Sampling equipment for quality detection of lenalidomide

Abstract

The invention discloses sampling equipment for lenalidomide quality detection, and relates to the technical field of powder sampling, the sampling equipment comprises an isolation cavity, an outward opening window is arranged in the isolation cavity, a self-adaptive killing mechanism is arranged in the isolation cavity, the outward opening window is arranged on the front surface of the isolation cavity, and the self-adaptive killing mechanism is arranged in the isolation cavity. The self-adaptive killing mechanism comprises a cylindrical cover, a group of external connection seats are fixedly mounted on the outer surface wall of the cylindrical cover, an ultraviolet lamp panel is fixedly connected to the interior of each external connection seat, an annular frame is fixedly mounted at the bottom of the cylindrical cover, the mechanism adopts an operation mode of chemical labeling and physical sterilization, an independent detention space is constructed, and the self-adaptive killing mechanism is arranged in the annular frame. According to the device, the cavity is sealed, isolation from outside air is completed, microorganisms and bacteria contained in the cavity are fully and cleanly treated in a treatment mode of combining fluorescence labeling and ultraviolet killing, the time of a sterile state in the cavity is further prolonged by adopting a physical blocking mode, and it is guaranteed that medicine is prevented from being polluted by the outside air when transferred.

Description

Technical Field

[0001] The present invention relates to the technical field of powder sampling, and specifically to a sampling device for the quality inspection of lenalidomide. Background Technique

[0002] As an important immunomodulatory drug, lenalidomide plays an important role in the treatment of various hematological malignancies such as multiple myeloma, myelodysplastic syndrome, and mantle cell lymphoma.

[0003] To prevent and eliminate potential risks of the drug and ensure the safety of patients' medication, before the preparation of lenalidomide capsules, various quality inspections need to be carried out first to ensure the safety, effectiveness, and consistency of the drug. Conventional lenalidomide is mainly in powder form, so when conducting drug inspections, a suitable sampling device is required to complete the collection and transfer of samples.

[0004] However, the existing sampling devices for the quality inspection of lenalidomide have the following deficiencies:

[0005] Lenalidomide is extremely vulnerable to microbial contamination, resulting in changes in chemical composition, physical properties, and biological activity, etc. After the drug powder is sampled by relevant equipment and during the transfer process, the drug needs to stay in the equipment for a period of time, and during this period, the drug is easily contaminated by microorganisms in the air. However, due to the limitations of its own structure, traditional equipment cannot independently construct a sterile environment and can only rely on the site environment to measure the quality of the transferred samples. This not only causes high usage limitations but also cannot ensure that the drug after transfer is exactly the same as the drug before transfer, thus seriously affecting the subsequent test results.

[0006] Therefore, we propose a sampling device for the quality inspection of lenalidomide to solve the problems raised above. Summary of the Invention

[0007] The purpose of the present invention is to provide a sampling device for the quality inspection of lenalidomide. The provided adaptive sterilization mechanism can, during the sterilization process, first have the detection component completely obtain the distribution of microorganisms on the inner wall of the cavity. According to the density of each region, by controlling the intensity and treatment duration of the sterilization component, the overall sterilization of the cavity is completed, ensuring that after the action is executed, the cavity is briefly in a pollution-free state, and when the relevant components are reset, the top of the cavity can also be blocked, greatly reducing the probability of external microorganisms entering the cavity, so as to solve the problems raised in the above background technique.

[0008] To achieve the above purpose, the present invention provides the following technical solution: A sampling device for the quality inspection of lenalidomide, including an isolation cavity, and an externally opened viewing window is provided inside the isolation cavity;

[0009] An adaptive sterilization mechanism is provided inside the isolation cavity, and an externally opened viewing window is provided on the front surface of the isolation cavity;

[0010] The adaptive killing mechanism includes a cylindrical cover. A set of external connectors are fixedly installed on the outer surface wall of the cylindrical cover. An ultraviolet lamp board is fixedly connected inside each external connector. A circular frame is fixedly installed at the bottom of the cylindrical cover. A metal protective cover is fixedly installed between the outer surface walls of the circular frame. An ATP luminescence test component is arranged inside the metal protective cover. A first horizontal plate is fixedly installed at the bottom of the circular frame. A circular liquid storage tank and a micro pump body are respectively fixedly installed at the bottom of the first horizontal plate. A circular transition box is fixedly installed on the inner surface wall of the metal protective cover. The output end of the micro pump body is fixedly communicated with a square connector. A set of U-shaped frames are equidistantly installed on the outer surface wall of the circular transition box. A set of atomizing nozzles are fixedly installed inside each U-shaped frame. A top frame is fixedly installed at the top of the cylindrical cover. A load-bearing support plate and a lithium battery box are respectively fixedly installed at the top of the top frame. An electric control component is fixedly installed on the top of the load-bearing support plate. The output end of the lithium battery box is fixedly connected with a set of wires. The output ends of a set of wires are all connected to the wiring terminals of the electric control component.

[0011] Preferably, the input end of the micro pump body is fixedly communicated with a set of first shunt pipes. The liquid inlet ends of a set of first shunt pipes all penetrate through the outer surface wall of the circular liquid storage tank and are communicated with the inside of the circular liquid storage tank. The outer surface wall of the square connector is fixedly communicated with four groups of second shunt pipes. The liquid discharge ends of each group of second shunt pipes all penetrate through the outer surface wall of the circular transition box and are communicated with the inside of the circular transition box. The liquid inlet end of each group of atomizing nozzles penetrates through the outer surface wall of the circular transition box and is communicated with the inside of the circular transition box.

[0012] Preferably, a shut-off valve body is fixedly communicated with the outer surface wall of the circular liquid storage tank. The liquid inlet end of the shut-off valve body is fixedly communicated with a liquid inlet connector.

[0013] Preferably, a first limiting component is fixedly installed on one side of the outer wall of the isolation cavity. A first associated frame is fixedly installed inside the first limiting component. Two splicing plates are fixedly installed at the top of the cylindrical cover. The first associated frame is connected to one of the splicing plates.

[0014] Preferably, the linkage and cooperation mechanism includes two sliding sleeves. Both sliding sleeves are fixedly installed on the front surface of the isolation cavity. A row of teeth is movably arranged inside each sliding sleeve.

[0015] Preferably, a second horizontal plate is fixedly installed between the front surfaces of the two sliding sleeves. A speed reducer is fixedly installed on the front surface of the second horizontal plate. The input end of the speed reducer is fixedly connected with a first driving motor. A driving gear is fixedly sleeved on the shaft end of the speed reducer. The driving gear is meshed with the two rows of teeth.

[0016] Preferably, a chute is provided inside each of the row of teeth, an electric push assembly is fixedly installed on the outer surface wall of each sliding sleeve, a connecting plate is fixedly sleeved on the shaft end of each electric push assembly, T-shaped sliding bars are fixedly installed on the opposite sides of the two connecting plates, and each T-shaped sliding bar is respectively movably arranged inside a corresponding chute.

[0017] Preferably, a second connecting frame is fixedly installed on the top of one of the row of teeth, an extension plate is fixedly installed on the outer surface wall of one of the splicing plates, a first movable member is provided at one end of the extension plate, the second connecting frame is connected to the first movable member, a third connecting frame is fixedly installed on the bottom of one of the row of teeth, a second movable member is provided at the bottom of the third connecting frame, a U-shaped joint is provided on one side of the outer wall of the second movable member, a cross bar is movably inserted between the two inner sides of the inner wall of the U-shaped joint, a second driving motor is fixedly installed on one side of the outer wall of the U-shaped joint, the output end of the second driving motor is connected to one end of the outer wall of the cross bar, a second limiting assembly is fixedly installed on the front surface of the isolation cavity, a fourth connecting frame is fixedly installed inside the second limiting assembly, and the fourth connecting frame is connected to one side of the outer wall of the U-shaped joint.

[0018] Preferably, a base is fixedly installed on the rear surface of the isolation cavity, a handle is provided inside the base, and a bracket is fixedly installed on one side of the outer wall of the isolation cavity.

[0019] Preferably, the cylindrical cover is movably placed inside the isolation cavity, a solid joint is fixedly sleeved on the outer surface wall of the cross bar, and the solid joint is movably placed inside the outer open window, a sampling box is fixedly installed on the outer surface wall of the solid joint, the sampling box is movably placed inside the isolation cavity, an anti-sticking plate is fixedly installed inside the sampling box, a vibration generating unit is fixedly connected to the bottom of the anti-sticking plate, and a conical lower cover plate is fixedly installed on the bottom of the sampling box.

[0020] Compared with the prior art, the beneficial effects of the present invention are:

[0021] 1. The present invention sets up an adaptive sterilization mechanism. The sterilization components and labeling detection components contained in the mechanism adopt accessory combinations and are combined with mechanical transmission, enabling free up-and-down movement inside the set cavity. Before powder sampling, the built-in sampling container is fully placed in the cavity. After starting sterilization, the detection component can first completely obtain the distribution of microorganisms on the inner wall of the cavity. According to the density of each area, by controlling the intensity and treatment duration of the sterilization component, the overall sterilization inside the cavity is completed, ensuring that the cavity is briefly in a pollution-free state after the action is executed, and the relevant components are reset. The top of the cavity can also be sealed, greatly reducing the probability of external microorganisms entering the cavity. The mechanism adopts the operation methods of chemical labeling and physical sterilization. By constructing an independent retention space, the isolation from the external air is completed. Using the combined treatment method of fluorescent labeling and ultraviolet sterilization, the microorganisms and bacteria contained in the cavity are fully processed, and the physical sealing method is adopted to further extend the time of the sterile state inside the cavity, ensuring that the drug is not contaminated by the external air during transfer, and at the same time removing the restrictions on the site environment and improving the accuracy of subsequent drug detection results.

[0022] 2. In the present invention, the data obtained by detection is analyzed by relevant modules in the electronic control component, and the distribution of microorganisms in each area inside the cavity is quickly judged. Then, the electronic control component controls the connected mechanical components to reasonably adjust the height of the sterilization component and the residence time at a certain position, realizing the ability of precise sterilization. At the same time, the two operate synchronously, enabling the quick acquisition of the real-time state inside the cavity. While ensuring sufficient sterilization, it can also timely terminate the action, avoiding the mechanism from doing useless work, greatly improving the working efficiency of the mechanism and shortening the equipment pre-preparation time.

[0023] 3. The present invention sets up a linkage and cooperation mechanism. The mechanism adopts the operation mode of gear mechanical transmission and combines with external cooperation parts, enabling flexible change of the power output direction according to the actual situation, ensuring that the work of each functional component does not interfere with each other, reducing the number of power output parts, optimizing energy consumption, and reducing the equipment usage cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 It is the three-dimensional front view structure diagram of a sampling device for lenalidomide quality detection according to the present invention;

[0025] Figure 2 It is the three-dimensional side view structure diagram of a sampling device for lenalidomide quality detection according to the present invention;

[0026] Figure 3 It is the three-dimensional flat structure diagram of a sampling device for lenalidomide quality detection according to the present invention;

[0027] Figure 4 It is a sampling device for lenalidomide quality detection according to the present invention Figure 3 The enlarged three-dimensional structure diagram at position C;

[0028] Figure 5 This is an enlarged three-dimensional view of the structure inside the isolation cavity of a sampling device for the quality inspection of lenalidomide in the present invention;

[0029] Figure 6 This is an enlarged three-dimensional view of the structure of the adaptive killing mechanism in a sampling device for the quality inspection of lenalidomide in the present invention;

[0030] Figure 7 This is an enlarged three-dimensional view of the connected structure of the cylindrical cover in a sampling device for the quality inspection of lenalidomide in the present invention;

[0031] Figure 8 This is a sampling device for the quality inspection of lenalidomide in the present invention Figure 7 An enlarged three-dimensional view of the structure at position A;

[0032] Figure 9 This is an enlarged three-dimensional view of the structure of the linkage and coordination mechanism in a sampling device for the quality inspection of lenalidomide in the present invention;

[0033] Figure 10 This is a sampling device for the quality inspection of lenalidomide in the present invention Figure 9 An enlarged three-dimensional view of the structure at position B;

[0034] Figure 11 This is an enlarged three-dimensional view of the connected structure of the sampling box in a sampling device for the quality inspection of lenalidomide in the present invention.

[0035] In the figure: 1, isolation cavity; 2, adaptive disinfection mechanism; 201, cylindrical cover; 202, external connection base; 203, ultraviolet lamp board; 204, annular frame; 205, metal protective cover; 206, ATP luminescence test component; 207, first horizontal plate; 208, annular liquid storage tank; 209, micro pump body; 210, square connector; 211, annular transition box; 212, U-shaped frame; 213, atomizing nozzle; 214, first shunt pipeline; 215, second shunt pipeline; 216, top-mounted frame; 217, load-bearing support plate; 218, lithium battery box; 219, electronic control component; 220, wire; 221, flow control valve body; 222, liquid inlet connector; 223, first limiting component; 224, splicing plate; 225, first associated frame; 3, externally opening window; 4, linkage cooperation mechanism; 401, sliding sleeve; 402, row of teeth; 403, second horizontal plate; 404, reduction gear; 405, first driving motor; 406, driving gear; 407, sliding groove; 408, electric push component; 409, connecting plate; 410, T-shaped sliding bar; 411, second associated frame; 412, extension plate; 413, first movable part; 414, third associated frame; 415, second movable part; 416, U-shaped connector; 417, cross bar; 418, second driving motor; 419, second limiting component; 420, fourth associated frame; 5, base; 6, handle; 7, bracket; 8, solid connector; 9, sampling box; 10, anti-sticking plate; 11, vibration unit; 12, conical lower cover plate. Detailed implementation mode

[0036] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described implementation clauses are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work shall fall within the protection scope of the present invention.

[0037] Please refer to the attached Figure 1 - attached Figure 11 As shown, the present invention provides a technical solution: a sampling device for the quality detection of lenalidomide, including an isolation cavity 1, an externally opening window 3 is provided inside the isolation cavity 1, an adaptive disinfection mechanism 2 is provided inside the isolation cavity 1, an externally opening window 3 is provided on the front surface of the isolation cavity 1, a base 5 is fixedly installed on the rear surface of the isolation cavity 1, a handle 6 is provided inside the base 5, and a bracket 7 is fixedly installed on one side of the outer wall of the isolation cavity 1.

[0038] Example 1, according to Figures 1 - 3 and Figures 5 - 8As shown, the adaptive killing mechanism 2 includes a cylindrical cover 201, which is movably placed inside the isolation cavity 1. A set of external connectors 202 are fixedly installed on the outer surface wall of the cylindrical cover 201. An ultraviolet lamp panel 203 is fixedly connected inside each external connector 202. A circular frame 204 is fixedly installed at the bottom of the cylindrical cover 201. A metal protective cover 205 is fixedly installed between the outer surface walls of the circular frame 204. An ATP luminescence test component 206 is arranged inside the metal protective cover 205. A first horizontal plate 207 is fixedly installed at the bottom of the circular frame 204. A circular liquid storage tank 208 and a micro pump body 209 are respectively fixedly installed at the bottom of the first horizontal plate 207. A circular transition box 211 is fixedly installed on the inner surface wall of the metal protective cover 205. The output end of the micro pump body 209 is fixedly connected to a square connector 210. A set of U-shaped frames 212 are equidistantly installed on the outer surface wall of the circular transition box 211. A set of atomizing nozzles 213 are fixedly installed inside each U-shaped frame 212. The input end of the micro pump body 209 is fixedly connected to a set of first shunt pipes 214. The liquid inlet ends of the set of first shunt pipes 214 all penetrate through the outer surface wall of the circular liquid storage tank 208 and are connected to the inside of the circular liquid storage tank 208. The outer surface wall of the square connector 210 is fixedly connected to four groups of second shunt pipes 215. The liquid discharge ends of each group of second shunt pipes 215 all penetrate through the outer surface wall of the circular transition box 211 and are connected to the inside of the circular transition box 211. The liquid inlet ends of each group of atomizing nozzles 213 all penetrate through the outer surface wall of the circular transition box 211 and are connected to the inside of the circular transition box 211. A shut-off valve body 221 is fixedly connected to the outer surface wall of the circular liquid storage tank 208. The liquid inlet end of the shut-off valve body 221 is fixedly connected to a liquid inlet connector 222. A first limiting component 223 is fixedly installed on one side of the outer wall of the isolation cavity 1. A first associated frame 225 is fixedly installed inside the first limiting component 223. Two splicing plates 224 are fixedly installed at the top of the cylindrical cover 201. The first associated frame 225 is connected to one of the splicing plates 224.

[0039] The effects achieved by the entire Example 1 are as follows: By presetting the above components, the mechanism is divided into two parts. One is the sterilization component, and the other is the labeling and detection component. The two are combined with auxiliary components and combined with mechanical transmission, and can move freely up and down inside the set cavity. Before powder sampling, the built-in sampling container is fully placed in the cavity. After starting sterilization, the detection component can first completely obtain the distribution of microorganisms on the inner wall of the cavity. According to the density of each area, by controlling the intensity and treatment duration of the sterilization component, the overall sterilization inside the cavity is completed, ensuring that the cavity is briefly in a pollution-free state after the action is executed, and the relevant components are reset, and the top of the cavity can also be sealed, greatly reducing the probability of external microorganisms entering the cavity. This method constructs an independent retention space to isolate from the outside air, uses a treatment method combining fluorescent labeling and ultraviolet sterilization to completely treat the microorganisms and bacteria contained in the cavity, and uses a physical sealing method to further extend the time of the sterile state inside the cavity, ensuring that the drug is not contaminated by the outside air during transfer, while removing the restriction on the site environment and improving the accuracy of subsequent drug detection results.

[0040] Example 2, according to Figure 6 As shown, a top-mounted frame 216 is fixedly installed at the top of the cylindrical cover 201. A load-bearing support plate 217 and a lithium battery box 218 are respectively fixedly installed at the top of the top-mounted frame 216. An electric control component 219 is fixedly installed at the top of the load-bearing support plate 217. The output end of the lithium battery box 218 is fixedly connected to a group of wires 220, and the output ends of the group of wires 220 are respectively connected to the wiring terminals of the electric control component 219.

[0041] The effects achieved by the entire Example 2 are as follows: By presetting the above components, since the set sterilization component and the labeling and detection component can work simultaneously, during the process, the data obtained by detection is analyzed by relevant modules in the electric control component 219, and the distribution of microorganisms in each area inside the cavity is quickly judged. Then, the electric control component 219 controls the connected mechanical components to reasonably adjust the height of the sterilization component and the residence time at a certain position, realizing the ability of precise sterilization. At the same time, the two operate synchronously, and the real-time state inside the cavity can be quickly obtained. While ensuring sufficient sterilization, the action can also be terminated in time to avoid the mechanism doing useless work, greatly improving the working efficiency of the mechanism and shortening the equipment pre-preparation time.

[0042] Example 3, according to Figure 1 、 Figure 3 and Figures 9 - 10As shown in the figure, the linkage and cooperation mechanism 4 includes two sliding sleeves 401. Both of the two sliding sleeves 401 are fixedly installed on the front surface of the isolation cavity 1. A row of teeth 402 is movably arranged inside each sliding sleeve 401. A second horizontal plate 403 is fixedly installed between the front surfaces of the two sliding sleeves 401. A speed reducer 404 is fixedly installed on the front surface of the second horizontal plate 403. The input end of the speed reducer 404 is fixedly connected with a first driving motor 405. A driving gear 406 is fixedly sleeved on the shaft end of the speed reducer 404. The driving gear 406 is meshed and connected with the two rows of teeth 402. A chute 407 is opened inside each row of teeth 402. An electric push component 408 is fixedly installed on the outer wall of each sliding sleeve 401. A connecting plate 409 is fixedly sleeved on the shaft end of each electric push component 408. A T-shaped sliding bar 410 is fixedly installed on the relative side of the two connecting plates 409. Each T-shaped sliding bar 410 is respectively movably arranged inside a corresponding chute 407. A second associated frame 411 is fixedly installed on the top of a row of teeth 402. An extension plate 412 is fixedly installed on the outer wall of a splicing plate 224. One end of the extension plate 412 is provided with a first movable part 413. The second associated frame 411 is connected with the first movable part 413. A third associated frame 414 is fixedly installed on the bottom of a row of teeth 402. A second movable part 415 is arranged at the bottom of the third associated frame 414.

[0043] The effect achieved by the entire embodiment 3 is that by presetting the above components, the mechanism adopts a running mode of gear mechanical transmission, combined with external cooperation components, can flexibly change the power output direction according to the actual situation, ensure that the work of each functional component does not interfere with each other, reduce the number of power output components, optimize energy consumption, and reduce the equipment use cost.

[0044] Embodiment 4, according to Figures 4 - 5 、 Figure 9 and Figure 11 As shown in the figure, a U-shaped joint 416 is arranged on one side of the outer wall of the second movable part 415. A cross bar 417 is movably inserted between the two sides of the inner wall of the U-shaped joint 416. A second driving motor 418 is fixedly installed on one side of the outer wall of the U-shaped joint 416. The output end of the second driving motor 418 is connected with one end of the outer wall of the cross bar 417. A second limiting component 419 is fixedly installed on the front surface of the isolation cavity 1. A fourth associated frame 420 is fixedly installed inside the second limiting component 419. The fourth associated frame 420 is connected with one side of the outer wall of the U-shaped joint 416. A solid joint 8 is fixedly sleeved on the outer wall of the cross bar 417, and the solid joint 8 is movably placed inside the outer open window 3. A sampling box 9 is fixedly installed on the outer wall of the solid joint 8. The sampling box 9 is movably placed inside the isolation cavity 1. An anti-sticking plate 10 is fixedly installed inside the sampling box 9. A vibration unit 11 is fixedly connected to the bottom of the anti-sticking plate 10. A conical lower cover plate 12 is fixedly installed at the bottom of the sampling box 9.

[0045] The effects achieved by the entire Embodiment 4 are as follows: By presetting the above components and the sampling container, the powder sampling and release can be autonomously completed under the cooperation of the connected collaborative components. With the intervention of the built-in vibration component and special materials, when the powder is released, the retention of the drug can be maximally prevented, the cleanliness inside the equipment can be improved, the equipment cleaning time can be extended, and the equipment can have the ability to continuously work.

[0046] The working principle of the entire equipment is as follows: In the preparation stage, the relevant personnel lift the grip 6, first place the equipment flat on the table or other platforms, and ensure that the bottom of the bracket 7 is fully in contact with the platform. Check the energy storage situation in the lithium battery box 218 to ensure its fullness, aiming to provide energy for the electrical components contained in the equipment. Manually operate the throttle valve body 221 to open its internal channel, and an appropriate amount of fluorescent agent can be injected into the annular liquid storage tank 208 from the liquid inlet joint 222.

[0047] In the first execution stage, the electronic control component 219 controls the opening of the micro pump body 209, the impeller inside rotates, and starts to pump the liquid in the annular liquid storage tank 208. Then it is transported through the first shunt pipeline 214 and converges into the square joint 210. As the liquid level inside rises, with the assistance of hydraulic pressure, part of the liquid can be evenly squeezed into each second shunt pipeline 215, and the liquid is further transferred to the annular transition tank 211. Finally, through the above principle, the fluorescent agent can fully enter each atomizing nozzle 213. After compression, it diffuses outward in an atomized form and finally covers the inner wall of the cavity. At this time, the ATP luminescence test component 206 in the metal protective cover 205 is in the open state. Using the reaction of luciferase with adenosine triphosphate in microbial cells, the ATP luminescence test component 206 can fully read the fluorescence signal intensity and import it into the relevant modules in the electronic control component 219 in real time through the built-in wiring of the equipment, clearly obtaining the microbial distribution in each area of the inner wall of the isolation cavity 1. At the same time, turn on an electric push component 408 to extend its inner shaft outward. Using the physical characteristics of the first movable part 413, drive the connecting plate 409 and its connected components to move horizontally, gradually making a corresponding row of teeth 402 mesh with the driving gear 406. Further turn on the first driving motor 405. After being processed by the speed reducer 404, the low-speed power is directly transmitted to the driving gear 406. Using the movable connection of the chute 407, the T-shaped slide bar 410 and the first limit component 223, drive the connected components to slowly move downward from top to bottom, continuously complete the marking detection of the inner wall of the isolation cavity 1. After completion, stop the power and reset. Then, according to the obtained data, the electronic control component 219 controls the opening of the driving component again and completes the power supply of each ultraviolet lamp board 203. According to the microbial distribution in each area of the inner wall of the isolation cavity 1, reasonably control the height and ultraviolet irradiation time. After completion, reset the component again. At this time, the metal protective cover 205 completes the sealing of the top of the isolation cavity 1.

[0048] Sampling stage: When the component is reset for the second time, it indicates that the disinfection work of the device has been completed. Then, relevant personnel hold the device and start sampling. After the bottom of the isolation cavity 1 is aligned with the top of the sample, two electric push components 408 are synchronously activated. The inner shafts of the two components move in opposite directions, causing one row of teeth 402 to disengage from the driving gear 406 and the other to engage. After that, the first driving motor 405 is activated again to drive the sampling box 9 to slowly move down. Utilizing the structural characteristics of the conical lower cover plate 12, the sampling box 9 can be easily inserted into the sample until it is completely submerged, completing the powder sampling. At this time, the vibrating unit 11 is in the on state, and the generated vibration is used to accelerate the detachment of the powder adhering to the outer wall of the structure. Finally, under the action of the mechanical components, the sampling box 9 containing the powder can enter the isolation cavity 1 again and start the drug transfer process.

[0049] Release stage: The mechanical components lower the sampling box 9 to a reasonable height. According to the position of the collection container, the orientation of the device is adjusted. The second driving motor 418 is activated to drive the sampling box 9 to complete the angular deviation and discharge the material in a dumping manner. Finally, the sampling box 9 is rotated 180°. At the same time, the vibrating unit 11 is in the on state to assist in accelerating the release of the powder in the sampling box 9.

[0050] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. A sampling device for quality detection of lenalidomide, characterized in that: It comprises an isolation cavity (1), wherein an outward-opening window (3) is provided inside the isolation cavity (1); An adaptive killing mechanism (2) is provided inside the isolation cavity (1), and an outward-opening window (3) is provided on the front surface of the isolation cavity (1); The self-adaptive killing mechanism (2) comprises a columnar cover (201), a group of external seats (202) are fixedly mounted on the outer wall of the columnar cover (201), each of the external seats (202) is fixedly connected to an ultraviolet lamp board (203), an annular frame (204) is fixedly mounted on the bottom of the columnar cover (201), a metal protective cover (205) is fixedly mounted between the outer walls of the annular frame (204), an ATP luminescent test component (206) is arranged inside the metal protective cover (205), a first transverse plate (207) is fixedly mounted on the bottom of the annular frame (204), an annular liquid storage tank (208) and a micro pump body (209) are fixedly mounted on the bottom of the first transverse plate (207), and an inner surface wall of the metal protective cover (205) is fixedly mounted. An annular transition box (211) is installed, the output end of the micro pump body (209) is fixedly connected to a square connector (210), a group of U-shaped frames (212) are equidistantly installed on the outer wall of the annular transition box (211), a group of atomizing nozzles (213) are fixedly installed inside each of the U-shaped frames (212), a top frame (216) is fixedly installed on the top of the column cover (201), a load-bearing support plate (217) and a lithium battery box (218) are fixedly installed on the top of the top frame (216), an electric control component (219) is fixedly installed on the top of the load-bearing support plate (217), the output end of the lithium battery box (218) is fixedly connected to a group of wires (220), and the output ends of a group of the wires (220) are all connected to the wiring terminals of the electric control component (219).

2. The lenalidomide quality detection sampling device according to claim 1, characterized in that: The input end of the micro pump body (209) is fixedly connected to a group of first shunt pipes (214), and the liquid inlet ends of the group of first shunt pipes (214) all penetrate the outer wall of the annular liquid storage tank (208) and are connected to the interior of the annular liquid storage tank (208). The outer wall of the square joint (210) is fixedly connected to four groups of second shunt pipes (215), and the liquid discharge end of each group of the second shunt pipes (215) penetrates the outer wall of the annular transition box (211) and is connected to the interior of the annular transition box (211). The liquid inlet end of each group of the atomizing nozzles (213) penetrates the outer wall of the annular transition box (211) and is connected to the interior of the annular transition box (211).

3. The sampling device for lenalidomide quality detection according to claim 1, characterized in that: The outer wall of the annular liquid storage tank (208) is fixedly connected to a shutoff valve body (221), and the liquid inlet end of the shutoff valve body (221) is fixedly connected to a liquid inlet connector (222).

4. The sampling device for quality detection of lenalidomide according to claim 1, characterized in that: A first limiting assembly (223) is fixedly mounted on one side of the outer wall of the isolation cavity (1); a first associated frame (225) is fixedly mounted inside the first limiting assembly (223); two splicing plates (224) are fixedly mounted on the top of the cylindrical cover (201); the first associated frame (225) is connected to one of the splicing plates (224).

5. The sampling device for quality detection of lenalidomide according to claim 4, characterized in that: The linkage coordination mechanism (4) comprises two sliding sleeves (401), both of which are fixedly mounted on the front surface of the isolation cavity (1), and each of which has a row of teeth (402) movably arranged inside.

6. The sampling device for quality detection of lenalidomide according to claim 5, characterized in that: A second transverse plate (403) is fixedly installed between the front surfaces of the two sliding sleeves (401), a reducer (404) is fixedly installed on the front surface of the second transverse plate (403), an input end of the reducer (404) is fixedly connected to a first driving motor (405), a driving gear (406) is fixedly sleeved on the shaft end of the reducer (404), and the driving gear (406) is meshingly connected to the two rows of teeth (402).

7. The sampling device for quality detection of lenalidomide according to claim 5, characterized in that: A slide groove (407) is provided inside each row of teeth (402), an electric push assembly (408) is fixedly installed on the outer wall of each sleeve (401), a connecting plate (409) is fixedly sleeved on the axial end of each electric push assembly (408), and a T-shaped slide bar (410) is fixedly installed on the opposite side of the two connecting plates (409), and each T-shaped slide bar (410) is movably arranged inside a corresponding slide groove (407).

8. The sampling device for quality detection of lenalidomide according to claim 5, characterized in that: A second associated frame (411) is fixedly mounted on the top of one of the row of teeth (402); an extension plate (412) is fixedly mounted on the outer wall of one of the splicing plates (224); a first movable member (413) is disposed at one end of the extension plate (412); the second associated frame (411) and the first movable member (413) are connected; a third associated frame (414) is fixedly mounted on the bottom of one of the row of teeth (402); a second movable member (415) is disposed at the bottom of the third associated frame (414); a U-shaped joint (415) is disposed on one side of the outer wall of the second movable member (415); 416), a cross bar (417) is movably inserted between the two sides of the inner wall of the U-shaped joint (416), a second drive motor (418) is fixedly installed on one side of the outer wall of the U-shaped joint (416), the output end of the second drive motor (418) is connected to one end of the outer wall of the cross bar (417), a second limit assembly (419) is fixedly installed on the front surface of the isolation cavity (1), a fourth associated frame (420) is fixedly installed inside the second limit assembly (419), and the fourth associated frame (420) is connected to one side of the outer wall of the U-shaped joint (416).

9. The sampling device for quality detection of lenalidomide according to claim 1, characterized in that: A base (5) is fixedly mounted on the rear surface of the isolation cavity (1), a handle (6) is provided inside the base (5), and a bracket (7) is fixedly mounted on one side of the outer wall of the isolation cavity (1).

10. The sampling device for quality detection of lenalidomide according to claim 7, characterized in that: The cylindrical cover (201) is movably placed inside the isolation cavity (1); the outer wall of the cross bar (417) is fixedly sleeved with a solid joint (8), and the solid joint (8) is movably placed inside the outward-opening window (3); a sampling box (9) is fixedly installed on the outer wall of the solid joint (8); the sampling box (9) is movably placed inside the isolation cavity (1); an anti-sticking plate (10) is fixedly installed inside the sampling box (9); the bottom of the anti-sticking plate (10) is fixedly connected to a vibration unit (11); and the bottom of the sampling box (9) is fixedly installed with a conical lower cover plate (12).

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