Refrigerated cabinet for preparing medical medicament

Abstract

The invention relates to the technical field of refrigerators, and discloses a medical medicament preparation refrigerated cabinet which comprises a cabinet body, a refrigeration mechanism, a placement seat, a driver, a puncturing device, a first pipeline and a second pipeline, a first containing cavity is formed in the cabinet body, and the refrigeration mechanism is arranged in the cabinet body and connected with the first containing cavity; the placing seat and the driver are mounted in the first accommodating cavity, the placing seat is provided with a clamping groove for fixing a medicament bottle, and the driver is in transmission connection with the puncturing device so as to drive the puncturing device to move up and down to be close to or away from the clamping groove; the puncturing device comprises a needle seat, a needle head and a sealing ring, the needle head penetrates through the needle seat, the sealing ring is installed on the lower side of the needle seat and surrounds the outside of the needle head, and when the needle head punctures downwards, the sealing ring is firstly in sealing fit with the bottle cap; the first pipeline and the second pipeline are arranged in the first containing cavity, a liquid inlet is formed in one end of the first pipeline, and the other end of the first pipeline is connected with the needle. One end of the second pipeline is provided with a liquid outlet, and the other end is connected with the first pipeline.

Description

Technical Field

[0001] The invention relates to the technical field of refrigerators, in particular to a preparation refrigerator for medical medicaments. Background Art

[0002] Botulinum toxin is a neurotoxin produced by Clostridium botulinum that blocks nerve impulses between nerves and muscles and paralyzes and relaxes muscles. Botulinum toxin has been widely used in clinical fields such as neurotherapy, rehabilitation medicine, and cosmetology.

[0003] At present, botulinum toxin is a bottled product of powder preparation, usually stored at low temperature in medical refrigerators, and is required to be prepared and used immediately to ensure the stability of the drug. When used for injection, the whole bottle of botulinum toxin is first diluted and mixed with a certain amount of normal saline, and then the mixture of botulinum toxin and normal saline is quantitatively absorbed and injected into the patient's treatment area. The common specifications of botulinum toxin are 50 units or 100 units, and the general usage is 20 units or less than 10 units. Since botulinum toxin is highly toxic, if the dosage exceeds the safe value or the injection site is improper, it may cause permanent muscle damage and even cause serious medical accidents. Therefore, in clinical practice, it is often the case that botulinum toxin is not used up after dilution. When the bottle is opened, air is mixed into it. Even if it is left for a short time, there is still a risk of reduced toxicity and deterioration and contamination.

[0004] In summary, the unused botulinum toxin after dilution usually needs to be destroyed, resulting in drug waste and high treatment costs. In addition, some medical staff have large errors in dilution dosage, and the shaking operation produces bubbles that easily destroy the botulinum toxin, resulting in poor preparation standardization and safety. Summary of the invention

[0005] The technical problems to be solved by the present invention are: the unused botulinum toxin after dilution needs to be destroyed, resulting in drug waste and high treatment costs; and some medical staff have large errors in dilution dosage, and the shaking operation generates bubbles that easily destroy the botulinum toxin, resulting in poor preparation standardization and safety.

[0006] In order to solve the above technical problems, the present invention provides a technical solution for a medical preparation refrigerator:

[0007] The medical preparation refrigerator comprises a cabinet, a refrigeration mechanism, a placement seat, a driver, a puncture device, a first pipeline and a second pipeline. A first accommodating cavity is provided inside the cabinet, and the refrigeration mechanism is arranged in the cabinet and connected to the first accommodating cavity.

[0008] The placement seat and the driver are both installed in the first accommodating cavity, the placement seat is provided with a slot for fixing the medicine bottle, and the driver is in driving connection with the puncture device to drive the puncture device to move up and down to approach or move away from the slot;

[0009] The puncturing device includes a needle seat, a needle, and a sealing ring. The needle is disposed on the needle seat and penetrates the upper and lower surfaces of the needle seat. The sealing ring is installed on the lower side of the needle seat and surrounds the outside of the needle.

[0010] One end of the first pipeline is provided with a liquid inlet, and the other end of the first pipeline is connected to the needle. One end of the second pipeline is provided with a liquid outlet, and the other end of the second pipeline is connected to the first pipeline.

[0011] A delivery pump and a flow meter are installed on the first pipeline. The delivery pump and the flow meter are arranged between the needle and the second pipeline. The first pipeline and the second pipeline are also provided with a valve assembly for cooperating with the delivery pump to feed liquid in the direction from the first pipeline to the needle and drain liquid in the direction from the needle to the second pipeline.

[0012] Further, a first interface is provided at the end of the first pipeline away from the liquid inlet. The other end of the second pipeline is connected to the first interface. The valve assembly includes a first valve and a second valve. The first valve is installed on the first pipeline between the liquid inlet and the first interface, and the second valve is installed at the second pipeline near the first interface.

[0013] Further, a second interface connected to the needle is also provided at the end of the first pipeline away from the liquid inlet. The first interface is between the first valve and the second interface. The delivery pump is provided between the first interface and the second interface. A flushing pipeline is also connected between the second interface and the second pipeline, and a three-way valve is installed at the intersection of the flushing pipeline and the second interface.

[0014] Further, the preparation refrigerator cabinet further includes a control board. The delivery pump is a micro peristaltic pump. The first valve and the second valve are both solenoid valves. The control board is electrically connected to the delivery pump, the flow meter, the first valve, and the second valve respectively.

[0015] The control board is configured as follows:

[0016] During liquid feeding, control the first valve to open, the second valve to close, and control the delivery pump to rotate forward according to the liquid feeding flow signal detected by the flow meter, so as to feed liquid to the needle through the first pipeline. During liquid draining, control the first valve to close, the second valve to open, and control the delivery pump to rotate backward according to the liquid draining flow signal detected by the flow meter, so as to drain liquid through the second pipeline.

[0017] Further, a pressure sensor is embedded inside the sealing ring. The pressure sensor is used to detect the contact pressure between the sealing ring and the bottle cap. The control board is also electrically connected to the pressure sensor and the driver respectively;

[0018] The control board is further configured to: receive the pressure signal detected by the pressure sensor, and control the driver to stop when the detected pressure reaches the set pressure.

[0019] Further, a pick-and-place opening is provided on one side of the first accommodating cavity. The cabinet is hermetically installed with a first cabinet door corresponding to the pick-and-place opening. When the first cabinet door is closed, the first accommodating cavity forms a sealed cavity; An air pump is also installed inside the cabinet, and the air pump is communicated with the first accommodating cavity.

[0020] Further, a second accommodating cavity is also provided inside the cabinet. The second accommodating cavity is distributed at intervals with the first accommodating cavity. A plurality of trays are installed in the second accommodating cavity. The refrigeration mechanism is connected to the second accommodating cavity. The cabinet is also installed with a second cabinet door corresponding to the second accommodating cavity.

[0021] Further, a long groove is provided on the upper side of the cabinet. The first stop portion and the second stop portion are provided at intervals in the length direction of the long groove. The first stop portion is used for limiting and cooperating with the front end of the barrel of the syringe, and the liquid outlet is arranged opposite to the first stop portion; The second stop portion is used for limiting and cooperating with the tail end of the barrel of the syringe. An avoidance groove is provided on the second stop portion, and the avoidance groove is used for clearance fit with the push rod of the syringe.

[0022] Further, both the first pipeline and the second pipeline are PVC hoses. The inner diameters of the first pipeline and the second pipeline are both less than or equal to 2.5 mm. A straight Luer connector is installed at one end of the second pipeline. The port of the straight Luer connector forms the liquid outlet, and the diameter of the needle is any size between 0.5 mm and 1.2 mm.

[0023] Further, the refrigeration mechanism is a heat pump type refrigeration mechanism, which includes a compressor, a condenser, an expansion valve, an evaporator and a refrigerant circuit. The compressor, the condenser, the expansion valve and the evaporator are arranged in sequence in the refrigerant circuit, and air-cooled channels are connected between the evaporator and the first accommodating cavity and the second accommodating cavity respectively; Alternatively, the refrigeration mechanism is a thermoelectric cooler, and the cold ends of the thermoelectric cooler are respectively communicated with the first accommodating cavity and the second accommodating cavity.

[0024] Compared with the prior art, a refrigerated cabinet for preparing a medical agent of the present invention has the following beneficial effects: The refrigerated cabinet for preparing the medical agent adopts a design form including a cabinet body, a refrigeration mechanism, a placement seat, a driver, a puncturing device, a first pipeline, and a second pipeline. The refrigeration mechanism is arranged in the cabinet body and connected to the first accommodation cavity of the cabinet body. As the cold source of the entire refrigerated cabinet for preparation, the refrigeration mechanism can provide continuous cold quantity to the first accommodation cavity. The placement seat and the driver are both installed in the first accommodation cavity. The driver is in transmission connection with the puncturing device. The medicine bottle can be reliably fixed through the card slot of the placement seat, ensuring the accurate alignment of the position of the medicine bottle and the puncturing device. By driving the puncturing device to move downward close to or upward away from the card slot by the driver, the purpose of automatically puncturing the medicine bottle and pulling out the needle is achieved.

[0025] Among them, the puncturing device includes a needle base, a needle head, and a sealing ring. The needle head is arranged on the needle base and penetrates the upper and lower surfaces of the needle base. The sealing ring is installed on the lower side of the needle base and surrounds the outside of the needle head. That is to say, the bottom of the sealing ring is lower than the bottom of the needle head. During the puncturing process, the puncturing device moves downward. The sealing ring first contacts the bottle cap of the medicine bottle, forming a sealed space in a local area above the bottle cap, reducing the air entering the bottle at the moment of puncturing and opening, and improving the relative cleanliness of the environment inside the bottle. The puncturing device continues to move downward to compress the sealing ring, and the needle head punctures the bottle cap in the sealed space. The sealing ring plays a role of surrounding and protecting the bottle cap break and the needle head, reducing the risk of bottle internal pollution caused by dust and germs in the external environment adhering to the bottle cap break and the needle head.

[0026] Moreover, both the first pipeline and the second pipeline are arranged in the first accommodation cavity. One end of the first pipeline is provided with a liquid inlet, and the other end of the first pipeline is connected to the needle head; one end of the second pipeline is provided with a liquid outlet, and the other end of the second pipeline is connected to the first pipeline; a delivery pump and a flow meter are installed on the first pipeline, and the delivery pump and the flow meter are arranged between the needle head and the second pipeline.

[0027] Before preparation, connect the liquid inlet of the first pipeline to physiological saline, push the syringe to the forefront and connect it to the liquid outlet. After completing the above puncturing process, the delivery pump can be started to feed liquid. When feeding liquid, the physiological saline enters the medicine bottle through the first pipeline and the needle head to accurately pump in a quantitative amount of physiological saline to be diluted and mixed with the medicine in the bottle; after uniform dilution, reverse-start the delivery pump to drain the liquid. The mixed liquid of the medicine and physiological saline reaches the liquid outlet through the needle head, part of the first pipeline, and the second pipeline, and finally accurately inputs the mixed liquid of the medicine and physiological saline into the syringe.

[0028] In addition, the first pipeline and the second pipeline are also provided with valve assemblies, which are used to cooperate with the delivery pump to feed liquid from the first pipeline to the needle direction and drain liquid from the needle to the second pipeline direction. Specifically, before the delivery pump implements liquid feeding, the valve of the first pipeline is opened and the valve of the second pipeline is closed, so that the pipeline between the needle and the liquid inlet forms a connection, ensuring that the delivery pump can only pump the physiological saline into the medicine bottle through the first pipeline.

[0029] Correspondingly, when the delivery pump implements liquid drainage, the valve of the first pipeline is closed and the valve of the second pipeline is opened, so that the pipeline between the needle and the liquid outlet forms a connection, ensuring that the delivery pump can only input the mixed liquid of the medicine and the physiological saline into the syringe through part of the first pipeline and the second pipeline. Moreover, the flowmeter is arranged between the needle and the second pipeline. During this process, the flowmeter can accurately detect the injection volume of the physiological saline and the drainage volume of the mixed liquid of the medicine and the physiological saline, thus ensuring the accuracy and safety of automatic dilution.

[0030] The medical medicine preparation and refrigeration cabinet can complete the closed automatic preparation work of the medicine in the first accommodation cavity. The unused medicine after dilution does not need to be taken out, which can meet the requirements of long-term low-temperature refrigeration, maintain a sealed and relatively clean storage environment, and avoid the problems of medicine waste and high treatment cost caused by destroying the unused medicine. In addition, the dilution and output work is accurately controlled automatically, preventing large errors in the dilution amount used by medical staff, and the generation of bubbles caused by shaking operation is likely to damage the medicine components, thus effectively improving the preparation standardization and safety.

[0031] In the preparation stage of preparation, the packaged medicine products are stored in the second accommodation cavity. Before use, the packaged medicine products are taken out from the second accommodation cavity, first for medical staff and patients to check and verify. After the verification is completed, the package is opened to take out the medicine bottle, then the surface of the bottle cap of the medicine bottle is disinfected, and finally the medicine bottle is reliably placed in the card slot of the placement seat. During preparation, first manually close the first cabinet door to isolate the first accommodation cavity from the external environment. A control signal is sent to the control board through an external computer or a touch panel. The control board first starts the air extraction pump to suck the inside of the first accommodation cavity into a low-pressure environment less than 30 kPa, which can reduce the air and germ content in the first accommodation cavity, and further reduce the risk of the medicine in the bottle being contaminated when punctured. Brief Description of the Drawings

[0032] Figure 1 is a three-dimensional schematic diagram of the medical medicine preparation and refrigeration cabinet in the embodiment of the present invention;

[0033] Figure 2 is a front view schematic diagram of the medical medicine preparation and refrigeration cabinet in the embodiment of the present invention;

[0034] Figure 3 is Figure 2Schematic diagram of the connection of the middle puncturer with the driver, the first pipeline and the second pipeline (partially sectioned at the sealing ring);

[0035] Figure 4 It is a side view schematic diagram of the medical agent preparation and refrigeration cabinet in the long groove in the embodiment of the present invention;

[0036] Figure 5 It is the working principle diagram of the refrigeration mechanism in the embodiment of the present invention;

[0037] In the figure: 1 - cabinet body, 10 - control board, 11 - first accommodating cavity, 12 - second accommodating cavity, 13 - access opening, 14 - first cabinet door, 15 - air extraction pump, 16 - second cabinet door, 17 - tray, 18 - long groove, 181 - first stopping portion, 182 - second stopping portion, 183 - avoidance groove, 2 - refrigeration mechanism, 20 - refrigerant circuit, 21 - compressor, 22 - condenser, 23 - expansion valve, 24 - evaporator, 25 - air-cooling channel, 3 - placement seat, 30 - card slot, 4 - driver, 40 - stepping motor, 41 - lead screw, 42 - slider, 43 - guide rail, 5 - puncturer, 50 - needle seat, 51 - needle tip, 52 - sealing ring, 53 - pressure sensor, 61 - first pipeline, 611 - liquid inlet, 612 - first interface, 613 - second interface, 62 - second pipeline, 621 - liquid outlet, 622 - straight luer connector, 63 - delivery pump, 64 - flowmeter, 65 - valve assembly, 651 - first valve, 652 - second valve, 653 - three-way valve, 66 - flushing pipeline, 7 - medicine bottle, 8 - syringe. Detailed implementation manners

[0038] The following will further describe in detail the specific implementation manners of the present invention in conjunction with the drawings and embodiments. The following embodiments are used to illustrate the present invention, but are not used to limit the scope of the present invention.

[0039] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", etc. in the present invention is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present invention.

[0040] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the quantity of the indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of such features. In the description of the present invention, "a plurality of" means two or more unless otherwise specifically defined.

[0041] In the present invention, unless otherwise clearly specified and defined, terms such as "installed", "connected", "coupled", "fixed", etc. shall be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or integrated; it may be directly connected or indirectly connected through an intermediate medium, and it may be the internal communication of two components or the interaction relationship between two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0042] As Figures 1 to 5 shown, a refrigerated cabinet for preparing a medical agent according to an embodiment of the present invention includes a cabinet body 1, a refrigeration mechanism 2, a placement seat 3, a driver 4, a puncturer 5, a first pipeline 61, and a second pipeline 62. A first accommodation cavity 11 is provided inside the cabinet body 1, and the refrigeration mechanism 2 is disposed in the cabinet body 1 and connected to the first accommodation cavity 11; both the placement seat 3 and the driver 4 are installed in the first accommodation cavity 11. The placement seat 3 is provided with a card slot 30 for fixing a medicine bottle 7, and the driver 4 is in transmission connection with the puncturer 5 to drive the puncturer 5 to move up and down close to or away from the card slot 30.

[0043] The puncturer 5 includes a needle base 50, a needle tip 51, and a sealing ring 52. The needle tip 51 is disposed on the needle base 50 and penetrates the upper and lower surfaces of the needle base 50. The sealing ring 52 is installed on the lower side of the needle base 50 and surrounds the outside of the needle tip 51. When the needle tip 51 pierces downward, the sealing ring 52 is used for sealing cooperation with the cap of the medicine bottle 7; both the first pipeline 61 and the second pipeline 62 are disposed in the first accommodation cavity 11. One end of the first pipeline 61 is provided with a liquid inlet 611, and the other end of the first pipeline 61 is connected to the needle tip 51; one end of the second pipeline 62 is provided with a liquid outlet 621, and the other end of the second pipeline 62 is connected to the first pipeline 61.

[0044] A delivery pump 63 and a flowmeter 64 are installed on the first pipeline 61, and the delivery pump 63 and the flowmeter 64 are arranged between the needle tip 51 and the second pipeline 62; the first pipeline 61 and the second pipeline 62 are further provided with a valve assembly 65 for cooperating with the delivery pump 63 to feed liquid in the direction from the first pipeline 61 to the needle tip 51 and drain liquid in the direction from the needle tip 51 to the second pipeline 62.

[0045] The medical preparation refrigerator adopts the design form of cabinet 1, refrigeration mechanism 2, placement seat 3, driver 4, puncture device 5, first pipeline 61 and second pipeline 62. The refrigeration mechanism 2 is arranged in the cabinet 1 and connected to the first accommodation chamber 11 of the cabinet 1. The refrigeration mechanism 2 serves as the cold source of the entire preparation refrigerator and can provide continuous coldness to the first accommodation chamber 11. The placement seat 3 and the driver 4 are both installed in the first accommodation chamber 11. The driver 4 is connected to the puncture device 5 in a transmission manner. The medicine bottle 7 can be reliably fixed through the card slot 30 of the placement seat 3, ensuring that the position of the medicine bottle 7 is accurately aligned with the puncture device 5. The driver 4 drives the puncture device 5 to move downward toward or upward away from the card slot 30, thereby achieving the purpose of automatically puncturing the medicine bottle 7 and pulling out the needle 51.

[0046] The puncturer 5 includes a needle seat 50, a needle 51 and a sealing ring 52. The needle 51 is arranged on the needle seat 50 and penetrates the upper and lower surfaces of the needle seat 50. The sealing ring 52 is installed on the lower side of the needle seat 50 and surrounds the outside of the needle 51, that is, the bottom of the sealing ring 52 is lower than the bottom of the needle 51. During the puncturing process, the puncturer 5 moves downward, and the sealing ring 52 first contacts the bottle cap of the medicine bottle 7, so that a sealed space is formed in the local area above the bottle cap, reducing the air entering the bottle at the moment of puncturing and opening, and improving the relative cleanliness of the environment inside the bottle; the puncturer 5 continues to move downward to compress the sealing ring 52, and the needle 51 punctures the bottle cap in the sealed space. The sealing ring 52 plays a role of surrounding and protecting the bottle cap rupture and the needle 51, reducing the risk of contamination in the bottle caused by dust and bacteria in the external environment adhering to the bottle cap rupture and the needle 51. The sealing ring 52 used in this embodiment can be a corrugated sealing ring with good elasticity and extrusion sealing performance.

[0047] In addition, the first pipeline 61 and the second pipeline 62 are both arranged in the first accommodating chamber 11, one end of the first pipeline 61 is provided with a liquid inlet 611, and the other end of the first pipeline 61 is connected to the needle 51; one end of the second pipeline 62 is provided with a liquid outlet 621, and the other end of the second pipeline 62 is connected to the first pipeline 61; the first pipeline 61 is installed with a delivery pump 63 and a flow meter 64, and the delivery pump 63 and the flow meter 64 are arranged between the needle 51 and the second pipeline 62.

[0048] Before preparation, connect the liquid inlet 611 of the first pipeline 61 to physiological saline, push the syringe 8 to the front end and connect it to the liquid outlet 621. After completing the above puncturing process, the delivery pump 63 can be started to feed liquid. When feeding liquid, the physiological saline enters the medicine bottle 7 through the first pipeline 61 and the needle 51, so as to accurately and quantitatively pump the physiological saline into the medicine in the bottle for dilution and mixing; after uniform dilution, reverse-start the delivery pump 63 to drain liquid, and the mixed liquid of the medicine and the physiological saline reaches the liquid outlet 621 through the needle 51, part of the first pipeline 61 and the second pipeline 62, and finally the mixed liquid of the medicine and the physiological saline is accurately input into the syringe 8.

[0049] In addition, the first pipeline 61 and the second pipeline 62 are also provided with a valve assembly 65, which is used to cooperate with the delivery pump 63 to feed liquid from the first pipeline 61 to the direction of the needle 51, and to drain liquid from the needle 51 to the direction of the second pipeline 62. Specifically, before the delivery pump 63 feeds liquid, open the valve of the first pipeline 61 and close the valve of the second pipeline 62, so that the pipeline between the needle 51 and the liquid inlet 611 forms a connection, ensuring that the delivery pump 63 can only pump the physiological saline into the medicine bottle 7 through the first pipeline 61.

[0050] Correspondingly, when the delivery pump 63 drains liquid, close the valve of the first pipeline 61 and open the valve of the second pipeline 62, so that the pipeline between the needle 51 and the liquid outlet 621 forms a connection, ensuring that the delivery pump 63 can only input the mixed liquid of the medicine and the physiological saline into the syringe 8 through part of the first pipeline 61 and the second pipeline 62. And, the flowmeter 64 is arranged between the needle 51 and the second pipeline 62. During this process, the flowmeter 64 can accurately detect the injection amount of the physiological saline and the drainage amount of the mixed liquid of the medicine and the physiological saline, thus ensuring the accuracy and safety of automatic dilution.

[0051] The medical medicine preparation refrigerator can complete the closed automatic preparation work of the medicine in the first accommodation cavity 11. The unused medicine after dilution does not need to be taken out, which can meet the requirements of long-term low-temperature refrigeration, maintain a sealed and relatively clean storage environment, and avoid the problems of medicine waste and high treatment cost caused by destroying the unused medicine. In addition, it automatically and accurately controls the dilution and output work, prevents large errors in the dilution amount used by medical staff, and the shaking operation is likely to generate bubbles that easily damage the medicine components, thus effectively improving the preparation standardization and safety.

[0052] In this embodiment, one end of the first pipeline 61 away from the liquid inlet 611 is provided with a first interface 612, and the other end of the second pipeline 62 is connected to the first interface 612. The valve assembly 65 includes a first valve 651 and a second valve 652. The first valve 651 is installed on the first pipeline 61 between the liquid inlet 611 and the first interface 612, and the second valve 652 is installed at a position on the second pipeline 62 close to the first interface 612. The first valve 651 constitutes the valve of the first pipeline 61, and the second valve 652 constitutes the valve of the second pipeline 62. Moreover, the delivery pump 63 and the flowmeter 64 are arranged in the part of the first pipeline 61 between the first interface 612 and the needle 51, and when discharging liquid, the mixed solution of the medicament and the physiological saline is pumped and output through this part of the first pipeline 61.

[0053] The working process of dilution preparation is as follows: when feeding liquid, the first valve 651 is opened and the second valve 652 is closed, and the delivery pump 63 rotates forward to input physiological saline from the liquid inlet 611 to the needle 51; correspondingly, when discharging liquid, the first valve 651 is closed and the second valve 652 is opened, and the delivery pump 63 rotates reversely to output the mixed solution of the medicament and the physiological saline from the needle 51 to the liquid outlet 621. The whole process does not require secondary puncture operation and needle 51 switching, thus achieving the purpose of efficiently completing the dilution and output work with one puncture.

[0054] As a further preferred solution, one end of the first pipeline 61 away from the liquid inlet 611 is further provided with a second interface 613 connected to the needle 51. The first interface 612 is between the first valve 651 and the second interface 613. The delivery pump 63 is arranged between the first interface 612 and the second interface 613. A flushing pipeline 66 is also connected between the second interface 613 and the second pipeline 62, and a three-way valve 653 is installed at the intersection of the flushing pipeline 66 and the second interface 613. That is to say, in the direction from the liquid inlet 611 to the needle 51, the first pipeline 61 is successively arranged with the first interface 612, the flowmeter 64, the delivery pump 63 and the second interface 613, and a flushing pipeline 66 is connected between the second interface 613 and the second pipeline 62.

[0055] It should be noted that whether in the liquid inlet state or the liquid discharge state, the three-way valve 653 is in a conducting state between the delivery pump 63 and the needle 51, and at the same time, the flushing pipeline 66 is in a disconnected state. In other embodiments, in order to simplify the pipeline structure, the design of the second interface 613, the flushing pipeline 66 and the three-way valve 653 can be omitted. After the liquid discharge process is completed and the syringe 8 is removed, the first valve 651 is opened and the second valve 652 is closed, and the three-way valve 653 is adjusted to a conducting state along the direction from the liquid inlet 611 to the flushing pipeline 66. The delivery pump 63 operates forward to output physiological saline from the liquid inlet 611 through the first pipeline 61 and the flushing pipeline 66, and will not enter the medicine bottle 7 through the needle 51, so as to be able to flush and remove residues from the second pipeline 62.

[0056] To improve the automation degree of the whole machine, the refrigerated cabinet for preparation further includes a control board 10. The delivery pump 63 is a micro peristaltic pump, and the first valve 651 and the second valve 652 are both solenoid valves. The control board 10 is electrically connected to the delivery pump 63, the flowmeter 64, the first valve 651 and the second valve 652 respectively. The control board 10 is configured as follows: during liquid inlet, the first valve 651 is controlled to open, the second valve 652 is controlled to close, and the delivery pump 63 is controlled to operate forward according to the liquid inlet flow signal detected by the flowmeter 64, so as to feed liquid to the needle 51 through the first pipeline 61; during liquid discharge, the first valve 651 is controlled to close, the second valve 652 is controlled to open, and the delivery pump 63 is controlled to operate in reverse according to the liquid discharge flow signal detected by the flowmeter 64, so as to discharge liquid through the second pipeline 62. Specifically, the flowmeter 64 adopts a high-precision ultrasonic flow sensor, and its detection accuracy can reach 50 μl or below 50 μl, which can accurately control the liquid inlet volume of physiological saline and the liquid discharge volume of the mixture of medicine and physiological saline.

[0057] Moreover, a pressure sensor 53 is embedded inside the sealing ring 52. The pressure sensor 53 is used to detect the contact pressure between the sealing ring 52 and the bottle cap of the medicine bottle 7. The control board 10 is also electrically connected to the pressure sensor 53 and the driver 4 respectively. The control board 10 is further configured as follows: receive the pressure signal detected by the pressure sensor 53, and control the driver 4 to stop when the detected pressure reaches the set pressure, so as to prevent possible damage caused by excessive pressure.

[0058] Specifically, the driver 4 is an electric screw mechanism, which includes a stepping motor 40, a screw rod 41, a slider 42 and a guide rail 43. The guide rail 43 extends vertically. The slider 42 is slidably assembled with the guide rail 43. The screw rod 41 is arranged in parallel and spaced apart from the guide rail 43. The stepping motor 40 is non-rotatably connected to the screw rod 41 and the screw rod 41 is in threaded cooperation with the slider 42. The stepping motor 40 can be used to accurately drive the slider 42 to move up and down along the guide rail 43. The needle seat 50 of the puncturer 5 is fixedly connected to the slider 42, so as to be able to drive the puncturer 5 to accurately pierce downward and move upward.

[0059] In this embodiment, an access opening 13 is provided on one side of the first accommodation cavity 11, and a first cabinet door 14 is hermetically installed on the cabinet body 1 corresponding to the access opening 13. When the first cabinet door 14 is closed, the first accommodation cavity 11 forms a sealed cavity; an air extraction pump 15 is further installed inside the cabinet body 1, and the air extraction pump 15 is communicated with the first accommodation cavity 11. Moreover, a second accommodation cavity 12 is provided inside the cabinet body 1, the second accommodation cavity 12 is spaced from the first accommodation cavity 11, a plurality of trays 17 are installed in the second accommodation cavity 12, the refrigeration mechanism 2 is connected to the second accommodation cavity 12, and a second cabinet door 16 is further installed on the cabinet body 1 corresponding to the second accommodation cavity 12.

[0060] In the preparation stage of preparation, the packaged pharmaceutical products are stored in the second accommodation cavity 12. The use of the trays 17 can meet the requirement of large-batch stratified storage. Before use, the packaged pharmaceutical products are taken out from the second accommodation cavity 12, first provided for medical staff and patients to check and verify. After the verification is completed, the packaging is opened to take out the medicine bottle 7, and then the surface of the bottle cap of the medicine bottle 7 is disinfected, and finally the medicine bottle 7 is reliably placed in the card slot 30 of the placement seat 3. During preparation, first manually close the first cabinet door 14 to isolate the first accommodation cavity 11 from the external environment, send a control signal to the control board 10 through an external computer or a touch panel, and the control board 10 first starts the air extraction pump 15 to pump the inside of the first accommodation cavity 11 into a low-pressure environment of less than 30 kPa, which can reduce the air and germ content in the first accommodation cavity 11, thereby reducing the risk of the medicine in the bottle being contaminated when punctured. The duration of this decompression process is 10 min to 30 min to prevent the situation of cryogenic freezing due to too large a rate of air pressure drop.

[0061] It should be noted that a long groove 18 is provided on the upper side of the cabinet body 1, as Figure 4 shown, a first stop portion 181 and a second stop portion 182 are provided at intervals in the length direction of the long groove 18. The first stop portion 181 is used for limiting and cooperating with the front end of the barrel of the syringe 8, and the liquid outlet 621 is arranged opposite to the first stop portion 181; the second stop portion 182 is used for limiting and cooperating with the rear end of the barrel of the syringe 8, and an avoidance groove 183 is provided in the second stop portion 182, and the avoidance groove 183 is used for clearance fit with the push rod of the syringe 8. The front and rear limits of the barrel of the syringe 8 are carried out by using the first stop portion 181 and the second stop portion 182, and the avoidance groove 183 allows the push rod of the syringe 8 to slide freely to meet the requirement of volume change during pumping and infusion.

[0062] As a further preferred solution, both the first pipeline 61 and the second pipeline 62 are PVC flexible hoses. The inner diameters of the first pipeline 61, the second pipeline 62, and the flushing pipeline 66 are all less than or equal to 2.5 mm. One end of the second pipeline 62 is equipped with a straight Luer connector 622, and the port of the straight Luer connector 622 constitutes the liquid outlet 621. The diameter of the needle 51 is any size between 0.5 mm and 1.2 mm. The PVC flexible hose has the characteristics of safety, sterility, and good flexibility, and can be applied to the continuous roller pressing of the peristaltic pump. The inner diameters of each pipeline are not greater than 2.5 mm, avoiding the problem of low preparation accuracy caused by excessive liquid loss in the pipeline. Moreover, the port of the straight Luer connector 622 can be screwed and connected to the nipple of the syringe 8, effectively avoiding the problems of sealing failure or loosening at the connection, and achieving the purpose of quick connection and disassembly for use.

[0063] In addition, the refrigeration mechanism 2 is a heat pump type refrigeration mechanism. As Figure 5 shown, it includes a compressor 21, a condenser 22, an expansion valve 23, an evaporator 24, and a refrigerant circuit 20. The compressor 21, the condenser 22, the expansion valve 23, and the evaporator 24 are sequentially arranged in the refrigerant circuit 20, and an air-cooled channel 25 is connected between the evaporator 24 and the first accommodation cavity 11 and the second accommodation cavity 12 respectively. The first accommodation cavity 11 and the second accommodation cavity 12 can be cooled by air through the air-cooled channel 25. To meet different usage requirements, in other embodiments, the refrigeration mechanism can also be designed as a thermoelectric cooler (not shown in the figure). The cold ends of the thermoelectric cooler are respectively communicated with the first accommodation cavity and the second accommodation cavity, and the cold ends of the thermoelectric cooler are used for heat conduction with the two accommodation cavities, which can also play a role in cooling the first accommodation cavity and the second accommodation cavity.

[0064] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the technical principle of the present invention, several improvements and replacements can be made, and these improvements and replacements should also be regarded as the protection scope of the present invention.

Claims

1. A medical preparation refrigerator, characterized in that: The device comprises a cabinet, a refrigeration mechanism, a placement seat, a driver, a puncture device, a first pipeline and a second pipeline, wherein a first accommodating cavity is provided inside the cabinet, and the refrigeration mechanism is arranged in the cabinet and connected to the first accommodating cavity; The placement seat and the driver are both installed in the first accommodating cavity, the placement seat is provided with a slot for fixing the medicine bottle, and the driver is in driving connection with the puncture device to drive the puncture device to move up and down to approach or move away from the slot; The puncture device comprises a needle seat, a needle and a sealing ring, wherein the needle is arranged on the needle seat and penetrates the upper and lower surfaces of the needle seat, and the sealing ring is installed on the lower side of the needle seat and surrounds the outside of the needle; One end of the first pipeline is provided with a liquid inlet, and the other end of the first pipeline is connected to the needle; One end of the second pipeline is provided with a liquid outlet, and the other end of the second pipeline is connected to the first pipeline; The first pipeline is equipped with a delivery pump and a flow meter, and the delivery pump and the flow meter are arranged between the needle and the second pipeline; The first pipeline and the second pipeline are also provided with valve components for cooperating with the delivery pump to allow liquid to flow from the first pipeline to the needle and to discharge liquid from the needle to the second pipeline.

2. The medical preparation refrigerator according to claim 1, characterized in that: A first interface is provided at one end of the first pipeline away from the liquid inlet, and the other end of the second pipeline is connected to the first interface. The valve assembly includes a first valve and a second valve. The first valve is installed on the first pipeline between the liquid inlet and the first interface, and the second valve is installed on the second pipeline close to the first interface.

3. The medical preparation refrigerator according to claim 2, characterized in that: A second interface connected to the needle is also provided at one end of the first pipeline away from the liquid inlet, the first interface is between the first valve and the second interface, the delivery pump is arranged between the first interface and the second interface, a flushing pipeline is also connected between the second interface and the second pipeline, and a three-way valve is installed at the intersection of the flushing pipeline and the second interface.

4. The medical preparation refrigerator according to claim 2 or 3, characterized in that: The preparation refrigerator also includes a control panel, the delivery pump is a micro peristaltic pump, the first valve and the second valve are both solenoid valves, and the control panel is electrically connected to the delivery pump, the flow meter, the first valve, and the second valve respectively; The control board is configured to: When liquid is introduced, the first valve is controlled to be opened and the second valve is controlled to be closed, and the delivery pump is controlled to run in the forward direction according to the liquid introduction flow signal detected by the flow meter, so as to introduce liquid into the needle through the first pipeline; when liquid is discharged, the first valve is controlled to be closed and the second valve is controlled to be opened, and the delivery pump is controlled to run in the reverse direction according to the liquid discharge flow signal detected by the flow meter, so as to discharge liquid through the second pipeline.

5. The medical preparation refrigerator according to claim 4, characterized in that: A pressure sensor is embedded inside the sealing ring, and the pressure sensor is used to detect the contact pressure between the sealing ring and the bottle cap. The control board is also electrically connected to the pressure sensor and the driver respectively; The control board is further configured to receive a pressure signal detected by the pressure sensor, and control the driver to shut down when the detected pressure reaches a set pressure.

6. The medical preparation refrigerator according to claim 1, characterized in that: A loading and unloading opening is provided on one side of the first accommodating cavity, and a first cabinet door is sealedly installed on the cabinet body corresponding to the loading and unloading opening. When the first cabinet door is closed, the first accommodating cavity constitutes a sealed cavity; an air pump is also installed inside the cabinet body, and the air pump is connected to the first accommodating cavity.

7. The medical preparation refrigerator according to claim 6, characterized in that: A second accommodating cavity is also provided inside the cabinet body. The second accommodating cavity is spaced apart from the first accommodating cavity. A plurality of trays are installed in the second accommodating cavity. The refrigeration mechanism is connected to the second accommodating cavity. A second cabinet door is also installed on the cabinet body corresponding to the second accommodating cavity.

8. The medical preparation refrigerator according to claim 1, characterized in that: A long groove is provided on the upper side of the cabinet, and a first stop portion and a second stop portion are provided at intervals in the length direction of the long groove, the first stop portion is used to cooperate with the front end of the barrel of the syringe in a limiting manner, and the liquid outlet is arranged opposite to the first stop portion; the second stop portion is used to cooperate with the rear end of the barrel of the syringe in a limiting manner, and the second stop portion is provided with an avoidance groove, and the avoidance groove is used to cooperate with the clearance of the push rod of the syringe.

9. The medical preparation refrigerator according to claim 1, characterized in that: The first pipeline and the second pipeline are both PVC hoses, the inner diameter of the first pipeline and the inner diameter of the second pipeline are both less than or equal to 2.5 mm, a straight Luer connector is installed at one end of the second pipeline, the port of the straight Luer connector constitutes the liquid outlet, and the diameter of the needle is any size between 0.5 mm and 1.2 mm.

10. The medical preparation refrigerator according to claim 7, characterized in that: The refrigeration mechanism is a heat pump refrigeration mechanism, which includes a compressor, a condenser, an expansion valve, an evaporator and a refrigerant circuit. The compressor, the condenser, the expansion valve and the evaporator are arranged in sequence in the refrigerant circuit, and an air-cooling channel is connected between the evaporator and the first accommodating chamber and the second accommodating chamber respectively; or, the refrigeration mechanism is a semiconductor refrigerator, and the cold end of the semiconductor refrigerator is connected to the first accommodating chamber and the second accommodating chamber respectively.

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