Traditional Chinese medicine preparation for improving immunity and preparation method thereof

Abstract

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine preparation for improving immunity and a preparation method thereof. The traditional Chinese medicine preparation is prepared from the following raw materials in parts by weight: 10-18 parts of red ginseng, 8-15 parts of rhodomyrtus tomentosa roots, 5-10 parts of Chinese wolfberry fruits, 1-5 parts of red-heart grass, 2-5 parts of radix angelicae, 2-5 parts of radix polygonati officinalis, 3-10 parts of roses, 1-5 parts of red dates and 1-3 parts of brown sugar. The traditional Chinese medicine preparation has the effect of enhancing immune organs, phagocytosis coefficients and ConA-induced splenic lymphocyte transformation capability of normal mice.

Description

Technical Field

[0001] The present invention belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine preparation for enhancing immunity and its preparation method. Background Art

[0002] Sub-health refers to a state of the human body between health and disease, manifested as a decrease in vitality, a decline in function and adaptability within a certain period of time, but not yet reaching the diagnostic criteria for diseases. This state may involve multiple aspects such as physiology, psychology, and social adaptation, and is specifically manifested as symptoms such as fatigue, insomnia, mood swings, memory decline, and low immunity. Low immunity means that the function of the human immune system is weakened, resulting in a decrease in the body's defense ability against external pathogens (such as bacteria, viruses), and a weakening of the monitoring and clearance ability of internal abnormal cells (such as cancer cells).

[0003] Traditional Chinese medicine believes that low immunity is closely related to insufficient healthy qi. Healthy qi is the ability of the human body to resist external pathogens and maintain health, and its strength depends on the functions of the zang-fu organs (especially the spleen, lungs, and kidneys) and the state of qi and blood. Traditional Chinese medicine emphasizes "strengthening healthy qi and consolidating the root", and enhances immunity by regulating the functions of the zang-fu organs and tonifying qi and blood. However, traditional Chinese medicine is difficult to extract, easy to decompose, and is prone to undergo the first-pass effect in the liver and decomposition in the gastrointestinal tract when taken orally, resulting in slow efficacy. There are many traditional Chinese medicines with immune-enhancing effects, such as ginseng, bird's nest, wolfberry fruit, angelica, almond, pilose antler, curculigo rhizome, etc., but single herbs usually can only control or relieve certain symptoms, and there are defects such as poor curative effects. Traditional Chinese medicine compound preparations achieve synergistic effects among various herbs through the theory of compatibility of monarch, minister, assistant, and guide herbs in traditional Chinese medicine, and thus achieve effects such as improving curative effects and reducing toxic and side effects. This is the main development direction of future traditional Chinese medicine compound preparations.

[0004] Common prescriptions for strengthening healthy qi and consolidating the root include Sijunzi Decoction, Liuwei Dihuang Pills, etc. "Sijunzi Decoction" is a basic prescription for replenishing qi, which can improve the phagocytic ability of macrophages and is used to treat qi deficiency of the spleen and stomach, yin deficiency with internal heat, and is not suitable for those with abdominal distension; "Liuwei Dihuang Pills" is a prescription for nourishing yin, which can enhance the phagocytic ability of mononuclear macrophages and the proliferation of T and B lymphocytes, and mainly treats kidney yin deficiency or liver-kidney yin deficiency. However, most of the herbs in the prescription are yin-nourishing herbs, and yang-deficiency patients are not suitable for use. Therefore, it is an urgent technical problem for those skilled in the art to develop a traditional Chinese medicine compound for enhancing the body's immunity that is highly efficient, safe, has a wide range of applicable populations, has mild medicinal properties, and is suitable for long-term use. Summary of the Invention

[0005] In order to overcome the deficiencies of the prior art, one of the purposes of the present invention is to provide a traditional Chinese medicine preparation for enhancing immunity, which can enhance the immunity of normal mice.

[0006] One of the purposes of the present invention is achieved by adopting the following technical solutions:

[0007] A traditional Chinese medicine preparation for enhancing immunity, comprising the following raw materials in parts by weight: 10-18 parts of red ginseng, 8-15 parts of rhizome of Chinese strawberry tree, 5-10 parts of Chinese wolfberry, 1-5 parts of heart-shaped grass, 2-5 parts of dahurian angelica root, 2-5 parts of polygonatum odoratum, 3-10 parts of rose flower, 1-5 parts of Chinese date, and 1-3 parts of brown sugar.

[0008] Further, it comprises the following raw materials in parts by weight: 12 parts of red ginseng, 11 parts of rhizome of Chinese strawberry tree, 7 parts of Chinese wolfberry, 4 parts of heart-shaped grass, 3 parts of dahurian angelica root, 4 parts of polygonatum odoratum, 9 parts of rose flower, 4 parts of Chinese date, and 2 parts of brown sugar.

[0009] The second object of the present invention is to provide a preparation method of a traditional Chinese medicine preparation for enhancing immunity, and this preparation method is simple and easy to practice.

[0010] The second object of the present invention is achieved by adopting the following technical scheme:

[0011] The preparation method of the above-mentioned traditional Chinese medicine preparation for enhancing immunity comprises the following steps:

[0012] (1) According to the above weight ratio, weigh each raw material, add red ginseng, rhizome of Chinese strawberry tree, Chinese wolfberry, heart-shaped grass, dahurian angelica root, polygonatum odoratum, rose flower, and Chinese date to water for decoction, and obtain the first filtrate and the first filter residue after filtration;

[0013] (2) Add water to the first filter residue in step (1) for decoction, add brown sugar after the decoction is completed and mix evenly, and obtain the second filtrate and the second filter residue after filtration; Combine the first filtrate and the second filtrate and concentrate to an extract, and then add pharmaceutically acceptable excipients to make the corresponding dosage form, thus obtaining.

[0014] Further, the amount of water used in steps (1) and (2) is 5-10 times the total weight of the raw medicinal materials.

[0015] Further, the decoction time in steps (1) and (2) is 1.5-2.5 h.

[0016] Further, the concentration temperature in step (2) is 55-65 °C.

[0017] Further, the relative density of the extract in step (2) is 1.2-1.3.

[0018] Further, the dosage form in step (2) is an oral preparation.

[0019] Further, the oral preparation is one of tablets, granules, and capsules.

[0020] The pharmacological properties analysis of the raw medicinal materials used in the present invention is as follows:

[0021] Red Ginseng:

Properties and Channels Entered

Functions and Indications

[0022] Root of Rhodomyrtus tomentosa:

Properties and Channels Entered

Functions and Indications

[0023] Wolfberry Fruit:

Properties and Channels Entered

Functions and Indications

[0024] Herb of Geum aleppicum: Also known as Geum japonicum Thunb. var. chinense F. Bolle.

Properties and Channels Entered

Functions and Indications

[0025] Angelica Dahurica Root:

Properties and Channels Entered

Functions and Indications

[0026] Polygonatum Odoratum Rhizome:

Properties and Channels Entered

Functions and Indications

[0027] Rose Flower:

Properties and Channels Entered

Functions and Indications

[0028] Chinese Date:

Properties and Channels Entered

Functions and Indications

[0029] Brown Sugar:

Properties and Channels Entered

Functions and Indications

[0030] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0031] In the formula, red ginseng and the root of Rhodomyrtus tomentosa are used as monarch drugs. Red ginseng restores pulse and arrests sweating, replenishes qi and controls bleeding, while the root of Rhodomyrtus tomentosa nourishes blood and tonifies the kidney. Chinese wolfberry and Herba Centranthi Dubii are used as ministerial drugs. Chinese wolfberry nourishes the liver and kidney, and Herba Centranthi Dubii replenishes qi and strengthens the spleen, nourishes blood and nourishes yin. Angelica dahurica, Polygonatum odoratum, rose and Chinese date are used as adjuvant drugs. Angelica dahurica nourishes yin and moistens dryness, Polygonatum odoratum dispels wind and removes dampness, rose promotes qi and relieves depression, and Chinese date invigorates the middle energizer and replenishes qi, nourishes blood and tranquilizes the mind. Brown sugar is used as the guiding drug, which warms the middle energizer and aids the spleen, invigorates the middle energizer and soothes the liver. The combination of various drugs can strengthen the body and enhance immunity by replenishing qi and strengthening the spleen, promoting the production of body fluid and activating blood circulation. Detailed implementation mode

[0032] The following is a further description of the present invention in combination with the detailed implementation mode. It should be noted that on the premise of no conflict, the following described embodiments or technical features can be combined arbitrarily to form new embodiments. The specific conditions not specified in the embodiments are carried out according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are all conventional products obtained through commercial channels without special instructions.

[0033] Embodiment

[0034] Embodiment 1

[0035] This embodiment provides a traditional Chinese medicine preparation for enhancing immunity. The traditional Chinese medicine preparation is composed of the following raw materials in parts by weight: 12 parts of red ginseng, 11 parts of the root of Rhodomyrtus tomentosa, 7 parts of Chinese wolfberry, 4 parts of Herba Centranthi Dubii, 3 parts of Angelica dahurica, 4 parts of Polygonatum odoratum, 9 parts of rose, 4 parts of Chinese date, and 2 parts of brown sugar.

[0036] This embodiment also provides a preparation method of the above traditional Chinese medicine preparation. The detailed preparation steps are as follows:

[0037] (1) According to the above weight ratio, weigh each raw material. According to the water consumption being 8 times the total weight of the raw materials, add red ginseng, the root of Rhodomyrtus tomentosa, Chinese wolfberry, Herba Centranthi Dubii, Angelica dahurica, Polygonatum odoratum, rose and Chinese date to water and decoct for 2 hours. After filtration, obtain the first filtrate and the first filter residue;

[0038] (2) According to the water consumption being 8 times the total weight of the raw materials, add water to the first filter residue in step (1) and decoct for 2 hours. After decoction, add brown sugar and mix evenly. After filtration, obtain the second filtrate and the second filter residue; Combine the first filtrate and the second filtrate and concentrate to an extract with a relative density of 1.2. Based on the mass of the extract, add 2% starch of the extract mass and make it into capsules according to the conventional method.

[0039] Embodiment 2

[0040] This embodiment provides a traditional Chinese medicine preparation for enhancing immunity. The traditional Chinese medicine preparation is composed of the following raw materials in parts by weight: 18 parts of red ginseng, 15 parts of the root of Rhodomyrtus tomentosa, 10 parts of Chinese wolfberry, 5 parts of Herba Centranthi Dubii, 5 parts of Angelica dahurica, 5 parts of Polygonatum odoratum, 10 parts of rose, 5 parts of Chinese date, and 3 parts of brown sugar.

[0041] This embodiment also provides a preparation method of the above traditional Chinese medicine preparation. The detailed preparation steps are as follows:

[0042] (1) Weigh each raw material according to the above weight ratio. Taking the amount of water as 10 times the total weight of the raw medicinal materials, add red ginseng, Rhodomyrtus tomentosa root, wolfberry fruit, Centella acuminata, dahurian angelica root, polygonatum odoratum, rose flower, and red date into water and decoct for 2.5 h. After filtration, obtain the first filtrate and the first residue;

[0043] (2) Taking the amount of water as 10 times the total weight of the raw medicinal materials, add water to the first residue obtained in step (1) and decoct for 2.5 h. After the decoction is completed, add brown sugar and mix evenly. After filtration, obtain the second filtrate and the second residue; Combine the first filtrate and the second filtrate and concentrate to an extract with a relative density of 1.3. Based on the mass of the extract, add 2% starch of the extract mass and make into tablets according to the conventional method.

[0044] Example 3

[0045] This embodiment provides a traditional Chinese medicine preparation for enhancing immunity. The traditional Chinese medicine preparation is composed of the following raw materials in parts by weight: 10 parts of red ginseng, 8 parts of Rhodomyrtus tomentosa root, 5 parts of wolfberry fruit, 1 part of Centella acuminata, 2 parts of dahurian angelica root, 2 parts of polygonatum odoratum, 3 parts of rose flower, 1 part of red date, and 1 part of brown sugar.

[0046] This embodiment also provides a preparation method of the above traditional Chinese medicine preparation. The detailed preparation steps are as follows:

[0047] (1) Weigh each raw material according to the above weight ratio. Taking the amount of water as 5 times the total weight of the raw medicinal materials, add red ginseng, Rhodomyrtus tomentosa root, wolfberry fruit, Centella acuminata, dahurian angelica root, polygonatum odoratum, rose flower, and red date into water and decoct for 1.5 h. After filtration, obtain the first filtrate and the first residue;

[0048] (2) Taking the amount of water as 5 times the total weight of the raw medicinal materials, add water to the first residue obtained in step (1) and decoct for 1.5 h. After the decoction is completed, add brown sugar and mix evenly. After filtration, obtain the second filtrate and the second residue; Combine the first filtrate and the second filtrate and concentrate to an extract with a relative density of 1.2. Based on the mass of the extract, add 1% dextrin and 1% sucrose of the extract mass and make into granules according to the conventional method, thus obtaining the product.

[0049] Comparative Example

[0050] Comparative Example 1

[0051] Comparative Example 1 provides a traditional Chinese medicine preparation. The traditional Chinese medicine preparation is composed of the following raw materials in parts by weight: 12 parts of red ginseng, 7 parts of wolfberry fruit, 4 parts of Centella acuminata, 3 parts of dahurian angelica root, 4 parts of polygonatum odoratum, 9 parts of rose flower, 4 parts of red date, and 2 parts of brown sugar.

[0052] Comparative Example 1 also provides the preparation method of the above traditional Chinese medicine preparation, and the detailed preparation steps and preparation conditions are the same as those in Example 1.

[0053] Comparative Example 2

[0054] Comparative Example 2 provides a traditional Chinese medicine preparation, and the raw material composition of the traditional Chinese medicine preparation includes the following parts by weight: 23 parts of red ginseng, 7 parts of wolfberry fruit, 4 parts of Centella acuminata, 3 parts of angelica dahurica, 4 parts of polygonatum odoratum, 9 parts of rose, 4 parts of Chinese date, and 2 parts of brown sugar.

[0055] Comparative Example 2 also provides the preparation method of the above traditional Chinese medicine preparation, and the detailed preparation steps and preparation conditions are the same as those in Example 1.

[0056] Comparative Example 3

[0057] Comparative Example 3 provides a traditional Chinese medicine preparation, and the raw material composition of the traditional Chinese medicine preparation includes the following parts by weight: 12 parts of red ginseng, 11 parts of Rhodomyrtus tomentosa root, 7 parts of wolfberry fruit, 3 parts of angelica dahurica, 4 parts of polygonatum odoratum, 9 parts of rose, 4 parts of Chinese date, and 2 parts of brown sugar.

[0058] Comparative Example 3 also provides the preparation method of the above traditional Chinese medicine preparation, and the detailed preparation steps and preparation conditions are the same as those in Example 1.

[0059] Comparative Example 4

[0060] Comparative Example 4 provides a traditional Chinese medicine preparation, and the raw material composition of the traditional Chinese medicine preparation includes the following parts by weight: 12 parts of red ginseng, 11 parts of Rhodomyrtus tomentosa root, 11 parts of wolfberry fruit, 3 parts of angelica dahurica, 4 parts of polygonatum odoratum, 9 parts of rose, 4 parts of Chinese date, and 2 parts of brown sugar.

[0061] Comparative Example 4 also provides the preparation method of the above traditional Chinese medicine preparation, and the detailed preparation steps and preparation conditions are the same as those in Example 1.

[0062] The pharmacodynamic effects of the traditional Chinese medicine preparations prepared in Examples 1-3 and Comparative Examples 1-4 are described below, and the detailed process is as follows:

[0063] (1) Experimental animals

[0064] A total of 80 SPF-grade Balb / c nude mice, with a male-female ratio of 1:1 and a body weight of 18-22 g.

[0065] (2) Experimental grouping

[0066] All the experimental animals were randomly divided into low, medium, and high-dose groups of Example 1, high-dose group of Comparative Example 1, high-dose group of Comparative Example 2, high-dose group of Comparative Example 3, high-dose group of Comparative Example 4, and normal control group, with 10 animals in each group.

[0067] (3) Administration method

[0068] Example 1, low-dose group: The traditional Chinese medicine preparation of Example 1 was administered by gavage at a dose of 5 g / kg (raw drug), once a day for 30 consecutive days;

[0069] Example 1, medium-dose group: The traditional Chinese medicine preparation of Example 1 was administered by gavage at a dose of 10 g / kg (raw drug), once a day for 30 consecutive days;

[0070] Example 1, high-dose group: The traditional Chinese medicine preparation of Example 1 was administered by gavage at a dose of 20 g / kg (raw drug), once a day for 30 consecutive days;

[0071] Control group 1, high-dose group: The traditional Chinese medicine preparation of Control group 1 was administered by gavage at a dose of 20 g / kg (raw drug), once a day for 30 consecutive days;

[0072] Control group 2, high-dose group: The traditional Chinese medicine preparation of Control group 2 was administered by gavage at a dose of 20 g / kg (raw drug), once a day for 30 consecutive days;

[0073] Control group 3, high-dose group: The traditional Chinese medicine preparation of Control group 3 was administered by gavage at a dose of 20 g / kg (raw drug), once a day for 30 consecutive days;

[0074] Control group 4, high-dose group: The traditional Chinese medicine preparation of Control group 4 was administered by gavage at a dose of 20 g / kg (raw drug), once a day for 30 consecutive days;

[0075] Normal control group: Administered an equal volume of normal saline by gavage, once a day for 30 consecutive days.

[0076] (4) Detection indexes

[0077] a. Organ index

[0078] The body weights of the mice in each group were weighed and recorded every day. After dissection, the spleens and thymuses of the mice in each group after sacrifice were taken out, rinsed with normal saline and then dried with filter paper, weighed and the organ index was calculated. The calculation formula is as follows:

[0079] Organ index = organ mass (mg) / body weight (g). The results are shown in Table 1.

[0080] b. Phagocytic function of phagocytes

[0081] The phagocytic function of phagocytes was detected by the carbon particle clearance method. The specific detection method is as follows:

[0082] 30 minutes after the last administration, 0.05 mL / 10 g of India ink diluted 3 times was injected into the tail vein of the mice in each group. Blood samples of 20 μL were taken from the posterior orbital sinus at 30 s (t 1 ) and 360 s (t 2 ) respectively, and added to 0.1% Na2 CO 3 Shake well in 2 mL of the solution and measure the optical density at a wavelength of 680 nm, OD 1 represents the optical density value at 30 s, OD 2 represents the optical density value at 360 s. Calculate the clearance index K according to the formula. After converting the K value by body weight and liver and spleen weights, the phagocytosis coefficient is obtained. The results are shown in Table 2.

[0083] Clearance index K = (lgOD 1 -lgOD 2 ) / (t 2 -t 1 ),

[0084] c. Lymphocyte transformation ability

[0085] Detect using the mouse spleen lymphocyte transformation experiment induced by ConA (MTT method). The specific detection method is as follows:

[0086] Grind the spleens of the mice in each group and make cell suspensions, and adjust the cell concentration to 3×10 5 cells / mL. Add each group of cell suspensions to a 24-well plate, 2 wells per group, 1 mL per well, and add 75 μL of ConA solution to one well (denoted as well A), and add an equal volume of RPMI 1640 culture medium without FBS to the other well (denoted as well B). Set 3 replicate wells for each group. Incubate the 24-well plate in a cell culture incubator at 37 °C and 5% CO 2 for 72 h. And 4 h before the end of the culture, gently aspirate 0.7 mL of the supernatant from each well, then add 0.7 mL of RPMI 1640 culture medium without FBS, and at the same time add 50 μL / well of MTT (5 mg / mL), and continue to culture for 4 h. After the culture is completed, add 1 mL of acidic isopropanol to each well, pipette and mix well to dissolve the purple crystals, and then measure the optical density of each well at 570 nm. At the same time, set control wells containing only each group of cell suspensions and MTT solution. The calculation formula for the transformation ability of lymphocytes is as follows:

[0087] Lymphocyte transformation ability (%) = (Well A OD - Control well OD ) / (Well B OD - Control well OD ), and the results are shown in Table 2.

[0088] Table 1

[0089]

[0090]

[0091] Table 2

[0092] Grouping Dose Phagocytosis coefficient Lymphocyte transformation ability (%) Normal control group / 5.38 18.22 Low-dose group of Example 1 5 g / kg 5.74 24.01 Medium-dose group of Example 1 10 g / kg 6.19 26.30 High-dose group of Example 1 20 g / kg 6.43 28.02 High-dose group of Comparative Example 1 20 g / kg 5.45 19.43 High-dose group of Comparative Example 2 20 g / kg 5.57 20.65 High-dose group of Comparative Example 3 20 g / kg 5.60 22.38 High-dose group of Comparative Example 4 20 g / kg 5.63 23.54

[0093] As can be seen from Table 1, the traditional Chinese medicine preparation obtained in the present invention can significantly increase the organ coefficients of the immune organs of normal mice, that is, the traditional Chinese medicine preparation obtained in the present invention has an enhancing effect on the immune organs of normal mice.

[0094] As can be seen from Table 2, the traditional Chinese medicine preparation obtained in the present invention can significantly enhance the transformation ability of mouse splenic lymphocytes induced by ConA and the phagocytosis coefficient of normal mice, that is, the traditional Chinese medicine preparation obtained in the present invention has an enhancing effect on the lymphocyte transformation ability of normal mice and the phagocytic function of macrophages. In summary, the traditional Chinese medicine preparation obtained in the present invention can improve the immunity of normal mice.

[0095] Compared with Example 1, in Comparative Example 1, the root of Rhodomyrtus tomentosa was omitted; in Comparative Example 2, the root of Rhodomyrtus tomentosa was omitted and the dosage of red ginseng was increased; in Comparative Example 3, the herb of Hedyotis dissitiflora was omitted; in Comparative Example 4, the herb of Hedyotis dissitiflora was omitted and the dosage of wolfberry was increased. The enhancing effect of the obtained traditional Chinese medicine preparation on the immunity of normal mice was reduced. The above results show that the root of Rhodomyrtus tomentosa and red ginseng are used together as the monarch drugs, and wolfberry and the herb of Hedyotis dissitiflora are used together as the minister drugs, which can enhance the immunity of normal mice.

[0096] The above embodiments are only the preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantive changes and substitutions made by those skilled in the art based on the present invention belong to the scope of protection required by the present invention.

Claims

1. A Chinese medicine preparation for improving immunity, characterized in that: The invention comprises the following raw materials in parts by weight: 10-18 parts of red ginseng, 8-15 parts of rhizoma strychnifoliae, 5-10 parts of wolfberry, 1-5 parts of red heart grass, 2-5 parts of angelica dahurica, 2-5 parts of polygonatum odoratum, 3-10 parts of rose, 1-5 parts of red dates and 1-3 parts of brown sugar.

2. The Chinese medicine preparation for improving immunity according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 12 parts of red ginseng, 11 parts of rhizoma strychnifoliae, 7 parts of wolfberry, 4 parts of red heart grass, 3 parts of angelica dahurica, 4 parts of polygonatum odoratum, 9 parts of rose, 4 parts of red dates and 2 parts of brown sugar.

3. The method for preparing the immunity-enhancing Chinese medicinal preparation according to claim 1 or 2, characterized in that: The following steps are involved: (1) weighing the raw materials according to the above weight ratio, adding red ginseng, rhizoma strychnifoliae, wolfberry, herba scutellariae, angelica dahurica, polygonatum odoratum, rose, and red dates into water for decoction, and filtering to obtain a first filtrate and a first filter residue; (2) adding water to the first filter residue of step (1) for decoction, adding brown sugar after decoction and mixing evenly, filtering to obtain a second filtrate and a second filter residue; combining the first filtrate and the second filtrate and concentrating them into an extract, and then adding pharmaceutically acceptable excipients to prepare a corresponding dosage form.

4. The method for preparing the immunity-enhancing Chinese medicinal preparation according to claim 3, characterized in that: The amount of water used in steps (1) and (2) is 5 to 10 times the total weight of the raw material.

5. The method for preparing the immunity-enhancing Chinese medicinal preparation according to claim 3, characterized in that: The decoction time in steps (1) and (2) is 1.5 to 2.5 hours.

6. The method for preparing the immunity-enhancing Chinese medicinal preparation according to claim 3, characterized in that: The concentration temperature in step (2) is 55-65°C.

7. The method for preparing the immunity-enhancing Chinese medicinal preparation according to claim 3, characterized in that: The relative density of the extract in step (2) is 1.2 to 1.

3.

8. The method for preparing the immunity-enhancing Chinese medicinal preparation according to claim 3, characterized in that: The dosage form described in step (2) is an oral preparation.

9. The method for preparing the immunity-enhancing Chinese medicinal preparation according to claim 8, characterized in that: The oral preparation is one of tablets, granules and capsules.

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