Traditional Chinese medicine composition for improving juvenile myopia as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for improving juvenile myopia and a preparation method and application thereof. The traditional Chinese medicine composition is mainly prepared from the following raw materials in parts by weight: radix astragali, semen plantaginis, semen ziziphi spinosae, semen euryales, cuttlebone, raw radix notoginseng, deer-horn glue, human placenta powder, white hyacinth beans, cortex cinnamomi, charred cortex eucommiae, fructus aurantii, water chestnut powder, fructus broussonetiae, radix morindae officinalis, semen persicae, fructus alpiniae oxyphyllae, poria with hostwood, herba agrimoniae, herba centellae, semen armeniacae amarae, herba equiseti hiemalis, gypsum rubrum, radix achyranthis bidentatae, fructus crataegi, bilberry fruit, fructus rubi, radix pseudostellariae and fructus chaenomelis. The traditional Chinese medicine is prepared from saussurea involucrata, lumbricus, mint, wormwood, radix paeoniae alba, dragon bone, oyster and uncaria. The traditional Chinese medicine composition for improving juvenile myopia provided by the invention has the effects of clearing heat and moistening dryness, tonifying qi and regulating the middle warmer, soothing liver and regulating qi, and promoting traffic and consolidating eyes through mutual cooperation and cooperation of the components, can effectively improve the vision conditions of juvenile myopia patients of different degrees, takes effect quickly, and is free of toxic and side effects. And the obvious improvement effect can be achieved after part of patients use the traditional Chinese medicine for one to three times.

Description

Technical Field

[0001] The present invention relates to the technical field of improving juvenile myopia, and in particular to a traditional Chinese medicine composition for improving juvenile myopia, and a preparation method and use thereof. Background Art

[0003] At present, surgical methods are mostly used to treat myopia, but surgery has a certain degree of risk and is limited to the treatment subjects. The treatment effect is also affected by the degree of myopia, and there is a risk of recurrence. Traditional Chinese medicine has unique advantages in improving myopia, but although there are many traditional Chinese medicine methods for myopia, there are many problems. On the one hand, some traditional Chinese medicine formulas have complex ingredients, and ordinary preparation and use methods have potential side effects, such as allergic reactions and gastrointestinal discomfort, which affect the patient's experience and confidence. On the other hand, traditional Chinese medicine is mostly taken in the form of decoctions, which is inconvenient to use, especially for children and adolescent patients, whose acceptance and compliance are poor. In addition, although some traditional Chinese medicine formulas claim to have the effect of improving myopia, the efficacy and safety of myopia patients with different degrees of mild, severe or long-term myopia still need to be improved, and it is difficult to be widely recognized. Summary of the invention

[0004] The technical problem to be solved by the present invention is the problem of poor effectiveness and safety for patients with different degrees of myopia.

[0005] In order to solve the above technical problems, the first aspect of the present invention provides a Chinese medicine composition for improving juvenile myopia, which is mainly prepared from the following raw materials in parts by weight: 5-10 parts of astragalus, 5-10 parts of plantain seeds, 15-25 parts of spiny jujube seeds, 10-20 parts of euryale seeds, 5-15 parts of sea cuttlefish, 5-10 parts of raw Panax notoginseng, 10-15 parts of antler glue, 5-15 parts of placenta powder, 10-20 parts of white hyacinth bean, 5-10 parts of cinnamon, 15-20 parts of Eucommia ulmoides carbon, 5-10 parts of Citrus aurantium, 15-20 parts of water chestnut powder, 5-10 parts of Cumulus chinensis seeds, 10-15 parts of Morinda officinalis, and 10-20 parts of peach. 5-10 parts of Rhizoma Anemarrhenae, 10-15 parts of Rhizoma Alpiniae, 5-10 parts of Rhizoma Poriae, 5-10 parts of Rhizoma Agrimoniae, 15-20 parts of Rhizoma Centellae, 5-10 parts of Rhizoma Amygdaluse, 3-10 parts of Rhizoma Equisetifolia, 10-20 parts of Rhizoma Cibotii, 5-10 parts of Rhizoma Cynoglossi, 15-20 parts of Rhizoma Glehniae, 5-10 parts of Rhizoma Cynoglossi, 10-15 parts of Rhizoma Pseudostellariae, 5-10 parts of Rhizoma Cibotii, 5-10 parts of Rhizoma Cynoglossi, 10-15 parts of Rhizoma Papaya, 5-10 parts of Rhizoma Saussureae, 10-15 parts of Rhizoma Dioscoreae, 5-10 parts of Pheretima, 5-10 parts of Phellodendron, 5-10 parts of Mint, 5-10 parts of Artemisia annua, 15-20 parts of White Peony Root, 5-10 parts of Dragon Bone, 10-20 parts of Oyster, and 5-10 parts of Uncaria Rhynchophylla.

[0006] Furthermore, the Chinese medicine composition for improving juvenile myopia is mainly prepared from the following raw materials in parts by weight: 6 parts of astragalus, 6 parts of plantain seeds, 20 parts of spiny jujube seeds, 15 parts of Euryale ferox, 10 parts of sea cuttlebone, 8 parts of raw Panax notoginseng, 13 parts of antler glue, 10 parts of placenta powder, 15 parts of white hyacinth bean, 8 parts of cinnamon, 18 parts of Eucommia ulmoides carbon, 6 parts of Citrus aurantium, 16 parts of water chestnut powder, 8 parts of Cumulus chinensis seeds, 12 parts of Morinda officinalis 8 parts, peach kernel, 12 parts, Alpinia oxyphylla, 6 parts, Poria, 8 parts, Herba Agrimoniae, 16 parts, Centella asiatica, 8 parts, Apricot kernel, 5 parts, Equisetum arvense, 15 parts, Achyranthes bidentata, 8 parts, Fructus luminescentis, 18 parts, Vaccinium myrtles, 16 parts, Raspberry, 7 parts, Pseudostellariae pseudoginseng, 14 parts, Chaenomeles sinensis, 9 parts, Saussurea involucrata, 11 parts, Peppermint, 7 parts, Artemisia argyi, 16 parts, White Peony Root, 8 parts, Os Dracaenae, 16 parts, Oyster, 7 parts, Uncaria rhynchophylla.

[0007] The components of the Chinese medicine composition of the present invention cooperate with each other and work synergistically to achieve the effects of clearing away heat and moistening dryness, invigorating qi and harmonizing the middle, soothing the liver and regulating qi, and strengthening the eyes. The Chinese medicine composition for improving juvenile myopia of the present invention has a rigorous formula, and the formula is explained as follows:

[0008] Scutellaria baicalensis is bitter and cold in nature, and enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. This prescription takes the bitter and cold nature of Scutellaria baicalensis to clear away heat and dampness, purge fire and detoxify, and is especially good at clearing away the fire in the upper part of the body, and can also cool blood and stop bleeding, improve eyesight and remove cataracts. The Compendium of Materia Medica says that it "treats headaches caused by wind-heat, dampness and heat, and red and swollen eyes." Therefore, Scutellaria baicalensis is a good product for clearing heat and improving eyesight in ophthalmology.

[0009] Plantago seed is sweet and cold in nature, and enters the kidney and bladder meridians. It has significant effects in clearing away heat, promoting diuresis, dispelling dampness and stopping diarrhea, improving eyesight and removing phlegm. The Materia Medica states that it "can relieve bladder dampness and heat, promote urination, and improve eyesight." Plantago seed can both clear away heat and improve eyesight, and is actually a commonly used medicine in ophthalmology.

[0010] Ziziphus jujuba seeds are sweet, sour, and neutral in nature. They enter the heart, liver, and gallbladder meridians. Ziziphus jujuba seeds are used in this recipe to nourish the heart and liver, calm the mind, and promote sweating and fluid production. The Compendium of Materia Medica states that "when cooked, they can treat symptoms of gallbladder deficiency, insomnia, thirst, and sweating." Although they do not directly improve eyesight, calming the mind helps the eyes rest and indirectly promotes vision recovery.

[0011] Gorgon fruit is sweet, astringent, and flat in nature. It enters the spleen and kidney meridians. Gorgon fruit can strengthen the spleen and stop diarrhea, consolidate the kidney and astringe the essence. It has a strong effect of strengthening the kidney and consolidating the essence, which helps to improve blurred vision caused by kidney deficiency.

[0012] Cuttlebone is salty, astringent, warm in nature and enters the liver and kidney meridians. It has good effects of astringing and stopping bleeding, astringing semen and stopping leukorrhea, relieving acid and relieving pain, and astringing moisture and healing sores. In ophthalmology, the astringent effect of cuttlebone can help reduce eye inflammation and promote healing.

[0013] Raw Panax notoginseng is sweet, slightly bitter, warm, and enters the liver and stomach meridians. Panax notoginseng can dissipate blood stasis and stop bleeding, reduce swelling and relieve pain, and can also promote blood circulation and remove blood stasis, improve eye blood circulation, and promote vision recovery.

[0014] Deer antler glue is sweet, salty, warm, and enters the liver and kidney meridians. It can nourish kidney yang, improve blood essence, strengthen tendons and bones, and treat vision loss caused by kidney deficiency. It is a good medicine for kidney nourishment and eyesight improvement in ophthalmology.

[0015] Placenta powder is sweet, salty, warm in nature, and enters the heart, lung, and kidney meridians. It replenishes qi and blood, warms the kidneys and improves the blurred vision caused by insufficient qi and blood and kidney deficiency.

[0016] White lentil is sweet and slightly warm in nature, and enters the spleen and stomach meridians. White lentil strengthens the spleen and eliminates dampness, harmonizes the middle and relieves heat. Although it does not directly improve eyesight, strengthening the spleen helps with nutrient absorption and supports eye health.

[0017] Cinnamon is pungent, sweet, and very hot in nature. It enters the kidney, spleen, heart, and liver meridians. Cinnamon replenishes fire and yang, dispels cold and relieves pain, warms the meridians, and guides fire back to the origin. It can improve poor blood circulation in the eyes caused by yang deficiency.

[0018] Eucommia ulmoides charcoal is sweet and warm in nature, and enters the liver and kidney meridians. It nourishes the kidneys and strengthens the tendons, stabilizes pregnancy and stops bleeding. Its kidney-tonifying power helps improve blurred vision caused by kidney deficiency.

[0019] Citrus aurantium is bitter, pungent, sour, warm, and enters the spleen and stomach meridians. Citrus aurantium regulates qi and relieves fullness, relieves stagnation and relieves swelling. Although it does not directly improve eyesight, regulating qi helps the circulation of qi and blood throughout the body and indirectly supports eye health.

[0020] Water chestnut powder is sweet and cold in nature, and enters the lung and stomach meridians. It can clear away heat, promote the production of body fluid, resolve phlegm and eliminate stagnation. Its ability to clear heat and promote the production of body fluid can help to relieve eye inflammation.

[0021] Cuscuta australis, sweet in nature and cold in flavor, enters the liver and kidney meridians. Cuscuta australis nourishes the kidney and clears the liver, improves eyesight and promotes urination, and is good at treating blurred vision caused by liver and kidney deficiency.

[0022] Morinda officinalis is pungent, sweet, slightly warm, and enters the kidney and liver meridians. It can nourish kidney yang, strengthen tendons and bones, and eliminate rheumatism. Its ability to nourish the kidney and strengthen yang can help improve vision loss caused by kidney yang deficiency.

[0023] Peach kernel is bitter, sweet, and neutral in nature. It enters the heart, liver, and large intestine meridians. Peach kernel can promote blood circulation and remove blood stasis, moisten the intestines and relieve constipation. Its ability to promote blood circulation and remove blood stasis can improve blood circulation in the eyes and promote vision recovery.

[0024] Alpinia oxyphylla is pungent in nature and warm in flavor, and enters the spleen and kidney meridians. Alpinia oxyphylla warms the spleen and stops diarrhea, warms the kidney and consolidates essence and reduces urine, and can also improve intelligence and calm the mind. It has no direct effect on vision, but it helps to improve eye fatigue caused by restlessness.

[0025] Fushen is sweet, light and flat in nature and enters the heart and spleen meridians. Fushen calms the mind and soothes the nerves, promotes diuresis and eliminates dampness. Its calming and stabilizing power helps the eyes rest and recover.

[0026] Herba Agrimoniae is bitter, astringent, and flat in nature and flavor, and enters the heart and liver meridians. Herba Agrimoniae has the functions of astringent and hemostatic, stopping malaria and stopping dysentery, detoxifying and replenishing deficiency, and its astringent and hemostatic power is helpful to improve eye hemorrhagic diseases.

[0027] Centella asiatica is bitter, pungent and cold in nature, and enters the liver, spleen and kidney meridians. Centella asiatica can clear away heat and detoxify, and relieve dampness and swelling. Its heat-clearing and detoxifying power helps to relieve eye inflammation.

[0028] Almonds are bitter, slightly warm, slightly toxic, and enter the lung and large intestine meridians. Almonds can relieve cough and asthma, moisten the intestines and promote bowel movements. Their ability to moisten the lungs can help improve dry eyes caused by dry lungs.

[0029] Equisetum arvense is sweet, bitter, and neutral in nature. It enters the lung and liver meridians. It dispels wind-heat, improves eyesight, and is good at treating wind-heat red eyes, blurred vision, and excessive tears. It is an important medicine for improving eyesight in ophthalmology.

[0030] Hanshui stone is pungent, salty and cold in nature, and enters the heart, stomach and kidney meridians. Hanshui stone clears away heat and purges fire, benefits the orifices and reduces swelling. Its ability to clear heat and purge fire helps to relieve eye inflammation.

[0031] Achyranthes bidentata is bitter, sweet, sour, and flat in nature. It enters the liver and kidney meridians. Achyranthes bidentata can remove blood stasis, tonify the liver and kidney, strengthen tendons and bones, promote diuresis and relieve stranguria, and guide blood downward. Its ability to tonify the kidney and strengthen tendons can help improve vision loss caused by liver and kidney deficiency.

[0032] Guangmingzi, sweet in nature and cold in flavor, enters the liver meridian. Guangmingzi clears the liver and improves eyesight, dispels wind and dissipates heat, is good at treating liver heat, red eyes, blurred vision, and is a good medicine for eye diseases.

[0033] Bilberry fruit is sour, sweet, and neutral in nature, and enters the lung and stomach meridians. Bilberry fruit replenishes qi and strengthens the spleen, helps digestion and stops diarrhea, improves eyesight and calms the mind. Its power to improve eyesight is good for treating blurred vision.

[0034] Raspberry, sweet, sour, warm, enters the liver, kidney, and bladder meridians. Raspberry nourishes the kidney, consolidates essence, reduces urine, nourishes the liver, improves eyesight, and is good at treating liver and kidney deficiency and blurred vision.

[0035] Radix Pseudostellariae is sweet, slightly bitter, and neutral in nature. It enters the spleen and lung meridians. Radix Pseudostellariae replenishes qi and produces body fluid. Although it does not directly improve eyesight, it helps to nourish and moisturize the eyes.

[0036] Papaya is sour and warm in nature, and enters the liver and spleen meridians. Papaya can relax muscles and activate collaterals, harmonize the stomach and eliminate dampness. Its ability to relax muscles and activate collaterals can help improve eye muscle tension.

[0037] Snow lotus is bitter, pungent, warm in nature and enters the liver, spleen and kidney meridians. Snow lotus warms the kidney and assists yang, dispels wind and dampness, promotes menstruation and activates blood circulation. Its ability to warm the kidney and assist yang helps improve vision loss caused by kidney yang deficiency and blood stasis.

[0038] Earthworms are salty and cold in nature, and enter the liver, spleen, and bladder meridians. Earthworms can clear away heat and calm the liver, extinguish wind and stop spasms, dredge meridians and relieve asthma, and promote urination. Their ability to dredge meridians can help improve blood circulation in the eyes.

[0039] Mint is pungent and cool in nature, and enters the lung and liver meridians. It can dispel wind-heat, clear the head and eyes, relieve sore throat and rash, soothe the liver and promote qi circulation. Its ability to clear the head and eyes can help relieve eye fatigue and dryness.

[0040] Mugwort is pungent, bitter, warm, slightly toxic, and enters the liver, spleen, and kidney meridians. It warms the meridians and stops bleeding, dispels cold and relieves pain, regulates menstruation and stabilizes pregnancy, and can be used externally to dispel dampness and relieve itching. Its ability to warm the meridians and dispel cold has a certain effect on improving cold and blood stasis in the eyes.

[0041] White peony root is bitter, sour, slightly cold, and enters the liver and spleen meridians. It nourishes blood and regulates menstruation, restrains yin and stops sweating, softens the liver and relieves pain, and suppresses liver yang. Its ability to nourish blood and soften the liver helps improve blurred vision caused by insufficient liver blood.

[0042] Dragon bone is sweet, astringent, and neutral in nature. It enters the heart, liver, kidney, and large intestine meridians. Dragon bone calms the mind and soothes the nerves, soothes the liver and suppresses yang, and consolidates and astringes. Its calming power helps the eyes rest and recover.

[0043] Oysters are salty and slightly cold in nature, and enter the liver, gallbladder, and kidney meridians. Oysters can calm the mind, subdue yang and replenish yin, soften and disperse nodules, and astringe. Their ability to subdue yang and replenish yin can help improve eye discomfort caused by yin deficiency and yang hyperactivity.

[0044] Uncaria rhynchophylla is sweet and cool in nature and enters the liver and pericardium meridians. Uncaria rhynchophylla can clear away heat and soothe the liver, extinguish wind and stop spasms. Its ability to clear heat and soothe the liver can help relieve eye pain or discomfort caused by liver heat.

[0045] In order to further enhance the improvement effect of the present invention, appropriate amounts of auxiliary ingredients may be added, including natural plant extracts or natural minerals.

[0046] Through the synergistic effect of the above-mentioned components, the Chinese medicine composition provided by the present invention can effectively improve the vision of adolescent myopia patients of varying degrees, while avoiding adverse reactions such as gastrointestinal discomfort and allergies.

[0047] The second aspect of the present invention provides a method for preparing the above-mentioned Chinese medicine composition for improving juvenile myopia, the preparation method comprising the following steps:

[0048] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, antler glue, Placenta powder, Lablab cylindrica, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, Water chestnut powder, Cumulus chufa seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata are respectively ground into powders, and the powders are respectively extracted by supercritical fluid to obtain extracts of each component;

[0049] (2) drying and crushing chrysanthemum seeds, blueberry fruit, raspberry, Pseudostellaria heterophylla, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster, and using an alcohol precipitation method to obtain extracts of each component;

[0050] (3) drying the Uncaria rhynchophylla and crushing it into Uncaria rhynchophylla powder;

[0051] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with the Uncaria rhynchophylla powder to prepare the Chinese medicine composition for improving juvenile myopia.

[0052] Furthermore, the preparation method of the Chinese medicine composition for improving juvenile myopia comprises the following steps:

[0053] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, Deer antler glue, Placenta powder, White hyacinth bean, Cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, Water chestnut powder, Cumulus mulberry seed, Morinda officinalis, Peach kernel, Alpinia oxyphylla, Poria, Agrimoniae scabra, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata were pulverized at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 min, and then pulverized into 300-mesh powders. Each powder was mixed with supercritical CO 2 Fluid contact to perform extraction;

[0054] The extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, placenta powder, white dung bean, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively;

[0055] (2) After microwave drying, the seeds of Guangmingzi, blueberry, raspberry, Pseudostellaria heterophylla, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster are crushed into 50 mesh coarse powder, boiled with water, cooled to 80-90° C., added with ethanol solution, and allowed to stand for 60-90 minutes, and filtered to obtain extracts of each component;

[0056] (3) drying the Uncaria rhynchophylla at 40-50° C. and crushing the Uncaria rhynchophylla into Uncaria rhynchophylla powder;

[0057] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with Uncaria rhynchophylla powder to prepare a Chinese medicine composition.

[0058] Furthermore, the components in step (2) are decocted in stages: the decocting time of dragon bone and oyster is 60 minutes, the decocting time of white peony root, pseudoginseng and papaya is 30 minutes, the decocting time of bright red seed, blueberry and raspberry is 15 minutes, and the decocting time of mint, wormwood, earthworm and snow lotus is 5 minutes.

[0059] Furthermore, supercritical CO 2The temperature of fluid extraction is 35-45°C and the pressure is 20-30MPa.

[0060] Furthermore, the temperature of ethanol precipitation extraction is 80-90° C., and the mass concentration of ethanol is 60-70%.

[0061] The third part of the present invention provides the use of the above-mentioned Chinese medicine composition for improving juvenile myopia, which is used to prepare an external dosage form for improving juvenile myopia.

[0062] Furthermore, the external dosage form is an external application patch.

[0063] 1. The Chinese medicine composition for improving juvenile myopia provided by the present invention has the effects of clearing away heat and moistening dryness, invigorating qi and harmonizing the middle, soothing the liver and regulating qi, and promoting communication and strengthening the eyes through the mutual cooperation and synergy between the components. It can effectively improve the vision of juvenile myopia patients of different degrees with rapid effect. Some patients can see obvious improvement after using it once to three times.

[0064] 2. This application is particularly aimed at one of the causes of myopia - long-distance focusing dysfunction, and uniquely adds Alpinia oxyphylla, dragon bone, placenta powder and Saussurea involucrata to the prescription. Placenta powder replenishes qi and blood, Saussurea involucrata promotes blood circulation, helps blood circulation in the eyes, and improves blurred vision caused by blood stasis; Alpinia oxyphylla and dragon bone have the effects of improving intelligence and calming the mind, which can improve eye fatigue caused by restlessness, relax eye muscles, help the eyes rest, and help restore the long-distance focusing function of myopic patients' eyes, thereby improving myopia.

[0065] This application promotes blood circulation in the eyes, improves eye fatigue, relaxes the eye muscles, and helps restore the long-distance focusing function of the eyes of myopic patients, thereby improving myopia.

[0066] 3. The Chinese medicine composition for improving juvenile myopia provided by the present invention is prepared by selecting a more effective extraction method according to the characteristics of different components, using CO 2 Superfluid extraction, the extraction process is gentle and efficient, which helps to retain the active ingredients in the components, improve the extraction rate of effective ingredients, thereby improving the bioavailability of medicinal materials, and can eliminate impurities, improve efficacy, and reduce adverse reactions; during the decoction process, the present application adopts a segmented decoction method according to the differences in drug resistance of different medicinal materials to avoid long-term high-temperature boiling that may cause damage to some effective ingredients; at the same time, the alcohol precipitation method is highly safe and can effectively remove impurities. At the same time, it can reduce microbial contamination in the extract, prevent the effective ingredients from being enzymatically hydrolyzed or oxidized, improve the extraction rate of effective ingredients, eliminate impurities, and improve efficacy. Ethanol can be efficiently recovered by normal pressure or reduced pressure distillation, reducing extraction costs.

[0067] 4. The use of the traditional Chinese medicine composition for improving juvenile myopia provided by the present invention is to prepare the traditional Chinese medicine composition into an external dressing, which is convenient to use and avoids adverse reactions such as gastrointestinal discomfort caused by decoctions. It is convenient to use and is safe and efficient. DETAILED DESCRIPTION

[0068] The technical solution of the present invention will be clearly and completely described below in conjunction with specific implementation methods. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0069] The drugs used in the present invention are all commercially available medicinal materials.

[0070] The specific examples of the Chinese medicine composition for improving juvenile myopia provided by the present invention are as follows:

[0071] Example 1

[0072] The present embodiment provides a Chinese medicine composition for improving juvenile myopia, which is mainly prepared from the following raw materials: 6g of Astragalus, 6g of Plantago, 20g of Ziziphus jujuba seeds, 15g of Euryale, 10g of Cuttlebone, 8g of Raw Panax notoginseng, 13g of Deer Horn Glue, 10g of Placenta Powder, 15g of White Laba Bean, 8g of Cinnamon Bark, 18g of Eucommia Carbon, 6g of Citrus Aurantii Immaturus, 16g of Water Chestnut Powder, 8g of Custard Fruit, 12g of Morinda Officinalis g, peach kernel 8g, yizhiren 12g, poria 6g, agrimony 8g, centella asiatica 16g, apricot kernel 8g, equisetum 5g, hanshuishi 15g, cyperus 8g, guangmingzi 18g, bilberry 8g, raspberry 16g, pseudoginseng 7g, papaya 14g, snow lotus 9g, earthworm 11g, mint 9g, wormwood 7g, white peony 16g, dragon bone 8g, oyster 16g, Uncaria 7g;

[0073] The preparation method of the above-mentioned Chinese medicine composition for improving juvenile myopia comprises the following steps:

[0074] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, Deer antler glue, Placenta powder, White hyacinth bean, Cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, Water chestnut powder, Cumulus mulberry seed, Morinda officinalis, Peach kernel, Alpinia oxyphylla, Poria, Agrimoniae scabra, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata were pulverized at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 min, and then pulverized into 300-mesh powders. Each powder was mixed with supercritical CO 2 Fluid contact, extraction is carried out at a temperature of 40°C and a pressure of 25 MPa;

[0075] The extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, placenta powder, white dung bean, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively;

[0076] (2) After microwave drying, radix leucoderma, bilberry, raspberry, radix pseudoginseng, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster are crushed into 50 mesh coarse powder respectively, and decocted with water. The decocting time of dragon bone and oyster is 60 minutes, the decocting time of white peony root, radix pseudoginseng, and papaya is 30 minutes, the decocting time of radix leucoderma, bilberry, and raspberry is 15 minutes, and the decocting time of mint, wormwood, earthworm, and snow lotus is 5 minutes. The mixture is cooled to 85°C, an ethanol solution with a mass concentration of 65% is added, and the mixture is allowed to stand for 75 minutes. The extracts of the respective components are filtered;

[0077] (3) drying the Uncaria rhynchophylla at 45° C. and crushing the Uncaria rhynchophylla into Uncaria rhynchophylla powder;

[0078] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with Uncaria rhynchophylla powder to prepare a Chinese medicine composition.

[0079] Example 2

[0080] The present embodiment provides a Chinese medicine composition for improving juvenile myopia, which is mainly prepared from the following raw materials: 5g of Astragalus, 10g of Plantago, 15g of Ziziphus jujuba seeds, 20g of Euryale, 5g of Cuttlebone, 10g of Raw Panax notoginseng, 10g of Deer Horn Glue, 15g of Placenta Powder, 10g of White Laba Bean, 10g of Cinnamon Bark, 15g of Eucommia Carbon, 10g of Citrus Aurantium, 15g of Water Chestnut Powder, 10g of Custard Fruit, 10g of Morinda Officinalis, Peach kernel 10g, Alpinia oxyphylla 10g, Poria 10g, Agrimonia 5g, Centella asiatica 20g, Apricot kernel 5g, Equisetum equisetum 10g, Cold water stone 10g, Achyranthes bidentata 10g, Guangmingzi 15g, Blueberry 10g, Raspberry 15g, Pseudostellaria 10g, Papaya 10g, Snow lotus 10g, Earthworm 10g, Mint 10g, Artemisia argyi 5g, White peony root 20g, Dragon bone 5g, Oyster 20g, Uncaria rhynchophylla 5g;

[0081] The preparation method of the above-mentioned Chinese medicine composition for improving juvenile myopia comprises the following steps:

[0082] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, Deer antler glue, Placenta powder, White hyacinth bean, Cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, Water chestnut powder, Cumulus mulberry seed, Morinda officinalis, Peach kernel, Alpinia oxyphylla, Poria, Agrimoniae scabra, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata were pulverized at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 min, and then pulverized into 300-mesh powders. Each powder was mixed with supercritical CO 2Fluid contact, extraction was carried out at a temperature of 35°C and a pressure of 30 MPa;

[0083] The extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, placenta powder, white dung bean, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively;

[0084] (2) After microwave drying, the seeds of Guangmingzi, blueberry, raspberry, Pseudostellaria baicalensis, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster were crushed into 50 mesh coarse powder, and decocted with water. The decocting time of dragon bone and oyster was 60 minutes, the decocting time of white peony root, Pseudostellaria baicalensis, and papaya was 30 minutes, the decocting time of Guangmingzi, blueberry, and raspberry was 15 minutes, and the decocting time of mint, wormwood, earthworm, and snow lotus was 5 minutes. After cooling to 80°C, a 70% ethanol solution was added and allowed to stand for 60 minutes, and the extracts of the respective components were obtained by filtration;

[0085] (3) drying the Uncaria rhynchophylla at 40° C. and crushing the Uncaria rhynchophylla into Uncaria rhynchophylla powder;

[0086] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with Uncaria rhynchophylla powder to prepare a Chinese medicine composition.

[0087] Example 3

[0088] The present embodiment provides a Chinese medicine composition for improving juvenile myopia, which is mainly prepared from the following raw materials: 10g of Astragalus, 5g of Plantago, 25g of Ziziphus jujuba seeds, 10g of Euryale, 15g of Cuttlebone, 5g of Raw Panax notoginseng, 15g of Deer Horn Glue, 5g of Placenta Powder, 20g of White Laba Bean, 5g of Cinnamon, 20g of Eucommia Carbon, 5g of Citrus Aurantium, 20g of Water Chestnut Powder, 5g of Cumulus Cuscuta, 15g of Morinda Officinalis, Peach kernel 5g, Alpinia oxyphylla 15g, Poria 5g, Herba Agrimoniae 10g, Centella asiatica 15g, Apricot kernel 10g, Equisetum equisetum 3g, Hanshui stone 20g, Achyranthes bidentata 5g, Guangmingzi 20g, Vaccinium 5g, Raspberry 20g, Pseudostellaria 5g, Papaya 15g, Saussurea involucrata 5g, Pheretima chinensis 15g, Earthworm 15g, Mint 5g, Mugwort 10g, White Peony 15g, Dragon Bone 10g, Oyster 10g, Uncaria rhynchophylla 10g.

[0089] The preparation method of the above-mentioned Chinese medicine composition for improving juvenile myopia comprises the following steps:

[0090] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, Deer antler glue, Placenta powder, White hyacinth bean, Cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, Water chestnut powder, Cumulus mulberry seed, Morinda officinalis, Peach kernel, Alpinia oxyphylla, Poria, Agrimoniae scabra, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata were pulverized at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 min, and then pulverized into 300-mesh powders. Each powder was mixed with supercritical CO 2 Fluid contact, extraction is carried out at a temperature of 45°C and a pressure of 20 MPa;

[0091] The extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, placenta powder, white dung bean, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively;

[0092] (2) After microwave drying, the seeds of Guangmingzi, blueberry, raspberry, Pseudostellaria chinensis, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster are crushed into 50 mesh coarse powder, and water is added for decoction. The decoction time of dragon bone and oyster is 60 minutes, the decoction time of white peony root, Pseudostellaria chinensis, and papaya is 30 minutes, the decoction time of Guangmingzi, blueberry, and raspberry is 15 minutes, and the decoction time of mint, wormwood, earthworm, and snow lotus is 5 minutes. After cooling to 90° C., a 60% ethanol solution is added and allowed to stand for 90 minutes, and the extracts of the respective components are obtained by filtration;

[0093] (3) drying the Uncaria rhynchophylla at 50° C. and crushing the Uncaria rhynchophylla into Uncaria rhynchophylla powder;

[0094] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with Uncaria rhynchophylla powder to prepare a Chinese medicine composition.

[0095] Example 4

[0096] The present embodiment provides a Chinese medicine composition for improving juvenile myopia, which is mainly prepared from the following raw materials: 8g of Astragalus, 9g of Plantago, 18g of Ziziphus jujuba seeds, 13g of Euryale ferox, 12g of Cuttlebone, 7g of Raw Panax notoginseng, 12g of Deer Horn Glue, 13g of Placenta Powder, 14g of White Laba, 6g of Cinnamon Bark, 19g of Eucommia Carbon, 7g of Citrus Aurantium, 19g of Water Chestnut Powder, 6g of Cumulus Cuscuta Australis, 11g of Morinda Officinalis g, peach kernel 6g, Alpinia oxyphylla 14g, Poria 9g, Herba Agrimoniae 6g, Centella asiatica 19g, Apricot kernel 6g, Equisetum equisetum 6g, Cold Water Stone 18g, Achyranthes bidentata 7g, Guangmingzi 16g, Blueberry 9g, Rubus idaeus 17g, Pseudostellariae Pseudostellariae 9g, Papaya 11g, Saussurea involucrata 8g, Pheretima lumbarum 12g, Mint 8g, Mugwort 6g, White Peony 18g, Dragon Bone 6g, Oyster 13g, Uncaria rhynchophylla 8g.

[0097] The preparation method of the above-mentioned Chinese medicine composition for improving juvenile myopia comprises the following steps:

[0098] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, Deer antler glue, Placenta powder, White hyacinth bean, Cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, Water chestnut powder, Cumulus mulberry seed, Morinda officinalis, Peach kernel, Alpinia oxyphylla, Poria, Agrimoniae scabra, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata were pulverized at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 min, and then pulverized into 300-mesh powders. Each powder was mixed with supercritical CO 2 Fluid contact, extraction was carried out at a temperature of 38°C and a pressure of 28 MPa;

[0099] The extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, placenta powder, white dung bean, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively;

[0100] (2) After microwave drying, the seeds of Guangmingzi, blueberry, raspberry, Radix Pseudostellariae, papaya, Saussurea involucrata, earthworm, mint, wormwood, white peony root, dragon bone, and oyster are crushed into 50 mesh coarse powder, and water is added for decoction. The decoction time of dragon bone and oyster is 60 minutes, the decoction time of white peony root, Radix Pseudostellariae, and papaya is 30 minutes, the decoction time of Guangmingzi, blueberry, and raspberry is 15 minutes, and the decoction time of mint, wormwood, earthworm, and Saussurea involucrata is 5 minutes. The mixture is cooled to 85° C., an ethanol solution with a mass concentration of 65% is added, and the mixture is allowed to stand for 75 minutes. After the mixture is cooled to 88° C., an ethanol solution with a mass concentration of 68% is added, and the mixture is allowed to stand for 80 minutes to obtain extracts of the respective components.

[0101] (3) drying the Uncaria rhynchophylla at 48° C. and crushing the Uncaria rhynchophylla into Uncaria rhynchophylla powder;

[0102] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with Uncaria rhynchophylla powder to prepare a Chinese medicine composition.

[0103] Example 5

[0104] The present embodiment provides a Chinese medicine composition for improving juvenile myopia, which is mainly prepared from the following raw materials: 9g of Astragalus, 7g of Plantago, 23g of Ziziphus jujuba seeds, 18g of Euryale, 8g of Cuttlebone, 9g of Raw Panax notoginseng, 14g of Deer Horn Glue, 7g of Placenta Powder, 17g of White Laba Bean, 7g of Cinnamon Bark, 16g of Eucommia Carbon, 8g of Citrus Aurantium, 18g of Water Chestnut Powder, 7g of Custard Fruit, 14g of Morinda Officinalis , peach kernel 9g, Alpinia oxyphylla 13g, Poria 7g, Agrimony vine 7g, Centella asiatica 18g, Apricot kernel 7g, Equisetum equisetum 8g, Hanshui stone 13g, Achyranthes bidentata 9g, Guangmingzi 17g, Vaccinium myrtles 6g, Rubus idaeus 19g, Pseudostellaria 6g, Papaya 13g, Saussurea involucrata 6g, Pheretima ternata 14g, Mint 6g, Mugwort 8g, White Peony 17g, Dragon Bone 9g, Oyster 18g, Uncaria rhynchophylla 6g.

[0105] The preparation method of the above-mentioned Chinese medicine composition for improving juvenile myopia comprises the following steps:

[0106] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, Deer antler glue, Placenta powder, White hyacinth bean, Cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, Water chestnut powder, Cumulus mulberry seed, Morinda officinalis, Peach kernel, Alpinia oxyphylla, Poria, Agrimoniae scabra, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata were pulverized at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 min, and pulverized into 300-mesh powders. Each powder was mixed with supercritical CO 2 Fluid contact, extraction was carried out at a temperature of 42°C and a pressure of 26 MPa;

[0107] The extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, placenta powder, white dung bean, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively;

[0108] (2) After microwave drying, the seeds of Guangmingzi, blueberry, raspberry, Pseudostellaria baicalensis, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster were crushed into 50 mesh coarse powder, and decocted with water. The decocting time of dragon bone and oyster was 60 minutes, the decocting time of white peony root, Pseudostellaria baicalensis, and papaya was 30 minutes, the decocting time of Guangmingzi, blueberry, and raspberry was 15 minutes, and the decocting time of mint, wormwood, earthworm, and snow lotus was 5 minutes. After cooling to 82°C, a 62% ethanol solution was added and allowed to stand for 70 minutes to obtain the extracts of the respective components;

[0109] (3) drying the Uncaria rhynchophylla at 42° C. and crushing the Uncaria rhynchophylla into Uncaria rhynchophylla powder;

[0110] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with Uncaria rhynchophylla powder to prepare a Chinese medicine composition.

[0111] Example 6

[0112] 20 g of the Chinese medicinal composition for improving juvenile myopia prepared in Example 1 was taken to prepare an external application patch.

[0113] Example 7

[0114] Take 20g of the Chinese medicinal composition for improving juvenile myopia prepared in Example 2 to prepare an external application patch.

[0115] Example 8

[0116] Take 20g of the Chinese medicinal composition for improving juvenile myopia prepared in Example 3 to prepare an external application patch.

[0117] Example 9

[0118] Take 20g of the Chinese medicinal composition for improving juvenile myopia prepared in Example 4 to prepare an external application patch.

[0119] Example 10

[0120] Take 20 g of the Chinese medicinal composition for improving juvenile myopia prepared in Example 5 to prepare an external application patch.

[0121] Comparative Example 1

[0122] The present embodiment provides a Chinese medicine composition for improving juvenile myopia, which is mainly prepared from the following raw materials: 6g of Astragalus, 6g of Plantago, 20g of Ziziphus jujuba seeds, 15g of Euryale, 10g of Cuttlebone, 8g of Raw Panax notoginseng, 13g of Deer Horn Glue, 15g of White Lablab, 8g of Cinnamon, 18g of Eucommia Carbon, 6g of Citrus Aurantium, 16g of Water Chestnut Powder, 8g of Cumulus mulberry seeds, 12g of Morinda officinalis, 8g of Peach Kernel, 6g of Poria, 8g of Agrimoniae, 16g of Centella asiatica, 8g of Apricot, 5g of Equisetum, 15g of Cold Water Stone, 8g of Cyathula, 18g of Bright Star Seed, 8g of Blueberry Fruit, 16g of Rubus idaeus, 7g of Pseudostellariae Pseudostellariae, 14g of Papaya, 11g of Pheretima, 9g of Mentha, 7g of Artemisia argyi, 16g of White Peony Root, 16g of Oyster, and 7g of Uncaria rhynchophylla.

[0123] The preparation method of the above-mentioned Chinese medicine composition for improving juvenile myopia comprises the following steps:

[0124] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, antler glue, white hyacinth bean, cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, water chestnut powder, Cumulus mulberry seed, Morinda officinalis, peach kernel, Poria, Agrimonia, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were pulverized at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 min, and then pulverized into 300-mesh powders. Each powder was mixed with supercritical CO 2 Fluid contact, extraction is carried out at a temperature of 40°C and a pressure of 25 MPa;

[0125] Extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, white hyacinth bean, cinnamon bark, Eucommia ulmoides carbon, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Poria, Agrimonia, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively;

[0126] (2) After microwave drying, the seeds of Guangmingzi, blueberry, raspberry, Radix Pseudostellariae, papaya, earthworm, mint, wormwood, white peony root, and oyster were crushed into 50 mesh coarse powder, and decocted with water. The oyster was decocted for 60 minutes, the white peony root, Radix Pseudostellariae, and papaya were decocted for 30 minutes, the seeds of Guangmingzi, blueberry, and raspberry were decocted for 15 minutes, and the mint, wormwood, and earthworm were decocted for 5 minutes. After cooling to 85°C, a 65% ethanol solution was added and allowed to stand for 75 minutes, and the extracts of the respective components were obtained by filtration;

[0127] (3) drying the Uncaria rhynchophylla at 45° C. and crushing the Uncaria rhynchophylla into Uncaria rhynchophylla powder;

[0128] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with Uncaria rhynchophylla powder to prepare a Chinese medicine composition.

[0129] Take 20g of the prepared Chinese medicine composition to prepare an external application patch.

[0130] Comparative Example 2

[0131] The present embodiment provides a Chinese medicine composition for improving juvenile myopia, which is mainly prepared from the following raw materials: 6g of Astragalus, 6g of Plantago, 20g of Ziziphus jujuba seeds, 15g of Euryale, 10g of Cuttlebone, 8g of Raw Panax notoginseng, 13g of Deer Horn Glue, 10g of Placenta Powder, 15g of White Laba Bean, 8g of Cinnamon Bark, 18g of Eucommia Carbon, 6g of Citrus Aurantii Immaturus, 16g of Water Chestnut Powder, 8g of Custard Fruit, 12g of Morinda Officinalis g, peach kernel 8g, yizhiren 12g, poria 6g, agrimony 8g, centella asiatica 16g, apricot kernel 8g, equisetum 5g, hanshuishi 15g, cyperus 8g, guangmingzi 18g, bilberry 8g, raspberry 16g, pseudoginseng 7g, papaya 14g, snow lotus 9g, earthworm 11g, mint 9g, wormwood 7g, white peony 16g, dragon bone 8g, oyster 16g, Uncaria 7g;

[0132] The preparation method of the above-mentioned Chinese medicine composition for improving juvenile myopia comprises the following steps:

[0133] (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, Deer antler glue, Placenta powder, White lentil, Cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, Water chestnut powder, Cumulus chufa seed, Morinda officinalis, Peach kernel, Alpinia oxyphylla, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata were ground at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 minutes, and then ground into 300-mesh powders. Each powder was decocted with water for 30 minutes, filtered, and concentrated to obtain extracts of each component;

[0134] The extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, placenta powder, white dung bean, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively;

[0135] (2) After microwave drying, radix leucoderma, bilberry, raspberry, radix pseudoginseng, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster are crushed into 50 mesh coarse powder respectively, and boiled in water. The boiling time of dragon bone and oyster is 60 minutes, the boiling time of white peony root, radix pseudoginseng, and papaya is 30 minutes, the boiling time of radix leucoderma, bilberry, and raspberry is 15 minutes, and the boiling time of mint, wormwood, earthworm, and snow lotus is 5 minutes. After filtering and concentrating, the extracts of each component are obtained;

[0136] (3) drying the Uncaria rhynchophylla at 45°C and crushing it into fine powder;

[0137] (4) The extract in step (1) and the extract in step (2) are uniformly mixed with the Uncaria rhynchophylla powder and the Uncaria rhynchophylla fine powder to prepare a Chinese medicine composition.

[0138] Take 20g of the prepared Chinese medicine composition to prepare an external application patch.

[0139] Experimental Example 1

[0140] The external patches prepared in Examples 6-10 and Comparative Examples 1-2 were applied to clinical treatment.

[0141] (1) Clinical treatment subjects

[0142] Generally, patients were from outpatient clinics and were randomly divided into treatment group and control group according to the order of patients' visits and acceptance. Male and female patients were randomly divided into two groups. The data were accumulated to symmetrical groups and then statistically analyzed. The data were statistically analyzed for 200 cases (400 eyes) in the treatment group and 200 cases (400 eyes) in the control group. The general data of the two groups of patients in terms of gender, age, and course of disease were statistically processed and were comparable. The general data of the two groups of patients are shown in Table 1.

[0143] Table 1 Patient data

[0144] type Treatment group / case Control group / cases Male patient / Female patient 51 / 49 51 / 49 Mild / Moderate / Severe 66 / 23 / 11 66 / 24 / 10 7-12 years old / 13-18 years old 57 / 43 56 / 44

[0145] (2) Clinical treatment methods

[0146] All cases were asked about their medical history in detail, and their vision was checked using a standard logarithmic visual acuity chart. After mydriasis, the optometry was in accordance with the diagnostic criteria for myopia. Their near vision was normal, and their far vision was less than 5.0, which could be corrected with a concave spherical lens. They were adolescents aged 7-18 years old, with no obvious family history of genetic diseases, and no other eye diseases or systemic diseases. Among them, a visual acuity of 4.8-5.0 was considered mild myopia, 4.5-4.7 was considered moderate myopia, and 4.0-4.4 was considered severe myopia.

[0147] The treatment was carried out with the patients' informed consent. During the treatment period, the patients in the experimental and control groups were advised to: do eye exercises, study in an environment with appropriate lighting, read and write in a correct posture, avoid excessive use of computers and mobile phones, and keep their eyes clean.

[0148] ① Treatment group

[0149] Clean the eyes with warm water before use, close the eyes and use the external application patch prepared in Example 6 of the present application, the application time is 40 minutes for mild symptoms, 50 minutes for moderate symptoms, and 60 minutes for severe symptoms, once a day. The above method is used once a day, and 21 days is a course of treatment.

[0150] ②Control group

[0151] The conventional ophthalmic treatment for juvenile myopia is 0.5% tropicamide eye drops.

[0152] Directions: Apply one drop to each eye every night before going to bed.

[0153] Treatment duration: 21 days in total.

[0154] (3) Efficacy assessment

[0155] Efficacy judgment criteria: formulated in accordance with the "Guidelines for Clinical Research of New Chinese Medicines" issued by the Ministry of Health: Cure: Clinical symptoms are completely eliminated, long-distance vision returns to normal, vision is improved to above 5.0, and emmetropia is present;

[0156] Improvement: Clinical symptoms improved significantly, and distance vision improved by >2 lines;

[0157] Ineffective: clinical symptoms improved to varying degrees, and distance vision improved by <2 lines;

[0158] Short-term effect: clinical symptoms will be significantly improved within 3 days;

[0159] Relapse rate = number of relapses after cure / number of initial cures × 100%.

[0160] (4) Treatment effect

[0161] All data were analyzed using statistical software, and the therapeutic results are shown in Table 2.

[0162] Table 2 Efficacy results

[0163]

[0164] As can be seen from Table 2, the external application prepared from the Chinese medicine composition for improving juvenile myopia provided by the present invention has a significant improvement effect on mild, moderate and severe myopia. For mild patients, it can be cured in one course of treatment (21 days), and there is obvious improvement in the short term; for moderate patients, the cure rate is as high as 95.7% in one course of treatment, and the short-term effective rate is as high as 91.3%; for severe patients, the cure rate in one course of treatment can also reach 81.8%, and there is also a short-term effective rate of 63.6% in the short term. The present invention is not only easy to use, quick to take effect, and has a low recurrence rate and lasting efficacy, but also has significant advantages for the treatment of juvenile myopia.

[0165] For patients in the control group, the treatment methods of the treatment group were used after the experiment. For patients who have improved, the treatment course was increased according to the specific improvement situation. For cured patients, follow-up was conducted for 1 to 2 years. For cases that relapsed within one year after cure, the treatment methods of the treatment group were used to cure or improve. For patients with severe disease or myopia for many years, the treatment course can be increased as consolidation treatment.

[0166] (5) Typical Cases

[0167] Case 1, Liu * Lei, male, 11 years old, fifth grade student, left eye naked eye vision <4.8, right eye naked eye vision <4.8 (mild myopia in adolescents). The external application of the present invention was used once a day for 40 minutes each time. After 7 days, the naked eye vision was restored to 5.0 using the national standard vision chart. It was continued to be used for 21 days. After one course of treatment, the naked eye vision of both eyes was restored to 5.2. After a follow-up visit 12 months later, the vision was good and there was no recurrence.

[0168] Case 2, Liao Jing, female, 14 years old, a ninth grade student in middle school, with naked eye vision of the left eye <4.6, and naked eye vision of the right eye <4.5 (belonging to the middle myopia of adolescents). The external application of the present invention was used once a day for 50 minutes each time. After 14 days, the naked eye vision was restored to 5.0 using the national standard vision chart. It was continued to be used for 21 days. After one course of treatment, the naked eye vision of both eyes was restored to 5.1. After a follow-up visit 12 months later, the vision was good and there was no recurrence.

[0169] Case 3, Zhang * Xuan, male, 17-year-old high school sophomore, left eye naked eye vision <4.5, right eye naked eye vision <4.6 (belongs to the adolescent myopia and has been suffering from it for many years). The external application of the present invention is used once a day, 50 minutes each time, and the naked eye vision is restored to 5.0 after 19 days using the national standard vision chart. Continue to use it for 21 days, and after one course of treatment, the naked eye vision of both eyes is restored to 5.0. After a follow-up visit after 12 months, the vision is good and there is no recurrence.

[0170] Case 4, Gu Han, male, 10 years old, fourth grade student, left eye naked eye vision <4.7, right eye naked eye vision <4.8 (belongs to the middle myopia of adolescents). The external application of the present invention, once a day, 50 minutes each time, after a course of treatment, the naked eye vision of both eyes was 5.3. After a follow-up visit 12 months later, the vision was good and there was no recurrence.

[0171] Case 5, Yu * ​​Xue, female, 15 years old, ninth grade student in middle school, naked eye vision of left eye <4.4, naked eye vision of right eye <4.1 (severe myopia in adolescents and a patient for many years). The topical patch of the present invention was applied once a day for 60 minutes each time, and a course of treatment was 21 days. After a course of treatment, the naked eye vision of the left eye was 5.1, and the naked eye vision of the right eye was 5.0. After a follow-up visit 12 months later, the vision was good and there was no recurrence.

[0172] Case 6, Fang Ya, female, 11 years old, fifth grade student, left eye naked eye vision <4.0, right eye naked eye vision <4.2 (severe myopia in adolescents). The external application of the present invention was used once a day, 60 minutes each time, 21 days as a course of treatment. After one course of treatment, the naked eye vision of both eyes recovered to 5.2. After a follow-up visit 12 months later, the vision was very good without recurrence.

[0173] Case 7, Mr. He, male, 13 years old, sixth grade student, left eye naked eye vision <4.6, right eye naked eye vision <4.6 (belongs to the middle myopia of adolescents). The external application of the present invention is used once a day, 50 minutes each time, 21 days as a course of treatment. After a course of treatment, the naked eye vision of both eyes recovered to 5.2. After a follow-up visit 12 months later, the vision is very good without recurrence.

[0174] Case 8, Du * Yi, female, 12 years old, fifth grade student, left eye naked eye vision <4.2, right eye naked eye vision <4.5 (severe myopia in adolescents). The external application of the present invention was used once a day, 60 minutes each time, 21 days as a course of treatment. After one course of treatment, the naked eye vision of both eyes recovered to 5.1. After a follow-up visit 12 months later, the vision was good and there was no recurrence.

[0175] Case 9, Li * Tong, female, 12-year-old fifth-grade primary school student, left eye naked eye vision <4.2, right eye naked eye vision <4.2 (severe myopia in adolescents). The external application of the present invention was used once a day, 60 minutes each time, 21 days as a course of treatment. After one course of treatment, the naked eye vision of both eyes recovered to 5.0. After a follow-up visit 12 months later, the vision was good and there was no recurrence.

[0176] Case 10, Cao*Niu, male, 11 years old, fourth grade student, left eye naked eye vision <4.1, right eye naked eye vision <4.1 (severe myopia in adolescents). The topical patch of the present invention was applied once a day for 60 minutes each time, and a course of treatment of 21 days. After one course of treatment, the naked eye vision of both eyes recovered to 5.3. After a follow-up visit 12 months later, the vision was very good without recurrence.

[0177] Case 11, He*, male, 15-year-old ninth grade student, left eye naked eye vision <4.3, right eye naked eye vision <4.3 (severe myopia in adolescents and long-term patients). The topical patch of the present invention was applied once a day for 60 minutes each time, and 21 days was a course of treatment. After a course of treatment, the naked eye vision of both eyes recovered to 5.0. After a follow-up visit 12 months later, the vision was very good and there was no recurrence.

[0178] Case 12, Zhang Fan, male, 11 years old, fifth grade student, left eye naked eye vision <4.2, right eye naked eye vision <4.3 (severe myopia in adolescents). The topical patch of the present invention was applied once a day for 60 minutes each time, and 21 days was a course of treatment. After one course of treatment, the naked eye vision of the left eye was 5.2, and the naked eye vision of the right eye was 5.1. After a follow-up visit 12 months later, the vision was good and there was no recurrence.

[0179] Case 13, Shi * Hao, male, 13 years old, sixth grade student, left eye naked eye vision <4.6, right eye naked eye vision <4.6 (belongs to the middle myopia of adolescents). The topical patch of the present invention is applied once a day, 50 minutes each time, 21 days as a course of treatment. After one course of treatment, the naked eye vision of the left eye is 5.0, and the naked eye vision of the right eye is 5.0. After a follow-up visit 12 months later, the vision is good and there is no recurrence.

[0180] It can be seen from the above typical cases that the present invention can effectively improve the myopia of adolescent myopia patients of different degrees, with rapid effect. It also has good therapeutic effect on patients with long-term myopia. Some patients can see obvious improvement in one time, and the therapeutic effect is long-lasting, stable and has a low recurrence rate.

[0181] Experimental Example 2

[0182] The external patch prepared in Example 6 and Comparative Examples 1-3 was applied to clinical treatment. 80 patients aged 13-18 years old, male and female, were selected and divided into an experimental group and a comparative group, and then statistically analyzed. All cases were asked about their medical history in detail, and their vision was checked using a standard logarithmic visual acuity chart. After mydriasis, the optometry met the myopia diagnosis criteria, the near vision was normal, the far vision was less than 5.0, and it could be corrected with a concave spherical lens. There was no obvious family history of myopia, and there were no other eye diseases and systemic diseases.

[0183] Table 3 Patient selection

[0184] type male female Example Group 20 20 Comparative Example 1 20 20 Comparative Example 2 20 20 Comparative Example 3 20 20

[0185] The clinical treatment method is as follows: the treatment is carried out with the patient's knowledge and willingness to accept the treatment. During the treatment, the patients in the experimental group and the control group are advised to: do eye exercises, study in a suitable light environment, correct reading and writing postures, avoid excessive use of computers and mobile phones, etc., and keep their eyes clean.

[0186] ① Experimental group

[0187] Clean the eyes with warm water before use, close the eyes and use the external application patch prepared in Example 6 of the present application for 50 minutes, once a day. The above method is used once a day, and 21 days is a course of treatment.

[0188] ②Comparative group

[0189] Clean the eyes with warm water before use, close the eyes and use the external application prepared in Comparative Examples 1-3 of the present application for 50 minutes, once a day. The above method is used once a day, and 21 days is a course of treatment.

[0190] The same efficacy evaluation criteria as in Experimental Example 1 were used:

[0191] Table 4 Efficacy results

[0192]

[0193] As can be seen from Table 4, the preparation method provided by the present invention selects a more effective extraction method according to the characteristics of different components, which is gentle and efficient, helps to retain the active ingredients in the components, and improves the extraction rate of the effective ingredients, thereby improving the bioavailability of the medicinal materials and improving the efficacy.

[0194] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. However, the obvious changes or modifications derived therefrom are still within the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for improving juvenile myopia, characterized in that: The Chinese medicine composition for improving juvenile myopia is mainly prepared from the following raw materials in parts by weight: 5-10 parts of astragalus, 5-10 parts of plantain seeds, 15-25 parts of spiny jujube seeds, 10-20 parts of Euryale ferox, 5-15 parts of cuttlebone, 5-10 parts of raw Panax notoginseng, 10-15 parts of antler glue, 5-15 parts of placenta powder, 10-20 parts of white hyacinth bean, 5-10 parts of cinnamon, 15-20 parts of Eucommia ulmoides carbon, 5-10 parts of Citrus aurantium, 15-20 parts of water chestnut powder, 5-10 parts of Cumulus chinensis seeds, 10-15 parts of Morinda officinalis, 5-10 parts of peach kernel, 10-20 parts of Alpinia oxyphylla 10-15 parts, 5-10 parts of Poria, 5-10 parts of Agrimonia, 15-20 parts of Centella asiatica, 5-10 parts of Apricot, 3-10 parts of Equisetum, 10-20 parts of Cold Water Stone, 5-10 parts of Achyranthes bidentata, 15-20 parts of Guangmingzi, 5-10 parts of Blueberry, 15-20 parts of Rubus idaeus, 5-10 parts of Pseudostellariae Pseudostellariae, 10-15 parts of Papaya, 5-10 parts of Saussurea involucrata, 10-15 parts of Pheretima, 5-10 parts of Mint, 5-10 parts of Artemisia annua, 15-20 parts of White Peony Root, 5-10 parts of Dragon Bone, 10-20 parts of Oyster, and 5-10 parts of Uncaria rhynchophylla.

2. The Chinese medicine composition for improving juvenile myopia according to claim 1, characterized in that: The Chinese medicine composition for improving juvenile myopia is mainly prepared from the following raw materials in parts by weight: 6 parts of astragalus, 6 parts of plantain seeds, 20 parts of spiny jujube seeds, 15 parts of Euryale ferox, 10 parts of sea cuttlebone, 8 parts of raw Panax notoginseng, 13 parts of antler glue, 10 parts of placenta powder, 15 parts of white hyacinth bean, 8 parts of cinnamon bark, 18 parts of Eucommia ulmoides carbon, 6 parts of Citrus aurantium, 16 parts of water chestnut powder, 8 parts of Cumulus chinensis seeds, 12 parts of Morinda officinalis, 8 parts of peach kernel, 12 parts of Alpinia oxyphylla, 6 parts of Poria, 8 parts of Herba Agrimoniae, 16 parts of Centella asiatica, 8 parts of Apricot kernel, 5 parts of Equisetum arvense, 15 parts of Salicornia herba, 8 parts of Cyathulae Bidentatae, 18 parts of Fructus Bryophylli, 8 parts of Vaccinium myrtles, 16 parts of Rubus idaeus, 7 parts of Radix Pseudostellariae, 14 parts of Chaenomeles sinensis, 9 parts of Saussurea involucratae, 11 parts of Pheretima, 9 parts of Menthus officinalis, 7 parts of Artemisia argyi, 16 parts of Radix Paeoniae Alba, 8 parts of Os Dracaenae, 16 parts of Os Os Ostracum, 7 parts of Oyster, and 7 parts of Uncaria rhynchophyllae.

3. A method for preparing the Chinese medicine composition for improving juvenile myopia as claimed in claim 1 or 2, characterized in that: The following steps are involved: (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, antler glue, Placenta powder, Lablab cylindrica, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, Water chestnut powder, Cumulus chufa seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata are respectively ground into powders, and the powders are respectively extracted by supercritical fluid to obtain extracts of each component; (2) drying and crushing chrysanthemum seeds, blueberry fruit, raspberry, Pseudostellaria heterophylla, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster, and using an alcohol precipitation method to obtain extracts of each component; (3) drying the Uncaria rhynchophylla and crushing it into Uncaria rhynchophylla powder; (4) The extract in step (1) and the extract in step (2) are uniformly mixed with the Uncaria rhynchophylla powder to prepare the Chinese medicine composition for improving juvenile myopia.

4. The method for preparing the Chinese medicine composition for improving juvenile myopia according to claim 3, characterized in that: The following steps are involved: (1) Scutellaria baicalensis, Plantago seed, Ziziphus jujuba seed, Euryale ferox, Cuttlebone, Panax notoginseng, Deer antler glue, Placenta powder, White hyacinth bean, Cinnamon bark, Eucommia ulmoides carbonization, Citrus aurantium, Water chestnut powder, Cumulus chufa seed, Morinda officinalis, Peach kernel, Alpinia oxyphylla, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, Achyranthes bidentata were respectively ground at 60°C, passed through a 200-mesh sieve, sterilized at 100°C for 30 min, and then ground into 300-mesh powders, and the powders were contacted with supercritical CO2 fluid for extraction; The extracts of scutellaria baicalensis, plantago seed, jujube seed, Euryale ferox, cuttlebone, raw Panax notoginseng, antler glue, placenta powder, white dung bean, cinnamon bark, Eucommia ulmoides carbonized, Citrus aurantium, water chestnut powder, Cuscuta australis seed, Morinda officinalis, peach kernel, Alpinia oxyphylla seed, Poria, Agrimoniae herb, Centella asiatica, Apricot kernel, Equisetum arvense, Cold water stone, and Achyranthes bidentata were obtained respectively; (2) After microwave drying, the seeds of Guangmingzi, blueberry, raspberry, Pseudostellaria heterophylla, papaya, snow lotus, earthworm, mint, wormwood, white peony root, dragon bone, and oyster are crushed into 50 mesh coarse powder, boiled with water, cooled to 80-90° C., added with ethanol solution, and allowed to stand for 60-90 minutes, and filtered to obtain extracts of each component; (3) drying the Uncaria rhynchophylla at 40-50° C. and crushing it into fine powder; (4) The extract in step (1) and the extract in step (2) are mixed with Uncaria rhynchophylla fine powder to prepare the Chinese medicine composition for improving juvenile myopia.

5. The method for preparing the Chinese medicine composition for improving juvenile myopia according to claim 4, characterized in that: The temperature of the supercritical CO2 fluid extraction is 35-45°C and the pressure is 20-30MPa.

6. The method for preparing the Chinese medicine composition for improving juvenile myopia according to claim 4, characterized in that: The ethanol mass concentration is 60-70%.

7. A use of the Chinese medicine composition for improving juvenile myopia as claimed in claim 1 or 2, characterized in that: The Chinese medicine composition is used for preparing an external dosage form for improving juvenile myopia.

8. The use of the Chinese medicine composition for improving juvenile myopia according to claim 7, characterized in that: The external dosage form is an external application patch.

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