Preparation dispensing method, device and medium

Abstract

The invention relates to the technical field of biomedical treatment, and discloses a preparation subpackaging method and device and a medium. The method comprises the steps that a main pipeline is initialized, and liquid in the main pipeline is emptied into a waste liquid bag; sub-packaging operation is carried out on the sub-packaging containers in sequence; controlling an air filter communicated with one end, far away from the centrifugal container, of the main pipeline, and driving the preparation in the main pipeline to flow back to the centrifugal container by utilizing gas filtered by the air filter; and closing the air filter, and after the preparation in the first branch is injected into the subpackaging container corresponding to the first branch through the gas remaining in the main pipeline, determining that subpackaging is completed. The controller, the centrifugal container, the driving pump, the weighing sensor, the air filter, the control valve, the subpackaging container and the bubble sensor are matched with one another, high-precision preparation is achieved, errors in the preparation subpackaging process are reduced, and the accuracy and precision of preparation subpackaging are improved.

Description

Technical Field

[0001] The present invention relates to the field of biomedical technologies, and particularly to a method, device and medium for preparing and sub-packaging preparations. Background Art

[0002] At present, cell therapy is a key area of focus in the international medical forefront. During the process of cell therapy, the technology of preparing and sub-packaging cell preparations is one of the key steps.

[0003] During the process of cell treatment, it is necessary to sub-package the centrifuged preparations into containers of different specifications. However, even a slight change in the volume of the preparation in the container will seriously affect the accuracy of the preparation. Therefore, the sub-packaging process of the preparation has very high requirements for the accuracy of the preparation. In the existing preparation process, there is an error between the harvested weight and the set target weight, and the error of the existing process preparation reaches ±15 mL, which seriously affects the accuracy of the preparation. Therefore, how to achieve a highly accurate method for preparing and sub-packaging preparations is an urgent problem that those skilled in the art need to solve currently. Summary of the Invention

[0004] Embodiments of the present invention provide a method, device and medium for preparing and sub-packaging preparations to solve the problem of low accuracy in the sub-packaging operation of the existing preparation sub-packaging method.

[0005] A method for preparing and sub-packaging preparations includes:

[0006] Initializing the main pipeline to drain the liquid in the main pipeline into a waste liquid bag;

[0007] Performing a sub-packaging operation on each sub-packaging container in sequence. The sub-packaging operation includes: opening a control valve corresponding to the sub-packaging container, controlling the preparation in the centrifugation container to flow into the sub-packaging container through the control valve, and closing the control valve when the difference between the volume of the preparation flowing into the sub-packaging container and the target volume reaches a preset volume difference; the preset volume difference is determined according to the preset volume of a first branch connected between the control valve and the sub-packaging container;

[0008] Controlling an air filter connected to one end of the main pipeline far from the centrifugation container, and using the gas filtered by the air filter to drive the preparation in the main pipeline to flow back into the centrifugation container;

[0009] Closing the air filter, and injecting the preparation in the first branch into the corresponding sub-packaging container through the gas remaining in the main pipeline to confirm the completion of sub-packaging.

[0010] A preparation sub-packaging device includes a controller, a centrifugation container, a driving pump, a weighing sensor, an air filter, a control valve, a sub-packaging container and a bubble sensor. The preparation sub-packaging device is used to execute the preparation sub-packaging method described above.

[0011] A computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the above-mentioned preparation dispensing method is implemented.

[0012] In the above-mentioned preparation dispensing method, equipment and medium, in the preparation dispensing method of the present invention, the main pipeline is initialized to drain the liquid in the main pipeline into the waste liquid bag; the dispensing operation is sequentially performed on each dispensing container, and the dispensing operation includes: opening the control valve corresponding to the dispensing container, controlling the preparation in the centrifugal container to flow into the dispensing container through the control valve, and closing the control valve when the difference between the preparation volume flowing into the dispensing container and the target volume reaches a preset volume difference; the preset volume difference is determined according to the preset volume of the first branch connected between the control valve and the dispensing container; controlling the air filter connected to one end of the main pipeline away from the centrifugal container, and using the gas filtered by the air filter to drive the preparation in the main pipeline to flow back to the centrifugal container; closing the air filter, and injecting the preparation in the first branch into the corresponding dispensing container through the gas remaining in the main pipeline to confirm the completion of dispensing.

[0013] In the present invention, by initializing the main pipeline to drain the liquid in the main pipeline into the waste liquid bag, the influence of other liquids in the pipeline is avoided, and high-precision preparation dispensing is realized. By using the gas filtered by the air filter to drive the preparation in the main pipeline to flow back to the centrifugal container, precise control of the preparation dispensing is realized, and the accuracy of the dispensed preparation is improved. By injecting the preparation in the first branch into the dispensing container corresponding to the first branch through the gas remaining in the main pipeline, the error in the process of dispensing the preparation is reduced, the accuracy of the preparation volume in the dispensing container is ensured, and thus the precision of the dispensed preparation is improved. Description of the Drawings

[0014] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments of the present invention will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present invention, and those of ordinary skill in the art can also obtain other drawings without creative efforts based on these drawings.

[0015] Figure 1 is a flowchart of the preparation dispensing method in an embodiment of the present invention;

[0016] Figure 2 is a schematic diagram of the preparation dispensing equipment in an embodiment of the present invention. Detailed Embodiments

[0017] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without making creative efforts belong to the scope of protection of the present invention.

[0018] In one embodiment, as Figure 1 and Figure 2 shown, a preparation dispensing method is provided, including the following steps:

[0019] S10: Initialize the main pipeline to drain the liquid in the main pipeline into the waste liquid bag.

[0020] Understandably, the main pipeline refers to the pipeline connecting the centrifuge container 17 to the dispensing container. The centrifuge container 17 is a container for holding the preparation solution, including but not limited to a centrifuge cup, a centrifuge tank, or a centrifuge bottle, etc. The dispensing container ( Figure 2 not shown in the figure, connected to the interface of the control valves 4 / 5 / 6, and each dispensing container corresponds to a control valve) is a container for storing the preparation solution, for example, a product bag, etc.

[0021] Specifically, before starting to dispense the preparation in the centrifuge container 17, during the preparation process, liquids such as cell samples or cleaning liquids are continuously conveyed, so the pipeline is filled with liquid. Therefore, before the preparation dispensing starts, the pipeline needs to be initialized to drain the liquid in the main pipeline into the waste liquid bag. That is, the driving pump 10 on the main pipeline can be started, and the control valves 9, 13, 12, and 11 are opened to drain the liquid in the main pipeline into the waste liquid bag 16; or, another driving pump different from the driving pump on the main pipeline is opened, and the control valves 9, 13, and 11 are opened to drain the liquid in the main pipeline into the waste liquid bag 16 to ensure that the pipeline state remains consistent before and after the preparation operation.

[0022] S20: Perform a dispensing operation on each dispensing container in sequence. The dispensing operation includes: opening the control valve corresponding to the dispensing container, controlling the preparation in the centrifuge container to flow into the dispensing container through the control valve, and closing the control valve when the difference between the preparation volume flowing into the dispensing container and the target volume reaches a preset volume difference; the preset volume difference is determined according to the preset volume of the first branch connected between the control valve and the dispensing container.

[0023] Understandably, the control valve is used to control the opening of the pipeline. The preset volume refers to the pipeline volume of the first branch. The first branch refers to the pipeline between the control valve and the dispensing container. In this embodiment, the first branch uses a silicone tube with an inner diameter of 1.5 mm and an outer diameter of 2.5 mm. By determining the length from the control valve 4 to the dispensing container, the preset volume can be calculated. The preset volume difference is determined according to the preset volume of the first branch connected between the control valve and the dispensing container. The target volume refers to the volume of the preparation in each dispensing container set in advance. For example, the liquid volume is 30 ml, and the two dispensing containers are 10 ml and 20 ml respectively.

[0024] Specifically, after initializing the pipeline, a dispensing operation is performed on each dispensing container. The control valve corresponding to each dispensing container is opened, and the preparation in the centrifuge container 17 is controlled to flow into the dispensing container through the drive pump 10. When the difference between the volume of the preparation flowing into the dispensing container and the target volume reaches the preset volume difference, the control valve is closed.

[0025] In another embodiment, before dispensing the preparation, the preset volume of each first branch is determined, and the target volume of each dispensing container is subtracted by the preset volume of the first branch corresponding to each dispensing container, so as to obtain the volume of the preparation in each dispensing container (that is, the target volume minus the preset volume). In this way, there is no need to calculate the difference in real time. Only the volume of the preparation in each dispensing container needs to be weighed by the weighing sensor. When the volume of the preparation reaches the volume of the preparation in the container, the control valve corresponding to the dispensing container is closed.

[0026] In one embodiment, as Figure 2 shown, first, the control valve 4 of the first dispensing container 41, the control valve 9 and the control valve 14 on the main pipeline are opened. Then, the drive pump 10 is started to inject the preparation in the centrifuge container 17 into the main pipeline, and then into the first dispensing container 41. Among them, the volume of the preparation entering the first dispensing container 41 can be controlled by controlling the rotation speed and rotation time of the drive pump 10. When the volume of the preparation in the first dispensing container 41 is close to the target volume minus the preset volume difference, the preparation is dispensed through the metering tube 20 to achieve precise control of the preparation dispensing. When the difference between the volume of the preparation flowing into the dispensing container and the target volume reaches the preset volume difference, the control valve 4 is closed, and the control valve 5 is opened to dispense the second dispensing container 51 until the dispensing of all dispensing containers ends (that is, the difference between the volume of the preparation in the dispensing container and the target volume reaches the preset volume difference).

[0027] S30: Control the air filter connected to one end of the main pipeline far from the centrifuge container, and use the gas filtered by the air filter to drive the preparation in the main pipeline to flow back into the centrifuge container.

[0028] Understandably, the air filter 19 refers to a device for removing solid particles from the air.

[0029] Specifically, after all the dispensing containers have completed the dispensing of the preparation, that is, after closing the control valve corresponding to the last dispensing container, the air filter 19 at the end of the main pipeline far from the centrifugal container is controlled to be connected, that is, the control valve 7 corresponding to the air filter 19 is opened, and the driving pump 10 is started and reversed to start injecting gas into the main pipeline, and the injected gas is filtered by the air filter 19 to ensure that no impurities are injected, ensuring the quality of the preparation. Finally, the preparation in the main pipeline is driven back to the centrifugal container 17 by the gas filtered by the air filter 19. Among them, by controlling the reverse rotation time of the driving pump 10, it is ensured that all the preparation in the main pipeline flows back to the centrifugal container.

[0030] In another embodiment, a blowing device (not shown in the figure) is connected to the interface corresponding to the air filter 19. After closing the control valve corresponding to the last dispensing container and the driving pump 10, gas is blown into the main pipeline through the blowing device, and the blown gas is filtered by the air filter 19. Then, the preparation in the main pipeline is driven back to the centrifugal container 17 by the filtered gas.

[0031] In one embodiment, in step S30, a bubble sensor and a driving pump are provided on the main pipeline; that is, the preparation in the main pipeline is driven back to the centrifugal container by the gas filtered by the air filter, and further includes:

[0032] S301, start the driving pump to control the gas filtered by the air filter to flow into the main pipeline through the driving pump, and at the same time monitor whether there is gas flowing through by the bubble sensor.

[0033] S302, when the bubble sensor monitors that there is gas flowing through the main pipeline, record the current time, and after a second preset time period, control the interruption of the connection between the main pipeline and the air filter, and confirm that the preparation in the main pipeline has completely flowed back to the centrifugal container.

[0034] Understandably, the driving pump in this embodiment refers to a peristaltic pump. The bubble sensor is a sensor used to detect and measure whether there are bubbles in the liquid. A bubble sensor and a driving pump are provided on the main pipeline. The current time refers to the time when the gas flows through the bubble sensor.

[0035] Specifically, after controlling the air filter 19 at the end of the main pipeline away from the centrifugal container to be turned on, start the drive pump 10 and reverse the rotation direction of the drive pump 10 during the preparation of the preparation for sub-packaging, so as to inject the gas filtered by the air filter 19 into the main pipeline. At the same time, monitor the gas in the main pipeline through the bubble sensor 18 provided on the main pipeline to determine whether there is gas flowing through the main pipeline. Further, when the bubble sensor 18 monitors that there is gas flowing through the main pipeline, record the current time when the gas flows through the bubble sensor 18, and after controlling the injection of gas for a second preset duration, turn off the drive pump 10 and the control valve 7 corresponding to the air filter 19, and control the interruption of the connection between the main pipeline and the air filter 19, so that the preparation in the main pipeline completely flows back into the centrifugal container 17. Among them, different second preset durations can be set by setting the bubble sensor 18 at different positions on the main pipeline. That is, in this embodiment, by injecting gas, the preparation in the main pipeline is made to flow back, thus ensuring the accuracy rate of the preparation sub-packaging. By monitoring the time of the injected gas through the bubble sensor, the preparation in the main pipeline is completely injected into the centrifugal container, reducing the error in the process of sub-packaging the preparation, and further improving the accuracy of sub-packaging the preparation.

[0036] S40: Close the air filter, and inject the preparation in the first branch into the corresponding sub-packaging container through the gas remaining in the main pipeline to confirm the completion of sub-packaging.

[0037] Specifically, after reaching the preset blowing time, that is, after determining that the preparation in the main pipeline has completely flowed back into the centrifugal container, close the air filter and the corresponding control valve. After injecting the preparation in the first branch into the sub-packaging container corresponding to the first branch through the gas remaining in the main pipeline, that is, injecting the preparation in the first branch into the sub-packaging container corresponding to each first branch through the gas in the main pipeline, after the preparations in all the first branches have been injected into the corresponding sub-packaging containers, confirm the completion of sub-packaging.

[0038] In one embodiment, after closing the control valve 7 corresponding to the air filter 19, open the control valve 4, and inject the preparation in the first branch between the control valve 4 and the first sub-packaging container 41 into the first sub-packaging container 41 through the gas remaining in the main pipeline. Then, close the control valve 4, open the control valve 5, and inject the preparation in the first branch between the control valve 5 and the second sub-packaging container 51 into the second sub-packaging container 51 through the gas remaining in the main pipeline. Next, close the control valve 5, open the control valve 6, and inject the preparation in the first branch between the control valve 6 and the second sub-packaging container 61 into the second sub-packaging container 61 through the gas remaining in the main pipeline, until the preparations in all the first branches have been respectively injected into the corresponding sub-packaging containers, and then confirm the completion of sub-packaging.

[0039] In the preparation dispensing method of the present invention, by initializing the main pipeline to empty the liquid in the main pipeline into the waste liquid bag, the influence of other liquids in the pipeline is avoided, and high-precision preparation dispensing is achieved. By using the gas filtered by the air filter to drive the preparation in the main pipeline to flow back into the centrifugal container, precise control of the preparation dispensing is realized, and the accuracy of the dispensed preparation is improved. By using the gas remaining in the main pipeline to inject the preparation in the first branch into the dispensing container corresponding to the first branch, the error in the process of dispensing the preparation is reduced, the accuracy of the preparation volume in the dispensing container is ensured, and further the precision of the dispensed preparation is improved.

[0040] In one embodiment, in step S10, that is, initializing the main pipeline to empty the liquid in the main pipeline into the waste liquid bag, includes:

[0041] S101, performing a pre-filling process on the second branch, where the second branch refers to other branches that communicate with the main pipeline and exclude the first branch.

[0042] S102, starting the driving pump installed on the main pipeline to control the liquid in the main pipeline to be emptied into the waste liquid bag through the driving pump.

[0043] It can be understood that the second branch refers to other branches that communicate with the main pipeline and exclude the first branch. Or, the second branch refers to the pipelines between the control valves 1, 2, and 3 and the main pipeline.

[0044] Specifically, when initializing the main pipeline, first perform a pre-filling process on the second branch, that is, the second branch can be pre-filled with a cleaning liquid. That is, close the control valves 14 and 15, open the control valve 2, and pre-fill the second branch that communicates with the main pipeline and excludes the first branch with the cleaning liquid. Then, by opening the control valves 13, 12, and 11, and starting the driving pump 10 installed on the main pipeline, or opening the control valves 13 and 11, and starting the second driving pump outside the main pipeline, all the liquid in the second branch is discharged into the waste liquid bag 16. That is, in this embodiment, the emptying of the liquid in the second branch is realized, thereby ensuring precise control of the volume during the dispensing of the preparation and improving the precision of the dispensed preparation.

[0045] In one embodiment, in step S20, one weighing sensor is associated with one dispensing container; that is, confirming that the difference between the preparation volume flowing into the dispensing container and the target volume reaches a preset volume difference, includes:

[0046] S201, obtaining the preparation volume flowing into the dispensing container in real time through the weighing sensor.

[0047] S202. Determine the difference between the volume of the preparation and the target volume.

[0048] S203. Obtain a preset volume difference. When the difference is less than or equal to the preset volume difference, confirm that the difference reaches the preset volume difference.

[0049] Understandably, the weighing sensor is a sensor used to measure the preparation in the dispensing container. The preset volume difference refers to the difference between the volume of the preparation in the dispensing container set in advance and the target volume.

[0050] Specifically, after opening the control valve corresponding to the dispensing container and controlling the preparation in the centrifuge container to flow into the dispensing container through the control valve, the volume of the preparation flowing into the dispensing container is obtained in real time through the weighing sensor (not shown in Figure 2 ), that is, the weight change of the dispensing container during the preparation dispensing process is collected through the weighing sensor, so as to obtain the volume of the preparation flowing into the dispensing container in real time. And based on the volume of the preparation obtained in real time, calculate the difference between the volume of the preparation obtained in real time and the target volume of each dispensing container. Compare the obtained preset volume difference with the difference. When the difference is greater than the preset volume difference, continue to flow the preparation into the dispensing container. When the difference is less than or equal to the preset volume difference, confirm that the difference reaches the preset volume difference. Among them, preferably when the difference is equal to the preset volume difference, confirm that the difference reaches the preset volume difference.

[0051] In another embodiment, by calculating the volume of the preparation that should be contained in each dispensing container except for the preset volume in the first branch, that is, subtracting the preset volume from the target volume of each dispensing container. Then, it is only necessary to obtain in real time through the weighing sensor whether the volume of the preparation reaches the difference between the target volume minus the preset volume, so as to determine whether to stop injecting the preparation into the dispensing container.

[0052] That is, in this embodiment, the volume of the preparation in the dispensing container is measured in real time through the weighing sensor, realizing precise control of the volume of the preparation in the dispensing container. By comparing with the preset volume difference, it is realized that the volume of the preparation in the dispensing container plus the residual volume in the first branch is equal to the target volume, improving the accuracy of preparation dispensing.

[0053] In one embodiment, in step S30, that is, controlling to connect the air filter at the end of the main pipeline far from the centrifuge container, includes:

[0054] S303. After determining that all the dispensing containers have completed the dispensing operation, control to connect the air filter at the end of the main pipeline far from the centrifuge container.

[0055] Specifically, after determining that all dispensing containers have completed the dispensing operation, that is, when the difference between the preparation volume and the target volume in the last dispensing container measured by the weighing sensor reaches the preset volume difference, it is determined that all dispensing containers have completed the dispensing operation. Then, control is used to turn on the air filter at the end of the main pipeline far from the centrifugal container, that is, open the control valve corresponding to the air filter, and start the drive pump and reverse it to inject gas into the main pipeline.

[0056] Injecting the preparation in the first branch into the corresponding dispensing container through the gas remaining in the main pipeline to confirm the completion of dispensing includes:

[0057] S401, injecting the preparations in each of the first branches into the corresponding dispensing containers through the gas remaining in the main pipeline.

[0058] S402, determining the target container from all the dispensing containers, controlling the remaining preparation in the centrifugal container to flow into the target container, and confirming the completion of dispensing.

[0059] Understandably, the target container refers to the dispensing container for flowing in the residual preparation. For example, the first dispensing container or the last dispensing container.

[0060] Specifically, after all the preparations in the main pipeline are injected into the centrifugal container 17 by the gas injected by reversing the drive pump 10, the preparations in each first branch are respectively injected into the corresponding dispensing containers through the gas remaining in the main pipeline. That is, open the control valve 4 corresponding to the first dispensing container 41, and then inject the preparation in the first branch corresponding to the control valve 4 into the first dispensing container 41. Then, the preparations in each first branch are respectively injected into the corresponding dispensing containers. After that, determine the target container from all the dispensing containers. That is, any one of them can be randomly selected, or the dispensing container with the largest error between the preparation volume and the target volume measured by the weighing sensor in each dispensing container can be determined as the target container. Next, control the remaining preparation in the centrifugal container 17 to flow into the target container and confirm the completion of dispensing. That is, open the control valve 14, the control valve 9, and the control valve corresponding to the target container, and start the drive pump 10 to pump the remaining preparation in the centrifugal container 17 and the remaining preparation in the main pipeline returned by the gas together into the target container. In this way, it can be determined that the preparation in the centrifugal container 17 has been dispensed. That is, in this embodiment, by determining the target container from all the dispensing containers, the accurate control of the preparation volume in other dispensing containers except the target container is realized. Controlling the remaining preparation in the centrifugal container to flow into the target container avoids the waste of the preparation in the centrifugal container.

[0061] In the first embodiment, in step S401, injecting the preparations in each of the first branches into the dispensing containers corresponding to the first branches respectively by the gas remaining in the main pipeline includes:

[0062] S4011. Controlling the control valves corresponding to the other dispensing containers except the target container to be opened in sequence all at once, and injecting the preparations in each of the first branches into the other dispensing containers corresponding to the opened control valves respectively by the gas remaining in the main pipeline.

[0063] Specifically, after disconnecting the injection device from the main pipeline, controlling the control valves corresponding to the other dispensing containers except the target container to be opened in sequence all at once, and injecting the preparations in each of the first branches into the other dispensing containers corresponding to the opened control valves respectively by the gas remaining in the main pipeline. That is, first determine the position of the target container. When the target container is any one of the dispensing containers, that is, opening the control valve 4 corresponding to the first dispensing container 41, and injecting the preparation in the first branch corresponding to the first dispensing container 41 into the first dispensing container 41 by the gas remaining in the main pipeline; then closing the control valve 4 corresponding to the first dispensing container 41, skipping the control valve corresponding to the target container, opening the control valve corresponding to the next dispensing container, and injecting the preparation in the first branch corresponding to this dispensing container into this dispensing container by the gas remaining in the main pipeline, and closing the control valve corresponding to this dispensing container. In this way, the preparations in all the first branches are injected into the corresponding dispensing containers except the target container respectively. That is, in this embodiment, the preparation in each first branch except the target container is injected into the corresponding dispensing container, and the volume of the preparation in each dispensing container except the target container is made the target volume, thereby improving the accuracy and precision of the preparation dispensing.

[0064] In the second embodiment, in step S401, injecting the preparations in each of the first branches into the dispensing containers corresponding to the first branches respectively by the gas remaining in the main pipeline includes:

[0065] S4012. Controlling the control valves corresponding to all the dispensing containers to be opened in sequence all at once, and injecting the preparations in each of the first branches into the dispensing containers corresponding to the first branches respectively by the gas remaining in the main pipeline.

[0066] Specifically, after disconnecting the injection device from the main pipeline, control all the control valves corresponding to the dispensing containers to be opened in sequence. The preparations in each first branch are respectively injected into the dispensing containers corresponding to each first branch through the gas remaining in the main pipeline. That is, first open the control valve 4 corresponding to the first dispensing container 41, and inject the preparation in the first branch corresponding to the first dispensing container 1 into the first dispensing container 41 through the gas remaining in the main pipeline; then close the control valve 4 corresponding to the first dispensing container 41, and open the control valve 5 corresponding to the second dispensing container 51. Inject the preparation in the first branch corresponding to the second dispensing container 51 into the second dispensing container 51 through the gas remaining in the main pipeline, and close the control valve 5 corresponding to the second dispensing container, and open the control valve 6 corresponding to the third dispensing container 61. Inject the preparation in the first branch corresponding to the third dispensing container 61 into the third dispensing container 61 through the gas remaining in the main pipeline, and close the control valve 6 corresponding to the second dispensing container. In this way, the preparations in all the first branches are respectively injected into the corresponding dispensing containers. That is, in this embodiment, the preparation in each first branch is injected into the corresponding dispensing container, and the volume of the preparation in each dispensing container is made the target volume, thereby improving the accuracy and precision of the preparation dispensing.

[0067] In the third embodiment, in the step S401, injecting the preparations in each of the first branches into the dispensing containers corresponding to each of the first branches through the gas remaining in the main pipeline includes:

[0068] S4013, after opening the control valve corresponding to the dispensing container, start recording the real-time discharge duration of the gas entering the first branch. When the real-time discharge duration reaches the first preset duration, confirm that the preparation in the first branch has been completely injected into the corresponding dispensing container.

[0069] Understandably, the real-time discharge duration refers to the time when the gas enters the first branch. The first preset duration refers to the total time for the gas to enter the first branch set in advance.

[0070] Specifically, after disconnecting the injection device from the main pipeline, the control valves corresponding to each dispensing container are opened in sequence. First, the control valve 4 corresponding to the first dispensing container 41 is opened, and the gas remaining in the main pipeline enters the first branch corresponding to the first dispensing container 41, so as to inject the preparation in the first branch into the first dispensing container 41. Among them, by recording the real-time discharge duration of the gas entering the first branch, when the real-time discharge duration reaches the first preset duration, it is confirmed that the preparation in the first branch has been completely injected into the corresponding first dispensing container 41. The control valve 4 corresponding to the first dispensing container 1 is closed, and the control valve 5 corresponding to the second dispensing container 51 is opened. The gas remaining in the main pipeline enters the first branch corresponding to the second dispensing container 51, so as to inject the preparation in the first branch into the second dispensing container 51. Among them, by recording the real-time discharge duration of the gas entering the first branch, when the real-time discharge duration reaches the first preset duration, it is confirmed that the preparation in the first branch has been completely injected into the corresponding second dispensing container 51. This is done until all the preparations in the first branches are injected into the corresponding dispensing containers through the gas. That is to say, in this embodiment, when the control valve is opened to inject the preparation in the first branch into the dispensing container through the gas, the volume of the preparation in the dispensing container reaches the target volume, ensuring the accuracy of the preparation volume and improving the precision of the preparation dispensing.

[0071] It should be understood that the magnitudes of the sequence numbers of the steps in the above embodiments do not mean the order of execution. The order of execution of each process should be determined according to its function and internal logic, and should not constitute any limitation to the implementation process of the embodiments of the present invention.

[0072] A preparation dispensing device includes a controller, a centrifugal container, a driving pump, a weighing sensor, an air filter, a control valve, a dispensing container, and a bubble sensor. The preparation dispensing device is used to execute a preparation dispensing method.

[0073] Specific limitations on the preparation and dispensing equipment, the controller, and its various units and modules can be referred to the limitations on the preparation and dispensing method in the above text, and will not be elaborated here. Each module in the above controller can be implemented in whole or in part by software, hardware, and their combinations. Understandably, the controller includes a processor, a memory, a network interface, and a database connected through a device bus. Each module of the controller can be embedded in or independent of the processor in the form of hardware, or stored in the memory in the form of software, so that the processor can call and execute the operations corresponding to each of the above modules. Among them, the processor is used to provide computing and control capabilities. The memory includes a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating device, a computer program, and a database. The internal memory provides an environment for the operation of the operating device and the computer program in the non-volatile storage medium. The database is used to store the data used in the preparation and dispensing method in the above embodiments. The network interface is used to communicate with an external terminal through a network connection. When the computer program is executed by the processor, it implements a preparation and dispensing method.

[0074] In one embodiment, a computer-readable storage medium is provided, and the computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the above preparation and dispensing method is implemented.

[0075] Those of ordinary skill in the art can understand that all or part of the processes in the methods of the above embodiments can be completed by instructing relevant hardware through a computer program. The computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the embodiments of the above methods. Among them, any reference to the memory, storage, database, or other media used in the various embodiments provided in the present application can include non-volatile and / or volatile memories. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory can include random access memory (RAM) or an external cache memory. By way of illustration and not limitation, RAM is available in many forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

[0076] Those skilled in the art can clearly understand that, for the convenience and conciseness of description, only the above-mentioned division of each functional unit and module is used as an example. In actual applications, the above functions can be assigned to different functional units and modules according to needs, that is, the internal structure of the device is divided into different functional units or modules to complete all or part of the functions described above.

[0077] The above-described embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention, and should all be included within the protection scope of the present invention.

Claims

1. A preparation sub-packaging method, characterized in that, Including: Initializing the main pipeline to drain the liquid in the main pipeline into a waste liquid bag; Performing a dispensing operation on each dispensing container in sequence, the dispensing operation including: opening a control valve corresponding to the dispensing container, controlling the preparation in the centrifugal container to flow into the dispensing container through the control valve, and closing the control valve when the difference between the preparation volume flowing into the dispensing container and the target volume reaches a preset volume difference; the preset volume difference is determined according to the preset volume of a first branch connected between the control valve and the dispensing container; Controlling an air filter connected to one end of the main pipeline far from the centrifugal container, and driving the preparation in the main pipeline to flow back into the centrifugal container by using the gas filtered by the air filter; Closing the air filter, and injecting the preparation in the first branch into the corresponding dispensing container through the gas remaining in the main pipeline to confirm the completion of dispensing.

2. The preparation dispensing method according to claim 1, wherein The initializing the main pipeline to drain the liquid in the main pipeline into a waste liquid bag includes: Performing a pre-filling process on a second branch, where the second branch refers to other branches connected to the main pipeline except the first branch; Starting a driving pump installed on the main pipeline to control the liquid in the main pipeline to be drained into a waste liquid bag through the driving pump.

3. The preparation dispensing method according to claim 1, wherein The controlling the air filter connected to one end of the main pipeline far from the centrifugal container includes: After determining that all the dispensing containers have completed the dispensing operation, controlling the air filter connected to one end of the main pipeline far from the centrifugal container; The injecting the preparation in the first branch into the corresponding dispensing container through the gas remaining in the main pipeline to confirm the completion of dispensing includes: Injecting the preparation in each first branch into the corresponding dispensing container through the gas remaining in the main pipeline respectively; Determining a target container from all the dispensing containers, controlling the remaining preparation in the centrifugal container to flow into the target container, and confirming the completion of dispensing.

4. The preparation sub-packaging method according to claim 3, wherein The injecting the preparation in each first branch into the corresponding dispensing container through the gas remaining in the main pipeline respectively includes: Controlling the control valves corresponding to other dispensing containers except the target container to be opened in sequence, and injecting the preparation in each first branch into the other corresponding dispensing containers through the gas remaining in the main pipeline.

5. The preparation sub-packaging method according to claim 3, characterized in that, The injecting the preparation in each first branch into the corresponding dispensing container through the gas remaining in the main pipeline respectively includes: Controlling the control valves corresponding to all the dispensing containers to be opened in sequence, and injecting the preparation in each first branch into the corresponding dispensing container through the gas remaining in the main pipeline respectively.

6. The preparation sub-packaging method according to claim 3, characterized in that, The injecting the preparation in each first branch into the corresponding dispensing container through the gas remaining in the main pipeline respectively includes: After opening the control valve corresponding to the dispensing container, start recording the real-time discharge duration of the gas entering the first branch. When the real-time discharge duration reaches the first preset duration, confirm that the preparation in the first branch has been completely injected into the corresponding dispensing container.

7. The preparation dispensing method according to claim 1, wherein One dispensing container is associated with one weighing sensor; The step of confirming that the difference between the preparation volume of the preparation flowing into the dispensing container and the target volume reaches a preset volume difference further includes: Obtain the preparation volume of the preparation flowing into the dispensing container in real time through the weighing sensor; Determine the difference between the preparation volume and the target volume; Obtain the preset volume difference. When the difference is less than or equal to the preset volume difference, confirm that the difference reaches the preset volume difference.

8. The preparation sub-packaging method according to claim 1, wherein A bubble sensor and a drive pump are provided on the main pipeline; The step of using the gas filtered by the air filter to drive the preparation in the main pipeline to flow back to the centrifuge container further includes: Start the drive pump to control the gas filtered by the air filter to flow into the main pipeline through the drive pump, and at the same time monitor whether there is gas flowing through by the bubble sensor; When the bubble sensor detects that there is gas flowing through the main pipeline, record the current time, and after a second preset duration, control the interruption of the connection between the main pipeline and the air filter, and confirm that the preparation in the main pipeline has completely flowed back to the centrifuge container.

9. A preparation dispensing device, characterized in that, It includes a controller, a centrifuge container, a drive pump, a weighing sensor, an air filter, a control valve, a dispensing container and a bubble sensor. The preparation dispensing device is used to execute the preparation dispensing method according to any one of claims 1 to 8.

10. A computer-readable storage medium storing a computer program, characterized in that, When the computer program is executed by a processor, it implements the preparation dispensing method according to any one of claims 1 to 8.

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