Targeted therapy device for multiple myeloma

Abstract

The targeted therapy device comprises a needle cylinder and a piston rod arranged in the needle cylinder, the bottom of the needle cylinder is detachably connected with a needle head, the bottom of the piston rod extends into the needle cylinder and then is integrally connected with a piston, the interior of the piston rod is hollow, and an inner rod is assembled in the piston rod; a sealing block is arranged at the communicating position of the piston and the interior of the piston rod, a second one-way valve is installed in the center of the sealing block, negative pressure is generated in the needle head by driving the inner rod to move towards the exterior in the piston rod, and air in the needle head enters the piston rod through the second one-way valve. Air in the needle head enters the piston rod through the second one-way valve by pulling the inner rod firstly, and during injection, the second one-way valve prevents the air in the piston rod from entering the needle cylinder, so that the air in the needle head is completely exhausted firstly, and the situation that part of liquid medicine is wasted due to exhaust of the air is avoided.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and particularly to a targeted treatment device for multiple myeloma. Background Art

[0002] For the treatment of multiple myeloma, the most common current treatment method is to directly deliver the targeted drug into the blood through intravenous injection, so that the drug can take effect faster. In the specific operation process, the doctor first pulls the piston rod of the syringe outwards to suck the drug into the syringe barrel, and then injects the drug into the patient's blood through intravenous injection. However, when pulling the piston rod to suck the drug into the syringe barrel, since there is air inside the needle part, the liquid medicine will be mixed with the air and enter the syringe barrel. In order to avoid injecting air into the patient's body, the doctor usually inverts the syringe barrel (with the needle pointing upwards), and then pushes the piston rod into the syringe barrel to discharge the air inside the syringe barrel. And in order to completely discharge the air, usually some liquid medicine will also be discharged from the needle. This not only makes the doctor's operation troublesome, but also causes waste of the drug. Summary of the Invention

[0003] In order to solve the technical problems existing in the above-mentioned prior art, the present invention provides a targeted treatment device for multiple myeloma.

[0004] To achieve the above object, the present invention provides the following technical solution: A targeted treatment device for multiple myeloma, including a syringe barrel and a piston rod disposed inside the syringe barrel. The bottom of the syringe barrel is detachably connected with a needle. The bottom of the piston rod extends into the syringe barrel and is integrally formed with a piston. The inside of the piston rod is hollow and is equipped with an inner rod. A sealing block is provided at the connection between the piston and the inside of the piston rod. A second one-way valve is installed at the center of the sealing block. By driving the inner rod to move towards the outside inside the piston rod, a negative pressure is generated inside the needle, and the air inside it enters the piston rod through the second one-way valve.

[0005] Preferably, the top of the piston rod is connected with a transmission box. The inner rod extends upwards through the outside of the transmission box and is fixedly connected with a pressing handle. External threads are formed on the circumferential surface of the inner rod, and internal threads adapted to the external threads are formed on the inner wall of the piston rod, and the length of the internal threads is greater than that of the external threads.

[0006] Preferably, a limiting block is also fixedly connected to the circumferential surface of the inner rod. The diameter of the limiting block is greater than that of the inner rod, and a limiting groove for the limiting block to slide is formed inside the piston rod.

[0007] Preferably, the interior of the sealing block is hollow, and a through hole is opened on the side wall of the sealing block along its radial direction, the through hole is connected to the interior of the sealing block, and an exhaust channel is opened inside the piston, one end of the exhaust channel is connected to the through hole, and the other end extends to the outside of the piston to communicate with the outside world, and a first one-way valve is installed inside the through hole.

[0008] Preferably, two second gears of the same specifications are symmetrically installed inside the transmission box with the inner rod as the center. The two second gears are rotatably connected to the transmission box. A first gear meshing with the two second gears is fixedly sleeved on the circumferential surface of the inner rod. The thickness of the first gear is smaller than that of the second gear. A connecting rod is fixedly connected to the centers of the two second gears along their axial direction. The connecting rod extends downward through the outside of the transmission box and is laterally fixed with a limiting rod. A flange is formed at the top edge of the syringe, and a limiting hole matching the shape of the limiting rod is opened on the flange. In the initial state, the limiting rod and the limiting hole are misaligned at a certain angle.

[0009] Preferably, the difference between the thickness of the first gear and the second gear is consistent with the length of the limiting groove.

[0010] Preferably, a motor is embedded and fixed at the bottom of the inner rod, a telescopic rod is fixedly connected to the output end of the motor, a hollow frame is installed at the top center of the sealing block, and the end of the telescopic rod is fixedly connected to the center of the hollow frame.

[0011] Preferably, a timing module is embedded in the bottom of the inner rod, and the timing module is used to record the time when the bottom of the inner rod is separated from the top of the sealing block. The motor is controlled by the timing module to drive the inner rod to rotate for resetting.

[0012] Compared with the prior art, the present invention provides a targeted treatment device for multiple myeloma, which has the following beneficial effects: Before inhaling the medicine, the present invention first pulls the inner rod to allow the air inside the needle to enter the piston rod through the second one-way valve, controls the movement distance of the inner rod so that the medicine fills the needle but does not enter the piston rod, and then pulls the piston rod to inhale the medicine. During injection, the second one-way valve prevents the air in the piston rod from entering the syringe, so that the air inside the needle is first discharged, avoiding the situation in the prior art where part of the medicine is wasted due to the discharge of air.

[0013] The design of the first gear, the second gear in the transmission box and the limit rod and the limit hole on the flange of the syringe is that the limit rod and the limit hole are misaligned in the initial state, and the piston rod cannot move by directly pulling it. The pressure handle must be operated first, which ensures that the air inside the needle can be discharged before use, avoiding misoperation caused by the doctor forgetting to operate the pressure handle.

[0014] The bottom of the inner rod is pre-embedded with a motor and a telescopic rod that cooperate with a timing module. When a person forgets to manually reset the inner rod after injection is completed, the timing module sends a signal to the motor after a set time. The motor drives the telescopic rod to rotate. Since the end of the telescopic rod is fixed to the sealing block, it acts on the inner rod in the opposite direction to make it rotate back to the initial state, ensuring that the device can exhaust air normally during the next use, and improving the reliability and convenience of the device. Description of the Drawings

[0015] The drawings are used to provide a further understanding of the present invention and constitute a part of the specification. They are used together with the embodiments of the present invention to explain the present invention and do not constitute a limitation to the present invention. In the drawings: Figure 1 is a three-dimensional structural schematic diagram of the entire device in the embodiment; Figure 2 is a structural schematic diagram of the piston rod in the embodiment; Figure 3 is a structural schematic diagram of the inside of the piston rod and the inside of the transmission box in the embodiment; Figure 4 is Figure 3 the front view structural schematic diagram in Figure 5 is a connection schematic diagram between the bottom of the inner rod and the sealing block in the embodiment; Figure 6 is a structural schematic diagram of the inside of the sealing block in the embodiment.

[0016] In the figures: 1, syringe barrel; 2, needle; 3, flange; 4, limit hole; 5, piston rod; 6, transmission box; 7, pressing handle; 8, piston; 9, limit rod; 10, second gear; 11, first gear; 12, inner rod; 13, external thread; 14, limit groove; 15, sealing block; 16, motor; 17, telescopic rod; 18, exhaust passage; 19, hollow frame; 20, through hole; 21, first one-way valve; 22, second one-way valve; 23, limit block. Detailed Embodiments

[0017] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Usually, the components of the embodiments of the present invention described and shown in the drawings here can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present invention provided in the drawings is not intended to limit the scope of the present invention claimed, but only represents the selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative efforts belong to the scope of protection of the present invention.

[0018] AsFigures 1-6 As shown in the figure, this embodiment proposes a targeted therapy device for multiple myeloma, which includes a syringe 1 and a piston rod 5 disposed inside the syringe 1. The bottom of the syringe 1 is detachably connected to a needle 2. The bottom of the piston rod 5 extends into the syringe 1 and is integrally formed with a piston 8. The diameter of the piston 8 is consistent with the inner diameter of the syringe 1, and the piston 8 is made of rubber material, which can not only meet the sealing requirements but also slide smoothly inside the syringe 1. The inside of the piston rod 5 is hollow and is equipped with an inner rod 12. A sealing block 15 is provided at the connection between the piston 8 and the inside of the piston rod 5. A second one-way valve 22 is installed at the center of the sealing block 15. When sucking the drug into the syringe 1, the needle 2 is immersed in the liquid medicine. First, the piston rod 5 remains stationary, and the inner rod 12 is pulled upward. The inner rod 12 slides inside the piston rod 5. Under the action of the second one-way valve 22, the air inside the needle 2 enters the cavity of the piston rod 5, and then the liquid medicine enters the needle 2. By controlling the moving distance of the inner rod 12, the liquid medicine can just fill the entire needle 2 but does not enter the piston rod 5. Then the inner rod 12 remains fixed, and then the piston rod 5 is pulled to slide towards the outside of the syringe 1, and the liquid medicine will continuously flow into the syringe 1. During the injection of the liquid medicine, due to the one-way conduction function of the second one-way valve 22, the air in the cavity of the piston rod 5 will not enter the syringe 1. Through this design, all the air inside the needle 2 is discharged first, and the waste of the liquid medicine can be avoided.

[0019] Regarding the movement of the inner rod 12 inside the piston rod 5, in this embodiment, a transmission box 6 is connected to the top of the piston rod 5. The inner rod 12 extends upward through the outside of the transmission box 6 and is fixedly connected to a pressing handle 7. An external thread 13 is formed on the circumferential surface of the inner rod 12 (the length and the position of the external thread 13 are not specifically limited in this embodiment). An internal thread adapted to the external thread 13 is formed on the inner wall of the piston rod 5, and the length of the internal thread must be greater than that of the external thread 13 to ensure that the external thread 13 and the internal thread can always cooperate during the entire movement of the inner rod 12. The operator operates the pressing handle 7 to drive the inner rod 12 to rotate counterclockwise, and the inner rod 12 moves towards the outside of the piston rod 5. At this time, the second one-way valve 22 opens, and a negative pressure is formed inside the needle 2 to make the liquid medicine enter. A limiting block 23 is also fixedly connected to the circumferential surface of the inner rod 12. The diameter of the limiting block 23 is larger than that of the inner rod 12. A limiting groove 14 for the limiting block 23 to slide is formed inside the piston rod 5. The moving distance of the inner rod 12 is limited by setting the length of the limiting groove 14. When the limiting block 23 moves from the bottom to the top of the limiting groove 14, the liquid medicine can just fill the entire needle 2.

[0020] ​After the injection is completed, the pressing handle 7 needs to be rotated clockwise to reset the inner rod 12 for the next use. However, due to the presence of the second one-way valve 22, when the inner rod 12 moves into the piston rod 5, the gas inside the piston rod 5 cannot be discharged smoothly. In view of this, in this embodiment, a through hole 20 is radially formed in the side wall of the sealing block 15 (as Figure 6 shown, the inside of the sealing block 15 is hollow, and the second one-way valve 22 is installed at its bottom), the through hole 20 is communicated with the inside of the sealing block 15, an exhaust passage 18 is formed inside the piston 8, one end of the exhaust passage 18 is communicated with the through hole 20, and the other end extends to the outside of the piston 8 to communicate with the outside. And a first one-way valve 21 is installed inside the through hole 20. When the inner rod 12 moves downward inside the piston rod 5, the second one-way valve 22 is in a closed state at this time, while the first one-way valve 21 is in an open state, and the air inside the piston rod 5 is discharged through the through hole 20 and the exhaust passage 18, finally enabling the inner rod 12 to be reset smoothly.

[0021] Before the whole device is used, the operator needs to rotate the pressing handle 7 first. But sometimes doctors may forget to operate the pressing handle 7. In order to discharge the air inside the needle 2 first, in this embodiment, two second gears 10 with the same specifications are symmetrically installed inside the transmission box 6 with the inner rod 12 as the center. Both second gears 10 are rotatably connected to the transmission box 6, and a first gear 11 meshing with the two second gears 10 is fixedly sleeved on the circumferential surface of the inner rod 12. It should be noted that the thickness of the first gear 11 is less than that of the second gear 10, and the difference in their thicknesses is exactly the same as the length of the limiting groove 14. A connecting rod is fixedly connected along the axial direction at the centers of the two second gears 10. The connecting rod extends downward through the outside of the transmission box 6 and is horizontally fixed with a limiting rod 9. A flange 3 is formed at the top edge of the syringe barrel 1, and a limiting hole 4 adapted to the shape of the limiting rod 9 is formed on the flange 3. In the initial state, the transmission box 6 abuts against the upper edge of the flange 3, and the limiting block 23 is located at the bottom of the limiting groove 14. At this time, the limiting rod 9 is located below the flange 3, and the limiting rod 9 and the limiting hole 4 are misaligned at a certain angle. In this state, if the operator directly pulls the piston rod 5, it cannot move outward. The pressing handle 7 must be operated first. When the pressing handle 7 is rotated to drive the inner rod 12 to slide outward, the first gear 11 continuously meshes with and relatively slides with the two second gears 10. While the inner rod 12 rotates, it moves upward. When the limiting block 23 moves to the top of the limiting groove 14, at this time the two limiting rods 9 just rotate to correspond to the limiting holes 4, and the needle 2 is already filled with the liquid medicine. Then the operator pulls the transmission box 6 to drive the piston 8 to slide upward inside the syringe barrel 1, and more liquid medicine enters the syringe barrel 1.

[0022] After the injection is completed, the personnel must manually operate to reset the inner rod 12, otherwise the needle 2 cannot be exhausted first when used next time. Therefore, it is necessary to ensure that the inner rod 12 can be reset after use. Based on this requirement, the present embodiment pre-buried and fixed a motor 16 at the bottom of the inner rod 12, and a telescopic rod 17 is fixedly connected to the output end of the motor 16. A hollow frame 19 is installed at the top center of the sealing block 15, and the end of the telescopic rod 17 is fixedly connected to the center of the hollow frame 19. A timing module can be pre-buried at the bottom of the inner rod 12, and the timing module is used to record the inner rod 1 The time when the bottom of the injection rod 12 is separated from the top of the sealing block 15 is set to a moderate time (usually 3 minutes, which is enough to complete the injection). If the person forgets to manually restore the inner rod 12 after the injection is completed, the timing module will send a signal to the motor 16 after the set time, and the motor 16 will drive the telescopic rod 17 to rotate. However, since the end of the telescopic rod 17 is fixedly connected to the sealing block 15, the sealing block 15 remains fixed and will react to the inner rod 12, so that the inner rod 12 and the motor 16 rotate synchronously, and the inner rod 12 rotates and returns to the initial state.

[0023] In the description of the present invention, the terms "first", "second", "another", and "yet another" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, the features defined as "first" or "second" may explicitly or implicitly include one or more features. In the description of the embodiments of the present invention, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.

[0024] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "connected" and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. In addition, in the description of the present invention, unless otherwise specified, "plurality" means two or more.

[0025] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A targeted treatment device for multiple myeloma, comprising a syringe (1) and a piston rod (5) disposed inside the syringe (1), wherein the bottom of the syringe (1) is detachably connected to a needle (2), and the bottom of the piston rod (5) extends into the inside of the syringe (1) and is integrally connected to a piston (8), characterized in that: The interior of the piston rod (5) is hollow and is equipped with an inner rod (12). A sealing block (15) is provided at the connection point between the piston (8) and the interior of the piston rod (5). A second one-way valve (22) is installed at the center of the sealing block (15). By driving the inner rod (12) to move from the interior of the piston rod (5) toward the exterior thereof, negative pressure is generated inside the needle (2), and the air inside the needle (2) enters the piston rod (5) through the second one-way valve (22).

2. The targeted treatment device for multiple myeloma according to claim 1, characterized in that: The top of the piston rod (5) is connected to a transmission box (6), the inner rod (12) extends upward and penetrates the outside of the transmission box (6) and is fixedly connected to a pressure handle (7), an outer thread (13) is formed on the circumferential surface of the inner rod (12), an inner thread matching the outer thread (13) is formed on the inner wall of the piston rod (5), and the length of the inner thread is greater than that of the outer thread (13).

3. The targeted treatment device for multiple myeloma according to claim 2, characterized in that: A limiting block (23) is also fixedly connected to the circumferential surface of the inner rod (12); the diameter of the limiting block (23) is larger than that of the inner rod (12); and a limiting groove (14) for the limiting block (23) to slide is formed inside the piston rod (5).

4. The targeted treatment device for multiple myeloma according to claim 3, characterized in that: The interior of the sealing block (15) is hollow, and a through hole (20) is provided on a side wall of the sealing block (15) along its radial direction, the through hole (20) being in communication with the interior of the sealing block (15), and an exhaust passage (18) is provided in the interior of the piston (8), one end of the exhaust passage (18) being in communication with the through hole (20), and the other end extending to the exterior of the piston (8) to be in communication with the outside, and a first one-way valve (21) being installed in the interior of the through hole (20).

5. A targeted treatment device for multiple myeloma according to claim 3 or 4, characterized in that: Two second gears (10) of the same specification are symmetrically installed inside the transmission box (6) with the inner rod (12) as the center. The two second gears (10) are both rotatably connected to the transmission box (6). A first gear (11) meshing with the two second gears (10) is fixedly sleeved on the circumferential surface of the inner rod (12). The thickness of the first gear (11) is smaller than that of the second gear (10). A connecting rod is fixedly connected to the center of the two second gears (10) along the axial direction. The connecting rod extends downward and passes through the outside of the transmission box (6). A limiting rod (9) is fixed along the rear side. A flange (3) is formed at the top edge of the syringe (1). A limiting hole (4) matching the shape of the limiting rod (9) is opened on the flange (3). In an initial state, the limiting rod (9) and the limiting hole (4) are offset at a certain angle.

6. The targeted treatment device for multiple myeloma according to claim 5, characterized in that: The difference between the thickness of the first gear (11) and the second gear (10) is consistent with the length of the limiting groove (14).

7. A targeted treatment device for multiple myeloma according to any one of claims 1 to 4, characterized in that: A motor (16) is embedded and fixed at the bottom of the inner rod (12), and a telescopic rod (17) is fixedly connected to the output end of the motor (16). A hollow frame (19) is installed at the center of the top of the sealing block (15), and the end of the telescopic rod (17) is fixedly connected to the center of the hollow frame (19).

8. The targeted treatment device for multiple myeloma according to claim 7, characterized in that: A timing module is embedded in the bottom of the inner rod (12), and the timing module is used to record the time when the bottom of the inner rod (12) separates from the top of the sealing block (15). The motor (16) is controlled by the timing module to drive the inner rod (12) to rotate for resetting.

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