60 minutes.

[0047] Dispersion strengthening: Add the modified nano-silica dispersion liquid, the rotation speed of the high-speed disperser is 3000 r / min, disperse for 60 minutes, the homogenization pressure of the high-pressure homogenizer is 100 MPa, and circulate and process 4 times.

[0048] Addition of additives: Control the temperature of the reaction kettle at 80 °C, add fluorocarbon surfactant and polyether-modified silicone defoamer (the ratio of polyether segment to silicone segment is 4:3), the stirring speed is 400 r / min, and stir for 40 minutes.

[0049] Inspection and packaging: According to the established inspection and packaging process, package after passing the inspection.

[0050] The above are only the preferred embodiments of the present invention and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A lubricating oil for medical equipment, characterized in that: The invention comprises the following components in percentage by weight: 5%-15% of modified nano silicon dioxide dispersion, 30%-50% of plant-based polyol ester, 0.5%-3% of biodegradable antioxidant, 0.01%-0.1% of fluorocarbon surfactant, 0.005%-0.02% of polyether modified organic silicon defoamer, and the rest is mineral base oil treated by a special removal process. The modified nano silicon dioxide dispersion is prepared by surface modification of nano silicon dioxide by a silane coupling agent and uniformly dispersing the nano silicon dioxide in a specific organic solvent. The average particle size is between 5 and 20 nanometers, and the dispersion is used to enhance the wear resistance and load-bearing capacity of lubricating oil and improve the thermal stability of lubricating oil.

2. The lubricating oil for medical equipment according to claim 1, characterized in that: The plant-based polyol ester is prepared by esterification reaction of natural plant oil and polyol, and its unsaturated bond content is less than 5%, and the branching degree is between 10% and 30%.

3. The lubricating oil for medical equipment according to claim 1, characterized in that: The biodegradable antioxidant is a compound of tocopherol and tea polyphenols, and the weight ratio of the two is (1-3):(1-2).

4. The lubricating oil for medical equipment according to claim 1, characterized in that: The fluorocarbon surfactant contains a perfluoroalkyl chain in its molecular structure.

5. The lubricating oil for medical equipment according to claim 1, characterized in that: The ratio of the polyether segment to the silicone segment of the polyether-modified silicone defoamer is (2-4):(1-3).

6. The lubricating oil for medical equipment according to claim 1, characterized in that: The mineral base oil is treated by a dual process of hydroisomerization dewaxing and adsorption refining, and has a sulfur content of less than 10 ppm, a nitrogen content of less than 5 ppm, and an aromatics content of less than 1%.

7. A method for preparing the lubricating oil for medical equipment according to any one of claims 1 to 6, characterized in that: The following steps are involved: Raw material pretreatment: Surface modification of nano-silicon dioxide to prepare modified nano-silicon dioxide dispersion; vacuum dehydration of plant-based polyol ester to remove water and low-boiling impurities; hydroisomerization dewaxing and adsorption refining of mineral base oil; Preliminary mixing: Add the treated mineral base oil into the reactor, heat it to 50-70°C, and stir it at a stirring speed of 150-350r / min for 15-30 minutes to make the temperature uniform; add plant-based polyol ester and biodegradable antioxidant in sequence, and continue stirring for 30-60 minutes to form a preliminary mixed solution; Dispersion enhancement: Add modified nano-silicon dioxide dispersion to the preliminary mixed solution, start the high-speed disperser, and disperse at a speed of 1000-3000r / min for 30-60 minutes to evenly disperse the nanoparticles in the mixed solution; Adding additives: Control the temperature of the reactor at 60-80°C, add fluorocarbon surfactant and polyether modified silicone defoamer, and stir at a stirring speed of 200-400r / min for 20-40 minutes; Testing and packaging: The prepared lubricants are subjected to comprehensive quality testing, including testing of biocompatibility, lubrication performance, stability and other indicators; after passing the test, they are packaged in a 10,000-level dust-free, fully enclosed environment that is dual-sterilized with ultraviolet light and ozone.

8. The preparation method according to claim 7, characterized in that: In the raw material pretreatment stage, the modified nano-silicon dioxide dispersion is subjected to ultrasonic dispersion treatment, with an ultrasonic frequency of 30-50 kHz, an ultrasonic power of 200-500 W, and an ultrasonic time of 20-40 minutes.

9. The preparation method according to claim 7, characterized in that: In the dispersion strengthening stage, a high-pressure homogenizer is used to treat the mixed liquid, the homogenization pressure is 50-100 MPa, and the treatment is circulated 2-4 times.