Preparation system of tedizolid phosphate powder injection for injection

Abstract

The invention discloses a tedizolid phosphate powder injection preparation system for injection. The system comprises a PH value adjusting module, a liquid medicine collecting module, an atomizing and hot air spraying drying module and a quantitative powder discharging module. The PH value adjusting module comprises an adjusting sealing box, and a step-by-step fall liquid flowing box, an acidity adjusting spraying mechanism and an impurity removing mechanism are arranged in the box; the liquid medicine collection module comprises a centralized collection tank and an atomization persistence box; the atomizing and hot gas spraying drying module comprises a spray drying tank, a gas filtering part, a powder sweeping assembly, a hot drying gas pipeline, an atomizer and a diaphragm powder pump box; and the quantitative powder discharging module comprises a quantitative powder collecting barrel and a vibration motor mounted on the side wall of the quantitative powder collecting barrel. Flowing liquid medicine is utilized, titration of different degrees is carried out in different stages until final titration is carried out in the final stage, the titration precision is high, the liquid medicine can be continuously output, medicine powder is continuously removed, powder is not sprayed out but falls in a vibration mode, scattering and wall adhering are avoided, and the continuous production requirement is met.

Description

Technical Field

[0001] The present invention relates to the technical field of the preparation of tedizolid phosphate powder for injection, and particularly to a preparation system for tedizolid phosphate powder for injection. Background Art

[0002] Tedizolid phosphate is a new type of drug for anti-bacterial infection. In the process of the imitation and development of tedizolid phosphate for injection, it is also found that the reference preparation of tedizolid phosphate injection (freeze-dried powder injection) has relatively poor stability, high moisture content and high impurities in the long-term and accelerated stability tests. As is well known, the current freeze-drying process often faces the disadvantages of large equipment investment, high energy consumption, high product cost, complex production process, long production time and low output. Moreover, in the freeze-drying process, it often faces the process disadvantages that the water content in the production process is easy to exceed the standard, the appearance is unqualified (the shape is not plump or shrinks into agglomerates), the wall-hanging phenomenon is easy to occur during the filling process, the powder moisture is not evenly dried during the sublimation drying process, the spraying phenomenon is easy to occur, and the cold explosion and bottom detachment phenomenon of the product are easy to occur during decompression.

[0003] In terms of the current technology, the preparation of tedizolid phosphate powder for injection requires multiple steps of treatment, and then drying and powdering or freeze-drying and powdering. Continuous production cannot be carried out between the steps, and the product can only be taken after each step is completed to carry out the next reaction. Moreover, when the prepared powder is injected into a penicillin bottle, it is easy to cause the powder to float or stick to the wall, because the powder has an impact force when it is ejected, and the powder is blown into the bottle. It is easy to blow too much or too little, and it is also easy to be contaminated. Summary of the Invention

[0004] The present invention aims to solve at least one of the technical problems in the related technologies to some extent. For this reason, an object of the present invention is to provide a preparation system for tedizolid phosphate powder for injection, which solves the problems that continuous production cannot be carried out between steps, and when the powder is injected into a penicillin bottle, it is easy to cause the powder to float or stick to the wall, etc.

[0005] According to the preparation system for tedizolid phosphate powder for injection provided by the present invention, it includes a pH value adjustment module, a liquid medicine collection module, an atomization and hot air drying module and a quantitative powder output module;

[0006] The pH value adjustment module includes an adjustment seal box, a step-down liquid flow box arranged inside the box, an acidity adjustment spray mechanism and an impurity removal mechanism. The step-down liquid flow box includes a first liquid flow box, a second liquid flow box, a third liquid flow box, a fourth liquid flow box and a fifth liquid flow box. A spill-down flow channel is provided at a position near the top on the right side of the first liquid flow box, the second liquid flow box, the third liquid flow box and the fourth liquid flow box. An electronic acidity meter is provided in each of the first liquid flow box, the third liquid flow box and the fifth liquid flow box. A first lye spray head and a second lye spray head are respectively provided above the second liquid flow box and the fourth liquid flow box. A filter box is provided at a position below the spill-down flow channels of the second liquid flow box and the fourth liquid flow box at the top opening positions of the third liquid flow box and the fifth liquid flow box respectively. One side of the filter box is installed on a hanging plate, and an installation plug is provided at the top of the hanging plate. Spray heads for stabilizer and filler are also provided above the second liquid flow box and the fourth liquid flow box. A raw liquid medicine inlet pipe inserted into a position near the top of the first liquid flow box is provided at a position near the top on the left side of the adjustment seal box, and a liquid medicine discharge pipe inserted into the bottom of the fifth liquid flow box is provided at a position near the bottom on the right side;

[0007] The liquid medicine collection module includes a centralized collection tank and an atomization temporary storage box. The output end of the liquid medicine discharge pipe is connected to the top inside the centralized collection tank. A metering liquid pump is provided at the top of the centralized collection tank. The inlet pipe of the metering liquid pump is inserted into the inner bottom of the centralized collection tank, and the outlet pipe is inserted into the top inside the atomization temporary storage box. A plurality of micro liquid pumps are arranged in an array on the atomization temporary storage box. The inlet pipe of the micro liquid pump is inserted into the inner bottom of the atomization temporary storage box, and a hose is connected to the outlet pipe. A first air vent pipe and a second air vent pipe communicated with the inside are respectively connected to the tops of the centralized collection tank and the atomization temporary storage box;

[0008] The atomization and hot air drying module includes a spray drying tank, a filter element, a powder sweeping assembly, a hot drying gas pipeline, an atomizer, and a diaphragm powder pump box. The bottom of the spray drying tank is hemispherical, and a filter element is screwed to the top. The spray drying tank is provided with a circle of atomizers inserted into the tank along the wall on the side wall at the middle position. Below the circle of atomizers, there is a hot drying gas annular pipe. The inner side of the hot drying gas annular pipe is provided with a plurality of evenly distributed jet branch pipes, and the jet branch pipes are inserted into the spray drying tank. The inner end of the jet branch pipe in the spray drying tank is inclined obliquely upward. The hose on each micro liquid pump is correspondingly connected to an atomizer liquid inlet. The powder sweeping assembly includes a plurality of powder sticking plates, a powder sweeping brush, and a driving motor. Two powder sticking plates are respectively provided at intervals on the inner wall of the spray drying tank above and below the positions of the hot drying gas pipeline and the atomizer. A round hole is provided at the center position of the powder sticking plate. The driving motor is installed in a motor box below the filter element near the top in the spray drying tank, and the driving motor is arranged downward, and a driving long rod is connected to the rotating shaft. The middle of the driving long rod is sleeved with a bearing, and the bearing is fixed to the inner wall of the spray drying tank by a connecting rod. Four powder sweeping brushes are sleeved on the driving long rod, and each powder sweeping brush is attached to the upper surface of a powder sticking plate. The powder sticking plate is evenly provided with powder leakage holes. A powder discharge pipe is provided at the bottom of the spray drying tank, and the powder discharge pipe is connected to the diaphragm powder pump powder inlet in the diaphragm powder pump box;

[0009] The quantitative powder discharging module includes a quantitative powder collecting cylinder and a vibration motor installed on the side wall of the quantitative powder collecting cylinder. The quantitative powder collecting cylinder is provided with a quantitative pipeline near the bottom. The top of the quantitative pipeline is communicated with the inside of the quantitative powder collecting cylinder. A first plug board and a second plug board are respectively provided at the top and the bottom of the quantitative pipeline. Both the first plug board and the second plug board are installed on the cylinder shaft of a pulling cylinder. A third air vent pipe is provided at the top of the quantitative powder collecting cylinder. A powder quantity detector is provided at the inner top of the quantitative powder collecting cylinder. The top of the quantitative powder collecting cylinder is installed by a suspension rod. The powder outlet of the diaphragm powder pump is inserted into the quantitative powder collecting cylinder near the top through a pipeline.

[0010] In some embodiments of the present invention, the first lye spray head and the second lye spray head have the same structure and size. The spraying speed of the first lye spray head or the second lye spray head, added to the spraying speed of the stabilizer and filler spray heads set beside it and the overflowing liquid medicine speed from the first liquid flow box or the third liquid flow box, shall not be greater than the maximum overflowing liquid medicine speed of the overflowing downstream channel.

[0011] In some other embodiments of the present invention, the lye sprayed by the first lye spray head adjusts the alkalinity of the liquid medicine and makes the liquid medicine approach the required alkalinity. When the volume of the liquid medicine is V and it is necessary to spray V1 volume of lye to reach the liquid medicine with the required alkalinity type, the volume of the lye sprayed by the first lye spray head is 80% ± 5% V1 to neutralize V volume of the liquid medicine, and the second lye spray head sprays the remaining lye. The sum of the lye sprayed by the first lye spray head and the second lye spray head is 100% ± 5% V1 to neutralize V volume of the liquid medicine.

[0012] In some other embodiments of the present invention, filter membranes are provided in the first vent pipe, the second vent pipe and the third vent pipe, and the filter membranes are multi-layer gauzes.

[0013] In some other embodiments of the present invention, the air filtering member includes an inverted convex tube, a bacteria filtering gauze, a dust filtering glass plate and a cover. A circular dust filtering glass plate is plugged inside the bottom of the inverted convex tube, and the dust filtering glass plate is evenly provided with gas through holes. A bacteria filtering gauze is plugged inside the upper half of the inverted convex tube. The top of the inverted convex tube is blocked by a cover, and the cover is evenly provided with exhaust round holes.

[0014] In some other embodiments of the present invention, the powder sticking plate is a concave spherical panel, the powder sweeping brush is a concave arc brush, the concave arc of the arc brush matches the concave arc of the concave spherical panel, and the bristles of the powder sweeping brush are attached to the upper surface of the powder sticking plate.

[0015] In some other embodiments of the present invention, the bottom of the quantitative powder collecting cylinder is provided with a conical bottom, the bottom of the conical bottom is provided with a first cylindrical plug-in tube, the quantitative pipe is a conical pipe, the top of the quantitative pipe is connected with the bottom of the first cylindrical plug-in tube, the bottom of the quantitative pipe is provided with a second cylindrical plug-in tube, the bottom of the first cylindrical plug-in tube is provided with a powder feeding cone head, and a first plug and a second plug are respectively inserted on the first cylindrical plug-in tube and the second cylindrical plug-in tube.

[0016] In some other embodiments of the present invention, the volume of the gas sprayed by multiple gas jet branch pipes on the hot drying gas annular pipe into the spray drying tank per unit time is 5 - 15 times the volume of the atomized liquid medicine sprayed by all atomizers into the spray drying tank 5 per unit time.

[0017] In some other embodiments of the present invention, the diaphragm powder pump sprays powder into the quantitative powder collecting cylinder 8 once every other period of time, and the powder sprayed by the diaphragm powder pump into the quantitative powder collecting cylinder each time is enough for the powder injection amount of one group of penicillin bottle powder injection equipment for penicillin bottle powder injection.

[0018] In the present invention, for acid-base titration to the required pH value, it is generally concentrated titration. After the titration is completed, the liquid medicine is recovered. During the process, impurities such as sediment and floating substances are filtered. Continuous production cannot be achieved. Only after the titration is completed, filtration and collection are carried out, the tank body is cleaned, and waiting for the next group of titrations. The production cost is high, the production efficiency is low, the operation is troublesome, and continuous quantitative transportation cannot be carried out according to the needs of liquid medicine transportation to achieve continuous production of the production line. However, the present invention utilizes the flowing liquid medicine to carry out titrations to different degrees at different stages until the final titration is carried out in the last stage. The titration accuracy is high, the liquid medicine can be continuously output, waiting for the following production steps, and there is no need to clean the tank body in time.

[0019] In the spray drying tank, hot air drying can be continuously carried out to quantitatively remove the powder. During the powder accumulation process, it will not immediately enter the next step, but continue to be dried for a period of time. The newly removed powder will accumulate on the old powder, and the old powder will reduce the possibility of water absorption. Thus, the powder at the bottom will be very dry, and the powder discharged from the diaphragm powder pump meets the water content requirements. Moreover, the whole process matches the previous one. The titrated liquid medicine is continuously output in the front, and continuous hot air drying and powder removal are carried out in the back, meeting the requirements of continuous production.

[0020] Each time a quantitative powder is taken with a quantitative powder collection cylinder. Each time the powder is taken, the first plug board is opened and vibration is started once. The powder vibrates evenly and flows into the quantitative pipeline. Then the first plug board is closed, and wait for the penicillin bottle to reach directly below the quantitative pipeline (the distance is 3 - 5 mm). Then, the second plug board is opened for vibration. The powder does not spray out, but vibrates and falls, without scattering, sticking to the wall, or even floating powder. The powder falling is safer and the accuracy is also high. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used together with the embodiments of the present invention to explain the present invention and do not constitute a limitation to the present invention. In the drawings:

[0022] Figure 1 It is a schematic structural diagram of a preparation system for tedizolid phosphate for injection powder injection proposed by the present invention.

[0023] Figure 2 It is a schematic structural diagram of the internal section of the adjustment sealing box proposed by the present invention.

[0024] Figure 3 It is a schematic common structural diagram of the first liquid flow box to the fifth liquid flow box proposed by the present invention.

[0025] Figure 4 It is a schematic structural diagram of the internal section of the spray drying tank proposed by the present invention.

[0026] In the figure: 1. Adjusting seal box; 11. Original liquid medicine inlet pipe; 12. First lye spray head inlet pipe; 121. First lye spray head; 13. Stabilizer and filler spray head inlet pipe (the first one); 131 and 151. Stabilizer and filler spray heads; 14. Second lye spray head inlet pipe; 15. Stabilizer and filler spray head inlet pipe (the second one); 16. Impurity remover inlet pipe; 17. Liquid medicine discharge pipe; 100. Electronic pH meter; 10. First liquid flow box; 20. Second liquid flow box; 30. Third liquid flow box; 40. Fourth liquid flow box; 50. Fifth liquid flow box; 2. Installation plug; 21. Hanging plate; 22. Filter box; 3. Centralized collection tank; 31. Quantitative liquid pump; 32. First air vent pipe; 4. Atomization temporary storage box; 41. Second air vent pipe; 42. Micro liquid pump; 5. Spray drying tank; 51. Atomizer; 52. Hot drying gas annular pipe; 521. Jet branch pipe; 6. Air filter component; 61. Inverted convex pipe; 62. Dust filtering glass plate; 63. Bacteria filtering gauze; 64. Sealing cover; 7. Diaphragm powder pump box; 8. Quantitative powder collection cylinder; 80. Suspension rod; 81. Third air vent pipe; 82. Vibration motor; 83. Conical bottom; 831. First plug board; 84. Quantitative pipeline; 841. Second plug board; 9. Driving motor; 91. Driving long rod; 92. Sweeping brush; 93. Powder sticking board. Detailed implementation manners

[0027] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments.

[0028] As Figures 1-4 shown, a preparation system for tedizolid phosphate for injection powder injection proposed by the present invention includes a pH value adjustment module, a liquid medicine collection module, an atomization and hot air drying module, and a quantitative powder output module;

[0029] The pH value adjustment module includes an adjustment seal box 1, a step-by-step drop liquid flow box, an acidity adjustment spray mechanism and an impurity removal mechanism arranged inside the box. The step-by-step drop liquid flow box includes a first liquid flow box 10, a second liquid flow box 20, a third liquid flow box 30, a fourth liquid flow box 40 and a fifth liquid flow box 50. A overflow and downstream channel 101 is provided at a position near the top on the right side of the first liquid flow box 10, the second liquid flow box 20, the third liquid flow box 30 and the fourth liquid flow box 40. An electronic acidity meter 100 is provided inside each of the first liquid flow box 10, the third liquid flow box 30 and the fifth liquid flow box 50. A first lye spray head 121 and a second lye spray head 141 are respectively provided above the second liquid flow box 20 and the fourth liquid flow box 40. A filter box 22 is provided at a position below the overflow and downstream channels of the second liquid flow box 20 and the fourth liquid flow box 40 at the top opening positions of the third liquid flow box 30 and the fifth liquid flow box 50 respectively. One side of the filter box 22 is installed on a suspension plate 21, and an installation plug 2 is provided at the top of the suspension plate 21. Spray heads 131 and 151 for stabilizer and filler are also provided above the second liquid flow box 20 and the fourth liquid flow box 40. A raw liquid medicine inlet pipe 11 inserted into a position near the top of the first liquid flow box 10 is provided at a position near the top on the left side of the adjustment seal box 1, and a liquid medicine discharge pipe 17 inserted into the bottom inside the fifth liquid flow box 50 is provided at a position near the bottom on the right side;

[0030] The raw liquid medicine inlet pipe 1 can use the original solution of tedizolid phosphate prepared by the reaction of a reaction tank, or it can be a mixture of tedizolid phosphate and injection water. The tedizolid phosphate solution needs to be adjusted in acidity by adding lye. Since the titration adjustment can only collect the liquid medicine after completion and then proceed to the next step, generally one tank operation is carried out, which is troublesome. There are also impurities such as precipitates and floating flocs to be treated. In the present invention, the acidity of the first liquid flow box 10 is measured, and then an impurity remover is added (slowly dropped, matching the dropping speed of the added original solution). After flowing into the second liquid flow box 20, lye, stabilizer and filler are sprayed. The spraying amount is sprayed slowly and according to the flow rate. Then it flows into the third liquid flow box 30 together with the original solution, but it will pass through a filter box 22 to filter out impurities. After entering the fourth liquid flow box 40, lye, stabilizer and filler are sprayed again, and then it flows into the fifth liquid flow box 50 to filter out impurities, and finally flows out. More groups can also be sprayed and the impurities removed according to needs.

[0031] The liquid medicine collection module includes a centralized collection tank 3 and an atomization temporary storage tank 4. The output end of the liquid medicine discharge pipe 17 is connected to the inside of the top of the centralized collection tank 3. A metering liquid pump 31 is provided at the top of the centralized collection tank 3. The liquid inlet pipe of the metering liquid pump 31 is inserted into the bottom inside of the centralized collection tank 3, and the liquid outlet pipe is inserted into the top inside of the atomization temporary storage tank 4. A plurality of micro liquid pumps 42 are distributed in an array on the atomization temporary storage tank 4. The liquid inlet pipe of the micro liquid pump 42 is inserted into the bottom inside of the atomization temporary storage tank 4, and a hose is connected to the liquid outlet pipe. The tops of the centralized collection tank 3 and the atomization temporary storage tank 4 are respectively connected with a first air vent pipe 32 and a second air vent pipe 41 that communicate with the inside;

[0032] The centralized collection tank 3 can collect a large amount of alkalized and impurity-removed liquid medicine. The atomization temporary storage tank 4 is used for atomizing the liquid medicine and facilitating the installation of a plurality of micro liquid pumps 42.

[0033] The atomization and hot air drying module includes a spray drying tank 5, a filter element 6, a powder sweeping assembly, a hot drying gas pipeline 52, an atomizer 51, and a diaphragm powder pump box 7. The bottom of the spray drying tank 5 is hemispherical, and a filter element 6 is screwed on the top. An atomizer 51 inserted into the tank along the wall is provided on the side wall of the spray drying tank 5 at the middle position. Below the circle of atomizers 51, there is a hot drying gas annular pipe 52. A plurality of uniform jet branch pipes 521 are provided inside the hot drying gas annular pipe 52, and the jet branch pipes 521 are inserted into the spray drying tank 5. The inner end of the jet branch pipe 521 in the spray drying tank 5 is inclined obliquely upward. The hose on each micro liquid pump 42 is correspondingly connected to the liquid inlet of an atomizer 51. The powder sweeping assembly includes a plurality of powder sticking plates 93, a powder sweeping brush 92, and a driving motor 9. Two powder sticking plates 93 are respectively provided at intervals on the inner wall of the spray drying tank 5 above and below the positions of the hot drying gas pipeline 52 and the atomizer 51. A round hole is provided at the center position of the powder sticking plate 93. The driving motor 9 is installed in a motor box near the top filter element 6 inside the spray drying tank, and the driving motor 9 is installed in the motor box. The driving motor 9 is arranged downward, and a driving long rod 91 is connected to the rotating shaft. The middle of the driving long rod 91 is sleeved with a bearing, and the bearing is fixed to the inner wall of the spray drying tank 5 with a connecting rod. Four powder sweeping brushes 92 are sleeved on the driving long rod 91, and each powder sweeping brush 92 is attached to the upper surface of a powder sticking plate 93. Leakage powder holes are uniformly provided on the powder sticking plate 93. A powder discharge pipe is provided at the bottom of the spray drying tank 5, and the powder discharge pipe is connected to the diaphragm powder pump powder inlet inside the diaphragm powder pump box 7;

[0034] The atomizer 51 sprays atomized liquid medicine, which is mixed with the hot drying gas sprayed into by the hot drying gas annular pipe 52 to evaporate the liquid medicine and remove the powder. The liquid medicine adheres to the powder sticking plate 93 and will be dried with the hot air flow. The dust adheres, and the powder sticking plate 93 will automatically fall off, and the upper surface is regularly brushed off by the powder sweeping brush 92. Finally, it falls to the bottom of the spray drying tank 5, but the powder will not be discharged immediately, but will accumulate. The upper layer continues to be dried and the moisture is restored. The lower layer will not absorb water. The accumulated powder will be regularly sprayed into the quantitative powder collecting cylinder 8 by the diaphragm powder pump for continuous powder injection into the penicillin vials.

[0035] The quantitative powder discharging module includes a quantitative powder collecting cylinder 8 and a vibration motor 82 installed on the side wall of the quantitative powder collecting cylinder. A quantitative pipeline 84 is provided near the bottom of the quantitative powder collecting cylinder 8. The top of the quantitative pipeline 84 communicates with the inside of the quantitative powder collecting cylinder 8. A first plug board 831 and a second plug board 841 are respectively provided at the top and bottom of the quantitative pipeline 84. Both the first plug board 831 and the second plug board 841 are installed on the cylinder shaft of the pulling cylinder. A third air vent pipe 81 is provided at the top of the quantitative powder collecting cylinder 8. A powder quantity detector is provided at the inner top of the quantitative powder collecting cylinder 8. The top of the quantitative powder collecting cylinder 8 is installed by a suspension rod 80. The powder outlet of the diaphragm powder pump is inserted into the quantitative powder collecting cylinder 8 near the top through a pipeline.

[0036] Each time a fixed amount of powder is taken with the quantitative powder collecting cylinder. Each time the first plug board is opened, the vibration is started once, and the powder vibrates evenly and flows into the quantitative pipeline. Then, the first plug board is closed, and wait for the penicillin vial to reach directly below the quantitative pipeline (the distance is 3 - 5 mm). Then, the second plug board is opened for vibration. The powder does not spray out, but vibrates and falls, without scattering, sticking to the wall, or even floating powder. The powder falling is safer and has higher precision.

[0037] The entire system is controlled by a PLC system or a control server.

[0038] The structures and sizes of the first lye spray head 121 and the second lye spray head 141 are the same. The spraying speed of the lye sprayed by the first lye spray head 121 or the second lye spray head 141, together with the spraying speeds of the solution sprayed by the stabilizer and filler spray heads 131 and 151 set beside it, and then added to the overflowing liquid medicine speed of the first liquid flow box 10 or the third liquid flow box 30, shall not be greater than the maximum speed of the overflowing liquid medicine in the overflow downstream channel 101.

[0039] Ensure that the sprayed liquid and the flowing liquid in the liquid flow box will not overflow the overflow downstream channel 101.

[0040] The lye sprayed by the first lye spray head 121 adjusts the alkalinity of the liquid medicine and makes the liquid medicine approach the required alkalinity. When the volume of the liquid medicine is V and it is necessary to spray V1 volume of lye to reach the liquid medicine with the required alkalinity type, the volume of the lye sprayed by the first lye spray head 121 is 80% ± 5% V1 to neutralize V volume of the liquid medicine, and the second lye spray head 141 sprays the remaining lye. The sum of the lye sprayed by the first lye spray head 121 and the second lye spray head 141 is 100% ± 5% V1 to neutralize V volume of the liquid medicine.

[0041] Perform stepwise titration to adjust the alkalinity, with a higher progress, which is also convenient for adjusting when adding alkali to flowing liquid. If the progress is not high, the number of times of spraying lye can be increased, and the number of liquid flow boxes can be increased.

[0042] Filter membranes are provided in the first air vent pipe 32, the second air vent pipe 41 and the third air vent pipe 81, and the filter membranes are multi-layer gauzes, which are breathable and can prevent external bacteria from contaminating.

[0043] The air filtering member includes an inverted convex tube 61, a bacteria filtering gauze 63, a dust filtering glass plate 62 and a cover 64. A circular dust filtering glass plate 62 is plugged inside the bottom of the inverted convex tube 61, and gas permeation holes are uniformly provided on the dust filtering glass plate 62. A bacteria filtering gauze 63 is plugged inside the upper half of the inverted convex tube 61. The top of the inverted convex tube 61 is blocked by a cover 64, and exhaust round holes are uniformly provided on the cover 64.

[0044] The dust filtering glass plate 62 blocks the inflow of medicine powder. The bacteria filtering gauze 63 is convenient for buffering the gas flow and preventing bacteria from entering the air. If it is necessary to prevent medicine powder from accumulating between the bacteria filtering gauze 63 and the dust filtering glass plate 62, they can be stacked together.

[0045] The powder sticking plate 93 is a concave spherical panel, and the powder sweeping brush 92 is a concave arc brush. The concave arc of the arc brush matches the concave arc of the concave spherical panel. The bristles of the powder sweeping brush 92 are attached to the upper surface of the powder sticking plate 93. The concave arc is convenient for the powder to fall when brushing. If too much medicine powder sticks to the powder sticking plate 93 and is not easy to clean, a corresponding powder sweeping brush 92 can also be provided on the lower surface of the powder sticking plate 93.

[0046] The bottom of the quantitative powder collecting cylinder 8 is provided with a conical bottom 83. The bottom of the conical bottom 83 is provided with a first cylindrical plug-in tube. The quantitative pipeline 84 is a conical pipeline. The top of the quantitative pipeline 84 is connected to the bottom of the first cylindrical plug-in tube. The bottom of the quantitative pipeline 84 is provided with a second cylindrical plug-in tube. The bottom of the first cylindrical plug-in tube is provided with a powder feeding cone head 85. The first plug-in plate 831 and the second plug-in plate 841 are respectively inserted on the first cylindrical plug-in tube and the second cylindrical plug-in tube.

[0047] The bottom of the quantitative powder collecting cylinder 8 is provided with a conical bottom 83 to facilitate the aggregation and vibration of the medicinal powder and flow it into the quantitative pipeline 84. The quantitative pipeline 84 is conical to facilitate connection with the following powder feeding cone head 85, and the powder feeding cone head 85 is used to dock with the mouth of the penicillin bottle.

[0048] The volume of the gas ejected by multiple jet branch pipes on the hot drying gas annular pipe 52 into the spray drying tank 5 per unit time is 5 - 15 times the volume of the atomized liquid medicine ejected by all the atomizers 51 into the spray drying tank 5 per unit time. The large amount of hot gas results in a fast hot drying speed.

[0049] The diaphragm powder pump sprays powder into the quantitative powder collecting cylinder 8 at regular intervals, and the amount of powder sprayed by the diaphragm powder pump each time into the quantitative powder collecting cylinder is sufficient for the powder injection amount of a group of penicillin bottles when the penicillin bottle powder injection device rotates.

[0050] Preferably, the powder is sprayed into the quantitative powder collecting cylinder 8 once per group. Since there is a powder monitor, it can monitor the addition. The powder monitor is a distance measuring instrument (infrared). When the powder is almost sprayed, the distance between the powder surface and the distance measuring instrument will increase, thereby determining the powder content. However, it is not limited to the distance measuring instrument, and it can also be a pressure gauge. When the bottom powder does not press on it, the powder is replenished.

[0051] The above is only a preferred specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution and inventive concept of the present invention, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

Claims

1. A system for preparing tedizolid phosphate powder injection for injection, characterized in that: It includes a pH value adjustment module, a liquid medicine collection module, an atomization and hot air spray drying module, and a quantitative powder output module; The pH value adjustment module comprises an adjustment sealing box (1), a step-by-step drop liquid box arranged in the box, an acidity adjustment spray mechanism and an impurity removal mechanism, the step-by-step drop liquid box comprising a first liquid box (10), a second liquid box (20), a third liquid box (30), a fourth liquid box (40) and a fifth liquid box (50), the first liquid box (10), the second liquid box (20), the third liquid box (30) and the fourth liquid box (40) are each provided with an overflow lower flow channel (101) near the top on the right side, the first liquid box (10), the third liquid box (30) and the fifth liquid box (50) are each provided with an electronic acidity meter (100), the second liquid box (20) and the fourth liquid box (40) are each provided with a first alkali solution spray mechanism on the top. The third liquid flow box (30) and the fifth liquid flow box (50) are provided with a filter box (22) at the top opening below the overflow downflow channel of the second liquid flow box (20) and the fourth liquid flow box (40), respectively; one side of the filter box (22) is mounted on the hanging plate (21) and a mounting plug (2) is provided on the top of the hanging plate (21); a stabilizer and filler spray head (131) is also provided above the second liquid flow box (20) and the fourth liquid flow box (40); a raw liquid inlet pipe (11) inserted into the first liquid flow box (10) near the top is provided on the left side of the regulating sealing box (1), and a liquid discharge pipe (17) inserted into the bottom of the fifth liquid flow box (50) is provided on the right side near the bottom; The liquid medicine collection module comprises a centralized collection tank (3) and an atomization temporary retention box (4); the output end of the liquid medicine discharge pipe (17) is connected to the top of the centralized collection tank (3); a quantitative liquid pump (31) is arranged on the top of the centralized collection tank (3); the liquid inlet pipe of the quantitative liquid pump (31) is inserted into the bottom of the centralized collection tank (3); and the liquid outlet pipe is inserted into the top of the atomization temporary retention box (4); a plurality of micro liquid pumps (42) are arranged in an array on the atomization temporary retention box (4); the liquid inlet pipe of the micro liquid pump (42) is inserted into the bottom of the atomization temporary retention box (4); and a hose is connected to the liquid outlet pipe; the tops of the centralized collection tank (3) and the atomization temporary retention box (4) are respectively connected to a first air release pipe (32) and a second air release pipe (41) which are communicated with the inside; The atomization and hot air spray drying module comprises a spray drying tank (5), an air filter (6), a powder sweeping assembly, a hot drying gas pipeline (52), an atomizer (51) and a diaphragm powder pump box (7). The bottom of the spray drying tank (5) is in a hemispherical shape, and the air filter (6) is screwed on the top. The spray drying tank (5) is provided with a circle of atomizers (51) inserted into the tank along the wall on the side wall at the middle position. A hot drying gas annular pipe (52) is provided below the circle of atomizers (51). 52), a plurality of uniform jet branch pipes (521) are arranged on the inner side of the hot drying gas annular pipe (52), and the jet branch pipes (521) are inserted into the spray drying tank (5), and the jet branch pipes (521) are inclined upward at the inner end of the spray drying tank (5), and the hose on each of the micro liquid pumps (42) is connected to a corresponding liquid inlet of the atomizer (51), and the powder sweeping assembly includes a plurality of powder sticking plates (93), a powder sweeping brush (92) and a driving motor (9), and the plurality of The powder sticking plates (93) are provided with two spaced-apart powder sticking plates (93) on the inner wall of the spray drying tank (5) above and below the hot drying gas pipeline (52) and the atomizer (51), respectively. A circular hole is provided at the center of the powder sticking plates (93). The drive motor (9) is provided with a motor box below the air filter (6) near the top of the spray drying tank and the drive motor (9) is installed in the motor box. The drive motor (9) is provided downward and a drive motor is connected to the rotating shaft. A driving long rod (91), wherein the middle of the driving long rod (91) is sleeved with a bearing and the bearing is fixed to the inner wall of the spray drying tank (5) by a connecting rod, and four powder sweeping brushes (92) are sleeved on the driving long rod (91), and each of the powder sweeping brushes (92) is attached to the upper surface of a powder sticking plate (93), and the powder sticking plate (93) is evenly provided with powder leakage holes, and a powder discharge pipe is provided at the bottom of the spray drying tank (5), and the powder discharge pipe is connected to the powder inlet of the diaphragm powder pump in the diaphragm powder pump box (7); The quantitative powder discharge module comprises a quantitative powder collecting barrel (8) and a vibration motor (82) mounted on the side wall of the quantitative powder collecting barrel. A quantitative pipeline (84) is provided near the bottom of the quantitative powder collecting barrel (8). The top of the quantitative pipeline (84) is communicated with the inside of the quantitative powder collecting barrel (8). A first plug plate (831) and a second plug plate (841) are respectively provided at the top and bottom of the quantitative pipeline (84). The first plug plate (831) and the second plug plate (841) are both mounted on the cylinder shaft of the pulling cylinder. A third air discharge pipe (81) is provided at the top of the quantitative powder collecting barrel (8). A powder quantity detector is provided at the top of the quantitative powder collecting barrel (8). The top of the quantitative powder collecting barrel (8) is mounted with a suspension rod (80). The powder outlet of the diaphragm powder pump is inserted into the quantitative powder collecting barrel (8) near the top through a pipeline.

2. A system for preparing tedizolid phosphate powder injection for injection according to claim 1, characterized in that: The first alkali liquid spray head (121) and the second alkali liquid spray head (141) have the same structure and size. The sum of the alkali liquid spraying speed of the first alkali liquid spray head (121) or the second alkali liquid spray head (141) and the solution speed sprayed by the stabilizer and filler spray heads (131, 151) arranged next to it, and the speed of the liquid overflowing from the first liquid flow box (10) or the third liquid flow box (30) cannot be greater than the maximum speed of the liquid overflowing from the overflow lower flow channel (101).

3. A system for preparing tedizolid phosphate powder injection for injection according to claim 2, characterized in that: The alkali liquid sprayed by the first alkali liquid spray head (121) adjusts the alkalinity of the liquid medicine and makes the liquid medicine close to the required alkalinity. When the volume of the liquid medicine is V, and a volume of alkali liquid V1 needs to be sprayed to reach the required alkaline type of the liquid medicine, the volume of the alkali liquid sprayed by the first alkali liquid spray head (121) is 80%±5%V1 to neutralize the volume of the liquid medicine V, and the second alkali liquid spray head (141) sprays the remaining alkali liquid, and the sum of the alkali liquid sprayed by the first alkali liquid spray head (121) and the second alkali liquid spray head (141) is 100%±5%V1 to neutralize the volume of the liquid medicine V.

4. A system for preparing tedizolid phosphate powder injection for injection according to claim 1, characterized in that: The first air release pipe (32), the second air release pipe (41) and the third air release pipe (81) are all provided with filter membranes, and the filter membranes are multi-layer gauze.

5. A system for preparing tedizolid phosphate powder injection for injection according to claim 1, characterized in that: The air filter component comprises an inverted convex tube (61), a bacteria filtering gauze (63), a dust filtering glass plate (62) and a sealing cover (64); a circular dust filtering glass plate (62) is plugged into the bottom of the inverted convex tube (61), and the dust filtering glass plate (62) is evenly provided with gas perforations; a bacteria filtering gauze (63) is plugged into the upper half of the inverted convex tube (61); the top of the inverted convex tube (61) is sealed with a sealing cover (64), and the sealing cover (64) is evenly provided with exhaust circular holes.

6. A system for preparing tedizolid phosphate powder injection for injection according to claim 1, characterized in that: The powder sticking plate (93) is a concave spherical panel, and the powder sweeping brush (92) is a concave arc-shaped brush, the concave curvature of the arc-shaped brush matches the concave curvature of the concave spherical panel, and the bristles of the powder sweeping brush (92) are in contact with the upper surface of the powder sticking plate (93).

7. A system for preparing tedizolid phosphate powder injection for injection according to claim 1, characterized in that: The bottom of the quantitative powder collecting cylinder (8) is provided with a conical bottom (83), the bottom of the conical bottom (83) is provided with a first cylindrical plug-in plate cylinder, the quantitative pipe (84) is a conical pipe, the top of the quantitative pipe (84) is connected with the bottom of the first cylindrical plug-in plate cylinder, the bottom of the quantitative pipe (84) is provided with a second cylindrical plug-in plate cylinder, the bottom of the first cylindrical plug-in plate cylinder is provided with a powder casting cone (85), and the first cylindrical plug-in plate cylinder and the second cylindrical plug-in plate cylinder are respectively provided with a first plug-in plate (831) and a second plug-in plate (841).

8. The system for preparing tedizolid phosphate powder injection for injection according to claim 1, characterized in that: The volume of gas sprayed per unit time by the multiple jet branch pipes on the hot drying gas annular pipe (52) into the spray drying tank (5) is 5-15 times the volume of atomized liquid medicine sprayed per unit time by all atomizers (51) into the spray drying tank (5).

9. A system for preparing tedizolid phosphate powder injection for injection according to claim 1, characterized in that: The diaphragm powder pump sprays powder to the quantitative powder collecting cylinder (8) once at a certain interval, and the powder sprayed by the diaphragm powder pump to the quantitative powder collecting cylinder each time is enough to fill the penicillin bottle with powder for one group of penicillin bottle filling equipment.

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