Traditional Chinese medicine dripping pill for treating pharyngitis and preparation method thereof

Abstract

The invention discloses a Chinese medicine pill for treating pharyngitis and a preparation method thereof, relating to the technical field of Chinese medicine preparations. The Chinese medicine pill is prepared from the following raw materials in parts by weight: 13-18 parts of Sarcandra scabra, 10-20 parts of Ophiopogon japonicus, 2-4 parts of Sterculia lycopersicum, 3-5 parts of Arctium lappa, 3-5 parts of Scutellaria baicalensis, 5-7 parts of Licorice root, 4-6 parts of Puffball, 4-6 parts of Viola yedoensis, 2-4 parts of Hedyotis diffusa, 3-5 parts of Taraxacum mongolicum, 2-4 parts of Houttuynia cordata, 1-3 parts of Scutellaria barbata, 2-4 parts of Crocus sativus, 1-3 parts of Water celery, 0.3-0.5 parts of Artemisia annua, 0.1-0.3 parts of menthol, and 0.1-0.2 parts of sucralose. The Chinese medicine pill has significant effect in treating pharyngitis, good taste, quick effect, small side effects, and is easy to take.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine dripping pill for treating pharyngitis and a preparation method thereof. Background Art

[0002] With the change from autumn to winter, the accelerated pace of modern life, and the increasing pressure from work and life, various colds, bacteria, viruses, and some physical and chemical factors (such as smoking and drinking) can cause inflammation of the pharynx and larynx, forming pharyngitis. As a common upper respiratory tract disease, pharyngitis is mainly manifested by sore throat, dryness, and foreign body sensation. In addition, it is often accompanied by various symptoms such as cough and headache, which seriously affects people's normal life, work and social interaction. If left untreated, it can induce other diseases.

[0003] Currently, a wide variety of medications are used to treat pharyngitis, primarily including antibiotics, anti-inflammatory drugs, and traditional Chinese medicine preparations. The misuse of antibiotics can lead to the growing problem of drug resistance. Traditional anti-inflammatory drugs can also cause gastrointestinal side effects. Traditional Chinese medicine preparations offer unique advantages in treating pharyngitis, but existing preparations still have room for improvement in terms of efficacy and dosage form. For example, traditional Chinese medicine decoctions suffer from drawbacks such as inconvenience, poor taste, and difficulty in storage. It is precisely in this context that traditional Chinese medicine pills have emerged. These are a new type of traditional Chinese medicine preparation with advantages such as rapid onset of action, high bioavailability, ease of administration, and a pleasant taste.

[0004] The existing Chinese medicine drop pills for treating pharyngitis have unreasonable composition and formula, which makes the efficacy less than ideal, slow to take effect, poor taste, poor patient experience, and difficult to adhere to the use. This leads to reduced treatment effect for patients, inability to completely cure, and greatly increased chance of recurrence. For example, the Chinese invention patent with authorization announcement number CN102204971B discloses a Chinese medicine preparation for treating oral and throat diseases and its preparation method, which is prepared from licorice, bitter almonds, radish seeds, platycodon and auxiliary materials, and is mainly used for various common clinical throat discomforts such as acute and chronic pharyngitis, laryngitis, tonsillitis, sore throat, oral inflammation, oral ulcers, dry mouth and bitter taste. Compared with the existing technology, the invention has the effects of clearing away heat and detoxifying, clearing voice and relieving throat, reducing swelling and relieving pain, and is effective in treating oral and throat diseases without side effects, and is safe to take. However, it is slow to take effect, and there is still room for further improvement in efficacy and taste.

[0005] It can be seen that the present invention still needs a Chinese medicine dripping pill for treating pharyngitis which has significant effect, good taste, quick effect, few side effects and is easy to take and a preparation method thereof. Summary of the Invention

[0006] The present invention aims to overcome the deficiencies of the prior art and provide a Chinese medicine dripping pill for treating pharyngitis, which has significant effect, good taste, quick effect, few side effects and is easy to take, and a preparation method thereof.

[0007] To achieve the above-mentioned object, the technical solution adopted by the present invention is: a traditional Chinese medicine pill for treating pharyngitis, comprising the following raw materials in parts by weight: 13-18 parts of Sarcandra scabra, 10-20 parts of Olea europaea, 2-4 parts of Sterculia lycopersicum, 3-5 parts of Arctium lappa, 3-5 parts of Scutellaria baicalensis, 5-7 parts of Licorice, 4-6 parts of Puffball, 4-6 parts of Viola yedoensis, 2-4 parts of Hedyotis diffusa, 3-5 parts of Taraxacum mongolicum, 2-4 parts of Houttuynia cordata, 1-3 parts of Scutellaria barbata, 2-4 parts of Saffron saffron, 1-3 parts of Water celery from Mengzi, 0.3-0.5 parts of Artemisia annua, 0.1-0.3 parts of menthol, and 0.1-0.2 parts of sucralose.

[0008] Preferably, the raw materials for preparing the traditional Chinese medicine pills for treating pharyngitis also include: 5-7 parts of isatis root, 2-4 parts of licorice root, 2-4 parts of plant polysaccharides, 1-3 parts of honey, 2-4 parts of platycodon, 0.5-0.8 parts of truncatum, and 3-6 parts of forsythia.

[0009] Preferably, the plant polysaccharide is a mixture of Tremella fuciformis polysaccharide, Ginkgo biloba polysaccharide and Schisandra chinensis polysaccharide in a mass ratio of 1:(0.8-1.2):(1-2).

[0010] Another object of the present invention is to provide a method for preparing the Chinese medicine dripping pills for treating pharyngitis, comprising the following steps:

[0011] Step S1, mixing Sarcandra scabra, Ophiopogon japonicus, Sterculia lycopersicum, Arctium lappa, Scutellaria baicalensis, Licorice root, Puffball, Viola yedoensis, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Mengzi water celery, Isatis root, Orchidaceae, Platycodon grandiflorum, Nasturtium officinale, and Forsythia suspensa according to weight portions to obtain a mixture, adding the mixture to water for decoction, filtering, and extracting the residue with ethanol; combining the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, and concentrating under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.10-1.20; drying the extract by vacuum drying technology, and pulverizing to obtain an extract powder;

[0012] Step S2: first heat and melt the matrix, then add the extract powder, moxa slices, menthol, sucralose, plant polysaccharides and honey, and stir evenly to obtain a medicinal solution;

[0013] Step S3: using modern Chinese medicine dripping pill technology to obtain the prescribed dripping pills.

[0014] Preferably, the mass ratio of the mixed material, water and ethanol in step S1 is 1:(5-8):(6-10).

[0015] Preferably, the matrix in step S2 is polyethylene glycol 6000.

[0016] Preferably, the mass ratio of the matrix to the extract powder in step S2 is (1.5-3):1.

[0017] Preferably, the decocting temperature in step S1 is 95-98°C.

[0018] Preferably, the extraction in step S1 is performed by heating under reflux, and the extraction is performed twice, each time for 1-2 hours, and the two extracts are combined.

[0019] Due to the application of the above technical solution, the present invention has the following beneficial effects:

[0020] (1) The preparation method of the Chinese medicine dripping pills for treating pharyngitis disclosed in the present invention has simple process, convenient operation, high preparation efficiency and finished product qualification rate, low dependence on equipment, small impact on the environment, and is conducive to industrial continuous production. The prepared dripping pills have high clinical promotion and application value.

[0021] (2) The Chinese medicine pills for treating pharyngitis disclosed in the present invention are made of the following raw materials in parts by weight: 13-18 parts of Sarcandra scabra, 10-20 parts of Olea europaea, 2-4 parts of Sterculia lycopersicum, 3-5 parts of Arctium lappa, 3-5 parts of Scutellaria baicalensis, 5-7 parts of Licorice, 4-6 parts of Puffball, 4-6 parts of Viola yedoensis, 2-4 parts of Hedyotis diffusa, 3-5 parts of Taraxacum mongolicum, 2-4 parts of Houttuynia cordata, 1-3 parts of Scutellaria barbata, 2-4 parts of Saffron saffron, 1-3 parts of Water celery, 0.3-0.5 parts of Artemisia selengensis, 0.1-0.3 parts of Menthol, 0.05 parts of Sucralose. .1-0.2 parts, Radix Isatidis 5-7 parts, Radix Glycyrrhizae 2-4 parts, Plant polysaccharides 2-4 parts, Honey 1-3 parts, Platycodon grandiflorum 2-4 parts, Nasturtium 0.5-0.8 parts, Fructus Forsythiae 3-6 parts; Through the reasonable compatibility of each raw material, the product made can treat pharyngitis with remarkable effect, good taste, quick effect, small side effect and convenient taking; Traditional treatment rules for pharyngitis are mainly based on clearing away heat and detoxifying, while the present invention, on the basis of clearing away heat and detoxifying, focuses on dispersing wind and relieving sore throat, and harmonizing qi and blood, forming a "clearing, dispersing and regulating" trinity treatment rule. The present invention follows the compatibility principle of "monarch, minister, assistant and messenger" of traditional Chinese medicine in formulating the prescription, selects Radix Sarcocarpae, Radix Glycyrrhizae etc. as monarch medicine, clearing away heat and detoxifying, Fructus Arctii, Sterculia lychnophora, Menthol etc. as minister medicine, dispersing wind and relieving sore throat, Radix Glycyrrhizae etc. as assistant and messenger medicine, harmonizes various medicines and enhances drug efficacy, and such compatibility not only conforms to the theory of traditional Chinese medicine, but also has a synergistic effect.

[0022] (3) The Chinese medicine dripping pills for treating pharyngitis disclosed in the present invention incorporate medicinal materials with good efficacy but certain "toxicity" (such as burdock seeds, trollius, and sarcandra) into the formula. By combining them with other medicinal materials, the toxicity is reduced and the efficacy is enhanced. Through the rational design of the formula, the Chinese medicine dripping pills not only target the surface symptoms of pharyngitis (such as redness, swelling, and pain), but also fundamentally treat pharyngitis through multiple target effects such as regulating immunity, inhibiting inflammatory factors, and antibacterial activities.

[0023] (4) The Chinese medicine dripping pills for treating pharyngitis disclosed in the present invention adopt a dripping pill dosage form and have the advantages of rapid onset of action, high bioavailability, convenient administration, and good taste, which significantly improves patient compliance and therapeutic effect. The added plant polysaccharides, sucralose, and honey not only play a role in compatibility and detoxification, but also regulate immune function, improve the taste of the dripping pills, and completely mask the bitter taste of medicinal materials such as Radix Sarcosae; when polyethylene glycol 6000 is used as the matrix, other medicinal materials can be better mixed with polyethylene glycol, and the dripping process is also smoother. The produced dripping pills are round, smooth in surface, and have a stable and controllable pill weight. The dripping speed is also ideal, which can meet the requirements of industrial production.

[0024] (5) The Chinese medicine dripping pills for treating pharyngitis disclosed in the present invention provide a new solution for the treatment of pharyngitis through the scientific nature of the raw material formula, the uniqueness of the treatment principle, the advanced drug dosage form, and the synergistic enhancement of technical effects, which has important clinical significance and market value. DETAILED DESCRIPTION

[0025] The following description is intended to disclose the present invention so that those skilled in the art can implement the present invention. The preferred embodiments described below are merely examples, and those skilled in the art may conceive of other obvious variations.

[0026] Example 1

[0027] A traditional Chinese medicine dripping pill for treating pharyngitis is prepared from the following raw materials in parts by weight: 13 parts of Sarcandra scabra, 10 parts of Oleander, 2 parts of Sterculia lycopersicum, 3 parts of Arctium lappa, 3 parts of Scutellaria baicalensis, 5 parts of Licorice, 4 parts of Puffball, 4 parts of Viola yedoensis, 2 parts of Hedyotis diffusa, 3 parts of Taraxacum mongolicum, 2 parts of Houttuynia cordata, 1 part of Scutellaria barbata, 2 parts of Crocus sativus, 1 part of Water celery, 0.3 parts of Artemisia selengensis leaf, 0.1 parts of menthol, and 0.1 parts of sucralose; the polyethylene glycol is polyethylene glycol 6000.

[0028] The raw materials for preparing the Chinese medicine dripping pills for treating pharyngitis also include: 5 parts of isatis root, 2 parts of licorice root, 2 parts of plant polysaccharides, 1 part of honey, 2 parts of platycodon, 0.5 parts of trollius, and 3 parts of forsythia; the plant polysaccharides are a mixture of tremella polysaccharide, ginkgo leaf polysaccharide, and schisandra chinensis polysaccharide in a mass ratio of 1:0.8:1.

[0029] A method for preparing the Chinese medicine dripping pills for treating pharyngitis comprises the following steps:

[0030] Step S1, mixing Sarcandra scabra, Ophiopogon japonicus, Sterculia lycopersicum, Arctium lappa, Scutellaria baicalensis, Licorice root, Puffball, Viola yedoensis, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Saffron, Mengzi water celery, Isatis root, Orchidaceae, Platycodon grandiflorum, Nasturtium, and Forsythia suspensa according to weight portions to obtain a mixture, adding the mixture to water for decoction, filtering, and extracting the residue with ethanol; combining the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, and concentrating under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.10; drying the extract by vacuum drying technology, and pulverizing to obtain an extract powder;

[0031] Step S2: first heat and melt the matrix, then add the extract powder, moxa slices, menthol, sucralose, plant polysaccharides and honey, and stir evenly to obtain a medicinal solution;

[0032] Step S3: using modern Chinese medicine dripping pill technology to obtain the prescribed dripping pills.

[0033] The mass ratio of the mixed material, water, and ethanol in step S1 is 1:5:6; the decoction temperature in step S1 is 95° C.; the extraction in step S1 is heating reflux extraction, extracted twice, each time for 1 hour, and the two extracts are combined; the matrix in step S2 is polyethylene glycol 6000; the mass ratio of the matrix to the extract powder in step S2 is 2:1.

[0034] Example 2

[0035] A traditional Chinese medicine dripping pill for treating pharyngitis is prepared from the following raw materials in parts by weight: 14 parts of Sarcandra scabra, 12 parts of Oleander, 2.5 parts of Sterculia lycopersicum, 3.5 parts of Arctium lappa, 3.5 parts of Scutellaria baicalensis, 5.5 parts of Licorice, 4.5 parts of Puffball, 4.5 parts of Viola yedoensis, 2.5 parts of Hedyotis diffusa, 3.5 parts of Taraxacum mongolicum, 2.5 parts of Houttuynia cordata, 1.5 parts of Scutellaria barbata, 2.5 parts of Crocus saffron, 1.5 parts of Oenothera japonica, 0.35 parts of Artemisia selengensis tablets, 0.15 parts of menthol, and 0.12 parts of sucralose; the polyethylene glycol is polyethylene glycol 6000.

[0036] The raw materials for preparing the traditional Chinese medicine pills for treating pharyngitis also include: 5.5 parts of isatis root, 2.5 parts of licorice root, 2.5 parts of plant polysaccharides, 1.5 parts of honey, 2.5 parts of platycodon, 0.6 part of trollius, and 4 parts of forsythia; the plant polysaccharides are a mixture of tremella polysaccharide, ginkgo leaf polysaccharide, and Schisandra chinensis polysaccharide in a mass ratio of 1:0.9:1.2.

[0037] A method for preparing the Chinese medicine dripping pills for treating pharyngitis comprises the following steps:

[0038] Step S1, mixing Sarcandra scabra, Ophiopogon japonicus, Sterculia lycopersicum, Arctium lappa, Scutellaria baicalensis, Licorice root, Puffball, Viola yedoensis, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Mengzi water celery, Isatis root, Orchidaceae, Platycodon grandiflorum, Nasturtium officinale, and Forsythia suspensa according to weight portions to obtain a mixture, adding the mixture to water for decoction, filtering, and extracting the residue with ethanol; combining the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, and concentrating under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.13; drying the extract by vacuum drying technology, and pulverizing to obtain an extract powder;

[0039] Step S2: first heat and melt the matrix, then add the extract powder, moxa slices, menthol, sucralose, plant polysaccharides and honey, and stir evenly to obtain a medicinal solution;

[0040] Step S3: using modern Chinese medicine dripping pill technology to obtain the prescribed dripping pills.

[0041] The mass ratio of the mixed material, water, and ethanol in step S1 is 1:6:7; the decoction temperature in step S1 is 96° C.; the extraction in step S1 is heating reflux extraction, extracted twice, each time for 1.2 hours, and the two extracts are combined; the matrix in step S2 is polyethylene glycol 6000; the mass ratio of the matrix to the extract powder in step S2 is 2:1.

[0042] Example 3

[0043] A traditional Chinese medicine dripping pill for treating pharyngitis is prepared from the following raw materials in parts by weight: 16 parts of Sarcandra scabra, 15 parts of Oleander, 3 parts of Sterculia lycopersicum, 4 parts of Arctium lappa, 4 parts of Scutellaria baicalensis, 6 parts of Licorice, 5 parts of Puffball, 5 parts of Viola yedoensis, 3 parts of Hedyotis diffusa, 4 parts of Taraxacum mongolicum, 3 parts of Houttuynia cordata, 2 parts of Scutellaria barbata, 3 parts of Saffron, 2 parts of Oenothera japonica, 0.4 parts of Artemisia selengensis, 0.2 parts of menthol, and 0.15 parts of sucralose; the polyethylene glycol is polyethylene glycol 6000.

[0044] The raw materials for preparing the traditional Chinese medicine dripping pills for treating pharyngitis also include: 6 parts of isatis root, 3 parts of licorice root, 3 parts of plant polysaccharides, 2 parts of honey, 3 parts of platycodon, 0.65 parts of trollius, and 4.5 parts of forsythia; the plant polysaccharides are prepared by mixing tremella polysaccharide, ginkgo leaf polysaccharide, and schisandra chinensis polysaccharide in a mass ratio of 1:1:1.5.

[0045] A method for preparing the Chinese medicine dripping pills for treating pharyngitis comprises the following steps:

[0046] Step S1, mixing Sarcandra scabra, Ophiopogon japonicus, Sterculia lycopersicum, Arctium lappa, Scutellaria baicalensis, Licorice root, Puffball, Viola yedoensis, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Mengzi water celery, Isatis root, Orchidaceae, Platycodon grandiflorum, Nasturtium officinale, and Forsythia suspensa according to weight portions to obtain a mixture, adding the mixture to water for decoction, filtering, and extracting the residue with ethanol; combining the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, and concentrating under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.15; drying the extract by vacuum drying technology, and pulverizing to obtain an extract powder;

[0047] Step S2: first heat and melt the matrix, then add the extract powder, moxa slices, menthol, sucralose, plant polysaccharides and honey, and stir evenly to obtain a medicinal solution;

[0048] Step S3: using modern Chinese medicine dripping pill technology to obtain the prescribed dripping pills.

[0049] The mass ratio of the mixed material, water, and ethanol in step S1 is 1:6.5:8; the decoction temperature in step S1 is 97° C.; the extraction in step S1 is heating reflux extraction, extracted twice, each time for 1.5 hours, and the two extracts are combined; the matrix in step S2 is polyethylene glycol 6000; the mass ratio of the matrix to the extract powder in step S2 is 2:1.

[0050] Example 4

[0051] A traditional Chinese medicine dripping pill for treating pharyngitis is prepared from the following raw materials in parts by weight: 17 parts of Sarcandra scabra, 18 parts of Oleander, 3.5 parts of Sterculia lycopersicum, 4.5 parts of Arctium lappa, 4.5 parts of Scutellaria baicalensis, 6.5 parts of Licorice, 5.5 parts of Puffball, 5.5 parts of Viola yedoensis, 3.5 parts of Hedyotis diffusa, 4.5 parts of Taraxacum mongolicum, 3.5 parts of Houttuynia cordata, 2.5 parts of Scutellaria barbata, 3.5 parts of Saffron saffron, 2.5 parts of Water celery, 0.45 parts of Artemisia selengensis, 0.25 parts of menthol, and 0.18 parts of sucralose; the polyethylene glycol is polyethylene glycol 6000.

[0052] The raw materials for preparing the traditional Chinese medicine pills for treating pharyngitis also include: 6.5 parts of isatis root, 3.5 parts of licorice root, 3.5 parts of plant polysaccharides, 2.5 parts of honey, 3.5 parts of platycodon, 0.75 parts of trollius, and 5.5 parts of forsythia; the plant polysaccharides are a mixture of tremella polysaccharide, ginkgo leaf polysaccharide, and Schisandra chinensis polysaccharide in a mass ratio of 1:1.1:1.8.

[0053] A method for preparing the Chinese medicine dripping pills for treating pharyngitis comprises the following steps:

[0054] Step S1, mixing Sarcandra scabra, Ophiopogon japonicus, Sterculia lycopersicum, Arctium lappa, Scutellaria baicalensis, Licorice root, Puffball, Viola yedoensis, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Saffron, Mengzi water celery, Isatis root, Orchidaceae, Platycodon grandiflorum, Nasturtium, and Forsythia suspensa according to weight portions to obtain a mixture, adding the mixture to water for decoction, filtering, and extracting the residue with ethanol; combining the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, concentrating under reduced pressure to recover ethanol and water, and obtaining an extract with a relative density of 1.18; drying the extract by vacuum drying technology, and crushing to obtain an extract powder;

[0055] Step S2, first heating and melting the matrix, then adding the extract powder, moxa slices, menthol, sucralose, plant polysaccharides and honey, and stirring evenly to obtain a medicinal solution;

[0056] Step S3: using modern Chinese medicine dripping pill technology to obtain the prescribed dripping pills.

[0057] The mass ratio of the mixed material, water, and ethanol in step S1 is 1:7.5:9.5; the decoction temperature in step S1 is 97.5°C; the extraction in step S1 is heating reflux extraction, extracted twice, each time for 1.8 hours, and the two extracts are combined; the matrix in step S2 is polyethylene glycol 6000; the mass ratio of the matrix to the extract powder in step S2 is 2:1.

[0058] Example 5

[0059] A traditional Chinese medicine dripping pill for treating pharyngitis is prepared from the following raw materials in parts by weight: 18 parts of Sarcandra scabra, 20 parts of Oleander, 4 parts of Sterculia lycopersicum, 5 parts of Arctium lappa, 5 parts of Scutellaria baicalensis, 7 parts of Licorice, 6 parts of Puffball, 6 parts of Viola yedoensis, 4 parts of Hedyotis diffusa, 5 parts of Taraxacum mongolicum, 4 parts of Houttuynia cordata, 3 parts of Scutellaria barbata, 4 parts of Crocus saffron, 3 parts of Water celery, 0.5 parts of Artemisia selengensis leaf, 0.3 parts of menthol, and 0.2 parts of sucralose; the polyethylene glycol is polyethylene glycol 6000.

[0060] The raw materials for preparing the Chinese medicinal pills for treating pharyngitis also include: 7 parts of isatis root, 4 parts of licorice root, 4 parts of plant polysaccharides, 3 parts of honey, 4 parts of platycodon, 0.8 parts of trollius, and 6 parts of forsythia; the plant polysaccharides are prepared by mixing tremella polysaccharide, ginkgo leaf polysaccharide, and schisandra chinensis polysaccharide in a mass ratio of 1:1.2:2.

[0061] A method for preparing the Chinese medicine dripping pills for treating pharyngitis comprises the following steps:

[0062] Step S1, mixing Sarcandra scabra, Ophiopogon japonicus, Sterculia lycopersicum, Arctium lappa, Scutellaria baicalensis, Licorice, Puffball, Viola yedoensis, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Saffron, Mengzi Water celery, Isatis root, Orchidaceae, Platycodon grandiflorum, Nasturtium, and Forsythia suspensa according to weight portions to obtain a mixture, adding the mixture to water for decoction, filtering, and extracting the residue with ethanol; combining the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, concentrating under reduced pressure to recover ethanol and water, and obtaining an extract with a relative density of 1.20; drying the extract by vacuum drying technology, and pulverizing to obtain an extract powder;

[0063] Step S2, first heating and melting the matrix, then adding the extract powder, moxa slices, menthol, sucralose, plant polysaccharides and honey, and stirring evenly to obtain a medicinal solution;

[0064] Step S3: using modern Chinese medicine dripping pill technology to obtain the prescribed dripping pills.

[0065] The mass ratio of the mixed material, water, and ethanol in step S1 is 1:8:10; the decoction temperature in step S1 is 98° C.; the extraction in step S1 is heating reflux extraction, extracted twice, each time for 2 hours, and the two extracts are combined; the matrix in step S2 is polyethylene glycol 6000; the mass ratio of the matrix to the extract powder in step S2 is 2:1.

[0066] Comparative Example 1

[0067] A traditional Chinese medicine pill for treating pharyngitis and a preparation method thereof are basically the same as those in Example 1, except that plant polysaccharides, Mengzi water celery and saffron are not added.

[0068] Comparative Example 2

[0069] A traditional Chinese medicine pill for treating pharyngitis and a preparation method thereof are substantially the same as those in Example 1, except that Scutellaria barbata, Arctium lappa and Puffball are not added.

[0070] Comparative Example 3

[0071] A traditional Chinese medicine pill for treating pharyngitis and a preparation method thereof are substantially the same as those in Example 1, except that an equal amount of Sarcandra scabra is used instead of Rhizoma Cyperi.

[0072] Comparative Example 4

[0073] A traditional Chinese medicine pill for treating pharyngitis and a preparation method thereof are basically the same as those in Example 1, except that an equal amount of Oleracea chinensis is used instead of Sarcandra scabra.

[0074] In order to further illustrate the beneficial technical effects of the Chinese medicinal pills for treating pharyngitis involved in each embodiment of the present invention, relevant performance tests were conducted on the Chinese medicinal pills for treating pharyngitis involved in Examples 1-5 and Comparative Examples 1-4, and the test methods are as follows:

[0075] (1) Clinical data

[0076] The present invention takes acute and chronic pharyngitis as an example, collects 270 cases from the society for clinical observation, and divides them into 9 groups, corresponding to Examples 1-5 and Comparative Examples 1-4 respectively. Select TCM diagnosis of acute and chronic pharyngitis as the standard.

[0077] Symptoms of acute pharyngitis: In the early stages of acute pharyngitis, the throat may feel dry and burning, which gradually develops into pain. Sometimes even swallowing saliva can cause sore throat discomfort. Some patients also experience fever and headaches. The discomfort can also lead to loss of appetite and inability to eat. There may also be soreness in the limbs.

[0078] Symptoms of chronic pharyngitis: The main symptoms are discomfort in the throat, as well as dryness, itching, and swelling. Chronic pharyngitis can cause increased secretions, burning and pain, and can easily lead to retching. Even brushing your teeth or walking too fast can cause retching. Sometimes, if you don't drink enough water, you'll feel a foreign body sensation in your throat, which you can't cough out but can't swallow. Talking too much can make this dry, itchy, and foreign body sensation worse.

[0079] Finally, each group included 6 patients with acute pharyngitis (5 males and 1 female) and 24 patients with chronic pharyngitis (18 males and 6 females). None of them had other serious diseases, and their average age was 43 years.

[0080] Efficacy assessment:

[0081] 1) Significant effects: The burning and pain in the throat are significantly relieved, fever, headache, and sore limbs are significantly improved, and the symptoms of dry, itchy and swollen throat are greatly improved.

[0082] 2) Effective: Sore throat is relieved, dry throat, itchiness and swelling are improved.

[0083] 3) Ineffective: The symptoms of acute and chronic pharyngitis are not alleviated, and may even be aggravated.

[0084] 4) Adverse reactions: diarrhea, vomiting and other adverse reactions after taking the drug.

[0085] During the clinical trial, other medications and health supplements were discontinued for comparison. Patients were observed for 14 days using this specification of dripping pills, which constituted a course of treatment. Dosage: 3 times daily, 4 pills each time, 0.5g per pill. Clinical trial results are shown in Tables 1-2. Table 1 shows the clinical trial results of Example 1 of the present invention, and Table 2 shows the effective rates calculated based on the statistical results of each clinical trial.

[0086] Table 1 Clinical trial results of the product of Example 1

[0087]

[0088] As can be seen from Table 1, among the 30 patients in the clinical trial of Example 1, 21 had significant effects, 9 had some effects, and 0 had no effects. No adverse reactions occurred, and no patients developed psychological resistance to taking the drug. The total effective rate was 100%.

[0089] Table 2 Clinical trial efficacy

[0090]

[0091] As can be seen from Table 2, the Chinese medicine pills for treating pharyngitis involved in the embodiments of the present invention have better therapeutic effects than the comparative products; the combined use of plant polysaccharides, Mengzi water celery, saffron, Scutellaria barbata, burdock fruit, puffball, golden fruit olive and swollen knotweed is beneficial to improving the above performance.

[0092] The above embodiments are only for illustrating the technical concept and features of the present invention. Their purpose is to enable people familiar with this technology to understand the content of the present invention and implement it accordingly. They are not intended to limit the scope of protection of the present invention. Any equivalent changes or modifications made according to the spirit of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese medicine dripping pill for treating pharyngitis, characterized in that: The invention is prepared from the following raw materials in parts by weight: 13-18 parts of Sarcandra scabra, 10-20 parts of Olea europaea, 2-4 parts of Sterculia lycopersicum, 3-5 parts of Arctium lappa, 3-5 parts of Scutellaria baicalensis, 5-7 parts of Licorice, 4-6 parts of Puffball, 4-6 parts of Viola yedoensis, 2-4 parts of Hedyotis diffusa, 3-5 parts of Taraxacum mongolicum, 2-4 parts of Houttuynia cordata, 1-3 parts of Scutellaria barbata, 2-4 parts of Saffron saffron, 1-3 parts of Water celery from Mengzi, 0.3-0. 5 parts, menthol 0.1-0.3 parts, sucralose 0.1-0.2 parts, isatis root 5-7 parts, ganqingqinglan 2-4 parts, plant polysaccharide 2-4 parts, honey 1-3 parts, platycodon 2-4 parts, nasturtium 0.5-0.8 parts, forsythia suspensa 3-6 parts; the plant polysaccharide is a mixture of tremella polysaccharide, ginkgo leaf polysaccharide and schisandra chinensis polysaccharide in a mass ratio of 1: (0.8-1.2): (1-2).

2. A method for preparing the Chinese medicine dripping pills for treating pharyngitis according to claim 1, characterized in that: The steps include: Step S1, mixing Sarcandra scabra, Ophiopogon japonicus, Sterculia lycopersicum, Arctium lappa, Scutellaria baicalensis, Licorice root, Puffball, Viola yedoensis, Hedyotis diffusa, Taraxacum mongolicum, Houttuynia cordata, Scutellaria barbata, Crocus sativus, Mengzi water celery, Isatis root, Orchidaceae, Platycodon grandiflorum, Nasturtium officinale, and Forsythia suspensa according to weight portions to obtain a mixture, adding the mixture to water for decoction, filtering, and extracting the residue with ethanol; combining the medicinal liquid obtained by filtering after decoction with the medicinal liquid obtained by filtering after ethanol extraction, and concentrating under reduced pressure to recover ethanol and water to obtain an extract with a relative density of 1.10-1.20; drying the extract by vacuum drying technology, and pulverizing to obtain an extract powder; Step S2: first heat and melt the matrix, then add the extract powder, moxa slices, menthol, sucralose, plant polysaccharides and honey, and stir evenly to obtain a medicinal solution; Step S3: obtaining the dropping pills using a modern Chinese medicine dropping pill preparation process.

3. The method for preparing the Chinese medicinal pills for treating pharyngitis according to claim 2, wherein: The mass ratio of the mixed material, water and ethanol in step S1 is 1:(5-8):(6-10).

4. The method for preparing the Chinese medicinal pills for treating pharyngitis according to claim 2, wherein: The matrix is ​​polyethylene glycol 6000.

5. The method for preparing the Chinese medicinal pills for treating pharyngitis according to claim 2, wherein: The mass ratio of the matrix to the extract powder is (1.5-3):

1.

6. The method for preparing the Chinese medicinal pills for treating pharyngitis according to claim 2, wherein: The decoction temperature in step S1 is 95-98°C.

7. The method for preparing the Chinese medicinal pills for treating pharyngitis according to claim 2, wherein: The ethanol extraction in step S1 is performed by heating under reflux, and the extraction is performed twice, each time for 1-2 hours, and the two extracts are combined.

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