Tumor electric field treatment equipment and tumor electric field treatment system

Abstract

Provided is a tumor electric field treatment device, comprising: an AC power supply module configured to output an alternating electric signal; the adjustable filter is electrically connected to the alternating current power supply module so as to output a filtered alternating electric signal; and the controller is configured to control the frequency of the alternating electric signal output by the alternating current power supply module and at least adjust the cut-off frequency of the adjustable filter in response to the frequency change of the alternating electric signal.

Description

Technical Field

[0001] The present disclosure relates to a tumor electric field treatment device and a tumor electric field treatment system. Background Art

[0002] Studies have shown that electric field therapy is effective in treating glioblastoma, non-small cell lung cancer, malignant pleural mesothelioma and other diseases. The electric field applied by this treatment method can affect the aggregation of microtubules, prevent spindle formation, inhibit the process of mitosis, and induce apoptosis of cancer cells.

[0003] In tumor therapy with electric fields, cancer cells have different sensitivities to electric fields of different frequencies. Therefore, for specific cancer cells, a fixed frequency electric field is often applied to interfere with their mitotic process. However, in some cases, researchers may want to apply electric fields of multiple frequencies to cancer cells. Current tumor therapy with electric fields devices have inverter circuits that can output alternating current of different frequencies.

[0004] In order to reduce the impact of high-order harmonics on patients, tumor electric field therapy devices often use filters in the post-stage of the electric field module to suppress harmonics, such as the 3rd, 5th, and 7th harmonics of the fundamental wave. When the electric field frequency changes from the originally set fixed frequency to another frequency, the filter's adaptability to it will decrease to a certain extent. For example, when the electric field frequency is adjusted from 150kHz to 200kHz, the frequency of the harmonics will change accordingly. At this time, the filter's ability to suppress harmonics will decrease to a certain extent, affecting the treatment effect and user experience. In order to adapt the filter, the tumor electric field therapy device needs to replace the corresponding filter before switching the treatment frequency. Replacing the filter will interrupt the electric field, destroy the continuity of the treatment, and affect the treatment effect. Summary of the invention

[0005] It would be advantageous to provide a mechanism that alleviates, mitigates, or even eliminates one or more of the above-mentioned problems.

[0006] According to one aspect of the present disclosure, there is provided a tumor electric field therapy device, comprising: an AC power module, configured to output an alternating electrical signal; an adjustable filter, the adjustable filter being electrically connected to the AC power module to output a filtered alternating electrical signal; and a controller, the controller being configured to control the frequency of the alternating electrical signal output by the AC power module, and to adjust at least the cutoff frequency of the adjustable filter in response to a change in the frequency of the alternating electrical signal.

[0007] According to one embodiment of the present disclosure, the adjustable filter includes an all-pole filter or a non-all-pole filter.

[0008] According to one embodiment of the present disclosure, the all-pole filter includes: an input port, the input port includes a first input terminal and a second input terminal; an output port, the output port includes a first output terminal and a second output terminal; a first capacitor and a second capacitor, the first capacitor and the second capacitor are connected in parallel between the first output terminal and the second output terminal; a first inductor and a second inductor, the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; a first switch, the first switch is connected in parallel with the second inductor; and a second switch, the second switch is connected in series with the second capacitor.

[0009] According to one embodiment of the present disclosure, the non-all-pole filter includes: an input port, the input port includes a first input terminal and a second input terminal; an output port, the output port includes a first output terminal and a second output terminal; a first capacitor and a second capacitor, the first capacitor and the second capacitor are connected in parallel between the first output terminal and the second output terminal; a first inductor and a second inductor, the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; a third inductor and a fourth inductor, the third inductor and the fourth inductor are connected in series between the second input terminal and the second output terminal, wherein the third inductor is differentially symmetrical with the first inductor, and the fourth inductor is differentially symmetrical with the second inductor; a third capacitor and a fourth capacitor, wherein the third capacitor is connected in parallel with the first inductor and the second inductor, The fourth capacitor is connected in parallel with the third inductor and the fourth inductor, and the third capacitor is differentially symmetrical with the fourth capacitor; a first capacitor group and a second capacitor group, wherein the first capacitor group includes a plurality of capacitors connected in parallel with the first inductor and the second inductor, and the second capacitor group includes a plurality of capacitors connected in parallel with the third inductor and the fourth inductor, and the plurality of capacitors of the first capacitor group and the plurality of capacitors of the second capacitor group are differentially symmetrical; and a plurality of switches, wherein a first switch among the plurality of switches is connected in series with the second capacitor, a second switch among the plurality of switches is connected in parallel with the second inductor, a third switch among the plurality of switches is connected in parallel with the fourth inductor, and the remaining switches among the plurality of switches are connected in series with the plurality of capacitors in the first capacitor group and the plurality of capacitors in the second capacitor group correspondingly.

[0010] According to one embodiment of the present disclosure, the first capacitor group further includes a first adjustable capacitor connected in parallel with the first inductor and the second inductor, the second capacitor group further includes a second adjustable capacitor connected in parallel with the third inductor and the fourth inductor, and the first adjustable capacitor and the second adjustable capacitor are differentially symmetrical.

[0011] According to one embodiment of the present disclosure, the non-full-pole filter includes a dual-frequency non-full-pole filter and a dual-notch non-full-pole filter.

[0012] According to one embodiment of the present disclosure, the dual-frequency non-full-pole filter includes: an input port, the input port includes a first input terminal and a second input terminal; an output port, the output port includes a first output terminal and a second output terminal; a first capacitor, the first capacitor is connected in parallel between the first output terminal and the second output terminal; a first inductor and a second inductor, the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; and a second capacitor, the second capacitor is connected in parallel with the first inductor; a third capacitor, the third capacitor is connected in parallel with the second inductor; and a first switch, the first switch is connected in parallel with the third capacitor.

[0013] According to one embodiment of the present disclosure, the double notch non-full-pole filter includes: an input port, the input port includes a first input terminal and a second input terminal; an output port, the output port includes a first output terminal and a second output terminal; a first capacitor, the first capacitor is connected in parallel between the first output terminal and the second output terminal; a first inductor, the first inductor is electrically connected between the first input terminal and the first output terminal; a second capacitor, the second capacitor is connected in parallel with the first inductor; a third capacitor, the third capacitor is connected in parallel with the second capacitor; and a first switch, the first switch is connected in series with the third capacitor.

[0014] According to an embodiment of the present disclosure, the method further includes: a conditioning circuit electrically connected to the tunable filter and configured to condition the filtered alternating electrical signal for output to the electrode array.

[0015] According to one embodiment of the present disclosure, the conditioning circuit includes at least one of a protection circuit, a detection circuit, or an electric field one-group-to-multiple-group output circuit.

[0016] According to an embodiment of the present disclosure, the controller is coupled to the conditioning circuit and is configured to control the conditioning circuit.

[0017] According to one embodiment of the present disclosure, it also includes: a low-pass filter, which is electrically connected between the AC power supply module and the adjustable filter, and is configured to perform low-pass filtering on the alternating electrical signal output by the AC power supply module, and output the alternating electrical signal after low-pass filtering to the adjustable filter.

[0018] According to another aspect of the present disclosure, a tumor electric field treatment system is provided, comprising: a voltage generator as described above; and an electrode array configured to receive an alternating electric signal from the voltage generator to establish a corresponding electric field.

[0019] These and other aspects of the disclosure will be apparent from and elucidated with reference to the embodiments described hereinafter. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Further details, features and advantages of the present disclosure are disclosed in the following description of exemplary embodiments in conjunction with the accompanying drawings, in which:

[0021] Figure 1 is a schematic block diagram of a tumor treating field system according to an exemplary embodiment of the present disclosure;

[0022] Figure 2 is based on Figure 1 A schematic circuit diagram of an AC power supply module of the tumor electric field therapy system shown;

[0023] Figure 3 is a schematic circuit diagram of an all-pole filter according to an exemplary embodiment of the present disclosure;

[0024] Figure 4 is a schematic circuit diagram of a non-all-pole filter according to another exemplary embodiment of the present disclosure;

[0025] Figure 5 is a schematic circuit diagram of a dual-frequency non-all-pole filter according to yet another exemplary embodiment of the present disclosure;

[0026] Figure 6 is a schematic circuit diagram of a double notch non-all-pole filter according to yet another exemplary embodiment of the present disclosure;

[0027] Figure 7 is a schematic circuit diagram of a conditioning circuit according to an exemplary embodiment of the present disclosure;

[0028] Figure 8 is a schematic circuit diagram of a low-pass filter according to an exemplary embodiment of the present disclosure. DETAILED DESCRIPTION

[0029] Exemplary embodiments of the present disclosure are described in detail below and may be used to advantage for a number of reasons, for example, to mitigate or alleviate these undesirable side effects.

[0030] Figure 1 is a schematic block diagram of a tumor electric field treatment system according to an exemplary embodiment of the present disclosure. Figure 1The tumor electric field therapy system includes a voltage generator 50 and an electrode array 40, wherein the voltage generator 50 includes an AC power module 10, an adjustable filter 60 and a controller 30, wherein the AC power module 10 is configured to output an alternating electrical signal; the adjustable filter 60 is electrically connected to the AC power module 10 to output a filtered alternating electrical signal; the controller 30 is configured to control the frequency of the alternating electrical signal output by the AC power module 10, and in response to the frequency change of the alternating electrical signal, at least adjust the cutoff frequency of the adjustable filter 60.

[0031] Figure 2 yes Figure 1 Schematic circuit diagram of AC power module 10 shown. In some examples, reference Figure 2 , the AC power supply module 10 is configured as a full-bridge inverter topology, VCC is a programmable adjustable DC power supply, used to power the AC power supply module 10; S30, S31, S32, S33 are switch devices; the switch devices S30, S31, S32, S33 are controlled to be turned on and off by the controller 30 or the driver (not shown). When S30 and S33 are closed and S31 and S32 are disconnected, the left side of the transformer L30 is high level and the right side is low level; conversely, when S30 and S33 are disconnected and S31 and S32 are closed, the left side of the transformer L30 is low level and the right side is high level, thereby converting the DC signal into an AC signal. The transformer L30 is used to output an AC signal and is electrically connected to the input end of the adjustable filter 60.

[0032] By utilizing the voltage generator 50 provided in the present invention, when the tumor electric field therapy system switches the treatment frequency, the filtering characteristics of the adjustable filter 60 can be quickly changed through a program set in the tumor electric field therapy system, thereby maintaining a low distortion rate of the output electric field waveform while maintaining treatment continuity without interrupting the electric field, thereby maintaining a good treatment effect.

[0033] According to some embodiments, the adjustable filter 60 includes an all-pole filter or a non-all-pole filter. For example, the adjustable filter 60 can be an all-pole filter such as a Butterworth filter, a Chebyshev filter or a Bessel filter, or can be an elliptic function filter, an inverse Chebyshev filter or a notch filter.

[0034] According to some embodiments, the adjustable filter 60 is a full-pole filter, including an input port, the input port including a first input terminal and a second input terminal; an output port, the output port including a first output terminal and a second output terminal; a first capacitor and a second capacitor, the first capacitor and the second capacitor are connected in parallel between the first output terminal and the second output terminal; a first inductor and a second inductor, the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; a first switch, the first switch is connected in parallel with the second inductor; and a second switch, the second switch is connected in series with the second capacitor.

[0035] Figure 3 is a schematic circuit diagram of an all-pole filter 100 according to an exemplary embodiment of the present disclosure. Figure 3 As shown, the full-pole filter 100 includes an input port (input terminal IN+ and input terminal IN-), an output port (output terminal OUT+ and output terminal OUT-), an inductor L1, an inductor L2, a capacitor C1, a capacitor C2, a switch S1 and a switch S2. Among them, the input terminal IN+ and the input terminal IN- are electrically connected to the AC power supply module 10; the capacitor C1 and the capacitor C2 are connected in parallel between the output terminal OUT+ and the output terminal OUT-; the inductor L1 and the inductor L2 are connected in series between the input terminal IN+ and the output terminal OUT+; the switch S2 is connected in series with the capacitor C2; the switch S1 is connected in parallel with the inductor L2; and the output terminal OUT+ and the output terminal OUT- output the filtered alternating electric signal.

[0036] In some examples, the all-pole filter 100 can obtain the following three states by controlling the switches S1 and S2 by the controller 30, namely:

[0037] State 1, S1 is turned on, S2 is turned off, and the effective components of the full-pole filter 100 are L1 and C1;

[0038] State 2, disconnect S1, disconnect S2, the effective components of the full-pole filter 100 are L1, L2 and C1;

[0039] State 3, S1 is disconnected, S2 is turned on, and the effective components of the full-pole filter 100 are L1, L2, C1 and C2.

[0040] In some examples, for the alternating electrical signals with fundamental frequencies of 150kHz, 200kHz and 300kHz output by the AC power module 10, L1, L2, C1 and C2 in the full-pole filter 100 can be configured as 28uH, 14uH, 5.7nF and 2.8nF respectively. When the controller 30 controls the alternating electrical signal output by the AC power module 10 to be 300kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switches S1 and S2 to switch to the above-mentioned state 1, and adjusts the cutoff frequency of the adjustable filter 60 to about 400kHz, which can effectively attenuate the harmonics (900kHz, 1500kHz, etc.) corresponding to the 300kHz fundamental wave; when the controller 30 controls the alternating electrical signal output by the AC power module 10 to be 200kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switches S1 and S2 to switch to the above-mentioned state 1. State 2, adjusting the cutoff frequency of the adjustable filter 60 to about 325kHz, can effectively attenuate the harmonics (600kHz, 1000kHz, etc.) corresponding to the 200kHz fundamental wave; when the controller 30 controls the alternating electrical signal output by the AC power supply module 10 to be 150kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls switches S1 and S2 to switch to the above-mentioned state 3, adjusting the cutoff frequency of the adjustable filter 60 to about 266kHz, can effectively attenuate the harmonics (450kHz, 750kHz, etc.) corresponding to the 150kHz fundamental wave.

[0041] In some examples, all-pole filter 100 state switching is completed within 1 ms.

[0042] In some examples, all-pole filter 100 can be controlled to switch between 2 or 3 states.

[0043] In some examples, a switch can be used to control an inductor with a smaller inductance value, thereby reducing the operating voltage of the switch device. Similarly, a switch can be used to control a capacitor with a smaller capacitance value, thereby reducing the on-current of the switch device, saving design cost and space.

[0044] In some examples, smaller solid-state relays may be selected as switches to save design cost and space.

[0045] In some examples, the capacitor may have a low equivalent series resistance and may be an MMKP82 capacitor.

[0046] In some examples, the inductor may be a vertical inductor with Sendust as the magnetic core.

[0047] In some examples, the inductors L1 and L2 may be replaced by one center-tapped inductor instead of two inductors to reduce the size of the tunable filter 60 .

[0048] In some examples, when the alternating electrical signal received by the input terminals IN+ and IN- of the full-pole filter 100 has been pre-processed (for example, filtered by the low-pass filter 70), and the low-frequency harmonic components are significantly attenuated, the -3dB point frequency of the full-pole filter 100 can be increased to reduce the volume and cost of the adjustable filter 60. For example, when the 3rd and 5th harmonic components of the alternating electrical signal are small, the -3dB point of the full-pole filter 100 can be moved to after the 5th harmonic.

[0049] In some examples, capacitors, inductors, and switches may be added accordingly so that the full-pole filter 100 can obtain more filter states or form a 3rd order, 4th order, or higher order filter to obtain better frequency selection characteristics.

[0050] In some examples, the calculated result can be approached by combining multiple devices (capacitors, inductors, and switches) in parallel or in series, so that the capacitance or inductance of the actual device is as close to or the same as the calculated result as possible.

[0051] According to some embodiments, the adjustable filter 60 is a non-full-pole filter, including an input port, the input port including a first input terminal and a second input terminal; an output port, the output port including a first output terminal and a second output terminal; a first capacitor and a second capacitor, the first capacitor and the second capacitor are connected in parallel between the first output terminal and the second output terminal; a first inductor and a second inductor, the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; a third inductor and a fourth inductor, the third inductor and the fourth inductor are connected in series between the second input terminal and the second output terminal, wherein the third inductor is differentially symmetrical with the first inductor, and the fourth inductor is differentially symmetrical with the second inductor; a third capacitor and a fourth capacitor, wherein the third capacitor is connected in parallel with the first inductor and the second inductor , the fourth capacitor is connected in parallel with the third inductor and the fourth inductor, and the third capacitor is differentially symmetrical with the fourth capacitor; a first capacitor group and a second capacitor group, wherein the first capacitor group includes a plurality of capacitors connected in parallel with the first inductor and the second inductor, and the second capacitor group includes a plurality of capacitors connected in parallel with the third inductor and the fourth inductor, and the plurality of capacitors of the first capacitor group and the plurality of capacitors of the second capacitor group are differentially symmetrical; and a plurality of switches, wherein a first switch among the plurality of switches is connected in series with the second capacitor, a second switch among the plurality of switches is connected in parallel with the second inductor, a third switch among the plurality of switches is connected in parallel with the fourth inductor, and the remaining switches among the plurality of switches are connected in series with the plurality of capacitors in the first capacitor group and the plurality of capacitors in the second capacitor group correspondingly.

[0052] Figure 4 is a schematic circuit diagram of a non-all-pole filter 200 according to another exemplary embodiment of the present disclosure. Figure 4As shown, the non-all-pole filter 200 includes input ports (input terminal IN+ and input terminal IN-), output ports (output terminal OUT+ and output terminal OUT-), inductor L3+, inductor L3-, inductor L4+, inductor L4-, capacitor C7, capacitor C8, capacitor C3+, capacitor C3-, a capacitor group including capacitor C4+ to capacitor Cn+, a capacitor group including capacitor C4- to capacitor Cn+, and multiple switches (S3+ to Sn+ and S3- to Sn-). The input terminal IN+ and the input terminal IN- are electrically connected to the AC power supply module 10; the capacitor C7 and the capacitor C8 are connected in parallel between the output terminal OUT+ and the output terminal OUT-; the inductor L3+ and the inductor L4+ are connected in series between the input terminal IN+ and the output terminal OUT+, the inductor L3- and the inductor L4- are connected in series between the input terminal IN- and the output terminal OUT-, the inductor L3+ and the inductor L3- are differentially symmetrical, and the inductor L4+ and the inductor L4- are differentially symmetrical; the capacitor C3+ is connected in parallel with the inductor L3+ and the inductor L4+, the capacitor C3- is connected in parallel with the inductor L3- and the inductor L4-, and the capacitor C3+ and the capacitor C3- are differentially symmetrical; including the capacitor C4+ to the capacitor The capacitor group of Cn+ is connected in parallel with the inductor L3+ and the inductor L4+, and the capacitor C4+ to the capacitor Cn+ are connected in parallel with each other; the capacitor group including the capacitor C4- to the capacitor Cn- is connected in parallel with the inductor L3- and the inductor L4-, and the capacitor C4- to the capacitor Cn- are connected in parallel with each other; the capacitor C4+ to the capacitor Cn+ and the capacitor C3- to the capacitor Cn- are differentially symmetrical; the switch S6 is connected in series with the capacitor C8; the switch S3+ is connected in parallel with the inductor L4+; the switch S3- is connected in parallel with the inductor L4-; the remaining switches are connected in series with the capacitor C4+ to the capacitor Cn+ and the capacitor C4- to the capacitor Cn- accordingly; the output terminal OUT+ and the output terminal OUT- output the filtered alternating electrical signal.

[0053] According to some embodiments, the first capacitor group in the non-full-pole filter also includes a first adjustable capacitor connected in parallel with the first inductor and the second inductor, and the second capacitor group also includes a second adjustable capacitor connected in parallel with the third inductor and the fourth inductor, and the first adjustable capacitor and the second adjustable capacitor are differentially symmetrical.

[0054] like Figure 4 As shown, the first capacitor group in the non-full-pole filter 200 further includes an adjustable capacitor C6+ connected in parallel with the inductor L3+ and the inductor L4+, and the second capacitor group further includes an adjustable capacitor C6- connected in parallel with the inductor L3- and the inductor L4-.

[0055] In some examples, the C6+ adjustable capacitor can be connected to the circuit to fine-tune the harmonic suppression capability of the circuit. For example, when the output terminal OUT+OUT- of the non-full-pole filter 200 is connected to the harmonic detection module, the C6+ capacitance adjustment and harmonic detection can be closed loop, and C6+ is configured to appropriate parameters to offset the additional harmonic components caused by the filter device error and load deviation as much as possible, so as to achieve real-time adjustable low-distortion AC output. It is worth noting that the adjustable capacitor capacitance range is generally between 10pF and 200pF, and the withstand voltage value is generally within 100Vpp.

[0056] In some examples, the specifications of the differentially symmetrical devices are the same, such as L3+ and L3- are consistent in specifications, thereby forming a differential filter. At the same time, the differentially symmetrical switches can share the same control circuit, that is, the controller 30 can control the differentially symmetrical switches at the same time, such as controlling the conduction and disconnection of S3+ and S3- at the same time, or controlling the conduction and disconnection of S4+ and S4- at the same time, to achieve synchronous control and reduce circuit complexity, such as the input pins of S3+ and S3- can be short-circuited by conductive traces. There can be multiple circuits composed of capacitors and switches between C5+ and Cn+, and between C5- and Cn-. In the non-full-pole filter 200, L3+, L3-, L4+, L4-, S3+, S3-, C7, C8, and S6 constitute the basic components of the filter, and the inductance value is 1 / 2 of the single-ended filter to form a differential filter. C3+ to Cn+ are all devices that form zero points. By controlling the conduction and disconnection of the corresponding switches S4+ to Sn+, the capacitors in series are connected to the filter to form a zero point at a specific frequency. The basic logic of the values ​​of C3+ to Cn+ is:

[0057]

[0058] Among them, C is the required equivalent capacitance value in a certain state, f is the frequency at which significant attenuation is expected (hereinafter referred to as the notch point frequency), and L is the equivalent inductance value connected in parallel with C in the same state. For example, L3+ is configured as 5uH, L4+ is configured as 3uH, and when S3+ is disconnected, the equivalent inductance value of L is 8uH. At this time, if you want to significantly attenuate at 500kHz, C is about 12.67nF, that is, the equivalent capacitance value of the circuit related to C3+ to Cn+ reaches 12.67nF. The value logic of C3- to Cn- is consistent with the value logic of C3+ to Cn+ mentioned above.

[0059] In some examples, the non-all-pole filter 200 has multiple states. The specific number of states depends on the number of lines between C5+ and Cn+, and between C5- and Cn-, but the filter has three basic states, namely:

[0060] State 1, S3+ and S3- are turned on, S6 is turned off, and the effective components in the basic components of the non-all-pole filter 200 are L3+, L3- and C7;

[0061] State 2, disconnect S3+, S3-, disconnect S6, the effective components in the basic components of the non-all-pole filter 200 are L3+, L3-, L4+, L4- and C7;

[0062] State 3, S3+ and S3- are disconnected, S6 is turned on, and the effective devices in the basic elements of the non-all-pole filter 200 are L3+, L3-, L4+, L4-, C7 and C8.

[0063] In some examples, for the alternating electrical signals with fundamental frequencies of 150kHz, 200kHz and 300kHz output by the AC power module 10, the basic elements L3+, L3-, L4+, L4-, C7 and C8 in the non-all-pole filter 200 can be configured as 14uH, 14uH, 7uH, 7uH, 5.7nF and 2.8nF. When the controller 30 controls the alternating electrical signal output by the AC power module 10 to be 300kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switches S3+, S3- and S6 to switch to the above-mentioned state 1 to adjust the cutoff frequency of the adjustable filter 60 to about 400kHz, which can effectively attenuate the harmonics (900kHz, 1500kHz, etc.) corresponding to the 300kHz fundamental wave; when the controller 30 controls the alternating electrical signal output by the AC power module 10 to be 200kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switches S3+, S3- and S6 to switch to In the above state 2, the cutoff frequency of the adjustable filter 60 is adjusted to about 325kHz, which can effectively attenuate the harmonics (600kHz, 1000kHz, etc.) corresponding to the 200kHz fundamental wave; when the controller 30 controls the alternating electrical signal output by the AC power supply module 10 to be 150kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switches S3+, S3- and S6 to switch to adjust the cutoff frequency of the adjustable filter 60 to about 266kHz in the above state 3, which can effectively attenuate the harmonics (450kHz, 750kHz, etc.) corresponding to the 150kHz fundamental wave.

[0064] Further, for the third harmonics of the fundamental frequencies of 150kHz, 200kHz and 300kHz output by the AC power module 10, according to the above formula (1), C3+ and C3- can be configured as 2.23nF, C4+ and C4- can be configured as 1.12nF, C5+ and C5- can be configured as 2.6nF, C7+ to Cn+ can be configured as no device, C7- to Cn- can be configured as no device, C6+ and C6- can be configured as not connected to the circuit, when the control When the alternating electric signal output by the AC power module 10 is controlled by the controller 30 to be 300kHz, in response to the frequency change of the alternating electric signal, the controller 30 controls the switches S3+, S3- and S6 to switch to the above-mentioned state 1, and disconnects the switches S4+, S4-, S5+ and S5-, so that the equivalent capacitance connected in parallel with the inductor is 2.23nF, and the notch point frequency of the adjustable filter 60 is adjusted to about 900kHz, which can effectively attenuate the third harmonic (900kHz) corresponding to the 300kHz fundamental wave; when the controller 30 controls the alternating electric signal output by the AC power module 10 to be 300kHz, the controller 30 controls the switches S3+, S3- and S6 to switch to the above-mentioned state 1, and disconnects the switches S4+, S4-, S5+ and S5-, so that the equivalent capacitance connected in parallel with the inductor is 2.23nF, and the notch point frequency of the adjustable filter 60 is adjusted to about 900kHz, so that the third harmonic (900kHz) corresponding to the 300kHz fundamental wave can be effectively attenuated; when the controller 30 controls the alternating electric signal output by the AC power module 10 to be 300kHz, the controller 30 controls the switches S3+, S3- and S6 to switch to the above-mentioned state 1, and disconnects the switches S4+, S4-, S5+ and S5-, so that the equivalent capacitance connected in parallel with the inductor is 2.23nF, and the notch point frequency of the adjustable filter 60 is adjusted to about 900kHz, and the third harmonic (900kHz) corresponding to the 300kHz fundamental wave can be effectively attenuated; when the controller 30 controls the alternating electric signal output by the AC power module 10 to be 300kHz, the controller When the alternating electric signal output by the AC power module 10 is controlled by the controller 30 to be 200kHz, in response to the frequency change of the alternating electric signal, the controller 30 controls the switches S3+, S3- and S6 to switch to the above-mentioned state 2, and turns on the switches S4+ and S4-, and turns off the switches S5+ and S5-, so that the equivalent capacitance connected in parallel with the inductor is 3.35nF, and the notch point frequency of the adjustable filter 60 is adjusted to about 600kHz, which can effectively attenuate the third harmonic (600kHz) corresponding to the 200kHz fundamental wave. When the controller 30 controls the AC power module 10 to output an alternating electrical signal of 150kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls switches S3+, S3- and S6 to switch to the above-mentioned state 3, and turns on switches S4+, S4-, S5+ and S5-, so that the equivalent capacitance in parallel with the inductor is 5.95nF, and the notch point frequency of the adjustable filter 60 is adjusted to approximately 450kHz, which can effectively attenuate the third harmonic (450kHz) corresponding to the 150kHz fundamental wave.

[0065] In some examples, capacitors, inductors, and switches may be added accordingly to fine-tune the cutoff frequency of the non-full-pole filter 200. For example, the fundamental frequency of the alternating electrical signal is 145kHz, which is close to the fundamental frequency of 150kHz of the alternating electrical signal when the controller 30 controls switches S3+, S3-, and S6 to switch to state 3. A set of capacitors and switches may be added between C5+ and Cn+ and between C5- and Cn-, and the capacitor is selected to be 0.42nF. When the switch is turned on, the total equivalent capacitance is 6.37nF, and the cutoff frequency of the non-full-pole filter 200 is about 435kHz. It is worth noting that the deletion or addition of capacitors, inductors, and switch devices in the non-full-pole filter 200 is not limited to Figure 3 The device combination shown.

[0066] In some examples, the capacitance value can be adjusted to eliminate the effect of a switch with an equivalent output capacitance and a large capacitance value. For example, the equivalent output capacitance of the switch is about 200pF. At this time, when the switch is disconnected, it needs to be equivalent to a 200pF capacitor. Then, for the above three fundamental frequencies of 150kHz, 200kHz and 300kHz, C3+ and C3- can be adjusted to 1.87nF, C4+ and C4- can be adjusted to 1.293nF, and C5+ and C5- can be adjusted to 2.787nF. When the switch is disconnected, the equivalent capacitance of C4+ and S4+ is 0.173nF, the equivalent capacitance of C4- and S4- is 0.173nF, the equivalent capacitance of C5+ and S5+ is 0.187nF, and the equivalent capacitance of C5- and S5- is 0.187nF. In state 1, the controller 30 turns off switches S4+, S4-, S5+, and S5-, and the equivalent capacitance in parallel with the inductor is (1.87+0.173+0.187) nF, i.e., 2.23 nF; similarly, in state 2, the controller 30 turns on switches S4+ and S4-, and turns off switches S5+ and S5-, and the equivalent capacitance in parallel with the inductor is (1.87+1.293+0.187) nF, i.e., 3.35 nF; in state 3, the controller 30 turns on switches S4+, S4-, S5+, and S5-, and the equivalent capacitance in parallel with the inductor is (1.87+1.293+2.787) nF, i.e., 5.95 nF. This method of adjusting capacitance is also applicable to other embodiments.

[0067] According to some embodiments, the non-full-pole filter includes a dual-frequency non-full-pole filter and a dual-notch non-full-pole filter. For example, when the controller 30 controls the AC power module 10 to output an alternating electrical signal having only two different frequencies, the adjustable filter 60 can be a dual-frequency non-full-pole filter or a dual-notch non-full-pole filter.

[0068] According to some embodiments, a dual-band non-all-pole filter includes an input port, the input port includes a first input terminal and a second input terminal; an output port, the output port includes a first output terminal and a second output terminal; a first capacitor, the first capacitor is connected in parallel between the first output terminal and the second output terminal; a first inductor and a second inductor, the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; and a second capacitor, the second capacitor is connected in parallel with the first inductor; a third capacitor, the third capacitor is connected in parallel with the second inductor; and a first switch, the first switch is connected in parallel with the third capacitor.

[0069] Figure 5 is a schematic circuit diagram of a dual-frequency non-all-pole filter 300 according to another exemplary embodiment of the present disclosure. Figure 5As shown, the dual-frequency non-full-pole filter 300 includes an input port (input terminal IN+ and input terminal IN-), an output port (output terminal OUT+ and output terminal OUT-), an inductor L10, an inductor L11, a capacitor C10, a capacitor C11, a capacitor C12, and a switch S11. Among them, the input terminal IN+ and the input terminal IN- are electrically connected to the AC power supply module 10; the output terminal OUT+ and the output terminal OUT- output the filtered alternating electric signal; the capacitor C12 is connected in parallel between the output terminal OUT+ and the output terminal OUT-; the inductor L10 and the inductor L11 are connected in series between the input terminal IN+ and the output terminal OUT+; the capacitor C10 is connected in parallel with the inductor L10; the capacitor C11 is connected in parallel with the inductor L11; and the switch S11 is connected in parallel with the capacitor C11.

[0070] In some examples, for an alternating electrical signal having only two fundamental frequencies output by the AC power module 10 and a frequency ratio close to an odd ratio (for example, f1:f2=3:5 or 5:7 or 3:7, etc.), the dual-frequency non-full-pole filter 300 may have two states, namely:

[0071] State 1, S11 is turned on, and the effective components in the dual-band non-all-pole filter 300 are L10, C10 and C12;

[0072] State 2, S11 is disconnected, and the effective components in the dual-band non-full-pole filter 300 are L10, L11, C10, C11 and C12.

[0073] In some examples, for the alternating electrical signals with fundamental frequencies of 150kHz and 250kHz and a frequency ratio of 3:5 output by the AC power module 10, L10, L11, C10, C11 and C12 in the dual-frequency non-full-pole filter 300 can be configured to be 25uH, 17uH, 1.8nF, 7.36nF and 8.5nF, respectively. When the controller 30 controls the AC power module 10 to output an alternating electrical signal of 250kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switch S11 to switch to the above-mentioned state 1 to adjust the cutoff frequency of the adjustable filter 60 to about 345kHz, and the notch point frequency is 750kHz, which can effectively attenuate the third harmonic (750kHz) corresponding to the 250kHz fundamental wave; when the controller 30 controls the AC power module 10 to output an alternating electrical signal of 150kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switch S11 to switch to the above-mentioned state 2 to adjust the cutoff frequency of the adjustable filter 60 to about 266kHz, and the notch point frequencies are 450kHz and 750kHz, which can effectively attenuate the third harmonic (450kHz) and the fifth harmonic (750kHz) corresponding to the 150kHz fundamental wave.

[0074] In some examples, the frequency ratio f1:f2 of the two fundamental frequencies output by the AC power module 10 is 5:7, and the input AC power can be preprocessed (for example, filtered by a low-pass filter 70) to attenuate the third harmonic, and then the method in the above example is applied to attenuate the fifth and seventh harmonics.

[0075] According to some embodiments, a double notch non-all-pole filter includes an input port, the input port includes a first input terminal and a second input terminal; an output port, the output port includes a first output terminal and a second output terminal; a first capacitor, the first capacitor is connected in parallel between the first output terminal and the second output terminal; a first inductor, the first inductor is electrically connected between the first input terminal and the first output terminal; a second capacitor, the second capacitor is connected in parallel with the first inductor; a third capacitor, the third capacitor is connected in parallel with the second capacitor; and a first switch, the first switch is connected in series with the third capacitor.

[0076] Figure 6 FIG. 4 is a schematic circuit diagram of a double notch non-all-pole filter 400 according to another exemplary embodiment of the present disclosure. Figure 6 As shown, the dual-frequency non-full-pole filter 400 includes an input port (input terminal IN+ and input terminal IN-), an output port (output terminal OUT+ and output terminal OUT-), an inductor L20, a capacitor C20, a capacitor C21, a capacitor C22, and a switch S21. Among them, the input terminal IN+ and the input terminal IN- are electrically connected to the AC power supply module 10; the output terminal OUT+ and the output terminal OUT- output the filtered alternating electric signal; the capacitor C22 is connected in parallel between the output terminal OUT+ and the output terminal OUT-; the inductor L20 is electrically connected between the input terminal IN+ and the output terminal OUT+; the capacitor C20 is connected in parallel with the inductor L20; the capacitor C21 is connected in parallel with the capacitor C20; and the switch S21 is connected in series with the capacitor C21.

[0077] In some examples, for an alternating electrical signal having two fundamental frequencies close to each other (for example, 240 kHz and 260 kHz) output by the AC power module 10, the double-notch non-full-pole filter 400 may have two states, namely:

[0078] State 1, S21 is turned on, and the effective components in the double notch non-full-pole filter 400 are L20, C20, C21 and C22;

[0079] State 2, S21 is disconnected, and the effective components in the double notch non-full-pole filter 400 are L20, C20 and C22.

[0080] In some examples, for fundamental frequencies output by the AC power module 10 of 240 kHz and 260 kHz, L20, C20, C21, and C22 in the double-notch non-full-pole filter 400 may be configured to be 25 uH, 1.665 nF, 0.289 nF, and 8.5 nF, respectively. When the controller 30 controls the AC power module 10 to output an alternating electrical signal of 260kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switch S21 to switch to the above-mentioned state 1 to adjust the cutoff frequency of the adjustable filter 60 to about 345kHz, and the notch point frequency is 780kHz, which can effectively attenuate the third harmonic (780kHz) corresponding to the 260kHz fundamental wave; when the controller 30 controls the AC power module 10 to output an alternating electrical signal of 240kHz, in response to the frequency change of the alternating electrical signal, the controller 30 controls the switch S21 to switch to the above-mentioned state 2 to adjust the cutoff frequency of the adjustable filter 60 to about 345kHz, and the notch point frequency is 720kHz, which can effectively attenuate the third harmonic (720kHz) corresponding to the 240kHz fundamental wave.

[0081] Similar to the embodiments described above, in some examples, the capacitance of the double notch non-full-pole filter 400 can be adjusted to eliminate the influence of a switch with an equivalent output capacitance and a larger capacitance. For example, the equivalent output capacitance of switch S21 is relatively large, such as 200pF, and C20 and C21 can be appropriately adjusted, C20 can be adjusted to 1.53nF, and C21 can be adjusted to 0.424nF. In state 1, the equivalent capacitance in parallel with the inductor is 1.665nF, and the notch point frequency of the double notch non-full-pole filter 400 is 760kHz; in state 2, the equivalent capacitance in parallel with the inductor is 1.954nF, and the notch point frequency of the double notch non-full-pole filter 400 is 720kHz.

[0082] According to some embodiments, the voltage generator 50 further includes a conditioning circuit 20, which is electrically connected to the tunable filter 60 and configured to condition the filtered alternating electrical signal for output to the electrode array 40. Figure 1 As shown, the voltage generator 50 further includes a conditioning circuit 20, which is electrically connected to the tunable filter 60 and configured to condition the filtered alternating electrical signal for output to the electrode array 40. In some examples, the conditioning circuit 20 includes some functional circuits to enable the tunable filter 60 to output an electric field that is more suitable for the tumor of the subject.

[0083] According to some embodiments, the conditioning circuit 20 includes at least one of a protection circuit, a detection circuit, or an electric field one group to multiple groups of output circuits. For example, the conditioning circuit 20 can be a protection circuit, a detection circuit, or an electric field one group to multiple groups of output circuits, or a combination of a protection circuit and a detection circuit, or a combination of a detection circuit and an electric field one group to multiple groups of output circuits, etc.

[0084] Figure 7 is a schematic circuit diagram of a conditioning circuit 20 according to an exemplary embodiment of the present disclosure. Figure 7 As shown, the conditioning circuit 20 includes a protection circuit and a detection circuit, wherein L40 is a current transformer, which is connected in series in the loop for isolation and current detection. The current detection module 21 is connected to the secondary side of L40 to realize the current monitoring function with isolation. L41 is a transformer, which is connected in parallel in the loop for isolation and voltage detection. The voltage detection module 22 is connected to the secondary side of L41 to realize the voltage monitoring function with isolation. The current detection module 21 and the voltage detection module 22 can use a peak detection circuit composed of an operational amplifier, and then provide this information to the controller 30 after an analog-to-digital converter is connected. This method is commonly used in this field and will not be repeated here. D1 and F1 are combined into a hardware protection circuit. D1 can be configured as a bidirectional TVS to protect against external electrical pulse interference. F1 is a fuse, which is used to disconnect conduction and protect the load LOAD when a circuit short-circuit fault occurs.

[0085] According to some embodiments, the controller 30 is coupled to the conditioning circuit 20 and is configured to control the conditioning circuit 20. Figure 1 As shown, the controller 30 is coupled to the conditioning circuit 20 and is configured to control the conditioning circuit 20 .

[0086] According to some embodiments, the voltage generator 50 further includes a low-pass filter, which is electrically connected between the AC power module 10 and the adjustable filter 60 and is configured to perform low-pass filtering on the alternating electrical signal output by the AC power module 10 and output the alternating electrical signal after the low-pass filtering to the adjustable filter 60. Figure 1 As shown, the low-pass filter 70 is electrically connected between the AC power module 10 and the adjustable filter 60 , and is configured to perform low-pass filtering on the alternating electrical signal output by the AC power module 10 , and output the alternating electrical signal after low-pass filtering to the adjustable filter 60 .

[0087] Figure 8 is a schematic circuit diagram of a low pass filter 70 according to an exemplary embodiment of the present disclosure. Figure 8 As shown, the low-pass filter 70 is a second-order differential low-pass filter, including an input terminal IN, an output terminal OUT, a capacitor C23, an inductor L21 and an inductor L22.

[0088] In some examples, the low-pass filter 70 can be a low-pass filter with an inductor at the input terminal IN. Using a low-pass filter with an inductor at the input terminal IN can achieve two effects: 1. Compared with a single program-controlled filter, adding a low-pass filter at the front stage increases the filter's frequency selection capability, making the output stage's sine wave distortion rate lower. 2. The capacitor in the filter with an inductor at the input terminal is subjected to less high-order harmonic energy, and the heat caused by the equivalent series resistance esr is smaller, and the efficiency is higher.

[0089] According to another aspect of the present disclosure, a tumor electric field treatment system is provided, comprising the voltage generator 50 described above; and an electrode array 40 configured to receive an alternating electric signal from the voltage generator 50 to establish a corresponding electric field.

[0090] Although the present disclosure has been illustrated and described in detail in the drawings and the foregoing description, such illustration and description should be considered illustrative and schematic, not restrictive; the present disclosure is not limited to the disclosed embodiments. By studying the drawings, the disclosure and the appended claims, those skilled in the art will be able to understand and implement variations to the disclosed embodiments when practicing the claimed subject matter. In the claims, the word "comprising" does not exclude other elements or steps that are not listed, the indefinite article "a" or "an" does not exclude a plurality, the term "plurality" means two or more, and the term "based on" should be interpreted as "based at least in part on". The mere fact that certain measures are recorded in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.

Claims

1. A tumor electric field treatment device, include: An AC power module is configured to output an alternating electrical signal; an adjustable filter, the adjustable filter being electrically connected to the AC power supply module to output a filtered alternating electrical signal; as well as A controller is configured to control the frequency of the alternating electric signal output by the AC power module, and in response to a change in the frequency of the alternating electric signal, at least adjust a cutoff frequency of the adjustable filter.

2. The tumor electric field treatment device according to claim 1, in, The adjustable filter includes an all-pole filter or a non-all-pole filter.

3. The tumor electric field treatment device according to claim 2, in, The all-pole filter comprises: An input port, the input port comprising a first input terminal and a second input terminal; output ports, the output ports comprising a first output terminal and a second output terminal; A first capacitor and a second capacitor, wherein the first capacitor and the second capacitor are connected in parallel between the first output terminal and the second output terminal; A first inductor and a second inductor, wherein the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; a first switch, the first switch being connected in parallel with the second inductor; and A second switch is connected in series with the second capacitor.

4. The tumor electric field treatment device according to claim 2, in, The non-all-pole filter comprises: An input port, the input port comprising a first input terminal and a second input terminal; output ports, the output ports comprising a first output terminal and a second output terminal; A first capacitor and a second capacitor, wherein the first capacitor and the second capacitor are connected in parallel between the first output terminal and the second output terminal; A first inductor and a second inductor, wherein the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; a third inductor and a fourth inductor, wherein the third inductor and the fourth inductor are connected in series between the second input terminal and the second output terminal, wherein the third inductor is differentially symmetrical with the first inductor, and the fourth inductor is differentially symmetrical with the second inductor; A third capacitor and a fourth capacitor, wherein the third capacitor is connected in parallel with the first inductor and the second inductor, the fourth capacitor is connected in parallel with the third inductor and the fourth inductor, and the third capacitor is differentially symmetrical with the fourth capacitor; a first capacitor group and a second capacitor group, wherein the first capacitor group includes a plurality of capacitors connected in parallel with the first inductor and the second inductor, the second capacitor group includes a plurality of capacitors connected in parallel with the third inductor and the fourth inductor, and the plurality of capacitors of the first capacitor group and the plurality of capacitors of the second capacitor group are differentially symmetrical; and A plurality of switches, wherein a first switch among the plurality of switches is connected in series with the second capacitor, a second switch among the plurality of switches is connected in parallel with the second inductor, a third switch among the plurality of switches is connected in parallel with the fourth inductor, and the remaining switches among the plurality of switches are connected in series with the plurality of capacitors in the first capacitor group and the plurality of capacitors in the second capacitor group, respectively.

5. The tumor electric field treatment device as claimed in claim 4, in, The first capacitor group further includes a first adjustable capacitor connected in parallel with the first inductor and the second inductor, the second capacitor group further includes a second adjustable capacitor connected in parallel with the third inductor and the fourth inductor, and the first adjustable capacitor and the second adjustable capacitor are differentially symmetrical.

6. The tumor electric field treatment device according to claim 2, in, The non-full-pole filter includes a dual-frequency non-full-pole filter and a dual-notch non-full-pole filter.

7. The tumor electric field treatment device according to claim 6, in, The dual-frequency non-all-pole filter comprises: An input port, the input port comprising a first input terminal and a second input terminal; output ports, the output ports comprising a first output terminal and a second output terminal; A first capacitor, the first capacitor is connected in parallel between the first output terminal and the second output terminal; a first inductor and a second inductor, wherein the first inductor and the second inductor are connected in series between the first input terminal and the first output terminal; and a second capacitor, the second capacitor being connected in parallel with the first inductor; a third capacitor, the third capacitor being connected in parallel with the second inductor; and A first switch is connected in parallel with the third capacitor.

8. The tumor electric field treatment device according to claim 6, in, The double notch non-all-pole filter comprises: An input port, the input port comprising a first input terminal and a second input terminal; output ports, the output ports comprising a first output terminal and a second output terminal; A first capacitor, the first capacitor is connected in parallel between the first output terminal and the second output terminal; a first inductor electrically connected between the first input terminal and the first output terminal; a second capacitor, the second capacitor being connected in parallel with the first inductor; a third capacitor, the third capacitor being connected in parallel with the second capacitor; and A first switch is connected in series with the third capacitor.

9. The tumor electric field treatment device according to any one of claims 1 to 8, further comprising: include: A conditioning circuit is electrically connected to the tunable filter and is configured to condition the filtered alternating electrical signal for output to the electrode array.

10. The tumor electric field treatment device according to claim 9, in, The conditioning circuit includes at least one of a protection circuit, a detection circuit or an electric field one-group-to-multiple-group output circuit.

11. The tumor electric field treatment device according to claim 9, in, The controller is coupled to the conditioning circuit and is configured to control the conditioning circuit.

12. The tumor electric field treatment device according to any one of claims 1 to 8, further comprising: include: A low-pass filter is electrically connected between the AC power module and the adjustable filter, and is configured to perform low-pass filtering on the alternating electrical signal output by the AC power module, and output the alternating electrical signal after low-pass filtering to the adjustable filter.

13. A tumor electric field treatment system, include: The tumor electric field treatment device according to any one of claims 1 to 12; as well as The electrode array is configured to receive the alternating electric signal from the tumor electric field treatment device to establish a corresponding electric field.

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