Three-dimensional water-locking moisturizing composition, preparation method and application thereof

Abstract

The present application relates to the daily chemical technical field, especially to a three-dimensional water-locking moisturizing composition and a preparation method and application thereof.The preparation raw material of the composition comprises: an aqueous phase, an oil phase and an emulsifier; wherein the oil phase comprises: butyrospermum parkii butter, cetyl stearyl alcohol olivate, sorbitan olivate and polymethylsilsesquioxane.The moisturizing cream provided by the present application has double effects: water supplementing + water locking, contains a moisture absorbent, can absorb moisture in the environment and deliver it to the skin surface, and helps the skin to keep moist; water locking: contains a moisturizing agent, forms a protective film on the skin surface, and reduces water loss.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of daily chemical technology, and in particular to a three-dimensional water-locking moisturizing composition, a preparation method and application thereof. BACKGROUND

[0002] Skin moisturizing is an important part of maintaining skin health. Skin water loss can cause dryness, tightness, sensitivity, and even accelerate aging. When the skin barrier (stratum corneum) is damaged, water is more easily evaporated. Common causes include over-cleaning, using irritating skincare products, and frequent exfoliation.

[0003] Common causes of skin water loss: 1. Damaged skin barrier: When the skin barrier (stratum corneum) is damaged, water is more easily evaporated. Common causes include over-cleaning, using irritating skincare products, and frequent exfoliation. Environmental factors: Dry air, cold weather, or long-term exposure to air-conditioned rooms can accelerate water evaporation. Ultraviolet radiation can also damage the skin barrier, leading to water loss. 3. Lifestyle: Insufficient water intake, excessive intake of caffeinated or alcoholic beverages can reduce skin water content. Lack of sleep or stress can affect skin repair ability.

[0004] Effective methods to reduce skin water loss: 1. Repair the skin barrier: Use skincare products containing ceramides, cholesterol, and fatty acids, which can strengthen the skin barrier. Avoid frequent use of acid-based products (if acid, AHA), especially when the skin is sensitive. 2. Increase moisturizing steps: Hydrate + lock in moisture: First use a hydrating product (such as a hyaluronic acid-containing serum), then use a occlusive moisturizer (such as a vaseline or petrolatum-containing cream) to lock in moisture. After using a spray, remember to pat excess water with a paper towel and apply moisturizer in time.

[0005] In extremely dry environments, certain types of moisturizing creams may indeed exacerbate skin water loss. This phenomenon is often related to the composition of the moisturizing product, especially its hygroscopic ingredients (such as glycerin, urea, hyaluronic acid, etc.). Hygroscopic ingredients (such as glycerin, hyaluronic acid, propylene glycol) absorb water from the environment and transport it to the stratum corneum, helping to keep the skin moist; but if the humidity of the surrounding environment is extremely low (usually less than 30%), the hygroscopic ingredients may in turn absorb water from the deep layers of the skin, causing water to evaporate from the skin into the air, exacerbating dryness. If the skin barrier function is weak and cannot effectively lock in moisture, even if a moisturizing cream is used, water will quickly be lost through trans-epidermal water loss (TEWL).

[0006] To this end, the present application provides a three-dimensional water-locking moisturizing composition, a preparation method and application thereof. SUMMARY

[0007] To solve the above technical problems, the present application provides a three-dimensional water-locking composition, raw materials for preparing the composition comprising: an aqueous phase, an oil phase, and an emulsifier;

[0008] The oil phase comprises: butyrospermum parkii butter, cetyl stearyl olivate, sorbitan olivate, and dimethicone.

[0009] As an embodiment of the present application, the viscosity of the dimethicone is 1.0-3.0 cps at 25°C.

[0010] As an embodiment of the present application, the composition further comprises a citrus reticulata peel extract, which is prepared by fermentation.

[0011] As an embodiment of the present application, the raw materials for preparing the composition further comprise: cetyl alcohol ethylhexanoate, common citron peel oil, and tangerine peel oil.

[0012] The present application provides a three-dimensional water-locking moisturizing cream prepared from the three-dimensional water-locking composition.

[0013] As an embodiment of the present application, the raw materials for preparing the three-dimensional water-locking moisturizing cream comprise:

[0014] A-phase raw materials: isononyl isononanoate, PEG-100 stearate, glyceryl stearate, cetyl stearyl alcohol, butyrospermum parkii butter, cetyl stearyl olivate, sorbitan olivate, and dimethicone;

[0015] B-phase raw materials: water, glycerol, butylene glycol, betaine, carbomer, hydrogenated lecithin, and disodium EDTA;

[0016] C-phase raw materials: water and arginine;

[0017] D-phase raw materials: butylene glycol and caprylhydroxamic acid;

[0018] E-phase raw materials: water and nicotinamide;

[0019] F-phase raw materials: water and tetrahydro methyl pyrimidine carboxylic acid;

[0020] G-phase raw materials: water, lauryl dimethicone / polyglyceryl-3 crosslinked polymer, polymethylsilsesquioxane, caprylyl glycol, and phenoxyethanol;

[0021] H phase raw materials: Cordyceps sinensis extract, 1,3-propanediol, 1,2-hexanediol, galactofermentum filtrate, p-hydroxyacetophenone, ethylhexylglycerin, Cynanchum atratum extract, Sophora angustifolia root extract, Gynostemma pentaphyllum extract, xylitol-based glucoside, anhydrous xylitol, xylitol, Prunus speciosa flower extract, maltodextrin glucoside, hydrogenated starch hydrolysate, bisabalol, isohexadecane, cetyl alcohol ethylhexanoate, common citron (Citrus medicavulgaris) peel oil, tangerine (Citrus tangerina) peel oil;

[0022] I phase raw materials: water, Thermus thermophilus ferment filtrate, soluble collagen, butylene glycol, ethylhexylglycerin.

[0023] As an embodiment of the present application, the preparation raw materials of the moisturizing cream include, by mass:

[0024] A phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetylstearyl alcohol 1.2 parts, Butyrospermum parkii butter 1 part, cetylstearyl alcohol olivate 0.5 parts, sorbitan olivate 0.5 parts, dimethicone 0.5 parts, squalane 0.5 parts, tocopheryl acetate 0.2 parts;

[0025] B phase raw materials: water 30 parts, glycerin 5 parts, butylene glycol 1 part, betaine 0.5 parts, carbomer 0.2 parts, hydrogenated lecithin 0.11 parts, disodium EDTA 0.11 parts;

[0026] C phase raw materials: water 5 parts, arginine 0.22 parts;

[0027] D phase raw materials: butylene glycol 1 part, caprylhydroxamic acid 0.05 parts;

[0028] E phase raw materials: water 5 parts, nicotinamide 0.11 parts;

[0029] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 parts;

[0030] G phase raw materials: water 30.69 parts, lauryl dimethicone / polyglyceryl-3 crosslinked polymer 0.3 parts, polymethylsilsesquioxane 0.3 parts, caprylyl glycol 0.1 parts, phenoxyethanol 0.1 parts;

[0031] H phase raw materials: Cordyceps sinensis extract 1 part, 1,3-propanediol 0.1 part, 1,2-hexanediol 0.15 part, galactose yeast-like fungus fermentation product filtrate 1 part, p-hydroxyacetophenone 0.05 part, ethylhexylglycerin 0.1 part, Cynanchum atratum extract 0.05 part, Sophora angustifolia root extract 0.1 part, Gynostemma pentaphyllum extract 0.1 part, xylitol-based glucoside 0.1 part, dehydrated xylitol 0.1 part, xylitol 0.1 part, Prunus speciosa flower extract 0.4 part, malt oligosaccharide glucoside 0.1 part, hydrogenated starch hydrolysate 0.1 part, farnesol 0.11 part, isohexadecane 0.05 part, cetyl alcohol ethylhexanoate 0.1 part, common Citrus medica vulgaris peel oil 1.5 parts, Citrus tangerina peel oil 1 part;

[0032] I phase raw materials: water 0.1 part, Thermus thermophilus fermentation product 0.001 part, soluble collagen 0.001 part, butanediol 0.001 part, ethylhexylglycerin 0.001 part.

[0033] As an embodiment of the present application, the preparation method of the three-dimensional water-locking moisturizing cream is as follows:

[0034] S1. Do good hygiene cleaning work, and strictly clean and disinfect the equipment and utensils;

[0035] S2. Put the A phase raw materials into the oil pot one by one, stir to heat to 80-85°C, and keep for a period of time to ensure complete dissolution of the material, and reserve;

[0036] S3. Put the B phase raw materials into the emulsifying pot one by one, stir to heat to 85-90°C, and keep for a period of time to ensure complete dissolution of the material, then pour the A phase into the emulsifying pot, homogenize and stir evenly, add the C phase raw materials, homogenize and stir evenly, and then cool down;

[0037] S4. Cool down to 60-65°C, add the pre-dissolved D phase raw materials, and stir evenly, and continue to cool down;

[0038] S5. Cool down to 40-45°C, add the H and I phases and the pre-dissolved E, F and G phases, and stir evenly;

[0039] S6. Send for inspection, and after passing the inspection, discharge the material, and after passing the micro-inspection, pour the material into the filling machine for filling, and it is ready.

[0040] As an embodiment of the present application, the D, E, F, and G phase raw materials are dissolved in advance before being added to the pot.

[0041] As an embodiment of the present application, the three-dimensional water-locking moisturizing cream is applied in the field of daily chemicals.

[0042] By adopting the technical scheme, the present application has the following beneficial effects:

[0043] 1. Dual efficacy: moisturizing + water-locking, containing a moisture-absorbing agent that can absorb moisture from the environment and deliver it to the skin surface, helping the skin to stay hydrated; water-locking: containing a moisturizing agent that forms a protective film on the skin surface, reducing water loss.

[0044] 2. Suitable for different skin types: nourishing moisturizing cream provides deep nourishment. It does not block pores and balances water and oil at the same time. The mild formula does not contain alcohol or fragrance, reducing the risk of irritation.

[0045] 3. The cream has a texture between a cream and a gel, with good spreadability, and can be quickly absorbed after application, without feeling heavy or sticky.

[0046] 4. The moisturizing cream can provide long-term moisture support for the skin and prevent skin dryness caused by environmental factors such as wind, cold or air-conditioned rooms. DETAILED DESCRIPTION

[0047] The technical solutions of the present application will be described below in a clear and complete manner. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0048] The present application provides a three-dimensional water-locking moisturizing cream, according to mass parts, the preparation raw materials of the moisturizing cream comprise:

[0049] A phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetylstearyl alcohol 1.2 parts, butyrospermum parkii butter 1 part, cetylstearyl alcohol oleate 0.5 parts, sorbitan oleate 0.5 parts, dimethicone 0.5 parts, squalane 0.5 parts, tocopheryl acetate 0.2 parts;

[0050] B phase raw materials: water 30 parts, glycerol 5 parts, butanediol 1 part, betaine 0.5 parts, carbomer 0.2 parts, hydrogenated lecithin 0.11 parts, disodium EDTA 0.11 parts;

[0051] C phase raw materials: water 5 parts, arginine 0.22 parts;

[0052] D phase raw materials: butanediol 1 part, octanoyl hydroxamic acid 0.05 parts;

[0053] E phase raw materials: water 5 parts, nicotinamide 0.11 parts;

[0054] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 parts;

[0055] G phase raw materials: water 30.69 parts, lauryl polydimethylsiloxane / polyglyceryl-3 crosslinked polymer 0.3 parts, polymethylsilsesquioxane 0.3 parts, octisalate 0.1 parts, phenoxyethanol 0.1 parts;

[0056] H phase raw materials: Cordyceps sinensis extract 1 part, 1,3-propanediol 0.1 part, 1,2-hexanediol 0.15 part, filtrate of Saccharomyces galactosus-like fungus fermentation product 1 part, p-hydroxyacetophenone 0.05 part, ethylhexylglycerin 0.1 part, Cynanchum atratum extract 0.05 part, Sophora angustifolia root extract 0.1 part, Gynostemma pentaphyllum extract 0.1 part, xylitol-based glucoside 0.1 part, anhydrous xylitol 0.1 part, xylitol 0.1 part, Prunus speciosa flower extract 0.4 part, malt oligosaccharide glucoside 0.1 part, hydrogenated starch hydrolysate 0.1 part, farnesol 0.11 part, isohexadecane 0.05 part, cetyl alcohol ethylhexanoate 0.1 part, common Citrus medica vulgaris peel oil 1.5 parts, Citrus tangerina peel oil 1 part;

[0057] I phase raw materials: water 0.1 parts, Thermus thermophilus fermentation product 0.001 parts, soluble collagen 0.001 parts, butanediol 0.001 parts, ethylhexylglycerin 0.001 parts.

[0058] Among them, the preparation method of the Cordyceps sinensis extract is as follows:

[0059] (1) Take Cordyceps sinensis, wash and dry, then crush and sieve; wash and dry the citrus peel, then cut it into pieces;

[0060] (2) Mix the Cordyceps sinensis powder and citrus peel pieces, then add them to the culture solution and mix evenly, then continue to inoculate the strain, the inoculation amount is 10%, after aerobic fermentation at 28°C for 72h, remove the filter residue to obtain the Cordyceps sinensis extract.

[0061] The bacteria strain is Candida rugosa Candida 32586 and Aspergillus niger Aspergillus 40048; the inoculation ratio is 3:2.

[0062] The components of the culture solution include beef infusion powder 3.0 g, protein peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast infusion powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, and distilled water, supplemented to 1000 mL.

[0063] The preparation method of the common citron (CITRUS MEDICA VULGARIS) peel oil and the tangerine (CITRUS TANGERINA) peel oil is as follows:

[0064] (1) The common citron (CITRUS MEDICA VULGARIS) peel and the tangerine (CITRUS TANGERINA) peel are cut and then added into the culture solution to mix uniformly, and then the bacteria strain is continuously inoculated, the inoculation amount is 8%, after aerobic fermentation at 28°C for 72 h, the filter residue is removed, and then the oil layer is taken after standing to obtain the common citron (CITRUS MEDICA VULGARIS) peel oil and the tangerine (CITRUS TANGERINA) peel oil.

[0065] The bacteria strain is grape juice spore Hanseniaspora 1959 and Aspergillus niger Aspergillus 40048; the inoculation ratio is 2:2.

[0066] The components of the culture solution include beef infusion powder 3.0 g, protein peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast infusion powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, and distilled water, supplemented to 1000 mL.

[0067] The polydimethylsiloxane in the present application is a mixture of: a viscosity of 1.0-3.0 cps at 25 DEG C, purchased from SLOK, model Sicare 2942; and a viscosity of 6 cps at 25 DEG C, purchased from Shin-Etsu Silicone International Trade (Shanghai) Co., Ltd., model KF-96A-6T, with a mixing ratio of 3:1.

[0068] The polymethylsilsesquioxane in the present application is purchased from SLOK, model Sicare 2115F.

[0069] The moisturizing cream of the present application does not cause skin dryness in an extremely dry environment. Glycerin, PEG-100 stearate, etc. added in conventional moisturizing creams can maintain good moisturizing effect in a relatively moist environment, but in an extremely dry air, they will adsorb water on the surface of the skin in reverse, thereby accelerating the drying of the skin. The conventional method is to use moisturizing cream skin care products to achieve moisturizing of the skin surface; however, cream skin care products are relatively greasy for oily or mixed skin, and can also cause the appearance of closed pores and acne.

[0070] Therefore, the present application, through research on the fermentation process of Cordyceps sinensis, through the selection of culture medium, the selection of strains, and the research on symbiotic fermentation, finds that the cordycepin in Cordyceps sinensis prepared by the present application is more esterified, thereby realizing liposoluble absorption, not only absorption on the surface of the skin, so as to achieve skin moisturizing in a deeper layer, and the addition of citrus peel in the fermentation of Cordyceps sinensis can stimulate the absorption of adenosine in Cordyceps sinensis, further restoring the skin barrier; in addition, the addition of cetostearyl alcohol ethylhexanoate, ordinary citrus medica vulgaris peel oil, and citrus tangerina peel oil, combined with polydimethylsiloxane of different molecular weights, realizes good moisturizing without too much greasy feeling; and in an extremely dry environment, the skin does not appear to dry out in reverse.

[0071] The present application will be further explained and described in combination with specific embodiments.

[0072] Example 1

[0073] The present embodiment provides a three-dimensional water-locking moisturizing cream, and the preparation raw materials of the moisturizing cream comprise, by mass fraction:

[0074] The A-phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetostearyl alcohol 1.2 parts, butyrospermum parkii butter 1 part, cetostearyl alcohol oleate 0.5 parts, sorbitan oleate 0.5 parts, polydimethylsiloxane 0.5 parts, squalane 0.5 parts, and tocopheryl acetate 0.2 parts;

[0075] B phase raw materials: water 30 parts, glycerin 5 parts, butanediol 1 part, betaine 0.5 part, carbomer 0.2 part, hydrogenated lecithin 0.11 part, disodium EDTA 0.11 part;

[0076] C phase raw materials: water 5 parts, arginine 0.22 part;

[0077] D phase raw materials: butanediol 1 part, octanohydroxamic acid 0.05 part;

[0078] E phase raw materials: water 5 parts, nicotinamide 0.11 part;

[0079] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 part;

[0080] G phase raw materials: water 30.69 parts, lauryl polydimethylsiloxane / polyglyceryl-3 crosslinked polymer 0.3 part, polymethylsilsesquioxane 0.3 part, caprylyl glycol 0.1 part, phenoxyethanol 0.1 part;

[0081] H phase raw materials: Cordyceps sinensis extract 1 part, 1,3-propanediol 0.1 part, 1,2-hexanediol 0.15 part, filtrate of Saccharomyces galactosus-like fungus fermentation product 1 part, p-hydroxyacetophenone 0.05 part, ethylhexylglycerin 0.1 part, Cynanchum atratum extract 0.05 part, Sophora angustifolia root extract 0.1 part, Gynostemma pentaphyllum extract 0.1 part, xylitol-based glucoside 0.1 part, anhydrous xylitol 0.1 part, xylitol 0.1 part, Prunus speciosa flower extract 0.4 part, malt oligosaccharide glucoside 0.1 part, hydrogenated starch hydrolysate 0.1 part, farnesol 0.11 part, isohexadecane 0.05 part, cetyl alcohol ethylhexanoate 0.1 part, common Citrus medica vulgaris peel oil 1.5 parts, Citrus tangerina peel oil 1 part;

[0082] I phase raw materials: water 0.1 part, Thermus thermophilus fermentation product 0.001 part, soluble collagen 0.001 part, butanediol 0.001 part, ethylhexylglycerin 0.001 part.

[0083] Among them, the preparation method of the Cordyceps sinensis extract is as follows:

[0084] (3) take Cordyceps sinensis washed and dried, grinding and sieving; the orange peel washed and dried, cut into small pieces;

[0085] (4) the Cordyceps sinensis powder and orange peel mixed and added to the culture solution, mixed evenly, then continue to inoculate the strain, inoculation amount is 10%, after aerobic fermentation at 28℃ for 72h, remove the filter residue, get Cordyceps sinensis extract.

[0086] The mass ratio of the Cordyceps sinensis powder and orange peel is 4:1.

[0087] The strain is Candida 32586 and Aspergillus 40048; the inoculation amount ratio is 3:2.

[0088] The composition of the culture solution comprises beef extract powder 3.0g, protein peptone 10.0g, tryptone (BBL) 5.0g, vegetable peptone 3.0g, yeast extract powder 5.0g, glucose 10.0g, soluble starch 0.5g, K2HPO4 1.0g, KH2PO4 1.0g, MgSO4·7H2O 0.2g, 5% L-cysteine hydrochloride solution 10.0mL, Tween 80 1.0g, and distilled water is added to 1000mL.

[0089] The preparation method of the common citron (CITRUS MEDICA VULGARIS) peel oil and tangerine (CITRUS TANGERINA) peel oil is as follows:

[0090] (1) the common citron (CITRUS MEDICA VULGARIS) peel and tangerine (CITRUS TANGERINA) peel are cut into small pieces and added to the culture solution, mixed evenly, then continue to inoculate the strain, inoculation amount is 8%, after aerobic fermentation at 28℃ for 72h, remove the filter residue, stand and take the oil layer to get the common citron (CITRUS MEDICA VULGARIS) peel oil and tangerine (CITRUS TANGERINA) peel oil.

[0091] The strain is Hanseniaspora uvarum and Aspergillus 1959; the inoculation amount ratio is 2:2.

[0092] ​The components of the culture solution include: beef extract powder 3.0g, peptone 10.0g, tryptone (BBL) 5.0g, vegetable peptone 3.0g, yeast extract powder 5.0g, glucose 10.0g, soluble starch 0.5g, K2HPO4 1.0g, KH2PO4 1.0g, MgSO4·7H2O 0.2g, 5% L-cysteine hydrochloride solution 10.0mL, Tween 80 1.0g, distilled water to 1000mL.

[0093] The polydimethylsiloxane in this example is a mixture of: viscosity 1.0-3.0cps 25℃, purchased from Slocam, model Sicare 2942; and viscosity 6cps 25℃, purchased from Shin-Etsu Silicone International Trade (Shanghai) Co., Ltd., model KF-96A-6T, with a mixing ratio of 3:1.

[0094] The polymethylsilsesquioxane in this example is purchased from Slocam, model Sicare 2115F.

[0095] The preparation method of the three-dimensional water-locked moisturizing cream is as follows:

[0096] S1. Do good cleaning work, strictly clean and disinfect the equipment and utensils;

[0097] S2. Put the A phase raw materials into the oil pot one by one, stir to warm up to 80-85℃, and keep warm for a period of time to ensure complete dissolution of the material, and standby;

[0098] S3. Put the B phase raw materials into the emulsifying pot one by one, stir to warm up to 85-90℃, and keep warm for a period of time to ensure complete dissolution of the material, then pour the A phase into the emulsifying pot, homogenize and stir evenly, add the C phase raw materials, homogenize and stir evenly, and then cool down;

[0099] S4. Cool down to 60-65℃, add the pre-dissolved D phase raw materials, stir evenly, and continue to cool down;

[0100] S5. Cool down to 40-45℃, add H, I phase and pre-dissolved E, F, G phase raw materials, and stir evenly;

[0101] S6. Send for inspection, after passing, discharge, and after passing the micro-inspection, pour the material into the filling machine for filling.

[0102] Example 2

[0103] The three-dimensional water-locked moisturizing cream provided in this example contains, by mass fraction, the following preparation raw materials:

[0104] A phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetyl stearyl alcohol 1.2 parts, butyrospermum parkii fruit butter 1 part, cetyl stearyl alcohol olivate 0.5 parts, sorbitan olivate 0.5 parts, dimethicone 0.5 parts, squalane 0.5 parts, tocopheryl acetate 0.2 parts;

[0105] B phase raw materials: water 30 parts, glycerin 5 parts, butylene glycol 1 part, betaine 0.5 parts, carbomer 0.2 parts, hydrogenated lecithin 0.11 parts, disodium EDTA 0.11 parts;

[0106] C phase raw materials: water 5 parts, arginine 0.22 parts;

[0107] D phase raw materials: butylene glycol 1 part, caprylhydroxamic acid 0.05 parts;

[0108] E phase raw materials: water 5 parts, nicotinamide 0.11 parts;

[0109] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 parts;

[0110] G phase raw materials: water 30.69 parts, lauryl dimethicone / polyglyceryl-3 crosspolymer 0.3 parts, polymethylsilsesquioxane 0.3 parts, caprylyl glycol 0.1 parts, phenoxyethanol 0.1 parts;

[0111] H phase raw materials: cordyceps sinensis extract 1 part, 1,3-propanediol 0.1 parts, 1,2-hexanediol 0.15 parts, galactofermentum yeast-like fungus fermentation product filtrate 1 part, p-hydroxyacetophenone 0.05 parts, ethylhexylglycerin 0.1 parts, cynanchum atratum extract 0.05 parts, sophora angustifolia root extract 0.1 parts, gynostemma pentaphyllum extract 0.1 parts, xylitol-based glucoside 0.1 parts, anhydrous xylitol 0.1 parts, xylitol 0.1 parts, prunus speciosa flower extract 0.4 parts, maltodextrin glucoside 0.1 parts, hydrogenated starch hydrolysate 0.1 parts, farnesol 0.11 parts, isohexadecane 0.05 parts, cetyl alcohol ethylhexanoate 0.1 parts, common citruses medica vulgaris pericarp oil 1.5 parts, tangerine citruses tangerina pericarp oil 1 part;

[0112] Phase I raw materials: water 0.1 parts, Thermus thermophilus fermentation product 0.001 parts, soluble collagen 0.001 parts, butanediol 0.001 parts, ethylhexylglycerin 0.001 parts.

[0113] The preparation method of the CORDYCEPS SINENSIS extract is as follows:

[0114] (1) After washing and drying CORDYCEPS SINENSIS, it is crushed and sieved;

[0115] (2) The CORDYCEPS SINENSIS powder is added to the culture solution and mixed uniformly, then the inoculum is continuously inoculated at 10%, and after aerobic fermentation at 28°C for 72h, the filter residue is removed by filtration to obtain the CORDYCEPS SINENSIS extract.

[0116] The inoculum is Candida 32586 and Aspergillus 40048, and the inoculum ratio is 3:2.

[0117] The composition of the culture solution comprises beef extract powder 3.0g, protein peptone 10.0g, tryptone (BBL) 5.0g, vegetable peptone 3.0g, yeast extract powder 5.0g, glucose 10.0g, soluble starch 0.5g, K2HPO4 1.0g, KH2PO4 1.0g, MgSO4·7H2O 0.2g, 5% L-cysteine hydrochloride solution 10.0mL, Tween 80 1.0g, and distilled water is added to 1000mL.

[0118] The preparation method of the CITRUS MEDICA VULGARIS and CITRUS TANGERINA peel oil is as follows:

[0119] (1) The CITRUS MEDICA VULGARIS and CITRUS TANGERINA peels are cut and added to the culture solution and mixed uniformly, then the inoculum is continuously inoculated at 8%, and after aerobic fermentation at 28°C for 72h, the filter residue is removed by filtration to obtain the CITRUS MEDICA VULGARIS and CITRUS TANGERINA peel oil.

[0120] The inoculum is Hanseniaspora uvarum 1959 and Aspergillus niger 40048, and the inoculum ratio is 3:2. ​40048; inoculation amount ratio 2:2.

[0121] The components of the culture solution include: beef extract powder 3.0 g, peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast extract powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, and distilled water added to 1000 mL.

[0122] The polydimethylsiloxane in this example is a mixture of: viscosity 1.0-3.0 cps at 25°C, purchased from Slocam, model Sicare 2942; and viscosity 6 cps at 25°C, purchased from Shin-Etsu Silicone International Trade (Shanghai) Co., Ltd., model KF-96A-6T, with a mixing ratio of 3:1.

[0123] The polymethylsilsesquioxane in this example is purchased from Slocam, model Sicare 2115F.

[0124] The preparation method of the three-dimensional water-locked moisturizing cream is as follows:

[0125] S1. Perform good hygiene and cleaning work, and strictly clean and disinfect the equipment and utensils;

[0126] S2. Put the A-phase raw materials into the oil pot one by one, stir to heat to 80-85°C, and keep for a period of time to ensure complete dissolution of the material, and reserve;

[0127] S3. Put the B-phase raw materials into the emulsifying pot one by one, stir to heat to 85-90°C, and keep for a period of time to ensure complete dissolution of the material, then pour the A-phase into the emulsifying pot, homogenize and stir evenly, add the C-phase raw materials, homogenize and stir evenly, and then cool down;

[0128] S4. Cool down to 60-65°C, add the pre-dissolved D-phase raw materials, and stir evenly, and continue to cool down;

[0129] S5. Cool down to 40-45°C, add the H and I phases and the pre-dissolved E, F and G phases, and stir evenly;

[0130] S6. After inspection, if qualified, discharge, and after micro-inspection, pour the material into the filling machine for filling.

[0131] Example 3

[0132] The three-dimensional water-locked moisturizing cream provided in this example contains, by mass fraction, the following preparation raw materials:

[0133] A phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetyl stearyl alcohol 1.2 parts, butyrospermum parkii fruit butter 1 part, cetyl stearyl alcohol olivate 0.5 parts, sorbitan olivate 0.5 parts, dimethicone 0.5 parts, squalane 0.5 parts, tocopheryl acetate 0.2 parts;

[0134] B phase raw materials: water 30 parts, glycerin 5 parts, butylene glycol 1 part, betaine 0.5 parts, carbomer 0.2 parts, hydrogenated lecithin 0.11 parts, disodium EDTA 0.11 parts;

[0135] C phase raw materials: water 5 parts, arginine 0.22 parts;

[0136] D phase raw materials: butylene glycol 1 part, caprylhydroxamic acid 0.05 parts;

[0137] E phase raw materials: water 5 parts, nicotinamide 0.11 parts;

[0138] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 parts;

[0139] G phase raw materials: water 30.69 parts, lauryl dimethicone / polyglyceryl-3 crosspolymer 0.3 parts, polymethylsilsesquioxane 0.3 parts, caprylyl glycol 0.1 parts, phenoxyethanol 0.1 parts;

[0140] H phase raw materials: cordyceps sinensis extract 1 part, 1,3-propanediol 0.1 part, 1,2-hexanediol 0.15 parts, lactobacillus ferment lysate 1 part, p-hydroxyacetophenone 0.05 parts, ethylhexylglycerin 0.1 parts, cynanchum atratum extract 0.05 parts, sophora angustifolia root extract 0.1 parts, gynostemma pentaphyllum extract 0.1 parts, xylitol-based glucoside 0.1 parts, anhydrous xylitol 0.1 parts, xylitol 0.1 parts, prunus speciosa flower extract 0.4 parts, maltodextrin glucoside 0.1 parts, hydrogenated starch hydrolysate 0.1 parts, farnesol 0.11 parts, isohexadecane 0.05 parts, cetyl alcohol ethylhexanoate 0.1 parts, common citron peel oil 1.5 parts, tangerine (citrus tangerina) peel oil 1 part;

[0141] Phase I raw materials: 0.1 parts of water, 0.001 parts of THERMUS THERMOPHILLUS fermentation product, 0.001 parts of soluble collagen, 0.001 parts of butanediol, and 0.001 parts of ethylhexylglycerin.

[0142] The CORDYCEPS SINENSIS extract is prepared by the following method:

[0143] (1) The CORDYCEPS SINENSIS is washed, dried, and then crushed and sieved; the citrus peel is washed, dried, and then cut into pieces;

[0144] (2) The CORDYCEPS SINENSIS powder and the citrus peel pieces are mixed and then added to a culture solution and mixed evenly, and then a strain is inoculated, with an inoculation amount of 10%, and after aerobic fermentation at 28°C for 72 hours, the filter residue is removed by filtration, and the CORDYCEPS SINENSIS extract is obtained.

[0145] The mass ratio of the CORDYCEPS SINENSIS powder to the citrus peel is 4:1.

[0146] The strain is Candida 32586.

[0147] The culture solution comprises beef extract powder 3.0 g, peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast extract powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, and distilled water, supplemented to 1000 mL.

[0148] The CITRUS MEDICA VULGARIS peel oil and the CITRUS TANGERINA peel oil are prepared by the following method:

[0149] (1) The CITRUS MEDICA VULGARIS peel and the CITRUS TANGERINA peel are cut into pieces and then added to a culture solution and mixed evenly, and then a strain is inoculated, with an inoculation amount of 8%, and after aerobic fermentation at 28°C for 72 hours, the filter residue is removed by filtration, and the CITRUS MEDICA VULGARIS peel oil and the CITRUS TANGERINA peel oil are obtained by taking the oil layer after standing.

[0150] The strain is Hanseniaspora uvarum. 1959 and Aspergillus niger 40048; inoculum ratio of 2:2.

[0151] The components of the culture solution include: beef extract powder 3.0 g, peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast extract powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, distilled water to 1000 mL.

[0152] The polydimethylsiloxane in this example is a mixture of: viscosity 1.0-3.0 cps at 25°C, purchased from Slocam, model Sicare 2942; and viscosity 6 cps at 25°C, purchased from Shin-Etsu Silicone International Trade (Shanghai) Co., Ltd., model KF-96A-6T, with a mixing ratio of 3:1.

[0153] The polymethylsilsesquioxane in this example is purchased from Slocam, model Sicare 2115F.

[0154] The preparation method of the three-dimensional water-locking moisturizing cream is as follows:

[0155] S1. Do good cleaning work, strictly clean and disinfect the equipment and utensils;

[0156] S2. Put the A-phase raw materials into the oil pot one by one, stir to warm up to 80-85°C, and keep warm for a period of time to ensure complete dissolution of the material, and standby;

[0157] S3. Put the B-phase raw materials into the emulsifying pot one by one, stir to warm up to 85-90°C, and keep warm for a period of time to ensure complete dissolution of the material, then pour the A-phase into the emulsifying pot, homogenize and stir evenly, add the C-phase raw materials, homogenize and stir evenly, and then cool down;

[0158] S4. Cool down to 60-65°C, add the pre-dissolved D-phase raw materials, stir thoroughly, and continue to cool down;

[0159] S5. Cool down to 40-45°C, add the H and I phases and the pre-dissolved E, F and G phases, stir thoroughly;

[0160] S6. Send for inspection, after passing, discharge, and after passing the micro-inspection, pour the material into the filling machine for filling.

[0161] Example 4

[0162] The present embodiment provides a three-dimensional water-locking moisturizing cream. The preparation raw materials of the moisturizing cream comprise, by mass fraction:

[0163] A phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetyl stearyl alcohol 1.2 parts, butyrospermum parkii fruit butter 1 part, cetyl stearyl alcohol oleate 0.5 parts, sorbitan oleate 0.5 parts, dimethicone 0.5 parts, squalane 0.5 parts, tocopheryl acetate 0.2 parts;

[0164] B phase raw materials: water 30 parts, glycerol 5 parts, butanediol 1 part, betaine 0.5 parts, carbomer 0.2 parts, hydrogenated lecithin 0.11 parts, disodium EDTA 0.11 parts;

[0165] C phase raw materials: water 5 parts, arginine 0.22 parts;

[0166] D phase raw materials: butanediol 1 part, caprylhydroxamic acid 0.05 parts;

[0167] E phase raw materials: water 5 parts, nicotinamide 0.11 parts;

[0168] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 parts;

[0169] G phase raw materials: water 30.69 parts, lauryl dimethicone / polyglyceryl-3 crosslinked polymer 0.3 parts, polymethylsilsesquioxane 0.3 parts, caprylyl glycol 0.1 parts, phenoxyethanol 0.1 parts;

[0170] H phase raw materials: cordyceps sinensis extract 1 part, 1,3-propanediol 0.1 parts, 1,2-hexanediol 0.15 parts, saccharomyces lactis ferment filtrate 1 part, p-hydroxyacetophenone 0.05 parts, ethylhexylglycerin 0.1 parts, cynanchum atratum extract 0.05 parts, sophora angustifolia root extract 0.1 parts, gynostemma pentaphyllum extract 0.1 parts, xylitol-based glucoside 0.1 parts, anhydrous xylitol 0.1 parts, xylitol 0.1 parts, prunus speciosa flower extract 0.4 parts, maltodextrin glucoside 0.1 parts, hydrogenated starch hydrolysate 0.1 parts, farnesol 0.11 parts, isohexadecane 0.05 parts, cetyl alcohol ethylhexanoate 0.1 parts, common citron peel oil 1.5 parts, tangerine (citrus tangerina) peel oil 1 part;

[0171] Phase I raw materials: water 0.1 parts, Thermus thermophilus fermentation product 0.001 parts, soluble collagen 0.001 parts, butanediol 0.001 parts, ethylhexylglycerin 0.001 parts.

[0172] The preparation method of the CORDYCEPS SINENSIS extract is as follows:

[0173] (1) After washing and drying Cordyceps sinensis, it is crushed and sieved; after washing and drying citrus peel, it is cut into pieces;

[0174] (2) The Cordyceps sinensis powder and the citrus peel pieces are mixed (the mass ratio of the Cordyceps sinensis powder to the citrus peel is 4:1), and an extract is obtained by water extraction, wherein the solid-liquid ratio is 1:10, the solvent is distilled water, the extraction temperature is 80°C, and the extraction time is 2 hours; after extraction, the filtrate is concentrated to obtain an extract with the same volume as that of Example 1.

[0175] The preparation method of the CITRUS MEDICA VULGARIS peel oil and the CITRUS TANGERINA peel oil is as follows:

[0176] (1) The CITRUS MEDICA VULGARIS peel and the CITRUS TANGERINA peel are cut into pieces and then added to a culture solution and mixed uniformly, and then a strain is inoculated, the inoculation amount is 8%, and after aerobic fermentation at 28°C for 72 hours, the filtrate is obtained by removing the filter residue, and then the oil layer is obtained by standing to obtain the CITRUS MEDICA VULGARIS peel oil and the CITRUS TANGERINA peel oil.

[0177] The strain is Hanseniaspora uvarum Henseniaspora uvarum 1959 and Aspergillus niger Aspergillus niger 40048. The inoculation amount ratio is 2:2.

[0178] The composition of the culture solution comprises beef infusion powder 3.0 g, peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast extract powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, and distilled water is added to 1000 mL.

[0179] ​The polydimethylsiloxane in this embodiment is a mixture of: a viscosity of 1.0-3.0 cps at 25°C, purchased from SLOK, model Sicare 2942; and a viscosity of 6 cps at 25°C, purchased from Shin-Etsu Silicone International Trade (Shanghai) Co., Ltd., model KF-96A-6T, with a mixing ratio of 3:1.

[0180] The polymethylsilsesquioxane in this embodiment is purchased from SLOK, model Sicare 2115F.

[0181] The preparation method of the three-dimensional water-locked moisturizing cream is as follows:

[0182] S1. Clean the equipment and utensils thoroughly and disinfect them strictly;

[0183] S2. Put the A-phase raw materials into the oil pot one by one, stir and heat to 80-85°C, and keep the temperature for a period of time to ensure that the material is completely dissolved, and then prepare for use;

[0184] S3. Put the B-phase raw materials into the emulsifying pot one by one, stir and heat to 85-90°C, and keep the temperature for a period of time to ensure that the material is completely dissolved, then pour the A-phase into the emulsifying pot, homogenize and stir evenly, add the C-phase raw materials, homogenize and stir evenly, and then cool down;

[0185] S4. Cool down to 60-65°C, add the pre-dissolved D-phase raw materials, stir thoroughly, and continue to cool down;

[0186] S5. Cool down to 40-45°C, add the H and I phases and the pre-dissolved E, F and G phases, stir thoroughly;

[0187] S6. After inspection and approval, discharge the material, pour it into the filling machine for filling, and it is ready.

[0188] Example 5

[0189] The three-dimensional water-locked moisturizing cream provided in this embodiment is prepared from the following raw materials by mass:

[0190] A-phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetyl stearyl alcohol 1.2 parts, butyrospermum parkii butter 1 part, cetyl stearyl alcohol oleate 0.5 parts, sorbitan oleate 0.5 parts, dimethicone 0.5 parts, squalane 0.5 parts, tocopheryl acetate 0.2 parts;

[0191] B-phase raw materials: water 30 parts, glycerol 5 parts, butylene glycol 1 part, betaine 0.5 parts, carbomer 0.2 parts, hydrogenated lecithin 0.11 parts, disodium EDTA 0.11 parts;

[0192] C phase raw materials: water 5 parts, arginine 0.22 parts;

[0193] D phase raw materials: butanediol 1 part, octanoyl hydroxamic acid 0.05 parts;

[0194] E phase raw materials: water 5 parts, nicotinamide 0.11 parts;

[0195] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 parts;

[0196] G phase raw materials: water 30.69 parts, lauryl polydimethylsiloxane / polyglycerin-3 cross-linked polymer 0.3 parts, polymethylsilsesquioxane 0.3 parts, caprylyl glycol 0.1 parts, phenoxyethanol 0.1 parts;

[0197] H phase raw materials: Cordyceps sinensis extract 1 part, 1,3-propanediol 0.1 part, 1,2-hexanediol 0.15 part, Saccharomyces galactose yeast-like fungus fermentation filtrate 1 part, p-hydroxyacetophenone 0.05 part, ethylhexylglycerin 0.1 part, Cynanchum atratum extract 0.05 part, Sophora angustifolia root extract 0.1 part, Gynostemma pentaphyllum extract 0.1 part, xylitol-based glucoside 0.1 part, anhydrous xylitol 0.1 part, xylitol 0.1 part, Prunus speciosa flower extract 0.4 part, malt oligosaccharide glucoside 0.1 part, hydrogenated starch hydrolysate 0.1 part, bisabalol 0.11 part, isohexadecane 0.05 part, cetyl alcohol ethylhexanoate 0.1 part, common citron (Citrus medica vulgaris) peel oil 1.5 parts, tangerine (Citrus tangerina) peel oil 1 part;

[0198] I phase raw materials: water 0.1 parts, Thermus thermophilus fermentation product 0.001 parts, soluble collagen 0.001 parts, butanediol 0.001 parts, ethylhexylglycerin 0.001 parts.

[0199] The preparation method of the Cordyceps sinensis extract is as follows:

[0200] (5) Take Cordyceps sinensis, wash and dry, then crush and sieve; wash and dry the citrus peel, then cut it into pieces;

[0201] (6) The Cordyceps sinensis powder and the citrus peel pieces are mixed and then added into the culture solution, and then the strain is inoculated, and the inoculation amount is 10%. After aerobic fermentation at 28°C for 72h, the filtrate is obtained by removing the filter residue, and the Cordyceps sinensis extract is obtained.

[0202] The strain is Candida 32586 and Aspergillus 40048, and the inoculation amount ratio is 3:2.

[0203] The culture solution comprises beef extract powder 3.0g, protein peptone 10.0g, tryptone (BBL) 5.0g, vegetable peptone 3.0g, yeast extract powder 5.0g, glucose 10.0g, soluble starch 0.5g, K2HPO4 1.0g, KH2PO4 1.0g, MgSO4·7H2O 0.2g, 5% L-cysteine hydrochloride solution 10.0mL, Tween 80 1.0g, and distilled water is added to 1000mL.

[0204] The preparation method of the Citrus medica vulgaris peel oil and the Citrus tangerina peel oil is as follows:

[0205] (1) The Citrus medica vulgaris peel and the Citrus tangerina peel are cut into pieces and then added into the culture solution, and then the strain is inoculated, and the inoculation amount is 8%. After aerobic fermentation at 28°C for 72h, the filtrate is obtained by removing the filter residue, and the oil layer is obtained by standing, and the Citrus medica vulgaris peel oil and the Citrus tangerina peel oil are obtained.

[0206] The strain is Hanseniaspora uvarum 1959 and Aspergillus 40048, and the inoculation amount ratio is 2:2.

[0207] The culture solution comprises beef extract powder 3.0g, protein peptone 10.0g, tryptone (BBL) 5.0g, vegetable peptone 3.0g, yeast extract powder 5.0g, glucose 10.0g, soluble starch 0.5g, K2HPO4 1.0g, KH2PO4 1.0g, MgSO4·7H2O 0.2g, 5% L-cysteine hydrochloride solution 10.0mL, Tween 80 1.0g, and distilled water is added to 1000mL.

[0208] The polydimethylsiloxane in the present application is: viscosity 1.0-3.0 cps 25℃, purchased from Slocos, model Sicare 2942.

[0209] The polymethylsilsesquioxane in the present application is purchased from Slocos, model Sicare 2113.

[0210] The preparation method of the three-dimensional water-locked moisturizing cream is as follows:

[0211] S1. Do good cleaning work, strictly clean and disinfect the equipment and utensils;

[0212] S2. Put the A phase raw materials into the oil pot in turn, stir and heat to 80-85℃, keep for a period of time to ensure complete dissolution of the material, and reserve;

[0213] S3. Put the B phase raw materials into the emulsifying pot in turn, stir and heat to 85-90℃, keep for a period of time to ensure complete dissolution of the material, then pour the A phase into the emulsifying pot, homogenize and stir evenly, add the C phase raw materials, homogenize and stir evenly, and then cool down;

[0214] S4. Cool down to 60-65℃, add the pre-dissolved D phase raw materials, stir evenly, and continue to cool down;

[0215] S5. Cool down to 40-45℃, add H, I phase and pre-dissolved E, F, G phase raw materials, and stir evenly;

[0216] S6. Send for inspection, after passing, discharge, and after passing the micro-inspection, pour the material into the filling machine for filling.

[0217] Example 6

[0218] The present embodiment provides a three-dimensional water-locked moisturizing cream, according to mass parts, the preparation raw materials of the moisturizing cream contain:

[0219] A phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetylstearyl alcohol 1.2 parts, butyrospermum parkii butter 1 part, cetylstearyl alcohol oleate 0.5 parts, sorbitan oleate 0.5 parts, dimethicone 0.5 parts, squalane 0.5 parts, tocopheryl acetate 0.2 parts;

[0220] B phase raw materials: water 30 parts, glycerol 5 parts, butanediol 1 part, betaine 0.5 parts, carbomer 0.2 parts, hydrogenated lecithin 0.11 parts, disodium EDTA 0.11 parts;

[0221] C phase raw materials: water 5 parts, arginine 0.22 parts;

[0222] D phase raw materials: butanediol 1 part, octanoyl hydroxamic acid 0.05 parts;

[0223] E phase raw materials: water 5 parts, nicotinamide 0.11 parts;

[0224] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 parts;

[0225] G phase raw materials: water 30.69 parts, lauryl polydimethylsiloxane / polyglycerin-3 cross-linked polymer 0.3 parts, polymethylsilsesquioxane 0.3 parts, caprylyl glycol 0.1 parts, phenoxyethanol 0.1 parts;

[0226] H phase raw materials: Cordyceps sinensis extract 1 part, 1,3-propanediol 0.1 part, 1,2-hexanediol 0.15 part, filtrate of Saccharomyces galactosus-like fungus fermentation product 1 part, p-hydroxyacetophenone 0.05 part, ethylhexylglycerin 0.1 part, Cynanchum atratum extract 0.05 part, Sophora angustifolia root extract 0.1 part, Gynostemma pentaphyllum extract 0.1 part, xylitol-based glucoside 0.1 part, anhydrous xylitol 0.1 part, xylitol 0.1 part, Prunus speciosa flower extract 0.4 part, maltodextrin glucoside 0.1 part, hydrogenated starch hydrolysate 0.1 part, bisabalol 0.11 part, isohexadecane 0.05 part, cetyl alcohol ethylhexanoate 2.6 parts;

[0227] I phase raw materials: water 0.1 part, Thermus thermophilus fermentation product 0.001 part, soluble collagen 0.001 part, butanediol 0.001 part, ethylhexylglycerin 0.001 part.

[0228] The preparation method of the Cordyceps sinensis extract is as follows:

[0229] (7) After washing and drying Cordyceps sinensis, it is crushed and sieved; after washing and drying citrus peels, it is cut into pieces;

[0230] (8) After mixing the Cordyceps sinensis powder and the citrus peel pieces (mass ratio 4:1), they are added to the culture solution and mixed uniformly, then the inoculum is continuously inoculated, the inoculum amount is 10%, after aerobic fermentation at 28°C for 72h, the filter residue is removed, and the Cordyceps sinensis extract is obtained.

[0231] The bacteria are Candida rugosa, Candida 32586 and Aspergillus niger 40048; inoculation ratio is 3:2.

[0232] The composition of the culture solution comprises beef extract powder 3.0 g, peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast extract powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, and distilled water is supplemented to 1000 mL.

[0233] The polydimethylsiloxane in this example is a mixture of Sicare 2942 (viscosity 1.0-3.0 cps at 25℃, purchased from SLOKOS) and KF-96A-6T (viscosity 6 cps at 25℃, purchased from SHIN-ETU ORGANIC SILICON INTERNATIONAL TRADE (SHANGHAI) CO., LTD.), with a mixing ratio of 3:1.

[0234] The polymethylsilsesquioxane in this example is purchased from SLOKOS, with a model number of Sicare 2115F.

[0235] The preparation method of the three-dimensional water-locking moisturizing cream comprises the following steps:

[0236] S1. Perform good sanitary cleaning work, and strictly clean and disinfect the equipment and utensils;

[0237] S2. Put the A-phase raw materials into an oil pot in sequence, stir to heat to 80-85℃, and keep the temperature for a period of time to ensure complete dissolution of the material, and reserve;

[0238] S3. Put the B-phase raw materials into an emulsifying pot in sequence, stir to heat to 85-90℃, and keep the temperature for a period of time to ensure complete dissolution of the material, then pour the A-phase into the emulsifying pot, homogenize and stir uniformly, add the C-phase raw materials, homogenize and stir uniformly, and then cool down;

[0239] S4. Cool down to 60-65℃, add the pre-dissolved D-phase raw materials, and fully stir uniformly, and continue to cool down;

[0240] S5. Cool down to 40-45℃, add the H and I phases and the pre-dissolved E, F and G phases, and fully stir uniformly;

[0241] S6. Perform inspection, and after passing the inspection, discharge the material, pour the material into a filling machine for filling after passing the micro-inspection, and then the process is completed.

[0242] Example 7

[0243] The present embodiment provides a three-dimensional water-locking moisturizing cream. The preparation raw materials of the moisturizing cream comprise, by mass:

[0244] A phase raw materials: isononyl isononanoate 5 parts, PEG-100 stearate 0.5 parts, glyceryl stearate 1 part, cetyl stearyl alcohol 1.2 parts, butyrospermum parkii fruit butter 1 part, cetyl stearyl alcohol oleate 0.5 parts, sorbitan oleate 0.5 parts, dimethicone 0.5 parts, squalane 0.5 parts, tocopheryl acetate 0.2 parts;

[0245] B phase raw materials: water 30 parts, glycerin 5 parts, butylene glycol 1 part, betaine 0.5 parts, carbomer 0.2 parts, hydrogenated lecithin 0.11 parts, disodium EDTA 0.11 parts;

[0246] C phase raw materials: water 5 parts, arginine 0.22 parts;

[0247] D phase raw materials: butylene glycol 1 part, caprylhydroxamic acid 0.05 parts;

[0248] E phase raw materials: water 5 parts, nicotinamide 0.11 parts;

[0249] F phase raw materials: water 5 parts, tetrahydro methyl pyrimidine carboxylic acid 0.11 parts;

[0250] G phase raw materials: water 30.69 parts, lauryl dimethicone / polyglyceryl-3 crosslinked polymer 0.3 parts, polymethylsilsesquioxane 0.3 parts, caprylyl glycol 0.1 parts, phenoxyethanol 0.1 parts;

[0251] H phase raw materials: cordyceps sinensis extract 1 part, citrus peel extract 0.25 parts, 1,3-propanediol 0.1 parts, 1,2-hexanediol 0.15 parts, saccharomyces lactis ferment filtrate 1 part, p-hydroxyacetophenone 0.05 parts, ethylhexylglycerin 0.1 parts, cynanchum atratum extract 0.05 parts, sophora angustifolia root extract 0.1 parts, gynostemma pentaphyllum extract 0.1 parts, xylitol-based glucoside 0.1 parts, anhydrous xylitol 0.1 parts, xylitol 0.1 parts, prunus speciosa flower extract 0.4 parts, maltodextrin glucoside 0.1 parts, hydrogenated starch hydrolysate 0.1 parts, farnesol 0.11 parts, isohexadecane 0.05 parts, cetyl alcohol ethylhexanoate 0.1 parts, common citron (citrus medica vulgaris) peel oil 1.5 parts, citrus tangerina peel oil 1 part;

[0252] I phase raw materials: water 0.1 parts, Thermus thermophilus (THERMUS THERMOPHILLUS) fermentation product 0.001 parts, soluble collagen 0.001 parts, butanediol 0.001 parts, ethylhexyl glycerin 0.001 parts.

[0253] The preparation method of the CORDYCEPS SINENSIS extract is as follows:

[0254] (1) After washing and drying CORDYCEPS SINENSIS, it is crushed and sieved; (2) The CORDYCEPS SINENSIS powder is added to the culture solution and mixed uniformly, and then the inoculum is continuously inoculated, the inoculation amount is 8%, after aerobic fermentation at 28°C for 72h, the filter residue is removed, and the CORDYCEPS SINENSIS extract is obtained.

[0255] The inoculum is Candida rugosa 32586 and Aspergillus niger 40048, and the inoculation ratio is 3:2. The inoculum is Candida rugosa 32586 and Aspergillus niger 40048, and the inoculation ratio is 3:2.

[0256] The composition of the culture solution comprises beef extract powder 3.0g, protein peptone 10.0g, tryptone (BBL) 5.0g, vegetable peptone 3.0g, yeast extract powder 5.0g, glucose 10.0g, soluble starch 0.5g, K2HPO4 1.0g, KH2PO4 1.0g, MgSO4·7H2O 0.2g, 5% L-cysteine hydrochloride solution 10.0mL, Tween 80 1.0g, and distilled water is supplemented to 1000mL.

[0257] The preparation method of the citrus peel extract is as follows:

[0258] (1) After washing and drying the citrus peel, it is cut into pieces;

[0259] (2) The citrus peel pieces are added to the culture solution and mixed uniformly, and then the inoculum is continuously inoculated, the inoculation amount is 2%, after aerobic fermentation at 28°C for 72h, the filter residue is removed, and the citrus peel extract is obtained.

[0260] The inoculum is Candida rugosa 32586 and Aspergillus niger 40048, and the inoculation ratio is 3:2. The inoculum is Candida rugosa 32586 and Aspergillus niger 40048, and the inoculation ratio is 3:2.

[0261] ​​The components of the culture solution include: beef infusion powder 3.0 g, peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast extract powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, and distilled water added to 1000 mL.

[0262] The preparation method of the common citron (CITRUS MEDICA VULGARIS) peel oil and tangerine (CITRUS TANGERINA) peel oil is as follows:

[0263] (1) The common citron (CITRUS MEDICA VULGARIS) peel and tangerine (CITRUS TANGERINA) peel are cut and then added to the culture solution and mixed uniformly, and then the strain is inoculated, the inoculation amount is 8%, after aerobic fermentation at 28°C for 72 h, the filter residue is removed, and then the oil layer is taken after standing to obtain the common citron (CITRUS MEDICA VULGARIS) peel oil and tangerine (CITRUS TANGERINA) peel oil.

[0264] The strain is grape juice spore Hanseniaspora uvarum and Aspergillus niger. 1959 and Aspergillus niger. 40048; the inoculation amount ratio is 2:2.

[0265] The components of the culture solution include: beef infusion powder 3.0 g, peptone 10.0 g, tryptone (BBL) 5.0 g, vegetable peptone 3.0 g, yeast extract powder 5.0 g, glucose 10.0 g, soluble starch 0.5 g, K2HPO4 1.0 g, KH2PO4 1.0 g, MgSO4·7H2O 0.2 g, 5% L-cysteine hydrochloride solution 10.0 mL, Tween 80 1.0 g, and distilled water added to 1000 mL.

[0266] The polydimethylsiloxane in this example is a mixture of: viscosity 1.0-3.0 cps 25°C, purchased from Slocam, model Sicare 2942; and viscosity 6 cps 25°C, purchased from Shin-Etsu Silicone International Trade (Shanghai) Co., Ltd., model KF-96A-6T, with a mixing ratio of 3:1.

[0267] The polymethylsilsesquioxane in this example is purchased from Slocam, model Sicare 2115F.

[0268] The preparation method of the three-dimensional water-locking moisturizing cream is as follows:

[0269] S1. Do good hygiene and cleaning work, and strictly clean and disinfect the equipment and utensils;

[0270] S2. Put the A-phase raw materials into the oil pot one by one, stir and heat to 80-85°C, and keep for a period of time to ensure complete dissolution of the material, and standby;

[0271] S3. Put the B-phase raw materials into the emulsifying pot one by one, stir and heat to 85-90°C, and keep for a period of time to ensure complete dissolution of the material, then pour the A-phase into the emulsifying pot, homogenize and stir evenly, add the C-phase raw materials, homogenize and stir evenly, and then cool down;

[0272] S4. Cool down to 60-65°C, add the pre-dissolved D-phase raw materials, and stir evenly, and continue to cool down;

[0273] S5. Cool down to 40-45°C, add the H and I phases and the pre-dissolved E, F and G phases, and stir evenly;

[0274] S6. Send for inspection, and after passing, discharge, and after passing the micro-inspection, pour the material into the filling machine for filling.

[0275] Performance test

[0276] Test 1: Place moisturizing creams 1-7 at 5°C, 25°C and 40°C respectively, and stand for 90 days, and observe the properties. Perform cold and hot cycle test. The cold and hot cycle stability: 2 days for one cycle, the first day is placed in a -18°C constant temperature box, and the second day is placed in a 48°C constant temperature box. After recovery to room temperature, observe whether the appearance of the solution changes, whether there are phenomena such as stratification, precipitation, emulsification and turbidity, etc. Test for 8 days, and the test results are shown in Table 1.

[0277] Table 1 Test results of Test 1

[0278] Example 5℃ 25℃ 40℃ Example 1 No change in properties No change in properties No change in properties Example 2 Slight delamination No change in properties Slight delamination Example 3 No change in properties No change in properties No change in properties Example 4 Slight delamination No change in properties Slight delamination Example 5 No change in properties No change in properties No change in properties Example 6 No change in properties No change in properties No change in properties Example 7 Slight delamination No change in properties Slight delamination

[0279] Test 2: Moisturizing test

[0280] 32 people were actually included, 7 men and 25 women, aged 30 to 50, with an average of 32.50±1.45 years, and the test area was the face. The test environment was 21±1°C and 50±10% RH.

[0281] One week before the test, the subjects stopped using facial cosmetics or external drugs. The night before the test, the subjects washed their faces at home and did not apply any skin care products. On the morning of the test, the subjects washed their faces at home with clean water and did not apply any skin care products. The subjects who passed the screening filled out the informed consent form. After the subjects cleaned their faces with clean water, they rested in a constant temperature and humidity room (temperature 21±1℃, relative humidity 50±10%RH) for 30 minutes. During the test, the subjects did not use any other products (the subjects used the relevant products in the morning and evening, and the relevant tests were conducted after 18h and 7d of use).

[0282] Stratum corneum moisture content:

[0283] Test site: cheek skin

[0284] Test instrument: Courage + Khazaka skin moisture tester Corneometer CM825

[0285] Table 2 Stratum corneum moisture content test

[0286]

[0287] Average improvement rate = (average after use - average before use) / (average before use) * 100%

[0288] Test 3: difference in transepidermal water loss rate

[0289] 25-60 year-old healthy subjects (all subjects had the characteristics of sensitive skin, such as easy allergy, redness, etc.), 6 males and 23 females, with an average age of 40.13±3.42 years.

[0290] Use site: forearm

[0291] Method of use: when used on the forearm, the test sample was applied in an amount of (2.0±0.1) mg / cm 2 , and a latex glove was used to evenly spread the sample over the test area.

[0292] Test steps

[0293] The subjects did not touch the inside of the arm before the visit

[0294] Before the experiment, the subjects cleaned their arms with dry paper towels;

[0295] Mark 2 measurement areas on the inside of the subject's left or right arm, each area being 3cm*3cm in size, with a distance of at least 1cm between the areas;

[0296] The sample area and the negative control area are randomly distributed in the calibration area, ensuring that each area position is statistically balanced: the subject exposes the arm, in an environment at a temperature of 21 ± 1 °C and a relative humidity of 40 ± 10% RH, for 30 minutes; the sample area and the negative area are applied with the inducer (0.1% histamine solution) for 10 minutes, at the end of the application, before using the sample (Timm), the transepidermal water loss rate of the calibration area is tested with the Tewameter and the hemoglobin of the calibration area is tested with the Mexameter.

[0297] After the sample, the subject exposes the arm, in an environment at a temperature of 21 ± 1 °C and a relative humidity of 40 ± 10% RH; after 1 hour (T1), the transepidermal water loss rate of the calibration area is tested with the Tewameter; after 1 hour (T1), the hemoglobin of the calibration area is tested with the Mexameter.

[0298] Courage + Khazaka percutaneous water loss and water evaporation heat loss test probe Tewameter TM300 for detecting the transepidermal water loss rate of the skin.

[0299] Table 3 transepidermal water loss rate before and after comparison

[0300]

[0301]

[0302] Courage + Khazaka skin melanin and hemoglobin tester Mexameter MX18 for detecting the hemoglobin of the skin.

[0303] Table 4 hemoglobin before and after comparison

[0304] Example Before (mean ± standard deviation) After 1 h (mean ± standard deviation) Example 1 352.64±43.28 191.32±38.31 Example 2 352.32±25.31 205.21±32.18 Example 3 352.75±15.28 207.56±28.57 Example 4 352.19±32.38 208.49±32.93 Example 5 352.52±26.56 201.26±42.28 Example 6 353.02±30.21 200.16±41.31 Example 7 352.61±31.43 202.52±32.18 Negative area 353.12±27.12 331.24±32.32

[0305] Test 4: Human trial comprehensive evaluation experiment: the human subjects of this test are the same as those of test 3, after the sample, the subject exposes the arm, in an environment at a temperature of 21 ± 1 °C and a relative humidity of 15 ± 5% RH, and experiences the product, and scores are made during the experience period.

[0306] Table 5 use feeling score table

[0307] No. Question Score 1 The sample was used gently and was not irritating; □5□4□3□2□1 2 After use, the sample was felt to improve dryness, to moisturize the skin; □5□4□3□2□1 3 After use, the sample was felt to have a moisturizing effect after use; □5□4□3□2□1 4 After use, the sample was felt to repair the skin; □5□4□3□2□1 5 Overall, I was satisfied with the sample. □5□4□3□2□1

[0308] 5 points represent complete agreement, 4 points represent relatively agreement, 3 points represent both agreement and disagreement, 2 points represent relatively disagreement, and 1 point represents complete disagreement. A total of 29 people, the total number of records is shown in Table 6.

[0309] Table 6 test results of test 4

[0310] Example Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Question 1 145 144 145 144 145 145 145 Question 2 143 136 140 133 130 129 138 Question 3 142 134 139 132 128 128 137 Question 4 140 122 121 118 130 132 127 Question 5 141 136 138 132 131 129 137

[0311] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, and are not intended to limit the present application; although the present application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that the technical solutions described in the foregoing embodiments can still be modified, or some or all of the technical features can be replaced by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A three-dimensional moisturizing lotion, characterized in that, According to parts by weight, the raw materials for preparing the moisturizing lotion include: Phase A raw materials: 5 parts isononyl isononanoate, 0.5 parts PEG-100 stearate, 1 part glyceryl stearate, 1.2 parts cetearyl alcohol, 1 part Butyrospermum Parkii fruit butter, 0.5 parts cetearyl alcohol oleate, 0.5 parts sorbitan oleate, 0.5 parts polydimethylsiloxane, 0.5 parts squalane, 0.2 parts tocopheryl acetate; Phase B ingredients: 30 parts water, 5 parts glycerin, 1 part butylene glycol, 0.5 parts betaine, 0.2 parts carbomer, 0.11 parts hydrogenated lecithin, 0.11 parts disodium EDTA; Phase C raw materials: 5 parts water, 0.22 parts arginine; D-phase raw materials: 1 part butanediol, 0.05 parts octanoyl hydroxamic acid; E-phase raw materials: 5 parts water, 0.11 parts nicotinamide; F-phase raw materials: 5 parts water, 0.11 parts tetrahydromethylpyrimidine carboxylic acid; G-phase raw materials: 30.69 parts water, 0.3 parts lauryl polydimethylsiloxane / polyglycerol-3 crosspolymer, 0.3 parts polymethylsilsesquioxane, 0.1 parts octyl glycol, 0.1 parts phenoxyethanol; Phase H raw materials: 1 part Cordyceps sinensis extract, 0.1 part 1,3-propanediol, 0.15 part 1,2-hexanediol, 1 part galactosomal yeast fermentation product filtrate, 0.05 part p-hydroxyacetophenone, 0.1 part ethylhexylglycerin, 0.05 part Cynanchum atratum extract, 0.1 part Sophora angustifolia root extract, 0.1 part Gynostemma pentaphyllum extract, 0.1 part xylitol glucoside, 0.1 part dehydrated xylitol, 0.1 part xylitol, 0.1 part prawn (cherry blossom) SPECIOSA flower extract 0.4 parts, malt oligosaccharide glucoside 0.1 parts, hydrogenated starch hydrolysate 0.1 parts, bisabolol 0.11 parts, isohexadecane 0.05 parts, cetyl ethylhexanoate 0.1 parts, common citron (CITRUS MEDICA VULGARIS) peel oil 1.5 parts, and large mandarin orange (CITRUS TANGERINA) peel oil 1 part; Phase I raw materials: 0.1 parts water, 0.001 parts Thermophilic thermophilic bacteria fermentation product, 0.001 parts soluble collagen, 0.001 parts butylene glycol, 0.001 parts ethylhexylglycerin; The preparation method of the Cordyceps sinensis extract is as follows: (1) Take Cordyceps sinensis, wash and dry it, then crush and sieve it; wash and dry the citrus peel, then chop it. (2) After mixing Cordyceps sinensis powder and citrus peel fragments, add them to the culture medium and mix evenly. Then, continue to inoculate with fungi at an inoculation rate of 10%. After aerobic fermentation at 28°C for 72 hours, filter to remove the residue and obtain Cordyceps sinensis extract. The mass ratio of the Cordyceps sinensis powder to the citrus peel is 4:

1. The strains mentioned are Candida rugosa CICC®32586 and Aspergillus niger CICC®40048; the inoculum ratio is 3:

2. The culture medium consists of: 3.0 g beef extract powder, 10.0 g peptone, 5.0 g tryptone BBL, 3.0 g plant peptone, 5.0 g yeast extract powder, 10.0 g glucose, 0.5 g soluble starch, 1.0 g K2HPO4, 1.0 g KH2PO4, 0.2 g MgSO4·7H2O, 10.0 mL 5% L-cysteine ​​hydrochloride solution, 1.0 g Tween 80, and distilled water to a final volume of 1000 mL. The preparation methods for the common citron (CITRUS MEDICA VULGARIS) peel oil and the large red mandarin orange (CITRUS TANGERINA) peel oil are as follows: (1) After chopping the peels of common citron (CITRUS MEDICA VULGARIS) and tangerine (CITRUS TANGERINA), add them to the culture medium and mix evenly. Then, continue to inoculate with bacteria at an inoculation rate of 8%. After aerobic fermentation at 28°C for 72 hours, filter to remove the residue, and let stand to collect the oil layer to obtain the common citron (CITRUS MEDICA VULGARIS) peel oil and tangerine (CITRUS TANGERINA) peel oil. The strains mentioned are *Hanseniaspora uvarum* CICC® 1959 and *Aspergillus niger* CICC® 40048; the inoculum ratio is 2:

2. The culture medium consists of: 3.0 g beef extract powder, 10.0 g peptone, 5.0 g tryptone BBL, 3.0 g plant peptone, 5.0 g yeast extract powder, 10.0 g glucose, 0.5 g soluble starch, 1.0 g K2HPO4, 1.0 g KH2PO4, 0.2 g MgSO4·7H2O, 10.0 mL 5% L-cysteine ​​hydrochloride solution, 1.0 g Tween 80, and distilled water to a final volume of 1000 mL. The polydimethylsiloxane is: a mixture of 1.0-3.0 cps at 25°C and a 6 cps at 25°C, with a mixing ratio of 3:

1.

2. The method for preparing a three-dimensional moisturizing emulsion according to claim 1, characterized in that, The steps are as follows: S1. Ensure proper hygiene and cleaning, and thoroughly clean and disinfect equipment and utensils; S2. Add the A phase raw material into the oil pot in sequence, stir and heat to 80-85℃, keep it at this temperature for a period of time to ensure that the material is completely dissolved, and set aside for later use; S3. Add phase B raw material to the emulsification pot in sequence, stir and heat to 85-90℃, keep warm for a period of time to ensure that the material is completely dissolved, then pump phase A into the emulsification pot, stir homogenously until uniform, add phase C raw material, stir homogenously until uniform, and then cool down. S4. Cool down to 60-65℃, add the pre-dissolved D-phase raw material, stir thoroughly and continue cooling; S5. Cool to 40-45℃, add H, I phase and pre-dissolved E, F and G phase raw materials, and stir thoroughly until homogeneous; S6. After inspection and approval, discharge the material. After micro-inspection and approval, pour the material into the filling machine for filling.

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