Heart valve hatching, sterilizing and liquid filling method and device

By using the vacuum generator and sealing assembly to recover and fill process of the vacuum generator and sealing assembly during the incubation and sterilization of heart valves, the problems of cumbersome operations and solution contamination in the prior art are solved, quantitative filling and residual control of the solution are achieved, and the efficiency and effect of incubation and sterilization are improved.

CN120097267APending Publication Date: 2025-06-06PERMED BIOMEDICAL ENG CO LTD
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Patent Information

Application Number
CN202510366719.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-03-26
Publication Date
2025-06-06

AI Technical Summary

Technical Problem

The existing technology center's central organ valve incubation and sterilization process has problems such as cumbersome operation, easy solution contamination, and irregular filling, resulting in poor incubation and sterilization effects.

Method used

A heart valve incubation and sterilization filling method is adopted. Through the liquid absorption process and the filling process, the vacuum generator and sealing assembly are used to realize quantitative filling and recycling of the solution, avoiding the cumbersomeness of manual operations and the risk of contamination.

Benefits of technology

Quantitative filling of the solution is achieved, controlling and warning of solution residues in the previous process, improving operating efficiency and cleanliness of solution filling, and ensuring the thoroughness of incubation and sterilization.

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Abstract

The invention relates to the technical field of heart valves, in particular to a heart valve hatching, sterilizing and liquid filling method and device, and a liquid recycling and sucking procedure comprises the following steps: placing a packaging bottle in which a solution needs to be sucked on a positioning base; the bottle cap is unscrewed, and the liquid suction sealing assembly is sealed to a bottle opening of a packaging bottle where the solution needs to be sucked; the vacuum generator is started to form negative pressure in the recovery liquid container, so that the solution in the packaging bottle in which the solution needs to be sucked is recovered into the recovery liquid container by liquid suction, the vacuum generator is automatically closed after the set back suction working time is reached, and recovery is stopped; the liquid filling process comprises the following steps: starting a vacuum generator to form negative pressure in a packaging bottle to be filled with liquid; the solution in the liquid filling container is conveyed into a packaging bottle needing to be filled with the solution, the vacuum generator is automatically closed after the set liquid filling working time is up, and liquid filling is completed. Pollution in the solution turnover process is avoided, and the solution filling, spraying and cleaning efficiency is improved.
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Description

Technical Field

[0001] The present invention relates to the technical field of heart valves, and in particular to a heart valve incubation and sterilization liquid filling method and device thereof. Background Art

[0002] When the artificial biological heart valve enters the incubation process, the sterile packaging bottle needs to be replaced to load the biological valve, and the solution used in the filling process in the sterile packaging bottle is used to complete the incubation and sterilization process; at present, the incubation and sterilization filling are both done manually, that is, the liquid is poured into a glass beaker and then poured into the sterile packaging bottle from the beaker, such as Figure 1 As shown, the disadvantages of this operation method are that the operation is cumbersome, the solution turnover is easy to be contaminated, the filling is easy to splash onto the outside of the bottle (residual liquid in the bottle will cause the residual part to crystallize and turn yellow, affecting the appearance and need to be wiped off), and quantitative filling cannot be achieved (a small filling amount will cause the product to not be completely immersed, resulting in the risk of incomplete hatching and sterilization); after the product is incubated, the liquid in the packaging bottle needs to be poured out and the residual liquid on the valve surface needs to be controlled to a certain extent. This operation process is likely to cause excessive liquid residue to affect subsequent sterilization. The solution is easy to stick to the outside of the packaging bottle during the pouring process and needs to be wiped off, which is inconvenient to use and difficult to operate. Summary of the invention

[0003] In view of the problems in the prior art, the present invention provides a heart valve incubation and sterilization filling method and device, which are cleverly designed to realize the standard operation of quantitative solution filling, and realize the control and early warning of the residual solution of the previous process during the liquid replacement operation, thereby replacing the tediousness of manual operations, avoiding pollution in the solution turnover process, and improving the efficiency of solution filling, splashing and cleaning.

[0004] In order to solve the above technical problems, the present invention adopts the following technical solutions: The present invention provides a heart valve incubation and sterilization liquid filling method, which includes a liquid recovery and a liquid filling process; The steps of the liquid recovery process include: Step A1, placing the packaging bottle of the solution to be pumped on the positioning base; Step A2, unscrewing the bottle cap, and sealing the liquid suction sealing assembly at the bottle mouth of the packaging bottle of the solution to be sucked; Step A3, turning on the vacuum generator to form a negative pressure in the recovery liquid container, so that the solution in the packaging bottle to be sucked is sucked back into the recovery liquid container, and at the same time, the solution to be sucked back adhered to the surface of the product in the packaging bottle is separated from the product under the negative pressure back suction state and is sucked back into the recovery liquid container together; Step A4: After the set back-suction working time is reached, the vacuum generator is automatically turned off, and the recovery and suction process is stopped; The steps of the liquid filling process include: Step B1, sealing the liquid filling sealing assembly at the bottle mouth of the packaging bottle to be filled with liquid; Step B2, turning on the vacuum generator to form negative pressure in the packaging bottle to be filled with liquid; Step B3, the solution in the filling container is transported to the packaging bottle to be filled, and the vacuum generator is automatically closed after the set filling working time is reached, and the filling is completed after confirming that the value on the weight meter meets the requirements; Step B4, turn off the vacuum generator, tighten the bottle cap of the filled bottle, and unload the material.

[0005] The present invention also provides a heart valve incubation and sterilization filling device, which includes a recovery and suction mechanism, a filling mechanism, a vacuum generator and a support base, wherein the support base is movably provided with a lifting strip, one end of the lifting strip is provided with a suction station, and the other end of the lifting strip is provided with a filling station, and the support base is also provided with a positioning base, and the positioning base is provided with a bottle positioning groove; the vacuum generator cooperates with the recovery and suction mechanism to suck the solution in the packaging bottle, and the suction station is used to position the packaging bottle from which the solution needs to be sucked; the vacuum generator cooperates with the filling mechanism to fill the solution into the packaging bottle, and the filling station is used to position the packaging bottle to be filled with liquid.

[0006] Among them, the recovery and suction mechanism includes a recovery liquid container, a suction pipe and a first vacuum pipe, the two ends of the first vacuum pipe are respectively connected to the first output end of the vacuum generator and the recovery liquid container, one end of the suction pipe is connected to the recovery liquid container, and the other end of the suction pipe is provided with a suction one-way valve and a suction sealing assembly, and the suction sealing assembly is used to seal the packaging bottle from which the solution needs to be sucked.

[0007] The liquid suction sealing assembly includes a liquid suction sealing rubber pad and a liquid suction tube. The liquid suction tube is arranged through the liquid suction sealing rubber pad. The lower end of the liquid suction tube is used to extend into the packaging bottle. The upper end of the liquid suction tube is connected to the other end of the liquid suction pipe.

[0008] Wherein, the liquid filling mechanism includes a liquid filling container, a liquid filling pipeline and a second vacuum pipeline, one end of the second vacuum pipeline is connected to the second output end of the vacuum generator, the other end of the second vacuum pipeline is connected to the packaging bottle to be filled with liquid, the two ends of the liquid filling pipeline are respectively connected to the liquid filling container and the packaging bottle to be filled with liquid, one end of the liquid filling pipeline is connected to the liquid outlet end of the liquid filling container, and the other end of the liquid filling pipeline is provided with a liquid filling one-way valve and a liquid filling sealing assembly, and the liquid filling sealing assembly is used to seal the packaging bottle to be filled with liquid.

[0009] Among them, the liquid filling sealing assembly includes a liquid filling sealing pad, the other end of the liquid filling pipe passes through the liquid filling sealing pad and extends into the packaging bottle to be filled with liquid, and the other end of the second vacuum pipe passes through the liquid filling sealing pad and extends into the packaging bottle to be filled with liquid.

[0010] Preferably, the positioning base is arranged at an angle.

[0011] Preferably, the bottom wall in the bottle positioning groove is inclined.

[0012] Preferably, a weight sensor is provided at the bottom of the positioning base.

[0013] Preferably, a bottle cap placement groove is also provided on the positioning base.

[0014] Among them, a supporting column is vertically arranged on the supporting base, a connecting hole is arranged in the middle of the lifting strip, the supporting column is inserted into the connecting hole, and the lifting strip can move up and down relative to the supporting column.

[0015] Beneficial effects of the present invention: The present invention has a novel structure. When it is working, the packaging bottle that needs to be sucked of the solution is placed in the bottle positioning groove of the positioning base for positioning. After the bottle cap is opened, the vacuum generator is started. Through the action of the liquid recovery and suction mechanism, the liquid recovery and suction mechanism forms a negative pressure, so that the residual liquid in the packaging bottle that needs to be sucked of the solution is adsorbed into the liquid recovery and suction mechanism. After the liquid recovery and suction is completed, the vacuum generator can be closed; when the solution needs to be poured into the packaging bottle, the vacuum generator is started to form a negative pressure in the packaging bottle that needs to be filled with the solution, and the solution is poured into the packaging bottle that needs to be filled with the solution. After the filling is completed, the bottle cap is tightened to complete the operation; under the above settings, the present invention realizes the standard operation of quantitative filling of the solution; realizes the control and early warning of the residual solution of the previous process during the liquid replacement operation, replaces the tediousness of manual work, avoids pollution in the solution turnover process, and improves the efficiency of solution filling, splashing and wiping. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 The schematic diagram of the operation of incubation and sterilization filling in the prior art.

[0017] Figure 2 The figure is a schematic structural diagram of a heart valve incubation and sterilization filling device of the present invention.

[0018] Figure 3 This is a schematic diagram of the structure of the present invention after the recovery liquid container and the filling liquid container are hidden.

[0019] Figure 4 It is a schematic structural diagram of the lifting strips of the present invention.

[0020] exist Figures 1 to 4 Reference numerals in the drawings include: 100, liquid recovery and suction mechanism; 200, liquid filling mechanism; 300, vacuum generator; 400, supporting base; 500, packaging bottle; 600, controller; 1. Lifting slats; 2. Liquid aspiration station; 3. Liquid filling station; 4. Positioning base; 5. Bottle positioning slot; 6. Recovery liquid container; 7. Liquid aspiration pipeline; 8. First vacuum pipeline; 9. Liquid aspiration one-way valve; 10. Liquid aspiration sealing pad; 11. Liquid aspiration tube; 12. Liquid filling container; 13. Liquid filling pipeline; 14. Second vacuum pipeline; 15. Liquid filling one-way valve; 16. Liquid filling sealing pad; 17. Weight sensor; 18. Bottle cap placement slot; 19. Support column; 20. Connection hole. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work belong to the protection scope of the present invention. It is understood that the drawings are only provided for reference and illustration, and are not used to limit the present invention. The connection relationship shown in the drawings is only for the convenience of clear description and does not limit the connection method.

[0022] It should be noted that when a component is considered to be "connected" to another component, it can be directly connected to another component, or there may be an intermediate component at the same time. Unless otherwise defined, all technical and scientific terms used in this document have the same meaning as those generally understood by technicians in the technical field of the present invention. It should also be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected" and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection, an electrical connection, or the internal connection of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0023] It should also be noted that in the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance. Embodiment 1

[0024] A heart valve incubation and sterilization liquid filling method, characterized in that it includes a liquid recovery and a liquid filling process; The steps of the liquid recovery process include: Step A1, placing the packaging bottle of the solution to be pumped on the positioning base; Step A2, unscrewing the bottle cap, and sealing the liquid suction sealing assembly at the bottle mouth of the packaging bottle of the solution to be sucked; Step A3, turning on the vacuum generator to form a negative pressure in the recovery liquid container, so that the solution in the packaging bottle to be sucked is sucked back into the recovery liquid container, and at the same time, the solution to be sucked back adhered to the surface of the product in the packaging bottle is separated from the product under the negative pressure back suction state and is sucked back into the recovery liquid container together; Step A4: After the set back-suction working time is reached, the vacuum generator is automatically turned off, and after confirming that the value on the weight meter meets the requirements, the recovery and suction process is stopped; The steps of the liquid filling process include: Step B1, sealing the liquid filling sealing assembly at the bottle mouth of the packaging bottle to be filled with liquid; Step B2, turning on the vacuum generator to form negative pressure in the packaging bottle to be filled with liquid; Step B3, the solution in the filling container is transported to the packaging bottle to be filled, and the vacuum generator is automatically closed after the set filling working time is reached, and the filling is completed after confirming that the value on the weight meter meets the requirements; Step B4, turn off the vacuum generator, tighten the bottle cap of the filled bottle, and unload the material. Embodiment 2

[0025] like Figures 2 to 4As shown, a heart valve incubation and sterilization filling device comprises a liquid recovery and suction mechanism 100, a filling mechanism 200, a vacuum generator 300 and a support base 400. The support base 400 is movably provided with a lifting strip 1, one end of the lifting strip 1 is provided with a liquid suction station 2, and the other end of the lifting strip 1 is provided with a filling station 3. The support base 400 is also provided with a positioning base 4, and the positioning base 4 is provided with a bottle positioning groove 5; the vacuum generator 300 cooperates with the liquid recovery and suction mechanism 100 to position the packaging bottle 500. The solution in the packaging bottle 500 is sucked to separate the product from the solution. The suction station 2 is used to position the packaging bottle 500 from which the solution needs to be sucked; the vacuum generator 300 cooperates with the filling mechanism 200 to quantitatively fill the solution into the packaging bottle 500, and the filling station 3 is used to position the packaging bottle 500 to be filled; wherein the suction volume of the vacuum generator 300 is not less than 10L / minute, and the vacuum degree is not less than 0.086Mpa; wherein the lifting strip 1 can rotate relative to the supporting base 400, so that the positions of the filling station 3 and the suction station 2 can be switched. Specifically, the embodiment of the present application is cleverly designed. When it is working, the packaging bottle 500 that needs to be sucked of the solution is placed in the bottle positioning groove 5 of the positioning base 4 for positioning. After the bottle cap is opened, the vacuum generator 300 is started, and the recovery and suction mechanism 100 is used to form a negative pressure, so that the residual liquid in the packaging bottle 500 that needs to be sucked of the solution is adsorbed into the recovery and suction mechanism 100. After the recovery and suction is completed, the vacuum generator 300 can be closed; when the solution needs to be poured into the packaging bottle 500, the vacuum generator 300 is started, so that a negative pressure is formed in the packaging bottle 500 that needs to be filled with the solution, and the solution is poured into the packaging bottle 500 that needs to be filled with the solution. After the filling is completed, the bottle cap is tightened to complete the operation; under the above settings, the present invention realizes the standard operation of quantitative filling of the solution; realizes the control and early warning of the residual solution of the previous process during the liquid replacement operation; replaces the tediousness of manual work, avoids the pollution in the solution turnover process, and improves the efficiency of solution filling, splashing and wiping.

[0026] In the embodiment of the present application, a weight sensor 17 is provided at the bottom of the positioning base 4; wherein, the heart valve incubation and sterilization filling device also includes a controller 600, and the controller 600 is electrically connected to the weight sensor 17 and the vacuum generator 300 respectively, and the controller 600 is also provided with a plurality of control buttons for controlling the switching of different output ends of the vacuum generator 300; the controller 600 is also provided with a display screen, and the weight detected by the weight sensor 17 can be displayed on the display screen, so that the operator can confirm whether the packaging bottle 500 has completed the liquid aspiration or the filling, that is, it can be determined whether the residual state of the solution in the packaging bottle 500 that needs to be aspirated and whether the filling volume meets the requirements.

[0027] In the embodiment of the present application, the recovery and suction mechanism 100 includes a recovery liquid container 6, a suction pipe 117 and a first vacuum pipe 8, the two ends of the first vacuum pipe 8 are respectively connected to the first output end of the vacuum generator 300 and the recovery liquid container 6, one end of the suction pipe 117 is connected to the recovery liquid container 6, and the other end of the suction pipe 117 is provided with a suction one-way valve 9 and a suction sealing assembly, and the suction sealing assembly is used to seal the packaging bottle 500 that needs to be sucked solution; wherein, the suction sealing assembly includes a suction sealing rubber pad 10 and a suction pipe 11, the suction pipe 11 is arranged through the suction sealing rubber pad 10, the lower end of the suction pipe 11 is used to extend into the packaging bottle 500, and the upper end of the suction pipe 11 is connected to the other end of the suction pipe 117.

[0028] Specifically, under the above setting, when the recovery and suction mechanism 100 is working, the vacuum generator 300 is started, and the packaging bottle 500 from which the solution needs to be sucked forms a negative pressure, and the residual solution in the packaging bottle 500 from which the solution needs to be sucked is sucked back into the recovery liquid container 6, thereby realizing standardized operations in the packaging bottle 500 container; wherein, the suction sealing pad 10 has a sealing effect to prevent the solution from falling and to prevent the packaging bottle 500 from being contaminated by the outside.

[0029] In the embodiment of the present application, the liquid filling mechanism 200 includes a liquid filling container 12, a liquid filling pipe 13 and a second vacuum pipe 14, one end of the second vacuum pipe 14 is connected to the second output end of the vacuum generator 300, and the other end of the second vacuum pipe 14 is connected to the packaging bottle 500 to be filled with liquid. The two ends of the liquid filling pipe 13 are respectively connected to the liquid filling container 12 and the packaging bottle 500 to be filled with liquid, one end of the liquid filling pipe 13 is connected to the liquid outlet end of the liquid filling container 12, and the other end of the liquid filling pipe 13 is provided with a liquid filling check valve 15 and a liquid filling sealing assembly, and the liquid filling sealing assembly is used to seal the packaging bottle 500 to be filled with liquid; the liquid filling sealing assembly includes a liquid filling sealing pad 16, the other end of the liquid filling pipe 13 passes through the liquid filling sealing pad 16 and then extends into the packaging bottle 500 to be filled with liquid, and the other end of the second vacuum pipe 14 passes through the liquid filling sealing pad 16 and then extends into the packaging bottle 500 to be filled with liquid.

[0030] Specifically, under the above setting, when the filling mechanism 200 is working, the vacuum generator 300 is started, so that a negative pressure is formed on the packaging bottle 500 that needs to be filled with liquid, and the solution in the filling container 12 enters the packaging bottle 500 that needs to be filled with liquid through the filling pipe 13. Furthermore, the weight sensor 17 can be used to detect whether the packaging bottle 500 to be filled with liquid meets the requirements.

[0031] In the embodiment of the present application, the positioning base 4 is arranged at an angle; wherein the inclination angle of the positioning base 4 is 1°~3° relative to the horizontal plane; preferably, the inclination angle of the positioning base 4 is 1°; this is conducive to the solution in the packaging bottle 500 being sucked clean, reducing or even avoiding the situation of solution residue.

[0032] In the embodiment of the present application, the positioning base 4 is also provided with a bottle cap placement groove 18. Specifically, under this arrangement, the bottle caps of the packaging bottles 500 are conveniently placed, conveniently stored, and prevented from falling and contamination.

[0033] In the embodiment of the present application, a support column 19 is vertically arranged on the support base 400, and a connecting hole 20 is arranged in the middle of the lifting slat 1, and the support column 19 is inserted into the connecting hole 20, and the lifting slat 1 can move up and down relative to the support column 19; further, an external thread is arranged on the outer periphery of the support column 19, and an internal thread is arranged in the connecting hole 20, and the support column 19 is threadedly connected to the connecting hole 20; under the above setting, rotating the lifting slat 1 can drive it to rise or move down along the support column 19. Embodiment 3

[0034] The third embodiment of the present application is different from the first embodiment in that the bottom wall of the bottle positioning groove 5 is inclined. Specifically, under this setting, its function is similar to that of the positioning base 4 being inclined; that is, the inclination angle of the bottom wall of the bottle positioning groove 5 is 1° to 3° relative to the horizontal plane; it is conducive to the solution in the packaging bottle 500 being sucked clean, reducing or even avoiding the situation of solution residue.

[0035] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention is disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technician familiar with the profession can make some changes or modifications to equivalent embodiments of equivalent changes by using the technical contents disclosed above without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent changes and modifications made to the above embodiments according to the technology of the present invention are within the scope of the technical solution of the present invention without departing from the content of the technical solution of the present invention.

Claims

1. A heart valve incubation and sterilization filling method, characterized in that: It includes a liquid recovery and a liquid filling process; The steps of the recovery and absorption process include: Step A1, placing the packaging bottle of the solution to be pumped on the positioning base; Step A2, unscrewing the bottle cap, and sealing the liquid suction sealing assembly at the bottle mouth of the packaging bottle of the solution to be sucked; Step A3, turning on the vacuum generator to form a negative pressure in the recovery liquid container, so that the solution in the packaging bottle that needs to be sucked is sucked and recovered into the recovery liquid container; Step A4: After the set back-suction working time is reached, the vacuum generator is automatically turned off, and the recovery and suction process is stopped; The steps of the liquid filling process include: Step B1, sealing the liquid filling sealing assembly at the bottle mouth of the packaging bottle to be filled with liquid; Step B2, turning on the vacuum generator to form negative pressure in the packaging bottle to be filled with liquid; Step B3, the solution in the liquid filling container is transported to the packaging bottle to be filled, and the filling is completed; Step B4, turn off the vacuum generator, tighten the bottle cap of the filled bottle, and unload the material.

2. A heart valve incubation and sterilization filling device, characterized in that: It includes a liquid recovery and suction mechanism, a liquid filling mechanism, a vacuum generator and a support base, wherein a lifting strip is movably provided on the support base, a liquid suction station is provided at one end of the lifting strip, and a liquid filling station is provided at the other end of the lifting strip, and the lifting strip is rotated so that the positions of the liquid suction station and the liquid filling station are interchanged; The support base is also provided with a positioning base, and the positioning base is provided with a bottle positioning groove; the vacuum generator cooperates with the recovery and suction mechanism to suck the solution in the packaging bottle so that the product and the solution are separated, and the suction station is used to locate the packaging bottle from which the solution needs to be sucked; the vacuum generator cooperates with the filling mechanism to quantitatively fill the solution into the packaging bottle, and the filling station is used to locate the packaging bottle to be filled with liquid.

3. A heart valve incubation and sterilization filling device according to claim 2, characterized in that: The recovery and suction mechanism includes a recovery liquid container, a suction pipe and a first vacuum pipe, wherein the two ends of the first vacuum pipe are respectively connected to the first output end of the vacuum generator and the recovery liquid container, one end of the suction pipe is connected to the recovery liquid container, and the other end of the suction pipe is provided with a suction one-way valve and a suction sealing assembly, and the suction sealing assembly is used to seal the packaging bottle from which the solution needs to be sucked.

4. A heart valve incubation and sterilization liquid filling device according to claim 3, characterized in that: The liquid suction sealing assembly includes a liquid suction sealing rubber pad and a liquid suction tube. The liquid suction tube is arranged through the liquid suction sealing rubber pad. The lower end of the liquid suction tube is used to extend into the packaging bottle. The upper end of the liquid suction tube is connected to the other end of the liquid suction pipe.

5. A heart valve incubation and sterilization liquid filling device according to claim 1, characterized in that: The liquid filling mechanism includes a liquid filling container, a liquid filling pipeline and a second vacuum pipeline, one end of the second vacuum pipeline is connected to the second output end of the vacuum generator, the other end of the second vacuum pipeline is connected to the packaging bottle to be filled with liquid, the two ends of the liquid filling pipeline are respectively connected to the liquid filling container and the packaging bottle to be filled with liquid, one end of the liquid filling pipeline is connected to the liquid outlet end of the liquid filling container, and the other end of the liquid filling pipeline is provided with a liquid filling one-way valve and a liquid filling sealing assembly, and the liquid filling sealing assembly is used to seal the packaging bottle to be filled with liquid.

6. A heart valve incubation and sterilization liquid filling device according to claim 5, characterized in that: The liquid filling sealing assembly includes a liquid filling sealing rubber pad, the other end of the liquid filling pipe passes through the liquid filling sealing rubber pad and then extends into the packaging bottle to be filled with liquid, and the other end of the second vacuum pipe passes through the liquid filling sealing rubber pad and then extends into the packaging bottle to be filled with liquid.

7. A heart valve incubation and sterilization liquid filling device according to claim 2, characterized in that: The positioning base is arranged in an inclined manner.

8. A heart valve incubation and sterilization liquid filling device according to claim 2, characterized in that: A weight sensor is arranged at the bottom of the positioning base.

9. A heart valve incubation and sterilization liquid filling device according to claim 2, characterized in that: The positioning base is also provided with a bottle cap placement groove.

10. A heart valve incubation and sterilization liquid filling device according to claim 2, characterized in that: A supporting column is vertically arranged on the supporting base, a connecting hole is arranged in the middle of the lifting slat, the supporting column is inserted into the connecting hole, and the lifting slat can be rotated relative to the supporting column so that the lifting slat can move up and down.