Traditional Chinese veterinary medicine composition for treating aflatoxin poisoning

Abstract

The invention belongs to the technical field of aflatoxin poisoning treatment, and particularly relates to a traditional Chinese veterinary medicine composition for treating aflatoxin poisoning, which comprises 7% of coptis chinensis, 7% of golden cypress, 7% of liquorice, 7% of rhizoma atractylodis, 6% of scutellaria baicalensis, 4% of gardenia, 5% of radices trichosanthis, 12% of radices trichosanthis, 5% of rheum officinale, 5% of radix bupleuri, 6% of radix glehniae, 6% of radix ophiopogonis, 9% of talc, 6% of radix sophorae flavescentis and 8% of rhizoma alismatis. The powder is prepared from coptis chinensis, golden cypress, liquorice, rhizoma atractylodis, scutellaria baicalensis, cape jasmine, radix trichosanthis, radix trichosanthis, rheum officinale, radix bupleuri, radix glehniae, radix ophiopogonis, talc, radix sophorae flavescentis and rhizoma alismatis, the coptis chinensis is bitter and cold, can enter heart, liver, gallbladder, stomach and large intestine meridians, has the effects of clearing heat, drying dampness, purging fire and removing toxin, has the functions of clearing intestines, stopping diarrhea, calming liver and improving eyesight, has a very strong inhibition effect on various germs, and can be used for preparing the traditional Chinese medicine preparation for treating chronic bronchitis. The white blood cell phagocytic ability can be enhanced, the effects of benefiting gallbladder, reducing blood pressure and relieving spasm and pain are achieved, and gastrointestinal mucosa is protected; artemisia capillaris is bitter, pungent and slightly cold, enters spleen, stomach and liver meridians, and has the effects of clearing damp-heat, removing jaundice and promoting urination.

Description

Technical Field

[0001] The present invention belongs to the technical field of treating aflatoxin poisoning, and particularly relates to a traditional Chinese veterinary medicine composition for treating aflatoxin poisoning. Background Art

[0002] Aflatoxin is a compound with strong biological toxicity, often produced by Aspergillus flavus, Aspergillus parasiticus and several other molds in moldy grains such as rice, beans, peanuts, etc., and is the strongest carcinogen so far. Food crops can be contaminated before and after harvest. Pre-harvest contamination of aflatoxin is mainly limited to corn, cottonseed, peanuts and tree nuts. Post-harvest contamination can occur in various other crops such as coffee, rice and spices. Animal feed, under conditions favorable for mold growth (warm and humid storage environment), improper storage usually leads to much higher contamination levels than those found in the field. High doses of aflatoxin can cause acute poisoning (aflatoxin poisoning) and can be life-threatening, usually by damaging the liver. Since the 1960s, outbreaks of acute liver failure (jaundice, lethargy, nausea, death) have been observed in the population and have been identified as aflatoxin poisoning. In poultry, the effects of aflatoxin include liver damage, impaired fertility and reproductive efficiency, decreased egg production, poor eggshell quality, poor carcass quality and increased disease susceptibility. Pigs are also highly affected by aflatoxin, and chronic effects are largely manifested as liver damage. The main symptoms of the effects on cattle are reduced weight gain and liver and kidney damage; milk production is also reduced.

[0003] For the aflatoxin poisoning of livestock and poultry, using human mycotoxin removers for detoxification has problems such as too high cost or easy to cause meat food safety risks. Therefore, there is currently no commercial aflatoxin antidote for veterinary use, and the prevention of aflatoxin poisoning in animals is still the main focus. Although the existing treatment agents have a certain liver protection effect, their ability to remove aflatoxin is limited and they cannot achieve a real detoxification effect. Summary of the Invention

[0004] To solve the problems raised in the above background art. The present invention provides a traditional Chinese veterinary medicine composition for treating aflatoxin poisoning, which has the characteristics of low cost, safety and no risk of meat food safety.

[0005] To achieve the above object, the present invention provides the following technical solution: A traditional Chinese veterinary medicine composition for treating aflatoxin poisoning, comprising 7% Coptis chinensis, 7% Phellodendron amurense, 7% Glycyrrhiza uralensis, 7% Atractylodes lancea, 6% Scutellaria baicalensis, 4% Gardenia jasminoides, 5% Trichosanthes kirilowii, 12% Trichosanthes kirilowii, 5% Rheum officinale, 5% Bupleurum chinense, 6% Glehnia littoralis, 6% Ophiopogon japonicus, 9% Talc, 6% Sophora flavescens and 8% Alisma orientale.

[0006] Preferably, the powder is prepared from coptis root, phellodendron, liquorice, atractylodes, scutellaria, gardenia, radix trichosanthis, radix trichosanthis, rhubarb, bupleurum, adenophora, ophiopogon, talc, sophora flavescens and orientalis.

[0007] Preferably, a method for preparing a Chinese veterinary medicine composition for treating aflatoxin poisoning comprises the following steps:

[0008] Step 1: Weigh the raw materials according to the proportion, wash, remove impurities, and dry;

[0009] Step 2: Use the crushing equipment to preliminarily crush the API, and then use the ultra-micro wall breaking technology to finely crush it;

[0010] Step 3: Use a sealed bag to pack and seal for later use.

[0011] Preferably, the weight of each sealed bag of powder packaged in step 4 is 100 g.

[0012] Preferably, in the step 2, the raw material drug is crushed and then sieved using a 300-mesh sieve.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] 1. In the present invention, Coptis chinensis is bitter and cold, enters the heart, liver, gallbladder, stomach and large intestine meridians, has the effects of clearing away heat and dampness, purging fire and detoxifying, has the functions of clearing intestines and stopping diarrhea, calming the liver and improving eyesight, has a strong inhibitory effect on various pathogens, and can enhance the phagocytic ability of leukocytes, has the effects of promoting bile secretion, lowering blood pressure, relieving acute pain and protecting gastrointestinal mucosa; Artemisia capillaris is bitter, pungent, slightly cold, enters the spleen, stomach and liver meridians, clears damp heat, relieves jaundice and promotes diuresis; Gardenia jasminoides is bitter and cold, enters the heart, liver, spleen, stomach and triple burner meridians, clears away heat and purges fire, promotes dampness and detoxifies, cools blood and stops bleeding; Licorice is sweet and flat, enters the heart, spleen, stomach and liver meridians, clears away heat and detoxifies, relieves acute pain and stops pain, and the glycyrrhizin in its components has a strong detoxifying effect, has a good effect on food, drug, pesticide poisoning, snake venom, poisoning by metabolites in the body, allergic diseases, etc., and the four medicines are used together to clear away heat and detoxify, protect the liver and protect the kidneys as the main medicine.

[0015] 2. In the present invention, Atractylodes macrocephala is pungent, bitter, warm, enters the spleen and stomach meridians, dries dampness and strengthens the spleen, and is used together with Phellodendron chinense to form the effects of clearing away heat and detoxifying, strengthening the spleen and transporting dampness; Radix Trichosanthis is sweet, bitter, slightly cold, enters the lung and stomach meridians, reduces fire and moisturizes dryness, promotes the production of body fluid and quenches thirst, discharges pus and reduces swelling; Glehnia littoralis and Radix Ophiopogonis are sweet, slightly cold, enter the heart, lung and stomach meridians, clear the heart and moisten the lungs, nourish the stomach and produce body fluid, promote diuresis and relieve stranguria, have similar effects of fluid invigoration and cardiotonic, can protect the gastrointestinal tract, clear toxins, and improve the body's resistance. The five medicines work together to strengthen the heart and replenish fluids, nourish the gastrointestinal tract, and improve the body's resistance and tolerance to mycotoxins, and jointly assist the main medicine in detoxification and detoxification as auxiliary medicines.

[0016] 3. In the present invention, Scutellaria baicalensis is bitter and cold, entering the lung, gallbladder, spleen, and stomach meridians, clearing heat and drying dampness, purging fire and detoxifying; Rheum palmatum is bitter and cold, entering the spleen, stomach, large intestine, liver, and pericardium meridians, working together with Scutellaria baicalensis to treat both the upper and lower parts, clearing heat and promoting qi movement, activating blood circulation and removing stasis, and repairing the damage caused by toxins to the body; Bupleurum chinense is bitter, pungent, and slightly cold, entering the liver and gallbladder meridians, soothing the liver and relieving depression to make it unobstructed, and promoting the flow of qi and enhancing the efficacy of the medicine by lifting yang qi, both serving as assistant drugs. Talc is sweet, bland, and cold, entering the stomach, kidney, and bladder meridians, clearing heat and removing dampness, promoting diuresis and relieving stranguria, restoring the function of water metabolism. Sophora flavescens is bitter and cold, belonging to the heart, liver, stomach, large intestine, and bladder meridians, clearing heat and drying dampness, killing insects, and promoting diuresis. Alisma orientale is sweet, bland, and cold, belonging to the kidney and bladder meridians, promoting diuresis and percolating dampness, clearing heat and purging fire, and reducing turbidity and lipid, facilitating the timely excretion of the detoxified and degraded toxins of the above herbs as the guiding drug, enhancing the body's resistance and tolerance to mycotoxins, assisting the main drug in detoxifying and expelling toxins together. By using Chinese herbal medicines for detoxification, the purpose of low cost, safety, and no risk to meat food safety can be achieved. Detailed implementation manners

[0017] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0018] Embodiment 1

[0019] The present invention provides the following technical solution: A traditional Chinese veterinary medicine composition for treating aflatoxin poisoning, comprising 7% Coptis chinensis, 7% Phellodendron amurense, 7% Glycyrrhiza uralensis, 7% Atractylodes lancea, 6% Scutellaria baicalensis, 4% Gardenia jasminoides, 5% Trichosanthes kirilowii, 12% Trichosanthes kirilowii, 5% Rheum palmatum, 5% Bupleurum chinense, 6% Glehnia littoralis, 6% Ophiopogon japonicus, 9% Talc, 6% Sophora flavescens, and 8% Alisma orientale.

[0020] Specifically, a powder prepared from Coptis chinensis, Phellodendron amurense, Glycyrrhiza uralensis, Atractylodes lancea, Scutellaria baicalensis, Gardenia jasminoides, Trichosanthes kirilowii, Trichosanthes kirilowii, Rheum palmatum, Bupleurum chinense, Glehnia littoralis, Ophiopogon japonicus, Talc, Sophora flavescens, and Alisma orientale. By using Coptis chinensis, Glycyrrhiza uralensis, Artemisia capillaris, and Gardenia jasminoides, it can relieve spasm and pain, protect the gastrointestinal mucosa, treat allergic diseases, etc., have a strong inhibitory effect on a variety of pathogens, and at the same time can clear heat and purge fire, promote diuresis and detoxify. The combination of these four herbs works together to clear heat and detoxify. The combination of Atractylodes lancea and Phellodendron amurense forms the effect of clearing heat and detoxifying, strengthening the spleen and promoting the transportation of dampness. By using Glehnia littoralis, Ophiopogon japonicus, Scutellaria baicalensis, Rheum palmatum, Bupleurum chinense, Talc, Sophora flavescens, and Alisma orientale as auxiliary drugs, it can enhance the body's resistance and tolerance to mycotoxins, and assist the main drug in detoxifying and expelling toxins together.

[0021] Specifically, a preparation method of a traditional Chinese veterinary medicine composition for treating aflatoxin poisoning comprises the following steps:

[0022] Step 1: Weigh the raw materials according to the ratio, wash them, remove impurities, and dry them.

[0023] Step 2: Initially crush the bulk drug through a crushing device, and then conduct fine crushing using ultramicro cell wall breaking technology;

[0024] Step 3: Use a sealed bag for packaging and sealing for later use.

[0025] Specifically, the weight of the powder in each sealed bag for packaging in Step 4 is 100 g.

[0026] Specifically, after crushing the bulk drug in Step 2, it is screened using a 300-mesh sieve.

[0027] The working principle and usage process of the present invention: When administering the medicine in the present invention, administer the corresponding amount of medicine according to the animal body size. For example, for calves, the dosage is 150 - 200 g each time, for growing cattle, it is 200 - 300 g each time, and for adult cattle, it is 300 - 400 g each time. It is administered twice a day, in the morning and evening. The powder is brewed with warm boiled water and administered using a medicine feeding bottle.

[0028] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions described in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A Chinese veterinary medicine composition for treating aflatoxin poisoning, characterized in that: Including 7% Coptis chinensis, 7% Phellodendron chinense, 7% Licorice, 7% Atractylodes lancea, 6% Scutellaria baicalensis, 4% Gardenia jasminoides, 5% Radix Trichosanthis, 12% Radix Trichosanthis, 5% Rhubarb, 5% Bupleurum, 6% Adenophora acuta, 6% Ophiopogon japonicus, 9% Talc, 6% Sophora flavescens and 8% Alisma orientalis.

2. A Chinese veterinary medicine composition for treating aflatoxin poisoning according to claim 1, characterized in that: A powder prepared from coptis root, phellodendron, liquorice, atractylodes, scutellaria, gardenia, radix trichosanthis, radix trichosanthis, rhubarb, bupleurum, adenophora, ophiopogon, talc, sophora flavescens and orientalis.

3. A method for preparing a Chinese veterinary medicine composition for treating aflatoxin poisoning according to any one of claims 1-2, characterized in that: The following steps are involved: Step 1: Weigh the raw materials according to the proportion, wash, remove impurities, and dry; Step 2: Use the crushing equipment to preliminarily crush the API, and then use the ultra-micro wall breaking technology to finely crush it; Step 3: Use a sealed bag to pack and seal for later use.

4. The method for preparing a Chinese veterinary medicine composition for treating aflatoxin poisoning according to claim 3, characterized in that: The weight of each sealed bag of powder packaged in step 4 is 100 g.

5. The method for preparing a Chinese veterinary medicine composition for treating aflatoxin poisoning according to claim 3, characterized in that: In the step 2, the raw material drug is crushed and then sieved using a 300-mesh sieve.