Sampling device for pharmaceutical experiment

Abstract

The invention relates to the technical field of sampling, in particular to a sampling device for pharmaceutical experiments, which comprises a bottom plate, a box body, a rotating shaft, a rotating plate, a sampling bottle, a sampling tube and the like, the top of the bottom plate is connected with the box body, the box body is provided with an outlet, the top of the bottom plate is rotatably connected with the rotating shaft, the rotating shaft is located in the box body, and the rotating shaft is connected with the rotating plate. Five sampling bottles are uniformly and slidably connected to the rotating plate at intervals in the circumferential direction, and the bottoms of the sampling bottles are communicated with sampling pipes. A pushing block can be driven to move rightwards through an electric guide rail, so that the pushing block does not push a sliding rod any more, a piston block moves upwards under the action of a first spring, medicine enters a sampling bottle through a sampling tube, the operation is repeated, the medicine can be sampled automatically and continuously, the efficiency is higher, manual intervention can be reduced, and the labor intensity of workers is reduced. And cross contamination is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of sampling, and in particular to a sample extraction device for pharmaceutical experiments. Background Art

[0002] In many fields such as medical education, biological experiments, and drug research and development, pharmaceutical experiments are an indispensable part. In order to comprehensively understand the characteristics of drugs and their effects on organisms, researchers need to conduct a series of precise and systematic experiments. These experiments not only require a high level of professional knowledge and technology but also rely on sophisticated experimental equipment and tools. Among them, the sampler, as a common experimental tool, plays a crucial role in pharmaceutical research.

[0003] Samplers are mainly used to extract quantitative liquid or solid samples from pharmaceutical preparations or other sample sources for subsequent analysis. Most current samplers are of the piston extraction design, which is easy to operate but relatively single in function.

[0004] With the in-depth development of scientific research and technological progress, in the actual operation process, researchers often need to take samples of multiple drugs multiple times or collect multiple different samples in the same experiment. Most current samplers still adopt the manual operation mode. After each use, researchers must manually pull out the piston and place the sampler, and then take out another sampler for the next sampling. The operation process is relatively cumbersome, with low efficiency, and frequent manual operations increase the risk of cross-contamination. Especially when dealing with highly sensitive or toxic samples, this poses a potential threat to experimental safety. Summary of the Invention

[0005] In view of this, the present invention provides a sample extraction device for pharmaceutical experiments, which can overcome the disadvantages that it is necessary to manually pull out the piston and place the sampler, then take out another sampler for the next sampling, the operation process is relatively cumbersome, the efficiency is low, and frequent manual operations increase the risk of cross-contamination. Especially when dealing with highly sensitive or toxic samples, this poses a potential threat to experimental safety.

[0006] The technical solution of the present invention is as follows: A sampling device for pharmaceutical experiments includes a bottom plate, a box body, a rotating shaft, a rotating plate, sampling bottles, sampling tubes, mounting rods, support rings, piston blocks, sliding rods, first springs, a pressing mechanism and a switching mechanism. The top of the bottom plate is connected to the box body. There is an extraction port on the box body. The top of the bottom plate is rotatably connected to a rotating shaft. The rotating shaft is located inside the box body. A rotating plate is connected to the rotating shaft. Five sampling bottles are circumferentially and evenly spaced and slidably connected to the rotating plate. The bottoms of the sampling bottles are all communicated with sampling tubes. The top of the rotating plate is connected to a mounting rod. A support ring is connected to the mounting rod. The upper parts of the sampling bottles are in contact with the top of the support ring to support the sampling bottles. Piston blocks are slidably and sealingly connected inside the sampling bottles. Sliding rods are connected to the tops of the piston blocks. The sliding rods slidably penetrate through the tops of the sampling bottles. First springs are connected between the sliding rods and the sampling bottles. A circular hole is opened on the bottom plate. The pressing mechanism is used to push the sampling bottles downward so that the sampling bottles extend out from the circular hole. The switching mechanism is used to switch the sampling bottles.

[0007] As a preferred technical solution of the present invention, the pressing mechanism includes an electric guide rail, a pushing frame, a pushing block, a guide rod, a lifting block, a second spring and a contact rod. The electric guide rail is installed inside the box body. The bottom of the slider of the electric guide rail is connected to the pushing frame. The top inside the pushing frame is connected to the pushing block. A guide rod is connected to the top of the rotating plate. A lifting block is slidably connected to the guide rod in common. The lifting block slidably penetrates through the support ring. All five sampling bottles can rotate into the lifting block. A second spring is connected between the rotating plate and the lifting block. A contact rod is connected to the top of the lifting block. During the process of the pushing frame moving to the left, it will contact the contact rod and push the contact rod downward. The contact rod drives the lifting block to move downward, and the lifting block drives the sampling bottles to move downward so that the sampling bottles extend out from the circular hole.

[0008] As a preferred technical solution of the present invention, the switching mechanism includes a gear, a guide sleeve, a rack, a contact plate and a third spring. The gear is connected to the rotating shaft through a one-way clutch. The top of the bottom plate is connected to a guide sleeve. The guide sleeve is located inside the box body. A rack is slidably connected inside the guide sleeve. The rack will engage with the gear during the process of moving to the left. A contact plate is connected to the rack. A third spring is connected between the guide sleeve and the contact plate.

[0009] As a preferred technical solution of the present invention, it further includes positioning beads and a fourth spring. Five positioning grooves are circumferentially and evenly spaced on the bottom of the gear. Five positioning beads are slidably and evenly spaced on the top of the bottom plate. The positioning beads are located in the positioning grooves to position the gear. The rotating shaft is located between the five positioning beads. A fourth spring is connected between the positioning beads and the bottom plate.

[0010] As a preferred technical solution of the present invention, it further includes rollers. The upper end of the contact rod is rotatably connected to the rollers.

[0011] As a preferred technical solution of the present invention, it further includes a protective door. A protective door for sealing the extraction port is hinged on the box body.

[0012] As a preferred technical solution of the present invention, it further includes a transparent plate, and a transparent plate for observing the sampling bottle is connected to the box body.

[0013] As a preferred technical solution of the present invention, scale lines are provided on the sampling bottles.

[0014] The beneficial effects are as follows: 1. In the present invention, the electric guide rail can drive the pushing block to move to the right, so that the pushing block no longer pushes the sliding rod. Under the action of the first spring, the piston block will move upward, and the drug enters the sampling bottle through the sampling tube. By repeating this operation, the drug can be sampled automatically and continuously, with higher efficiency, and manual intervention can be reduced to avoid cross-contamination.

[0015] 2. The positioning bead can be inserted into the positioning groove to position the gear, thereby positioning the sampling bottle, and preventing the position of the sampling bottle from shifting, resulting in the sampling bottle being unable to extend out of the round hole. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 Shows a three-dimensional structural schematic diagram of the present invention.

[0017] Figure 2 Shows a three-dimensional structural schematic diagram of the rotating shaft, rotating plate, sampling bottle, sampling tube, sliding rod, first spring and round hole of the present invention.

[0018] Figure 3 Shows a three-dimensional structural schematic diagram of the sampling bottle, mounting rod and support ring of the present invention.

[0019] Figure 4 Shows a cross-sectional view of the sampling bottle of the present invention.

[0020] Figure 5 Shows a first three-dimensional structural schematic diagram of the pressing mechanism of the present invention.

[0021] Figure 6 Shows a cross-sectional view of the pushing frame of the present invention.

[0022] Figure 7 Shows a second three-dimensional structural schematic diagram of the pressing mechanism of the present invention.

[0023] Figure 8 Shows a three-dimensional structural schematic diagram of the switching mechanism of the present invention.

[0024] Figure 9 Shows a three-dimensional structural schematic diagram of the positioning bead of the present invention.

[0025] Figure 10 Shows a three-dimensional structural schematic diagram of the positioning groove of the present invention.

[0026] Figure 11The cross-sectional view of the bottom plate of the present invention is shown.

[0027] Wherein: 1-bottom plate, 2-box body, 3-outlet, 4-rotating shaft, 5-rotating plate, 6-sampling bottle, 61-sampling tube, 7-mounting rod, 8-supporting ring, 9-piston block, 10-sliding rod, 11-first spring, 12-round hole, 131-electric guide rail, 132-pushing frame, 133-pushing block, 134-guide rod, 135-lifting block, 136-second spring, 137-contact rod, 141-gear, 142-guide sleeve, 143-rack, 144-contact plate, 145-third spring, 151-positioning groove, 152-positioning bead, 153-fourth spring, 16-roller, 17-protective door, 18-transparent plate. Detailed implementation manners

[0028] The technical solution of the present invention will be further described below with reference to the accompanying drawings.

[0029] Referring to Figures 1 - 8 ,, a sampling device for pharmaceutical experiments, comprising a bottom plate 1, a box body 2, a rotating shaft 4, a rotating plate 5, a sampling bottle 6, a sampling tube 61, a mounting rod 7, a supporting ring 8, a piston block 9, a sliding rod 10, a first spring 11, a pressing mechanism and a switching mechanism. The top of the bottom plate 1 is connected to the box body 2 by bolts. There is a handle on the top of the box body 2, and the box body 2 can be carried by the handle. An outlet 3 is opened on the front side of the box body 2. The middle of the top of the bottom plate 1 is rotatably connected to a rotating shaft 4. The rotating shaft 4 is located inside the box body 2. The upper end of the rotating shaft 4 is connected to a rotating plate 5. Five sampling bottles 6 are circumferentially and evenly spaced and slidably connected to the rotating plate 5. The middle of the bottom of each sampling bottle 6 is communicated with a sampling tube 61. Four mounting rods 7 are evenly spaced and connected to the top of the rotating plate 5. The upper ends of the four mounting rods 7 are jointly connected to a supporting ring 8. The upper part of the sampling bottle 6 contacts the top of the supporting ring 8. The hand can be inserted into the box body 2 through the outlet 3, and the sampling bottle 6 can be pulled upward to take out the sampling bottle 6 from the box body 2. A piston block 9 is slidably and sealingly connected to each sampling bottle 6. A scale line is provided on each sampling bottle 6. When extracting the drug, the moving distance of the piston block 9 can be seen through the scale line, so as to accurately control the extraction amount of the drug. The top of each piston block 9 is connected to a sliding rod 10. The sliding rod 10 slidably penetrates the top of the sampling bottle 6. A first spring 11 is sleeved on each sliding rod 10. The two ends of the first spring 11 are respectively connected to the sliding rod 10 and the sampling bottle 6. The first spring 11 is sleeved on the sliding rod 10 to prevent the first spring 11 from bending. A round hole 12 is opened on the left part of the bottom plate 1. The pressing mechanism is used to push the sampling bottle 6 downward so that the sampling bottle 6 extends out of the round hole 12. The switching mechanism is used to switch the sampling bottle 6.

[0030] Referring to Figures 5 - 7, the pressing mechanism includes an electric guide rail 131, a pushing frame 132, a pushing block 133, a guide rod 134, a lifting block 135, a second spring 136 and a contact rod 137. The electric guide rail 131 is installed at the top inside the box body 2 by bolts. The bottom of the slider of the electric guide rail 131 is connected to the pushing frame 132. The left side of the pushing frame 132 is an inclined surface, and the bottom of the pushing frame 132 is a horizontal surface. The top inside of the pushing frame 132 is connected to the pushing block 133. The left side of the pushing block 133 is an inclined surface. The left side of the top of the rotating plate 5 is connected with two guide rods 134. A lifting block 135 is slidably connected to the two guide rods 134 together. The lifting block 135 slidably penetrates through the left side of the support ring 8. All five sampling bottles 6 can rotate into the lifting block 135. Second springs 136 are sleeved on the guide rods 134. The two ends of the second spring 136 are respectively connected to the rotating plate 5 and the lifting block 135. The second spring 136 is sleeved on the guide rod 134, which can prevent the second spring 136 from bending. Contact rods 137 are connected to the front and rear sides of the top of the lifting block 135. The pushing frame 132 will contact the contact rod 137 during the process of moving leftward.

[0031] Refer to Figure 8 , the switching mechanism includes a gear 141, a guide sleeve 142, a rack 143, a contact plate 144 and a third spring 145. The lower part of the rotating shaft 4 is connected to the gear 141 through a one-way clutch. The right side of the top of the bottom plate 1 is connected to the guide sleeve 142 by bolts. The guide sleeve 142 is located inside the box body 2. A rack 143 is slidably connected inside the guide sleeve 142. The rack 143 will mesh with the gear 141 during the process of moving leftward. The right end of the rack 143 is connected to the contact plate 144. The right side of the pushing frame 132 contacts the left side of the contact plate 144. A third spring 145 is connected between the right side of the guide sleeve 142 and the left side of the contact plate 144.

[0032] Initially, the pushing frame 132 pushes the contact plate 144, and the third spring 145 is in a stretched state; the staff picks up the box body 2, aligns the round hole 12 with the mouth of the medicine bottle, and then controls the electric guide rail 131 to drive the pushing frame 132 and the pushing block 133 to move leftward. The pushing frame 132 no longer pushes the contact plate 144. Under the action of the third spring 145, the contact plate 144 and the rack 143 move leftward. During the leftward movement of the rack 143, it will engage with the gear 141, and the rack 143 drives the gear 141 to rotate. Under the action of the one-way clutch, the gear 141 will not drive the rotating shaft 4 to rotate. After the pushing frame 132 and the contact plate 144 are disengaged, the third spring 145 returns to its original state, the rack 143 stops moving, and the gear 141 stops rotating. Subsequently, the inclined surface of the pushing frame 132 will contact the contact rod 137 and push the contact rod 137 downward. The contact rod 137 drives the lifting block 135 to move downward, the second spring 136 is compressed, the lifting block 135 drives the sampling bottle 6 and the sampling tube 61 to move downward, the sampling bottle 6 will extend out of the round hole 12, and the sampling tube 61 will extend into the medicine bottle and contact the medicine. At this time, the horizontal surface of the pushing frame 132 will contact the contact rod 137, and the pushing frame 132 will no longer push the contact rod 137. Subsequently, the inclined surface of the pushing block 133 will contact the sliding rod 10 and push the sliding rod 10 downward, the first spring 11 is compressed, the sliding rod 10 drives the piston block 9 to move downward, and the air in the sampling bottle 6 is discharged through the sampling tube 61. The moving distance of the piston block 9 is the extraction amount of the medicine, and the extraction amount of the medicine can be controlled. When the piston block 9 moves to an appropriate distance, control the electric guide rail 131 to drive the pushing frame 132 and the pushing block 133 to move rightward. The pushing block 133 no longer pushes the sliding rod 10. Under the action of the first spring 11, the sliding rod 10 and the piston block 9 move upward, and the medicine enters the sampling bottle 6 through the sampling tube 61 to extract the medicine. At this time, the horizontal surface of the pushing frame 132 still contacts the contact rod 137, the contact rod 137 will not move, and the sampling bottle 6 and the sampling tube 61 will not move either, ensuring that the sampling tube 61 can continuously extract the medicine. After the inclined surface of the pushing block 133 and the sliding rod 10 are disengaged, the sliding rod 10 and the piston block 9 stop moving upward. Subsequently, the horizontal surface of the pushing frame 132 and the contact rod 137 are disengaged, the inclined surface of the pushing frame 132 contacts the contact rod 137 again, the pushing frame 132 no longer pushes the contact rod 137, and the lifting block 135 and the contact rod 137 move upward under the action of the second spring 136, and the sampling bottle 6 and the sampling tube 61 move upward and reset accordingly. At this time, the pushing frame 132 continues to move rightward, the pushing frame 132 will contact the contact plate 144 and push the contact plate 144 to move rightward, the third spring 145 is stretched, the contact plate 144 drives the rack 143 to move rightward, the rack 143 drives the gear 141 to rotate in the reverse direction, the gear 141 drives the rotating shaft 4 to rotate, the rotating shaft 4 drives the rotating plate 5 to rotate, and the rotating plate 5 drives the sampling bottle 6 to rotate, moving the sampling bottle 6 containing the medicine out of the lifting block 135.The next empty sampling bottle 6 is rotated into the lifting block 135. After the rack 143 and the gear 141 are disengaged, the gear 141 stops rotating. The gear 141 rotates exactly 72 degrees (one fifth of a circle), and the sampling bottle 6 also rotates exactly 72 degrees (one fifth of a circle). Repeat the above operation to continue sampling the medicine. The medicine can be sampled automatically and continuously, which is more efficient, reduces manual intervention, and avoids cross contamination.

[0033] Reference Figures 9 - 11 , also includes a positioning bead 152 and a fourth spring 153. Five positioning grooves 151 are evenly spaced apart at the bottom of the gear 141 in the circumferential direction. Five positioning beads 152 are evenly spaced apart and slidably connected to the top of the bottom plate 1. The positioning bead 152 is located in the positioning groove 151 to position the gear 141. The rotating shaft 4 is located between the five positioning beads 152. A fourth spring 153 is connected between the positioning bead 152 and the bottom plate 1. The fourth spring 153 is located in the bottom plate 1.

[0034] When the gear 141 rotates, it pushes the positioning bead 152 to move downward, the fourth spring 153 is compressed, and the positioning bead 152 is moved out of the positioning groove 151. The positioning bead 152 and the positioning groove 151 are staggered, and when the next sampling bottle 6 rotates to the lifting block 135, the positioning bead 152 corresponds to the positioning groove 151 again. Under the action of the fourth spring 153, the positioning bead 152 moves upward and is inserted into the positioning groove 151 to position the gear 141, thereby positioning the sampling bottle 6 to prevent the position of the sampling bottle 6 from being offset and causing the sampling bottle 6 to be unable to extend from the round hole 12.

[0035] Reference Figure 7 , also includes a roller 16, and the upper end of the contact rod 137 is rotatably connected to the roller 16. When the push frame 132 moves to the left, the inclined surface on the push frame 132 will contact the roller 16 to avoid friction between the push frame 132 and the contact rod 137, thereby avoiding wear of the push frame 132 and the contact rod 137.

[0036] Reference Figure 1 , and also includes a protective door 17. The front side of the box body 2 is hinged with the protective door 17. The protective door 17 can seal the removal port 3 to prevent dust from floating into the box body 2 through the removal port 3. The protective door 17 is made of transparent material, and the sampling bottle 6 can be seen through the protective door 17, so that the staff can judge whether there is medicine in the sampling bottle 6.

[0037] Reference Figure 1 , and also includes a transparent plate 18. The lower left part of the box body 2 is connected with the transparent plate 18. The sampling bottle 6 and the piston block 9 can be seen through the transparent plate 18 to control the extraction amount of the drug.

[0038] The above are only examples of the present invention and are not intended to limit the present invention. Any equivalent replacement made within the principles of the present invention shall be included within the protection scope of the present invention. The content not elaborated in detail in the present invention belongs to the prior art well-known to those skilled in the relevant technical field.

Claims

1. A sample extraction device for pharmaceutical experiments, comprising a base plate (1) and a box body (2), wherein the top of the base plate (1) is connected to the box body (2), and the box body (2) is provided with a take-out port (3), characterized in that: The utility model also comprises a rotating shaft (4), a rotating plate (5), a sampling bottle (6), a sampling tube (61), a mounting rod (7), a supporting ring (8), a piston block (9), a sliding rod (10), a first spring (11), a pressing mechanism and a switching mechanism. The top of the bottom plate (1) is rotatably connected with the rotating shaft (4), the rotating shaft (4) is located in the box body (2), the rotating shaft (4) is connected with the rotating plate (5), five sampling bottles (6) are slidably connected to the rotating plate (5) at even intervals in the circumferential direction, the bottoms of the sampling bottles (6) are all connected with the sampling tube (61), the top of the rotating plate (5) is connected with the mounting rod (7), and the mounting rod (7) is connected with the first spring (11). A support ring (8) is connected, the upper part of the sampling bottle (6) contacts the top of the support ring (8) to support the sampling bottle (6), a piston block (9) is slidably and sealedly connected inside the sampling bottle (6), the top of the piston block (9) is connected to a slide rod (10), the slide rod (10) slides through the top of the sampling bottle (6), a first spring (11) is connected between the slide rod (10) and the sampling bottle (6), a round hole (12) is opened on the bottom plate (1), the pressing mechanism is used to push the sampling bottle (6) to move downward so that the sampling bottle (6) extends from the round hole (12), and the switching mechanism is used to switch the sampling bottle (6).

2. A sampling device for pharmaceutical experiments as claimed in claim 1, characterized in that: The pressing mechanism comprises an electric guide rail (131), a pushing frame (132), a pushing block (133), a guide rod (134), a lifting block (135), a second spring (136) and a contact rod (137). The box body (2) is provided with the electric guide rail (131). The bottom of the slider of the electric guide rail (131) is connected to the pushing frame (132). The top of the pushing frame (132) is connected to the pushing block (133). The top of the rotating plate (5) is connected to the guide rod (134). The guide rod (134) is slidably connected to the lifting block (135). The lifting block (135) slides The five sampling bottles (6) are all able to rotate into the lifting block (135) by passing through the support ring (8). A second spring (136) is connected between the rotating plate (5) and the lifting block (135). A contact rod (137) is connected to the top of the lifting block (135). The pushing frame (132) contacts the contact rod (137) during the process of moving to the left, and pushes the contact rod (137) to move downward. The contact rod (137) drives the lifting block (135) to move downward, and the lifting block (135) drives the sampling bottle (6) to move downward, so that the sampling bottle (6) extends out of the round hole (12).

3. A sampling device for pharmaceutical experiments as claimed in claim 2, characterized in that: The switching mechanism comprises a gear (141), a guide sleeve (142), a rack (143), a contact plate (144) and a third spring (145); the rotating shaft (4) is connected with the gear (141) via a one-way clutch; the top of the bottom plate (1) is connected with the guide sleeve (142); the guide sleeve (142) is located in the housing (2); the guide sleeve (142) is slidably connected with the rack (143); the rack (143) meshes with the gear (141) during the process of moving to the left; the rack (143) is connected with the contact plate (144); and the third spring (145) is connected between the guide sleeve (142) and the contact plate (144).

4. A sampling device for pharmaceutical experiments as claimed in claim 3, characterized in that: The invention also includes a positioning bead (152) and a fourth spring (153). Five positioning grooves (151) are evenly spaced apart at the bottom of the gear (141) in the circumferential direction. Five positioning beads (152) are evenly spaced apart at the top of the bottom plate (1) and are slidably connected. The positioning bead (152) is located in the positioning groove (151) to position the gear (141). The rotating shaft (4) is located between the five positioning beads (152). A fourth spring (153) is connected between the positioning bead (152) and the bottom plate (1).

5. A sampling device for pharmaceutical experiments as claimed in claim 4, characterized in that: It also includes a roller (16), and the upper end of the contact rod (137) is rotatably connected to the roller (16).

6. A sampling device for pharmaceutical experiments as claimed in claim 5, characterized in that: It also comprises a protective door (17), which is hinged on the box body (2) and is used to seal the removal port (3).

7. A sampling device for pharmaceutical experiments as claimed in claim 6, characterized in that: It also includes a transparent plate (18), and the box body (2) is connected with the transparent plate (18) for observing the sampling bottle (6).

8. A sampling device for pharmaceutical experiments as claimed in claim 7, characterized in that: The sampling bottles (6) are all provided with scale lines.

Images