Nutritional composition for promoting immune function recovery of patient with gastric volume reduction operation

Abstract

The invention relates to a nutritional composition for promoting immune function recovery of a patient suffering from a gastric volume reduction operation. The nutritional composition comprises protein, fat, carbohydrate, prebiotics, plant active ingredients, medicinal and edible substances, taurine, vitamins and mineral substances, the protein is a combination of at least one of pea protein and chickpea eggs and spirulina maxima protein; the fat is one or any combination of flaxseed oil micro-capsule powder, coconut milk powder, medium chain triglyceride powder and sunflower seed oil micro-capsule powder; the carbohydrate is at least one of oat fiber, brown rice starch and quinoa flour; the prebiotics are one or any combination of plantain seed husk powder, oat beta-glucan and konjaku flour; the plant active ingredients are antibacterial and anti-inflammatory compounds from natural plants; the medicinal and edible substance is a medicinal and edible medicinal material with an injury protection effect on gastric mucosa. The traditional Chinese medicine composition is specially researched and developed for vegetarian diet patients after stomach volume reduction operation, and is beneficial to enhancing the immunity and shortening the recovery phase.

Description

Technical Field

[0001] The invention belongs to the technical field of functional foods, and in particular relates to a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery. Background Art

[0002] After gastric volume reduction surgery, patients undergoing fat reduction surgery may suffer from poor nutrition and low immunity due to surgical trauma and anesthesia. The decline in immune function will reduce the body's defense ability, leading to complications such as surgery-related infections. Currently, most gastric volume reduction surgeries in clinical practice are first treated with parenteral nutrition, which is then converted to enteral nutrition after a certain period of time. Enteral nutrition can quickly improve the nutritional status of patients after gastric volume reduction surgery and restore immune function, and promote the protective effect of the intestinal mucosal barrier.

[0003] At present, the nutritional supplements after gastric volume reduction surgery mainly include high-protein nutritional supplements and complete nutritional formula powder, whose main ingredients are whey protein, casein, essential amino acids (leucine, isoleucine), vitamin B 12 , iron, collagen peptides, calcium, low lactose, Omega-3 fatty acids, probiotics, dietary fiber (inulin), vitamins and minerals and other nutrients. However, these nutritional products contain a large amount of animal ingredients (such as animal whey protein and fat), which cannot meet the needs of vegetarians. In addition, these high-protein nutritional supplements and complete nutritional formula powders mainly focus on supplementing a large amount of nutrients and the previous ones, regulating the digestive capacity of the stomach and intestines, but do not regulate the comprehensive function, immunity and metabolic capacity of the patient's body, resulting in these nutrients being difficult to be fully utilized, and even placing a greater metabolic burden on the patient's body. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] In view of the above-mentioned shortcomings and deficiencies of the prior art, the present invention provides a nutritional composition for promoting the recovery of immune function in patients undergoing gastric volume reduction surgery. The nutritional composition is mainly obtained by combining pure plant nutrients (protein, fat, carbohydrate) with prebiotics, vitamins, minerals and edible medicinal materials, thereby obtaining a nutritional composition that meets the requirements of vegetarian patients. The edible medicinal materials are used to regulate the patient's body functions, enhance immunity and metabolism, promote the absorption and utilization of nutrients, and accelerate the patient's recovery process.

[0006] (II) Technical solution

[0007] The present invention provides a nutritional composition for promoting the recovery of immune function in patients undergoing gastric volume reduction surgery, comprising protein, fat, carbohydrate, prebiotics, plant active ingredients, medicinal and edible homologous substances, taurine, vitamins and minerals;

[0008] The protein is a combination of at least one of pea protein and chickpea egg and Spirulina maxima protein; the fat is one of flaxseed oil microcapsule powder, coconut milk powder, medium-chain triglyceride powder and sunflower oil microcapsule powder, or any combination thereof; the carbohydrate is one of oat fiber, brown rice starch and quinoa powder, or any combination thereof; the prebiotic is one of psyllium husk powder, oat β-glucan and konjac flour, or any combination thereof; the plant active ingredients are antibacterial and anti-inflammatory compounds from natural plants; and the food-medicine homologous substance is a food-medicine homologous medicinal material that has a protective effect on gastric mucosa.

[0009] According to a preferred embodiment of the present invention, the plant active ingredient is one of stevia polyphenols, lemon myrtle leaves and maqui berry anthocyanins, or any combination thereof; the medicine and food homologous substances are at least two of astragalus, poria, polygonatum and licorice.

[0010] According to a preferred embodiment of the present invention, the vitamins are vitamins with anti-oxidation and anti-inflammatory auxiliary effects and / or vitamins that can promote neuromuscular function; preferably, the vitamins with anti-oxidation and anti-inflammatory auxiliary effects are at least one of vitamins A, C, and E; and the vitamins that can promote neuromuscular function are B vitamins. Preferably, the vitamins are compound vitamins containing essential vitamins for the human body.

[0011] According to a preferred embodiment of the present invention, the mineral is at least one supplement selected from calcium, iron, potassium and magnesium, such as calcium carbonate, calcium β-hydroxy-β-methyl-butyrate, magnesium oxide, potassium chloride, other compound minerals, etc. Preferably, the other compound minerals are compound minerals containing other mineral elements necessary for the human body in addition to calcium, magnesium and potassium. Potassium chloride can be used as a source of sodium ions to regulate intestinal ions.

[0012] According to a preferred embodiment of the present invention, the nutritional composition is a powder that can be brewed with water, so as to be convenient for storage, carrying and taking.

[0013] According to a preferred embodiment of the present invention, the nutritional composition comprises, by mass, 100-250 parts of protein, 50-80 parts of fat, 170-270 parts of carbohydrates, 30-60 parts of prebiotics, 3-8 parts of plant active ingredients, 5-15 parts of medicinal and edible substances, 0.5-1 part of taurine, 1-4 parts of vitamins and 30-40 parts of minerals.

[0014] According to a preferred embodiment of the present invention, the ratio of the total mass of pea protein and chickpea protein to the mass of Spirulina maxima protein in the protein is 1-3:1; preferably, the mass ratio of pea protein, chickpea protein and Spirulina maxima protein is 1:1:1, 1.5:0.5:1, 0.5:1.5:1, 2:0:1 or 0:2:1. The amino acid composition of pea protein and chickpea protein is close to that of animal whey protein, while retaining the plant nature of the protein. When combined with Spirulina maxima protein that promotes intestinal health, the amino acid composition of the protein can be close to that of animal whey protein, and the amino acids can be more easily absorbed by the intestines, solving the problem that vegetarian patients cannot ingest animal protein.

[0015] According to a preferred embodiment of the present invention, the carbohydrate is composed of at least one of oat fiber and brown rice starch combined with quinoa flour; preferably, the total mass of oat fiber and brown rice starch to the mass of quinoa flour is 13-19:5-8. These carbohydrates are low GI (glycemic index) sources of carbon water, suitable for patients in the recovery period to avoid blood sugar fluctuations; quinoa flour is a whole grain high-nutrient density food, which contains about 14g / 100g of protein and is a complete protein containing 9 essential amino acids, of which lysine (6.4mg / g) and methionine (2.3mg / g) are balanced in proportion, and its branched-chain amino acids (BCAA) account for about 20%, which promotes muscle synthesis, prevents postoperative muscle loss, and reduces the risk of gastrointestinal bloating caused by excessive intake of animal protein.

[0016] According to a preferred embodiment of the present invention, the prebiotic is composed of at least one of psyllium husk powder (soluble + insoluble, ratio of about 7:3) and konjac flour (water-soluble and highly viscous) and oat β-glucan (purely water-soluble); preferably, the ratio of the total mass of psyllium husk powder and konjac flour to oat β-glucan is 10-12:10. The prebiotic is mainly soluble dietary fiber, which can effectively promote the growth of probiotics and maintain the intestinal barrier. Compared with other dietary fibers, oat β-glucan does not require a lot of water, does not cause abdominal distension, has mild viscosity, has a low risk of gastrointestinal irritation, and will not cause fiber agglomeration due to insufficient water in the early postoperative period. Oat β-glucan has obvious advantages in regulating intestinal flora, can promote the proliferation of bifidobacteria and lactobacilli (increase 50-100%), and inhibit pathogenic bacteria (such as Escherichia coli). Oat β-glucan has a weak chelating effect on iron and zinc and does not affect the absorption of mineral elements.

[0017] According to a preferred embodiment of the present invention, the fat is composed of at least one of medium-chain triglyceride microcapsule powder and coconut milk powder, sunflower oil microcapsule powder and linseed oil microcapsule powder; wherein the ratio of the sum of the mass of medium-chain triglyceride microcapsule powder and coconut milk powder to the mass of sunflower oil microcapsule powder and linseed oil microcapsule powder is (16-25): (20-30): (20-25). These fats have little irritation to the intestine and are rich in unsaturated fatty acids (such as EPA, etc.) with anti-inflammatory effects. Medium-chain triglyceride microcapsule powder does not require bile emulsification and can be quickly absorbed by the small intestine, quickly providing energy, and playing a role in digestive system diseases (especially those with fat malabsorption). Linseed oil microcapsule powder is rich in n-3 series unsaturated fatty acids with anti-inflammatory effects, and the addition of n-6 series fatty acids in sunflower oil microcapsule powder is very gentle to the intestine. Coconut milk powder can be used as a source of fat and a substance for adjusting taste. It has a strong coconut flavor and potassium chloride is added to serve as a source of sodium ions to regulate intestinal ions.

[0018] According to a preferred embodiment of the present invention, the plant active ingredients are composed of at least one of stevia polyphenols and lemon myrtle leaves and maqui berry anthocyanins, and the total mass ratio of stevia polyphenols and lemon myrtle leaves to maqui berry anthocyanins is 1-1.5:2. These plant active ingredients have strong antioxidant and antibacterial properties, reduce free radicals, prevent postoperative infection through anti-inflammatory and antimicrobial effects, and enhance wound healing speed. Among them, maqui berry anthocyanins inhibit the NF-κB signaling pathway, reduce the secretion of proinflammatory factors TNF-α and IL-6, and simultaneously downregulate COX-2 enzyme activity, reduce prostaglandin PGE2 synthesis, inhibit Staphylococcus aureus (including MRSA) and Escherichia coli, inhibit oral pathogens (such as Streptococcus mutans), and prevent postoperative oral infections. In addition, maqui berry anthocyanins increase superoxide dismutase (SOD) activity (increase by 30%) by activating the Nrf2 / ARE pathway, reduce oxidative stress damage to new tissues, promote fibroblast migration and collagen deposition, and shorten the healing time of skin incisions.

[0019] According to a preferred embodiment of the present invention, the vitamins include vitamin A (240-300 μg / 55g), C (5-20 mg / 55g), D (0.5-1 μg / 55g), E (2-5 mg / 55g), niacin (2-5 mg / 55g), folic acid (50-80 μg / 55g), pantothenic acid (1-3 mg / 55g), B 1 (0.2-0.4mg / 55g), B 2 (0.3-0.6mg / 55g), B 6 (0.5-0.9mg / 55g), B 12 (0.1-1μg / 55g);

[0020] The minerals include sodium (300-400 mg / 55g), calcium (150-180 mg / 55g), magnesium (110-130 mg / 55g), iron (3-8 mg / 55g), zinc (1-3 mg / 55g), potassium (0.4-0.8 g / 55g), copper (0.3-0.6 mg / 55g), phosphorus (150-170 mg / 55g), iodine (5-30 μg / 55g), selenium (10-30 μg / 55g), etc. within a safe range.

[0021] (III) Beneficial effects

[0022] The technical effects of the present invention are:

[0023] (1) The present invention is specially developed for the recovery of gastrointestinal immune function in vegetarian patients after gastric volume reduction surgery. Its ingredients include 8 categories of ingredients, namely, protein, fat, carbohydrate, prebiotic, plant active ingredients, medicinal and edible substances, vitamins and minerals. Among them, protein adopts high-quality protein sources such as pea protein and chickpea protein whose amino acid composition is close to that of animal whey protein, and is combined with spirulina protein that can promote intestinal function recovery to replace animal protein; the high-quality protein ratio is high, which is more conducive to restoring positive nitrogen balance; the fat adopts fatty acids with low intestinal irritation and unsaturated fatty acids of plant origin with good anti-inflammatory properties. The entire nutritional composition does not contain any animal protein and fat, meets the needs of vegetarian patients for postoperative immune function recovery, and fills the gap in similar products.

[0024] (2) The nutritional composition of the present invention is different from the existing pure high-protein nutritional supplements and complete nutritional formula powders. In addition to protein, fat, minerals, prebiotics, etc., it also adds plant active ingredients with specific functions and medicinal and edible substances. While supplementing nutrition, these antioxidant, anti-inflammatory and antibacterial plant active ingredients help reduce postoperative infection and promote wound recovery. These medicinal and edible substances are used to promote gastrointestinal health, regulate the comprehensive function and metabolic capacity of the patient's body, increase the patient's immunity, and indirectly improve the absorption and utilization effect of other nutrients, quickly restore the patient's physical strength and various physical indicators. Compared with products that simply provide nutrients, the present invention helps to avoid the additional burden on the patient's digestive system caused by consuming more high-density nutrients in a short period of time. In addition, medicinal and edible substances also provide a small amount of dietary fiber and natural minerals and other elements, which are more easily absorbed and utilized. At the same time, the addition of these plant active ingredients also helps to improve the stability of nutrients (such as n-3 unsaturated fatty acids, vitamins C and E).

[0025] (3) In the nutritional composition of the present invention, carbohydrates and prebiotics have been strictly and scientifically selected and assembled, wherein carbohydrates are low glycemic index carbohydrates oat fiber, quinoa powder and brown rice starch, which are suitable for vegetarian patients to recover after surgery. These carbohydrates release energy slowly and avoid blood sugar fluctuations. The added prebiotics psyllium husk powder, oat β-glucan and konjac powder are mostly soluble dietary fiber, which is more likely to produce a sense of fullness, and is mild and less irritating, does not expand (not easy to cause intestinal flatulence), has low requirements for drinking water, and is not easy to cause intestinal dryness. Prebiotics are degraded in the human intestine to produce short-chain fatty acids, which can enhance the sodium ion exchange of colon mucosal cells and improve the diarrhea effect of patients. Some oligosaccharides can increase the concentration of immunoglobulins in the cecum and improve the body's immunity.

[0026] (4) In the nutritional composition of the present invention, the fat is composed of at least one of medium-chain triglyceride microcapsule powder and coconut milk powder, sunflower oil microcapsule powder and linseed oil microcapsule powder. Medium-chain triglyceride microcapsule powder does not require bile emulsification and can be quickly absorbed by the small intestine, quickly providing energy, and is very friendly to digestive system diseases (especially those with fat absorption disorders); linseed oil is rich in n-3 series unsaturated fatty acids and has good anti-inflammatory effects, and sunflower oil is rich in n-6 series fatty acids, which are irritating to the intestine; small coconut milk powder is used as a source of fat to adjust the taste of the nutritional powder, so that the nutritional powder has a strong coconut flavor, and improves product acceptance and popularity.

[0027] Preferably, by adjusting the ratio of sunflower oil and linseed oil, the mass ratio of n-6 series polyunsaturated fatty acids to n-3 series polyunsaturated fatty acids in the nutritional powder is 2.5:1. This ratio is specially set for people in the recovery period after gastric volume reduction surgery, and the ratio of n-3 is increased, which is more conducive to the anti-inflammatory effect of gastrointestinal surgery patients in the recovery period. The ratio of n-6 series polyunsaturated fatty acids to n-3 series polyunsaturated fatty acids is usually 4-6:1 for the general population. DETAILED DESCRIPTION

[0028] In order to better explain the present invention and facilitate understanding, the present invention is described in detail below in conjunction with specific implementation methods.

[0029] The functions of the main ingredients in the nutritional composition of the present invention are as follows:

[0030] (1) Protein: Chickpea protein and pea protein provide high-quality protein close to animal whey protein. They are rich in amino acids, such as arginine, which plays a vital role in protein synthesis during wound healing.

[0031] Arthrospira maxima protein contains chlorophyll, which helps repair the gastrointestinal mucosa. Due to its unique nutritional composition and biological activity, Arthrospira maxima protein plays multiple roles in the rehabilitation of patients after gastrointestinal surgery, such as promoting tissue repair, regulating immune response, and improving the intestinal microenvironment. Arthrospira maxima protein has a high content of 8 essential amino acids and a biological value (BV) of 75-85, which is close to whey protein (BV=104). The glutamine it provides can promote the regeneration of intestinal mucosal cells and shorten the recovery time of intestinal barrier function after surgery. Spirulina has a thin cell wall (mainly composed of galactan) and a high protein digestibility, which is suitable for patients with postoperative gastrointestinal insufficiency. Phycocyanin reduces the levels of postoperative proinflammatory factors IL-6 and TNF-α by inhibiting the NF-κB signaling pathway, reducing the damage of oxidative stress to the wound. Rhamnose polysaccharide in spirulina promotes the proliferation of bifidobacteria and inhibits conditional pathogens. The protein selected by the present invention is a plant-derived protein, which can not only replace animal protein well, but also help to improve the body's immunity and reduce the occurrence of infection, thus facilitating faster healing of postoperative wounds.

[0032] (2) Fat: The role of medium-chain triglycerides (MCT) in postoperative repair is mainly reflected in promoting the recovery of postoperative patients and improving the nutritional status. Unlike long-chain triglycerides, MCT does not need to rely on bile acid emulsification, but directly enters the liver through the portal vein for oxidation and energy supply, providing immediate energy for weak patients after surgery. Its energy supply efficiency is much higher than that of long-chain fatty acids, avoiding the lipid absorption pressure of long-chain fatty acids (LCT) on the damaged intestine after surgery and reducing the burden on the lymphatic system caused by chylomicron accumulation.

[0033] α-linolenic acid (ALA) is converted into EPA / DHA in the liver, inhibiting the production of pro-inflammatory factors PGE2 and LTB4, reducing the risk of postoperative infection. Microencapsulation protects ALA from gastric acid damage and improves bioavailability. Flaxseed oil microencapsulated powder is rich in n-3 series of unsaturated fatty acids, which can promote wound healing and reduce postoperative infection. It can also support overall postoperative recovery by providing necessary nutrition and regulating immune function.

[0034] Coconut milk powder is rich in medium-chain fatty acids (such as lauric acid), which can inhibit Staphylococcus aureus and inhibit the formation of biofilm on surgical incisions. Coconut milk powder is rich in vitamin E, which has antioxidant and antibacterial effects, helps prevent infection and promote wound healing.

[0035] Sunflower oil microcapsule powder is rich in n-6 fatty acids and has little irritation to the intestines. The linoleic acid (LA) it contains can be converted into γ-linolenic acid (GLA) and arachidonic acid (AA), participating in cell membrane construction and eicosanoid synthesis, maintaining postoperative energy metabolism balance, stimulating intestinal epithelial cell proliferation, and accelerating mucosal repair.

[0036] (3) Carbohydrates: Oat fiber, quinoa flour, and brown rice starch are the main sources of carbohydrates, all of which have a low GI, providing a stable energy supply after surgery and avoiding blood sugar fluctuations. Soluble oat fiber forms a gel in the stomach, delaying gastric emptying, reducing hunger in the early postoperative period, and reducing the risk of dumping syndrome. Oat fiber can generate short-chain fatty acids (SCFA), which are fermented in the colon to produce butyric acid, promote intestinal mucosal repair, and reduce the incidence of postoperative intestinal leakage.

[0037] Quinoa powder contains 9 essential amino acids with a bioavailability of 80%, which can make up for the lack of protein intake after surgery. Quinoa is rich in iron and magnesium, which can prevent postoperative anemia and relieve postoperative muscle weakness.

[0038] Brown rice starch can provide sustained energy and is fortified with B vitamins. Brown rice starch contains GABA, which can improve irritable gastrointestinal dysfunction. Quinoa contains saponins, which may cause mild intestinal irritation. Desaponinized quinoa powder is preferred.

[0039] (4) Prebiotics: Prebiotics provide nutrition and energy to beneficial intestinal bacteria, promote the growth of beneficial bacteria, help maintain the balance of intestinal flora, inhibit the growth of harmful bacteria, thereby protecting the intestinal barrier function and reducing the risk of postoperative infection. Postoperative patients may experience constipation due to reduced activity or the use of certain medications. Prebiotics can promote intestinal peristalsis and prevent constipation. Prebiotics are fermented by intestinal bacteria in the large intestine, and the short-chain fatty acids produced can provide energy for intestinal epithelial cells, which helps wound healing and tissue repair. Probiotics can improve intestinal function by regulating immune responses, inhibiting the growth of harmful bacteria, and promoting intestinal nutrient absorption.

[0040] (5) Phytoactive ingredients: Stevia polyphenols, lemon myrtle leaf, and maqui berry anthocyanins phytochemicals reduce free radicals through their antioxidant capacity, thereby enhancing wound healing. They can also prevent postoperative infections through anti-inflammatory and antimicrobial effects. These active ingredients can also improve product stability.

[0041] (6) Food and medicine substances: Polygonatum sibiricum, Poria cocos, Astragalus membranaceus and Licorice root have the function of repairing gastrointestinal mucosa. The combination of Polygonatum sibiricum, Poria cocos, Astragalus membranaceus and Licorice root with modern nutritional components such as protein, fat and prebiotics can form a postoperative rehabilitation program of "tonifying-repairing-metabolism regulation". Polygonatum sibiricum polysaccharide and steroidal saponin can increase liver glycogen reserve, improve postoperative glucose metabolism disorder and inhibit excessive inflammation. Poria cocos polysaccharide and triterpenoids can enhance the expression of intestinal tight proteins (ZO-1 and Occludin), repair the intestinal mucosal barrier and promote the proliferation of bifidobacteria. Astragaloside I and calycosin promote protein synthesis in the body. Glycyrrhizic acid and glycyrrhetinic acid antagonize excessive secretion of postoperative cortisol and reduce muscle breakdown; neutralize free radicals and protect the mitochondrial function of liver cells. Astragalus membranaceus can enhance the utilization rate of branched-chain amino acids (BCAA) in quinoa powder and promote postoperative nitrogen balance. Poria cocos can enhance the efficiency of ketone body production of medium-chain triglycerides and provide alternative energy for the brain. Glycyrrhizic acid inhibits COX-2 and synergizes with EPA in linolenic acid to reduce the level of thromboxane A2 (TXA2) after surgery and prevent venous thrombosis. These edible and medicinal substances can also provide oligosaccharides and have prebiotic effects. The medicinal and medicinal substances have a light taste and are non-toxic, and can be eaten as food without affecting the taste of the nutritional composition.

[0042] (7) Minerals and vitamins: Vitamins play a vital role in the postoperative recovery process. Vitamin A helps promote growth and maintain the normal function of epithelial tissue and maintain the integrity of the skin and mucous membranes; B vitamins help maintain the health of the skin and mucous membranes. Vitamin C can promote the body's metabolism and is beneficial to the healing of incisions after surgery. Vitamin D helps the body absorb calcium. Vitamin E has antioxidant, anti-aging, skin protection, and blood circulation effects. Zinc in minerals can promote wound healing, and iron is essential for the formation of red blood cells and oxygen transport. After surgery or during recovery, iron supplementation can help prevent anemia and help restore body functions.

[0043] The present invention compounds the above components in a suitable ratio, which is beneficial to the recovery of gastrointestinal immune function of vegetarian patients after surgery.

[0044] The following is a description of the preferred embodiments of the present invention. In the following embodiments, unless otherwise specified, all refer to mass fractions, proportions refer to mass ratios, and % refers to mass percentages.

[0045] Example 1

[0046] This embodiment provides a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery, and its composition is shown in Table 1:

[0047] Table 1:

[0048]

[0049] 1. The nutritional composition of the nutritional powder produced according to the above formula is shown in Table 2 (the ratio of linoleic acid (n-6 fatty acid) to linolenic acid (n-3 fatty acid) is 2.5):

[0050] Table 2:

[0051]

[0052]

[0053] Example 2

[0054] This embodiment provides a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery, and its composition is shown in Table 3:

[0055] Table 3:

[0056]

[0057]

[0058] Example 3

[0059] This embodiment provides a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery, and its composition is shown in Table 4:

[0060] Table 4:

[0061]

[0062] Example 4

[0063] This embodiment provides a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery, wherein the protein composition is: 60 parts of pea protein, 30 parts of chickpea protein, and 30 parts of Spirulina maxima protein, a total of 120 parts. The remaining composition is the same as that of Example 1.

[0064] Example 5

[0065] This embodiment provides a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery, wherein the protein composition is: 50 parts of pea protein, 50 parts of chickpea protein, and 100 parts of Spirulina maxima protein, a total of 200 parts. The remaining composition is the same as that of Example 1.

[0066] Example 6

[0067] This embodiment provides a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery, wherein the carbohydrate composition is: 100 parts of oat fiber, 50 parts of brown rice starch, and 70 parts of quinoa flour, a total of 220 parts. The remaining composition is the same as that of Example 1.

[0068] Example 7

[0069] This embodiment provides a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery, wherein the fat composition is: 25 parts of TMC, 30 parts of sunflower seed oil microcapsule powder, and 25 parts of linseed oil microcapsule powder, a total of 80 parts. The remaining composition is the same as that of Example 1.

[0070] Example 8

[0071] This embodiment provides a nutritional composition for promoting immune function recovery in patients undergoing gastric volume reduction surgery, wherein the prebiotic composition is 24 parts of psyllium husk powder, 4.8 parts of konjac flour, and 24 parts of oat β-glucan, totaling 52.8 parts. The remaining composition is the same as that of Example 1.

[0072] Comparative Example 1

[0073] The difference between this comparative example and Example 1 is that this comparative example does not add plant active ingredients and medicinal and edible substances, and uses maltodextrin to make up for the quality difference of "plant active ingredients and medicinal and edible substances". The rest of the composition is the same as Example 1.

[0074] Comparative Example 2

[0075] The difference between this comparative example and Example 1 is that the fat composition is changed: the "29 parts of sunflower oil microcapsule powder, 8 parts of MCT microcapsule powder, 20 parts of flaxseed microcapsule powder, and 8 parts of coconut milk powder" in Example 1 are changed to "37.5 parts of sunflower oil powder, 8 parts of medium-chain triglyceride microcapsule powder, 8 parts of coconut milk powder, and 11.5 parts of flaxseed oil powder". After changing the fat composition, the mass ratio of the sum of the medium-chain triglyceride microcapsule powder and coconut milk powder to the mass ratio of the sunflower oil microcapsule powder and the flaxseed oil microcapsule powder becomes 16:37.5:11.5.

[0076] Comparative Example 3

[0077] The difference between this comparative example and Example 1 is that the fat composition is changed: the "29 parts of sunflower oil microcapsule powder, 8 parts of MCT microcapsule powder, 20 parts of flaxseed microcapsule powder, and 8 parts of coconut milk powder" in Example 1 are changed to "19 parts of sunflower oil powder, 8 parts of medium-chain triglyceride microcapsule powder, 8 parts of coconut milk powder, and 30 parts of flaxseed oil powder". After changing the fat composition, the mass ratio of the sum of the medium-chain triglyceride microcapsule powder and coconut milk powder to the mass ratio of the sunflower oil microcapsule powder and the flaxseed oil microcapsule powder becomes 16:19:30.

[0078] Compared with Example 1, the linoleic acid content is 1.23g / 55g nutritional powder, and the α-linolenic acid content is 495mg / 55g nutritional powder, wherein 2.48:1, wherein the content of α-linolenic acid (n-3 unsaturated fatty acid) is relatively high, and n-3 series unsaturated fatty acids have a good effect of inhibiting inflammation in vivo. In Comparative Example 2, after adjusting the fat composition, the linoleic acid contained therein is 1.47g / 55g nutritional powder, the α-linolenic acid content is 290mg / 55g nutritional powder, and the ratio of n-6 fatty acid to n-3 fatty acid becomes 5.07:1, which can better meet the daily needs of ordinary people; in Comparative Example 3, after adjusting the fat composition, the linoleic acid contained therein is 955mg / 55g nutritional powder, the α-linolenic acid content is 959mg / 55g nutritional powder, and the ratio of n-6 fatty acid to n-3 fatty acid becomes 1:1, in which case the content of n-3 fatty acid is too high, which may cause α-linolenic acid to be unable to be fully utilized.

[0079] Comparative Example 4

[0080] The difference between this comparative example and Example 1 is that the composition of the protein is changed: the "80 parts of chickpea protein, 80 parts of pea protein, and 80 parts of spirulina maxima protein" in Example 1 is changed to "40 parts of chickpea protein, 40 parts of pea protein, and 160 parts of spirulina maxima protein". After the protein composition is changed, the total mass ratio of chickpea protein and pea protein to spirulina maxima protein is 1:2.

[0081] Comparative Example 5

[0082] The difference between this comparative example and Example 1 is that the composition of prebiotics is changed: the "15 parts of psyllium husk powder, 20 parts of oat β-glucan, and 7 parts of konjac flour" in Example 1 is changed to "20 parts of psyllium husk powder and 22 parts of konjac flour". After changing the composition of prebiotics, the completely pure water-soluble β-glucan is removed, and the psyllium husk powder left is partially water-soluble dietary fiber and water-soluble high-viscosity konjac flour.

[0083] The products obtained in Examples 1-3 and Comparative Examples 1-3 and 5 were subjected to sensory evaluation. The evaluation panel consisted of 20 people and scored from four aspects: sweetness, saltiness, taste, and solubility. The percentage scoring standard is shown in Table 5; the scoring results are shown in Table 6.

[0084] Table 5: Scoring criteria table

[0085]

[0086] Table 6: Scoring results

[0087]

[0088]

[0089] The nutritional powders of Examples 1-3 and Comparative Examples 1-3 have good taste, rich aroma, no peculiar smell, are easy to prepare, have no precipitation after preparation, and have suitable sweetness, with comprehensive scores of 92, 93, 91, 92, and 90 points. It can be seen that the plant compounds and medicinal and edible substances added in the embodiments of the present invention do not affect the overall sensory perception of the product. However, the reconstitution and sweetness scores of Comparative Example 5 decreased, which indicates that reducing the proportion of pure water-soluble β-glucan in prebiotics is not conducive to improving the reconstitution and sweetness scores of the nutritional powder.

[0090] Animal experiments

[0091] 1. 40 male SPF BALB / C mice weighing 18-22g were selected and grouped into blank control group, positive control group, Example 1-3 group, Comparative Example 1-3 group, 8 groups in total, all 40 mice underwent partial intestinal resection surgery, and all underwent the same parenteral nutrition and postoperative anti-infection. After switching from parenteral nutrition to enteral nutrition, the 8 groups of mice were gavaged with different methods, and the Example 1-3 group was gavaged with 10mL / kg of the Example 1-3 sample dilution (1:10 dilution), the Comparative Example 1-3 group was gavaged with 10mL / kg of the Comparative Example 1-3 sample dilution (1:10 dilution), the blank control group was gavaged with the same dose of normal saline, and the positive control group was gavaged with the same dose of Pepi-2000. The changes in the weight of the mice were tested for 2 weeks. The results are shown in Table 7.

[0092] Table 7: Results of measurement of mouse body weight, thymus and spleen indexes

[0093]

[0094]

[0095] *P<0.05, compared with the blank control group; #p<0.05, compared with the positive control group.

[0096] As can be seen from Table 7, compared with the blank control group, the weight of the mice in Examples 1-3 and Comparative Examples 1-3 increased. Compared with the positive control group, Baipusu, the weight increase of the mice in Examples 1-3 was greater, while the weight increase of the mice in Comparative Examples 1-3 was relatively small. The development of the spleen and thymus can reflect the immune status of the mice. Compared with the blank control group, the spleen / body weight and thymus / body weight indexes of Examples 1-3 and Comparative Examples 1-3 increased, indicating that the postoperative immune status of the mice was good, and compared with the positive control group Baipusu, the spleen / body weight and thymus / body weight values ​​of the mice in Examples 1-3 increased more. At the same time, the increase in the corresponding indicators of Comparative Examples 1-3 was relatively small. This shows that Examples 1-3 of the present invention have a better effect on the recovery of the immunity of mice; and after the nutritional composition lacks n-3 fatty acids or plant active ingredients with anti-inflammatory and antioxidant properties and medicinal and edible homologous substances with functional regulation functions, the product will weaken the recovery effect of the postoperative immune status of mice.

[0097] 2. Based on the above experiments, the effects of the nutritional compositions of Examples 1-3 and Comparative Examples 1-3 on the function of mononuclear macrophages in mice were further investigated. After 2 weeks of intragastric administration, the function of mononuclear macrophages in mice was tested. The results are shown in Table 8.

[0098] Table 8: Test results of monocyte-macrophage phagocytic function

[0099]

[0100]

[0101] Note: *P<0.05, compared with the blank control group; #p<0.05, compared with the positive control group.

[0102] As can be seen from Table 8, compared with the control group and the positive control group, the phagocytic rate and phagocytic index of the monocyte-macrophages in Examples 1-3 were significantly increased (P < 0.05), which shows that the nutritional composition of the present invention can indeed significantly improve the phagocytic function of the monocyte-macrophages in mice. Compared with the blank control group, the phagocytic rate and phagocytic index of the monocyte-macrophages in Comparative Examples 1-3 were also increased (P < 0.05), but compared with the positive control group, the phagocytic rate and phagocytic index of the monocyte-macrophages in Comparative Examples 1-3 were relatively low. This shows that the nutritional composition of Examples 1-3 of the present invention has a better effect on the improvement of the mouse immune system than the positive control group; and although the comparative example also has a certain effect, its effect is not as good as the positive control group.

[0103] 3. According to the same intragastric gavage experimental method as above, but the experimental samples were changed to Examples 4-8 and Comparative Examples 1, 4-5; after 2 weeks of intragastric gavage experiment, the effects of the nutritional compositions of Examples 4-8 and Comparative Examples 1, 4-5 on the proliferation capacity of mouse spleen lymphocytes were tested. The test results are shown in Table 9.

[0104] Table 9: Splenic lymphocyte proliferation ability test results

[0105]

[0106]

[0107] *P<0.05, compared with the blank control group; #p<0.05, compared with the positive control group.

[0108] As can be seen from Table 9, compared with the OD values ​​of the control group and the positive control group, Examples 4-8 showed significant increases, which indicates that the nutritional composition of the present invention can indeed improve the proliferation capacity of spleen lymphocytes in mice after surgery, and has a significant effect on improving the immunity of mice, and is superior to the prior art (Bipusu in the positive control group); each comparative example can also improve the proliferation capacity of spleen lymphocytes in mice, but the effect is not as good as that of the positive control group.

[0109] In summary, the nutritional composition of the present invention has a good promoting effect on the weight gain, spleen, thymus, etc. of postoperative mice, and has a positive and significant promoting effect on the spleen lymphocyte proliferation ability and monocyte-macrophage function of mice, which shows that the nutritional composition of the present invention can well improve the immunity of postoperative mice; among them, the composition of fatty acids, plant active ingredients with anti-inflammatory and improvement effects on intestinal repair, medicinal and edible substances, protein composition, prebiotic composition and other elements all play an important role in the efficacy of the nutritional composition.

[0110] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the above embodiments, those skilled in the art should understand that the technical solutions described in the above embodiments may still be modified, or some or all of the technical features therein may be replaced by equivalents. These modifications or replacements, or the technical features in the above embodiments may be combined in the manner described in the embodiments if they do not conflict with each other, and these modifications, replacements or combinations do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A nutritional composition for promoting the recovery of immune function in patients undergoing gastric volume reduction surgery, characterized in that: It contains proteins, fats, carbohydrates, prebiotics, plant active ingredients, medicinal and edible substances, taurine, vitamins and minerals; The protein is a combination of at least one of pea protein and chickpea egg and Spirulina maxima protein; the fat is one of flaxseed oil microcapsule powder, coconut milk powder, medium-chain triglyceride powder and sunflower oil microcapsule powder, or any combination thereof; the carbohydrate is one of oat fiber, brown rice starch and quinoa powder, or any combination thereof; the prebiotic is one of psyllium husk powder, oat β-glucan and konjac flour, or any combination thereof; the plant active ingredients are antibacterial and anti-inflammatory compounds from natural plants; and the food-medicine homologous substance is a food-medicine homologous medicinal material that has a protective effect on gastric mucosa.

2. The nutritional composition according to claim 1, characterized in that The plant active ingredient is one of stevia polyphenols, lemon myrtle leaves and maqui berry anthocyanins or any combination thereof; the medicine and food homologous substances are at least two of astragalus, tuckahoe, polygonatum and licorice.

3. The nutritional composition according to claim 1, characterized in that The nutritional composition is a powder that can be brewed with water.

4. The nutritional composition according to claim 1, characterized in that The nutritional composition comprises, by weight, 100-250 parts of protein, 50-80 parts of fat, 170-270 parts of carbohydrates, 30-60 parts of prebiotics, 3-8 parts of plant active ingredients, 5-15 parts of medicinal and edible substances, 0.5-1 part of taurine, 1-4 parts of vitamins and 30-40 parts of minerals.

5. The nutritional composition according to claim 4, characterized in that The ratio of the total mass of pea protein and chickpea protein to the mass of spirulina maxima protein in the protein is 1-3:

1.

6. The nutritional composition according to claim 4, characterized in that The carbohydrate is composed of at least one of oat fiber and brown rice starch and quinoa powder; wherein the ratio of the total mass of the oat fiber and brown rice starch to the mass of the quinoa powder is 13-19:5-8.

7. The nutritional composition according to claim 4, characterized in that The prebiotics are composed of at least one of psyllium husk powder and konjac flour and oat beta-glucan; wherein the ratio of the total mass of psyllium husk powder and konjac flour to the oat beta-glucan is 10-12:

10.

8. The nutritional composition according to claim 4, characterized in that The fat is composed of at least one of medium-chain triglyceride microcapsule powder and coconut milk powder, sunflower seed oil microcapsule powder and linseed oil microcapsule powder; wherein the ratio of the total mass of the medium-chain triglyceride microcapsule powder and coconut milk powder to the mass of the sunflower seed oil microcapsule powder and linseed oil microcapsule powder is (16-25):(20-30):(20-25).

9. The nutritional composition according to claim 4, characterized in that The plant active ingredient is composed of at least one of stevia polyphenols and lemon myrtle leaves in combination with maqui berry anthocyanins, and the mass ratio of the total mass of stevia polyphenols and lemon myrtle leaves to the mass of maqui berry anthocyanins is 1-1.5:2.

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