Adult incontinence dermatitis prevention and treatment ointment and preparation method thereof

Abstract

The invention discloses an adult incontinence dermatitis prevention and treatment ointment and a preparation method thereof, and the adult incontinence dermatitis prevention and treatment ointment comprises the following components by mass: 15%-25% of zinc oxide, 10%-20% of egg oil, 0.8%-2% of borneol, and 53%-74.2% of vaseline. The ointment disclosed by the invention is a product for preventing and treating incontinent dermatitis of adult incontinence patients. The components contained in the product are mild in property, can effectively prevent urine, excrement and other pollutants from irritating the skin of incontinence patients, and have the effects of moistening and protecting the skin and promoting skin wound healing.

Description

Technical Field

[0001] The present invention relates to the field of traditional medical technologies, and particularly relates to an ointment for preventing and treating adult incontinence dermatitis and a preparation method thereof. Background Art

[0002] Incontinence dermatitis is commonly found on the skin of the perineum, buttocks, inner thighs and other parts of elderly, weak or critically ill patients. The dermatitis can cause the skin to turn red and swell, with flaky spots or papules appearing, and may be accompanied by itching or pain. In severe cases, the skin will break and become infected. Incontinence dermatitis is a very painful thing for patients. In the case where incontinence cannot be effectively treated and improved, it is very difficult to prevent and care for this kind of dermatitis. Currently, in clinical practice, prevention of incontinence dermatitis is the main focus. Once the skin is damaged, symptomatic treatment is generally chosen.

[0003] Methods for preventing incontinence dermatitis include: 1. Skin cleaning and care: Using mild and non-irritating cleaning products to clean the skin. This method is the main nursing measure for incontinent patients. It can slow down local skin damage as much as possible and increase patient comfort. The urea in urine decomposes to produce ammonia, which will destroy the acidic environment of the skin, and the feces contain digestive enzymes that will damage the skin cutin layer and increase the risk of infection. 2. Isolating and protecting the skin: Applying a skin protectant to form a protective film to reduce the irritation of urine and feces. This method can effectively prevent incontinence dermatitis, but it has no promoting effect on the already infected skin and needs to be combined with anti-inflammatory drugs, increasing the nursing difficulty.

[0004] Methods for treating incontinence dermatitis include: 1. Cleaning and soothing the skin: Washing the affected skin with warm water and using a soothing lotion containing ingredients such as aloe to relieve skin inflammation and discomfort. This method is effective for patients with transient incontinence, but for elderly disabled or critically ill patients with long-term incontinence, frequent cleaning may cause mechanical damage, and it is difficult for the soothing lotion to prevent the occurrence of dermatitis. 2. Symptomatic drug treatment: When the skin is infected, antibiotic ointments such as mupirocin ointment can be used, and the short-term effect is good, but long-term use will cause local skin allergy manifestations. For mild inflammation, hormone-containing ointments such as hydrocortisone ointment can be used to reduce inflammation, but long-term use will cause the skin to atrophy, become thinner, and lose elasticity, increasing the risk of fungal infection. 3. Protecting with dressing products: Hydrocolloid dressings can be pasted on the skin of incontinence dermatitis to help keep the skin moist and promote skin healing. However, its service life is short, and the physiological curvature and wrinkles of the buttocks skin make it difficult to fix, and it is easy to loosen and be contaminated, and there is a risk of aggravating skin damage during the removal process. Summary of the Invention

[0005] The technical problem to be solved by the present invention is to provide an ointment for preventing and treating adult incontinence dermatitis and a preparation method thereof, to solve the deficiencies of existing prevention and treatment methods for incontinence dermatitis, effectively prevent the occurrence of incontinence dermatitis, promote the rapid recovery of damaged skin, and avoid the defects of traditional methods.

[0006] The technical problem to be solved by the present invention is achieved through the following technical solutions:

[0007] An adult incontinence dermatitis prevention and treatment ointment includes the following components in mass percentage: zinc oxide 15% - 25%, egg yolk oil 10% - 20%, borneol 0.8% - 2%, and petrolatum 53% - 74.2%.

[0008] Zinc oxide has the functions of astringing and protecting the skin, can reduce skin inflammation, absorb the exudate on the skin surface, helps to keep the skin dry, plays a strong protective role on the skin of incontinent patients, and also plays a certain role in promoting the recovery of incontinence dermatitis.

[0009] Egg yolk oil is a natural oil extracted from the egg yolks of fresh eggs. It is rich in nutrients such as lecithin, vitamin A, vitamin D, vitamin E, oleic acid, and linoleic acid, and plays an important role in the regeneration and metabolism of human skin. It can treat various skin and mucosal damage diseases such as eczema, mild burns, fistulas, skin cracks, and oral ulcers. For the skin of incontinent patients, egg yolk oil can form an oil film protection layer rich in nutrient elements to protect the skin and mucosa moist and intact. For patients with incontinence dermatitis, the lecithin and vitamins rich in egg yolk oil can promote the recovery of skin damage.

[0010] Borneol is a crystal extracted from the resin and volatile oil of Dryobalanops aromatica. Its chemical composition is 2-borneol. Its functions in medical treatment include resuscitating the consciousness and clearing heat and relieving pain, and it has a certain effect of improving local blood circulation. When borneol is used on the skin and mucosa, it can play the roles of clearing heat and relieving pain, and preventing infection and promoting granulation. It can relieve the pain and inflammation of the local skin and also promote wound healing. In general external preparations, the content of borneol is usually about 0.5% - 2%. The borneol content of this product is 0.8% - 2%, which is safe when used on the skin of incontinent patients.

[0011] The main component of petrolatum is petrolatum, which is a high-molecular hydrocarbon obtained from petroleum fractions. It is usually in the form of a semi-transparent ointment with a certain greasy feeling and is a common component matrix of skin care products. When petrolatum is used on the skin, it can form a protective film on the skin surface, prevent water from passing through, isolate harmful bacteria and pollutants from the outside, reduce the risk of infection, and build a good environment for the skin integrity and wound healing of incontinent patients.

[0012] Preferably, in the above technical solution, it includes the following components in mass percentage: zinc oxide 18%, egg yolk oil 10%, borneol 2%, and petrolatum 70%, or includes the following components in mass percentage: zinc oxide 20%, egg yolk oil 20%, borneol 1%, and petrolatum 59%.

[0013] Preferably, in the above technical solution, the egg yolk oil is prepared by the following method: Take fresh eggs, after cooking, peel the egg yolks, place them in a frying container, heat them over a gentle fire to remove all the moisture, and then stir-fry them over a strong fire until all the egg yolk oil is extracted. After filtering, bottle it for later use.

[0014] Preferably, in the above technical solution, the temperature of the gentle fire is 80°C to 120°C, and the temperature of the strong fire is 280°C.

[0015] Preferably, in the above technical solution, the purity requirement of the zinc oxide is higher than 99.0%.

[0016] A preparation method of an adult incontinence dermatitis prevention and treatment ointment includes the following steps:

[0017] (1) Processing egg yolk oil: Take fresh eggs, after cooking, peel the egg yolks, place them in a frying container, heat them over a gentle fire to remove all the moisture, and then stir-fry them over a strong fire until all the egg yolk oil is extracted. Filter out the egg yolk oil and bottle it for later use;

[0018] (2) Preparation of zinc oxide powder: Take zinc oxide powder with a purity higher than 99.0% that meets the pharmaceutical standard, grind it, and sieve it into a bottle for later use;

[0019] (3) Preparation of borneol powder: Take borneol and place it in a mortar, grind it into extremely fine powder, and sieve it into a bottle for later use;

[0020] (4) Melting the matrix: Weigh an appropriate amount of vaseline as the matrix raw material, put it into a heating container, heat it in a constant temperature water bath to 60°C to 75°C to melt it, and at the same time stir it with a stirrer to ensure uniform heating;

[0021] (5) Mixing and stirring: According to the formula, weigh the egg yolk oil, zinc oxide powder, and borneol powder in corresponding proportions to the mass of the vaseline matrix. First, pour the egg yolk oil into the melted matrix and continuously stir it evenly. Then add the zinc oxide powder to the matrix and continue to stir evenly. Let the solution cool to 40°C, and finally add the borneol powder to the matrix and continue to stir evenly to fully mix the egg yolk oil, zinc oxide, borneol, and the matrix.

[0022] (6) Quality inspection and storage: Take a small amount of the ointment for testing related indicators (appearance, particle size, pH value, etc.) to ensure that it meets the quality requirements. Transfer the ointment into an ointment tube or bottle, and seal it for storage. More preferably, the ointment can be transferred into an ointment tube or bottle and sealed for storage.

[0023] Preferably, in the above technical solution, the temperature of the gentle fire is 80°C to 120°C, and the temperature of the strong fire is 280°C.

[0024] A usage method of an adult incontinence dermatitis prevention and treatment ointment includes the following steps:

[0025] Take an appropriate amount of the ointment and apply it to the clean and dry skin of the parts prone to incontinence dermatitis, with a thickness of 0.5 - 1 mm, and the application range is 2 - 3 cm larger than the area for protecting or treating the skin. Use it 3 - 6 times a day.

[0026] Preferably, in the above technical solution, the parts prone to incontinence dermatitis include: perineum, buttocks, groin, inner thigh.

[0027] Application of an adult incontinence dermatitis prevention and treatment ointment in the prevention and treatment of mild to moderate incontinence dermatitis.

[0028] The above technical solution of the present invention has the following beneficial effects:

[0029] The ointment of the present invention is a product for preventing and treating incontinence dermatitis in adult incontinence patients. The components contained in this product are mild in nature, which can effectively prevent the irritation caused by pollutants such as urine and feces to the skin of incontinence patients. At the same time, it has the effects of moisturizing and protecting the skin and promoting the healing of skin wounds. Detailed implementation mode

[0030] Now, various exemplary embodiments of the present invention will be described in detail. It should be noted that: unless otherwise specifically stated, the relative arrangements, numerical expressions and numerical values of the components and steps set forth in these embodiments do not limit the scope of the present invention.

[0031] Unless otherwise specified, the experimental methods used in the following examples are all conventional methods. The materials and reagents used, unless otherwise specified, can all be obtained from commercial channels. The equipment used in the experiments, unless otherwise specified, are all well-known to those skilled in the art.

[0032] Example 1

[0033] An adult incontinence dermatitis prevention and treatment ointment, wherein there are 18 g of zinc oxide, 2 g of borneol, 10 g of egg yolk oil, and 70 g of vaseline.

[0034] The preparation method of this ointment is as follows:

[0035] 1) Prepare egg yolk oil by the frying and boiling method, filter it with gauze, take 10 g and put it in a bottle for later use;

[0036] 2) Grind zinc oxide powder through a 120 - mesh sieve, take 18 g and put it in a bottle for later use;

[0037] 3) Grind borneol into extremely fine powder, pass it through a 120 - mesh sieve, take 2 g for later use;

[0038] 4) Take 70 g of vaseline and heat it to 70 °C until it melts completely;

[0039] 5) Add egg yolk oil and zinc oxide powder to vaseline respectively and stir evenly. After placing the cooling solution to 40 °C, pour in borneol powder and continue to stir evenly until a delicate ointment is formed.

[0040] Example 2

[0041] An ointment for preventing and treating adult incontinence dermatitis, in which there are 20 g of zinc oxide, 1 g of borneol, 20 g of egg yolk oil, and 59 g of vaseline.

[0042] The preparation method of this ointment is as follows:

[0043] 1) Prepare egg yolk oil by frying method, filter with gauze and take 20 g and put it into a bottle for later use;

[0044] 2) Grind zinc oxide powder through a 120-mesh sieve, take 20 g and put it into a bottle for later use;

[0045] 3) Grind borneol into extremely fine powder, pass through a 120-mesh sieve, take 1 g for later use;

[0046] 4) Take 59 g of vaseline and heat it to 65 °C until it melts completely;

[0047] 5) Add egg yolk oil and zinc oxide powder to vaseline respectively and stir evenly. After placing the cooling solution to 40 °C, pour in borneol powder and continue to stir evenly until a delicate ointment is formed.

[0048] This product is a white or light brownish-yellow ointment with uniform texture, delicate and soft, having appropriate viscosity, and should be easily spread on the skin or mucous membrane; it does not melt, and the viscosity should change very little with seasons; it has stable properties and should have no deterioration phenomena such as rancidity, strange smell, discoloration, hardening, oil-water separation, and flatulence; the ointment formula is mild and safe, and should not easily cause skin irritation reactions, allergic reactions, and other adverse reactions; substances such as zinc oxide, borneol, and egg yolk oil should be evenly dispersed in vaseline to form a delicate ointment.

[0049] The quality inspection of this invention should comply with the relevant regulations under General Rules 0109 Ointments in Part IV of Chinese Pharmacopoeia 2020 Edition:

[0050] Particle size: Take an appropriate amount of the test sample, apply it on a glass slide to form a thin layer, the area of the thin layer is equivalent to the area of the cover glass, apply 3 slides in total, and determine according to the method for the determination of particle size and particle size distribution (General Rule 0982, Method 1), and no particles larger than 180 μm shall be detected.

[0051] Filling quantity: Check according to the method for the inspection of minimum filling quantity (General Rule 0942), and it should comply with the regulations.

[0052] Microbial limit: Check according to the method for microbial counting (General Rule 1105), the method for the inspection of controlled bacteria (General Rule 1106), and the microbial limit standards for non-sterile drugs (General Rule 1107), and it should comply with the regulations.

[0053] Usage method of this product: Take an appropriate amount of the ointment and apply it on the skin of the perineum, buttocks, groin, inner thigh and other parts where incontinence dermatitis is likely to occur, usually a thin layer with a thickness of 0.5 - 1 mm to cover the skin surface. The application range should be 2 - 3 cm larger than the skin to be protected or treated. It can be used 3 - 6 times a day. Due to individual physical constitution, it is recommended to conduct a small-area trial on the inner side of the forearm skin of the user before using this drug, and observe whether there are adverse reactions such as allergies 20 minutes later. If there is an allergic reaction, it is not recommended to use.

[0054] Effect: This drug has good preventive and therapeutic effects, has a protective effect on the skin and mucosa of incontinent patients, can play a certain preventive role in the occurrence of incontinence dermatitis, and has a good effect on the treatment of mild to moderate incontinence dermatitis.

[0055] This drug has significant effects of skin protection, bacteriostasis and pain relief, and promoting skin healing. The treatment time is short and the cure rate is high. The usage is to apply it on the skin areas where incontinence dermatitis is prone to occur, or on the skin surface where mild to moderate incontinence dermatitis has already occurred. The application range should be 2 - 3 cm larger than the skin to be protected or treated, with a thickness of 0.5 - 1 mm, and it can be used 3 - 6 times a day.

[0056] Typical cases:

[0057] Case 1: Chen, female, 68 years old, has been bedridden due to spinal stenosis and limited mobility for many years, with partial self-care ability defects. This time, she was hospitalized for the treatment of colon cancer and had urinary and fecal incontinence. A urinary catheter was retained after admission. There was obvious skin redness from Chen's perianal area to the buttocks, the perianal skin was eroded and flushing, with an ulcer surface and a small amount of bleeding, and the pain was obvious, which was severe incontinence dermatitis. After thoroughly cleaning the perianal and buttock skin with clear water and wiping dry the moisture, the ointment prepared by the method of Example 1 was applied. The application area of the ointment was 2 cm larger than the edge of the skin redness area. The skin was cleaned with clear water and the drug was applied 3 - 6 times a day. After 3 days of medication, Chen reported that the perianal pain was relieved. The perianal ulcer surface was dry without obvious exudate and had a shrinking trend, and the skin redness area of the buttocks shrank. After 7 days of medication, the perianal pain was significantly relieved, the ulcer surface was partially healed, and the buttock skin returned to normal. After 14 days of medication, the perianal skin returned to normal and the rash healed.

[0058] Case 2, Zhang, female, 89 years old, had weak limbs and was bedridden for a long time after cerebral infarction. She had defects in self-care ability and incontinence. Zhang's perianal, bilateral groin and inner thigh skin showed obvious skin redness, and some perianal skin was red, swollen and moist, with scattered superficial ulcers, and was diagnosed as incontinence dermatitis. After thoroughly cleaning the perianal, bilateral groin and inner thigh skin with clean water, wipe the water and evenly apply the ointment prepared in Example 1. The ointment application area was 2 cm larger than the edge of the skin redness area. Zhang cleaned the skin with clean water after two bowel movements and applied the ointment at any time. Apply at least 4 times a day. After 3 days of medication, the perianal skin redness and swelling were reduced, the superficial ulcers were significantly improved, and the redness area of ​​the bilateral groin and inner thigh skin was reduced; after 7 days of medication, the skin color of the bilateral groin and inner thigh returned to normal, and the superficial ulcers of the perianal skin disappeared; after 10 days of medication, Zhang's perianal skin returned to normal, and incontinence dermatitis was cured. Continue to use the same method to preventively apply the ointment to the anus, buttocks, groin and inner thighs. After 14 days of medication, the above skin is intact, and no abnormal phenomena such as rash and color change occur.

[0059] Case 3, Wu, male, 40 years old, was treated in the hospital for high fever for several days. The patient was bedridden and had some self-care abilities. During the treatment, he had antibiotic-related diarrhea and had watery diarrhea several times a day. On the third day, Wu's perianal skin was flaky pink, the skin was still intact, with increased skin temperature and obvious pain. Diagnosed as mild incontinence dermatitis. After thoroughly cleaning the perianal skin with clean water and wiping dry the water, the ointment configured by the method of Example 1 was used. The ointment application area was larger than the reddened skin area. After each diarrhea, the skin was cleaned with clean water and the ointment was applied again. After taking the medicine for 1 day, Wu complained that the perianal pain disappeared and the perianal skin redness area was smaller than before; after taking the medicine for 2 days, Wu's perianal skin redness subsided and the dermatitis was basically cured. Combined with antidiarrheal treatment, Wu's antibiotic-related diarrhea improved after 7 days. During this period, the ointment was used to protect the perianal skin with good effect, and no dermatitis symptoms recurred.

[0060] Although the present invention has been disclosed as above by the embodiments, it is not intended to limit the present invention. Any person skilled in the art may make various choices and modifications without departing from the spirit and scope of the present invention. Therefore, the protection scope of the present invention is limited by the claims and their equivalents.

Claims

1. An ointment for preventing and treating incontinence dermatitis in adults, characterized in that: The invention comprises the following components in percentage by mass: 15% to 25% zinc oxide, 10% to 20% egg yolk oil, 0.8% to 2% borneol and 53% to 74.2% vaseline.

2. The ointment for preventing and treating incontinence dermatitis in adults according to claim 1, characterized in that The invention comprises the following components in mass percentage: 18% zinc oxide, 10% egg yolk oil, 2% borneol, and 70% vaseline; or the following components in mass percentage: 20% zinc oxide, 20% egg yolk oil, 1% borneol, and 59% vaseline.

3. The ointment for preventing and treating incontinence dermatitis in adults according to claim 2, characterized in that: The egg yolk oil is prepared by the following method: fresh eggs are taken, the yolks are peeled off after being cooked, and the eggs are placed in a frying container, heated with a slow fire to remove all moisture, and then fried with a high fire until all the egg yolk oil comes out, and then filtered and bottled for later use.

4. The ointment for preventing and treating incontinence dermatitis in adults according to claim 3, characterized in that: The temperature of the slow fire is 80°C to 120°C, and the temperature of the high fire is 280°C.

5. The ointment for preventing and treating incontinence dermatitis in adults according to claim 3, characterized in that: The purity of the zinc oxide is required to be higher than 99.0%.

6. The method for preparing the ointment for preventing and treating incontinence dermatitis in adults according to any one of claims 1 to 5, characterized in that: The following steps are involved: (1) Preparation of egg yolk oil: Take fresh eggs, boil them, peel off the egg yolks, put them in a frying container, heat them over a low heat, remove all the water, and then fry them over a high heat until all the egg yolk oil comes out, filter out the egg yolk oil and bottle it for later use; (2) Preparation of zinc oxide powder: Grind zinc oxide powder with a purity higher than 99.0% and meeting pharmaceutical standards, sieve and bottle for later use; (3) Preparation of borneol powder: Place borneol in a mortar and grind into very fine powder, sieve and bottle for later use; (4) Melting of matrix: Weigh an appropriate amount of vaseline as the matrix raw material, put it into a heating container, heat it to 60°C to 75°C in a constant temperature water bath to melt it, and stir it with a stirrer to ensure uniform heating; (5) Mixing and stirring: According to the formula, weigh egg yolk oil, zinc oxide powder, and borneol powder in a corresponding proportion to the mass of the vaseline matrix. First, pour the egg yolk oil into the molten matrix and continue to stir evenly. Then add the zinc oxide powder into the matrix and continue to stir evenly. Let the solution cool to 40°C. Finally, add the borneol powder into the matrix and continue to stir evenly to fully mix the egg yolk oil, zinc oxide, borneol and the matrix. (6) Quality inspection and storage: Take a small amount of ointment to test relevant indicators to ensure that it meets the quality requirements and store it in a sealed container for future use.

7. The method for preparing the ointment for preventing and treating incontinence dermatitis in adults according to claim 6, characterized in that: The temperature of the slow fire is 80°C to 120°C, and the temperature of the high fire is 280°C.

8. A method for using the ointment for preventing and treating incontinence dermatitis in adults prepared according to any one of the preparation methods of claims 6-7, characterized in that: The following steps are involved: Apply an appropriate amount of ointment to clean, dry skin in areas prone to incontinence dermatitis, with a thickness of 0.5-1mm. The application area should be 2-3cm larger than the protected or treated skin. Use 3-6 times a day.

9. The method of use according to claim 8, characterized in that: The areas prone to incontinence dermatitis include: perineum, buttocks, groin, and inner thighs.

10. Use of the adult incontinence dermatitis prevention and treatment ointment prepared according to any one of claims 6-7 in preventing and treating mild to moderate incontinence dermatitis.