Biocompatible self-clamping optical fiber tweezers and preparation method thereof

Abstract

The invention relates to the technical field of micro-nano device manufacturing, in particular to bio-compatible self-clamping optical fiber tweezers and a preparation method thereof. The invention designs a pair of bio-compatible self-clamping optical fiber tweezers. The clamping part of the tweezers is in a self-clamping closed state in the absence of external force; therefore, when an object needs to be clamped, photothermal effect stimulation is generated through the laser irradiation effect to enable the driving part to contract so as to enable the clamping part to be opened, then the laser can be closed to enable the photothermal effect stimulation to disappear so as to enable the clamping part to be reset to be in a closed state to achieve clamping, and therefore long-time driving of the laser is not needed. Therefore, the clamped object is protected from being influenced by the high-energy-density laser to the greatest extent, the problems that the object is subjected to thermal damage and the biological activity is reduced are solved, and the biological compatibility of the optical fiber tweezers is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of micro-nano device manufacturing, and particularly relates to: 1. A biocompatible self-clamping optical fiber tweezer; 2. A preparation method of the biocompatible self-clamping optical fiber tweezer. Background Art

[0002] The manipulation of tiny objects (such as single cells, bacteria, micro-nano particles) in space is of great importance in fields such as biomedicine, materials science, and chemical engineering. Operators hope to precisely control the position and movement of these tiny objects in order to study their physical properties, biological activities, or interactions.

[0003] As a micro-mechanical device for manipulating tiny objects, a microgripper can grip and move tiny objects such as micron- and even nano-scale particles and cells, and is widely used in fields such as bioengineering, micro-nano operation, and micro-assembly.

[0004] Traditional microgrippers utilize the inverse piezoelectric effect of piezoelectric materials, that is, the material deforms under the action of an electric field, and the opening or closing of the jaws is controlled by a piezoelectric actuator. However, due to the usually high driving voltage, the material properties and lifespan are restricted by the voltage intensity, and at the same time, the piezoelectric material itself has a high cost and complex manufacturing processes.

[0005] Subsequently, light-driven microgrippers emerged. They are micro-devices that use photosensitive materials (also known as photo-responsive materials) to achieve the gripping action, and the gripping and releasing of tiny objects are controlled by the irradiation of an external light source (usually a laser). The light-driven microgripper does not require wire control, reducing interference caused by physical contact. At the same time, the laser can precisely focus to drive the microgripper so that it can be positioned and operated at the micron or even nano scale. For example, the Chinese invention patent with the patent number CN202211164413.4 discloses an optical fiber end face light-driven microgripper and its preparation method. When the light is not turned on, the microgripper opens, and when the optical fiber is irradiated with light, the microgripper closes, thus achieving gripping. However, through experiments, it is found that if the gripped objects are biological structures such as cells and bacteria, this light-driven microgripper will cause damage to the gripped objects and reduce their biological activity. Summary of the Invention

[0006] In order to solve the problem that the existing light-driven microgripper will cause damage to the gripped objects and reduce their biological activity during use, the present invention provides a biocompatible self-clamping optical fiber tweezer and its preparation method.

[0007] The present invention is realized by adopting the following technical solutions:

[0008] In a first aspect, the present invention discloses a biocompatible self-clamping optical fiber tweezer, comprising: an optical fiber and a self-clamping mechanism. The self-clamping mechanism is disposed on the end face of the optical fiber. The optical fiber is used to apply controllable laser irradiation to the self-clamping mechanism to generate or lose the stimulation of photothermal effect.

[0009] The self-clamping mechanism includes: a driving part and a clamping part; the driving part is in contact with or connected to the clamping part.

[0010] The driving part is made of a hydrogel deposited with metal particles; the clamping part is made of a photoresist.

[0011] When no external force acts on the clamping part, it is in a self-clamping closed state.

[0012] The driving part drives the clamping part to open when it undergoes volume contraction under the stimulation of photothermal effect, and drives the clamping part to reset to the closed state when the photothermal effect stimulation disappears to achieve clamping.

[0013] The realization of this biocompatible self-clamping optical fiber tweezer is based on the method or process of the embodiments of the present disclosure.

[0014] In a second aspect, the present invention discloses a preparation method of a biocompatible self-clamping optical fiber tweezer, which is used to prepare the biocompatible self-clamping optical fiber tweezer disclosed in the first aspect.

[0015] A preparation method of a biocompatible self-clamping optical fiber tweezer includes the following steps:

[0016] Step 1, cleaning the end face of the optical fiber;

[0017] Step 2, based on the three-dimensional model of the clamping part, using femtosecond laser to process the clamping part on the end face of the optical fiber immersed in the photoresist;

[0018] Step 3, based on the three-dimensional model of the driving part, using femtosecond laser to process the driving part on the end face of the optical fiber immersed in the hydrogel solution;

[0019] Step 4, performing metal ion deposition treatment on the processed driving part.

[0020] The realization of this preparation method of a biocompatible self-clamping optical fiber tweezer is based on the method or process of the embodiments of the present disclosure.

[0021] The present invention has the following beneficial effects:

[0022] 1. The present invention designs a biocompatible self-clamping optical fiber tweezer, whose clamping part is in a self-clamping closed state without external force. Then, when an object needs to be clamped, first, a photothermal effect is generated through laser irradiation to stimulate the driving part to contract and open the clamping part. After that, the laser can be turned off to make the photothermal effect stimulation disappear, and the clamping part can be reset to the closed state to achieve clamping. In this way, long-term laser driving is not required, thus protecting the clamped object from the influence of high-energy-density laser to the greatest extent, improving the problems of thermal damage and reduced biological activity of the object, and enhancing the biocompatibility of the optical fiber tweezer.

[0023] 2. The present invention also proposes a preparation method for the designed biocompatible self-clamping optical fiber tweezer, which is based on femtosecond laser processing to ensure the precision and effect of the finished product. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0025] Figure 1 Structural diagram of the biocompatible self-clamping optical fiber tweezer provided in Embodiment 1 of the present invention;

[0026] Figure 2 For Figure 1 Structural diagram of the self-clamping mechanism in

[0027] Figure 3 For Figure 1 State diagrams of the biocompatible self-clamping optical fiber tweezer in when it is opened and closed;

[0028] Figure 4 For Figure 2 Structural diagram of the driving part in

[0029] Figure 5 For Figure 2 Structural diagram of the clamping part in

[0030] Figure 6 For Figure 1 Multiple state diagrams of the biocompatible self-clamping optical fiber tweezer when working on biological cells;

[0031] Figure 7 Flowchart of the preparation method of the biocompatible self-clamping optical fiber tweezer provided in Embodiment 2 of the present invention.

[0032] In the drawings, the list of components represented by each reference numeral is as follows:

[0033] 1. Clamping part, 2. Driving part, 3. Optical fiber;

[0034] 101. Connecting seat, 102. Support column, 103. Gripper seat, 104. Gripper column;

[0035] 1041. Outer end, 1042. Inner end, 1043. Triangular groove;

[0036] 201. Deformation strip, 202. Through hole. Specific implementation mode

[0037] In order to make the objectives, technical solutions and advantages of the present invention clearer and more understandable, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0038] Embodiment 1

[0039] First of all, it should be noted that, as described in the background art, using the existing optical drive microgripper will cause damage to the clamped object and reduce its biological activity. After analysis, the damage suffered by the clamped object is thermal damage - because the laser, as a coherent light source with a high energy density, will irradiate the clamped object for a long time when driving the microgripper, thus causing thermal damage. Moreover, the laser has a high energy density, and after irradiating the clamped object for a long time, it will reduce its biological activity.

[0040] After understanding the above reasons, the present invention newly designs a biocompatible self-clamping optical fiber tweezer. Refer to Figure 1 , which shows the structural diagram of the biocompatible self-clamping optical fiber tweezer, and it includes: an optical fiber 3 and a self-clamping mechanism. The self-clamping mechanism is arranged on the end face of the optical fiber 3. The optical fiber 3 is used to apply controllable laser irradiation to the self-clamping mechanism to generate or lose the photothermal effect stimulation.

[0041] As Figure 1 shown, the optical fiber 3 includes: an inner core and an outer cladding. The cladding protects the core, and the core can conduct laser: when the laser is passed into the core, the end face of the optical fiber will generate laser irradiation on the self-clamping mechanism; once the laser is turned off, the end face of the optical fiber will no longer perform laser irradiation on the self-clamping mechanism. Of course, considering the directivity of the laser, generally the self-clamping mechanism is processed at the position corresponding to the core on the end face to ensure the effect of laser irradiation.

[0042] As Figure 2As shown in the figure, the self-clamping mechanism includes: a driving part 2 and a clamping part 1. The driving part 2 is in contact with or connected to the clamping part 1. It should be noted that the relationship between the driving part 2 and the clamping part 1 should meet the following condition: if the driving part 2 deforms, the clamping part 1 will also be driven and undergo corresponding changes. Of course, to ensure the reliability of their functions, it is recommended to design it such that the driving part 2 is sleeved on the clamping part 1.

[0043] It should be noted that the driving part 2 is made of a hydrogel deposited with metal particles (such as silver ions, gold ions, copper ions, etc.); the clamping part 1 is made of a photoresist (which can be a commercial photoresist such as SU-8, IP-S, or other commercial types or self-prepared photoresists). The two have a certain degree of adhesiveness, so even in contact, the above requirements can be met based on the adhesive effect. Both also have a certain degree of light transmittance, allowing the laser to pass through: for the driving part 2, after the laser is introduced, the metal particles in the hydrogel absorb the light energy of the laser and convert it into heat energy, that is, a photothermal effect stimulation is formed; after the laser is turned off, the metal particles in the hydrogel no longer generate heat, and the photothermal effect stimulation disappears.

[0044] For the self-clamping mechanism, it meets the following conditions:

[0045] First, when there is no external force acting on the clamping part 1, it is in a self-clamping closed state.

[0046] The "no external force acting" here means that when the driving part 2 does not undergo a volume change, at this time, the driving part 2 does not exert an external force on the clamping part 1.

[0047] Second, when the driving part 2 is stimulated by the photothermal effect and undergoes volume contraction, it drives the clamping part 1 to open, and when the photothermal effect stimulation disappears, it undergoes volume recovery and drives the clamping part 1 to reset to the closed state to achieve clamping.

[0048] That is to say:

[0049] ①. When the laser is introduced, due to the temperature increase brought by the metal particles, the water molecules in the hydrogel escape from the hydrogel network structure under the condition of temperature increase, resulting in a reduction in the volume of the driving part 2. When the volume of the driving part 2 contracts, it pulls the clamping part 1 outward in all directions, thereby causing the clamping part 1 to open.

[0050] ②. When the laser is turned off, since the metal particles no longer generate heat, the temperature of the driving part 2 recovers, and the water molecules re-enter the hydrogel, resulting in a recovery of the volume of the driving part 2. When the volume of the driving part 2 recovers, it pushes the clamping part 1 inward from all directions, thereby causing the clamping part 1 to reset to the closed state.

[0051] The schematic diagrams of the above processes ① and ② are as shown in Figure 3As shown. Then, when it is necessary to clamp an object, first, the photothermal effect is generated through laser irradiation to stimulate the driving part 2 to contract, causing the clamping part 1 to open. After that, the laser can be turned off to make the photothermal effect stimulation disappear, enabling the clamping part 1 to reset to the closed state to achieve clamping. In this way, long-term laser driving is not required.

[0052] Refer to Figure 4 , the clamping part 1 can be designed to include: a connecting seat 101, a gripper mechanism, and a support column 102. The connecting seat 101 is connected to the end face of the optical fiber 3. Generally, the connecting seat 101 is designed in a regular shape - such as circular or square - to have sufficient contact area with the optical fiber end face to achieve firm attachment to the optical fiber end face.

[0053] As Figure 4 shown, the gripper mechanism includes: a gripper seat 103 and N gripper columns 104. The gripper seat 103 includes N mounting plates; the N mounting plates are evenly distributed in a petal shape, with their inner ends connected together and serving as the center of the gripper seat 103; the N gripper columns 104 are correspondingly arranged on the side of the mounting plate facing away from the connecting seat 101. The gripper seat 103 adopts the above petal design instead of a complete circle or square similar to the connecting seat 101: This can not only reduce the weight, but also there are intervals between the mounting plates, making the deformation more free when the driving part 2 acts later.

[0054] One end of the support column 102 is connected to the connecting seat 101, and the other end is connected to the center of the gripper seat 103. Among them, the end of the support column 102 connected to the connecting seat 101 can also be located at the center of the connecting seat 101 to ensure uniform force.

[0055] It should be noted that N is at least 3, so as to maintain clamping the object from at least 3 directions. As Figure 4 shown, it shows the case where N takes 3. Of course, considering the actual design, the value of N should not be too large, and generally 3 or 4 is sufficient.

[0056] As Figure 5 shown, the driving part 2 includes: N deformation strips 201. The N deformation strips 201 are evenly distributed in a petal shape, with their inner ends connected together and provided with through holes 202; the N deformation strips 201 are sleeved on the support column 102 through the through holes 202, with one end in contact with or connected to the connecting seat 101 and the other end in contact with or connected to the N mounting plates correspondingly.

[0057] In this way, the driving part 2 is sleeved on the support column 102, which can effectively avoid the situation of the driving part 2 detaching from the clamping part 1. Moreover, similar to the gripper seat 103, the driving part 2 adopts a petal design instead of a complete circle or square similar to the connecting seat 101: This can not only reduce the weight, but also there are intervals between the deformation strips 201, making the deformation more free when stimulated by the photothermal effect.

[0058] Moreover, a deformation strip 201 is correspondingly arranged with a mounting plate and can be regarded as forming a set of driving and deforming components; there is no interference between different sets of driving and deforming components - its acting direction is: pulling outwards from the inside to the surroundings or squeezing inwards from the surroundings to the inside. That is to say: when the clamping part 1 is opened, the ends of the N gripper columns 104 away from the mounting plate move away from each other; when the clamping part 1 is closed, the ends of the N gripper columns 104 away from the mounting plate approach each other to generate a clamping effect.

[0059] In addition, considering the usage scenario of this fiber optic tweezer, the gripper columns 104 can be designed to be arc-shaped, so that the N gripper columns 104 enclose the internal space of an ellipsoid, in order to more stably clamp an object in the closed state.

[0060] For the gripper column 104, the end away from the gripper plate can be designed as an outer end head 1041 in the shape of a spherical crown. In this way, in the closed state, the area A enclosed by the outer end head 1041 can be used to perform the tweezer-taking action on the clamped object, so as to avoid physical damage to the clamped object as much as possible. In addition, a convex inner end head 1042 is machined near the inner circle of the gripper column 104 close to the mounting plate. In this way, when clamping a long object, the inner end head 1042 can cooperate with the outer end head 1041 to clamp both ends of the object to prevent the object from falling off. In addition, a triangular groove 1043 can be machined between the inner end head 1042 and the end of the gripper column 104 connected to the mounting plate. In this way, not only does the inner end head 1042 protrude, but it can also reduce the weight of the gripper structure, and it can also provide a certain amount of deformation redundancy between the gripper column 104 and the mounting plate to make the gripper mechanism more gentle when clamping.

[0061] In addition, referring to Figure 6 , which shows the process of this fiber optic tweezer from opening, closing to reopening: Figure 6 The area (a) in Figure 6 represents that this fiber optic tweezer moves near a biological cell; Figure 6 The areas (b) to (c) in Figure 6 represent that this fiber optic tweezer opens and approaches the biological cell; Figure 6 The area (d) in

[0062] Example 2

[0063] This Example 2 provides a preparation method for a biocompatible self-clamping fiber optic tweezer for preparing the biocompatible self-clamping fiber optic tweezer of Example 1.

[0064] Generally speaking, referring to Figure 7, the preparation method of the biocompatible self-clamping optical fiber tweezers comprises the following steps:

[0065] Step 1, clean the end face of the optical fiber 3;

[0066] Specifically, the optical fiber 3 can be a multimode optical fiber 3 with a specification of 50 / 125 μm.

[0067] First, use a wire stripper to strip the coating layer with a length of 1.5 cm at one end of the optical fiber 3, then clean the residue with an ethanol solution, and then cut out a flat end face with an optical fiber 3 cutter; then immerse the flat end face in a toluene solution of 1 mM 3-(trimethoxysilyl)propyl methacrylate, rinse it with acetone and deionized water after one hour, and air dry it for later use.

[0068] Of course, the tools, reagents, processing parameters, etc. used in the above operations can be adjusted according to the actual situation, but the cleaning effect of the optical fiber end face should be ensured.

[0069] Step 2, based on the three-dimensional model of the clamping part 1, use femtosecond laser to process the clamping part 1 on the end face of the optical fiber immersed in the photoresist.

[0070] Referring to the description of Embodiment 1, different specifications of photoresist can be used for the clamping part 1.

[0071] Then, if SU-8 is used, there is: based on the clamping part 1 of Embodiment 1, use three-dimensional software (such as Proe, Solidworks, etc.) to construct a three-dimensional model and convert it into three-dimensional point coordinate data; drop SU-8 on the glass slide of the three-dimensional processing platform, immerse the end face of the optical fiber processed in Step 1 in the photoresist, use a femtosecond laser (wavelength 517 nm, laser power 33 mw) to process the end face of the optical fiber, control the three-dimensional processing platform to perform X-Y-Z combined movement, and print the clamping part 1 on the end face of the optical fiber; then immerse the end face of the optical fiber together with the printed clamping part 1 in propylene glycol monomethyl ether acetate (PGMEA) for 15 minutes to remove the unpolymerized SU-8, and finally immerse it in isopropyl alcohol (IPA) for 5 minutes to remove the residual propylene glycol monomethyl ether acetate (PGMEA).

[0072] If IP-S is used, the following steps are taken: Based on the clamping part 1 in Embodiment 1, a 3D model is constructed using 3D software (such as Proe, Solidworks, etc.) and converted into 3D point coordinate data; IP-S is dropped onto the glass slide of the 3D processing platform, and the end face of the optical fiber after being processed in Step 1 is immersed in the photoresist. A femtosecond laser (wavelength 517 nm, laser power 30 mw) is used to process the end face of the optical fiber, and the 3D processing platform is controlled to perform X - Y - Z combined movement to print the clamping part 1 on the end face of the optical fiber; then the end face of the optical fiber together with the printed clamping part 1 is immersed in propylene glycol methyl ether acetate (PGMEA) for 20 min to remove the unpolymerized IP-S, and finally soaked in isopropyl alcohol (IPA) for 2 min to remove the residual propylene glycol methyl ether acetate (PGMEA).

[0073] Of course, if photoresists of other specifications are used, the above parameters should be adjusted accordingly, but the processing effect of the clamping part 1 needs to be ensured.

[0074] Step 3: Based on the 3D model of the driving part 2, a femtosecond laser is used to process the driving part 2 on the end face of the optical fiber immersed in the hydrogel solution.

[0075] Among them, the hydrogel solution can be obtained by the following preparation method:

[0076] 400 mg of the thermoresponsive monomer N-isopropylacrylamide (NIPAM), 30 mg of the crosslinking agent methylene-bisacrylamide (MBA), 30 mg of the photoinitiator diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO), and 50 mg of polyvinylpyrrolidone (PVP, K30) are dissolved in 450 μL of ethylene glycol and ultrasonicated for 5 minutes to mix evenly, thereby preparing the hydrogel solution.

[0077] It should be noted that since the printing mechanical strength of N-isopropylacrylamide is poor, 50 mg of polyvinylpyrrolidone (PVP, K30) is added to improve the mechanical ability of the hydrogel by constructing hydrogen bonds with N-isopropylacrylamide; moreover, the addition of polyvinylpyrrolidone can significantly increase the viscosity of the hydrogel precursor and prevent the reduction of the processing quality caused by the flow of the hydrogel during the processing.

[0078] Then, specifically,

[0079] Based on the driving part 2 in Embodiment 1, a three-dimensional model is constructed using three-dimensional software (such as Proe, Solidworks, etc.) and converted into three-dimensional point coordinate data; the fiber end face after being processed in Step 2 is immersed in a hydrogel solution, and a femtosecond laser (wavelength 517 nm, laser power 33 mw) is used to process the fiber end face. The three-dimensional processing platform is controlled to perform X - Y - Z combined movement, and the driving part 2 is printed at the position of the clamping part 1 on the fiber end face so that the driving part 2 and the clamping part 1 are in the setting relationship of Embodiment 1; then the fiber end face together with the printed driving part 2 and clamping part 1 are immersed in a developing solution (ethanol) for 15 min to remove the uncured hydrogel.

[0080] Step Four, perform metal ion deposition treatment on the processed driving part 2.

[0081] Generally, the processed driving part 2 is immersed in a metal salt solution for metal ion deposition treatment.

[0082] Referring to the description in Embodiment 1, various metal ions such as silver ions, gold ions, and copper ions can be used. In this Embodiment 2, silver ions are used as the metal ions, and then silver ammonia solution is recommended as the metal salt solution.

[0083] Among them, the silver ammonia solution can be prepared by the following preparation method:

[0084] Add 14.1 mg of silver nitrate aqueous solution and 13.4 mg of sodium citrate to 1 ml of deionized water, stir to obtain a mixture; then drop 100 μL of ammonia water (25 - 28% NH3 in H2O) into the mixture and stir until the solution is clear, thus obtaining the silver ammonia solution.

[0085] Then, specifically,

[0086] First, preheat the silver ammonia solution in a container to 35 degrees Celsius to promote the photoreduction reaction; among them, the container is equipped with magnetic stirring to prevent local concentration differences of Ag+;

[0087] Then immerse the fiber end face after being processed in Step Three into the silver ammonia solution for 15 min to allow it to fully penetrate and adsorb in the pores of the hydrogel; couple a laser with a wavelength of 405 nm into the other end of the optical fiber 3, the laser power is 2.0 - 3.0 mW, and turn off the laser after 1 s; in this way, under the irradiation of the emitted laser, Ag+ absorbs light energy and is reduced to silver nanoparticles under the action of sodium citrate and is evenly distributed in the driving part 2.

[0088] Thus, a biocompatible self-clamping optical fiber tweezer is prepared.

[0089] Of course, if other metal ions are used, the above reagent selection and operations need to be adjusted accordingly, but the effect of the deposition treatment needs to be ensured.

[0090] It should be noted that:

[0091] 1. By changing the type of photoresist, performance trade-offs can be made among manufacturing precision, mechanical strength, and thermal stability to meet different application requirements.

[0092] 2. By adjusting the laser processing parameters, the cross-linking density of the hydrogel can be changed, thereby regulating the clamping force of the optical fiber tweezers; the type and density of deposited metal ions in the light-driven hydrogel can be changed, thereby adjusting the sensitivity of the optical fiber tweezers.

[0093] The above-described embodiments merely represent several implementation manners of the present invention. The description is relatively specific and detailed, but it should not be construed as a limitation on the scope of the invention patent. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several modifications and improvements can still be made, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the present invention patent shall be subject to the appended claims.

Claims

1. A biocompatible self-gripping optical fiber tweezers, comprising: An optical fiber and a self-clamping mechanism, wherein the self-clamping mechanism is arranged on an end face of the optical fiber; The optical fiber is used to apply controllable laser irradiation to the self-clamping mechanism to generate or lose photothermal effect stimulation; the self-clamping mechanism comprises: a driving part and a clamping part; the driving part is in contact with or connected to the clamping part; the characteristics are: The driving part is made of hydrogel with metal particles deposited on it; the clamping part is made of photoresist; When there is no external force acting on the clamping part, it is in a self-clamping closed state; The driving part contracts in volume when stimulated by the photothermal effect, driving the clamping part to open; after the photothermal effect stimulation disappears, the driving part recovers in volume, driving the clamping part to return to a closed state to achieve clamping.

2. The biocompatible self-gripping optical fiber forceps according to claim 1, characterized in that: The driving part is sleeved on the clamping part.

3. The biocompatible self-gripping optical fiber forceps according to claim 2, characterized in that: The clamping part includes: Connecting seat, gripper mechanism, support column; The connection seat is connected to the end face of the optical fiber; The gripper mechanism comprises: a gripper seat and N gripper columns; the gripper seat comprises N mounting plates; the N mounting plates are evenly distributed in a petal shape, the inner ends of which are connected together and serve as the center of the gripper seat; the N gripper columns are arranged one by one on the side of the mounting plate facing away from the connecting seat; N≥3; One end of the support column is connected to the connecting seat, and the other end is connected to the center of the gripper seat.

4. The biocompatible self-gripping optical fiber forceps according to claim 3, characterized in that: The drive unit includes: N deformation bars; N deformable strips are evenly distributed in a petal shape, the inner ends of which are connected together and provided with through holes; N deformation bars are sleeved on the support column through the through holes, one end of the deformation bars is in contact with or connected to the connection seat, and the other end of the deformation bars is in contact with or connected to the N installation plates in a one-to-one correspondence.

5. The biocompatible self-gripping optical fiber forceps according to claim 4, characterized in that: When the clamping portion is opened, the ends of the N gripper columns away from the mounting plate are away from each other; When the clamping portion is closed, the ends of the N gripper columns away from the mounting plate approach each other to produce a clamping effect.

6. The biocompatible self-gripping optical fiber forceps according to claim 5, characterized in that: N gripper columns enclose the inner space of the ellipsoid.

7. The biocompatible self-gripping optical fiber tweezers according to claim 5, characterized in that: One end of the gripping column away from the gripping plate is an outer end head in a spherical crown shape.

8. The biocompatible self-gripping optical fiber forceps according to claim 5, characterized in that: The inner circle of the gripping column is provided with a raised inner end near the mounting plate.

9. The biocompatible self-gripping optical fiber forceps according to claim 8, characterized in that: A triangular groove is also arranged between the inner end and one end of the gripping column connected to the mounting plate.

10. A method for preparing a biocompatible self-gripping optical fiber tweezers, characterized in that: It is used to prepare the biocompatible self-gripping optical fiber tweezers as described in any one of claims 1 to 9; It includes the following steps: Step 1: Clean the end face of the optical fiber; Step 2: Based on the three-dimensional model of the clamping part, a femtosecond laser is used to process the clamping part on the end face of the optical fiber immersed in the photoresist; Step 3, based on the three-dimensional model of the driving part, a femtosecond laser is used to process the driving part on the end face of the optical fiber immersed in the hydrogel solution; Step 4: Perform metal ion deposition treatment on the processed driving part.

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