Supramolecular hydrogel composition as well as preparation method and application thereof

Abstract

The invention discloses a supramolecular hydrogel composition as well as a preparation method and application thereof, and belongs to the technical field of beauty treatment. The supramolecular hydrogel composition provided by the invention is prepared from the following raw materials in percentage by mass: the balance of water; 2 to 30 percent of poloxamer; 1-35% of an active substance; 0.5%-20% of a cross-linking agent; and 1-20% of polyol. The supramolecular hydrogel composition provided by the invention can significantly reduce the irritation to the skin on the basis of effectively improving the content of active substances and the bioavailability of the active substances in the supramolecular hydrogel composition. The invention also provides a preparation method and application of the supramolecular hydrogel composition.

Description

Technical Field

[0001] The present invention relates to the field of cosmetic technology, and in particular to a supramolecular hydrogel composition, a preparation method and an application thereof. Background Art

[0002] As we all know, in the fields of beauty care, chemical peels, and treatment of stubborn skin diseases, many ingredients that are effective and can address consumers' needs for beauty care, chemical peels, and treatment of stubborn skin diseases generally have two problems: one is that they are insoluble or slightly soluble in water; the other is that they are easily soluble in water but can cause severe irritation to the skin or even damage the skin when added in high concentrations.

[0003] Supramolecular hydrogels can form aggregates with ordered structures through weak intermolecular interactions (non-covalent bonds). Under the synergistic effect of non-covalent bonds, multiple molecules can self-assemble into new long-chain polymers (ABC). However, under external stimuli (such as temperature), the stable non-covalent synergistic effects are disrupted, forming new structures (CBA) and generating new functions.

[0004] However, the supramolecular hydrogels prepared using traditional technologies either have low solubility of active ingredients therein or cannot effectively alleviate the irritation of active ingredients to the skin. Summary of the Invention

[0005] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a supramolecular hydrogel composition that can significantly reduce its irritation to the skin while effectively increasing the content and bioavailability of active substances therein.

[0006] The present invention also provides a method for preparing the supramolecular hydrogel composition.

[0007] The present invention also provides the application of the supramolecular hydrogel composition in the field of preparing skin care products.

[0008] According to an embodiment of the first aspect of the present invention, a supramolecular hydrogel composition is provided. The raw materials for preparing the supramolecular hydrogel composition include, by mass percentage:

[0009]

[0010] The supramolecular hydrogel composition according to the embodiment of the present invention has at least the following beneficial effects:

[0011] (1) The supramolecular hydrogel composition provided by the present invention can significantly increase the solubility of the active substance (maximum concentration of uniform dispersion) through the synergistic effect between the preparation raw materials, thereby improving the bioavailability of the active substance and fundamentally solving the solubility problem of insoluble or slightly water-soluble active substances.

[0012] (2) For active substances that are easily water-soluble but cause severe skin irritation or even damage when added in high concentrations, the encapsulation of the active substances is improved (equivalent to a certain degree of controlled release), which not only reduces the irritation to human skin, but also continuously delivers the active substances to the skin, and is safer and more tolerable at high concentrations; it solves the technical problem of consumers' intolerance to such high-concentration active substances; and thus meets the needs of consumers for beauty care and chemical peel products.

[0013] (3) The supramolecular hydrogel composition provided by the present invention abandons the traditional alcohol dissolution method, which not only avoids the irritation of alcohol, but also does not reduce the effect of the active substance due to recrystallization of the active substance caused by alcohol volatilization.

[0014] (4) The unique hydrogel system provided by the present invention can improve skin hydration, which is more conducive to the absorption and penetration of active substances, retaining the original efficacy of the active substances and having a more obvious effect.

[0015] Therefore, the present invention aims to invent a supramolecular hydrogel composition that can effectively solve the problem of active substances being difficult to dissolve and the problem of active substances being highly irritating at high concentrations.

[0016] According to some embodiments of the present invention, the poloxamer is a polyoxyethylene-polyoxypropylene ether nonionic triblock copolymer composed of polyoxyethylene (PEO) and polyoxypropylene (PPO).

[0017] According to some embodiments of the present invention, the poloxamer includes at least one of poloxamer 101, poloxamer 124, poloxamer 182, poloxamer 184, poloxamer 185, poloxamer 188, poloxamer 215, poloxamer 234, poloxamer 235, poloxamer 238, poloxamer 331, poloxamer 338 and poloxamer 407 (CAS No.: 9003-11-6).

[0018] According to some embodiments of the present invention, the mass percentage of the poloxamer in the raw materials for preparing the supramolecular hydrogel composition is 5-20%, for example, about 8%, 10%, 12%, 14%, 15%, 16% or about 18%.

[0019] According to some embodiments of the present invention, the active substance is a skin care active substance.

[0020] According to some embodiments of the present invention, the active substance is at least one of a water-insoluble substance, a slightly water-soluble substance, or a water-soluble and skin-irritating substance.

[0021] According to some embodiments of the present invention, the active substance includes at least one of phenylethylresorcinol, vitamin C and its derivatives, 4-butylresorcinol, potassium 4-methoxysalicylate, azelaic acid, arbutin, glabridin, ferulic acid, kojic acid, ellagic acid, tranexamic acid, retinol and its derivatives, salicylic acid (CAS No.: 69-72-7) and its derivatives, and α-hydroxy acid, wherein the α-hydroxy acid includes glycolic acid (CAS: 79-14-1).

[0022] According to some embodiments of the present invention, the mass percentage of the active substance in the raw materials for preparing the supramolecular hydrogel composition is 2-30%, for example, about 5%, 10%, 12%, 15%, 18%, 20% or about 25%.

[0023] According to some embodiments of the present invention, the crosslinking agent includes at least one of polyethylene glycol nonionic emulsifiers, fatty alcohol polyether emulsifiers, carbon alkyl glucoside, lauryl alcohol polyether surfactants, glyceryl stearate, carbon alkyl alcohol, and derivatives of the above substances.

[0024] According to some embodiments of the present invention, the mass percentage of the cross-linking agent in the raw materials for preparing the supramolecular hydrogel composition is 1-5%, for example, about 2%, 3% or about 4%.

[0025] According to some embodiments of the present invention, the polyol includes at least one of glycerol, propylene glycol (CAS: 57-55-6), 1,3-propanediol, butylene glycol, dipropylene glycol, ethoxydiglycol, hexylene glycol, pentylene glycol, polyethylene glycol, and derivatives thereof.

[0026] According to some embodiments of the present invention, the mass percentage of the polyol in the raw materials for preparing the supramolecular hydrogel composition is 10-20%, for example, about 12%, 14%, 15%, 16% or about 18%.

[0027] According to some embodiments of the present invention, the raw materials for preparing the supramolecular hydrogel composition further include at least one of an emollient and a preservative.

[0028] According to some embodiments of the present invention, in the supramolecular hydrogel composition, the mass percentage of the emollient is 1 to 20%.

[0029] According to some embodiments of the present invention, the emollient includes at least one of silicone oil, petrolatum, fatty alcohols, hydrogenated polyisobutene, squalane, hydrogenated polydecene, tridecyl trimellitate, isononyl isononanoate, caprylic triglyceride, capric triglyceride, triethylhexanoin, isopropyl myristate, ethylhexyl palmitate and vegetable oil.

[0030] According to some embodiments of the present invention, the fatty alcohol includes octyl dodecanol.

[0031] According to some embodiments of the invention, the vegetable oil comprises jojoba seed oil.

[0032] According to some embodiments of the present invention, the amount of the preservative added meets the requirements of the "Technical Specifications for Safety of Cosmetics".

[0033] According to an embodiment of the second aspect of the present invention, a first preparation method of the supramolecular hydrogel composition is provided, the first preparation method comprising the following steps:

[0034] S1. Mixing part of the poloxamer and water to obtain component A;

[0035] After mixing the active substance and the polyol, the active substance and the remaining poloxamer and the cross-linking agent are sequentially mixed, and ultrasonic mixing is continued to obtain component B;

[0036] S2. Mix the A component and the B component.

[0037] During the preparation of component B, the polyol can increase the solubility of the active substance, especially those with low solubility in water. The active substance is then dispersed in the poloxamer. Furthermore, the poloxamer undergoes crosslinking under the action of the crosslinker, immobilizing the active substance and preventing its recrystallization. The crosslinked product can serve as a sustained-release matrix for the active substance, preventing large amounts of the active substance from coming into direct contact with the skin and reducing skin irritation. The immobilization of the crosslinked product also prevents the active substance from re-precipitating during subsequent mixing with component A. Furthermore, during the mixing process, the crosslinker also acts as a surfactant, significantly improving the uniformity of the active substance's dispersion.

[0038] Since the first preparation method adopts all the technical solutions of the supramolecular hydrogel composition of the above embodiment, it has at least all the beneficial effects brought by the technical solutions of the above embodiment.

[0039] The first preparation method provided by the present invention significantly improves the encapsulation of the gel matrix for the active substance, increases the solubility of the insoluble active substance, and reduces the irritation of the active substance to the skin by limiting the reasonable addition order.

[0040] In addition, during the preparation of the B component, ultrasound is selected as the method for improving mass transfer. Compared with stirring, it is more conducive to improving the uniformity of the B component. Compared with methods such as wall breaking, it is more conducive to large-scale production and avoids irreversible damage to the components during the wall breaking process.

[0041] In general, the first preparation method is applicable to all kinds of active substances, regardless of whether the active substances need to be water-soluble or not, and what their solubility in the matrix is.

[0042] According to some embodiments of the present invention, in step S1, the mass percentage of the portion of the poloxamer to the total mass of the poloxamer is 45-55%.

[0043] According to some embodiments of the present invention, in step S1, during the mixing process of component A, the temperature is 0-8° C., for example, about 2° C., 4° C., or about 6° C. After the mixing is completed, the temperature is returned to room temperature.

[0044] According to some embodiments of the present invention, in step S1, the mixing of component A is performed under stirring. The present invention does not impose strict restrictions on the duration and speed of stirring, as long as mass transfer is improved and mixing is uniform.

[0045] According to some embodiments of the present invention, in step S1, during the preparation of component B, the temperature is 90-95°C, for example, about 92°C or about 94°C.

[0046] According to some embodiments of the present invention, in step S1, the polyol and the active substance are mixed by stirring for 80 to 100 minutes; for example, the stirring time may be about 85 minutes, 90 minutes, or about 95 minutes.

[0047] According to some embodiments of the present invention, in step S1, after the remaining poloxamer is added, stirring and mixing is continued for 80 to 100 minutes; for example, the stirring and mixing may be about 85 minutes, 90 minutes, or about 95 minutes.

[0048] According to some embodiments of the present invention, in step S1, after adding the cross-linking agent, stirring and mixing need to be continued for 100 to 150 minutes, for example, about 110 minutes, 120 minutes, 130 minutes, or about 140 minutes.

[0049] By utilizing the above-mentioned adding and mixing methods, the dispersion degree of the active substance in the supramolecular hydrogel composition can be further improved, thereby reducing irritation to the skin.

[0050] According to some embodiments of the present invention, step S1 further includes adding an emollient to the system of component B after adding the crosslinking agent and before ultrasonic mixing, and stirring the mixture at room temperature for 20 to 40 minutes, for example, about 30 minutes.

[0051] According to some embodiments of the present invention, in step S1, the ultrasonic mixing frequency is 35-45 kHz; for example, it may be about 40 kHz.

[0052] According to some embodiments of the present invention, in step S1, the duration of the ultrasonic mixing is 20 to 40 minutes, for example, about 25 minutes, 30 minutes, or about 35 minutes.

[0053] According to some embodiments of the present invention, in step S1, the ultrasonic mixing is performed while continuously stirring, thereby the two methods of improving mass transfer work together to further improve the mass transfer effect.

[0054] According to some embodiments of the present invention, step S2 further includes adding a preservative during the mixing process.

[0055] According to some embodiments of the present invention, in step S2, the end point of the mixing is until a gel is formed. The specific mixing method can be stirring, but the specific method and duration are not strictly limited by the present invention.

[0056] According to an embodiment of the third aspect of the present invention, a second preparation method of the supramolecular hydrogel composition is provided, the second preparation method comprising the following steps:

[0057] D1. mixing the poloxamer and water;

[0058] D2. The mixture of the active substance and the polyol is mixed with the mixture obtained in step D1;

[0059] D3. Mix the cross-linking agent with the mixture obtained in step D2.

[0060] Since the second preparation method adopts all the technical solutions of the supramolecular hydrogel composition of the above embodiment, it has at least all the beneficial effects brought by the technical solutions of the above embodiment.

[0061] The second preparation method is simpler than the first and is suitable for substances that are less irritating to the skin and are water-soluble. If the active substance meets the above requirements, the second preparation method can be used in industry to increase production capacity.

[0062] According to some embodiments of the present invention, in step D1, the mixing method includes stirring.

[0063] According to some embodiments of the present invention, in step D1, the mixing temperature is 0-8°C.

[0064] According to some embodiments of the present invention, step D1 further includes restoring the obtained mixture to room temperature during the mixing.

[0065] According to some embodiments of the present invention, in step D2, the mixing further comprises adding the emollient.

[0066] According to some embodiments of the present invention, in step D3, the mixing further comprises adding the preservative.

[0067] The mixing method of step D2 and step D3 includes stirring. As for the stirring time and speed, the present invention does not impose strict restrictions, and it only needs to meet the requirements of uniform mixing in step D2 and gel formation in step D3.

[0068] According to an embodiment of the third aspect of the present invention, there is provided an application of the supramolecular hydrogel composition in the preparation of skin care products.

[0069] Since the application adopts all the technical solutions of the supramolecular hydrogel composition of the above embodiment, it at least has all the beneficial effects brought by the technical solutions of the above embodiment.

[0070] Unless otherwise specified, the term “about” in the present invention actually means that the error is allowed to be within the range of ±2%, for example, about 100 actually means 100±2%×100.

[0071] Other features and advantages of the present invention will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0072] The above and / or additional aspects and advantages of the present invention will become apparent and readily understood from the following description of the embodiments with reference to the accompanying drawings, in which:

[0073] Figure 1 This is the microscopic morphology of the supramolecular hydrogel composition obtained in Example 2 of the present invention;

[0074] Figure 2 This is the microscopic morphology of the supramolecular hydrogel composition obtained in Comparative Example 1 of the present invention;

[0075] Figure 3 This is the microscopic morphology of the supramolecular hydrogel composition obtained in Comparative Example 2 of the present invention;

[0076] Figure 4 This is the microscopic morphology of the supramolecular hydrogel composition obtained in Comparative Example 3 of the present invention;

[0077] Figure 5 This is the microscopic morphology of the supramolecular hydrogel composition obtained in Comparative Example 4 of the present invention;

[0078] Figure 6 This is the microscopic morphology of the supramolecular hydrogel composition obtained in Comparative Example 5 of the present invention. DETAILED DESCRIPTION

[0079] The following will clearly and completely describe the concept and technical effects of the present invention in conjunction with the embodiments to fully understand the purpose, features and effects of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, other embodiments obtained by those skilled in the art without creative work are all within the scope of protection of the present invention.

[0080] In the description of the present invention, reference to terms such as "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the exemplary expressions of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0081] Unless otherwise specified, the room temperature in the specific embodiment is 22-28° C.; and temperature changes within this range will not affect the specific properties of the obtained supramolecular hydrogel composition.

[0082] Example 1

[0083] In this example, a supramolecular hydrogel composition was prepared. The composition of the raw materials used for the preparation is shown in Table 1. The specific process is as follows:

[0084] S1. 50 wt% of poloxamer and water were stirred and mixed at about 5 ° C, and then returned to room temperature to obtain component A;

[0085] The active substance and polyol were stirred at about 92°C for 90 minutes, and then the remaining poloxamer was added and stirred at about 92°C for 90 minutes. The cross-linking agent was then added and stirred at about 92°C for 120 minutes. Finally, the mixture was ultrasonically treated at a frequency of 40 kHz for 30 minutes while still stirring to obtain component B.

[0086] S2. Mix components A and B.

[0087] Table 1 Raw materials for preparing the supramolecular hydrogel composition of the embodiment

[0088]

[0089]

[0090] Example 2

[0091] This example prepares a supramolecular hydrogel composition, which differs from Example 1 in that:

[0092] The raw materials for preparation are slightly different, and the specific differences are shown in Table 1.

[0093] Example 3

[0094] This example prepares a supramolecular hydrogel composition, which differs from Example 1 in that:

[0095] The raw materials for preparation are slightly different, and the specific differences are shown in Table 1.

[0096] Example 4

[0097] This example prepares a supramolecular hydrogel composition, which differs from Example 1 in that:

[0098] The raw materials for preparation are slightly different, and the specific differences are shown in Table 1.

[0099] The preparation methods are different, and the specific steps are as follows:

[0100] D1. Mix poloxamer with water and stir at approximately 4°C to fully dissolve the mixture. Then, allow the mixture to return to room temperature to obtain a poloxamer hydrogel.

[0101] D2. The active substance and polyol are added to the mixture obtained in step D1 and stirred to dissolve evenly;

[0102] D3. Add the crosslinking agent to the mixture obtained in step D2 and stir to disperse evenly until it becomes a gel.

[0103] Example 5

[0104] This example prepares a supramolecular hydrogel composition, which differs from Example 1 in that:

[0105] The raw materials for preparation are slightly different, and the specific differences are shown in Table 1.

[0106] In the preparation method, in step S1, the following step is further added before the ultrasonic treatment: adding an emollient and stirring and mixing for 30 minutes.

[0107] Comparative Example 1

[0108] This example prepares a supramolecular hydrogel composition, which differs from Example 2 in that:

[0109] During the preparation of the raw materials and component B, no laureth-4 (crosslinking agent) was added.

[0110] Comparative Example 2

[0111] This example prepares a supramolecular hydrogel composition, which differs from Example 2 in that:

[0112] During the preparation of the raw materials and component B, no polyol is added.

[0113] Comparative Example 3

[0114] This example prepares a supramolecular hydrogel composition, which differs from Example 2 in that:

[0115] All the poloxamer was added to component A. During the preparation of component B, no poloxamer was added.

[0116] Comparative Example 4

[0117] This example prepares a supramolecular hydrogel composition, which differs from Example 2 in that:

[0118] The preparation process of component B is adjusted as follows:

[0119] The active substance and the cross-linking agent were stirred and mixed at about 92° C. for 120 minutes, and then the polyol was added and stirred and mixed at about 92° C. for 90 minutes. The remaining poloxamer was then added and stirred and mixed at about 92° C. for 90 minutes. Finally, ultrasonic treatment was performed at a frequency of 40 kHz for 30 minutes.

[0120] Comparative Example 5

[0121] This example prepares a supramolecular hydrogel composition, which differs from Example 2 in that:

[0122] The preparation process of component B is adjusted as follows:

[0123] The active substance and the remaining poloxamer were stirred and mixed at about 92° C. for 90 minutes, and then the cross-linking agent was added and stirred and mixed at about 92° C. for 120 minutes. Then, the polyol was added and stirred and mixed at about 92° C. for 90 minutes. Finally, ultrasonic treatment was performed at a frequency of 40 kHz for 30 minutes.

[0124] Comparative Example 6

[0125] This example prepares a supramolecular hydrogel composition, which differs from Example 4 in that:

[0126] No poloxamer and laureth-4 are added to the preparation raw materials.

[0127] Test Example 1

[0128] This example tests the microscopic morphology of the supramolecular hydrogel compositions obtained in the examples and comparative examples, and the test method is observation under a 40x magnifying glass. The results show that in the supramolecular hydrogel compositions obtained in the examples, the active substances are crystallized, the particle size is uniform, and the distribution is orderly and hierarchical. In comparative example 1, due to the inability to form a gel, the microscopic imaging shows that the active substance salicylic acid is distributed in a disorderly manner. In comparative examples 2-3, the particle size of salicylic acid is large and uneven, which shows that in the supramolecular hydrogel compositions provided by the present invention, the polyol can assist the redissolution of the active substance, and the poloxamer added during the preparation of component B, combined with the cross-linking agent, can form a matrix that fixes and encapsulates the active substance, preventing the active substance from increasing in particle size and irritating the skin during storage and use. Comparative examples 4-5 show that the particle size of the active substances varies greatly. It can be expected that active substances with large particle sizes will cause skin irritation during use; thus, it can be seen that the order of adding the raw materials in the preparation can also significantly affect the performance of the product. The results of Comparative Example 6 show that it is a uniform and transparent liquid, which shows that for active substances that are easily water-soluble, poloxamer and laureth-4 are required to fix them during the preparation process of the supramolecular hydrogel composition in order to obtain a low-irritation supramolecular hydrogel composition. Furthermore, the present invention also verifies that if all the poloxamer is added to component B and then component B is mixed with water (the preparation process in the traditional process), the active substance in the resulting supramolecular hydrogel composition is easily crystallized and precipitated, making it difficult to use in actual production, and the state under the microscope is even worse than that of Comparative Examples 2 to 3. The specific results are as follows Figures 1 to 6 shown.

[0129] Test Example 2

[0130] This example tested the skin feel of the supramolecular hydrogel compositions obtained in the Examples and Comparative Examples. The testing method was as follows: the corresponding supramolecular hydrogel composition was applied to the skin and the skin was tested for a granular or sandy feel (similar to the feeling of fine sand applied to the skin surface). The test results showed a trend consistent with the state observed under the microscope in Test Example 1, that is, the skin feel of the product obtained in the Examples was delicate, while the Comparative Examples had a sandy or granular feel. This shows to some extent that the supramolecular hydrogel composition provided by the present invention has improved consumers' skin acceptance of specific active substances. The specific test results are shown in Table 2.

[0131] Table 2 Skin feel test results of the supramolecular hydrogel compositions obtained in Examples and Comparative Examples

[0132] Group Skin feel Example 2 Gel-like, delicate skin feel, no slight sandy feeling, no granular feeling Comparative Example 1 Emulsion-like, cannot form a gel Comparative Example 2 Obvious graininess Comparative Example 3 Obvious graininess Comparative Example 4 Slightly sandy feeling Comparative Example 5 Slightly sandy feeling Comparative Example 6 Uniform transparent liquid, water-like touch

[0133] Test Example 3

[0134] This example also tested the skin irritation test of the supramolecular hydrogel compositions obtained in the examples and comparative examples. The test method was as follows: 5 volunteers were selected as test subjects, and a total of 11 test areas of 3 cm × 3 cm were selected on both sides of the spine on the back. The test areas on the left side of the spine from top to bottom were test area 1, test area 2, test area 3, test area 4, test area 8, and test area 9, and about 0.5 g of Example 2, Comparative Example 1, Comparative Example 2, Comparative Example 3, Example 3, and Example 4 were applied respectively; the test areas on the right side of the spine from top to bottom were test area 5, test area 6, test area 7, test area 10, and test area 11, and about 0.5 g of Comparative Example 4, Comparative Example 5, Comparative Example 6, Example 1, and Example 5 were applied respectively; 4 hours after application, the skin was washed with water to remove the residue, and the skin was applied once a day for 14 consecutive days. Then, observe the results 24 hours after each application and score the irritation reaction according to the scoring criteria of Table 3. Then, use the average score per person per day (irritation index) to evaluate the level of irritation intensity of the test substance on human skin according to Table 4. The calculation method of the average score per person per day (irritation index) is:

[0135]

[0136] The test results show that the supramolecular hydrogel compositions obtained in the examples have almost no irritation to the skin, but the supramolecular hydrogel compositions obtained in the comparative examples have some irritation to the skin. The specific results are shown in Tables 5 to 7.

[0137] Table 3 Scoring criteria for skin irritation reactions

[0138]

[0139] Table 4 Skin irritation intensity classification

[0140] Average points per person per day (stimulation index) Stimulation intensity level 0～＜0.5 Non-irritating 0.5～＜2.0 Mild irritation 2.0～＜6.0 Moderate irritation 6.0～8.0 Strong irritation

[0141] Table 5 Scoring results of multiple intact skin irritation tests

[0142]

[0143]

[0144] Table 6 Scoring results of multiple intact skin irritation tests

[0145]

[0146] Table 7 Skin irritation intensity levels of Example 2 and Comparative Examples 1 to 6

[0147] Group Stimulation intensity level Example 2 Non-irritating Comparative Example 1 Mild irritation Comparative Example 2 Moderate irritation Comparative Example 3 Moderate irritation Comparative Example 4 Mild irritation Comparative Example 5 Mild irritation Example 1 Non-irritating Example 3 Mild irritation Example 4 Non-irritating Example 5 Non-irritating Comparative Example 6 Mild irritation

[0148] In summary, the supramolecular hydrogel composition prepared by the formulation system and preparation method of the present invention can greatly improve the solubility of insoluble or slightly water-soluble active substances, and reduce the irritation of ingredients that are readily water-soluble but can cause severe skin irritation or even damage the skin when added in high concentrations.

[0149] Furthermore, stability tests were conducted between -18°C and 40°C. The results showed that the resulting supramolecular hydrogel composition remained unchanged within this temperature range, including after returning to room temperature following the stability test. No crystals were precipitated, and the microscopic morphology remained unchanged. This demonstrates that the supramolecular hydrogel composition produced by the present invention has excellent temperature stability.

[0150] Due to the above-mentioned excellent properties, the supramolecular hydrogel composition provided by the present invention is expected to be widely used in the field of preparing skin care products.

[0151] While the embodiments of the present invention have been described in detail above with reference to the accompanying drawings, the present invention is not limited to the embodiments described above. Various modifications may be made within the scope of knowledge possessed by a person skilled in the art without departing from the spirit of the present invention. Furthermore, the embodiments of the present invention and the features thereof may be combined with one another unless there is a conflict.

Claims

1. A supramolecular hydrogel composition, characterized in that: Calculated by mass percentage, the raw materials for preparing the supramolecular hydrogel composition include:

2. The supramolecular hydrogel composition according to claim 1, characterized in that The active substance includes at least one of phenylethylresorcinol, vitamin C and its derivatives, 4-butylresorcinol, potassium 4-methoxysalicylate, azelaic acid, arbutin, glabridin, ferulic acid, kojic acid, ellagic acid, tranexamic acid, retinol and its derivatives, salicylic acid and its derivatives, and α-hydroxy acid.

3. The supramolecular hydrogel composition according to claim 1, characterized in that The crosslinking agent includes at least one of polyethylene glycol nonionic emulsifiers, fatty alcohol polyether emulsifiers, carbonyl glucoside, lauryl alcohol polyether surfactants, glyceryl stearate, carbonyl alcohol, and derivatives of the above substances.

4. The supramolecular hydrogel composition according to claim 1, characterized in that The polyol includes at least one of glycerol, propylene glycol, 1,3-propanediol, butylene glycol, dipropylene glycol, ethoxydiglycol, hexylene glycol, pentylene glycol, polyethylene glycol, and derivatives thereof.

5. The supramolecular hydrogel composition according to any one of claims 1 to 4, characterized in that The raw materials for preparing the supramolecular hydrogel composition further include at least one of an emollient and a preservative.

6. A first method for preparing the supramolecular hydrogel composition according to any one of claims 1 to 5, characterized in that: The first preparation method comprises the following steps: S1. Mixing part of the poloxamer and water to obtain component A; After mixing the active substance and the polyol, the active substance and the remaining poloxamer and the cross-linking agent are sequentially mixed, and ultrasonic mixing is continued to obtain component B; S2. Mix the A component and the B component.

7. The first preparation method according to claim 6, characterized in that: In step S1, the mass percentage of the part of the poloxamer to the total amount of the poloxamer is 45-55%; and / or, in step S1, the temperature during the preparation of the component B is 90-95°C.

8. The first preparation method according to claim 6, characterized in that: In step S1, the ultrasonic mixing frequency is 35 to 45 kHz.

9. A second method for preparing the supramolecular hydrogel composition according to any one of claims 1 to 5, characterized in that: The second preparation method comprises the following steps: D1. mixing the poloxamer and water; D2. The mixture of the active substance and the polyol is mixed with the mixture obtained in step D1; D3. Mix the cross-linking agent with the mixture obtained in step D2.

10. Use of the supramolecular hydrogel composition according to any one of claims 1 to 5 in the preparation of skin care products.

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