A skin care composition with sleep-aiding and anti-aging effects and preparation method thereof

Abstract

The present invention relates to a skin care composition with sleep-aiding and anti-aging effects and a preparation method thereof. The skin care composition with sleep-aiding and anti-aging effects includes the following components in parts by mass: 3-15 parts of moisturizing agent, 1-3 parts of emulsifier, 3-10 parts of chitosan, 0.5-4 parts of anti-aging active ingredients, 0.5-4 parts of sleep-aiding active ingredients, 1-5 parts of cross-linking agent, 0.5-2 parts of antioxidant, and 40-90 parts of solvent; wherein, the chitosan includes hydrophilized chitosan and hydrophobized chitosan. The present invention uses hydrophobic and hydrophilic modified chitosan to coat anti-aging and sleep-aiding active ingredients to obtain microspheres, which are then applied to the skin care composition, not only improving the stability of the product, but also being able to more efficiently exert its efficacy when used, and also having multiple effects such as moisturizing and emollient, and has good application prospects.

Description

Technical Field

[0001] The present invention relates to the technical field of cosmetics, and in particular to a skin care composition with sleep-aiding and anti-aging effects and a preparation method thereof. Background Art

[0002] With the increasing global aging population and rising health awareness, the market for sleep and anti-aging products is growing rapidly. The demand for sleep-aiding, calming, and anti-aging products from a large number of people with sleep disorders and beauty consumers is driving product diversification. Oral tablets, beverages, and inhaled formulations are currently the mainstream forms of sleep and anti-aging products. Products that combine sleep-aiding and anti-aging ingredients with skincare products are also a hot topic of research.

[0003] Existing technologies such as CN109200176A, an anti-aging sleep-aiding wine, CN119385982A, a non-addictive anti-aging sleep-aiding preparation and its preparation method, CN119699589A, a composition containing ergothioneine with sleep-aiding, whitening, anti-aging and anti-inflammatory effects and its application, etc., all use a variety of different substances with sleep-aiding and anti-aging functions to compound, and are applied to beverages, food and other fields, and have achieved certain sleep-aiding and anti-aging effects.

[0004] However, active ingredients such as plant extracts are easily affected by light, heat, oxygen and humidity, and may be degraded or inactivated. Their effects are significantly reduced after long-term storage. To improve stability, the industry often uses microencapsulation technology, using cyclodextrin, liposomes, chitosan and other wall materials to encapsulate active ingredients and isolate them from the external environment. However, this protection mechanism may delay the release of active ingredients, resulting in the product not being able to take effect and be absorbed in time, and is not suitable for use in skin care products. In addition, most encapsulation technologies still have shortcomings such as unsatisfactory results, complex processes and high costs, and still need to be further optimized to meet the market demand for efficient and stable sleep-aiding and anti-aging products.

[0005] Therefore, it is urgent to develop a new technical solution to solve the problems existing in the existing technology. Summary of the Invention

[0006] Based on this, the present invention provides a skin care composition with sleep-inducing and anti-aging effects and a preparation method thereof. The present invention uses hydrophobically and hydrophilically modified chitosan to coat anti-aging and sleep-inducing active ingredients to produce microspheres, which are then applied to the skin care composition. This not only improves product stability but also enables more efficient efficacy during use. It also has multiple benefits, such as moisturizing and emollient effects, and has promising application prospects.

[0007] One object of the present invention is to provide a skin care composition having sleep-aiding and anti-aging effects, wherein the skin care composition having sleep-aiding and anti-aging effects comprises the following components in parts by weight:

[0008] 3-15 parts moisturizer

[0009] 1-3 parts emulsifier

[0010] 3-10 parts chitosan

[0011] 0.5-4 parts of anti-aging active ingredients

[0012] 0.5-4 parts of sleep-aiding active ingredients

[0013] 1-5 parts crosslinking agent

[0014] 0.5-2 parts antioxidant

[0015] 40-90 parts of solvent;

[0016] Wherein, the chitosan includes hydrophilic chitosan and hydrophobic chitosan.

[0017] Furthermore, the mass ratio of the hydrophilized chitosan to the hydrophobized chitosan is 1:(0.1-5).

[0018] Furthermore, the anti-aging active ingredients include resveratrol, quercetin, and ergothioneine; the sleep-aiding active ingredients include jujube saponin, linalyl acetate, and theanine.

[0019] Furthermore, the moisturizing agent includes glycerin, butylene glycol and sodium hyaluronate.

[0020] Furthermore, the hydrophilized chitosan is hydroxypropyl chitosan; and the hydrophobized chitosan is polylactic acid-modified chitosan.

[0021] Furthermore, the preparation method of the polylactic acid modified chitosan comprises the following steps:

[0022] Chitosan and lactic acid are mixed, heated and dehydrated, a catalyst is added, and vacuum heating reaction is performed to obtain polylactic acid modified chitosan.

[0023] Furthermore, the temperature of the heating dehydration is 70-120°C, and the temperature of the vacuum heating is 120-130°C.

[0024] Furthermore, the mass ratio of chitosan to lactic acid is 1:(10-50).

[0025] The polylactic acid modified chitosan of the present invention directly reacts lactic acid and chitosan by mixing them. Under the action of a catalyst, the carboxyl groups of the polylactic acid and the amino groups of the chitosan undergo an amidation reaction to obtain modified chitosan with introduced polylactic acid segments. The preparation process is simple, and the obtained product has better film-forming and coating properties, promotes the encapsulation of active substances to form microspheres, and at the same time has stronger hydrophobicity, thereby improving the stability of the composition.

[0026] Another object of the present invention is to provide a method for preparing the above-mentioned skin care composition having sleep-aiding and anti-aging effects, wherein the method for preparing the skin care composition having sleep-aiding and anti-aging effects comprises the following steps:

[0027] S1. Add chitosan to acetic acid, then add the anti-aging active ingredient and the sleep-inducing active ingredient with stirring, then add a cross-linking agent, stir to react, and dry to obtain an intermediate product;

[0028] S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

[0029] Furthermore, the temperature of the stirring reaction is 20-30°C.

[0030] Furthermore, the cross-linking agent is sodium tripolyphosphate.

[0031] The present invention has the following beneficial effects:

[0032] The present invention provides a skin care composition with sleep-inducing and anti-aging effects, comprising chitosan-coated sleep-inducing and anti-aging active ingredients, and compounded with a moisturizer and other ingredients. The chitosan is composed of hydrophilic hydroxypropyl chitosan and hydrophobic lactic acid-modified chitosan. On the one hand, the active groups and long chain segments therein promote adsorption and encapsulation of the active ingredients, facilitating the formation of microspheres. On the other hand, after the two chitosans encapsulate the active ingredients and cross-link to form microspheres, they possess both hydrophilic and hydrophobic properties, improving compatibility with other components and solvents, enhancing the stability of the emulsion composition, and reducing the possibility of active ingredient loss after long-term storage. Furthermore, the chitosan-coated active ingredient microspheres of the present invention have good affinity with the skin. During use, massage and friction can more efficiently promote the release and absorption of the active substance (this may be related to the reduced thermal stability of hydroxypropyl chitosan and lactic acid-modified chitosan compared to unmodified chitosan), resulting in more significant improvements in skin health and sleep quality. In summary, the skin care composition with sleep-aiding and anti-aging effects of the present invention overcomes the defects existing in the prior art and provides a new idea for the development of skin care and health care products. DETAILED DESCRIPTION

[0033] In order to more clearly illustrate the technical solutions of the present invention, the following examples are given. Unless otherwise stated, the raw materials, reactions and post-processing methods mentioned in the examples are common raw materials on the market and technical methods well known to those skilled in the art.

[0034] The terms "preferred," "preferably," "more preferred," and the like, used herein, refer to embodiments of the invention that may provide certain benefits under certain circumstances. However, other embodiments may also be preferred under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

[0035] It should be understood that, except in any operating examples, or where otherwise indicated, all numbers expressing, for example, quantities of ingredients used in the specification and claims are to be understood as being modified in all instances by the term "about." Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and appended claims are approximations that may vary depending upon the desired properties to be obtained by the present invention.

[0036] The moisturizing agent in the embodiment of the present invention is glycerin, 1,3-butylene glycol and sodium hyaluronate in a mass ratio of 2.8:1:0.2.

[0037] The emulsifier in the embodiment of the present invention is PEG-100 stearate.

[0038] The anti-aging active ingredients in the embodiment of the present invention are resveratrol, quercetin and ergothioneine in a mass ratio of 1:1:1.

[0039] The sleep-aiding active ingredients in the embodiment of the present invention are jujube saponin, linalyl acetate and theanine in a mass ratio of 1:1:1.

[0040] The antioxidant in the embodiment of the present invention is vitamin E.

[0041] The solvent in the embodiment of the present invention is deionized water.

[0042] The chitosan in the examples of the present invention was purchased from Zhejiang Jinke Biological and has a molecular weight of about 10,000.

[0043] The hydroxypropyl chitosan in the examples of the present invention was purchased from Maclean, CAS No.: 104673-29-2.

[0044] The acetic acid concentration in the embodiment of the present invention is 1 wt%.

[0045] The preparation method of polylactic acid modified chitosan in the embodiment of the present invention comprises the following steps:

[0046] Chitosan and L-lactic acid were mixed at a mass ratio of 1:30, stirred and dissolved, and then dehydrated at 70°C under vacuum conditions for 3 h, then heated to 100°C for dehydration for 2 h, and finally heated to 120°C for dehydration for 1 h;

[0047] After cooling, stannous octoate (0.03% of the mass of L-lactic acid) was added, mixed evenly, and reacted at 130°C under vacuum conditions for 5 h. The product was washed with acetone and dried to obtain polylactic acid-modified chitosan.

[0048] The “parts” in the embodiments of the present invention refer to parts by mass.

[0049] Example 1

[0050] A skin care composition with sleep-aiding and anti-aging effects, comprising the following components in parts by weight:

[0051] 6 parts moisturizer

[0052] 1 part emulsifier

[0053] 2 parts of hydroxypropyl chitosan

[0054] 2 parts of polylactic acid modified chitosan

[0055] 1.5 parts of anti-aging active ingredients

[0056] 1.5 parts of active ingredients for sleep aid

[0057] 1.5 parts of sodium tripolyphosphate

[0058] 0.6 parts of antioxidant

[0059] 40 parts of solvent;

[0060] The preparation method of the skin care composition having sleep-aiding and anti-aging effects comprises the following steps:

[0061] S1. Add hydroxypropyl chitosan and polylactic acid-modified chitosan to 1000 parts of acetic acid according to the above-mentioned mass fractions to obtain a chitosan solution, then add the anti-aging active ingredient and the sleep-inducing active ingredient with stirring, and then add sodium tripolyphosphate. Stir and react at 30°C for 1 hour, and centrifuge and dry to obtain an intermediate product.

[0062] S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

[0063] Example 2

[0064] A skin care composition with sleep-aiding and anti-aging effects, comprising the following components in parts by weight:

[0065] 10 parts moisturizer

[0066] 1.5 parts emulsifier

[0067] 3.5 parts of hydroxypropyl chitosan

[0068] 3.5 parts of polylactic acid modified chitosan

[0069] 2.5 parts of anti-aging active ingredients

[0070] 2.2 parts of active ingredients for sleep aid

[0071] 2.4 parts of sodium tripolyphosphate

[0072] 1 part antioxidant

[0073] 65 parts of solvent;

[0074] The preparation method of the skin care composition having sleep-aiding and anti-aging effects comprises the following steps:

[0075] S1. Add hydroxypropyl chitosan and polylactic acid-modified chitosan to 1000 parts of acetic acid according to the above-mentioned mass fractions to obtain a chitosan solution, then add the anti-aging active ingredient and the sleep-inducing active ingredient with stirring, and then add sodium tripolyphosphate. Stir and react at 30°C for 1 hour, and centrifuge and dry to obtain an intermediate product.

[0076] S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

[0077] Example 3

[0078] A skin care composition with sleep-aiding and anti-aging effects, comprising the following components in parts by weight:

[0079] 14 parts moisturizer

[0080] 2.5 parts emulsifier

[0081] 5 parts of hydroxypropyl chitosan

[0082] 5 parts of polylactic acid modified chitosan

[0083] 3.5 parts of anti-aging active ingredients

[0084] 3.5 parts of active ingredients to help you sleep

[0085] 3.5 parts of sodium tripolyphosphate

[0086] 1.5 parts antioxidant

[0087] 90 parts of solvent;

[0088] The preparation method of the skin care composition having sleep-aiding and anti-aging effects comprises the following steps:

[0089] S1. Add hydroxypropyl chitosan and polylactic acid-modified chitosan to 1000 parts of acetic acid according to the above-mentioned mass fractions to obtain a chitosan solution, then add the anti-aging active ingredient and the sleep-inducing active ingredient with stirring, and then add sodium tripolyphosphate. Stir and react at 30°C for 1 hour, and centrifuge and dry to obtain an intermediate product.

[0090] S2. Mix the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stir evenly to obtain the skin care composition with sleep-aiding and anti-aging effects.

[0091] Comparative Example 1

[0092] The difference between this comparative example and Example 1 is that the polylactic acid-modified chitosan is replaced by unmodified chitosan of equal mass, and the other ingredients and preparation method are the same as those in Example 1.

[0093] Comparative Example 2

[0094] The difference between this comparative example and Example 1 is that hydroxypropyl chitosan is replaced by polylactic acid-modified chitosan of equal mass, and the other ingredients and preparation method are the same as those in Example 1.

[0095] Test Case

[0096] Fifty volunteers aged 20-30 were randomly divided into five groups of 10 each. Each group was given a sample of the composition prepared in Examples 1-3 or Comparative Examples 1-2. Each volunteer applied 5-8 g of the sample to their face before bedtime and massaged for 1 minute for 21 days.

[0097] Evaluation of sleep-aiding effect: The Pittsburgh Sleep Quality Index (PSQI) was used for scoring (the total score range is 0-21, and the higher the score, the worse the sleep quality). The difference in scores before and after the trial was calculated, and the average of each group of data was taken as the result.

[0098] Evaluation of anti-aging effects: After each group of people tried the sample for 21 days, they scored the improvement and enhancement of their skin quality on a scale of 0-10, with 10 being the highest. The result was the average of each group's data.

[0099] The samples prepared in the examples and comparative examples were sealed and stored at a constant temperature of 30° C. for 2 months, and then the above test was repeated.

[0100] The test results are shown in Table 1.

[0101] Table 1 Test results

[0102]

[0103] According to Table 1, it can be concluded that the composition prepared in the embodiment of the present invention can effectively play a role in promoting sleep and anti-aging, has a significant effect on improving sleep quality and skin quality, and can still exert a strong effect after long-term storage. However, the technical effect of Comparative Examples 1-2, which replaced hydroxypropyl chitosan or polylactic acid-modified chitosan, was significantly reduced. This is because the stability of the composition, the coating effect on the active ingredient, and the release and absorption effect of the active ingredient were all reduced. Moreover, after long-term storage, the technical effect of the comparative example further decreased, and the ideal effect of improving sleep and moisturizing the skin could not be achieved.

[0104] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the invention can be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations that come within the meaning and range of equivalents of the claims be embraced therein.

[0105] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. A skin care composition with sleep-aiding and anti-aging effects, characterized in that: The skin care composition with sleep-aiding and anti-aging effects comprises the following components in parts by mass: 3-15 parts moisturizer 1-3 parts emulsifier 3-10 parts chitosan 0.5-4 parts of anti-aging active ingredients 0.5-4 parts of sleep-aiding active ingredients 1-5 parts crosslinking agent 0.5-2 parts antioxidant 40-90 parts of solvent; Wherein, the chitosan includes hydrophilic chitosan and hydrophobic chitosan; The preparation method of the skin care composition having sleep-aiding and anti-aging effects comprises the following steps: S1. Add chitosan to acetic acid, then add the anti-aging active ingredient and the sleep-inducing active ingredient with stirring, then add a cross-linking agent, stir to react, and dry to obtain an intermediate product; S2, mixing the intermediate product, moisturizer, emulsifier, antioxidant and solvent, and stirring evenly to obtain the skin care composition with sleep-aiding and anti-aging effects; The anti-aging active ingredients include resveratrol, quercetin, and ergothioneine; the sleep-aiding active ingredients include jujube saponin, linalyl acetate, and theanine; The moisturizing agents include glycerin, butylene glycol and sodium hyaluronate; The hydrophilized chitosan is hydroxypropyl chitosan; the hydrophobized chitosan is polylactic acid modified chitosan; The mass ratio of the hydrophilized chitosan to the hydrophobized chitosan is 1:(0.1-5).

2. The skin care composition having sleep-aiding and anti-aging effects according to claim 1, characterized in that: The preparation method of the polylactic acid modified chitosan comprises the following steps: Chitosan and lactic acid are mixed, heated and dehydrated, a catalyst is added, and vacuum heating reaction is performed to obtain polylactic acid modified chitosan.

3. The skin care composition having sleep-aiding and anti-aging effects according to claim 2, characterized in that: The temperature of the heating dehydration is 70-120°C, and the temperature of the vacuum heating is 120-130°C.

4. The skin care composition having sleep-aiding and anti-aging effects according to claim 2, characterized in that: The mass ratio of the chitosan to the lactic acid is 1:(10-50).

5. The skin care composition with sleep-aiding and anti-aging effects according to claim 1, characterized in that: The temperature of the stirring reaction is 20-30°C.

6. The skin care composition with sleep-aiding and anti-aging effects according to claim 1, characterized in that: The cross-linking agent is sodium tripolyphosphate.

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