Traditional Chinese medicine spray for promoting blood circulation to remove blood stasis and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, and particularly discloses a traditional Chinese medicine spray for promoting blood circulation to remove blood stasis and a preparation method thereof. The medicine is prepared from the following active ingredients in percentage by weight: 2.5%-10% of a traditional Chinese medicine extracting agent, 0.2%-1.5% of a thickening agent, 0.1%-0.2% of a surface transdermal agent, 0.01%-0.05% of a preservative, 0.5%-1.1% of an emulsifier, 1.2%-5% of a pH regulator, 2%-10% of 95% ethanol, 0.2%-1% of borneol and the balance of distilled water, according to the invention, through a method of synchronously combining low-temperature or constant-temperature grinding, multiple times of water extraction and alcohol extraction with reflux, the effective components of the medicine are fully extracted and retained in the liquid medicine, so that the utilization rate of the medicine is greatly improved, and the waste of the medicine is prevented; impurities are removed through multiple filtering and centrifuging methods, and the purity is improved. The preparation method is simple and low in cost, and the prepared spray is quick to absorb, has good effects of clearing and activating the channels and collaterals, relieving swelling and pain and promoting blood circulation to remove blood stasis, and is wide in application prospect.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a promoting blood circulation to remove blood stasis traditional Chinese medicine spray and a preparation method thereof. Background Art

[0002] Injuries caused by external forces such as falls, strikes, knocks, bumps and sports are called traumatic injuries. Traumatic injuries are mostly soft tissue injuries, manifested as bone and muscle injuries, blood stasis and swelling pain, disharmony of qi and blood, and blockage of meridians. Tissues that have suffered direct or indirect trauma and long-term strain will show microcirculation disorders. Due to the leakage or bleeding of the capillary wall, the formation of blood deposits in the tissue will occur, followed by aseptic inflammation, resulting in tissue swelling and pain. If the blood deposits are not promptly absorbed, symptoms such as tissue adhesion, ischemic contracture of muscles, and joint ankylosis will occur. Traumatic injuries can cause minor skin injuries or serious bone and muscle injuries. If the wound is contaminated or excessive bleeding occurs, it will lead to deficiency of qi and blood, and even damage to internal organs, endangering life.

[0003] The existing spray production technology generally uses frying, water extraction, and then alcohol extraction to prepare a mixed solution, but rarely conducts further purification. The impure preparation of the mixed solution will lead to serious waste of the final medicinal liquid, making it difficult for the medicinal properties to be completely dissolved in the mixed solution, resulting in insufficient medicinal effects; and because the traditional purification method does not adjust various numerical values such as the pH value of the relevant mixed solution, the transdermal permeability and stability of the medicinal liquid are difficult to guarantee, thus resulting in a significant decline in the medicinal effect of the medicinal liquid. In addition, there are also problems of difficult storage and serious waste of raw materials.

[0004] Therefore, we urgently need a promoting blood circulation to remove blood stasis spray that is convenient to carry, easy to use, and has stable and easily absorbable drug components to promote vasoconstriction at the affected area and reduce bleeding, and relieve the swelling and pain symptoms of patients. Summary of the Invention

[0005] The purpose of the present invention is to provide a promoting blood circulation to remove blood stasis traditional Chinese medicine spray and a preparation method thereof to solve the problems raised in the above background art.

[0006] To achieve the above purpose, the present invention provides the following technical solutions:

[0007] A promoting blood circulation to remove blood stasis traditional Chinese medicine spray, the raw materials of the active ingredients of the drug and their weight percentages include:

[0008] Traditional Chinese medicine extractant 2.5% - 10%, thickening agent 0.2% - 1.5%, surface transdermal agent 0.1% - 0.2%, preservative 0.01% - 0.05%, emulsifier 0.5% - 1.1%, pH regulator 1.2% - 5%, 95% ethanol 2% - 10%, borneol 0.2% - 1%, and the balance is distilled water;

[0009] The components and weight ratios of the traditional Chinese medicine extractant include 3 - 8 parts of Asarum sieboldii, 5 - 10 parts of Glycyrrhiza uralensis, 10 - 15 parts of Angelica sinensis, 5 - 10 parts of Scorpio, 5 - 10 parts of Bombyx batryticatus, 10 - 15 parts of Angelica dahurica, 10 - 15 parts of Lonicera japonica, 5 - 10 parts of Eupolyphaga seu Steleophaga, and 10 - 15 parts of Pueraria lobata.

[0010] Preferably, the thickener is one or a mixture of two of sodium carboxymethyl cellulose and microcrystalline cellulose, the surface transdermal agent is polysorbate - 80, the preservative is one or more of disodium edetate, disodium adenosine diphosphate, and disodium metronidazole phosphate, the emulsifier is sodium phosphate heptahydrate, and the pH regulator is used to adjust the pH of the promoting blood circulation and removing blood stasis traditional Chinese medicine spray to 5.2 - 6.8.

[0011] A preparation method of a promoting blood circulation and removing blood stasis traditional Chinese medicine spray, applicable to the promoting blood circulation and removing blood stasis traditional Chinese medicine spray proposed above, includes the following steps:

[0012] S1. Medicinal material preparation: Wash Asarum sieboldii, Glycyrrhiza uralensis, Angelica sinensis, Scorpio, Bombyx batryticatus, Angelica dahurica, Lonicera japonica, Eupolyphaga seu Steleophaga, and Pueraria lobata and air - dry them.

[0013] S2. Medicinal material powder making: Use grinding equipment to grind the medicinal materials in S1 into powder form respectively, and pass through a 100 - mesh sieve to form fine medicinal material powder.

[0014] S3. First - step boiling: Put the fine powder of Asarum sieboldii, Glycyrrhiza uralensis, Scorpio, Lonicera japonica, Eupolyphaga seu Steleophaga, and Pueraria lobata in the S2 fine medicinal material powder into the flask of the reflux device according to the ratio, add distilled water into the flask and soak for 1 - 2 days, then boil with strong fire, and then keep boiling with gentle fire. Use a filter screen to filter out the medicinal liquid to obtain the first medicinal liquid, and leave the first medicinal residue in the flask.

[0015] S4. Second - step boiling: Add distilled water to the casserole with the first medicinal residue in S3, boil with strong fire, and then decoct with gentle fire. Use a filter screen to filter out the medicinal liquid to obtain the second medicinal liquid.

[0016] S5. Reflux purification: Carry out reflux purification on the fine powder of Angelica sinensis, Bombyx batryticatus, and Angelica dahurica in the S2 fine medicinal material powder, then use a filter screen to filter out the medicinal liquid from the mixture of the medicinal powder and the medicinal liquid. After the medicinal liquid cools, add borneol with a volume ratio of 10%. After the borneol is completely dissolved in the medicinal liquid containing ethanol, obtain the third medicinal liquid.

[0017] S6. Mixed boiling: Put the first medicinal liquid in S3 and the second medicinal liquid in S4 into another casserole at the same time to form a mixed medicinal liquid. Heat the mixed medicinal liquid in the casserole with strong fire for concentration to obtain a concentrated medicinal liquid.

[0018] S7. Preliminary preparation: After the concentrated medicinal liquid in S6 cools, add a borneol solution, mix and stir evenly, and then mix it with the third medicinal liquid in S5 to make a traditional Chinese medicine preparation.

[0019] S8. Mixing and Preparation: Add a thickening agent, a surface transdermal agent, a preservative, and an emulsifier to the traditional Chinese medicine preparation in sequence and stir to mix. Finally, add a pH regulator to adjust the pH value to 5.2 - 6.8 to obtain a preliminary spray.

[0020] S9. Filtration and Purification: Subject the preliminary spray obtained in S8 to 1 - 3 times of suction filtration and 2 - 3 times of centrifugation at 4000 r / min to obtain a high - purity promoting blood circulation and removing stasis spray.

[0021] S10. Filling and Warehousing: Fill the prepared promoting blood circulation and removing stasis spray into bottles through a filling machine, then package the filled medicine through a packaging machine, and store it in a cool warehouse.

[0022] Preferably, in S2, the grinding equipment is specifically one of a low - temperature grinding equipment or a normal - temperature grinding equipment.

[0023] Preferably, in S3, the ratio of the fine powder of the medicinal material to distilled water is 1∶4 - 1∶6, and the time for decocting with slow fire is 60 - 120 minutes.

[0024] Preferably, in S4, the ratio of the first medicinal residue to distilled water is 1∶2 - 1∶3, and the time for decocting with slow fire is 30 - 60 minutes.

[0025] Preferably, in S5, the method of reflux purification is as follows:

[0026] (a) Add the medicinal powder to a round - bottom flask, place a long - neck funnel at the upper opening of the distillation head, and make the inclined plane at the lower opening of the long - neck funnel below the branch pipe of the distillation head.

[0027] (b) Pour 95% ethanol into the round - bottom flask (the volume of 95% ethanol added is 3 to 4 times the weight of the drug), and then add 1 - 2 pieces of zeolite (porous substance).

[0028] (c) Continuously heat with a magnetic electro - thermal mantle at a power of 220 w for 1 to 3 hours, and stir slowly at a low speed for 30 seconds every 5 minutes during this period.

[0029] Preferably, in S6, the time for heating with strong fire is 10 - 30 minutes.

[0030] Preferably, in S7, the borneol solution is formed by dissolving 95% ethanol and 10% borneol, and the amount of the borneol solution added is 2.2% - 11% of the weight of the mixed medicinal liquid.

[0031] Compared with the prior art, the beneficial effects of the present invention are:

[0032] (1) By grinding the medicinal materials into powder form, the contact area between the medicine and water is increased, preventing the active ingredients from becoming ineffective or volatilizing during the grinding process, which causes waste of the medicine and reduction of its efficacy. This makes it better dissolve in water. After boiling with gentle fire and strong fire, the first medicinal liquid and the second medicinal liquid are prepared, achieving the secondary utilization of traditional Chinese medicine, greatly releasing the efficacy of the medicine, and reducing the waste of traditional Chinese medicine. Finally, the two medicinal liquids are fused and concentrated and mixed with borneol solution, greatly retaining the efficacy of the medicinal liquid, and further removing impurities, ensuring the quality of purification while not losing the efficacy of the medicine.

[0033] (2) By refluxing the medicament, extracting its active ingredients and further separating and purifying them, the active ingredients are extracted to the maximum extent, and the alcohol-soluble active ingredients are fully extracted, further improving the quality of the traditional Chinese medicine preparation, maximizing the effect of traditional Chinese medicine. At the same time, before refluxing, borneol solution is mixed in the medicinal liquid, making the purification more sufficient during reflux, improving the purification efficiency and the quality of the traditional Chinese medicine preparation.

[0034] (3) By adding thickeners, surface transdermal agents, preservatives and emulsifiers and stirring and mixing, and finally adding pH regulators, the stability of the relevant transdermal properties, pH value, storage time, viscosity and emulsifying activity degree of the mixed liquid is ensured, further improving the quality of the traditional Chinese medicine preparation, extending the shelf life, and being beneficial to the stability of the effect of the traditional Chinese medicine preparation. Description of the Drawings

[0035] Figure 1 It is a flowchart for preparing a traditional Chinese medicine spray for promoting blood circulation and removing blood stasis according to the present invention. Detailed Embodiments

[0036] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0037] Embodiment:

[0038] A traditional Chinese medicine spray for promoting blood circulation and removing blood stasis, the raw materials of the active ingredients for preparing the medicine and their weight percentages include:

[0039] Traditional Chinese medicine extractant 10%, thickener 1.5%, surface transdermal agent 0.2%, preservative 0.05%, emulsifier 1.1%, pH regulator 5%, 95% ethanol 10%, borneol 1%, and the balance is distilled water;

[0040] The components and weight ratios of the traditional Chinese medicine extractant include 3-8 parts of Asarum sieboldii Miq., 5-10 parts of Glycyrrhiza uralensis Fisch., 10-15 parts of Angelica sinensis (Oliv.) Diels, 5-10 parts of Scorpio, 5-10 parts of Bombyx batryticatus, 10-15 parts of Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav., 10-15 parts of Lonicera japonica Thunb., 5-10 parts of Eupolyphaga seu Steleophaga, and 10-15 parts of Pueraria lobata (Willd.) Ohwi.

[0041] In one embodiment of the present invention, the thickener is one or a mixture of two of sodium carboxymethylcellulose and microcrystalline cellulose, the surface permeation enhancer is polysorbate-80, the preservative is one or more of disodium edetate, disodium adenosine diphosphate, and disodium metronidazole phosphate, the emulsifier is sodium phosphate heptahydrate, and the pH regulator is used to adjust the pH of the promoting blood circulation and removing blood stasis traditional Chinese medicine spray to 6.8.

[0042] A preparation method of a promoting blood circulation and removing blood stasis traditional Chinese medicine spray, applicable to the promoting blood circulation and removing blood stasis traditional Chinese medicine spray proposed above, includes the following steps:

[0043] S1. Medicinal material preparation: Wash Asarum sieboldii Miq., Glycyrrhiza uralensis Fisch., Angelica sinensis (Oliv.) Diels, Scorpio, Bombyx batryticatus, Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav., Lonicera japonica Thunb., Eupolyphaga seu Steleophaga, and Pueraria lobata (Willd.) Ohwi and air-dry them.

[0044] S2. Medicinal material powder preparation: Use a grinding device to grind the medicinal materials in S1 into powder form respectively, and pass through a 100-mesh sieve to form fine medicinal material powder.

[0045] S3. First boiling: Put the fine powder of Asarum sieboldii Miq., Glycyrrhiza uralensis Fisch., Scorpio, Lonicera japonica Thunb., Eupolyphaga seu Steleophaga, and Pueraria lobata (Willd.) Ohwi in the medicinal material fine powder in S2 into the flask of the reflux device according to the ratio, add distilled water into the flask and soak for 1-2 days, then boil with strong fire, and then keep boiling with slow fire. Use a filter screen to filter out the medicinal liquid to obtain the first medicinal liquid, and leave the first medicinal residue in the flask.

[0046] S4. Second boiling: Add distilled water to the casserole with the first medicinal residue remaining in S3, boil with strong fire, and then decoct with slow fire. Use a filter screen to filter out the medicinal liquid to obtain the second medicinal liquid.

[0047] S5. Reflux purification: Carry out reflux purification on the fine powder of Angelica sinensis (Oliv.) Diels, Bombyx batryticatus, and Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav. in the medicinal material fine powder in S2, and then use a filter screen to filter out the medicinal liquid from the mixture of medicinal powder and medicinal liquid. After the medicinal liquid cools, add borneol with a volume ratio of 10%. After the borneol is completely dissolved in the medicinal liquid containing ethanol, obtain the third medicinal liquid.

[0048] S6. Mixed boiling: Put the first medicinal liquid in S3 and the second medicinal liquid in S4 into another casserole at the same time to form a mixed medicinal liquid. Heat the mixed medicinal liquid in the casserole with strong fire for concentration to obtain a concentrated medicinal liquid.

[0049] S7. Preliminary preparation: After the concentrated medicinal liquid in S6 cools, add a borneol solution, mix and stir evenly, and then mix it with the third medicinal liquid in S5 to make a traditional Chinese medicine preparation.

[0050] S8. Mixing and Preparation: Add a thickening agent, a surface transdermal agent, a preservative, and an emulsifier to the traditional Chinese medicine preparation in sequence and stir and mix them. Finally, add a pH regulator to adjust the pH value to 5.2 - 6.8 to obtain a preliminary spray.

[0051] S9. Filtration and Purification: Subject the preliminary spray obtained in S8 to 1 - 3 times of suction filtration and 2 - 3 times of centrifugation at 4000 r / min to obtain a high - purity promoting blood circulation and removing blood stasis spray.

[0052] S10. Filling and Warehousing: Fill the prepared promoting blood circulation and removing blood stasis spray into bottles through a filling machine, then package the filled medicine through a packaging machine, and store it in a cool warehouse.

[0053] In an embodiment of this solution, in S2, the grinding equipment is specifically one of a low - temperature grinding equipment or a normal - temperature grinding equipment. In S3, the ratio of the fine powder of Chinese medicinal materials to distilled water is 1:6, and the simmering time is 120 minutes. In S4, the ratio of the first medicinal residue to distilled water is 1:3, and the simmering time is 60 minutes. In S6, the high - fire heating time is 30 minutes. In S7, the borneol solution is formed by dissolving 95% ethanol and 10% borneol, and the added amount of the borneol solution is 11% of the weight of the mixed medicinal liquid.

[0054] In an embodiment of this solution, in S5, the method of reflux purification is as follows:

[0055] (a) Add the medicinal powder to a round - bottom flask, place a long - necked funnel at the upper opening of the distillation head, and make the inclined plane at the lower opening of the long - necked funnel below the branch pipe of the distillation head.

[0056] (b) Pour 95% ethanol into the round - bottom flask (the added volume of 95% ethanol is 3 to 4 times the weight of the drug), and then add 1 - 2 zeolites (porous substances).

[0057] (c) Continuously heat with a magnetic electro - thermal mantle at a power of 220 w for 3 hours, and stir at a low speed for 30 seconds every 5 minutes during this period.

[0058] As can be seen from the above: By grinding the Chinese medicinal materials into powder form, the contact area between the drug and water is increased, preventing the effective components from being invalidated or volatilized during the grinding process, resulting in drug waste and reduced drug efficacy, and enabling it to better dissolve in water. After simmering with low - fire and high - fire to prepare the first medicinal liquid and the second medicinal liquid, the secondary utilization of traditional Chinese medicine is achieved, the drug efficacy is greatly released, and the waste of traditional Chinese medicine is reduced. By refluxing the medicine preparation, extracting its effective components and further separating and purifying them, the effective components are extracted to the maximum extent, and the alcohol - soluble effective components are fully extracted, further improving the quality of the traditional Chinese medicine preparation and maximizing the effect of traditional Chinese medicine.

[0059] Clinical trial:

[0060] Experimental example

[0061] 65 patients with acute soft tissue injuries were collected, including 44 males and 21 females. Regarding the condition, 15 cases were mild, 27 cases were moderate, and 23 cases were severe. They were randomly divided into an experimental group, control group one, and control group two. There were 22 cases in the experimental group, 22 cases in control group one, and 21 cases in control group two;

[0062] The experimental group used the above-mentioned traditional Chinese medicine spray for promoting blood circulation and removing blood stasis, externally applied once a day for a course of 7 days;

[0063] Control group one used Zheng Honghua Oil, externally applied once a day for a course of 7 days;

[0064] Control group two used the spray prepared by mixing the first liquid medicine and the second liquid medicine in S3 and S4, externally applied once a day for a course of 7 days;

[0065] After treatment, the average score comparison of pain, swelling, and dysfunction is as follows in the table:

[0066]

[0067]

[0068] After treatment, the comparison of the number of cases of treatment effects is as follows in the table:

[0069] Group Number of cases Cured Markedly effective Improved Ineffective Experimental group 22 5 14 2 1 Control group 1 22 3 8 9 2 Control group 2 21 4 10 6 1

[0070] Among them, the different score settings are as follows:

[0071] Swelling: Severe swelling, stretching of skin texture, shiny and tight skin, and even tension blisters appear, 6 points; Obvious swelling, but the skin texture is still smooth, with obvious depressions formed when pressed locally, 4 points; Slight local swelling, with no obvious depression when pressed locally, 2 points; No swelling, 0 points;

[0072] Pain: Obvious local pain, seriously affecting life and daily work, 6 points; Relatively obvious pain, still feeling pain in the static state, having a certain impact on life and daily work, 4 points; No obvious pain in the static state, feeling pain during activities, with local tenderness, having no obvious impact on life and daily work, 2 points; No obvious local tenderness, no obvious pain during activities, 0 points;

[0073] Dysfunction: Local pain, unbearable pain during activities, 6 points; No pain during small-scale local activities, obvious pain during large-scale activities but still tolerable, 4 points; Slight pain during local activities, 2 points; No obstacle, 0 points;

[0074] As can be seen from the above, in the experimental group using the traditional Chinese medicine spray for promoting blood circulation and removing blood stasis, the improvement in swelling and pain is better than that of the control group one using safflower oil, and the treatment effect is also better than that of the control group;

[0075] At the same time, combined with the control group two, it can be concluded that in the traditional Chinese medicine spray for promoting blood circulation and removing blood stasis, the alcohol extract composed of Angelica sinensis, Bombyx batryticatus, and Angelica dahurica is more important in the treatment of soft tissue injuries.

[0076] Among the above-mentioned drugs, among them:

[0077] Flos Lonicerae: It is the flower bud of Lonicera japonica Thunb. of the family Caprifoliaceae. Its main indications are febrile diseases, heat-toxic dysentery, carbuncles, sores, scrofula, hemorrhoids, and it has the function of clearing heat and detoxifying, and is a heat-clearing and detoxifying medicine. Flos Lonicerae has antibacterial, antiviral, antipyretic, anti-inflammatory, immune-enhancing, anti-tumor, anti-allergic, liver-protecting, cholagogue, and hypoglycemic effects. The organic acids it contains can regulate blood lipids, inhibit platelet aggregation and thrombus formation.

[0078] Angelica sinensis: It is the dried root of Angelica sinensis (Oliv.) Diels of the family Umbelliferae. Its main indications are irregular menstruation, amenorrhea and abdominal pain, mass accumulation, metrorrhagia and metrostaxis; headache due to blood deficiency, dizziness, flaccidity and paralysis; constipation due to intestinal dryness, tenesmus after dysentery; carbuncles, sores and boils, traumatic injuries, replenishing blood and promoting blood circulation, regulating menstruation and relieving pain, moistening the intestines and relaxing bowel movements, promoting bone marrow hematopoietic function, promoting the production of hemoglobin and red blood cells, having a dual regulatory effect on the uterus, and enhancing immune function; it can dilate coronary arteries, resist myocardial ischemia, anti-arrhythmia, dilate blood vessels, improve peripheral circulation, lower blood pressure, inhibit platelet aggregation, and anti-thrombosis; it has antioxidant, inhibits cholesterol synthesis in the liver, reduces blood lipids, protects the liver, relieves pain, sedates, anti-tumor, and antibacterial effects.

[0079] Angelica dahurica: It is the dried root of Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan or Angelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. of the family Umbelliferae. Its main indications are headache, pain in the supraorbital ridge, toothache, nasal sinusitis, cold-damp abdominal pain, intestinal wind and hemorrhoids, leukorrhea, carbuncles and sores, dry skin itching, scabies. It dispels wind, dries dampness, reduces swelling, and relieves pain.

[0080] Radix Puerariae: This product is the dried root of Pueraria lobata (Willd.) Ohwi or Pueraria thomsonii Benth. of the family Leguminosae. Its main indications are typhoid fever, headache and stiffness of the nape in warm febrile diseases, vexation and thirst, diarrhea, dysentery, failure of macules to come out, hypertension, angina pectoris, deafness, lifting yang and relieving muscle spasms, promoting eruption and relieving diarrhea, removing vexation and relieving fever. It treats typhoid fever, headache and stiffness of the nape in warm febrile diseases, vexation and thirst, diarrhea, dysentery, failure of macules to come out, hypertension, angina pectoris, deafness.

[0081] Asarum sieboldii Miq.: Its main indications are headache due to wind-cold, nasal sinusitis, toothache, cough and counterflow due to phlegm retention, rheumatic arthralgia. It dispels wind, disperses cold, promotes diuresis, and opens orifices. It treats headache due to wind-cold, nasal sinusitis, toothache, cough and counterflow due to phlegm retention, rheumatic arthralgia.

[0082] Licorice: It is used for weakness of the spleen and stomach, lassitude and weakness, palpitation and shortness of breath, cough with profuse phlegm, abdominal pain and spasms in the abdomen and limbs, carbuncles and sores, to relieve the toxicity and potency of drugs, tonify the spleen and replenish qi, relieve cough and resolve phlegm, relieve spasm and relieve pain, and harmonize the properties of drugs. Licorice, a qi-tonifying drug under the classification of tonics for deficiency, has the effects of adrenocortical hormones, anti-inflammatory, anti-ulcer, anti-allergic reaction, anti-cancer, antibacterial, antiviral, promoting pancreatic juice secretion, inhibiting the isolated intestine, regulating immune function, relieving cough and resolving phlegm, anti-mutation, detoxification, antioxidant, protecting the function of the ear vestibule, diuretic, protecting the liver, preventing arteriosclerosis, anti-cerebral ischemia, preventing diabetic complications, etc.

[0083] Ground Beetle: It is the dried female body of the insect Eupolyphaga sinensis or Steleophaga plancyi of the family Polyphagidae. It is a precious cold-natured traditional Chinese medicine, salty, cold, and poisonous. It can remove blood stasis, break up accumulations, dredge collaterals, and regulate injuries. It has the effects of treating amenorrhea, postpartum blood stasis abdominal pain, traumatic injury, etc.; Ground beetle contains high protein and low fat, can prevent various diseases, and has good edible value. It is used for fracture injuries of tendons and bones, blood stasis amenorrhea, mass in the abdomen. The main indications are to break up blood stasis and continue the tendons and bones. It is used for fracture injuries of tendons and bones, blood stasis amenorrhea, mass in the abdomen.

[0084] Scorpion: It is the dried whole body of the scorpion Buthus martensii Karsch of the family Buthidae. It is used for infantile convulsions, twitching and spasm, deviation of the mouth and eyes due to stroke, hemiplegia, tetanus, stubborn rheumatism, one-sided headache, sores and ulcers, scrofula. It has the effects of calming endogenous wind and relieving spasm, attacking toxins and dissipating nodules, dredging collaterals and relieving pain.

[0085] Although the embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine spray for promoting blood circulation and removing blood stasis, characterized in that: The raw materials and their weight percentages of the active ingredients of the drug include: Chinese medicine extract 2.5%-10%, thickener 0.2%-1.5%, surface transdermal agent 0.1%-0.2%, preservative 0.01%-0.05%, emulsifier 0.5%-1.1%, pH adjuster 1.2%-5%, 95% ethanol 2%-10%, borneol 0.2%-1%, the balance is distilled water; The components and weight ratios of the traditional Chinese medicine extract include 3-8 parts of asarum, 5-10 parts of liquorice, 10-15 parts of angelica, 5-10 parts of scorpion, 5-10 parts of bombyx batryticatus, 10-15 parts of angelica dahurica, 10-15 parts of honeysuckle, 5-10 parts of earthworms, and 10-15 parts of kudzu root.

2. A Chinese medicine spray for promoting blood circulation and removing blood stasis according to claim 1, characterized in that: The thickener is one or a mixture of sodium carboxymethyl cellulose and microcrystalline cellulose, the surface transdermal agent is polysorbate 80, the preservative is one or more of disodium edetate, disodium adenosine diphosphate, and metronidazole disodium phosphate, the emulsifier is sodium phosphate heptahydrate, and the pH regulator is used to adjust the pH of the blood-activating and blood-stasis-removing Chinese medicine spray to 5.2-6.

8.

3. A method for preparing a blood-activating and stasis-removing Chinese medicine spray, applicable to the blood-activating and stasis-removing Chinese medicine spray as claimed in claims 1-2, characterized in that: The following steps are involved: S1. Preparation of medicinal materials: Wash and air-dry Asarum, Licorice, Angelica, Scorpio, Bombyx Batryticatus, Angelica Dahurica, Honeysuckle, Earthworm, and Pueraria; S2, medicinal material powder making: using a grinding device to grind the Chinese medicinal materials in S1 into powder respectively, and passing through a 100-mesh sieve to form medicinal material fine powder; S3, the first step of boiling: put the fine powders of asarum, licorice, scorpion, honeysuckle, earthworm and kudzu root in the fine powder of S2 medicinal materials into the flask of the reflux device according to the proportion, add distilled water into the flask and soak for 1-2 days, then boil with high heat, and then keep boiling with low heat, filter out the medicinal liquid with a filter to obtain the first medicinal liquid, so that the first medicinal residue remains in the flask; S4, the second step of boiling: adding distilled water to the casserole with the first medicinal residue remaining in S3, boiling it with high heat, then decocting it with low heat, filtering the medicinal liquid with a filter to obtain a second medicinal liquid; S5, reflux purification: reflux and purify the fine powders of Chinese angelica, silkworm and angelica dahurica in the fine powders of the medicinal materials in S2, and then filter out the medicinal liquid by using a filter screen from the mixture of the medicinal powders and the medicinal liquid, and add 10% by volume of borneol after the medicinal liquid is cooled, and after the borneol is completely dissolved in the medicinal liquid containing ethanol, obtain a third medicinal liquid; S6, mixing and boiling: placing the first medicinal liquid in S3 and the second medicinal liquid in S4 into another casserole at the same time to form a mixed medicinal liquid, heating the mixed medicinal liquid in the casserole with high heat to concentrate it to obtain a concentrated medicinal liquid; S7, preliminary preparation: after the concentrated medicinal solution in S6 is cooled, borneol solution is added, mixed and stirred evenly, and then mixed with the third medicinal solution in S5 to prepare a traditional Chinese medicine preparation; S8, mixing preparation: adding a thickener, a surface transdermal agent, a preservative and an emulsifier to the traditional Chinese medicine preparation in sequence and stirring and mixing, and finally adding a pH adjuster to adjust the pH value to 5.2-6.8 to obtain a preliminary spray; S9, filtration and purification: the preliminary spray obtained in S8 is filtered 1-3 times and centrifuged 2-3 times at 4000 r / min to obtain a high-purity blood-activating and blood-stasis-removing spray; S10, filling and warehousing: the prepared blood-activating and stasis-removing spray is filled into bottles by a filling machine, and then the filled medicine is packaged by a packaging machine and stored in a cool warehouse.

4. The method for preparing a blood-activating and blood-stasis-removing Chinese medicine spray according to claim 3, characterized in that: In S2, the grinding equipment is specifically one of a low-temperature grinding equipment and a normal-temperature grinding equipment.

5. The method for preparing a blood-activating and blood-stasis-removing Chinese medicine spray according to claim 1, characterized in that: In S3, the ratio of the fine powder of medicinal materials to distilled water is 1:4-1:6, and the decocting time is 60-120 minutes.

6. The method for preparing a blood-activating and stasis-removing Chinese medicine spray according to claim 3, characterized in that: In S4, the ratio of the first medicinal residue to distilled water is 1:2-1:3, and the decocting time is 30-60 minutes.

7. The method for preparing a blood-activating and stasis-removing Chinese medicine spray according to claim 3, characterized in that: In the S5, the method of reflux purification is: (a) Add the drug powder into a round-bottom flask and place a long-necked funnel on the top of the distillation head so that the slope at the bottom of the long-necked funnel is below the branch pipe of the distillation head; (b) Pour 95% ethanol into a round-bottom flask (the volume of 95% ethanol added is 3 to 4 times the weight of the drug), and then add 1-2 zeolites (porous substances); (c) Continuously heat with a magnetic heating mantle at 220 W for 1 to 3 hours, stirring at a low speed for 30 seconds every 5 minutes.

8. The method for preparing a blood-activating and stasis-removing Chinese medicine spray according to claim 3, characterized in that: In S6, the high heat heating time is 10-30 minutes.

9. The method for preparing a blood-activating and stasis-removing Chinese medicine spray according to claim 3, characterized in that: In the step S7, the borneol solution is prepared by dissolving 95% ethanol and 10% borneol, and the amount of the borneol solution added is 2.2%-11% of the weight of the mixed liquid medicine.

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