Traditional Chinese medicine formula for treating cancer

Abstract

The invention discloses a traditional Chinese medicine for treating various types of cancers. The traditional Chinese medicine is prepared from fennel, lindera aggregata, kelp, seaweed, fructus psoraleae, pinellia ternate (processed), radix curcumae, ginseng, astragalus membranaceus and angelica sinensis. The medicine is compatible according to the dialectical theory of traditional Chinese medicine, has the effects of regulating qi and tonifying kidney, reducing phlegm and softening hard mass, eliminating phlegm and resolving dampness, invigorating spleen and replenishing qi, stimulating menstrual flow and removing blood stasis, dissipating hard mass and eliminating turbidity, counteracting toxic substances and resisting cancer, strengthening body resistance and eliminating evil, clearing and expelling toxin and the like, is reasonable in formula, simple in preparation process, remarkable in curative effect, convenient to use and moderate in price, and is an effective prescription for treating various types of cancers in traditional Chinese medicine.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine formula for treating various types of cancers, which has the effects of regulating qi and tonifying the kidney, resolving phlegm and softening hardness, eliminating phlegm and dampness, strengthening the spleen and replenishing qi, dredging meridians and removing stasis, dispersing hardness and eliminating turbidity, attacking toxins and anti-cancer, strengthening healthy qi and eliminating pathogenic factors, and clearing toxins and expelling poisons. Background Art

[0002] Utilize the characteristics and advantages of traditional Chinese medicine to transform the treatment means of Western medicine such as surgery, radiotherapy, and chemotherapy according to the theory of traditional Chinese medicine, give full play to the leading role of traditional Chinese medicine, and apply surgery, radiotherapy, and chemotherapy rationally, beneficially, and moderately.

[0003] Syndrome differentiation and treatment is the main method for traditional Chinese medicine to recognize and treat diseases. Treating cancer requires syndrome differentiation and treatment according to the principles of the four diagnostic methods, eight principles, theory, method, formula, and herbs of traditional Chinese medicine. According to modern medical research, any malignant tumor has its biological characteristics, roughly the same occurrence and development laws, the common basis of its morphological changes, and the common laws of pathophysiological and biochemical changes. These are the basis for disease differentiation. It is also necessary to further combine the syndrome differentiation types of traditional Chinese medicine and clarify which syndrome type the patient belongs to in order to better carry out syndrome differentiation and treatment to achieve better curative effects. Combining syndrome differentiation with disease differentiation can not only take an overall view of the situation, make a clear diagnosis, but also clarify the traditional Chinese medicine syndrome type of the patient, understand the conditions of qi and blood, yin and yang, zang-fu organs, and meridians in the body, and thus better guide the treatment. In addition, during the occurrence and development of the disease, the local and the whole are in an opposing and unified relationship. The existence of local cancer lesions causes damage to the invaded zang-fu organs, tissues, etc., and gradually affects the whole body, resulting in dysfunction and morphological changes in various systems of the whole body; conversely, the overall condition of the whole body often affects the success or failure of treatment and the effect of local treatment. Therefore, for a cancer patient, the principle of "taking both the local and the whole into consideration" needs to be followed. Summary of the Invention

[0005] The purpose of the present invention is to address the problems existing in the above technology, adopt the basic principles of traditional Chinese medicine for treating cancer of "combining disease differentiation with syndrome differentiation" and "taking both the local and the whole into consideration", and combine with years of clinical experience to obtain a traditional Chinese medicine formula with the effects of regulating qi and tonifying the kidney, resolving phlegm and softening hardness, eliminating phlegm and dampness, strengthening the spleen and replenishing qi, dredging meridians and removing stasis, dispersing hardness and eliminating turbidity, attacking toxins and anti-cancer, strengthening healthy qi and eliminating pathogenic factors, and clearing toxins and expelling poisons.

[0006] This preparation is obtained by the inventor combining a large amount of clinical experience. The present invention is made from the following traditional Chinese medicines in the following weight ratios:

[0007] Fennel 3 - 10 g, Lindera aggregata (Sims) Kosterm. 3 - 10 g, Ecklonia kurome Okamura 6 - 12 g, Sargassum fusiforme (Harv.) Setch. 10 - 18 g, Psoralea corylifolia L. 6 - 10 g, Pinellia ternata (Thunb.) Breit. (processed) 3 - 9 g, Curcuma aromatica Salisb. 6 - 15 g, Ginseng 3 - 9 g, Astragalus membranaceus (Fisch.) Bunge 10 - 20 g, Angelica sinensis (Oliv.) Diels 5 - 15 g.

[0008] The optimal weight ratio is as follows:

[0009] Fructus Foeniculi 6g, Radix Linderae 6g, Thallus Laminariae 9g, Sargassum 14g, Fructus Psoraleae 8g, Rhizoma Pinelliae (processed) 6g, Radix Curcumae 10g, Radix Ginseng 6g, Radix Astragali 15g, Radix Angelicae Sinensis 10g.

[0010] Here, the above prescriptions are explained: Among them, fennel: pungent, warm, enters the liver, kidney, spleen, and stomach meridians, has the effects of dispelling cold and relieving pain, regulating qi and harmonizing the stomach, and is used for abdominal pain caused by cold hernia, testicular prolapse, dysmenorrhea, cold pain in the lower abdomen, abdominal distension and pain, poor appetite, vomiting and diarrhea, and testicular hydrocele. Modern studies have shown that the volatile oil components in fennel have obvious antioxidant and anti-inflammatory properties, which can reduce the production of reactive oxygen free radicals in the body and inhibit the proliferation and migration of tumor cells. In addition, the coumarin compounds in fennel have anti-tumor, pro-apoptosis and anti-angiogenesis effects; Linderae rutaecarpa: pungent, warm, enters the lung, spleen, kidney, and bladder meridians. Its main effects are promoting qi and relieving pain, warming the kidney and dispelling cold. It has the effects of smoothing qi, relieving depression, dispelling cold, and relieving pain, and can regulate the spleen and stomach vital energy and pass through the Shaoyin kidney meridian. The main active ingredient of Linderae rutaecarpa is linderae ether, and it also contains linderae rutaecarpa lactone and other ingredients. Lindera odorata has multiple pharmacological effects such as anti-inflammatory, anti-tumor, and antioxidant; Kelp: salty, cold in nature, enters the liver, stomach, and kidney meridians, has the effects of eliminating phlegm, softening and dispersing stagnation, promoting diuresis and reducing swelling, and relieving fire and relieving constipation, and is used for goiter, scrofula, testicular swelling and pain, and edema caused by phlegm and fluid. "Ben Cao Jing Shu" records: "Kelp, salty can soften hardness, its nature is moistening, and cold can eliminate heat and dissipate stagnation, so it is the main 12 kinds of edema, goiter, gas accumulation, and fistula sores"; Seaweed: bitter, salty, cold in nature, enters the liver, stomach, and kidney meridians, has the effects of eliminating phlegm, softening and dispersing stagnation, promoting diuresis and reducing swelling, and is used to treat scrofula, goiter caused by phlegm and fire, testicular swelling and pain caused by phlegm and qi stagnation, edema caused by phlegm and fluid, and urination difficulties. "Compendium of Materia Medica" records: "Seaweed, salty can moisten the body, cold can dissipate heat and attract water, so it can eliminate goiter, tuberculosis, and hard masses of genitals, and eliminate edema, beriberi, retained fluid, phlegm and dampness and heat, and make the evil qi go out through urine." Kelp and seaweed are used together to complement each other, and their effects are more prominent. The power of eliminating scrofula and tumor is enhanced, which is suitable for goiter and scrofula. Psoralea corylifolia: spicy and bitter, warm in nature, mainly enters the kidney meridian and spleen meridian. It has the effects of tonifying the kidney and strengthening yang, consolidating essence and reducing urination, warming the spleen and stopping diarrhea, and relieving asthma. It is often used clinically to treat kidney deficiency and impotence, and cold pain in the waist and knees; Pinellia: warm in nature, pungent in taste, enters the spleen, stomach, and lung meridians, dries dampness and resolves phlegm, reduces adverse effects and stops vomiting, resolves phlegm and disperses nodules, and is a heat-clearing and dampness-drying medicine; Curcuma: cold in nature, pungent and bitter in taste, enters the liver, heart, and lung meridians, has the effects of promoting blood circulation and relieving pain, promoting qi and resolving scabies, clearing the heart and relieving depression, and promoting bile and relieving jaundice, and is a blood-activating and analgesic drug under the category of blood-activating and stasis-removing drugs. It is used for amenorrhea, dysmenorrhea, coma due to fever, epilepsy, jaundice, red urine, chest and abdominal distension and pain, tingling; Ginseng: sweet, slightly bitter, warm in nature, enters the lung, spleen, heart, and kidney meridians, has the effects of greatly replenishing vital energy, restoring pulse and consolidating deficiency, replenishing spleen and lung, promoting body fluid and nourishing blood, calming the mind and improving intelligence, and the saponin components in ginseng have anti-tumor effects; Astragalus: sweet, warm in nature, enters the lung and spleen meridians, has the effects of replenishing qi and consolidating the exterior, promoting diuresis and expelling toxins, expelling pus, and astringing sores and promoting tissue regeneration. It is used for qi deficiency and fatigue, poor appetite and loose stools, sinking of qi in the middle, chronic diarrhea and prolapse of the anus, bloody stool and metrorrhagia, spontaneous sweating due to superficial deficiency, edema due to qi deficiency, carbuncle is difficult to ulcerate, long-term ulcer does not heal, blood deficiency and jaundice, internal heat and thirst; Angelica: warm in nature, sweet and spicy. It enters the liver meridian, heart meridian, and spleen meridian. It has the effects of replenishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It belongs to the blood tonic medicine classified under the tonic medicine.It is used to treat sallow complexion due to blood deficiency, dizziness and palpitation, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency-cold, constipation due to intestinal dryness, rheumatic arthralgia, injury from falls, carbuncles and sores.

[0011] When the above-mentioned various herbs are used in combination, they have the effects of regulating qi and tonifying the kidney, resolving phlegm and softening hardness, eliminating phlegm and dampness, strengthening the spleen and replenishing qi, dredging meridians and removing stasis, dispersing hardness and eliminating turbidity, attacking toxins and anti-cancer, strengthening the healthy qi and eliminating pathogenic factors, clearing toxins and expelling toxins.

[0012] The traditional Chinese medicine formula of the present invention has the following advantages:

[0013] 1. The present invention is a pure traditional Chinese medicine preparation with remarkable curative effect and lasting action.

[0014] 2. The materials of the present invention are widely sourced, the manufacturing process is simple, the formula is reasonable, and the price is moderate.

[0015] 3. The present invention has no side effects and is convenient and safe to use. Specific embodiments

[0016] Example 1

[0017] Weigh each component according to the following weight parts:

[0018] Fructus Foeniculi 6g, Radix Linderae 6g, Thallus Laminariae 9g, Sargassum 14g, Fructus Psoraleae 8g, Pinellia ternata (processed) 6g, Radix Curcumae 10g, Radix Ginseng 6g, Radix Astragali 15g, Radix Angelicae Sinensis 10g.

[0019] [Manufacturing method]

[0020] Make the above components into a decoction according to the conventional well-known technology, and automatically formulate them into bags by computer. One dose of medicine is divided into 2 bags.

[0021] [Dosage and administration]

[0022] This product is taken once in the morning and once in the evening every day, 1 bag each time, orally after meals.

[0023] Example 2

[0024] Weigh each component according to the following weight parts:

[0025] Fructus Foeniculi 9g, Radix Linderae 9g, Thallus Laminariae 12g, Sargassum 16g, Fructus Psoraleae 18g, Pinellia ternata (processed) 8g, Radix Curcumae 15g, Radix Ginseng 9g, Radix Astragali 20g, Radix Angelicae Sinensis 15g.

[0026] [Manufacturing method] [Dosage and administration] are the same as in Example 1.

[0027] Example 3

[0028] Weigh each raw material according to the following weight parts:

[0029] 4g of fennel, 4g of lindera root, 7g of kelp, 12g of seaweed, 6g of psoralea fruit, 3g of processed pinellia tuber, 8g of turmeric root-tuber, 4g of ginseng, 12g of astragalus root, 6g of Chinese angelica root.

[0030] [Preparation method][Dosage and administration] The same as in Example 1.

[0031] Clinical efficacy observation

[0032] In order to observe the therapeutic effect of the present invention, the inventor selected 50 cancer patients treated with this traditional Chinese medicine formula and achieved good curative effects. The report is as follows:

[0033] 1. Clinical data

[0034] 50 cancer pain patients were clearly diagnosed according to the generally recognized diagnostic criteria in oncology. There were 27 males and 23 females, aged 24 - 81 years. Among them, there were 18 cases of lung cancer, 12 cases of esophageal cancer, 8 cases of gastric cancer, 7 cases of liver cancer, 3 cases of intestinal cancer, and 2 cases of bladder cancer. All took this traditional Chinese medicine formula.

[0035] 2. Treatment method

[0036] Weigh and make each component of this traditional Chinese medicine formula into a decoction according to the conventional well-known technology, once in the morning and once in the evening every day, 1 bag each time, orally after meals, one month as a course of treatment, and three months as a major course of treatment. Generally, it is taken for three months.

[0037] 3. Curative effect of patients

[0038] After taking the medicine for 1 - 3 months, observe the tumor situation. The treatment effects are divided into the following four types:

[0039] (1) Complete remission: It can be seen that the tumor completely disappears.

[0040] (2) Partial remission: The product of the maximum diameter and the maximum perpendicular diameter of the lesion shrinks by more than 50%, and other lesions do not increase.

[0041] (3) Stable: The product of the two diameters of the lesion shrinks by less than 50% and increases by no more than 25%.

[0042] (4) Ineffective (deterioration): The product of the two diameters of the lesion increases by more than 25%.

[0043] 4. Treatment results

[0044] (1) The following is the tumor change situation, as shown in Table 1

[0045] Table 1 Clinical treatment results of 50 cases

[0046]

[0047] The results show that the effective rate of treating various types of cancer with the present invention can reach 82%.

[0048] (2) The following is the improvement of clinical symptoms, see Table 2

[0049] Table 2 Improvement of clinical symptoms

[0050]

[0051] The results showed that the general clinical symptoms of cancer patients were improved to varying degrees after taking the Chinese medicine formula.

[0052] (3) The following are the effects on the immune indicators of cancer patients, see Table 3

[0053] Table 3 Changes in immune indicators in cancer patients

[0054]

[0055] The results show that the immunoglobulin levels of cancer patients are significantly increased after taking the Chinese medicine formula.

[0056] The results of clinical efficacy observation show that the present invention can significantly reduce the size of tumors, improve clinical symptoms of tumor patients such as mental depression, weight loss, dizziness, tinnitus, nausea, vomiting, pain, etc., and improve the immunity of patients.

[0057] The safety of the present invention is further described below through animal toxicity tests:

[0058] 1. Experimental Animals

[0059] Sexually mature Kunming mice weighing 18-22 g were selected and raised in a conventional manner with free access to food. They were purchased from the Beijing Weitonglihua Experimental Animal Technology Co., Ltd.

[0060] 2. Acute toxicity test

[0061] The modified Koch method was used to determine the LD50 of the oral acute toxicity test of this Chinese medicine formula on mice. Fifty mice were randomly divided into five groups, with 10 mice in each group, half of which were female and half were male. Each group of mice was housed in cages, with 5 mice in each cage. The groups were given 7, 14, 28, 56, and 112 g / kg at a daily dose of 2, 4, 8, 10, and 20 times the clinical dose. Each dose group was given a single oral gavage. After the administration, the feeding, drinking, breathing, activity, and death of the mice were observed and recorded for 14 consecutive days. The dead mice and the mice killed at the end of the observation period were autopsied, and pathological examinations were performed if abnormal tissues or organs were found.

[0062] 3. Long-term toxicity test

[0063] Sixty mice, with an equal number of males and females, were randomly divided into three groups: the high-dose group, the low-dose group, and the blank control group of this invention, with 20 mice in each group. The mice in each group were housed separately in cages, with 5 mice in each cage. The high-dose group was gavaged with the traditional Chinese medicine of this formula at 50 times the daily dose of clinical adults, and the low-dose group was gavaged with the traditional Chinese medicine of this formula at 10 times the daily dose of clinical adults. The blank control group was given an equal volume of distilled water, once a day for 13 consecutive weeks. The general conditions of the mice, such as food intake, behavioral activities, and feces, were observed and recorded daily. The body weight was measured once a week. After 24 hours of the last administration, 10 mice (5 males and 5 females) were selected from each group, anesthetized by intraperitoneal injection of 10% chloral hydrate, sacrificed, and the animals were dissected to observe the changes in organs such as the heart, liver, spleen, lungs, kidneys, and stomach. The remaining mice in each group were observed for two weeks after stopping the drug, and then treated in the same way, and the above indicators were observed. The obtained results were statistically processed, and the t-test was used to compare the significant differences between groups.

[0064] 4. Results

[0065] 4.1 Acute toxicity test

[0066] During the drug administration period, there were no obvious changes in the appearance signs, behavioral activities, food intake, water intake, respiration, and feces of the mice in each dose group, and none of the animals died.

[0067] 4.2 Long-term toxicity test

[0068] During the drug administration period, there were no obvious changes in the appearance signs, behavioral activities, food intake, water intake, respiration, and feces of the mice in the dose group, and none of the animals died. After 13 weeks of continuous drug administration and 2 weeks after stopping the drug, the body weights of the mice in the high-dose and low-dose groups of this formula increased normally. Compared with the blank control group, there were no significant differences in body weight changes. The results are shown in Table 4.

[0069] Table 4 Body weight changes of mice in each group (g)

[0070]

Claims

1. A Chinese medicine formula for treating various types of cancer, characterized in that The Chinese medicinal materials used are as follows: fennel, lindera strychnifolia, kelp, seaweed, psoralea corylifolia, pinellia (processed), curcuma, ginseng, astragalus, and angelica.

2. The Chinese medicine formula for treating various types of cancer according to claim 1, characterized in that According to the following weight ratio: fennel 3-10g, lindera 3-10g, kelp 6-12g, seaweed 10-18g, psoralea corylifolia 6-10g, pinellia (processed) 3-9g, turmeric 6-15g, ginseng 3-9g, astragalus 10-20g, angelica 5-15g.

3. The Chinese medicine formula for treating various types of cancer according to claim 2, characterized in that The optimal weight ratio is as follows: 6g fennel, 6g Lindera strychnifolia, 9g kelp, 14g seaweed, 8g psoralea corylifolia, 6g pinellia (processed), 10g turmeric, 6g ginseng, 15g astragalus, and 10g angelica.

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