Oral cavity antibacterial paste capable of deeply resisting bacteria and preparation method of oral cavity antibacterial paste

Abstract

The invention relates to the field of oral cleaning products, in particular to oral antibacterial paste capable of deeply resisting bacteria and a preparation method of the oral antibacterial paste. According to the technical scheme, the incision smearing healing medicine capable of achieving rapid treatment is prepared from 15-25 parts of hydrated silica, 53-67 parts of sorbitol, 5.1-9.1 parts of water, 1.5-2.5 parts of cocamidopropyl betaine and 4-6 parts of glycerin, pathogenic bacteria are rapidly killed through triclosan, the micro-ecology is continuously adjusted through probiotics and plant extracts, the risk of drug resistance is reduced, and the healing effect is good. The plant anti-inflammatory components in the traditional Chinese medicine mixed extract are combined with the glycerol, so that red and swollen gums are relieved, wound healing is accelerated, then cocamidopropyl betaine is used for mildly cleaning oral mucosa, assisting in removing food residues and reducing bacterial attachment, and the anti-inflammatory effect is achieved. The toothpaste can deeply clean dead corners such as gingival gaps and deep mucous membranes, and can deeply play a role in the interior by virtue of an anti-bacteria and decomposition technology, so that the problem that a common oral product is limited in cleaning effect and only can clean the surface is solved.

Description

Technical Field

[0001] The present invention relates to the field of oral care products, and particularly to an oral antibacterial paste with deep antibacterial properties and a preparation method thereof. Background Art

[0002] With the improvement of economic and cultural levels, people have paid increasing attention to oral health and hygiene. Through people's promotion, oral antibacterial products are developing at a growth rate of about 40% per year and will occupy a certain market share in the future, especially in oral diagnosis and treatment places. It makes up for the segmented needs beyond oral cleaning and has a huge volume, among which oral antibacterial paste plays a huge role.

[0003] However, during the use of existing oral antibacterial pastes, they often rely only on brushing teeth. But regular brushing can only clean about 70% of the parts, and it is often impossible to clean about 30% of the hygiene dead corners. As a result, the oral problems of users gradually get out of control over the years, thus affecting the oral health of users. Summary of the Invention

[0004] In order to overcome the drawback that existing oral antibacterial pastes can only clean 70% of the oral cavity of users based on the brushing area during use, which leads to a large number of oral problems still existing in the oral cavity of users after a long time of accumulation, thus affecting the oral health of users.

[0005] The technical solution of the present invention is: an oral antibacterial paste with deep antibacterial properties, comprising the following components: 15 - 25 parts of hydrated silica, 53 - 67 parts of sorbitol, 5.1 - 9.1 parts of water, 1.5 - 2.5 parts of cocamidopropyl betaine, 4 - 6 parts of glycerol, 0.5 - 0.9 parts of xanthan gum, 0.8 - 1.2 parts of Pediococcus pentosaceus JYPR9330, 2.5 - 3.5 parts of a traditional Chinese medicine mixed extract, 0.1 part of a preservative, 1 part of a sugar alcohol mixture, and 0.1 part of triclosan.

[0006] Preferably, the traditional Chinese medicine mixed extract is composed of jasmine, chrysanthemum, dandelion, licorice, tangerine peel, rehmannia root, houttuynia cordata, perilla, achyranthes bidentata, and mint;

[0007] The preservative is composed of 0.07 part of caprylyl glycol and 0.03 part of sorbitol;

[0008] The sugar alcohol mixture is composed of 0.5 part of xylitol and 0.5 part of erythritol.

[0009] A preparation method of an oral antibacterial paste with deep antibacterial properties, which includes the oral antibacterial paste with deep antibacterial properties as described above, and the steps are as follows:

[0010] Step 1: Material Preparation

[0011] Weigh the dosage of each medicinal material precisely according to the required formula, ensuring that all medicinal materials are dry, free of impurities, and of excellent quality.

[0012] Step 2: Pretreatment of Medicinal Materials

[0013] Clean the medicinal materials according to their characteristics to remove the dust and impurities on the surface. For better efficacy, pre-mix the medicinal materials and then concentrate them.

[0014] Step 3: Aqueous Phase Mixing

[0015] Add water, sorbitol, and glycerol into the reaction kettle, heat to 45 ± 5 °C, and stir until dissolved; slowly add xanthan gum and homogenize until completely dispersed without particles.

[0016] Add the sugar alcohol mixture and stir until dissolved.

[0017] Step 4: Oil Phase Mixing

[0018] Mix cocamidopropyl betaine and triclosan, and add preservatives, stir at room temperature until homogeneous.

[0019] Step 5: Mixing and Homogenization

[0020] Slowly add the oil phase into the aqueous phase, keep the temperature at 45 °C constant, and mix with a homogenizer.

[0021] Add hydrated silica and grind with a ball mill to ensure the paste is delicate.

[0022] Add plant extracts and stir at low speed to avoid bubbles.

[0023] Step 6: Addition of Active Ingredients

[0024] Cool down to below 30 °C, add Pediococcus pentosaceus JYPR9330, and stir at low speed.

[0025] Step 7: Post-treatment.

[0026] Perform vacuum degassing to eliminate bubbles.

[0027] Add citric acid to adjust the pH to 6.5 - 7.5.

[0028] Fill into a pollution-proof pump container and store in the dark.

[0029] Preferably, according to Step 2, mix jasmine, chrysanthemum, dandelion, licorice, tangerine peel, rehmannia root, houttuynia cordata, perilla, achyranthes bidentata, and mint in a ratio of 2%, 15%, 10%, 12%, 7%, 6%, 10%, 8%, 5%, and 25%, and concentrate to dry extract by water extraction process.

[0030] Preferably, according to step three, the speed of the homogenizer is set to 2000 rpm and the homogenization time is set to 10-12 minutes.

[0031] Preferably, according to step five, the speed of the homogenizer is set to 3000 rpm, the homogenization time is set to 15-18 minutes, and the grinding particle size of the ball mill is ≤20 μm.

[0032] Preferably, according to step six, a homogenizer is used for stirring, the high shear function is turned off, only basic stirring is retained, the rotation speed is less than 100 rpm, and the stirring time is set to 5-7 minutes.

[0033] Preferably, the pressure of the vacuum degassing in step seven is set to -0.08 MPa, and the time is set to 10-15 minutes.

[0034] The beneficial effects of the present invention include: rapid killing of pathogenic bacteria by triclosan, continuous regulation of microecology by probiotics and plant extracts, and reduction of the risk of drug resistance, so as to achieve short-term and long-term antibacterial effects; and the combination of plant anti-inflammatory components in the mixed extract of traditional Chinese medicine with glycerin, thereby alleviating gingival redness and swelling and accelerating wound healing; and gentle cleaning of the oral mucosa by cocamidopropyl betaine, assisting in the removal of food residues, and reducing bacterial attachment, so as to penetrate deep into the gingival gaps, deep into the mucosa and other cleaning dead corners; and anti-bacterial and decomposition technology, which penetrate into the inside to exert their effects, thereby breaking away from the cleaning effect limitation of ordinary oral products, which can only clean the surface. DETAILED DESCRIPTION

[0035] Example 1

[0036] The present invention will be further described below in conjunction with the embodiments.

[0037] The present invention provides an embodiment: an oral antibacterial cream capable of deep antibacterial, comprising the following components: 15 parts of hydrated silica, 67 parts of sorbitol, 5.1 parts of water, 1.5 parts of cocamidopropyl betaine, 6 parts of glycerol, 0.5 parts of xanthan gum, 1.2 parts of Pediococcus pentosaceus JYPR9330, 2.5 parts of mixed extracts of traditional Chinese medicines, 0.1 parts of preservatives, 1 part of a sugar alcohol mixture, and 0.1 parts of triclosan;

[0038] The Chinese medicine mixed extract is composed of jasmine, chrysanthemum, dandelion, liquorice, tangerine peel, radix rehmanniae, houttuynia, perilla, rhizoma achyranthis Bidentatae and mint;

[0039] The preservatives consist of 0.07 parts of caprylyl glycol and 0.03 parts of sorbitol;

[0040] The sugar alcohol mixture consists of 0.5 parts of xylitol and 0.5 parts of erythritol.

[0041] Preparation method of oral antibacterial paste with deep antibacterial effect, which includes the oral antibacterial paste with deep antibacterial effect as described above, and the steps are as follows:

[0042] Step 1: Material preparation

[0043] According to the required formula, accurately weigh the dosage of each medicinal material to ensure that all medicinal materials are dry, impurity-free, and of excellent quality;

[0044] Step 2: Pretreatment of medicinal materials

[0045] According to the characteristics of the medicinal materials, wash the medicinal materials to remove the dust and impurities on the surface, and pre-mix the medicinal materials for better efficacy and then concentrate. According to Step 2, mix jasmine, chrysanthemum, dandelion, licorice, tangerine peel, rehmannia root, houttuynia cordata, perilla, achyranthes bidentata, and mint in the ratio of 2%, 15%, 10%, 12%, 7%, 6%, 10%, 8%, 5%, and 25%, and concentrate to dry paste by water extraction process;

[0046] Step 3: Aqueous phase mixing

[0047] Add water, sorbitol, and glycerol to the reaction kettle, heat to 40°C, stir until dissolved, slowly add xanthan gum, homogenize until completely dispersed without particles, add the sugar alcohol mixture, and stir until dissolved. According to Step 3, the rotation speed of the homogenizer is set to 2000 rpm, and the homogenization time is set to 10 minutes;

[0048] Step 4: Oil phase mixing

[0049] Mix cocamidopropyl betaine and triclosan, and add preservatives, stir at room temperature until uniform:

[0050] Step 5: Mixing and homogenization

[0051] Slowly add the oil phase to the aqueous phase, keep the temperature constant at 45°C, mix with a homogenizer, add hydrated silica, grind with a ball mill to ensure that the paste is delicate, add plant extracts, stir at low speed to avoid bubbles. According to Step 5, the rotation speed of the homogenizer is set to 3000 rpm, the homogenization time is set to 15 minutes, and the grinding particle size of the ball mill is ≤20 μm;

[0052] Step 6: Addition of active ingredients

[0053] Cool down to below 30°C, add pediococcus pentosaceus JYPR9330, stir at low speed. According to Step 6,

[0054] Use a homogenizer to stir, turn off the high-shear function, only retain the basic stirring, the rotation speed < 100 rpm, and the stirring time is set to 5 minutes;

[0055] Step 7: Post-treatment.

[0056] Perform vacuum degassing to eliminate air bubbles, add citric acid to adjust the pH to 6.5 - 7.5, fill it into an anti-pollution pump container, store it in the dark, and set the pressure of vacuum degassing in step seven to -0.08 MPa and the time to 10 minutes.

[0057] Example 2

[0058] The present invention will be further described below in conjunction with examples.

[0059] The present invention provides an example: an oral antibacterial paste that can deeply antibacterial, comprising the following components: 25 parts of hydrated silica, 53 parts of sorbitol, 9.1 parts of water, 2.5 parts of cocamidopropyl betaine, 4 parts of glycerin, 0.9 part of xanthan gum, 0.8 part of Pediococcus pentosaceus JYPR9330, 3.5 parts of traditional Chinese medicine mixed extract, 0.1 part of preservative, 1 part of sugar alcohol mixture and 0.1 part of triclosan;

[0060] The traditional Chinese medicine mixed extract is composed of jasmine, chrysanthemum, dandelion, licorice, tangerine peel, rehmannia root, houttuynia cordata, perilla, achyranthes bidentata and mint;

[0061] The preservative is composed of 0.07 part of capryl glycol and 0.03 part of sorbitol;

[0062] The sugar alcohol mixture is composed of 0.5 part of xylitol and 0.5 part of erythritol.

[0063] The preparation method of the wound dressing for rapid treatment by applying, which includes the wound dressing for rapid treatment by applying as described above, and the steps are as follows:

[0064] Step 1: Material preparation

[0065] According to the required formula, accurately weigh the dosage of each medicinal material to ensure that all medicinal materials are dry, impurity-free and of excellent quality;

[0066] Step 2: Pretreatment of medicinal materials

[0067] According to the characteristics of the medicinal materials, wash the medicinal materials to remove the dust and impurities on the surface, and for better exerting the medicinal effect, pre-mix the medicinal materials and then concentrate them. According to step two, mix jasmine, chrysanthemum, dandelion, licorice, tangerine peel, rehmannia root, houttuynia cordata, perilla, achyranthes bidentata and mint in a ratio of 2%, 15%, 10%, 12%, 7%, 6%, 10%, 8%, 5%, 25%, and adopt the water extraction process to concentrate to dry paste;

[0068] Step 3: Aqueous phase mixing

[0069] Add water, sorbitol and glycerin into the reactor, heat to 45±5°C, stir until dissolved, slowly add xanthan gum, homogenize until completely dispersed without particles, add the sugar alcohol mixture, and stir until dissolved. According to Step 3, set the rotation speed of the homogenizer to 2000 rpm and the homogenization time to 12 minutes;

[0070] Step 4: Oil phase mixing

[0071] Mix cocoamidopropyl betaine and triclosan, and add preservatives, stir at room temperature until homogeneous:

[0072] Step 5: Mixing and homogenization

[0073] Slowly add the oil phase to the water phase, keep the temperature at 45°C constant, mix with a homogenizer, add hydrated silica, grind with a ball mill to ensure the paste is delicate, add plant extracts, stir at low speed to avoid bubbles. According to Step 5, set the rotation speed of the homogenizer to 3000 rpm, the homogenization time to 18 minutes, and the grinding particle size of the ball mill ≤20 μm;

[0074] Step 6: Addition of active ingredients

[0075] Cool down to below 30°C, add Pediococcus pentosaceus JYPR9330, stir at low speed. According to Step 6, use a homogenizer to stir, turn off the high-shear function, only retain the basic stirring, the rotation speed <100 rpm, and set the stirring time to 7 minutes;

[0076] Step 7: Post-treatment.

[0077] Perform vacuum degassing to eliminate bubbles, add citric acid to adjust the pH to 6.5 - 7.5, fill into a pollution-proof pump container, store in the dark. According to Step 7, set the pressure of vacuum degassing to -0.08 MPa and the time to 15 minutes.

[0078] The above has described the embodiments of the present invention in detail, but the present invention is not limited to the above embodiments. Within the knowledge scope of those skilled in the art, various changes can be made without departing from the purpose of the present invention.

Claims

1. An oral antibacterial cream capable of deep antibacterial properties, characterized in that: The invention comprises the following components: 15-25 parts of hydrated silica, 53-67 parts of sorbitol, 5.1-9.1 parts of water, 1.5-2.5 parts of cocamidopropyl betaine, 4-6 parts of glycerol, 0.5-0.9 parts of xanthan gum, 0.8-1.2 parts of Pediococcus pentosaceus JYPR9330, 2.5-3.5 parts of mixed extract of traditional Chinese medicine, 0.1 parts of preservative, 1 part of sugar alcohol mixture and 0.1 parts of triclosan.

2. The oral antibacterial paste capable of deep antibacterial effect according to claim 1, characterized in that: The Chinese medicine mixed extract is composed of jasmine, chrysanthemum, dandelion, liquorice, tangerine peel, radix rehmanniae, houttuynia, perilla, rhizoma achyranthis Bidentatae and mint; The preservative consists of 0.07 parts of caprylyl glycol and 0.03 parts of sorbitol; The sugar alcohol mixture consists of 0.5 parts of xylitol and 0.5 parts of erythritol.

3. A method for preparing an oral antibacterial paste capable of deep antibacterial properties, characterized in that: The method comprises the oral antibacterial paste capable of deep antibacterial effect according to claims 1 to 2, and the steps are as follows: Step 1: Material preparation According to the required formula, accurately weigh the amount of each medicinal material to ensure that all medicinal materials are dry, free of impurities and of high quality; Step 2: Pretreatment of medicinal materials According to the characteristics of the medicinal materials, the medicinal materials are cleaned to remove dust and impurities on the surface. In order to better exert the medicinal effect, the medicinal materials are pre-mixed and then concentrated; Step 3: Water phase mixing Add water, sorbitol and glycerol into a reaction kettle, heat to 45±5℃, and stir until dissolved; Slowly add xanthan gum and homogenize until it is completely dispersed without particles; Add sugar alcohol mixture and stir until dissolved; Step 4: Oil phase mixing Mix cocamidopropyl betaine and triclosan, add preservatives, and stir at room temperature until uniform: Step 5: Mixing and homogenization Slowly add the oil phase into the water phase, maintain a constant temperature of 45°C, and mix with a homogenizer; Add hydrated silica and grind using a ball mill to ensure a fine paste; Add the plant extract, stirring at low speed to avoid air bubbles; Step 6: Add active ingredients Cool down to below 30°C, add Pediococcus pentosaceus JYPR9330, and stir at low speed; Step 7: Post-processing. Perform vacuum degassing to eliminate bubbles; Add citric acid to adjust pH to 6.5-7.5; Fill into pollution-proof pump container and store away from light.

4. The method for preparing the wound healing medicine for rapid treatment according to claim 3, characterized in that: According to step 2, jasmine, chrysanthemum, dandelion, licorice, tangerine peel, raw rehmannia, houttuynia, perilla, Chinese cyperus and mint are mixed in proportions of 2%, 15%, 10%, 12%, 7%, 6%, 10%, 8%, 5% and 25%, and concentrated to a dry paste by a water extraction process.

5. The method for preparing the wound healing medicine for rapid treatment according to claim 3, characterized in that: According to step 3, the speed of the homogenizer is set to 2000 rpm, and the homogenization time is set to 10-12 minutes.

6. The method for preparing the wound healing medicine for rapid treatment according to claim 3, characterized in that: According to step five, the speed of the homogenizer is set to 3000 rpm, the homogenization time is set to 15-18 minutes, and the grinding particle size of the ball mill is ≤20 μm.

7. The method for preparing the wound healing medicine for rapid treatment according to claim 3, characterized in that: According to step six, use a homogenizer for stirring, turn off the high shear function, and only retain basic stirring, with a speed of less than 100 rpm and a stirring time of 5-7 minutes.

8. The method for preparing the wound healing medicine for rapid treatment according to claim 3, characterized in that: According to step 7, the pressure of vacuum degassing is set to -0.08 MPa and the time is set to 10-15 minutes.