Preparation method of antioxidant microcapsule and buccal product

Abstract

The invention belongs to the technical field of preparation of buccal products, and relates to a preparation method of an antioxidant microcapsule, which comprises the following steps: providing ethyl cellulose and dichloromethane, and dissolving ethyl cellulose in dichloromethane to obtain a suspension; providing a first emulsifier and an antioxidant, adding the first emulsifier and the antioxidant into the turbid liquid, and carrying out first treatment to obtain a first emulsion; providing a second emulsion, adding the first emulsion into the second emulsion, and stirring to obtain a composite microcapsule solution; and performing second treatment on the composite microcapsule solution to obtain the antioxidant microcapsule. The invention also relates to a buccal product. According to the technical scheme provided by the invention, the release speed of the antioxidant can be delayed, and the user experience is improved.

Description

Technical Field

[0001] The present application relates to the technical field of preparation of oral products, and more specifically, to a preparation method of antioxidant microcapsules and an oral product. Background Art

[0002] Oral products contain various flavors and nicotine. Nicotine and the various aldehydes and phenolic substances contained in flavors are easily oxidized, causing product discoloration and deterioration of taste. Therefore, strong reducing antioxidants are usually added to oral products.

[0003] However, since the existing oral product powders have a porous and loose structure and contain a large amount of water, these strong reducing antioxidants suffer large losses in the early stage of the set shelf life and fail to function as antioxidants in the later stage, leading to product deterioration. In addition, although some existing antioxidants have excellent antioxidant effects, they have a peculiar smell that seriously affects the user experience. Summary of the invention

[0004] The technical problem to be solved by the embodiments of the present application is that the antioxidants in existing oral products have poor antioxidant effects and are prone to bring odor, affecting the user experience.

[0005] In order to solve the above technical problems, the present application provides a method for preparing antioxidant microcapsules, which adopts the following technical solution:

[0006] A method for preparing antioxidant microcapsules comprises the following steps:

[0007] Providing ethyl cellulose and dichloromethane, and dissolving the ethyl cellulose in the dichloromethane to obtain a suspension;

[0008] Providing a first emulsifier and an antioxidant, adding the first emulsifier and the antioxidant to the suspension, and performing a first treatment to obtain a first emulsion;

[0009] Providing a second emulsion, adding the first emulsion to the second emulsion, and stirring to obtain a composite microcapsule solution;

[0010] The composite microcapsule solution is subjected to a second treatment to obtain the antioxidant microcapsules.

[0011] Furthermore, in the suspension, the content of ethyl cellulose is 2% to 3%; and / or,

[0012] The solution mass concentration of the suspension is 10 g / L to 100 g / L.

[0013] Furthermore, in the first emulsion, the mass concentration of the antioxidant is 5 g / L to 200 g / L.

[0014] Further, the first emulsifier is selected from one or more of sodium lauryl sulfate, Span-20, Span-60, Span-80, lecithin and sucrose ester; and / or,

[0015] The antioxidant is selected from one or more of sodium sulfite, sodium pyrosulfite, sodium thiosulfate, sodium ascorbate and tea polyphenols.

[0016] Furthermore, the first treatment is a magnetic stirring treatment, and the duration of the magnetic stirring treatment is 30 minutes to 60 minutes.

[0017] Furthermore, the second emulsion is prepared by the following steps:

[0018] providing a second emulsifier and water, and mixing the second emulsifier and water to obtain the second emulsion;

[0019] Wherein, the second emulsifier is selected from one or more of Tween-20, Tween-60, and Tween-80;

[0020] In the second emulsion, the mass volume percentage concentration of the second emulsion is 1% to 3%.

[0021] Furthermore, the second process comprises the following steps:

[0022] The composite microcapsule solution is subjected to sedimentation treatment, wherein the duration of the sedimentation treatment is 12 hours to 24 hours;

[0023] filtering the composite microcapsule solution after the sedimentation treatment to obtain a precipitate;

[0024] The precipitate is subjected to vacuum drying treatment to obtain the antioxidant microcapsules, wherein the vacuum drying treatment temperature is 40° C. to 50° C.

[0025] In order to solve the above technical problems, the present application also provides an oral product, which adopts the following technical solution:

[0026] An oral product comprising nicotine resin, a filler, a humectant, a sweetener, a cooling agent, a flavoring agent, a pH regulator, an antioxidant microcapsule, sodium chloride and water;

[0027] Wherein, the antioxidant microcapsules are prepared by the method for preparing antioxidant microcapsules as described above.

[0028] Furthermore, the weight proportions of the components of the oral product are as follows:

[0029] 4-20 parts of nicotine resin, 30-50 parts of filler, 5-15 parts of humectant, 0.3-15 parts of sweetener, 0.5-5 parts of cooling agent, 2-10 parts of flavoring agent, 0.5-3 parts of pH adjuster, 0.2-2 parts of antioxidant microcapsule, and 20-25 parts of water.

[0030] Further, the filler is selected from one or more of microcrystalline cellulose sodium, starch, maltitol, mannitol, and sorbitol; and / or,

[0031] The humectant is selected from one or more of propylene glycol and propylene glycol; and / or,

[0032] The sweetener is selected from one or more of acesulfame potassium, sucralose, and neotame; and / or,

[0033] The cooling agent is selected from one or more of WS-3 and WS-23; and / or,

[0034] The flavoring agent is selected from one or more of strawberry flavor, sweet orange flavor, watermelon flavor, lemon flavor, mint flavor, and wintergreen flavor; and / or,

[0035] The pH regulator is selected from one or more of sodium bicarbonate and sodium carbonate; and / or,

[0036] The antioxidant microcapsules are selected from one or more of sodium sulfite microcapsules, sodium pyrosulfite microcapsules, sodium thiosulfate microcapsules, sodium ascorbate microcapsules, and tea polyphenol microcapsules.

[0037] Compared with the prior art, the embodiments of the present application have the following beneficial effects:

[0038] The preparation method of the antioxidant microcapsules provided in the present application uses ethyl cellulose as a film-forming agent to form the capsule wall structure of the microcapsules, and adjusts the solubility and lipophilicity of the capsule wall structure of the microcapsules by adding a first emulsifier, so that the antioxidant is coated by the capsule wall structure and the coating effect of the capsule wall structure is improved; in addition, by adding a second emulsion, the physical stability of the microcapsules is further improved, thereby reducing the risk of microcapsule rupture, thereby prolonging the release time of the antioxidant and prolonging the antioxidant effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] In order to more clearly illustrate the scheme of the present application, a brief introduction is given below to the drawings required for use in the description of the embodiments. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0040] Figure 1It is a workflow diagram of the method for preparing the antioxidant microcapsules of the embodiment of the present application. DETAILED DESCRIPTION

[0041] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by technicians in the technical field of this application; the terms used in the specification of the application herein are only for the purpose of describing specific embodiments and are not intended to limit this application; the terms "including" and "having" and any variations thereof in the specification and claims of this application and the above-mentioned drawings are intended to cover non-exclusive inclusions. The terms "first", "second", etc. in the specification and claims of this application or the above-mentioned drawings are used to distinguish different objects, not to describe a specific order.

[0042] Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0043] See also Figure 1 As shown, the present invention provides a method for preparing antioxidant microcapsules, which specifically includes the following steps:

[0044] Step S100, providing ethyl cellulose and dichloromethane, dissolving the ethyl cellulose in the dichloromethane to obtain a suspension;

[0045] In some embodiments, after the ethyl cellulose is added into the dichloromethane, rapid stirring is performed to promote the dissolution of the ethyl cellulose in the dichloromethane.

[0046] Step S200, providing a first emulsifier and an antioxidant, adding the first emulsifier and the antioxidant to the suspension, and performing a first treatment to obtain a first emulsion;

[0047] In some embodiments, a first emulsifier is first added to the suspension to adjust the solubility of the capsule wall structure of the microcapsule, and then an antioxidant is added to the suspension so that the antioxidant can enter the microcapsule, thereby achieving the encapsulation of the antioxidant by the microcapsule;

[0048] The first treatment is a magnetic stirring treatment.

[0049] Step S300, providing a second emulsion, adding the first emulsion to the second emulsion, and stirring to obtain a composite microcapsule solution;

[0050] Step S400, performing a second treatment on the composite microcapsule solution to obtain the antioxidant microcapsules.

[0051] The preparation method of the antioxidant microcapsules provided in the embodiment of the present application uses ethyl cellulose as a film-forming agent to form the capsule wall structure of the microcapsule, and adjusts the solubility and lipophilicity of the capsule wall structure of the microcapsule by adding a first emulsifier, so that the antioxidant is coated by the capsule wall structure and the coating effect of the capsule wall structure is improved; in addition, by adding the second emulsion, the physical stability of the microcapsules is further improved, thereby reducing the risk of microcapsule rupture, thereby prolonging the release time of the antioxidant and prolonging the antioxidant effect.

[0052] In some embodiments, the content of ethyl cellulose in the suspension prepared in step S100 is 2% to 3%. Specifically, the content of ethyl cellulose in the suspension can be set to any one of 2%, 2.5%, 3% or a range formed between any two values.

[0053] In other embodiments, the ethyl cellulose content in the suspension may be controlled by controlling the mass concentration of the ethyl cellulose solution in the suspension.

[0054] In other embodiments, the mass concentration of the suspension is 10 g / L to 100 g / L. Specifically, the mass concentration of the suspension is any one of 10 g / L, 20 g / L, 30 g / L, 40 g / L, 50 g / L, 60 g / L, 70 g / L, 80 g / L, 90 g / L, and 100 g / L, or a range formed between any two values.

[0055] In some embodiments, the mass concentration of the antioxidant in the first emulsion prepared in step S200 is 5 g / L to 200 g / L. Specifically, the mass concentration of the antioxidant in the first emulsion can be adjusted to any one of 5 g / L, 10 g / L, 20 g / L, 50 g / L, 100 g / L, 150 g / L, and 200 g / L, or a range formed between any two values.

[0056] The embodiment of the present application controls the content of the antioxidant entering the microcapsule by controlling the mass concentration of the antioxidant, thereby avoiding the microcapsule from rupturing and affecting the coating effect of the antioxidant.

[0057] In some embodiments, the first emulsifier is selected from one or more of sodium lauryl sulfate, Span-20, Span-60, Span-80, lecithin and sucrose esters.

[0058] In some embodiments, the antioxidant is selected from one or more of sodium sulfite, sodium metabisulfite, sodium thiosulfate, sodium ascorbate, and tea polyphenols.

[0059] In some embodiments, the first treatment in step S200 is a magnetic stirring treatment, and the duration of the magnetic stirring treatment is 30 minutes to 60 minutes. Specifically, the duration of the magnetic stirring treatment can be set to any one of 30 minutes, 40 minutes, 50 minutes, and 60 minutes, or a range formed between any two values.

[0060] In some embodiments, the second emulsion in step S300 is prepared by the following steps:

[0061] providing a second emulsifier and water, and mixing the second emulsifier and water to obtain the second emulsion;

[0062] Wherein, the second emulsifier is selected from one or more of Tween-20, Tween-60, and Tween-80;

[0063] In the second emulsion, the mass volume percentage concentration of the second emulsion is 1% to 3%.

[0064] The embodiment of the present application further adds a second emulsion made of a second emulsifier, which can form an oil-in-water emulsion system on the outside of the microcapsule, and can wrap the water-soluble substance in the oil phase to prevent it from direct contact with external moisture, thereby enhancing its stability; in addition, by forming a stable oil-water two-phase system, the presence of the oil phase in the second emulsifier makes the release rate of the antioxidant relatively slow, thereby achieving a sustained release or slow release effect.

[0065] In some embodiments, the second process in step S400 includes the following steps:

[0066] performing sedimentation treatment on the composite microcapsule solution;

[0067] filtering the composite microcapsule solution after the sedimentation treatment to obtain a precipitate;

[0068] The precipitate is subjected to vacuum drying to obtain the antioxidant microcapsules.

[0069] In some embodiments, the duration of the sedimentation treatment is 12 hours to 24 hours. Specifically, the duration of the sedimentation treatment can be set to one or more of 12 hours, 18 hours, and 24 hours.

[0070] In some embodiments, the temperature of the vacuum drying process is 40°C to 50°C. Specifically, the temperature of the vacuum drying process can be set to one or more of 40°C, 45°C, and 50°C.

[0071] Based on the preparation method of the antioxidant microcapsules as described above, the embodiments of the present application also provide an oral preparation.

[0072] In some embodiments, the oral preparation comprises nicotine resin, filler, humectant, sweetener, cooling agent, flavoring agent, pH adjuster, antioxidant microcapsule, sodium chloride and water;

[0073] Wherein, the antioxidant microcapsules are prepared by the method for preparing antioxidant microcapsules as described above.

[0074] The oral preparation provided in the embodiment of the present application adds antioxidant microcapsules to slowly release the antioxidant, thereby reducing the loss of the antioxidant and prolonging the antioxidant effect; at the same time, due to the slow release rate of the antioxidant, the unpleasant taste of the antioxidant itself can be masked by other substances in the oral preparation, bringing a better taste experience and improving the user experience.

[0075] In some embodiments, 4-20 parts of nicotine resin, 30-50 parts of filler, 5-15 parts of humectant, 0.3-15 parts of sweetener, 0.5-5 parts of cooling agent, 2-10 parts of flavoring agent, 0.5-3 parts of pH adjuster, 0.2-2 parts of antioxidant microcapsules, and 20-25 parts of water.

[0076] In some embodiments, the filler is selected from one or more of sodium microcrystalline cellulose, starch, maltitol, mannitol, and sorbitol.

[0077] In some embodiments, the humectant is selected from one or more of propylene glycol or propylene glycol.

[0078] In some embodiments, the sweetener is selected from one or more of acesulfame potassium, sucralose, and neotame.

[0079] In some embodiments, the cooling agent is selected from one or more of WS-3 and WS-23.

[0080] In some embodiments, the flavoring agent is selected from one or more of strawberry flavor, sweet orange flavor, watermelon flavor, lemon flavor, mint flavor, and wintergreen flavor.

[0081] In some embodiments, the pH regulator is selected from one or more of sodium bicarbonate, sodium carbonate

[0082] In some embodiments, the antioxidant microcapsules are selected from one or more of sodium sulfite microcapsules, sodium metabisulfite microcapsules, sodium thiosulfate microcapsules, sodium ascorbate microcapsules, and tea polyphenol microcapsules.

[0083] The present application is described in detail below through specific embodiments. The following embodiments are only partial embodiments of the present application and are not limitations of the present application.

[0084] Example 1

[0085] Step (1), dissolving 2 g of ethyl cellulose in 50 mL of dichloromethane, stirring until fully dissolved to obtain a suspension;

[0086] Step (2), adding 2 g of Span-80 to the suspension, and then adding 16 mL of sodium sulfite, and stirring in a magnetic stirrer for 30 min to obtain a first emulsion;

[0087] Step (3), adding 1.5% Tween-20 aqueous solution to the first emulsion, stirring at 40° C. for 3 hours to obtain a composite microcapsule solution;

[0088] Step (4), after sedimentation and filtration of the composite microcapsule solution, vacuum drying is performed to obtain sodium sulfite microcapsules;

[0089] Step (5), add 40 g of microcrystalline cellulose, 10 g of propylene glycol, 0.5 g of acesulfame potassium, 0.1 g of sucralose, 2 g of WS-23, 10 g of watermelon flavor, 2 g of sodium sulfite microcapsules, and 2 g of sodium chloride to 20 g of distilled water, mix well, then add 10 g of nicotine resin, and mix well to obtain the oral product.

[0090] Example 2

[0091] The difference between this embodiment and embodiment 1 is that 16 mL of sodium ascorbate is added in step (2).

[0092] Example 3

[0093] The difference between this embodiment and embodiment 1 is that 16 mL of sodium thiosulfate is added in step (2).

[0094] Example 4

[0095] The difference between this embodiment and embodiment 1 is that 16 mL of tea polyphenols is added in step (2).

[0096] Comparative Example 1

[0097] Step (1), to 20 g of distilled water, add 40 g of microcrystalline cellulose, 10 g of propylene glycol, 0.5 g of acesulfame potassium, 0.1 g of sucralose, 2 g of WS-23, 10 g of watermelon flavor, 2 g of sodium sulfite powder, and 2 g of sodium chloride, mix well, then add 10 g of nicotine resin, and mix well to obtain the oral product.

[0098] Comparative Example 2

[0099] Step (1), to 20 g of distilled water, add 40 g of microcrystalline cellulose, 10 g of propylene glycol, 0.5 g of acesulfame potassium, 0.1 g of sucralose, 2 g of WS-23, 10 g of watermelon flavor, 2 g of sodium ascorbate powder, and 2 g of sodium chloride, mix well, then add 10 g of nicotine resin, and mix well to obtain the oral product.

[0100] Comparative Example 3

[0101] Step (1), to 20 g of distilled water, add 40 g of microcrystalline cellulose, 10 g of propylene glycol, 0.5 g of acesulfame potassium, 0.1 g of sucralose, 2 g of WS-23, 10 g of watermelon flavor, 2 g of sodium thiosulfate powder, and 2 g of sodium chloride, mix well, then add 10 g of nicotine resin, and mix well to obtain the oral product.

[0102] Comparative Example 3

[0103] Step (1), to 20 g of distilled water, add 40 g of microcrystalline cellulose, 10 g of propylene glycol, 0.5 g of acesulfame potassium, 0.1 g of sucralose, 2 g of WS-23, 10 g of watermelon flavor, 2 g of tea polyphenol powder, and 2 g of sodium chloride, mix well, then add 10 g of nicotine resin, and mix well to obtain the oral product.

[0104] The oral preparations prepared in Examples 1 to 4 and Comparative Examples 1 to 4 were subjected to accelerated oxidation in a constant temperature and humidity chamber at 60° C. and 90% humidity for 60 h and 360 h, and the nicotine retention rate and the total phenol content were measured. The sensory description of the oral preparations prepared in Examples 1 to 4 and Comparative Examples 1 to 4 was performed. The test results are shown in Table 1 below:

[0105]

[0106]

[0107] Table 1

[0108] According to the records in Table 1, by comparing the experimental data of Example 1 with Comparative Example 1, the experimental data of Example 2 with Comparative Example 2, the experimental data of Example 3 with Comparative Example 3, and the experimental data of Example 4 with Comparative Example 4, it can be known that at 60 hours, the nicotine retention rate and total phenol content of Examples 1 to 4 are lower than those of Comparative Examples 1 to 4. Therefore, it can be known that after the antioxidant is embedded in the microcapsules, the inhibitory effect on the oxidation of nicotine and flavor phenolic substances is weak in the early stage of 60 hours of oxidation acceleration. Therefore, the oral preparation prepared in the examples of the present application is The nicotine retention rate is low, but at 360 hours, the nicotine retention rate and total phenol content of Examples 1 to 4 are higher than those of Comparative Examples 1 to 4, and the color change of the oral products in Examples 1 to 4 is relatively shallow, without obvious odor. Therefore, the antioxidants provided in the examples of the present application have a sustained release effect after being encapsulated by microcapsules, and the antioxidants are slowly released throughout the accelerated oxidation period. In contrast, in the comparative examples where the antioxidants are not encapsulated, the loss of antioxidants in the early stage is large, resulting in the depletion of effective antioxidants in the later stage of acceleration, which leads to more serious oxidation of nicotine and flavors in Comparative Examples 1 to 4.

[0109] In summary, the oral preparation provided in the embodiments of the present application slowly releases the antioxidant by adding antioxidant microcapsules, thereby reducing the loss of antioxidants and prolonging the antioxidant effect; at the same time, due to the slow release rate of the antioxidant, the unpleasant taste of the antioxidant itself can be masked by other substances in the oral preparation, bringing a better taste experience and improving the user experience.

[0110] Obviously, the embodiments described above are only some embodiments of the present application, rather than all embodiments. The preferred embodiments of the present application are given in the accompanying drawings, but they do not limit the patent scope of the present application. The present application can be implemented in many different forms. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive. Although the present application is described in detail with reference to the aforementioned embodiments, for those skilled in the art, it is still possible to modify the technical solutions recorded in the aforementioned specific implementation methods, or to perform equivalent replacement of some of the technical features therein. Any equivalent structure made using the contents of the specification and drawings of this application, directly or indirectly used in other related technical fields, is similarly within the scope of patent protection of this application.

Claims

1. A method for preparing antioxidant microcapsules, characterized in that: The following steps are involved: Providing ethyl cellulose and dichloromethane, and dissolving the ethyl cellulose in the dichloromethane to obtain a suspension; Providing a first emulsifier and an antioxidant, adding the first emulsifier and the antioxidant to the suspension, and performing a first treatment to obtain a first emulsion; Providing a second emulsion, adding the first emulsion to the second emulsion, and stirring to obtain a composite microcapsule solution; The composite microcapsule solution is subjected to a second treatment to obtain the antioxidant microcapsules.

2. The method for preparing the antioxidant microcapsules according to claim 1, characterized in that: In the suspension, the content of ethyl cellulose is 2% to 3%; and / or, The solution mass concentration of the suspension is 10 g / L to 100 g / L.

3. The method for preparing the antioxidant microcapsules according to claim 1, characterized in that: In the first emulsion, the mass concentration of the antioxidant is 5 g / L to 200 g / L.

4. The method for preparing the antioxidant microcapsules according to claim 1, characterized in that: The first emulsifier is selected from one or more of sodium lauryl sulfate, Span-20, Span-60, Span-80, lecithin and sucrose ester; and / or, The antioxidant is selected from one or more of sodium sulfite, sodium pyrosulfite, sodium thiosulfate, sodium ascorbate and tea polyphenols.

5. The method for preparing the antioxidant microcapsules according to claim 1, characterized in that: The first treatment is a magnetic stirring treatment, and the duration of the magnetic stirring treatment is 30 minutes to 60 minutes.

6. The method for preparing the antioxidant microcapsules according to claim 1, characterized in that: The second emulsion is prepared by the following steps: providing a second emulsifier and water, and mixing the second emulsifier and water to obtain the second emulsion; Wherein, the second emulsifier is selected from one or more of Tween-20, Tween-60, and Tween-80; In the second emulsion, the mass volume percentage concentration of the second emulsion is 1% to 3%.

7. The method for preparing the antioxidant microcapsules according to claim 1, characterized in that: The second process comprises the following steps: The composite microcapsule solution is subjected to sedimentation treatment, wherein the duration of the sedimentation treatment is 12 hours to 24 hours; filtering the composite microcapsule solution after the sedimentation treatment to obtain a precipitate; The precipitate is subjected to vacuum drying treatment to obtain the antioxidant microcapsules, wherein the vacuum drying treatment temperature is 40° C. to 50° C.

8. An oral product, characterized in that: Including nicotine resin, filler, humectant, sweetener, cooling agent, flavoring agent, pH adjuster, antioxidant microcapsule, sodium chloride and water; Wherein, the antioxidant microcapsules are prepared by the method for preparing antioxidant microcapsules according to any one of claims 1 to 7.

9. The oral product according to claim 8, characterized in that The weight proportions of the components of the oral product are as follows: 4-20 parts of nicotine resin, 30-50 parts of filler, 5-15 parts of humectant, 0.3-15 parts of sweetener, 0.5-5 parts of cooling agent, 2-10 parts of flavoring agent, 0.5-3 parts of pH adjuster, 0.2-2 parts of antioxidant microcapsule, and 20-25 parts of water.

10. The oral product according to any one of claims 8 or 9, characterized in that: The filler is selected from one or more of microcrystalline cellulose sodium, starch, maltitol, mannitol, and sorbitol; and / or, The humectant is selected from one or more of propylene glycol and propylene glycol; and / or, The sweetener is selected from one or more of acesulfame potassium, sucralose, and neotame; and / or, The cooling agent is selected from one or more of WS-3 and WS-23; and / or, The flavoring agent is selected from one or more of strawberry flavor, sweet orange flavor, watermelon flavor, lemon flavor, mint flavor, and wintergreen flavor; and / or, The pH regulator is selected from one or more of sodium bicarbonate and sodium carbonate; and / or, The antioxidant microcapsules are selected from one or more of sodium sulfite microcapsules, sodium pyrosulfite microcapsules, sodium thiosulfate microcapsules, sodium ascorbate microcapsules, and tea polyphenol microcapsules.

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