Application of American cockroach powder in medicine for treating thyroid sarcoidosis

Abstract

The invention belongs to the field of traditional Chinese pharmacology, and provides application of American cockroach powder in a medicine for treating thyroid sarcoidosis. The invention further provides a traditional Chinese medicine composition for treating pulmonary nodule. The traditional Chinese medicine composition is prepared from, by weight, 6-9 parts of American cockroach, 3-10 parts of radix bupleuri, 6-10 parts of rhizoma cyperi, 3-9 parts of rhizoma pinelliae preparata, 9-15 parts of selfheal and 5-10 parts of thunberg fritillary bulb. The invention provides a new application of the American cockroach powder in medicine, and clinically finds that the American cockroach powder has a good effect of treating thyroid nodules independently or together with other traditional Chinese medicines, so that a new direction is provided for the development of the traditional Chinese medicine American cockroach.

Description

Technical Field

[0001] The present invention belongs to the field of traditional Chinese medicine, and relates to the application of Periplaneta americana in the treatment of thyroid nodule disease. Background Art

[0002] Disclosing the information of this background art is intended to increase the understanding of the overall background of the present invention, and it is not necessarily regarded as an admission or an indication in any form that this information constitutes the prior art already known to those of ordinary skill in the art.

[0003] Thyroid nodule (TN) is a common disease in the endocrine system. Its cause is the scattered lesions caused by the abnormal growth of thyroid cells locally, manifested as one or more masses with abnormal structures inside the thyroid. According to the clinical manifestations and pathological mechanisms of thyroid nodules, they are included in the category of "goiter" for identification and treatment. Chen Wuzhe said in "Three Causes and One Prescription Theory": "Goiter mostly appears on the shoulders and neck, and tumors coagulate with qi... Those that grow and shrink with emotions are called qi goiter." Thus, it can be seen that emotional factors are closely related to goiter. In the case of emotional disorders, anxiety and anger, it will lead to the stagnation of liver qi and the obstruction of its movement, making qi, blood and body fluids unable to be distributed normally, and then pathological changes such as qi stagnation, phlegm coagulation and blood stasis occur, thus triggering the disease. Therefore, the treatment should focus on soothing the liver and regulating qi, softening hardness and dissipating nodules. Summary of the Invention

[0004] Application of Periplaneta americana powder in drugs for treating thyroid nodule disease.

[0005] The Periplaneta americana powder is obtained by sterilizing, drying and pulverizing Periplaneta americana American cockroach (Linnaeus.) to obtain a fine powder.

[0006] A traditional Chinese medicine composition for treating thyroid nodules, comprising the following raw materials in parts by weight: 6 - 9 parts of Periplaneta americana, 3 - 10 parts of Bupleurum chinense, 6 - 10 parts of Cyperus rotundus, 3 - 9 parts of Pinellia ternata, 9 - 15 parts of Prunella vulgaris, 5 - 10 parts of Fritillaria thunbergii.

[0007] Preferably, the above traditional Chinese medicine composition comprises the following raw materials in parts by weight: 3 parts of Periplaneta americana, 3 parts of Bupleurum chinense, 3 parts of Cyperus rotundus, 2 parts of Pinellia ternata, 4 parts of Prunella vulgaris, 2 parts of Fritillaria thunbergii.

[0008] The traditional Chinese medicine composition is obtained by compatibility of Periplaneta americana with other traditional Chinese medicines. The other traditional Chinese medicines can be directly pulverized powders, or powders made after extraction, concentration and drying. The extraction is preferably water extraction.

[0009] A drug prepared from the above traditional Chinese medicine composition.

[0010] The drug can be in dosage forms such as powder, water pill, granule, tablet, capsule, etc.

[0011] The present invention has the following advantages: The present invention provides a new use of Periplaneta americana powder in medicine. Clinically, it is found that Periplaneta americana alone or in combination with other traditional Chinese medicines has good effects in treating thyroid nodules, providing a new direction for the development of the traditional Chinese medicine Periplaneta americana. Specific embodiments

[0012] The following further illustrates the present invention with reference to embodiments, but the present invention is not limited by the following embodiments.

[0013] Example 1 Preparation of Periplaneta americana powder capsules and their treatment of thyroid nodules Preparation of Periplaneta americana powder capsules: After Periplaneta americana is sterilized by moist heat and dried, it is pulverized into fine powder (passing through 80-mesh sieve), dry-pressed into granules (without adding excipients), filled into capsules, and each capsule contains 0.5 g of Periplaneta americana powder.

[0014] Diagnostic criteria: Imaging examination: Thyroid B-ultrasound examination shows that there is one or more nodules in the thyroid, excluding the possibility of external compression of surrounding organs and malignant tumors; Symptoms: The nodules can move up and down with swallowing, there is no redness, swelling, heat or pain in the nodules, and when the nodules are larger, there may be symptoms such as a feeling of neck traction and dyspnea; Physical signs: During thyroid examination, a mass and unilateral or bilateral thyroid enlargement are felt, and one or more nodules can be palpated on it, with clear boundaries, no tenderness, able to move up and down with swallowing, no tremor, and no vascular murmur; thyroid function is normal.

[0015] Case situation: According to the above diagnostic criteria, 30 patients were included, including 16 males and 14 females, 12 patients aged 20 - 60 years, and 18 patients over 60 years old, with an average age of 52.2 years.

[0016] Treatment method: Take 4 Periplaneta americana powder capsules each time, 3 times a day, and continuously take the medicine for 3 months.

[0017] Efficacy evaluation criteria: Clinical cure: The nodules basically disappear; Marked effect: The maximum diameter of the nodules is shortened by ≥50%; Effective: The maximum diameter of the nodules is shortened by 20% - 49%; Ineffective: The maximum diameter of the nodules is shortened by <20% or there is no change (for multiple nodules, as long as one of them increases compared with the previous one, it is ineffective). Clinical cure is judged as cured, and marked effect and effective are judged as improved.

[0018] Results: 6 cases were cured, 11 cases were improved, and 3 cases were ineffective, with a total effective rate of 90.0%.

[0019] Example 2 Preparation of compound water pills of Periplaneta americana and their treatment of thyroid nodules Preparation of Compound Pills of Periplaneta americana: After Periplaneta americana is sterilized by moist heat and dried, it is crushed into fine powder (passing through 80-mesh sieve) to obtain Periplaneta americana powder; Take 180 g of Bupleuri Radix, 180 g of Cyperi Rhizoma, 120 g of Pinelliae Rhizoma Praeparatum, 240 g of Prunellae Spica, and 120 g of Thunberg Fritillary Bulb, crush them into fine powder (passing through 80-mesh sieve), mix them with 180 g of Periplaneta americana powder, make pills with water, and dry them to obtain compound pills. The specification of the pills is that 10 pills weigh 1 g, and the packaging is 6 g per bag.

[0020] Case situation: According to the diagnostic criteria in Example 1, 40 patients were included, including 18 males and 22 females, 25 patients aged 20 - 60 years old, and 15 patients over 60 years old, with an average age of 49.6 years.

[0021] Treatment method: Take the prepared pills, 1 bag each time, 3 times a day, and continuously take the medicine for 3 months.

[0022] Result: 10 cases were cured, 27 cases improved, and 3 cases were ineffective, with a total effective rate of 92.5%.

[0023] Example 3 Preparation of Compound Capsules of Periplaneta americana and Its Treatment for Thyroid Nodules Preparation of Compound Capsules of Periplaneta americana: After Periplaneta americana is sterilized by moist heat and dried, it is crushed into fine powder (passing through 80-mesh sieve) to obtain Periplaneta americana powder; Take 180 g of Bupleuri Radix, 180 g of Cyperi Rhizoma, 120 g of Pinelliae Rhizoma Praeparatum, 240 g of Prunellae Spica, and 120 g of Thunberg Fritillary Bulb, decoct twice with water. Add 10 times the amount of water for the first time and 8 times the amount of water for the second time. Decoct for 2 hours each time, filter, combine the decoction liquids, concentrate the decoction liquid under reduced pressure to a clear paste with a relative density of 1.32 (60 °C). Add 180 g of Periplaneta americana powder to the clear paste, mix well, dry under reduced pressure, crush into fine powder, and fill into capsules. Each capsule contains 0.5 g, and the amount equivalent to the original medicinal materials is 1.5 g.

[0024] Case situation: According to the diagnostic criteria in Example 1, 38 patients were included, including 18 males and 20 females, 19 patients aged 20 - 60 years old, and 19 patients over 60 years old, with an average age of 60.2 years.

[0025] Treatment method: Take the prepared capsules, 4 capsules each time, 3 times a day, and continuously take the medicine for 3 months.

[0026] Result: 9 cases were cured, 17 cases improved, and 2 cases were ineffective, with a total effective rate of 94.7%.

[0027] Example 4 Preparation of Compound Granules of Periplaneta americana and Its Treatment for Thyroid Nodules Preparation of Compound Capsules of Periplaneta americana: After Periplaneta americana is sterilized by moist heat and dried, it is crushed into fine powder (passing through 80-mesh sieve) to obtain Periplaneta americana powder; Take 180 g of Bupleuri Radix, 180 g of Cyperi Rhizoma, 120 g of Pinelliae Rhizoma Praeparatum, 240 g of Prunellae Spica, and 120 g of Thunberg Fritillary Bulb. Decoct twice with water. For the first time, add 10 times the amount of water, and for the second time, add 8 times the amount of water. Decoct for 2 hours each time, filter, combine the decoction liquids, concentrate the decoction liquids under reduced pressure to a clear paste with a relative density of 1.32 (60 °C), dry under reduced pressure, and pulverize into fine powder (pass through an 80-mesh sieve). Mix 180 g of Periplaneta americana powder and the fine powder of the clear paste with an appropriate amount of sucrose powder, prepare granules, bag them, with a specification of 5 g per bag, and the amount equivalent to the original medicinal materials is 6 g.

[0028] Case situation: According to the diagnostic criteria in Example 1, 54 patients were included, including 24 males and 30 females. Among them, 25 patients were aged 20 - 60 years old, and 30 patients were over 60 years old. The average age was 59.6 years.

[0029] Treatment method: Take the prepared granules, 1 bag each time, 3 times a day, and continuously take the medicine for 3 months.

[0030] Results: 12 cases were cured, 37 cases improved, and 5 cases were ineffective. The total effective rate was 90.7%.

[0031] The above are only the embodiments of the present application and are not used to limit the present application. For those skilled in the art, various changes and modifications can be made to the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included within the scope of the claims of the present application.

Claims

1. Application of American cockroach powder in medicine for the treatment of thyroid nodule.

2. A Chinese medicine composition for treating thyroid nodules, characterized in that: The invention comprises the following raw materials in parts by weight: 6-9 parts of American cockroaches, 3-10 parts of bupleurum, 6-10 parts of cyperus rotundus, 3-9 parts of pinellia tuber, 9-15 parts of selfheal and 5-10 parts of thunbergia thunbergii.

3. The Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 3 parts of American cockroach, 3 parts of bupleurum, 3 parts of cyperus rotundus, 2 parts of pinellia tuber, 4 parts of selfheal, and 2 parts of thunbergia thunbergii.

4. A method for preparing the Chinese medicine composition according to claim 2 or 3, characterized in that: The raw materials other than the American cockroach are directly crushed or extracted, concentrated, dried, made into powders and then mixed with the powder of the American cockroach to obtain the powder.

5. The preparation method according to claim 4, characterized in that: The extraction is water extraction.

6. A medicine prepared from the Chinese medicine composition according to claim 2 or 3.

7. The drug according to claim 5, characterized in that The dosage form of the drug is selected from powder, water pill, granule, tablet or capsule.