Inhibitor of ubiquitin specific protease 1 and application thereof

Abstract

The invention discloses an inhibitor compound of ubiquitin specific protease 1 and application of the inhibitor compound, and particularly relates to a compound shown in a formula (I). Or enantiomers, diastereoisomers, racemate, tautomers, stereoisomers, geometric isomers, nitrogen oxides, metabolites or pharmaceutically acceptable salts, esters, solvates, hydrates, isotope labeled compounds (preferably deuterated compounds) or prodrugs of the compounds. # imgabs0 #

Description

Inhibitors of ubiquitin-specific protease 1 and their use

[0001] The present invention claims priority to Chinese patent application CN202211377621.2 filed on November 4, 2022, and Chinese patent application CN202310723839.7 filed on June 16, 2023, and incorporates their entire contents into this document by reference. Technical Field

[0002] The present invention relates to the field of medicine, and in particular to an inhibitor compound of ubiquitin-specific protease 1 and applications thereof. Background Art

[0003] Ubiquitination is a very common post-translational modification, in which ubiquitin is added to target proteins via an isopeptide bond. In addition to its role in protein degradation, ubiquitin also has many important non-protein degradation functions, such as DNA damage repair, DNA replication, transcriptional regulation, membrane trafficking, and endocytosis. It controls the levels, location, and activity of many proteins and participates in most cellular processes, including signal transduction, the cell cycle, growth, and apoptosis. Similar to other post-translational modifications, protein ubiquitination is a reversible process, reversed by deubiquitinating enzymes acting on ubiquitinated substrates to catalyze the removal of polyubiquitin chains or monoubiquitin.

[0004] The deubiquitinating enzyme activity of USP (Ubiquitin-specific peptidases) is closely linked to the cofactor UAF1, which enhances USP1's catalytic activity. UAF1 also stabilizes USP1's structure after binding to it, allowing it to better bind to substrates. The USP1 / UAF1 complex has three primary cellular functions, the most relevant of which are interstrand cross-link repair in the Fanconi anemia (FA) pathway and DNA translesion repair. Inhibiting USP1 from deubiquitinating substrates increases the error rate during DNA replication, thereby increasing cell mortality. In BRCA-deficient cells, knocking out USP1 significantly reduces tumor cell growth. Studies on the DNA replication process have found that in the absence of BRCA, inhibiting USP1 will block the deubiquitination of PCNA protein, leading to unstable replication forks, incomplete DNA replication, genomic instability, and cell death or cancer.

[0005] USP1 inhibitors and their various salt forms can be used as single agents to treat tumors with BRCA1 / 2 mutations, ATM mutations, PARP inhibitor-resistant tumors, P53 mutations, or tumors with two or more mutations simultaneously, such as breast cancer and ovarian cancer.

[0006] USP1 inhibitors and their various salt forms can be used in combination with chemotherapy drugs, PARP inhibitors, or other types of inhibitors to treat tumors with BRCA1 / 2 mutations, ATM mutations, PARP inhibitor-resistant tumors, P53 mutations, or tumors with two or more mutations simultaneously, such as breast cancer and ovarian cancer.

[0007] USP1 inhibitors and their various salts can be used alone or in combination with chemotherapy drugs or PARP inhibitors or other types of inhibitors to treat cancers with homologous recombination deficiency high (HR High).

[0008] Summary of the Invention

[0009] Through in-depth research and creative discoveries, the inventors of this application have obtained novel compounds that can inhibit USP1. These compounds can be used to treat and / or prevent diseases or conditions related to the regulation of ubiquitin-specific protease 1 (USP1).

[0010] To this end, the present invention provides the following embodiments:

[0011] Embodiment 1: A compound of Formula I, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof.

[0012] in:

[0013] Ring A is selected from C6-C10 aryl, 5-10 membered heteroaromatic ring group (preferably 5-7 membered heteroaromatic ring group), 4-10 membered heterocyclyl group (preferably 4-7 membered heterocyclyl group) and cyclopentadienyl ring group, and the C6-C10 aryl, 5-10 membered heteroaromatic ring group, 4-10 membered heterocyclyl group and cyclopentadienyl ring are optionally substituted by substituents R1, R2, R3, R8, R9;

[0014] Preferably, ring A is selected from a C6-C10 aryl group, a 5-6 membered heteroaromatic ring group, a 5-6 membered heterocyclic group, and a cyclopentadienyl ring group, and the C6-C10 aryl group, the 5-6 membered heteroaromatic ring group, the 5-6 membered heterocyclic group, and the cyclopentadienyl ring group are optionally substituted by substituents R1, R2, R3, R8, and R9;

[0015] More preferably, ring A is selected from a C6-C10 aryl group, a 5-membered heteroaromatic ring group, a 6-membered heteroaromatic ring group, a 5-membered heterocyclic group, a 6-membered heterocyclic group, and a cyclopentadienyl ring group, wherein the 5-membered heteroaromatic ring group and the 5-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; the 6-membered heteroaromatic ring group and the 6-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; and these ring groups are optionally substituted with substituents R1, R2, R3, R8, and R9;

[0016] Further preferably, ring A is selected from pyrimidine ring group, pyridine ring group, triazinyl group (e.g., 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl), pyranyl, thiopyranyl, phenyl, naphthyl, cyclopentadienyl ring group, pyrrole ring group, pyrazol ring group, imidazole ring group, furanyl, thienyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, dihydropyrazole ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane, and these ring groups are optionally substituted with substituents R1, R2, R3, R8, and R9;

[0017] Further more preferably, ring A is selected from a benzene ring, a pyrimidine ring, a pyridine ring, a pyrrole ring, a pyrazole ring, an imidazole ring, and a triazole ring, and the benzene ring, pyrimidine ring, pyridine ring, pyrrole ring, pyrazole ring, imidazole ring, and triazole ring are optionally substituted with substituents R1, R2, R3, R8, and R9;

[0018] Further more preferably, ring A is selected from a pyrimidine ring, a pyridine ring, and a pyrazole ring, and the pyrimidine ring, the pyridine ring, and the pyrazole ring are optionally substituted by substituents R1, R2, R3, R8, and R9;

[0019] Even more preferably, Ring A is selected from

[0020] Still further preferably, Ring A is selected from:

[0021] Even more preferably, Ring A is selected from

[0022] Even more preferably, Ring A is selected from

[0023] Even more preferably, Ring A is selected from

[0024] R1 is selected from 5-7 membered heteroaromatic ring group, saturated or partially unsaturated 4-7 membered heterocyclic group, 6-10 membered aryl group, C3-C8 cycloalkyl group, and the 5-7 membered heteroaromatic ring group, saturated or partially unsaturated 4-7 membered heterocyclic group, 6-10 membered aryl group, C3-C8 cycloalkyl group is optionally substituted by R a 、R b 、R c replaced by;

[0025] Preferably, R1 is selected from 5-6 membered heteroaromatic ring group, 5-6 membered heterocyclic group, 6-10 membered aryl group, and the 5-6 membered heteroaromatic ring group, 5-6 membered heterocyclic group, 6-10 membered aryl group is optionally substituted by R a 、R b 、R c replaced by;

[0026] More preferably, R1 is selected from a 5-membered heteroaromatic ring group, a 6-membered heteroaromatic ring group, and a 6-membered aryl group, wherein the 5-membered heteroaromatic ring group contains 1-2 heteroatoms selected from N atoms, O atoms, and S atoms (preferably N atoms); the 6-membered heteroaromatic ring group contains 1-2 heteroatoms selected from N atoms, O atoms, and S atoms (preferably N atoms); these ring groups are optionally substituted with R a 、R b 、R c replaced by;

[0027] Further preferably, R1 is selected from: pyrimidine ring group, pyridine ring group, triazine group (such as 1,2,3-triazine group, 1,2,4-triazine group, 1,3,5-triazine group), pyranyl, thiopyranyl, phenyl, naphthyl, cyclopentadienyl ring group, pyrrole ring group, pyrazole ring group, imidazole ring group, furanyl, thienyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, dihydropyrazole ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane; these ring groups are optionally substituted by R a 、R b 、R c replaced by;

[0028] Still further preferably, R1 is selected from pyrimidine ring group, pyridine ring group, pyrazole ring group, pyrrole ring group, phenyl group, and these ring groups are optionally substituted by R a 、R b 、R c replaced by;

[0029] Still further preferably, R1 is selected from pyrimidine ring group, pyridine ring group, pyrazole ring group, phenyl group, and these ring groups are optionally substituted by R a 、R b 、R c replaced by;

[0030] Even more preferably, R1 is selected from:

[0031] Still more preferably, R1 is selected from:

[0032] More preferably, R1 is selected from:

[0033] Even more preferably, R1 is selected from: Among them, R a 、R b 、R c Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, C1-C6 alkyloxy-C1-C6 alkyl, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a 、R b 、R c and each is independently selected from the group consisting of hydrogen, halogen, cyano, C1-C6 alkyl, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by C1-C6 alkoxy (optionally deuterated), C1-C6 alkoxy which is unsubstituted or optionally substituted by 1-9 halogen atoms (optionally deuterated), C1-C6 alkylthio, C1-C6 alkoxy which is unsubstituted or optionally substituted by C1-C6 alkoxy More preferably, R a 、R b 、R cEach is independently selected from the group consisting of hydrogen, chlorine, cyano, isopropyl, methyl, tert-butyl, trifluoromethyl, methoxy, ethoxy, methoxymethoxy, methoxyethoxy, trideuteromethoxy, difluoromethoxy, fluoromethoxy, cyclopropyl, difluorocyclopropyl, methoxymethyl-substituted cyclopropyl, hydroxy-substituted cyclopropyl, methylthio, dimethylamino, isopropylamino, oxetanyl, and N-methylcarbamoyl;

[0034] Even more preferably, R1 is selected from: Among them, R a 、R b 、R c Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), wherein the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted by one or more halogen or deuterium; more preferably, R a 、R b 、R c are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a 、R b 、R c Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuterated methoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a 、R b 、R c Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy;

[0035] More preferably, R1 is selected from any one of the groups 1) to 5):

[0036] 1) R a1 、R b1 、R c1Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl; preferably, R a1 、R b1 、R c1 are each independently selected from the group consisting of: hydrogen, C1-C6 alkyl, C1-C6 alkoxy (optionally deuterated) which is unsubstituted or optionally substituted by C1-C6 alkoxy, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, halogen, C1-C6 alkylthio, cyano, amino which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl groups; more preferably, R a1 、R b1 、R c1 Each is independently selected from the group consisting of hydrogen, isopropyl, methoxy, cyclopropyl, methoxyethoxy, methyl, chloro, tert-butyl, ethoxy, trideuteromethoxy, difluorocyclopropyl, methylthio, cyano, and dimethylamino;

[0037] 2) R a2 、R b2 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a2 、R b2 Each is independently selected from: hydrogen, C1-C6 alkyl, amino which is unsubstituted or optionally substituted with 1-2 C1-C6 alkyl groups, C1-C6 alkoxy, cyano, C3-C8 cycloalkyl, C1-C6 alkylthio; more preferably, R a2 、R b2 Each is independently selected from the group consisting of: hydrogen, isopropyl, methyl, dimethylamino, methoxy, cyano, cyclopropyl, methylthio, isopropylamino;

[0038] 3) R a3 、R b3Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a3 、R b3 Each is independently selected from: hydrogen, halogen, a 4-7 membered heterocyclic group containing one heteroatom selected from a N atom, an O atom, or a S atom as a ring atom, a cyano group, a C1-C6 alkyl group, a C3-C8 cycloalkyl group which is unsubstituted or optionally substituted by a C1-C6 alkyl group which is substituted by a C1-C6 alkoxy group, or a C1-C6 alkyl group which is unsubstituted or optionally substituted by 1-9 halogen atoms; more preferably, R a3 、R b3 Each is independently selected from the group consisting of: hydrogen, chlorine, oxetanyl, cyano, isopropyl, methoxymethyl-substituted cyclopropyl, trifluoromethyl, methyl;

[0039] 4) R a4 、R b4 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a4 、R b4 Each independently selected from: hydrogen, cyano, C1-C6 alkyl, halogen; More preferably, R a4 、R b4 Each independently selected from: hydrogen, cyano, isopropyl, chloro;

[0040] 5) R a5 、R b5 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a5 、R b5 Each is independently selected from: hydrogen, C3-C8 cycloalkyl which is unsubstituted or optionally substituted with hydroxy, C1-C6 alkyl, amino C1-C6 acyl which is unsubstituted or optionally substituted with 1-2 C1-C6 alkyl, C1-C6 alkylthio; more preferably, R a5 、Rb5 Each is independently selected from: hydrogen, hydroxy-substituted cyclopropyl, isopropyl, N-methylcarbamoyl, methylthio;

[0041] Still more preferably, R1 is selected from any one of the groups 1) to 13):

[0042] 1) R a11 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a11 is selected from: hydrogen, C1-C6 alkyl; more preferably, R a11 Selected from: hydrogen, isopropyl;

[0043] 2) R a12 、R b12 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 - C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a12 、R b12 are each independently selected from the group consisting of: hydrogen, C1-C6 alkyl, C1-C6 alkoxy (optionally deuterated) which is unsubstituted or optionally substituted by C1-C6 alkoxy, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, halogen, C1-C6 alkylthio, cyano, amino which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl groups; more preferably, R a12 、R b12 Each is independently selected from the group consisting of hydrogen, methoxy, difluoromethoxy, ethyl, cyclopropyl, isopropyl, methoxyethoxy, methyl, chloro, tert-butyl, ethoxy, trideuteromethoxy, difluorocyclopropyl, methylthio, cyano, and dimethylamino;

[0044] 3) R a13 、R b13 、R c13Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a13 、R b13 、R c13 Each is independently selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, C3-C8 cycloalkyl; more preferably, R a13 、R b13 、R c13 Independently selected from: hydrogen, methoxy, methyl, cyclopropyl;

[0045] 4) R a21 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a21 is selected from: hydrogen, C1-C6 alkyl, amino which is unsubstituted or optionally substituted with 1-2 C1-C6 alkyl groups; more preferably R a21 Selected from: hydrogen, isopropyl, isopropylamino;

[0046] 5) R a22 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-Rs1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a22 is selected from: hydrogen, C1-C6 alkoxy; more preferably, R a22 Selected from: hydrogen, methoxy;

[0047] 6) R a23 、R b23 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 Re1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a23 、R b23 Each is independently selected from: hydrogen, C1-C6 alkoxy, cyano, C3-C8 cycloalkyl, C1-C6 alkylthio, C1-C6 alkyl; More preferably, R a23 、Rb23 Each is independently selected from: hydrogen, methoxy, cyano, cyclopropyl, methylthio, methyl;

[0048] 7) R a24 、R b24 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a24 、R b24 Each is independently selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl; more preferably, R a24 、R b24 Each independently selected from: hydrogen, methoxy, methyl;

[0049] 8) R a31 、R b31 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a31 、R b31 Each is independently selected from: hydrogen, halogen, a 4-7 membered heterocyclic group containing one heteroatom selected from a N atom, an O atom, or a S atom as a ring atom, a cyano group, a C1-C6 alkyl group, a C3-C8 cycloalkyl group which is unsubstituted or optionally substituted by a C1-C6 alkyl group which is substituted by a C1-C6 alkoxy group, or a C1-C6 alkyl group which is unsubstituted or optionally substituted by 1-9 halogen atoms; more preferably, R a31 、R b31 Each is independently selected from the group consisting of: hydrogen, chlorine, oxetanyl, cyano, isopropyl, methoxymethyl-substituted cyclopropyl, trifluoromethyl, methyl;

[0050] 9) R a41 、R b41 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1, where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a41 、R b41 Each is independently selected from: hydrogen, cyano, C1-C6 alkyl; more preferably, R a41 、R b41 Each independently selected from: hydrogen, cyano, isopropyl;

[0051] 10) R a42 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a42 is selected from: hydrogen, C1-C6 alkyl; more preferably, R a42 Selected from: hydrogen, isopropyl;

[0052] 11) R a43 、R b43 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a43 、R b43 Each independently selected from: hydrogen, C1-C6 alkyl, halogen; More preferably, R a43 、R b43 Each independently selected from: hydrogen, isopropyl, chloro;

[0053] 12) R a51 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a51 is selected from: hydrogen, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by hydroxy, C1-C6 alkyl, amino C1-C6 acyl which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl groups; more preferably, R a51 Selected from: hydrogen, hydroxy substituted cyclopropyl, isopropyl, N-methylcarbamoyl;

[0054] 13) R a52 、R b52 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a52 、R b52 Each is independently selected from: hydrogen, C3-C8 cycloalkyl, C1-C6 alkylthio; more preferably, R a52 、R b52 Each independently selected from: hydrogen, cyclopropyl, methylthio;

[0055] Still more preferably, R1 is selected from any one of the groups 1) to 5):

[0056] 1) R a12 、R b12 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogen or deuterium; preferably, R a12 、R b12 are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a12 、R b12 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, difluoromethoxy, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a12 、R b12Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy;

[0057] 2) R a23 、R b23 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogen or deuterium; preferably, R a23 、R b23 are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a23 、R b23 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, and difluorocyclopropyl; R a23 、R b23 More preferably, it is selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuterated methoxy;

[0058] 3) R a24 、R b24 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogen or deuterium; preferably, R a24 、R b24are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a24 、R b24 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a24 、R b24 Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy;

[0059] 4) R a31 、R b31 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NRd1Re1 (wherein R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogens; preferably, R a31 、R b31 are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a31 、R b31 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a31 、R b31 Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy;

[0060] 5) R a52 、R b52 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where Rd1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogen or deuterium; preferably, R a52 、R b52 are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a52 、R b52 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a52 、R b52 Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy;

[0061] R3 is selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted with 1 or multiple halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium substitution; preferably, R3 is selected from: hydrogen, C1-C6 alkyl, halogen, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C1-C6 haloalkoxy, more preferably, R3 is selected from: hydrogen, C1-C6 alkyl; more preferably, R3 is selected from: hydrogen, methyl;

[0062] R2 is selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1, where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium substitution; preferably, R2 is selected from: hydrogen, C1-C6 alkyl, halogen, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C1-C6 haloalkoxy, C1-C6 acyl; more preferably, R2 is selected from: hydrogen, C1-C6 alkyl, C1-C6 acyl, C3-C8 cycloalkyl, halogen; more preferably, R2 is selected from: H, halogen, C1-C3 alkyl, C1-C3 acyl, C3-C4 cycloalkyl; more preferably, R2 is selected from: hydrogen, methyl, ethyl, cyclopropyl, chlorine, fluorine, acetyl;

[0063] R8 and R9 are each independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), (where X6 is O, S or NR x Where N is the attachment site, R z is an optionally substituted C1-C6 alkyl group, R x is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is an optionally substituted C1-C6 alkyl, an optionally substituted C2-C8 alkenyl, an optionally substituted C2-C8 alkynyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 alkyloxy, an optionally substituted hydroxyC1-C6 alkyl, or an optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, optionally substituted C1-C6 alkylsulfinyl (-S(O)R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkylsulfonyl (-S(O)2R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted di(C1-C6 alkyl)phosphinyl ( where R g 、R h is an optionally substituted C1-C6 alkyl), wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from optionally substituted H, optionally substituted C1-C6 alkyl or optionally substituted C3-C8 cycloalkyl), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl group or an optionally substituted C3-C6 cycloalkyl group), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group), -S(O)R f (where R f is an optionally substituted C1-C6 alkyl), -S(O)2R f (where R f is an optionally substituted C1-C6 alkyl), (where Rg 、R h (e.g., an optionally substituted C1-C6 alkyl group), wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl groups, C3-C6 cycloalkyl groups, C1-C6 alkyloxy groups, hydroxy groups, C1-C6 alkylthio groups, amino groups, or deuterium groups;

[0064] Preferably, R8 and R9 are each independently selected from the group consisting of hydrogen, C1-C6 acyl which is unsubstituted or optionally substituted by 1-9 halogen atoms or by C3-C8 cycloalkyl or by C3-C8 cycloalkyloxy, aminoC1-C3 acyl which is unsubstituted or optionally substituted by C3-C8 cycloalkyl or by 1-2 C1-C6 alkyl (optionally deuterated), oxyC1-C3 acyl which is unsubstituted or optionally substituted by C3-C8 cycloalkyl, amino which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl or C3-C8 cycloalkyl, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by C1-C6 alkyl, C1-C6 alkylsulfonyl, and di(C1-C6 alkyl)phosphinyl.

[0065] More preferably, R8 and R9 are each independently selected from: H, C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl or C3-C6 cycloalkyloxy), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group), -NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl or C3-C6 cycloalkyl), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R his C1-C6 alkyl), C1-C6 alkyl-substituted C3-C6 cycloalkyl; more preferably selected from: hydrogen, methyl, acetyl, trifluoropropionyl, propionyl, cyclopropylcarbamoyl, trifluoroacetyl, N-cyclopropylcarbamoyl, N-isopropylcarbamoyl, N-trideuterated methylcarbamoyl, azetidinylcarbamoyl, N,N-dimethylcarbamoyl, N-methyl-N-cyclopropylcarbamoyl, carbamoyl, N-methylcarbamoyl, cyclopropyloxycarbamoyl, methylamino, methylcyclopropylamino, trifluoromethyl, methylcyclopropyl, ethyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl;

[0066] More preferably, R8 and R9 are each independently selected from: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, or

[0067] R2, R8 or R2, R9 together with the atoms to which they are attached form Wherein * represents the position of the atom to which R2, R8 or R2, R9 are connected; preferably R2, R8 or R2, R9 together with the atoms to which they are connected form Where * indicates the position of the atom to which R2, R8 or R2, R9 are respectively connected;

[0068] Ring B is selected from 5-15 membered heteroaromatic ring group, 4-15 membered heterocyclic group, C4-C7 cycloalkyl group, 6-10 membered aryl group and bridged ring C4-C20 hydrocarbon group, and the 5-15 membered heteroaromatic ring group, 4-15 membered heterocyclic group, C4-C7 cycloalkyl group, 6-10 membered aryl group and bridged ring C4-C20 hydrocarbon group are optionally substituted by R 41 、R 42 , replaced by R5;

[0069] Preferably, the B ring is selected from a 5-14 membered heteroaromatic ring group, a 4-14 membered heterocyclic group, a C5-C6 cycloalkyl group, a 6 membered aryl group and a bicyclic bridged C4-C10 hydrocarbon group, and the 5-14 membered heteroaromatic ring group, the 4-14 membered heterocyclic group, the C5-C6 cycloalkyl group, the 6 membered aryl group and the bicyclic bridged C4-C10 hydrocarbon group are optionally substituted by R 41 、R 42 , replaced by R5;

[0070] More preferably, the B ring is selected from a 5-membered heteroaromatic ring group, a 6-membered heteroaromatic ring group, a 4-membered heterocyclic group, a 5-membered heterocyclic group, a 6-membered heterocyclic group, a 7-14-membered bicyclic or tricyclic condensed heteroaromatic ring group, a 7-14-membered bicyclic or tricyclic condensed heterocyclic group, a C5-C6 cycloalkyl group, a 6-membered aryl group, and a bicyclic bridged C4-C10 hydrocarbon group, wherein the 5-membered heteroaromatic ring group and the 5-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; the 6-membered heteroaromatic ring group and the 6-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms (preferably N atoms); the 4-membered heterocyclic group contains 1-2 heteroatoms selected from N atoms; and these ring groups are optionally substituted with R 41 、R 42 , replaced by R5;

[0071] Further preferably, the B ring is selected from pyrrole ring group, pyrazol ring group, imidazole ring group, furan ring group, thienyl ring group, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, dihydropyrazol ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, tetrahydropyrrole ring group, pyridine ring group, pyrimidine ring group, triazinyl (e.g., 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl), pyranyl, thiopyranyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane, hexahydropyrazinyl, azetidinyl, indolyl, 5-azaindole Indole, pyrrolo[2,3-d]pyrimidinyl, 5,6-diazaindolyl, 6-azaindolyl, 7-azaindolyl, pyrazolo[3,4-b]pyridinyl, pyrrolo[2,3-c]pyridazinyl, thieno[2,3-d]imidazolyl, thieno[2,3-d]imidazolyl, pyrazolo[3,4-c]pyridinyl, benzothiazolyl, benzimidazolyl, benzoxazolyl, benzothienyl, quinolinyl, isoquinolinyl, benzofuranyl, indolizinyl, quinoxalinyl, indazolyl, pyrrolopyrimidinyl, furopyridinyl, isoindolyl, cyclohexyl, phenyl, bicyclo[1.1.1]pentanyl, bicyclo[1.2.2]heptanyl, bicyclo[2.2.2]octanyl, wherein these ring groups are optionally substituted with R 41 、R 42 , replaced by R5;

[0072] More preferably, the B ring is selected from a benzene ring, pyridine, pyrimidine, bicyclo[1.2.2]heptyl, bicyclo[2.2.2]octyl, and the benzene ring, pyridine, pyrimidine, bicyclo[1.2.2]heptyl, bicyclo[2.2.2]octyl is optionally substituted with R 41 、R 42 , replaced by R5;

[0073] Even more preferably, Ring B is selected from

[0074] Even more preferably, Ring B is selected from

[0075] More preferably, the B ring is selected from

[0076] More preferably, the B ring is selected from

[0077] R 41 、R 42 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NRd3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R 41 、R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; more preferably, R 41 、R 42 Each is independently selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxyl; more preferably, R 41 、R 42 Each independently selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxyl;

[0078] R5 is selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2, where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-15 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, optionally substituted 4-15 membered heteroaryl, optionally substituted 6-10 membered aryl, optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms , C1-C6 alkyl, deuterated C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, deuterated C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; the 4-15 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms is preferably selected from: dihydropyrazole ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, tetrahydropyrrole ring group, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4- The 4-15 membered heteroaryl is preferably selected from the group consisting of: pyrrole ring group, pyrazole ring group, imidazole ring group, furan ring group, thiophene ring group, oxazolyl group, thiazolyl group, isoxazolyl group, isothiazolyl group, pyridine ring group, pyrimidine ring group, triazine group (e.g., 1,2,3-triazine group, 1,2,4-triazine group, 1,3,5-triazine group), pyranyl group, thiopyranyl group, indolyl group, 5-azaindolyl group, pyrrolyl group, pyrrolyl group, pyrimidine ring group, pyrrolyl ... pyrimidinyl, 5,6-diazaindolyl, 6-azaindolyl, 7-azaindolyl, pyrazolo[3,4-b]pyridinyl, pyrrolo[2,3-c]pyridazinyl, thieno[2,3-d]imidazolyl, thieno[2,3-d]imidazolyl, pyrazolo[3,4-c]pyridinyl, benzothiazolyl, benzimidazolyl, benzoxazolyl, benzothienyl, quinolyl, isoquinolyl, benzofuranyl, indolizinyl, quinoxalinyl, indazolyl, pyrrolopyrimidinyl, furopyridinyl, isoindolyl;

[0079] Preferably, R5 is selected from optionally substituted 4-15 membered heteroaryl, optionally substituted 6-10 membered aryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium, deuterated C1-C6 alkoxy, -NRd1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), optionally substituted 4-7 membered heterocyclic group containing 1-2 heteroatoms selected from N, O or S; the 4-15 membered heteroaryl group is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, furan ring group, thiophene ring group, oxazolyl group, thiazolyl group, isoxazolyl group, isothiazolyl group, pyridine ring group, pyrimidine ring group, triazinyl group (e.g., 1,2,3-triazinyl group, 1,2,4-triazinyl group, 1,3,5-triazinyl group), pyranyl group, thiopyranyl group;

[0080] More preferably, R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl;

[0081] More preferably, R5 is selected from any one of the groups (1) to (7):

[0082] (1) Preferred Wherein, W1 and W2 are each independently selected from C or N, R m Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1each independently selected from optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is an optionally substituted C1-C6 alkyl, an optionally substituted C2-C8 alkenyl, an optionally substituted C2-C8 alkynyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 alkyloxy, an optionally substituted hydroxyC1-C6 alkyl, or an optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 ring atoms selected from N, O or S, and optionally Substituted C1-C6 alkylcarbonyl; the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; the "optionally substituted" means preferably substituted by C1-C6 alkyl, the "optionally substituted" means preferably substituted by methyl; Preferably selected from:

[0083] (2) unsubstituted or optionally substituted by R m 、R nA substituted 5-membered heteroaryl group, wherein the 5-membered heteroaryl ring group contains 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; the 5-membered heteroaryl ring group is more preferably selected from: furan ring group, thiophene ring group, pyrrole ring group; the 5-membered heteroaryl ring group is even more preferably selected from: as well as (Preferred )(where R m 、R n independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NRa1'Rb1', wherein Ra1', Rb1' are optionally substituted C1-C6 alkyl, optionally substituted amino (-NRa1'Rb1', wherein Ra1', Rb1' are optionally substituted C1-C6 alkyl, optionally substituted amino (-NRa1' d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, the “optionally substituted "Optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium, substituted; the "optionally substituted" means preferably selected from C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, and the "optionally substituted" means more preferably substituted by trifluoromethyl or methyl; preferably, for );

[0084] (3) (Preferred ), where R m 、R n Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where Rd2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl or deuterium; preferably, R m and R n Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m and R n Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0085] Even more preferably, R5 is selected from Among them, R m1 、R n1 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl; the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 and R n1 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m1 and R n1Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0086] Alternatively, R5 is selected from Among them, R m2 、R n2 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl or deuterium; preferably, R m2 、R n2 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m2 、R n2 Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0087] or,

[0088] R5 is selected from Among them, R m3 、R n3 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl or deuterium; preferably, R m3 、R n3 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m3 、R n3 Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0089] (4) unsubstituted or optionally substituted by Rm 、R n substituted 1,2,4-triazole ring group, 1,2,3-triazole ring group, 1,2,4-oxadiazole ring group or isoxazole ring group, R m 、R n Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl or deuterium; preferably, R m and R n Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m and R n Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0090] More preferably, R5 is selected from Among them, R m1 、R n1 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl or deuterium; preferably, R m1 、R n1 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m1 、R n1 Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0091] or,

[0092] R5 is selected from Among them, R m2 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m2 is selected from: hydrogen, C1-C6 alkyl; More preferably, R m2 Selected from: hydrogen, methyl; or

[0093] R5 is selected from Among them, R m3 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl; the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 is selected from: hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms; more preferably, R m3 Selected from: hydrogen, trifluoromethyl;

[0094] R5 is selected from Among them, R m4 、R n4 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl or deuterium; preferably, R m4 、R n4Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m4 、R n4 Each independently selected from: hydrogen, trifluoromethyl;

[0095] (5) or a 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, preferably

[0096] (6) Preferred R m 、R n Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl; the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R nis selected from the group consisting of: hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m 、R n Selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0097] Preferably, Among them, R m1 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m is selected from: hydrogen, a 4-7 membered heterocyclic group containing 1-2 heteroatoms selected from N atoms, O atoms, and S atoms as ring atoms, a C1-C6 alkoxy group, a C3-C8 cycloalkoxy group, an amino group which is unsubstituted or optionally substituted with 1-2 C1-C6 alkyl groups; more preferably, R mSelected from: hydrogen, morpholinyl, methoxy, cyclopropyloxy, dimethylamino; or

[0098] Among them, R m2 、R n2 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m2、 R n2 Each is independently selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms; more preferably, R m2 、R n2 Each independently selected from: hydrogen, methoxy, trifluoromethyl, methyl;

[0099] (7) (Preferred ), where R m Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium substitution; preferably selected from: hydrogen, C3-C8 cycloalkoxy, C1-C6 alkyl; more preferably selected from: hydrogen, cyclopropyloxy, methyl;

[0100] More preferably, R5 is selected from any one of the groups (i) to (iii):

[0101] (i) (Preferred ), where R m 、R n Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Each is independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0102] Even more preferably, R5 is selected from R m1 、R n1 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0103] Even more preferably, R5 is selected from Among them, R m3 、R n3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl;

[0104] (ii) Preferred R m 、R n Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R nEach is independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Each is independently selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, deuterated methoxy, -NHCD3;

[0105] (iii) (Preferred ), where R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, deuterated methoxy, -NHCD3;

[0106] X5 is selected from the group consisting of: direct bond, -NH-, -O-, -S-, -C(O)-, -S(O)2-, -S(O)-, -N(Rq )-、 where R q is selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, optionally substituted C1-C6 acyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium, preferably, R q is selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably, R q Selected from: methyl, ethyl, n-propyl or isopropyl;

[0107] Preferably, X5 is selected from: -NH-, -C(O)-, -S(O)2-, -S(O)-, -N(R q )-、 where R q is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl;

[0108] More preferably, X5 is selected from the group consisting of: direct bond, -NH-, -N(CH3)-, -O-, -S-, -C(O)-, -S(O)2-, -S(O)-,

[0109] Most preferably, X5 is selected from -NH-, -N(CH3)-, -N(C(O)CH3)-;

[0110] n1 is selected from 0, 1, 2, 3, 4, preferably 0, 1, and most preferably 0; n2 is selected from 0, 1, 2, 3, 4, preferably 0, 1, 2, and most preferably 1; and when one of them is 0, the other is not 0; when one is not 0, the other is 0; most preferably, n1 is 0 and n2 is 1;

[0111] R 61 、R 62 、R 71 、R 72 , when present, are each independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; more preferably, R 61 、R 62 、R 71 、R 72Each independently selected from: hydrogen, methyl, ethyl, or, R 61 With R 71 or R 62 With R 72 Together form a C3-C8 cycloalkylene group or =O, preferably, R 61 With R 71 or R 62 With R 72 Together =O;

[0112] The above-mentioned compound satisfies the following conditions:

[0113] When R8 is methyl, R1 is not

[0114] When R8 is -NR d1 R e1 When R1 is not

[0115] When R8 is -NH2, -COOH, -C(=O)O-C2H5, -CH2-NH2, -CN, When R1 is not and the compound is not:

[0116] Embodiment 2: For the above embodiment 1, wherein,

[0117] When R8, R9 are each independently selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where Rs2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl), X5 is selected from: -C(O)-, -S(O)2-, -S(O)-, where R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl; or

[0118] When R8, R9 are each independently selected from: optionally substituted C1-C6 alkylcarbonyl, (where X6 is O, S or NR x Where N is the attachment site, R z is an optionally substituted C1-C6 alkyl group, R x is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkylsulfinyl (-S(O)R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkylsulfonyl (-S(O)2R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted di(C1-C6 alkyl)phosphinyl ( where R g 、R h is an optionally substituted C1-C6 alkyl), halogen, or nitro group, X5 is selected from: -NH-, -N(R q )-, where R qSelected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl.

[0119] Embodiment 3: With respect to the above embodiment 1, wherein the structural formula of the compound is selected from the following:

[0120] 1)

[0121] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0122] 2)

[0123] Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0124] Preferably, wherein: R1 is selected from a 5-7 membered heteroaromatic ring group, preferably a 5-6 membered heteroaromatic ring group, more preferably a 6 membered heteroaromatic ring group, wherein the above heteroaromatic ring group contains 1-2 heteroatoms, wherein the heteroatoms are selected from N atoms, O atoms, S atoms (preferably N atoms); wherein the heteroaromatic ring group is optionally substituted by R a 、R b 、R c replaced by;

[0125] Further preferably, R1 is selected from a pyrimidine ring group, wherein the pyrimidine ring group is optionally substituted by a group R a 、R b 、R c replaced by;

[0126] Even more preferably, R1 is selected from: Among them, R a 、R b 、Rc Independently selected from: hydrogen, C1-C6 alkoxy, C3-C8 cycloalkyl; preferably selected from: hydrogen, methoxy, cyclopropyl;

[0127] R3 is selected from: hydrogen, C1-C6 alkyl; preferably selected from: hydrogen;

[0128] R2 is selected from: hydrogen, C1-C6 alkyl; preferably selected from: hydrogen;

[0129] R8 is selected from: C1-C6 acyl, di(C1-C6 alkyl)phosphinyl, which is unsubstituted or optionally substituted by 1-9 halogen atoms; preferably selected from: acetyl, trifluoroacetyl, dimethylphosphinyl;

[0130] Alternatively, R2, R8 together with the atoms to which they are attached form Wherein, * indicates the atomic position to which R2 and R8 are connected respectively;

[0131] Ring B is selected from 6-10 membered aryl, 7-14 membered bicyclic or tricyclic fused heterocyclic group, preferably 6 membered aryl, 7-9 membered bicyclic fused heterocyclic group, wherein the aryl or fused heterocyclic group is optionally substituted by R 41 、R 42 , replaced by R5;

[0132] Even more preferably, Ring B is selected from

[0133] R 41 、R 42 Selected from: hydrogen, C1-C6 alkyl; preferably selected from: hydrogen;

[0134] R5 is selected from: Among them, R m 、R n Each is independently selected from: C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms; preferably selected from: trifluoromethyl, isopropyl;

[0135] X5 is selected from: -NH-;

[0136] n1 is selected from 0, 1, 2, 3, 4, preferably 0, 1, more preferably 0; n2 is selected from 0, 1, 2, 3, 4, preferably 0, 1, 2, more preferably 1; and when one of them is 0, the other is not 0; when one is not 0, the other is 0;

[0137] R 61 、R 71 、R 62 、R 72 , when present, are each independently selected from: hydrogen, C1-C6 alkyl, preferably selected from: hydrogen, or, R 61 With R 71 or R62 With R 72 Together they form a C3-C8 cycloalkylene subunit, preferably

[0138] 3)

[0139] Among them: R1, R2, R8, R9, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0140] 4)

[0141] Among them: R1, R2, R3, R8, R9, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0142] 5)

[0143] Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0144] 6)

[0145] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0146] 7)

[0147] Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0148] 8)

[0149] Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0150] 9)

[0151] Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0152] 10)

[0153] Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0154] 11)

[0155] Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0156] 12)

[0157] Among them: R1, R2, R8, B ring, R 41 、R 42、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0158] 13)

[0159] Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0160] 14)

[0161] Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0162] 15)

[0163] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0164] 16)

[0165] Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0166] 17)

[0167] Among them: R1, R2, R8, B ring, R 41 、R42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2,

[0168] Preferably, wherein:

[0169] R1 is selected from a 5-7 membered heteroaromatic ring group, preferably a 5-6 membered heteroaromatic ring group, more preferably a 6 membered heteroaromatic ring group, wherein the above heteroaromatic ring group contains 1-2 heteroatoms, and the heteroatoms are selected from N atoms, O atoms, S atoms (preferably N atoms); the heteroaromatic ring group is optionally substituted by R a 、R b 、R c replaced by;

[0170] Further preferably, R1 is selected from a pyrimidine ring group, wherein the pyrimidine ring group is optionally substituted by a group R a 、R b 、R c replaced by;

[0171] Even more preferably, R1 is selected from: Among them, R a 、R b 、R c Independently selected from: hydrogen, C1-C6 alkoxy, C3-C8 cycloalkyl; preferably selected from: hydrogen, methoxy, cyclopropyl;

[0172] R3 is selected from: hydrogen, C1-C6 alkyl; preferably selected from: hydrogen, methyl;

[0173] R2 is selected from: hydrogen, C1-C6 alkyl, C1-C6 acyl; preferably selected from: hydrogen, methyl, ethyl, acetyl;

[0174] R8 is selected from: C1-C6 amide, C1-C6 acyl, C1-C6 alkyl; preferably selected from: amide, acetyl, ethyl;

[0175] Alternatively, R2, R8 together with the atoms to which they are attached form Wherein, * indicates the atomic position to which R2 and R8 are connected respectively;

[0176] Ring B is selected from 6-10 membered aryl groups, preferably 6 membered aryl groups, which are optionally substituted by R 41 、R 42 , replaced by R5;

[0177] Even more preferably, Ring B is selected from

[0178] R 41 、R42 Each is independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen; preferably, R 41 、R 42 Each independently selected from: hydrogen; fluorine, methoxy;

[0179] R5 is selected from: Among them, R m 、R n Each is independently selected from: C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms; preferably selected from: trifluoromethyl, isopropyl, methyl, ethyl;

[0180] X5 is selected from: -NH-;

[0181] n1 is selected from 0, 1, 2, 3, 4, preferably 0, 1, more preferably 0; n2 is selected from 0, 1, 2, 3, 4, preferably 0, 1, 2, more preferably 1; and when one of them is 0, the other is not 0; when one is not 0, the other is 0;

[0182] R 61 、R 62 、R 71 、R 72 , when present, are each independently selected from: hydrogen, C1-C6 alkyl, preferably selected from: hydrogen;

[0183] 18)

[0184] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0185] 19)

[0186] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0187] 20)

[0188] Among them: Ring A, R1, R2, R3, R8, R9, R 41、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0189] twenty one)

[0190] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0191] twenty two)

[0192] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0193] twenty three)

[0194] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0195] twenty four)

[0196] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0197] 25)

[0198] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0199] 26)

[0200] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0201] 27)

[0202] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0203] 28)

[0204] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0205] 29)

[0206] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0207] 30)

[0208] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0209] 31)

[0210] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0211] 32)

[0212] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0213] 33)

[0214] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0215] 34)

[0216] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72As defined in any one of embodiments 1 and 2;

[0217] 35)

[0218] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0219] 36)

[0220] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0221] 37)

[0222] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0223] 38)

[0224] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0225] 39)

[0226] Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0227] 40)

[0228] Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0229] 41)

[0230] Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0231] 42)

[0232] Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0233] 43)

[0234] Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0235] 44)

[0236] Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0237] 45)

[0238] Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0239] 46)

[0240] Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0241] R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl;

[0242] 47)

[0243] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0244] 48)

[0245] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0246] 49)

[0247] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0248] 50)

[0249] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0250] 51)

[0251] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0252] 52)

[0253] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0254] 53)

[0255] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0256] 54)

[0257] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0258] 55)

[0259] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0260] 56)

[0261] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0262] 57)

[0263] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0264] 58)

[0265] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0266] 59)

[0267] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0268] 60)

[0269] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0270] 61)

[0271] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0272] 62)

[0273] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0274] 63)

[0275] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0276] 64)

[0277] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0278] 65)

[0279] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0280] 66)

[0281] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0282] 67)

[0283] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0284] 68)

[0285] Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0286] 69)

[0287] Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0288] 70)

[0289] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0290] 71)

[0291] Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0292] 72)

[0293] Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0294] 73)

[0295] Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0296] 74)

[0297] Among them: R1, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0298] 75)

[0299] Among them: R1, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0300] 76)

[0301] Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0302] 77)

[0303] Among them: R1, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0304] 78)

[0305] Where: R1, R41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0306] 79)

[0307] Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0308] 80)

[0309] Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0310] 81)

[0311] Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0312] 82)

[0313] Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0314] 83)

[0315] Where: R1, R 41 、R 42 、R5、X5、n1、n2、R61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0316] 84)

[0317] Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0318] 85)

[0319] Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0320] 86)

[0321] Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0322] 87)

[0323] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0324] 88)

[0325] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R62 、R 72 As defined in any one of embodiments 1 and 2;

[0326] 89)

[0327] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0328] 90)

[0329] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0330] 91)

[0331] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0332] 92)

[0333] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0334] 93)

[0335] Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62、R 72 As defined in any one of embodiments 1 and 2;

[0336] R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl;

[0337] 94)

[0338] Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0339] 95)

[0340] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0341] 96)

[0342] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0343] 97)

[0344] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0345] 98)

[0346] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0347] 99)

[0348] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0349] 100)

[0350] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0351] 101)

[0352] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0353] 102)

[0354] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0355] 103)

[0356] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0357] 104)

[0358] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0359] 105)

[0360] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0361] 106)

[0362] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0363] 107)

[0364] Among them: Ring A, R1, R2, R3, R8, R9, R41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0365] 108)

[0366] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0367] 109)

[0368] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0369] 110)

[0370] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0371] 111)

[0372] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0373] 112)

[0374] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0375] 113)

[0376] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0377] 114)

[0378] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0379] 115)

[0380] Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0381] 116)

[0382] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0383] 117)

[0384] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0385] 118)

[0386] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0387] 119)

[0388] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0389] 120)

[0390] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0391] 121)

[0392] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0393] 122)

[0394] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0395] 123)

[0396] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0397] 124)

[0398] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0399] 125)

[0400] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0401] 126)

[0402] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0403] 127)

[0404] Among them: R1, R2, R8, R41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0405] 128)

[0406] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0407] 129)

[0408] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0409] 130)

[0410] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0411] 131)

[0412] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0413] 132)

[0414] Among them: R1, R2, R8, R 41 、R42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0415] 133)

[0416] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0417] 134)

[0418] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0419] 135)

[0420] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0421] 136)

[0422] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0423] 137)

[0424] Among them: R1, R2, R8, R 41 、R 42、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0425] 138)

[0426] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0427] 139)

[0428] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0429] 140)

[0430] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0431] R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl;

[0432] 141)

[0433] Among them: R1, R2, R3, R8, R 41 、R 42、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0434] 142)

[0435] Among them: R1, R2, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0436] 143)

[0437] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0438] 144)

[0439] Among them: R1, R2, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0440] 145)

[0441] Among them: R1, R2, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0442] 146)

[0443] Among them: R1, R2, R3, R8, R 41 、R 42、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0444] 147)

[0445] Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0446] 148)

[0447] Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0448] 149)

[0449] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0450] 150)

[0451] Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0452] 151)

[0453] Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0454] 152)

[0455] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0456] 153)

[0457] Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2;

[0458] 154)

[0459] Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2.

[0460] Embodiment 4: For any one of the above embodiments 1 to 3, wherein:

[0461] R1 is selected from: in,

[0462] R on R1 a 、R b 、R c entirely hydrogen; or

[0463] R on R1 c is hydrogen, in which case R1 has R a 、R b Two substituents; R a 、R bIndependently selected from: C1-C6 alkyl optionally substituted by 5-6-membered aromatic ring group, 5-6-membered heteroaromatic ring group, 5-6-membered saturated or partially unsaturated heterocyclic group, C3-C8 cycloalkyl group, C1-6 alkoxy optionally substituted by 5-6-membered aromatic ring group, 5-6-membered heteroaromatic ring group, 5-6-membered saturated or partially unsaturated heterocyclic group, C3-C8 cycloalkyl group, C1-C6 alkoxy optionally substituted by C1-C6 alkoxy group or one or more halogens.

[0464] Implementation 5: For the above implementation 3,

[0465] For 1) Formula I-A1, 18) Formula I-B1, 19) Formula I-B2, 20) Formula I-B3, 21) Formula I-B4, 22) Formula I-B5, 23) Formula I-B6, 24) Formula I-B7, 25) Formula I-B8, 26) Formula I-B9, 27) Formula I-B10, 28) Formula I-B11, 29) Formula I-B12, 30) Formula I-B13, 31) Formula I-B14, 32) Formula I-B15, 33) Formula I-B16, 34) Formula I-B17, 35) Formula I-B18, 36) Formula I-B19, 37) Formula I-B19-2, 38) Formula I-B19-3, 39) Formula I-X1, 40) Formula I-X2, 41) Formula I-X3, 42) Formula I-X 4, 43) Formula I-X5, 44) Formula I-X6, 45) Formula I-X7, 46) Formula I-X8, 47) Formula I-AB1, 48) Formula I-AB2, 49) Formula I-AB3, 50) Formula I-AB4, 51) Formula I-AB5, 52) Formula I-AB6, 53) Formula I-AB7, 54) Formula I-AB8, 55) Formula I-AB9, 56) Formula I-AB10, 57) Formula I-AB11, 58) Formula I-AB12, 59) Formula I-AB13, 60) Formula I-AB14, 61) Formula I-AB15, 62) Formula I-AB16, 63) Formula I-AB17, 64) Formula I-AB18, 65) Formula I-AB19, 66) Formula I-AB19- 2, 67) Formula I-AB19-3, 87) Formula I-AX1, 88) Formula I-AX2, 89) Formula I-AX3, 90) Formula I-AX4, 91) Formula I-AX5, 92) Formula I-AX6, 93) Formula I-AX7, 94) Formula I-AX8, 95) Formula I-BX1, 96) Formula I-BX2, 97) Formula I-BX3, 98) Formula I-BX4, 99) Formula I-BX5, 100) Formula I-BX6, 101) Formula I-BX7, 102) Formula I-BX8, 103) Formula I-BX9, 104) Formula I-BX10, 105) Formula I-BX11, 106) Formula I-BX12, 107) Formula I-BX13, 108) Formula I-BX14, 109) Formula I-BX15, 110) Formula I-BX16, 111) Formula I-BX17, 112) Formula I-BX18, 113) Formula I-BX19, 114) Formula I-BX19-2, 115) Formula I-BX19-3, 116) Formula I-ABX1, 117) Formula I-ABX2, 118) Formula I-ABX3, 119) Formula I-ABX4, 120) Formula I-ABX5, 121) Formula I-ABX6, 122) Formula I-ABX7, 123) Formula I-ABX7-2, 124) Formula I-ABX7-3, 125) Formula I-ABX8, 126) Formula I-ABX9, 127) Formula I-ABX10, 128) Formula I-ABX11,129) Formula I-ABX12, 130) Formula I-ABX13, 131) Formula I-ABX14, 132) Formula I-ABX15, 133) Formula I-ABX16, 134) Formula I-ABX17, 135) Formula I-ABX18, 136) Formula I-ABX19, 137) Formula I-ABX20, 138) Formula I-ABX21, 139) Formula I-ABX22, 140) Formula I-ABX23, wherein:

[0466] R2 is selected from: C1-C6 alkyl, halogen, cyano;

[0467] R8 is selected from: optionally substituted C1-C6 alkyl, (where X6 is O, S or NR x Where N is the attachment site, R z is an optionally substituted C1-C6 alkyl group, R x is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 alkylsulfinyl (-S(O)R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkylsulfonyl (-S(O)2R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted di(C1-C6 alkyl)phosphinyl ( where R g 、R h is an optionally substituted C1-C6 alkyl group).

[0468] Embodiment 6: For any one of the above embodiments 1-3, wherein:

[0469] X5 is a direct key;

[0470] Ring B is a 5-6 membered aromatic ring group or a 5-6 membered heteroaromatic ring group, wherein the 5-6 membered aromatic ring group or the 5-6 membered heteroaromatic ring group is optionally substituted by 1-2 substituents selected from the group consisting of hydrogen, halogen, and alkoxy;

[0471] R5 is a 5-6 membered heteroaryl group, which is optionally substituted by 2-3 substituents selected from the group consisting of hydrogen, cyano, halogen, C1-C6 alkyl optionally substituted by halogen, C3-C8 cycloalkyl, and 4-15 membered heterocyclyl.

[0472] Embodiment 7: For the above embodiment 1, wherein the compound has the structural formula of formula I-ABX44,

[0473] in:

[0474] Q1 is CH or N, Q2 is CH or N, provided that at least one of Q1 and Q2 is N; preferably, Q1 is N, and Q2 is N or CH;

[0475] R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl; preferably, R 10 is H, C1-C4 alkyl or -C(O)-C1-C4 alkyl; preferably, R 10 is H, methyl, ethyl, -C(O)-methyl; more preferably, R 10 is H or methyl;

[0476] Ring B is selected from phenyl, 6-membered heteroaryl, 7-10-membered bridged heterocyclic group, wherein the 6-membered heteroaryl, 7-10-membered bridged heterocyclic group contains 1-2 N atoms; preferably, Ring B is selected from wherein Q3, Q4, Q5, and Q6 are each independently selected from CH or N, and t is 1 or 2; preferably, Selected from wherein Q3, Q4, Q5, and Q6 are each independently selected from CH or N, preferably, at most one of Q3, Q4, Q5, and Q6 is N, and t is 1 or 2;

[0477] R1, R2, R8, R 41 、R 42 、R5、n2、R 62 、R 72 As defined in any one of embodiments 1 and 2; preferably,

[0478] R1 is selected from: Among them, R a 、R b 、R cindependently selected from: hydrogen, halogen, cyano, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), said C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted with one or more halogen, deuterium or C1-C6 alkyloxy; a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuterium or C1-4 alkyloxy groups; a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen or C1-C4 alkyl), wherein the C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy is optionally substituted with one or more deuterium or C1-4 alkyloxy groups; a 、R b 、R cFurther preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, methoxy, difluoromethoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a 、R b 、R c More preferably, it is selected from the group consisting of hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3;

[0479] R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkyloxy, and C1-C6 haloalkyl; preferably selected from the group consisting of hydrogen, C1-C6 alkyl, and halogen; preferably selected from the group consisting of hydrogen, C1-C4 alkyl, and halogen; more preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; further preferably selected from the group consisting of hydrogen;

[0480] R8 is selected from: halogen, C1-C6 alkyl, C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl or C3-C8 halocycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 each independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R his C1-C6 alkyl); preferably selected from: R8 is selected from: halogen, C1-C6 alkyl, -NR d1 R e1 (where R d1 、R e1 Each independently selected from H, C1-C6 alkyl, C3-C8 cycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 and the nitrogen atom to which it is attached form a 4-7 membered heterocyclic group); preferably selected from: C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl or C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-6 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Each is independently selected from the group consisting of -C(O)-R s1 (where R s1C1-C4 alkyl, C1-C4 haloalkyl, C3-C5 cycloalkyl, C3-C4 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C4 alkyl, C3-C5 cycloalkyl, deuterated C1-C4 alkyl, or R d3 、R e3 Each is independently selected from the group consisting of a 4-5 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, More preferably selected from: acetyl,

[0481] Alternatively, R2, R8 or R2, R9 together with the atoms to which they are attached form Wherein, * represents the position of the atom to which R2, R8 or R2, R9 are connected; preferably, R2, R8 or R2, R9 together with the atoms to which they are connected form Where * indicates the position of the atom to which R2, R8 or R2, R9 are respectively connected;

[0482] n2 is 1;

[0483] R 62 、R 72 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; more preferably selected from: hydrogen, methyl, ethyl, or R 62 With R 72 Together form a C3-C8 cycloalkylene group (preferably a C3-C5 cycloalkylene group) or =O, preferably

[0484] R 41 and R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; preferably selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxy; preferably selected from: hydrogen, C1-C4 alkoxy, C1-C4 alkyl, halogen, hydroxy; more preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen;

[0485] R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, deuterated C1-C6 alkyl, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; the 5-6 membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, pyridine ring group, pyrimidine ring group;

[0486] Preferably, R5 is selected from an optionally substituted 5-membered heteroaryl group, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyloxy, hydroxyl, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl or deuterated C1-C6 alkyl); the 5-membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group;

[0487] Further preferably, R5 is selected from an optionally substituted 5-membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more C1-C4 alkyl, deuterated C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkyloxy, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C4 alkyl or deuterated C1-C4 alkyl); the 5-membered heteroaryl is preferably selected from: pyrazole ring group, imidazole ring group;

[0488] More preferably, R5 is selected from:

[0489] (i) (Preferred ), where R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m 、R n Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; More preferably, R m 、R n is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m 、R nSelected from: methyl, trideuteromethyl, isopropyl, trifluoromethyl, CH2CF3, methoxy, trideuteromethoxy, -NHCD3;

[0490] Even more preferably, R5 is selected from: R m1 、R n1 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m1 、R n1 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m1 、R n1is selected from the group consisting of: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3; further preferably, R m1 、R n1 Selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3;

[0491] Even more preferably, R5 is selected from: Among them, R m3 、R n3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m3 、R n3 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, Rm3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; further preferably, R m3 、R n3 Selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl;

[0492] (ii) Preferred R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3;

[0493] (iii) (Preferred ), where R mSelected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3;

[0494] More preferably, R5 is selected from:

[0495] R m1 、R n1 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m1 、R n1 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 Re1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m1 、R n1 is selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, deuterated methoxy, -NHCD3; further more preferably, R m1 、R n1 is selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3; further more preferably, R m1 Selected from: methyl, methoxy, trideuterated methoxy, -NHCD3, R n1 is trifluoromethyl;

[0496] or Among them, R m3 、R n3 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m3 、R n3 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, deuterated methyl, deuterated methoxy, -NHCD3; further more preferably, R m3 、R n3 is selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; further more preferably, R m3 Selected from: isopropyl, CH2CF3, trideuterated methyl, R n3 It is trifluoromethyl.

[0497] Embodiment 8: For the above embodiment 1, wherein the structural formula of the compound is formula I-ABX39,

[0498] in:

[0499] Q1 is CH or N, Q2 is CH or N, provided that at least one of Q1 and Q2 is N; Q3, Q4, Q5, Q6 are each independently selected from CH or N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl;

[0500] R1, R2, R8, R 41 、R 42 、R5、n2、R 62 、R 72 As defined in any one of embodiments 1 and 2.

[0501] Embodiment 9: For the above embodiment 8, wherein the compound has the structural formula of formula I-ABX40,

[0502] in:

[0503] Q1 is CH or N, Q2 is CH or N, provided that at least one of Q1 and Q2 is N; Q3, Q4, Q5, Q6 are each independently selected from CH or N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl;

[0504] R1 is selected from: Among them, R a 、R b 、R c independently selected from: hydrogen, halogen, cyano, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), said C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted with one or more halogen, deuterium or C1-C6 alkyloxy; a 、R b 、R cPreferably selected from H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuterium or C1-4 alkyloxy groups; a 、R b 、R c Further preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, methoxy, difluoromethoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a 、R b 、R c More preferably, it is selected from the group consisting of hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3;

[0505] R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkyloxy, and C1-C6 haloalkyl; preferably selected from the group consisting of hydrogen, C1-C6 alkyl, and halogen; more preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; further preferably selected from the group consisting of hydrogen;

[0506] R8 is selected from: halogen, C1-C6 alkyl, C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl or C3-C8 halocycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 each independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from: C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl or C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-6 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Each is independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, More preferably selected from: acetyl,

[0507] Alternatively, R2, R8 or R2, R9 together with the atoms to which they are attached form Wherein, * represents the position of the atom to which R2, R8 or R2, R9 are connected; preferably, R2, R8 or R2, R9 together with the atoms to which they are connected form Where * indicates the position of the atom to which R2, R8 or R2, R9 are respectively connected;

[0508] R 62 、R 72 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; more preferably selected from: hydrogen, methyl, ethyl, or R 62 With R 72 Together form a C3-C8 cycloalkylene group or =O, preferably

[0509] R 41 and R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; preferably selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxy; more preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen;

[0510] R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, deuterated C1-C6 alkyl, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; the 5-6 membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, pyridine ring group, pyrimidine ring group;

[0511] More preferably, R5 is selected from:

[0512] (i) (Preferred ), where R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m 、R n Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m、R n Selected from: methyl, trideuteromethyl, isopropyl, trifluoromethyl, CH2CF3, methoxy, trideuteromethoxy, -NHCD3;

[0513] Even more preferably, R5 is selected from: R m1 、R n1 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m1 、R n1 is selected from the group consisting of: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3; further preferably, R m1 、R n1 Selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3;

[0514] Even more preferably, R5 is selected from: Among them, R m3 、R n3independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m3 、R n3 Selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl;

[0515] (ii) Preferred R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、Re1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3;

[0516] (iii) (Preferred ), where R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R mSelected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3.

[0517] Embodiment 10: With respect to the above embodiment 9, it has one or more selected from the following:

[0518] 1) R1 is selected from: Among them, R a 、R b 、R c independently selected from: H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuteriums; R a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen or C1-C4 alkyl), wherein the C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy is optionally substituted with one or more deuteriums; R a 、R b 、R cMore preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R c More preferably, it is selected from the group consisting of hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3;

[0519] More preferably, R1 is selected from:

[0520] Among them, R a Selected from: C1-C4 alkyl, C3-C5 cycloalkyl, R b Selected from: hydrogen, R c is selected from: C1-C4 alkyloxy, wherein the C1-C4 alkyloxy is optionally substituted by one or more deuteriums; preferably, R a Selected from: methyl, cyclopropyl, R b Selected from: hydrogen, R c Selected from: methoxy, trideuterated methoxy;

[0521] or Among them, R a Selected from: hydrogen, R b Selected from: hydrogen, R c Selected from: C1-C4 alkyloxy; preferably, R a Selected from: hydrogen, R b Selected from: hydrogen, R c Selected from: methoxy;

[0522] or Among them, R a Selected from: hydrogen, cyano, C1-C4 alkyl, R b Selected from: hydrogen, R c Selected from: C1-C4 alkyloxy, C1-C4 alkyl; preferably, R a Selected from: hydrogen, methyl, cyano, R b Selected from: hydrogen, R c Selected from: methoxy, isopropyl;

[0523] or Among them, R a Selected from: hydrogen, C1-C4 haloalkyl, R b Selected from: hydrogen, R c Selected from: C1-C4 alkyl; preferably, R a Selected from: chlorine, trifluoromethyl, R b Selected from: hydrogen, R c Selected from: isopropyl;

[0524] or Among them, R a Selected from: hydrogen, C3-C5 cycloalkyl, R b Selected from: hydrogen, R c Selected from: C1-C4 alkyloxy, -C(O)NR d1 R e1 (where R d1 、R e1 are independently selected from hydrogen or C1-C4 alkyl); preferably, R a Selected from: chlorine, cyclopropyl, R b Selected from: hydrogen, R c Selected from: methoxy, -C(O)NHCH3;

[0525] Still further preferably, R1 is selected from

[0526] 2) R5 is selected from an optionally substituted 5-membered heteroaryl group, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyloxy, hydroxyl, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from optionally substituted H, C1-C6 alkyl or deuterated C1-C6 alkyl), the 5-membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group; preferably, R5 is selected from optionally substituted 5-membered heteroaryl, the "optionally substituted" means optionally substituted by one or more C1-C4 alkyl, deuterated C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkyloxy, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C4 alkyl or deuterated C1-C4 alkyl), the 5-membered heteroaryl is preferably selected from: pyrazole ring group, imidazole ring group; further preferably, R5 is selected from:

[0527] R m1 、R n1 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、Re1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m1 、R n1 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m1 、R n1 is selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, deuterated methoxy, -NHCD3; further more preferably, R m1 、R n1 is selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3; further more preferably, R m1 Selected from: methyl, methoxy, trideuterated methoxy, -NHCD3, R n1 is trifluoromethyl;

[0528] or Among them, R m3 、R n3 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m3 、R n3 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, deuterated methyl, deuterated methoxy, -NHCD3; further more preferably, R m3 、R n3 is selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; further more preferably, R m3Selected from: isopropyl, CH2CF3, trideuterated methyl, R n3 is trifluoromethyl;

[0529] Still more preferably, R5 is selected from:

[0530] Embodiment 11: For the above embodiment 8, 9 or 10, it has one or more selected from the following:

[0531] 1) Q1 is N, Q2 is N or CH;

[0532] 2) At most one of Q3, Q4, Q5, and Q6 is N;

[0533] 3) R 10 is H, C1-C4 alkyl or -C(O)-C1-C4 alkyl; preferably, R 10 is H, methyl, ethyl, -C(O)-methyl; more preferably, R 10 is H or methyl;

[0534] 4) R2 is selected from the group consisting of hydrogen, C1-C4 alkyl, and halogen; preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; and even more preferably H;

[0535] 5) R8 is selected from: halogen, C1-C6 alkyl, -NR d1 R e1 (where R d1 、R e1 Each independently selected from H, C1-C6 alkyl, C3-C8 cycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group); preferably selected from -C(O)-R s1 (where R s1 C1-C4 alkyl, C3-C5 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C4 alkyl, C3-C5 cycloalkyl, deuterated C1-C4 alkyl, or R d3 、Re3 Each independently selected from the group consisting of a 4-5 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, More preferably selected from: acetyl,

[0536] 6)R 62 、R 72 Independently selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy; preferably selected from: hydrogen, methyl, ethyl, methoxy; more preferably selected from: hydrogen, methyl, or R 62 With R 72 Together they form a C3-C5 cycloalkylene subunit, preferably

[0537] 7) R 41 and R 42 Each is independently selected from: hydrogen, C1-C4 alkoxy, C1-C4 alkyl, halogen, hydroxy; preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen.

[0538] Embodiment 12: For the above embodiment 1, wherein the structural formula of the compound is Formula I-ABX41,

[0539] in:

[0540] Q3, Q4, Q5, Q6 are each independently selected from CH or N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl;

[0541] R1, R8, R 41 、R 42 、R5、n2、R 62 、R 72 As defined in any one of embodiments 1 and 2.

[0542] Embodiment 13: For the above embodiment 12, wherein the compound has the structural formula of formula I-ABX42,

[0543] Wherein: Q3, Q4, Q5, Q6 are each independently selected from CH or N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl;

[0544] R1 is selected from: Among them, R a 、R b 、R cIndependently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), wherein the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted by one or more halogens; a 、R b 、R c R is preferably selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuterated methoxy, cyclopropyl, and difluorocyclopropyl; a 、R b 、R c More preferably, it is selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuterated methoxy;

[0545] R8 is selected from: halogen, C1-C6 alkyl, C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl or C3-C8 halocycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where Rf is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); R8 is preferably selected from: C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl or C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-6 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); R8 is more preferably selected from: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl,

[0546] R 62 、R 72 R is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, and amino; 62 、R 72 Preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; More preferably selected from: hydrogen, methyl, ethyl, or R 62 With R 72 Together form a C3-C8 cycloalkylene group or =O, preferably

[0547] R 41 and R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; preferably selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxy; more preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy;

[0548] R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; the 5-6 membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, pyridine ring group, pyrimidine ring group;

[0549] More preferably, R5 is selected from:

[0550] (i) (Preferred ), where R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where Rd1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3;

[0551] Even more preferably, R5 is selected from: R m1 、R n1 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m1 、R n1 Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3;

[0552] Even more preferably, R5 is selected from Among them, R m3 、Rn3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidine, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m3 、R n3 Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3;

[0553] (ii) Preferred R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3;

[0554] (iii) (Preferred ), where R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NRd1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3.

[0555] Embodiment 14: For the above embodiment 12 or 13, it has one or more selected from the following:

[0556] 1) At most one of Q3, Q4, Q5, and Q6 is N;

[0557] 2) R 10 is H or methyl;

[0558] 3) R8 is selected from: halogen, C1-C6 alkyl, -NR d1 R e1 (where R d1 、R e1 Each independently selected from H, C1-C6 alkyl, C3-C8 cycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group).

[0559] Embodiment 15: For the above embodiment 1, wherein the compound has the structural formula of Formula I-ABX43,

[0560] in:

[0561] Q1 is CH or N, Q2 is CH or N, provided that at least one of Q1 and Q2 is N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl, and t is 1 or 2;

[0562] R1, R2, R8, R 41 、R 42 、R5、n2、R62 、R 72 As defined in any one of embodiments 1 and 2;

[0563] Preferably, n2 is 1;

[0564] R1 is selected from: R1 is preferably Among them, R a 、R b 、R c independently selected from: hydrogen, halogen, cyano, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), wherein the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted by one or more halogen, deuterium or C1-6 alkyloxy; a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuterium or C1-4 alkyloxy groups; a 、R b 、R c Further preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R cMore preferably, R is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, methoxy, difluoromethoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a 、R b 、R c Still more preferably selected from: hydrogen, methoxy, cyclopropyl;

[0565] R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkyloxy, and C1-C6 haloalkyl; preferably selected from the group consisting of hydrogen, C1-C6 alkyl, and halogen; more preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; further preferably selected from the group consisting of hydrogen;

[0566] R8 is selected from: halogen, C1-C6 alkyl, C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl or C3-C8 halocycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 each independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from: C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl or C3-C6 cycloalkyl), -C(O)NR d3 Re3 (where R d3 、R e3 are independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-6 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Each is independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, More preferably selected from: acetyl, More preferably selected from: acetyl;

[0567] R 62 、R 72 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; more preferably selected from: hydrogen, methyl, ethyl, or R 62 With R 72 Together form a C3-C8 cycloalkylene group or =O, preferably

[0568] R 41 and R 42Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; preferably selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxy; more preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen;

[0569] R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, deuterated C1-C6 alkyl, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; the 5-6 membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, pyridine ring group, pyrimidine ring group;

[0570] More preferably, R5 is selected from:

[0571] (i) (Preferred ), where R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m 、R n Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m 、R n Selected from: methyl, trideuteromethyl, isopropyl, trifluoromethyl, CH2CF3, methoxy, trideuteromethoxy, -NHCD3;

[0572] Even more preferably, R5 is selected from: R m1 、R n1independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m1 、R n1 is selected from the group consisting of: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3; further preferably, R m1 、R n1 Selected from: methyl, trifluoromethyl, methoxy, deuterated methoxy, -NHCD3;

[0573] Even more preferably, R5 is selected from: Among them, R m3 、R n3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m3 、R n3 is selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; further more preferably, R m3 、R n3 Selected from: trifluoromethyl, isopropyl;

[0574] (ii) Preferred R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3;

[0575] (iii) (Preferred ), where R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NRd1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3.

[0576] Embodiment 16: With respect to the above embodiment 15, it has one or more selected from the following:

[0577] 1) R1 is selected from: Among them, R a 、R b 、R c independently selected from: H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuteriums; R a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen or C1-C4 alkyl), wherein the C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy is optionally substituted with one or more deuteriums; R a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、Rb 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a Preferably selected from: cyclopropyl, R b Preferably selected from: hydrogen, R c Preferably selected from: methoxy;

[0578] More preferably, R1 is selected from:

[0579] 2) R5 is selected from an optionally substituted 5-membered heteroaryl group, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyloxy, hydroxyl, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from optionally substituted H, C1-C6 alkyl or deuterated C1-C6 alkyl), the 5-membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group; preferably, R5 is selected from optionally substituted 5-membered heteroaryl, the "optionally substituted" means optionally substituted by one or more C1-C4 alkyl, deuterated C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkyloxy, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C4 alkyl or deuterated C1-C4 alkyl), the 5-membered heteroaryl is preferably selected from: pyrazole ring group, imidazole ring group; further preferably, R5 is selected from:

[0580] R m1 、R n1 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m1 、R n1 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 Re1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m1 、R n1 is selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, deuterated methoxy, -NHCD3; further more preferably, R m1 、R n1 is selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3; further more preferably, R m1 Selected from: methyl, methoxy, trideuterated methoxy, -NHCD3, R n1 is trifluoromethyl;

[0581] or Among them, R m3 、R n3 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m3 、R n3 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, deuterated methyl, deuterated methoxy, -NHCD3; further more preferably, R m3 、R n3 is selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; further more preferably, R m3 Selected from: isopropyl, CH2CF3, trideuterated methyl, R n3 is trifluoromethyl;

[0582] Still more preferably, R5 is selected from:

[0583] Embodiment 17: With respect to the above embodiment 15 or 16, it has one or more selected from the following:

[0584] 1) Q1 is N, Q2 is N or CH;

[0585] 2) R 10 is H, C1-C4 alkyl or -C(O)-C1-C4 alkyl; preferably, R 10 is H, methyl, ethyl, -C(O)-methyl; more preferably, R 10 is H or methyl;

[0586] 3) R2 is selected from the group consisting of hydrogen, C1-C4 alkyl, and halogen; preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; and even more preferably H;

[0587] 4) R8 is selected from: halogen, C1-C6 alkyl, -NR d1 R e1 (where R d1 、R e1 Each independently selected from H, C1-C6 alkyl, C3-C8 cycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group); preferably selected from -C(O)-R s1 (where R s1 C1-C4 alkyl, C3-C5 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C4 alkyl, C3-C5 cycloalkyl, deuterated C1-C4 alkyl, or R d3 、R e3 Each independently selected from the group consisting of a 4-5 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, More preferably selected from: acetyl,

[0588] 5)R 62 、R 72 Independently selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy; preferably selected from: hydrogen, methyl, ethyl, methoxy; more preferably selected from: hydrogen, methyl, or R 62 With R72 Together they form a C3-C5 cycloalkylene subunit, preferably

[0589] 6)R 41 and R 42 Each is independently selected from: hydrogen, C1-C4 alkoxy, C1-C4 alkyl, halogen, hydroxy; preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen;

[0590] 7)n is 1.

[0591] Embodiment 18: For any one of the above embodiments 1-17, wherein the compound is selected from the compounds shown below:

[0592] Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6, Compound 7, Compound 8, Compound 9, Compound 10, Compound 11, Compound 12, Compound 13, Compound 14, Compound 15, Compound 16, Compound 17, Compound 18, Compound 19, Compound 20, Compound 21, Compound 22, Compound 23, Compound 24, Compound 25, Compound 26, Compound 27, Compound 28, Compound 29, Compound 30, Compound 31, Compound 32, Compound 33, Compound 34, Compound 35, Compound 36, Compound 37, Compound 38, Compound 39, Compound 40, Compound 41, Compound 42, Compound 43, Compound 44, compound 45, compound 46, compound 47, compound 48, compound 49, compound 50, compound 51, compound 52, compound 53, compound 54, compound 55, compound 56, compound 57, compound 58, compound 59, compound 60, compound 61, compound 62, compound 63, compound 64, compound 65, compound 66, compound 67, compound 68, compound 69, compound 70, compound 71, compound 72, compound 73, compound 74, compound 75, compound 76, compound 77, compound 78, compound 79, compound 80, compound 81, compound 82, compound 83, compound 84, compound 85 5. Compound 86, Compound 87, Compound 88, Compound 89, Compound 90, Compound 91, Compound 92, Compound 93, Compound 94, Compound 95, Compound 96, Compound 97, Compound 98, Compound 99, Compound 100, Compound 101, Compound 102, Compound 103, Compound 104, Compound 105, Compound 106, Compound 107, Compound 108, Compound 109, Compound 110, Compound 111, Compound 112, Compound 113, Compound 114, Compound 115, Compound 116, Compound 117, Compound 118, Compound 119, Compound 120, Compound 121, Compound 122, Compound Compound 123, compound 124, compound 125, compound 126, compound 127, compound 128, compound 129, compound 130, compound 131, compound 132, compound 133, compound 134, compound 135, compound 136, compound 137, compound 138, compound 139, compound 140, compound 141, compound 142, compound 143, compound 144, compound 145, compound 146, compound 147, compound 148, compound 149, compound 150, compound 151, compound 152, compound 153, compound 154, compound 155, compound 156, compound 157, compound 158,Compound 159, Compound 160, Compound 161, Compound 162, Compound 163, Compound 164, Compound 165, Compound 166, Compound 167, Compound 168, Compound 169, Compound 170, Compound 171, Compound 172, Compound 173, Compound 174, Compound 175, Compound 176, Compound 177, Compound 178, Compound 179, Compound 180, Compound 181, Compound 182, Compound 183, Compound 184, Compound 185, Compound 186, Compound 187, Compound 188, Compound 189, Compound 190, Compound 191, Compound 192, Compound 193, Compound 194, Compound 195, Compound 196, Compound 197, Compound 198, Compound 199, Compound 200, Compound 201, Compound 202, Compound 203, Compound 204, Compound 205, Compound 206, Compound 207, Compound 208, Compound 209, Compound 210, Compound 211, Compound 212, Compound 213, Compound 214, Compound 215, Compound 216, Compound 217, Compound 218, Compound 219, Compound 220, Compound 221, Compound 222, Compound 223, Compound 224, Compound 225, Compound 226, Compound 227, Compound 228, Compound 229, Compound 230, Compound 231, Compound 232, Compound 233, Compound 234, Compound 235, Compound 236, Compound 237, Compound 238, Compound 239, Compound 240, Compound 241, Compound 242, Compound 243, Compound 244, Compound 245, Compound 246:

[0593] Preferably, the compound is selected from: Compound 1, Compound 2, Compound 3, Compound 4, Compound 6, Compound 7, Compound 9, Compound 12, Compound 13, Compound 14, Compound 15, Compound 16, Compound 17, Compound 18, Compound 48, Compound 49, Compound 50, Compound 51, Compound 109, Compound 112, Compound 116, Compound 119, Compound 120, Compound 155, Compound 156, Compound 157, Compound 158, Compound 174, Compound 198, Compound 199, Compound 206, Compound 207, Compound 208, Compound 236, Compound 237, Compound 239, Compound 240, Compound 241, Compound 242, Compound 243, Compound 244, Compound 245;

[0594] Further preferably, the compound is selected from compound 1, compound 2, compound 3, compound 4, compound 6, compound 7, compound 9, compound 12, compound 13, compound 14, compound 15, compound 16, compound 17, compound 18, compound 48, compound 49, compound 50, compound 51, compound 109, compound 112, compound 116, compound 119, compound 120, compound 155, compound 156, compound 157, compound 158, compound 198, compound 199, compound 206, compound 207, compound 208, compound 236, compound 237, compound 239, compound 240, and compound 241;

[0595] Or further preferably, the compound is selected from Compound 242, Compound 243, Compound 244, and Compound 245.

[0596] Embodiment 19: For any one of the above embodiments 1-17, wherein the compound is selected from:

[0597] 1) Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6, Compound 7, Compound 8, Compound 9, Compound 10, Compound 11, Compound 12, Compound 13, Compound 14, Compound 15, Compound 16, Compound 17, Compound 18, Compound 19, Compound 20, Compound 21, Compound 22, Compound 23, Compound 24, Compound 25, Compound 26, Compound 27, Compound 28, Compound 29, Compound 30, Compound 31, Compound 32, Compound 33, Compound 34, Compound 35, Compound 36, Compound 37, Compound 38, Compound 39, Compound 40, Compound 41, Compound 42, Compound 43 , compound 44, compound 45, compound 46, compound 47, compound 48, compound 49, compound 50, compound 51, compound 52, compound 53, compound 54, compound 55, compound 56, compound 57, compound 58, compound 59, compound 60, compound 61, compound 62, compound 63, compound 64, compound 65, compound 66, compound 67, compound 68, compound 69, compound 70, compound 71, compound 72, compound 73, compound 74, compound 75, compound 76, compound 77, compound 78, compound 79, compound 80, compound 81, compound 82, compound 83, compound 84, compound 85, compound 86, compound 87, compound 88, compound 89, compound 90, compound 91, compound 92, compound 93, compound 94, compound 95, compound 96, compound 97, compound 98, compound 99, compound 100, compound 101, compound 102, compound 103, compound 104, compound 105, compound 106, compound 107, compound 108, compound 109, compound 110, compound 111, compound 112, compound 113, compound 114, compound 115, compound 116, compound 117, compound 118, compound 119, compound 120, compound 121, compound 122, compound Compound 123, compound 124, compound 125, compound 126, compound 127, compound 128, compound 129, compound 130, compound 131, compound 132, compound 133, compound 134, compound 135, compound 136, compound 137, compound 138, compound 139, compound 140, compound 141, compound 142, compound 143, compound 144, compound 145, compound 146, compound 147, compound 148, compound 149, compound 150, compound 151, compound 152, compound 153, compound 154, compound 155, compound 156, compound 157, compound 158,Compound 159, Compound 160, Compound 161, Compound 162, Compound 163, Compound 164, Compound 165, Compound 166, Compound 167, Compound 168, Compound 169, Compound 170, Compound 171, Compound 172, Compound 173, Compound 174, Compound 175, Compound 176, Compound 177, Compound 178, Compound 179, Compound 180, Compound 181, Compound 182, Compound 183, Compound 184, Compound 185, Compound 186, Compound 187, Compound 188, Compound 189 9, compound 190, compound 191, compound 192, compound 193, preferably, the compound is selected from compound 1, compound 2, compound 3, compound 4, compound 6, compound 7, compound 9, compound 12, compound 13, compound 14, compound 15, compound 16, compound 17, compound 18, compound 48, compound 49, compound 50, compound 51, compound 109, compound 112, compound 116, compound 119, compound 120, compound 155, compound 156, compound 157, compound 158, compound 174; or,

[0598] 2) Compound 194, Compound 195, Compound 196, Compound 197, Compound 198, Compound 199, Compound 200, Compound 201, Compound 202, Compound 203, Compound 204, Compound 205, Compound 206, Compound 207, Compound 208, Compound 209, Compound 210, Compound 211, Compound 212, Compound 213, Compound 214, Compound 215, Compound 216, Compound 217, Compound 218, Compound 219, Compound 220, Compound 221, Compound 222, Compound 223 3. Compound 224, compound 225, compound 226, compound 227, compound 228, compound 229, compound 230, compound 231, compound 232, compound 233, compound 234, compound 235, compound 236, compound 237, compound 238, compound 239, compound 240, compound 241. Preferably, the compound is selected from compound 198, compound 199, compound 206, compound 207, compound 208, compound 236, compound 237, compound 239, compound 240, compound 241; or

[0599] 3) Compound 242, Compound 243, Compound 244, Compound 245, Compound 246. Preferably, the compound is selected from Compound 242, Compound 243, Compound 244, and Compound 245.

[0600] Embodiment 20: A pharmaceutical composition comprising the compound described in any one of Embodiments 1 to 19 above, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound) or prodrug thereof, and optionally a pharmaceutically acceptable excipient.

[0601] Embodiment 21: Use of the compound of any one of Embodiments 1-19, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, or the pharmaceutical composition of Embodiment 20, in the preparation of a medicament for treating and / or preventing a disease or condition associated with the regulation of ubiquitin-specific protease 1 (USP1);

[0602] Preferably, the disease or condition associated with USP1 regulation is a cancer with a defect in the DNA damage repair pathway or a cancer with a defect in homologous recombination;

[0603] Preferably, the disease or condition associated with USP1 regulation is a tumor with a BRCA1 / 2 mutation, a tumor with an ATM mutation, a tumor with an ATR mutation, a tumor resistant to PARP inhibitors, a tumor with a P53 mutation, or a tumor with two or more mutations simultaneously;

[0604] Preferably, the disease or disorder associated with USP1 regulation is cancer comprising cancer cells with elevated levels of RAD18;

[0605] Preferably, the disease or condition associated with USP1 regulation is blood cancer, lymphoma, bone cancer (including osteosarcoma and chondrosarcoma), brain cancer (including glioma, glioblastoma, astrocytoma, medulloblastoma and meningioma), soft tissue cancer (including rhabdomyomas and sarcomas), kidney cancer, bladder cancer, skin cancer (including melanoma), lung cancer (including non-small cell lung cancer), colon cancer, uterine cancer, nervous system cancer, head and neck cancer, pancreatic cancer, cervical cancer, ovarian cancer, peritoneal cancer, endometrial cancer, breast cancer (including triple-negative breast cancer), diabetes.

[0606] Embodiment 22: A pharmaceutical combination comprising: (1) a compound according to any one of Embodiments 1 to 19, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, or the pharmaceutical composition according to Embodiment 20, (2) other anti-tumor drugs;

[0607] Preferably, the other anti-tumor drug is a DNA damaging agent, such as actinomycin, anfloxacin, anthracycline antibiotics, bleomycin, carbosulfan, camptothecin, carboplatin, chloramphenicol, cisplatin, cyclophosphamide, cytotoxin, daunorubicin, doxorubicin, epirubicin, hexamethylmelamine oxaliplatin, ifosfamide, melphalan, pholuramide, mitomycin, mitoxantrone, nitrosoureas, prikamycin, procarbazine, paclitaxel, docetaxel, teniposide, triethylenethiophosphoramide and etoposide; or the DNA damaging agent is a biotherapeutic agent, such as rinterferon-A2A, RNTERFERON-OI2B, RINTERLEUKIN-2, RG-CSF, RGM-CSF and erythropoietin; or

[0608] Preferably, the other anti-tumor drug is a reversible DNA binding agent, such as tobetan hydrochloride, irinotecan (CPT11-camptothecin), diatomaceous earth, itanotecan, nalidixic acid, TAS-103, etoposide, acridines (such as ansacrine, aminoacridine), actinomycins (such as actinomycin D), anthracyclines (such as doxorubicin, daunorubicin), diphenylacetylene, XR11576 / MLN576, benzopyridindole, mitoxantrone, AQ4, etoposide, teniposide, epipodophyllotoxin and double intercalating agents such as treocitin A and echinomycin; or

[0609] Preferably, the other anti-tumor drug is a DNA alkylating agent, such as sulfur mustard, nitrogen mustard (such as methylchloroethylamine), chloramphenicol, melphalan, ethyleneimine (such as triethylenemethylamine, quinolone, diazinon), methyl methanesulfonate, butylsulfonamide, CC-1065, multicarboxylic acid (such as multicarboxylic acid A, multicarboxylic acid SA), metabolically activated alkylating agents such as nitrosoureas (such as carmustine, lomustine, (2-chloroethyl) nitrosourea), triazine anti-tumor drugs such as triazinoimidazole (such as dacarbazine), mitomycin C, lenamycin; or

[0610] Preferably, the other anti-tumor drug is a DNA strand breaking agent, such as doxorubicin and daunorubicin (which are also reversible DNA binding agents), other anthracycline antibiotics, bleomycin, thiazolinone, enediyne anti-tumor antibiotics, such as neocarbazine, espamycin, calicheamicin, dynemycin A, hydracic acid, C-1027, N1999A2, espamycin, zenastatin; or

[0611] Preferably, the other anti-tumor drug is a DNA replication disruptor, such as 5-fluorodeoxyuridine (floxuridine); or

[0612] Preferably, the other anti-tumor drug is an antibody, such as a monoclonal antibody, preferably, the monoclonal antibody includes trastuzumab (e.g., anti-ErbB2 / HER2 for breast cancer), cetuximab (e.g., anti-ErbBL / EGFR for colorectal cancer) and bevacizumab (e.g., anti-VEGF for colorectal cancer, breast cancer and lung cancer), a multi-target inhibitor, such as a solution that inhibits the TK activity of VEGFR, PDGFR and FGFR; or

[0613] Preferably, the other anti-tumor drug is a proteasome inhibitor, such as bortezomib.

[0614] Embodiment 23. Use of the drug combination of embodiment 22 in the preparation of a medicament for treating a tumor or cancer, preferably, the tumor and cancer are selected from: adrenocortical carcinoma, AIDS-related lymphoma, AIDS-related malignant tumors, anal cancer, cerebellar astrocytoma, extrahepatic bile duct carcinoma, bladder cancer, osteosarcoma / malignant fibrous histiocytoma, brain stem glioma, ependymoma, visual pathway and hypothalamic glioma, breast cancer, bronchial adenoma / carcinoid, carcinoid tumor, gastrointestinal carcinoid tumor, adrenocortical carcinoma, pancreatic islet cell carcinoma, primary central nervous system lymphoma, cerebellar astrocytoma, cervical cancer, chronic lymphocytic leukemia, chronic myeloid leukemia, clear cell sarcoma of the tendon sheath, colon cancer, colorectal cancer, cutaneous T-cell lymphoma, endometrial cancer, epididymal tumor, esophageal cancer, Ewing's sarcoma / tumor family, extracranial germ cell tumors, extragerm cell tumors, extrahepatic bile duct cancer, eye cancer (including intraocular melanoma and retinoblastoma), gallbladder cancer, gastrointestinal carcinoid tumors, ovarian germ cell tumors, gestational trophoblastic tumors, hairy cell leukemia, head and neck cancer, Hodgkin's disease, hypopharyngeal cancer, hypothalamic and visual pathway gliomas, Kaposi's glioma Sarcoma, laryngeal cancer, acute lymphoblastic leukemia, acute myeloid leukemia, liver cancer, non-small cell lung cancer, small cell lung cancer, non-Hodgkin's lymphoma, Waldenstrom's macroglobulinemia, malignant thymoma, medulloblastoma, Merkel cell carcinoma, metastatic primary squamous cell carcinoma, multiple endocrine neoplasia syndrome, multiple myeloma / plasmacytoma, fungal disease, myelodysplastic syndrome, chronic myeloid leukemia, myeloid leukemia, multiple myeloma, myeloproliferative disorders, nasal cavity and paranasal sinus cancer, nasopharyngeal cancer, neuroblastoma, oral cancer, oral cavity and lip cancer, oropharyngeal cancer, osteosarcoma / malignant fibrous histiocytoma of bone, ovarian cancer, ovarian low malignant potential tumor, pancreatic cancer, paranasal sinus and nasal cavity cancer, parathyroid cancer, penile cancer, pheochromocytoma, pituitary tumor, thoracic pulmonary blastoma, prostate cancer, rectal cancer, renal cell (kidney) cancer, transitional cell cancer (such as renal pelvis and ureter), rhabdomyosarcoma, salivary gland cancer, malignant fibrous histiocytoma, including bone and soft tissue sarcomas, Sezary syndrome, skin cancer, small intestine cancer, gastric cancer, supradental primitive neuroectodermal and pineal gland tumors, cutaneous T-cell lymphoma, testicular cancer, malignant thymoma, thyroid cancer, urethral cancer, uterine sarcoma, vaginal cancer, vulvar cancer and Wilms' tumor, anaplastic large cell lymphoma, central nervous system cancer, mesothelioma and melanoma, and combinations thereof.

[0615] Embodiment 24: A drug combination comprising: (1) a compound according to any one of Embodiments 1 to 19, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, or the pharmaceutical composition according to Embodiment 20; (2) one or more selected from the group consisting of a PARP inhibitor, an ATM mutation inhibitor, an ATR mutation inhibitor, a P53 mutation modulator, and a wee1 inhibitor;

[0616] Preferably, the PARP inhibitor is selected from: olaparib, niraparib, talazoparib, rucaparib, fuzuloparib, senaparib, veliparib, BGP-15; the ATM inhibitor is selected from: AZD-1390, M-4076, XRD-0394; the ATR inhibitor is selected from: M1774; the P53 agent is selected from: PC14586; the Wee1 inhibitor is selected from: ZN-C3, AZD1775, IMP-7068, SY-4835, MK-1775.

[0617] Embodiment 25: Use of the pharmaceutical combination of Embodiment 24 in the preparation of a medicament for treating tumors or cancers,

[0618] Preferably, the tumor or cancer is a DNA damage repair pathway defective cancer or a homologous recombination defective cancer;

[0619] Preferably, the tumor or cancer is a BRCA1 / 2 mutated tumor, an ATR mutated tumor, an ATM mutated tumor, a P53 mutated tumor, or a tumor with two or more mutations simultaneously;

[0620] Preferably, the tumor or cancer is a PARP inhibitor-resistant or refractory cancer;

[0621] Preferably, the tumor or cancer is a cancer comprising cancer cells with elevated levels of RAD51;

[0622] Preferably, the tumor or cancer is a blood cancer, a lymphoma, a bone cancer (including osteosarcoma and chondrosarcoma), a brain cancer (including glioma, glioblastoma, astrocytoma, medulloblastoma and meningioma), a soft tissue cancer (including rhabdomyomas and sarcomas), a kidney cancer, a bladder cancer, a skin cancer (including melanoma), a lung cancer (including non-small cell lung cancer), a colon cancer, a uterine cancer, a nervous system cancer, a head and neck cancer, a pancreatic cancer, a cervical cancer, an ovarian cancer, a peritoneal cancer, an endometrial cancer, a breast cancer (including triple-negative breast cancer).

[0623] Embodiment 26: A method for preparing the compound according to any one of the above embodiments 1 to 19:

[0624] Formula I-1-1 is subjected to a cyclization reaction to obtain formula I-1-2, formula I-1-2 is subjected to a substitution reaction to obtain formula I-1-3, formula I-1-3 is converted into formula I-1-4, formula I-1-4 and formula I-1-5 are coupled to obtain formula I-1-6, formula I-1-6 and formula I-1-7 are coupled to obtain formula I-1,

[0625] where R p H or R q , P1 is a C1-C6 alkyl group,

[0626] X1 is halogen (preferably Cl or Br) and X2 is -NH-R p , or X2 is halogen (preferably Cl or Br) and X1 is -NH-R p ,

[0627] L is halogen (preferably Cl or Br)

[0628] Ring A, Ring B, R 41 、R 42 、R a 、R b 、R 62 、R 72 , R2, R3, R8, R9, R1, R q is as defined in any one of Embodiments 1 to 19 of the present invention above.

[0629] In some embodiments, Ring B is a 6-membered aromatic ring or a 6-membered heteroaromatic ring.

[0630] In some embodiments, Ring A is a pyrimidine ring.

[0631] In some embodiments R1 is a pyrimidine ring.

[0632] In some embodiments, Ring B is a 6-membered aromatic ring or a 6-membered heteroaromatic ring, and Ring A is a pyrimidine ring.

[0633] In some embodiments, Ring B is a 6-membered aromatic ring or a 6-membered heteroaromatic ring, Ring A is a pyrimidine ring, and R1 is a pyrimidine ring.

[0634] Embodiment 27: A method for preparing the compound according to any one of the above embodiments 1 to 19:

[0635] Formula I-2-1 is subjected to a cyclization reaction to obtain formula I-2-2, formula I-2-2 is subjected to a reaction to obtain formula I-2-3, formula I-2-3 is converted into formula I-2-4, formula I-2-4 and formula I-2-5 are coupled to obtain formula I-2-6, formula I-2-6 and formula I-2-7 are coupled to obtain formula I-2,

[0636] where R p H or R q , P1 is C1-C6 alkyl, X3 is halogen (preferably Cl or Br)

[0637] X1 is halogen (preferably Cl or Br) and X2 is -NH-R p , or X2 is halogen (preferably Cl or Br) and X1 is -NH-R p ,

[0638] L is halogen (preferably Cl or Br)

[0639] Ring A, Ring B, R 41 、R 42 、R a 、R b 、R 62 、R 72 , R2, R3, R8, R9, R1, R q is as defined in any one of Embodiments 1 to 19 of the present invention above.

[0640] In some embodiments, Ring B is a 6-membered aromatic ring or a 6-membered heteroaromatic ring.

[0641] In some embodiments, Ring A is a pyrimidine ring.

[0642] In some embodiments R1 is a pyrimidine ring.

[0643] In some embodiments, Ring B is a 6-membered aromatic ring or a 6-membered heteroaromatic ring, and Ring A is a pyrimidine ring.

[0644] In some embodiments, Ring B is a 6-membered aromatic ring or a 6-membered heteroaromatic ring, Ring A is a pyrimidine ring, and R1 is a pyrimidine ring.

[0645] In addition, this application provides the following embodiments:

[0646] Embodiment 1A: A compound of Formula I, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof.

[0647] in:

[0648] Ring A is selected from C6-C10 aryl, 5-10 membered heteroaromatic ring group (preferably 5-7 membered heteroaromatic ring group), 4-10 membered heterocyclyl group (preferably 4-7 membered heterocyclyl group) and cyclopentadienyl ring group, and the C6-C10 aryl, 5-10 membered heteroaromatic ring group, 4-10 membered heterocyclyl group and cyclopentadienyl ring are optionally substituted by substituents R1, R2, R3, R8, R9;

[0649] Preferably, ring A is selected from a C6-C10 aryl group, a 5-6 membered heteroaromatic ring group, a 5-6 membered heterocyclic group, and a cyclopentadienyl ring group, and the C6-C10 aryl group, the 5-6 membered heteroaromatic ring group, the 5-6 membered heterocyclic group, and the cyclopentadienyl ring group are optionally substituted by substituents R1, R2, R3, R8, and R9;

[0650] More preferably, ring A is selected from a C6-C10 aryl group, a 5-membered heteroaromatic ring group, a 6-membered heteroaromatic ring group, a 5-membered heterocyclic group, a 6-membered heterocyclic group, and a cyclopentadienyl ring group, wherein the 5-membered heteroaromatic ring group and the 5-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; the 6-membered heteroaromatic ring group and the 6-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; and these ring groups are optionally substituted with substituents R1, R2, R3, R8, and R9;

[0651] Further preferably, ring A is selected from pyrimidine ring group, pyridine ring group, triazinyl group (e.g., 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl), pyranyl, thiopyranyl, phenyl, naphthyl, cyclopentadienyl ring group, pyrrole ring group, pyrazol ring group, imidazole ring group, furanyl, thienyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, dihydropyrazole ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane, and these ring groups are optionally substituted with substituents R1, R2, R3, R8, and R9;

[0652] Further more preferably, ring A is selected from a benzene ring, a pyrimidine ring, a pyridine ring, a pyrrole ring, a pyrazole ring, an imidazole ring, and a triazole ring, and the benzene ring, pyrimidine ring, pyridine ring, pyrrole ring, pyrazole ring, imidazole ring, and triazole ring are optionally substituted with substituents R1, R2, R3, R8, and R9;

[0653] Further more preferably, ring A is selected from a pyrimidine ring, a pyridine ring, and a pyrazole ring, and the pyrimidine ring, the pyridine ring, and the pyrazole ring are optionally substituted by substituents R1, R2, R3, R8, and R9;

[0654] Even more preferably, Ring A is selected from

[0655] Still further preferably, Ring A is selected from:

[0656] Even more preferably, Ring A is selected from

[0657] Even more preferably, Ring A is selected from

[0658] Even more preferably, Ring A is selected from

[0659] R1 is selected from 5-7 membered heteroaromatic ring group, saturated or partially unsaturated 4-7 membered heterocyclic group, 6-10 membered aryl group, C3-C8 cycloalkyl group, and the 5-7 membered heteroaromatic ring group, saturated or partially unsaturated 4-7 membered heterocyclic group, 6-10 membered aryl group, C3-C8 cycloalkyl group is optionally substituted by R a 、R b 、R c replaced by;

[0660] Preferably, R1 is selected from 5-6 membered heteroaromatic ring group, 5-6 membered heterocyclic group, 6-10 membered aryl group, and the 5-6 membered heteroaromatic ring group, 5-6 membered heterocyclic group, 6-10 membered aryl group is optionally substituted by R a 、R b 、R c replaced by;

[0661] More preferably, R1 is selected from a 5-membered heteroaromatic ring group, a 6-membered heteroaromatic ring group, and a 6-membered aryl group, wherein the 5-membered heteroaromatic ring group contains 1-2 heteroatoms selected from N atoms, O atoms, and S atoms (preferably N atoms); the 6-membered heteroaromatic ring group contains 1-2 heteroatoms selected from N atoms, O atoms, and S atoms (preferably N atoms); these ring groups are optionally substituted with R a 、R b 、R c replaced by;

[0662] Further preferably, R1 is selected from: pyrimidine ring group, pyridine ring group, triazine group (such as 1,2,3-triazine group, 1,2,4-triazine group, 1,3,5-triazine group), pyranyl, thiopyranyl, phenyl, naphthyl, cyclopentadienyl ring group, pyrrole ring group, pyrazole ring group, imidazole ring group, furanyl, thienyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, dihydropyrazole ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane; these ring groups are optionally substituted by R a 、R b 、R c replaced by;

[0663] Still further preferably, R1 is selected from pyrimidine ring group, pyridine ring group, pyrazole ring group, pyrrole ring group, phenyl group, and these ring groups are optionally substituted by R a 、R b 、R c replaced by;

[0664] Still further preferably, R1 is selected from pyrimidine ring group, pyridine ring group, pyrazole ring group, phenyl group, and these ring groups are optionally substituted by R a 、R b 、R c replaced by;

[0665] Even more preferably, R1 is selected from:

[0666] Still more preferably, R1 is selected from:

[0667] More preferably, R1 is selected from:

[0668] Even more preferably, R1 is selected from: Among them, R a 、R b 、R c Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1, where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a 、R b 、R cR is independently selected from the group consisting of hydrogen, halogen, cyano, C1-C6 alkyl, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, C1-C6 alkoxy (optionally deuterated) which is unsubstituted or optionally substituted by C1-C6 alkoxy, C1-C6 alkylthio, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by C1-C6 alkoxy, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by hydroxy, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, amino which is optionally substituted by 1-2 C1-C6 alkyl groups, 4-7 membered heterocyclic group containing 1 heteroatom selected from N atom, O atom and S atom as a ring atom, and amino C1-C6 acyl which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl groups; more preferably, R a 、R b 、R c Each is independently selected from the group consisting of hydrogen, chlorine, cyano, isopropyl, methyl, tert-butyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuterated methoxy, cyclopropyl, difluorocyclopropyl, methoxymethyl-substituted cyclopropyl, hydroxy-substituted cyclopropyl, methylthio, dimethylamino, isopropylamino, oxetanyl, and N-methylcarbamoyl;

[0669] Even more preferably, R1 is selected from: Among them, R a 、R b 、R c Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), wherein the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted by one or more halogen or deuterium; more preferably, R a 、R b 、R c are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a 、R b 、R cEach is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuterated methoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a 、R b 、R c Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy;

[0670] More preferably, R1 is selected from any one of the groups 1) to 5):

[0671] 1) R a1 、R b1 、R c1 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3, where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl; preferably, R a1 、R b1 、R c1 are each independently selected from the group consisting of: hydrogen, C1-C6 alkyl, C1-C6 alkoxy (optionally deuterated) which is unsubstituted or optionally substituted by C1-C6 alkoxy, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, halogen, C1-C6 alkylthio, cyano, amino which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl grou...

Claims

1. A compound of Formula I, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, in: Ring A is selected from C6-C10 aryl, 5-10 membered heteroaromatic ring group (preferably 5-7 membered heteroaromatic ring group), 4-10 membered heterocyclyl group (preferably 4-7 membered heterocyclyl group) and cyclopentadienyl ring group, and the C6-C10 aryl, 5-10 membered heteroaromatic ring group, 4-10 membered heterocyclyl group and cyclopentadienyl ring are optionally substituted by substituents R1, R2, R3, R8, R9; Preferably, ring A is selected from a C6-C10 aryl group, a 5-6 membered heteroaromatic ring group, a 5-6 membered heterocyclic group, and a cyclopentadienyl ring group, and the C6-C10 aryl group, the 5-6 membered heteroaromatic ring group, the 5-6 membered heterocyclic group, and the cyclopentadienyl ring group are optionally substituted by substituents R1, R2, R3, R8, and R9; More preferably, ring A is selected from a C6-C10 aryl group, a 5-membered heteroaromatic ring group, a 6-membered heteroaromatic ring group, a 5-membered heterocyclic group, a 6-membered heterocyclic group, and a cyclopentadienyl ring group, wherein the 5-membered heteroaromatic ring group and the 5-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; the 6-membered heteroaromatic ring group and the 6-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; and these ring groups are optionally substituted with substituents R1, R2, R3, R8, and R9; Further preferably, ring A is selected from pyrimidine ring group, pyridine ring group, triazinyl group (e.g., 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl), pyranyl, thiopyranyl, phenyl, naphthyl, cyclopentadienyl ring group, pyrrole ring group, pyrazol ring group, imidazole ring group, furanyl, thienyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, dihydropyrazole ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane, and these ring groups are optionally substituted with substituents R1, R2, R3, R8, and R9; Further more preferably, ring A is selected from a benzene ring, a pyrimidine ring, a pyridine ring, a pyrrole ring, a pyrazole ring, an imidazole ring, and a triazole ring, and the benzene ring, pyrimidine ring, pyridine ring, pyrrole ring, pyrazole ring, imidazole ring, and triazole ring are optionally substituted with substituents R1, R2, R3, R8, and R9; Further more preferably, ring A is selected from a pyrimidine ring, a pyridine ring, and a pyrazole ring, and the pyrimidine ring, the pyridine ring, and the pyrazole ring are optionally substituted by substituents R1, R2, R3, R8, and R9; Even more preferably, Ring A is selected from Still further preferably, Ring A is selected from: Even more preferably, Ring A is selected from Even more preferably, Ring A is selected from Even more preferably, Ring A is selected from R1 is selected from 5-7 membered heteroaromatic ring group, saturated or partially unsaturated 4-7 membered heterocyclic group, 6-10 membered aryl group, C3-C8 cycloalkyl group, and the 5-7 membered heteroaromatic ring group, saturated or partially unsaturated 4-7 membered heterocyclic group, 6-10 membered aryl group, C3-C8 cycloalkyl group is optionally substituted by R a 、R b 、R c replaced by; Preferably, R1 is selected from 5-6 membered heteroaromatic ring group, 5-6 membered heterocyclic group, 6-10 membered aryl group, and the 5-6 membered heteroaromatic ring group, 5-6 membered heterocyclic group, 6-10 membered aryl group is optionally substituted by R a 、R b 、R c replaced by; More preferably, R1 is selected from a 5-membered heteroaromatic ring group, a 6-membered heteroaromatic ring group, and a 6-membered aryl group, wherein the 5-membered heteroaromatic ring group contains 1-2 heteroatoms selected from N atoms, O atoms, and S atoms (preferably N atoms); the 6-membered heteroaromatic ring group contains 1-2 heteroatoms selected from N atoms, O atoms, and S atoms (preferably N atoms); these ring groups are optionally substituted with R a 、R b 、R c replaced by; Further preferably, R1 is selected from: pyrimidine ring group, pyridine ring group, triazine group (such as 1,2,3-triazine group, 1,2,4-triazine group, 1,3,5-triazine group), pyranyl, thiopyranyl, phenyl, naphthyl, cyclopentadienyl ring group, pyrrole ring group, pyrazole ring group, imidazole ring group, furanyl, thienyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, dihydropyrazole ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane; these ring groups are optionally substituted by R a 、R b 、R c replaced by; Still further preferably, R1 is selected from pyrimidine ring group, pyridine ring group, pyrazole ring group, pyrrole ring group, phenyl group, and these ring groups are optionally substituted by R a 、R b 、R c replaced by; Still further preferably, R1 is selected from pyrimidine ring group, pyridine ring group, pyrazole ring group, phenyl group, and these ring groups are optionally substituted by R a 、R b 、R c replaced by; Even more preferably, R1 is selected from: Still more preferably, R1 is selected from: More preferably, R1 is selected from: Even more preferably, R1 is selected from: in, R a 、R b 、R c Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkyne alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, C1-C6 alkyloxy-C1-C6 alkyl, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a 、R b 、R c and each is independently selected from the group consisting of hydrogen, halogen, cyano, C1-C6 alkyl, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by C1-C6 alkoxy (optionally deuterated), C1-C6 alkoxy which is unsubstituted or optionally substituted by 1-9 halogen atoms (optionally deuterated), C1-C6 alkylthio, C1-C6 alkoxy which is unsubstituted or optionally substituted by C1-C6 alkoxy More preferably, R a 、R b 、R c Each is independently selected from the group consisting of hydrogen, chlorine, cyano, isopropyl, methyl, tert-butyl, trifluoromethyl, methoxy, ethoxy, methoxymethoxy, methoxyethoxy, trideuteromethoxy, difluoromethoxy, fluoromethoxy, cyclopropyl, difluorocyclopropyl, methoxymethyl-substituted cyclopropyl, hydroxy-substituted cyclopropyl, methylthio, dimethylamino, isopropylamino, oxetanyl, and N-methylcarbamoyl; Even more preferably, R1 is selected from: in, R a 、R b 、R c Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), wherein the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted by one or more halogen or deuterium; more preferably, R a 、R b 、R c are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a 、R b 、R c Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuterated methoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a 、R b 、R c Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy; More preferably, R1 is selected from any one of the groups 1) to 5): 1) R a1 、R b1 、R c1 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl; preferably, R a1 、R b1 、R c1 are each independently selected from the group consisting of: hydrogen, C1-C6 alkyl, C1-C6 alkoxy (optionally deuterated) which is unsubstituted or optionally substituted by C1-C6 alkoxy, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, halogen, C1-C6 alkylthio, cyano, amino which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl groups; more preferably, R a1 、R b1 、R c1 Each is independently selected from the group consisting of hydrogen, isopropyl, methoxy, cyclopropyl, methoxyethoxy, methyl, chloro, tert-butyl, ethoxy, trideuteromethoxy, difluorocyclopropyl, methylthio, cyano, and dimethylamino; 2) R a2 、R b2 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a2 、R b2 Each is independently selected from: hydrogen, C1-C6 alkyl, amino which is unsubstituted or optionally substituted with 1-2 C1-C6 alkyl groups, C1-C6 alkoxy, cyano, C3-C8 cycloalkyl, C1-C6 alkylthio; more preferably, R a2 、R b2 Each is independently selected from the group consisting of: hydrogen, isopropyl, methyl, dimethylamino, methoxy, cyano, cyclopropyl, methylthio, isopropylamino; 3) R a3 、R b3 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a3 、R b3 Each is independently selected from: hydrogen, halogen, a 4-7 membered heterocyclic group containing one heteroatom selected from a N atom, an O atom, or a S atom as a ring atom, a cyano group, a C1-C6 alkyl group, a C3-C8 cycloalkyl group which is unsubstituted or optionally substituted by a C1-C6 alkyl group which is substituted by a C1-C6 alkoxy group, or a C1-C6 alkyl group which is unsubstituted or optionally substituted by 1-9 halogen atoms; more preferably, R a3 、R b3 Each is independently selected from the group consisting of: hydrogen, chlorine, oxetanyl, cyano, isopropyl, methoxymethyl-substituted cyclopropyl, trifluoromethyl, methyl; 4) R a4 、R b4 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a4 、R b4 Each independently selected from: hydrogen, cyano, C1-C6 alkyl, halogen; More preferably, R a4 、R b4 Each independently selected from: hydrogen, cyano, isopropyl, chloro; 5) R a5 、R b5 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 are each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl or deuterium; preferably, R a5 、R b5 Each is independently selected from: hydrogen, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by hydroxy, C1-C6 alkyl, amino C1-C6 acyl which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl, C1-C6 alkylthio; more preferably, R a5 、R b5 Each is independently selected from: hydrogen, hydroxy-substituted cyclopropyl, isopropyl, N-methylcarbamoyl, methylthio; Still more preferably, R1 is selected from any one of the groups 1) to 13): 1) R a11 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a11 is selected from: hydrogen, C1-C6 alkyl; more preferably, R a11 Selected from: hydrogen, isopropyl; 2) R a12 、R b12 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1- C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a12 、R b12 are each independently selected from the group consisting of: hydrogen, C1-C6 alkyl, C1-C6 alkoxy (optionally deuterated) which is unsubstituted or optionally substituted by C1-C6 alkoxy, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, halogen, C1-C6 alkylthio, cyano, amino which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl groups; more preferably, R a12 、R b12 Each is independently selected from the group consisting of hydrogen, methoxy, difluoromethoxy, ethyl, cyclopropyl, isopropyl, methoxyethoxy, methyl, chloro, tert-butyl, ethoxy, trideuteromethoxy, difluorocyclopropyl, methylthio, cyano, and dimethylamino; 3) R a13 、R b13 、R c13 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a13 、R b13 、R c13 Each is independently selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, C3-C8 cycloalkyl; more preferably, R a13 、 R b13 、R c13 Independently selected from: hydrogen, methoxy, methyl, cyclopropyl; 4) R a21 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a21 is selected from: hydrogen, C1-C6 alkyl, amino which is unsubstituted or optionally substituted with 1-2 C1-C6 alkyl groups; more preferably R a21 Selected from: hydrogen, isopropyl, isopropylamino; 5) R a22 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 are each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, any R is an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 alkyloxy, an optionally substituted hydroxyl C1-C6 alkyl, an optionally substituted C1-C6 alkylthio), a cyano group, a carboxyl group, an optionally substituted 4-7 membered heterocyclyl group containing 1-2 members selected from N, O or S as ring atoms, and an optionally substituted C1-C6 alkylcarbonyl group, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano group, carboxyl group, or deuterium; preferably, R a22 Selected from: hydrogen, C1-C6 alkoxy; More preferably, R a22 Selected from: hydrogen, methoxy; 6) R a23 、R b23 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a23 、R b23 Each is independently selected from: hydrogen, C1-C6 alkoxy, cyano, C3-C8 cycloalkyl, C1-C6 alkylthio, C1-C6 alkyl; More preferably, R a23 、R b23 Each is independently selected from: hydrogen, methoxy, cyano, cyclopropyl, methylthio, methyl; 7) R a24 、R b24 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl), optionally Substituted amino C1-C6 acyl (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a24 、R b24 Each is independently selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl; more preferably, R a24 、R b24 Each independently selected from: hydrogen, methoxy, methyl; 8) R a31 、R b31 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a31 、R b31 Each is independently selected from: hydrogen, halogen, a 4-7 membered heterocyclic group containing one heteroatom selected from a N atom, an O atom, or a S atom as a ring atom, a cyano group, a C1-C6 alkyl group, a C3-C8 cycloalkyl group which is unsubstituted or optionally substituted by a C1-C6 alkyl group which is substituted by a C1-C6 alkoxy group, or a C1-C6 alkyl group which is unsubstituted or optionally substituted by 1-9 halogen atoms; more preferably, R a31 、R b31 Each is independently selected from the group consisting of: hydrogen, chlorine, oxetanyl, cyano, isopropyl, methoxymethyl-substituted cyclopropyl, trifluoromethyl, methyl; 9) R a41 、R b41 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a41 、R b41 Each is independently selected from: hydrogen, cyano, C1-C6 alkyl; more preferably, R a41 、R b41 Each independently selected from: hydrogen, cyano, isopropyl; 10) R a42 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 are each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 ring atoms selected from N, O or S, and optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a42 is selected from: hydrogen, C1-C6 alkyl; more preferably, R a42 Selected from: hydrogen, isopropyl; 11) R a43 、R b43 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a43 、R b43 Each independently selected from: hydrogen, C1-C6 alkyl, halogen; More preferably, R a43 、R b43 Each independently selected from: hydrogen, isopropyl, chloro; 12) R a51 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a51 is selected from: hydrogen, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by hydroxy, C1-C6 alkyl, amino C1-C6 acyl which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl groups; more preferably, R a51 Selected from: hydrogen, hydroxy substituted cyclopropyl, isopropyl, N-methylcarbamoyl; 13) R a52 、R b52 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R a52 、R b52 Each is independently selected from: hydrogen, C3-C8 cycloalkyl, C1-C6 alkylthio; more preferably, R a52 、R b52 Each independently selected from: hydrogen, cyclopropyl, methylthio; Still more preferably, R1 is selected from any one of the groups 1) to 5): 1) R a12 、R b12 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkoxy Thio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogen or deuterium; preferably, R a12 、R b12 are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a12 、R b12 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, difluoromethoxy, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a12 、R b12 Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy; 2) R a23 、R b23 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogen or deuterium; preferably, R a23 、R b23 are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a23 、R b23 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, and difluorocyclopropyl; R a23 、R b23 More preferably, it is selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuterated methoxy; 3) R a24 、R b24 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogen or deuterium; preferably, R a24 、R b24 are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a24 、R b24 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a24 、R b24 Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy; 4) R a31 、R b31 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NRd1Re1 (wherein R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogens; preferably, R a31 、R b31 Each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 halogen More preferably, R a31 、R b31 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a31 、R b31 Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy; 5) R a52 、R b52 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted by one or more halogen or deuterium; preferably, R a52 、R b52 are each independently selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, deuterated C1-C6 alkoxy; more preferably, R a52 、R b52 Each is independently selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl; more preferably, R a52 、R b52 Each is independently selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuteromethoxy; R3 is selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted with 1 or multiple halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium substitution; preferably, R3 is selected from: hydrogen, C1-C6 alkyl, halogen, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C1-C6 haloalkoxy, more preferably, R3 is selected from: hydrogen, C1-C6 alkyl; more preferably, R3 is selected from: hydrogen, methyl; R2 is selected from the group consisting of hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkane alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium substitution; preferably, R2 is selected from: hydrogen, C1-C6 alkyl, halogen, C1-C6 alkoxy, C3-C6 cycloalkyl, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C1-C6 haloalkoxy, C1-C6 acyl; more preferably, R2 is selected from: hydrogen, C1-C6 alkyl, C1-C6 acyl, C3-C8 cycloalkyl, halogen; more preferably, R2 is selected from: H, halogen, C1-C3 alkyl, C1-C3 acyl, C3-C4 cycloalkyl; more preferably, R2 is selected from: hydrogen, methyl, ethyl, cyclopropyl, chlorine, fluorine, acetyl; R8 and R9 are each independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), (where X6 is O, S or NR x Where N is the attachment site, R z is an optionally substituted C1-C6 alkyl group, R x is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is an optionally substituted C1-C6 alkyl, an optionally substituted C2-C8 alkenyl, an optionally substituted C2-C8 alkynyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 alkyloxy, an optionally substituted hydroxyC1-C6 alkyl, or an optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, optionally substituted C1-C6 alkylsulfinyl (-S(O)R f ,in R f is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkylsulfonyl (-S(O)2R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted di(C1-C6 alkyl)phosphinyl ( where R g 、R h (C1-C6 alkyl group is optionally substituted), wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from optionally substituted H, optionally substituted C1-C6 alkyl or optionally substituted C3-C8 cycloalkyl), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl group or an optionally substituted C3-C6 cycloalkyl group), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C3-C6 cycloalkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group), -S(O)R f (where R f is an optionally substituted C1-C6 alkyl), -S(O)2R f (where R f is an optionally substituted C1-C6 alkyl), (where R g 、R h (optionally substituted C1-C6 alkyl), wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, amino, or deuterium; Preferably, R8 and R9 are each independently selected from the group consisting of hydrogen, C1-C6 acyl which is unsubstituted or optionally substituted by 1-9 halogen atoms or by C3-C8 cycloalkyl or by C3-C8 cycloalkyloxy, aminoC1-C3 acyl which is unsubstituted or optionally substituted by C3-C8 cycloalkyl or by 1-2 C1-C6 alkyl (optionally deuterated), oxyC1-C3 acyl which is unsubstituted or optionally substituted by C3-C8 cycloalkyl, amino which is unsubstituted or optionally substituted by 1-2 C1-C6 alkyl or C3-C8 cycloalkyl, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, C3-C8 cycloalkyl which is unsubstituted or optionally substituted by C1-C6 alkyl, C1-C6 alkylsulfonyl, and di(C1-C6 alkyl)phosphinyl. More preferably, R8 and R9 are each independently selected from: H, C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl or C3-C6 cycloalkyloxy), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group), -NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl or C3-C6 cycloalkyl), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl), C1-C6 alkyl-substituted C3-C6 cycloalkyl; more preferably selected from: hydrogen, methyl, acetyl, trifluoropropionyl, propionyl, cyclopropylcarbamoyl, trifluoroacetyl, N-cyclopropylcarbamoyl, N-isopropylcarbamoyl, N-trideuterated methylcarbamoyl, azetidinylcarbamoyl, N,N-dimethylcarbamoyl, N-methyl-N-cyclopropylcarbamoyl, carbamoyl, N-methylcarbamoyl, cyclopropyloxycarbamoyl, methylamino, methylcyclopropylamino, trifluoromethyl, methylcyclopropyl, ethyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl; More preferably, R8 and R9 are each independently selected from: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, or R2, R8 or R2, R9 together with the atoms to which they are attached form Wherein * represents the position of the atom to which R2, R8 or R2, R9 are connected; preferably R2, R8 or R2, R9 together with the atoms to which they are connected form Where * indicates the position of the atom to which R2, R8 or R2, R9 are respectively connected; Ring B is selected from 5-15 membered heteroaromatic ring group, 4-15 membered heterocyclic group, C4-C7 cycloalkyl group, 6-10 membered aryl group and bridged ring C4-C20 hydrocarbon group, and the 5-15 membered heteroaromatic ring group, 4-15 membered heterocyclic group, C4-C7 cycloalkyl group, 6-10 membered aryl group and bridged ring C4-C20 hydrocarbon group are optionally substituted by R 41 、R 42 , replaced by R5; Preferably, the B ring is selected from a 5-14 membered heteroaromatic ring group, a 4-14 membered heterocyclic group, a C5-C6 cycloalkyl group, a 6 membered aryl group and a bicyclic bridged C4-C10 hydrocarbon group, and the 5-14 membered heteroaromatic ring group, the 4-14 membered heterocyclic group, the C5-C6 cycloalkyl group, the 6 membered aryl group and the bicyclic bridged C4-C10 hydrocarbon group are optionally substituted by R 41 、R 42 , replaced by R5; More preferably, the B ring is selected from a 5-membered heteroaromatic ring group, a 6-membered heteroaromatic ring group, a 4-membered heterocyclic group, a 5-membered heterocyclic group, a 6-membered heterocyclic group, a 7-14-membered bicyclic or tricyclic condensed heteroaromatic ring group, a 7-14-membered bicyclic or tricyclic condensed heterocyclic group, a C5-C6 cycloalkyl group, a 6-membered aryl group, and a bicyclic bridged C4-C10 hydrocarbon group, wherein the 5-membered heteroaromatic ring group and the 5-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; the 6-membered heteroaromatic ring group and the 6-membered heterocyclic group contain 1-2 heteroatoms selected from N atoms, O atoms, and S atoms (preferably N atoms); the 4-membered heterocyclic group contains 1-2 heteroatoms selected from N atoms; and these ring groups are optionally substituted with R 41 、R 42 , replaced by R5; Further preferably, the B ring is selected from pyrrole ring group, pyrazol ring group, imidazole ring group, furan ring group, thienyl ring group, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, dihydropyrazol ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, tetrahydropyrrole ring group, pyridine ring group, pyrimidine ring group, triazinyl (e.g., 1,2,3-triazinyl, 1,2,4-triazinyl, 1,3,5-triazinyl), pyranyl, thiopyranyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane, hexahydropyrazinyl, azetidinyl, indolyl, 5-azaindole Indole, pyrrolo[2,3-d]pyrimidinyl, 5,6-diazaindolyl, 6-azaindolyl, 7-azaindolyl, pyrazolo[3,4-b]pyridinyl, pyrrolo[2,3-c]pyridazinyl, thieno[2,3-d]imidazolyl, thieno[2,3-d]imidazolyl, pyrazolo[3,4-c]pyridinyl, benzothiazolyl, benzimidazolyl, benzoxazolyl, benzothienyl, quinolinyl, isoquinolinyl, benzofuranyl, indolizinyl, quinoxalinyl, indazolyl, pyrrolopyrimidinyl, furopyridinyl, isoindolyl, cyclohexyl, phenyl, bicyclo[1.1.1]pentanyl, bicyclo[1.2.2]heptanyl, bicyclo[2.2.2]octanyl, wherein these ring groups are optionally substituted with R 41 、R 42 , replaced by R5; More preferably, the B ring is selected from a benzene ring, pyridine, pyrimidine, bicyclo[1.2.2]heptyl, bicyclo[2.2.2]octyl, and the benzene ring, pyridine, pyrimidine, bicyclo[1.2.2]heptyl, bicyclo[2.2.2]octyl is optionally substituted with R 41 、R 42 , replaced by R5; Even more preferably, Ring B is selected from Even more preferably, Ring B is selected from More preferably, the B ring is selected from More preferably, the B ring is selected from R 41 、R 42 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R 41 、R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; more preferably, R 41 、R 42 Each is independently selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxyl; more preferably, R 41 、R 42 Each independently selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxyl; R5 is selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted containing 1-2 selected from N, O or S is a 4-15 membered heterocyclyl, an optionally substituted 4-15 membered heteroaryl, an optionally substituted 6-10 membered aryl, or an optionally substituted C1-C6 alkylcarbonyl group, wherein The "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, deuterated C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; the 4-1-2 alkyl radicals containing 1-2 N, O or S as ring atoms are selected from N, O or S. The 5-membered heterocyclic group is preferably selected from the group consisting of: dihydropyrazole ring group, pyrrolidinyl, imidazolinyl, oxazolidinyl, isoxazolinyl, thiazolidinyl, tetrahydrofuranyl, tetrahydropyrrole ring group, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopiperidinyl, 2-oxopyrrolidinyl, 1-pyridonyl, 4-piperidonyl, tetrahydropyranyl, morpholinyl, 1,3-dioxolane, hexahydropyrazinyl, azetidinyl, oxetanyl, thietanyl; The 4-15 membered heteroaryl group is preferably selected from the group consisting of: pyrrole ring group, pyrazole ring group, imidazole ring group, furan ring group, thiophene ring group, oxazolyl group, thiazolyl group, isoxazolyl group, isothiazolyl group, pyridine ring group, pyrimidine ring group, triazine group (e.g., 1,2,3-triazine group, 1,2,4-triazine group, 1,3,5-triazine group), pyranyl group, thiopyranyl group, indolyl group, 5-azaindolyl group, pyrrolo[2,3-d]pyrimidinyl group, 5,6-diazaindolyl group, 6-azaindolyl group indolyl, 7-azaindolyl, pyrazolo[3,4-b]pyridinyl, pyrrolo[2,3-c]pyridazinyl, thieno[2,3-d]imidazolyl, thieno[2,3-d]imidazolyl, pyrazolo[3,4-c]pyridinyl, benzothiazolyl, benzimidazolyl, benzoxazolyl, benzothienyl, quinolyl, isoquinolyl, benzofuranyl, indolizinyl, quinoxalinyl, indazolyl, pyrrolopyrimidinyl, furopyridinyl, isoindolyl; Preferably, R5 is selected from optionally substituted 4-15 membered heteroaryl, optionally substituted 6-10 membered aryl, wherein, The "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), optionally substituted 4-7 membered heterocyclic group containing 1-2 heteroatoms selected from N, O or S; the 4-15 membered heteroaryl group is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, furan ring group, thiophene ring group, oxazolyl group, thiazolyl group, isoxazolyl group, isothiazolyl group, pyridine ring group, pyrimidine ring group, triazinyl group (e.g., 1,2,3-triazinyl group, 1,2,4-triazinyl group, 1,3,5-triazinyl group), pyranyl group, thiopyranyl group; More preferably, R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; More preferably, R5 is selected from any one of the groups (1) to (7): (1) Preferred in, W1, W2 are each independently selected from C or N, R m Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 are each independently selected from optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkane alkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is an optionally substituted C1-C6 alkyl, an optionally substituted C2-C8 alkenyl, an optionally substituted C2-C8 alkynyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 alkyloxy, an optionally substituted hydroxyC1-C6 alkyl, or an optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 ring atoms selected from N, O or S, and optionally Substituted C1-C6 alkylcarbonyl; the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; the "optionally substituted" means preferably substituted by C1-C6 alkyl, the "optionally substituted" means preferably substituted by methyl; Preferably selected from: (2) unsubstituted or optionally substituted by R m 、R n A substituted 5-membered heteroaryl group, wherein the 5-membered heteroaryl ring group contains 1-2 heteroatoms selected from N atoms, O atoms, and S atoms; the 5-membered heteroaryl ring group is more preferably selected from: furan ring group, thiophene ring group, pyrrole ring group; the 5-membered heteroaryl ring group is even more preferably selected from: as well as (Preferred )(in, R m 、R n independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NRa1'Rb1', wherein Ra1', Rb1' are optionally substituted C1-C6 alkyl, optionally substituted amino (-NRa1'Rb1', wherein Ra1', Rb1' are optionally substituted C1-C6 alkyl, optionally substituted amino (-NRa1' d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 1-2 rings selected from N, O or S a 4-7 membered heterocyclic group containing 2-3 halogen atoms and an optionally substituted C1-C6 alkylcarbonyl group, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium, substituted; the "optionally substituted" means preferably substituted by a C1-C6 alkyl group which is unsubstituted or optionally substituted by 1-9 halogen atoms, and the "optionally substituted" means more preferably substituted by a trifluoromethyl group or a methyl group; preferably, for )； (3) (Preferred ),in, R m 、R n Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m and R n Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 are each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m and R n Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; Even more preferably, R5 is selected from in, R m1 、R n1 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl; the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 and R n1 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m1 and R n1 Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3、-CH2F、-CHF2、 Morpholinyl; Alternatively, R5 is selected from in, R m2 、R n2 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m2 、R n2 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m2 、R n2 Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; or, R5 is selected from in, R m3 、R n3 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m3 、R n3 Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; (4) unsubstituted or optionally substituted by R m 、R n substituted 1,2,4-triazole ring group, 1,2,3-triazole ring group, 1,2,4-oxadiazole ring group or isoxazole ring group, R m 、R n Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、 R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m and R n Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m and R n Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; More preferably, R5 is selected from in, R m1 、R n1 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 For optional substituted C1-C6 alkyl), optionally substituted amino C1-C6 acyl (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m1 、R n1 Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; or, R5 is selected from in, R m2 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 - C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m2 is selected from: hydrogen, C1-C6 alkyl; more preferably, R m2 Selected from: hydrogen, methyl; or R5 is selected from in, R m3 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl; the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 is selected from: hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms; more preferably, R m3 Selected from: hydrogen, trifluoromethyl; R5 is selected from in, R m4 、R n4 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl), optionally Substituted amino C1-C6 acyl (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m4 、R n4 Each is independently selected from the group consisting of hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1 to 9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m4 、R n4 Each independently selected from: hydrogen, trifluoromethyl; (5) or a 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, preferably (6) Preferred R m 、R n Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 are each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 R is an optionally substituted C1-C6 alkyl, an optionally substituted C2-C8 alkynyl, an optionally substituted C3-C8 cycloalkyl, an optionally substituted C1-C6 alkyloxy, an optionally substituted hydroxyl C1-C6 alkyl, an optionally substituted C1-C6 alkylthio), a cyano group, a carboxyl group, an optionally substituted 4-7 membered heterocyclyl group containing 1-2 members selected from N, O or S as ring atoms, and an optionally substituted C1-C6 alkylcarbonyl group; the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano group, carboxyl group, deuterium; preferably, R m 、R n is selected from the group consisting of: hydrogen, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms, C1-C6 alkoxy which is unsubstituted or optionally substituted by 1-9 halogen atoms, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, cyano, nitro, halogen, C3-C8 cycloalkyl, an optionally substituted 4-7 membered heterocyclic group containing one heteroatom selected from N atom, O atom, S atom as a ring atom, an optionally substituted amino group (-NR d1 R e1 , where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl which is unsubstituted or substituted by 1-3 halogens or deuterium), C1-C6 amide (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio); more preferably, R m 、R n Selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; Preferably, in, R m1 Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 selected from N, O or S as ring atoms and optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkoxy, C1-C6 alkylthio ... alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium substitution; preferably, R m is selected from: hydrogen, a 4-7 membered heterocyclic group containing 1-2 heteroatoms selected from N atoms, O atoms, and S atoms as ring atoms, a C1-C6 alkoxy group, a C3-C8 cycloalkoxy group, an amino group which is unsubstituted or optionally substituted with 1-2 C1-C6 alkyl groups; more preferably, R m Selected from: hydrogen, morpholinyl, methoxy, cyclopropyloxy, dimethylamino; or in, R m2 、R n2 Each is independently selected from hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 R is each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy, C1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 members selected from N, O or S as ring atoms, and optionally substituted C1-C6 alkylcarbonyl, wherein the “optionally substituted” means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m2、 R n2 Each is independently selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms; more preferably, R m2、 R n2 Each independently selected from: hydrogen, methoxy, trifluoromethyl, methyl; (7) (Preferred ),in, R m Selected from: hydrogen, halogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, nitro, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted Substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), cyano, carboxyl, optionally substituted 4-7 membered heterocyclyl containing 1-2 ring atoms selected from N, O or S, and Optionally substituted C1-C6 alkylcarbonyl, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably selected from: hydrogen, C3-C8 cycloalkoxy, C1-C6 alkyl; more preferably selected from: hydrogen, cyclopropyloxy, methyl; More preferably, R5 is selected from any one of the groups (i) to (iii): (i) (Preferred ),in, R m 、R n Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 R is each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Each is independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Each is independently selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; Even more preferably, R5 is selected from R m1 、R n1 Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, an optionally substituted 4-7 membered heterocyclic group containing 1-2 members selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium substitution; preferably selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; Even more preferably, R5 is selected from in, R m3 、R n3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein "optionally substituted" means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably selected from: hydrogen, trifluoromethyl, methoxy, methyl, -CD3, -OCD3, -NHCD3, cyano, nitro, fluorine, chlorine, ethoxy, isopropyl, cyclopropyl, azetidinyl, oxetanyl, cyclobutyl, acetylamino, ethyl, -CH2CF3, -CH2F, -CHF2, Morpholinyl; (ii) Preferred R m 、R n Each is independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Each is independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Each is independently selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, deuterated methoxy, -NHCD3; (iii) (Preferred ),in, R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, deuterated methoxy, -NHCD3; X5 is selected from the group consisting of: direct bond, -NH-, -O-, -S-, -C(O)-, -S(O)2-, -S(O)-, -N(R q )-、 where R q is selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, optionally substituted C1-C6 acyl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium, preferably, R q is selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably, R q Selected from: methyl, ethyl, n-propyl or isopropyl; Preferably, X5 is selected from: -NH-, -C(O)-, -S(O)2-, -S(O)-, -N(R q )-、 where R q is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl; More preferably, X5 is selected from the group consisting of: direct bond, -NH-, -N(CH3)-, -O-, -S-, -C(O)-, -S(O)2-, -S(O)-, Most preferably, X5 is selected from -NH-, -N(CH3)-, -N(C(O)CH3)-; n1 is selected from 0, 1, 2, 3, 4, preferably 0, 1, and most preferably 0; n2 is selected from 0, 1, 2, 3, 4, preferably 0, 1, 2, and most preferably 1; and when one of them is 0, the other is not 0; when one is not 0, the other is 0; most preferably, n1 is 0 and n2 is 1; R 61 、R 62 、R 71 、R 72 , when present, are each independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; more preferably, R 61 、R 62 、R 71 、R 72 Each independently selected from: hydrogen, methyl, ethyl, or, R 61 With R 71 or R 62 With R 72 Together form a C3-C8 cycloalkylene group or =O, preferably, R 61 With R 71 or R 62 With R 72 Together ＝O； The above-mentioned compound satisfies the following conditions: When R8 is methyl, R1 is not When R8 is -NR d1 R e1 When R1 is not When R8 is -NH2, -COOH, -C(=O)O-C2H5, -CH2-NH2, -CN, When R1 is not and the compound is not:

2. The compound of claim 1, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: When R8, R9 are each independently selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxy C1-C6 alkyl, optionally substituted C1-C6 alkylthio, optionally substituted amino (-NR d1 R e1 , where R d1 、R e1 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 acyl (-C(O)-R s1 , where R s1 is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted amino C1-C6 acyl group (-NR d2 -C(O)-R s3 , where R d2 is hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, R s3 is an optionally substituted C1-C6 alkyl), X5 is selected from: -C(O)-, -S(O)2-, -S(O)-, where R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl; or When R8, R9 are each independently selected from: optionally substituted C1-C6 alkylcarbonyl, (where X6 is O, S or NR x Where N is the attachment site, R z is an optionally substituted C1-C6 alkyl group, R x is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkylsulfinyl (-S(O)R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkylsulfonyl (-S(O)2R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted di(C1-C6 alkyl)phosphinyl ( where R g 、R h is an optionally substituted C1-C6 alkyl), halogen, or nitro group, X5 is selected from: -NH-, -N(R q )-, where R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl.

3. The compound of claim 1, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The structural formula of the compound is selected from the following: 1) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 If the right Find the definition of either 1 or 2; 2) Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; Preferably, wherein: R1 is selected from a 5-7 membered heteroaromatic ring group, preferably a 5-6 membered heteroaromatic ring group, more preferably a 6 membered heteroaromatic ring group, wherein the above heteroaromatic ring group contains 1-2 heteroatoms, and the heteroatoms are selected from N atoms, O atoms, S atoms (preferably N atoms); the heteroaromatic ring group is optionally substituted by R a 、R b 、R c replaced by; Further preferably, R1 is selected from a pyrimidine ring group, wherein the pyrimidine ring group is optionally substituted by a group R a 、R b 、R c replaced by; Even more preferably, R1 is selected from: Among them, R a 、R b 、R c Independently selected from: hydrogen, C1-C6 alkoxy, C3-C8 cycloalkyl; preferably selected from: hydrogen, methoxy, cyclopropyl; R3 is selected from: hydrogen, C1-C6 alkyl; preferably selected from: hydrogen; R2 is selected from: hydrogen, C1-C6 alkyl; preferably selected from: hydrogen; R8 is selected from: C1-C6 acyl, di(C1-C6 alkyl)phosphinyl, which is unsubstituted or optionally substituted by 1-9 halogen atoms; preferably selected from: acetyl, trifluoroacetyl, dimethylphosphinyl; Alternatively, R2, R8 together with the atoms to which they are attached form Wherein, * indicates the atomic position to which R2 and R8 are connected respectively; Ring B is selected from 6-10 membered aryl, 7-14 membered bicyclic or tricyclic fused heterocyclic group, preferably 6 membered aryl, 7-9 membered bicyclic fused heterocyclic group, wherein the aryl or fused heterocyclic group is optionally substituted by R 41 、R 42 , replaced by R5; Even more preferably, Ring B is selected from R 41 、R 42 Selected from: hydrogen, C1-C6 alkyl; preferably selected from: hydrogen; R5 is selected from: Among them, R m 、R n Each is independently selected from: C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms; preferably selected from: trifluoromethyl, isopropyl; X5 is selected from: -NH-; n1 is selected from 0, 1, 2, 3, 4, preferably 0, 1, more preferably 0; n2 is selected from 0, 1, 2, 3, 4, preferably 0, 1, 2, more preferably 1; and when one of them is 0, the other is not 0; when one is not 0, the other is 0; R 61 、R 71 、R 62 、R 72 , when present, are each independently selected from: hydrogen, C1-C6 alkyl, preferably selected from: Hydrogen, or R 61 With R 71 or R 62 With R 72 Together they form a C3-C8 cycloalkylene subunit, preferably 3) Among them: R1, R2, R8, R9, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 4) Among them: R1, R2, R3, R8, R9, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 5) Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 6) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 7) Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 8) Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 9) Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 10) Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 11) Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 12) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 13) Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 14) Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 15) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 16) Among them: R1, R3, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 17) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2, Preferably, wherein: R1 is selected from a 5-7 membered heteroaromatic ring group, preferably a 5-6 membered heteroaromatic ring group, more preferably a 6 membered heteroaromatic ring group, wherein the above heteroaromatic ring group contains 1-2 heteroatoms, and the heteroatoms are selected from N atoms, O atoms, S atoms (preferably N atoms); the heteroaromatic ring group is optionally substituted by R a 、R b 、R c replaced by; Further preferably, R1 is selected from a pyrimidine ring group, wherein the pyrimidine ring group is optionally substituted by a group R a 、R b 、R c replaced by; Even more preferably, R1 is selected from: Among them, R a 、R b 、R c Independently selected from: hydrogen, C1-C6 alkoxy, C3-C8 cycloalkyl; preferably selected from: hydrogen, methoxy, cyclopropyl; R3 is selected from: hydrogen, C1-C6 alkyl; preferably selected from: hydrogen, methyl; R2 is selected from: hydrogen, C1-C6 alkyl, C1-C6 acyl; preferably selected from: hydrogen, methyl, ethyl, acetyl; R8 is selected from: C1-C6 amide, C1-C6 acyl, C1-C6 alkyl; preferably selected from: amide, acetyl, ethyl; Alternatively, R2, R8 together with the atoms to which they are attached form Wherein, * indicates the atomic position to which R2 and R8 are connected respectively; Ring B is selected from 6-10 membered aryl groups, preferably 6 membered aryl groups, which are optionally substituted by R 41 、R 42 , replaced by R5; Even more preferably, Ring B is selected from R 41 、R 42 Each is independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen; preferably, R 41 、R 42 Each independently selected from: hydrogen; fluorine, methoxy; R5 is selected from: Among them, R m 、R n Each is independently selected from: C1-C6 alkyl which is unsubstituted or optionally substituted by 1-9 halogen atoms; preferably selected from: trifluoromethyl, isopropyl, methyl, ethyl; X5 is selected from: -NH-; n1 is selected from 0, 1, 2, 3, 4, preferably 0, 1, more preferably 0; n2 is selected from 0, 1, 2, 3, 4, preferably 0, 1, 2, more preferably 1; and when one of them is 0, the other is not 0; when one is not 0, the other is 0; R 61 、R 62 、R 71 、R 72 , when present, are each independently selected from: hydrogen, C1-C6 alkyl, preferably selected from: hydrogen; 18) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 19) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 20) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 21) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 22) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 23) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 24) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 25) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 26) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 27) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 28) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 29) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 30) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 31) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 32) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 33) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 34) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 35) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 36) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2; 37) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2; 38) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 39) Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 40) Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 41) Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 42) Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 43) Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 44) Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 45) Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 46) Among them: Ring A, R1, R2, R3, R8, R9, Ring B, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl; 47) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 48) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 49) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As claimed in claim 1, Any of the following definitions: 50) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 51) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 52) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 53) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 54) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 55) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 56) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 57) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 58) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 59) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 60) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 61) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 62) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 63) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 64) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 65) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2; 66) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2; 67) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 68) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 69) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 70) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As claimed in claim 1, Any of the following definitions: 71) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 72) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 73) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 74) Among them: R1, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 75) Among them: R1, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 76) Among them: R1, R2, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 77) Among them: R1, R3, R8, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As claimed in claim 1, Any of the following definitions: 78) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 79) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 80) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 81) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 82) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 83) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 84) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 85) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 86) Where: R1, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 87) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 88) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 89) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 90) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 91) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 92) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 93) Among them: R1, R2, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl; 94) Among them: R1, R2, R3, R8, B ring, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 95) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 96) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 97) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 98) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 99) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 100) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 101) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 102) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 103) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、X5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 104) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 105) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 106) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 107) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 108) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 109) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 110) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 111) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 112) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 113) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2; 114) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2; 115) Among them: Ring A, R1, R2, R3, R8, R9, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 116) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 117) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 118) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 119) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 120) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 121) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 122) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2; 123) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of embodiments 1 and 2; 124) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 125) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 126) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 127) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 128) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 129) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 130) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 131) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 132) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 133) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 134) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 135) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 136) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 137) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 138) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 139) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 140) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; R q Selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio, preferably selected from: optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, more preferably selected from: methyl, ethyl, n-propyl or isopropyl; 141) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 142) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 143) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 144) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 145) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 146) Among them: R1, R2, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 147) Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 148) Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 149) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 150) Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 151) Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 152) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 153) Among them: R1, R3, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2; 154) Among them: R1, R2, R8, R 41 、R 42 、R5、n1、n2、R 61 、R 71 、R 62 、R 72 As defined in any one of claims 1 and 2.

4. The compound of any one of claims 1 to 3, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, in: R1 is selected from: in, R on R1 a 、R b 、R c entirely hydrogen; or R on R1 c is hydrogen, in which case R1 has R a 、R b Two substituents; R a 、R b Independently selected from: C1-C6 alkyl optionally substituted by 5-6-membered aromatic ring group, 5-6-membered heteroaromatic ring group, 5-6-membered saturated or partially unsaturated heterocyclic group, C3-C8 cycloalkyl group, C1-6 alkoxy optionally substituted by 5-6-membered aromatic ring group, 5-6-membered heteroaromatic ring group, 5-6-membered saturated or partially unsaturated heterocyclic group, C3-C8 cycloalkyl group, C1-C6 alkoxy optionally substituted by C1-C6 alkoxy group or one or more halogens.

5. The compound of claim 3, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, For 1) Formula I-A1, 18) Formula I-B1, 19) Formula I-B2, 20) Formula I-B3, 21) Formula I-B4, 22) Formula I-B5, 23) Formula I-B6, 24) Formula I-B7, 25) Formula I-B8, 26) Formula I-B9, 27) Formula I-B10, 28) Formula I-B11, 29) Formula I-B12, 30) Formula I-B13, 31) Formula I-B14, 32) Formula I-B15, 33) Formula I-B16, 34) Formula I-B17, 35) Formula I-B18, 36) Formula I-B19, 37) Formula I-B19-2, 38) Formula I-B1 9-3, 39) Formula I-X1, 40) Formula I-X2, 41) Formula I-X3, 42) Formula I-X4, 43) Formula I-X5, 44) Formula I-X6, 45) Formula I-X7, 46) Formula I-X8, 47) Formula I-AB1, 48) Formula I-AB2, 49) Formula I-AB3, 50) Formula I-AB4, 51) Formula I-AB5, 52) Formula I-AB6, 53) Formula I-AB7, 54) Formula I-AB8, 55) Formula I-AB9, 56) Formula I-AB10, 57) Formula I-AB11, 58) Formula I-AB12, 59) Formula I-AB13, 60 ) Formula I-AB14, 61) Formula I-AB15, 62) Formula I-AB16, 63) Formula I-AB17, 64) Formula I-AB18, 65) Formula I-AB19, 66) Formula I-AB19-2, 67) Formula I-AB19-3, 87) Formula I-AX1, 88) Formula I-AX2, 89) Formula I-AX3, 90) Formula I-AX4, 91) Formula I-AX5, 92) Formula I-AX6, 93) Formula I-AX7, 94) Formula I-AX8, 95) Formula I-BX1, 96) Formula I-BX2, 97) Formula I-BX3, 98) Formula I-BX4, 99 ) formula I-BX5, 100) formula I-BX6, 101) formula I-BX7, 102) formula I-BX8, 103) formula I-BX9, 104) formula I-BX10, 105) formula I-BX11, 106) formula I-BX12, 107) formula I-BX13, 108) formula I-BX14, 109) formula I-BX15, 110) formula I-BX16, 111) formula I-BX17, 112) formula I-BX18, 113) formula I-BX19, 114) formula I-BX19-2, 115) formula I-BX19-3, 116) formula I-ABX1, 117) Formula I-ABX2, 118) Formula I-ABX3, 119) Formula I-ABX4, 120) Formula I-ABX5, 121) Formula I-ABX6, 122) Formula I-ABX7, 123) Formula I-ABX7-2, 124) Formula I-ABX7-3, 125) Formula I-ABX8, 126) Formula I-ABX9, 127) Formula I-ABX10, 128) Formula I-ABX11, 129) Formula I-ABX12, 130) Formula I-ABX13, 131) Formula I-ABX14, 132) Formula I-ABX15, 133) Formula I-ABX16, 134) Formula I-ABX17, 135) Formula I-ABX18, 136) Formula I-ABX19, 137) Formula I-ABX20, 138) Formula I-ABX21, 139) Formula I-ABX22, 140) Formula I-ABX23, wherein: R2 is selected from: C1-C6 alkyl, halogen, cyano; R8 is selected from: optionally substituted C1-C6 alkyl, (where X6 is O, S or NR x Where N is the attachment site, R z is an optionally substituted C1-C6 alkyl group, R x is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkyloxyacyl (-C(O)OR s2 , where R s2 is an optionally substituted C1-C6 alkyl group), an optionally substituted C1-C6 amide group (R s4 -C(O)NR d3 R e3 , where R s4 is absent or optionally substituted C1-C6 alkylene, R d3 、R e3 each independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C2-C8 alkenyl, optionally substituted C2-C8 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C1-C6 alkyloxy, optionally substituted hydroxyC1-C6 alkyl, optionally substituted C1-C6 alkylthio), optionally substituted C1-C6 alkylsulfinyl (-S(O)R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted C1-C6 alkylsulfonyl (-S(O)2R f , where R f is an optionally substituted C1-C6 alkyl), an optionally substituted di(C1-C6 alkyl)phosphinyl ( where R g 、R h is an optionally substituted C1-C6 alkyl group).

6. The compound of any one of claims 1 to 3, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, in: X5 is a direct key; Ring B is a 5-6 membered aromatic ring group or a 5-6 membered heteroaromatic ring group, wherein the 5-6 membered aromatic ring group or the 5-6 membered heteroaromatic ring group is optionally substituted by 1-2 substituents selected from the group consisting of hydrogen, halogen, and alkoxy; R5 is a 5-6 membered heteroaryl group, which is optionally substituted by 2-3 substituents selected from the group consisting of hydrogen, cyano, halogen, C1-C6 alkyl optionally substituted by halogen, C3-C8 cycloalkyl, and 4-15 membered heterocyclyl.

7. The compound of claim 1, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The structural formula of the compound is Formula I-ABX44, in: Q1 is CH or N, Q2 is CH or N, provided that at least one of Q1 and Q2 is N; preferably, Q1 is N, and Q2 is N or CH; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl; preferably, R 10 is H, C1-C4 alkyl or -C(O)-C1-C4 alkyl; preferably, R 10 is H, methyl, ethyl, -C(O)-methyl; more preferably, R 10 is H or methyl; Ring B is selected from phenyl, 6-membered heteroaryl, 7-10-membered bridged heterocyclic group, wherein the 6-membered heteroaryl, 7-10-membered bridged heterocyclic group contains 1-2 N atoms; preferably, Ring B is selected from wherein Q3, Q4, Q5, and Q6 are each independently selected from CH or N, and t is 1 or 2; preferably, Selected from wherein Q3, Q4, Q5, and Q6 are each independently selected from CH or N, preferably, at most one of Q3, Q4, Q5, and Q6 is N, and t is 1 or 2; R1, R2, R8, R 41 、R 42 、R5、n2、R 62 、R 72 As defined in any one of claims 1 and 2; preferably, R1 is selected from Among them, R a 、R b 、R c independently selected from: hydrogen, halogen, cyano, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), -C(O)NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), the C1-C6 alkyl, C2-C8 C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio are optionally substituted with one or more halogen, deuterium or C1-C6 alkyloxy; R a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuterium or C1-4 alkyloxy groups; a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen or C1-C4 alkyl), wherein the C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy is optionally substituted with one or more deuterium or C1-4 alkyloxy groups; a 、R b 、R c Further preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, methoxy, difluoromethoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a 、R b 、R c More preferably, it is selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkyloxy, and C1-C6 haloalkyl; preferably selected from the group consisting of hydrogen, C1-C6 alkyl, and halogen; preferably selected from the group consisting of hydrogen, C1-C4 alkyl, and halogen; more preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; further preferably selected from the group consisting of hydrogen; R8 is selected from: halogen, C1-C6 alkyl, C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl or C3-C8 halocycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 each independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from: R8 is selected from: halogen, C1-C6 alkyl, -NR d1 R e1 (where R d1 、R e1 Each independently selected from H, C1-C6 alkyl, C3-C8 cycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 and the nitrogen atom to which it is attached form a 4-7 membered heterocyclic group); preferably selected from: C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl or C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-6 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Each is independently selected from the group consisting of -C(O)-R s1 (where R s1 C1-C4 alkyl, C1-C4 haloalkyl, C3-C5 cycloalkyl alkyl, C3-C4 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C4 alkyl, C3-C5 cycloalkyl, deuterated C1-C4 alkyl, or R d3 、R e3 Each is independently selected from the group consisting of a 4-5 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, More preferably selected from: acetyl, Alternatively, R2, R8 or R2, R9 together with the atoms to which they are attached form Wherein, * represents the position of the atom to which R2, R8 or R2, R9 are connected; preferably, R2, R8 or R2, R9 together with the atoms to which they are connected form Where * indicates the position of the atom to which R2, R8 or R2, R9 are respectively connected; n2 is 1; R 62 、R 72 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; more preferably selected from: hydrogen, methyl, ethyl, or R 62 With R 72 Together form a C3-C8 cycloalkylene group (preferably a C3-C5 cycloalkylene group) or =O, preferably R 41 and R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; preferably selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxy; preferably selected from: hydrogen, C1-C4 alkoxy, C1-C4 alkyl, halogen, hydroxy; more preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen; R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, deuterated C1-C6 alkyl, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; the 5-6 membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, pyridine ring group, pyrimidine ring group; Preferably, R5 is selected from an optionally substituted 5-membered heteroaryl group, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyloxy, hydroxyl, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from optionally substituted H, C1-C6 alkyl or deuterated C1-C6 alkyl); The 5-membered heteroaryl group is preferably selected from: a pyrrole ring group, a pyrazole ring group, an imidazole ring group; Further preferably, R5 is selected from an optionally substituted 5-membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more C1-C4 alkyl, deuterated C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkyloxy, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C4 alkyl or deuterated C1-C4 alkyl); the 5-membered heteroaryl is preferably selected from: pyrazole ring group, imidazole ring group; More preferably, R5 is selected from: (i) (Preferred ), where R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m 、R n Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m 、R n Selected from: methyl, trideuteromethyl, isopropyl, trifluoromethyl, CH2CF3, methoxy, trideuteromethoxy, -NHCD3; Even more preferably, R5 is selected from: R m1 、R n1 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m1 、R n1 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m1 、R n1 is selected from the group consisting of: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3; further preferably, R m1 、R n1 Selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3; Even more preferably, R5 is selected from: Among them, R m3 、R n3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m3 、R n3 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m3 、R n3 Selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; (ii) Preferred R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3; (iii) (Preferred ), where R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3; More preferably, R5 is selected from: R m1 、R n1 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m1 、R n1 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m1 、R n1 is selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, deuterated methoxy, -NHCD3; further more preferably, R m1 、R n1 is selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3; further more preferably, R m1 Selected from: methyl, methoxy, trideuterated methoxy, -NHCD3, R n1 is trifluoromethyl; or Among them, R m3 、R n3 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m3 、R n3 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, deuterated methyl, deuterated methoxy, -NHCD3; further more preferably, R m3 、R n3 is selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; further more preferably, R m3 Selected from: isopropyl, CH2CF3, trideuterated methyl, R n3 It is trifluoromethyl.

8. The compound of claim 1, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The structural formula of the compound is Formula I-ABX39, Wherein: Q1 is CH or N, Q2 is CH or N, provided that at least one of Q1 and Q2 is N; Q3, Q4, Q5, Q6 are each independently selected from CH or N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl; R1, R2, R8, R 41 、R 42 、R5、n2、R 62 、R 72 As defined in any one of claims 1 and 2.

9. The compound of claim 8, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The structural formula of the compound is Formula I-ABX40, Wherein: Q1 is CH or N, Q2 is CH or N, provided that at least one of Q1 and Q2 is N; Q3, Q4, Q5, Q6 are each independently selected from CH or N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl; R1 is selected from: Among them, R a 、R b 、R c independently selected from: hydrogen, halogen, cyano, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), said C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted with one or more halogen, deuterium or C1-C6 alkyloxy; a 、R b 、R c Preferred H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuterium or C1-4 alkyloxy groups; a 、R b 、R c Further preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, methoxy, difluoromethoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a 、R b 、R c More preferably, it is selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkyloxy, and C1-C6 haloalkyl; preferably selected from the group consisting of hydrogen, C1-C6 alkyl, and halogen; more preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; further preferably selected from the group consisting of hydrogen; R8 is selected from: halogen, C1-C6 alkyl, C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl or C3-C8 halocycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 each independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from: C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl or C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-6 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Each is independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, More preferably selected from: acetyl, Alternatively, R2, R8 or R2, R9 together with the atoms to which they are attached form Wherein, * represents the position of the atom to which R2, R8 or R2, R9 are connected; preferably, R2, R8 or R2, R9 together with the atoms to which they are connected form Where * indicates the position of the atom to which R2, R8 or R2, R9 are respectively connected; R 62 、R 72 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; more preferably selected from: hydrogen, methyl, ethyl, or R 62 With R 72 Together form a C3-C8 cycloalkylene group or =O, preferably R 41 and R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; preferably selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxy; more preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen; R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, deuterated C1-C6 alkyl, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; the 5-6 membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, pyridine ring group, pyrimidine ring group; More preferably, R5 is selected from: (i) (Preferred ), where R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m 、R n Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m 、R n Selected from: methyl, trideuteromethyl, isopropyl, trifluoromethyl, CH2CF3, methoxy, trideuteromethoxy, -NHCD3; Even more preferably, R5 is selected from: R m1 、R n1 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m1 、R n1 is selected from the group consisting of: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3; further preferably, R m1 、R n1 Selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3; Even more preferably, R5 is selected from: Among them, R m3 、R n3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m3 、R n3 Selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; (ii) Preferred , R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 ring atoms selected from N, O or S, wherein the "optionally substituted" means optionally substituted by 1 or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3; (iii) (Preferred ), where R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3.

10. The compound of claim 9, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, having one or more selected from the following: 1) R1 is selected from: in, R a 、R b 、R c independently selected from: H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuteriums; R a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 are independently selected from hydrogen or C1-C4 alkyl), the C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halo Cycloalkyl, C3-C4 haloalkoxy is optionally substituted with one or more deuteriums; R a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R c More preferably, it is selected from the group consisting of: hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; More preferably, R1 is selected from: Among them, R a Selected from: C1-C4 alkyl, C3-C5 cycloalkyl, R b Selected from: hydrogen, R c is selected from: C1-C4 alkyloxy, wherein the C1-C4 alkyloxy is optionally substituted by one or more deuteriums; preferably, R a Selected from: methyl, cyclopropyl, R b Selected from: hydrogen, R c Selected from: methoxy, trideuterated methoxy; or Among them, R a Selected from: hydrogen, R b Selected from: hydrogen, R c Selected from: C1-C4 alkyloxy; preferably, R a Selected from: hydrogen, R b Selected from: hydrogen, R c Selected from: methoxy; or Among them, R a Selected from: hydrogen, cyano, C1-C4 alkyl, R b Selected from: hydrogen, R c Selected from: C1-C4 alkyloxy, C1-C4 alkyl; preferably, R a Selected from: hydrogen, methyl, cyano, R b Selected from: hydrogen, R c Selected from: methoxy, isopropyl; or Among them, R a Selected from: hydrogen, C1-C4 haloalkyl, R b Selected from: hydrogen, R c Selected from: C1-C4 alkyl; preferably, R a Selected from: chlorine, trifluoromethyl, R b Selected from: hydrogen, R c Selected from: isopropyl; or Among them, R a Selected from: hydrogen, C3-C5 cycloalkyl, R b Selected from: hydrogen, R c Selected from: C1-C4 alkyloxy, -C(O)NR d1 R e1 (where R d1 、R e1 are independently selected from hydrogen or C1-C4 alkyl); preferably, R a Selected from: chlorine, cyclopropyl, R b Selected from: hydrogen, R c Selected from: methoxy, -C(O)NHCH3; Still further preferably, R1 is selected from 2) R5 is selected from an optionally substituted 5-membered heteroaryl group, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyloxy, hydroxyl, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from optionally substituted H, C1-C6 alkyl or deuterated C1-C6 alkyl), the 5-membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group; preferably, R5 is selected from optionally substituted 5-membered heteroaryl, the "optionally substituted" means optionally substituted by one or more C1-C4 alkyl, deuterated C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkyloxy, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C4 alkyl or deuterated C1-C4 alkyl), the 5-membered heteroaryl is preferably selected from: pyrazole ring group, imidazole ring group; further preferably, R5 is selected from: R m1 、R n1 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m1 、R n1 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m1 、R n1 is selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, deuterated methoxy, -NHCD3; further more preferably, R m1 、R n1 is selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3; further more preferably, R m1 Selected from: methyl, methoxy, trideuterated methoxy, -NHCD3, R n1 is trifluoromethyl; or Among them, R m3 、R n3 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m3 、R n3 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, deuterated methyl, deuterated methoxy, -NHCD3; further more preferably, R m3 、R n3 is selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; further more preferably, R m3 Selected from: isopropyl, CH2CF3, trideuterated methyl, R n3 is trifluoromethyl; Still more preferably, R5 is selected from:

11. The compound of claim 8, 9 or 10, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, having one or more selected from the following: 1) Q1 is N, Q2 is N or CH; 2) At most one of Q3, Q4, Q5, and Q6 is N; 3) R 10 is H, C1-C4 alkyl or -C(O)-C1-C4 alkyl; preferably, R 10 is H, methyl, ethyl, -C(O)-methyl; more preferably, R 10 is H or methyl; 4) R2 is selected from the group consisting of hydrogen, C1-C4 alkyl, and halogen; preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; and even more preferably H; 5) R8 is selected from: halogen, C1-C6 alkyl, -NR d1 R e1 (where R d1 、R e1 Each independently selected from H, C1-C6 alkyl, C3-C8 cycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group); preferably selected from -C(O)-R s1 (where R s1 C1-C4 alkyl, C3-C5 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C4 alkyl, C3-C5 cycloalkyl, deuterated C1-C4 alkyl, or R d3 、R e3 Each independently selected from the group consisting of a 4-5 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, More preferably selected from: acetyl, 6)R 62 、R 72 Independently selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy; preferably selected from: hydrogen, methyl, ethyl, methoxy; more preferably selected from: hydrogen, methyl, or R 62 With R 72 Together they form a C3-C5 cycloalkylene subunit, preferably 7) R 41 and R 42 Each is independently selected from: hydrogen, C1-C4 alkoxy, C1-C4 alkyl, halogen, hydroxy; preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen.

12. The compound of claim 1, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The structural formula of the compound is Formula I-ABX41, Wherein: Q3, Q4, Q5, Q6 are each independently selected from CH or N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl; R1, R8, R 41 、R 42 、R5、n2、R 62 、R 72 As defined in any one of claims 1 and 2.

13. The compound of claim 12, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The structural formula of the compound is Formula I-ABX42, Wherein: Q3, Q4, Q5, Q6 are each independently selected from CH or N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl; R1 is selected from: Among them, R a 、R b 、R c Independently selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), wherein the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted by one or more halogens; a 、R b 、R c R is preferably selected from H, halogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, methoxyethoxy, trideuterated methoxy, cyclopropyl, and difluorocyclopropyl; a 、R b 、R c More preferably, the group consisting of hydrogen, methyl, isopropyl, methoxy, chlorine, cyclopropyl, trideuterated methoxy; R8 is selected from: halogen, C1-C6 alkyl, C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 each independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl or C3-C8 halocycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); R8 is preferably selected from: C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl or C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-6 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); R8 is more preferably selected from: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, R 62 、R 72 R is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, and amino; 62 、R 72 Preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; More preferably selected from: hydrogen, methyl, ethyl, or R 62 With R 72 Together form a C3-C8 cycloalkylene group or =O, preferably R 41 and R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; preferably selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxy; more preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; the 5-6 membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group, pyridine ring group, pyrimidine ring group; More preferably, R5 is selected from: (i) (Preferred ), where R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3; Even more preferably, R5 is selected from: R m1 、R n1 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m1 、R n1 Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3; Even more preferably, R5 is selected from Among them, R m3 、R n3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidine, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m3 、R n3 Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3; (ii) Preferred R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3; (iii) (Preferred ), where R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3.

14. The compound of claim 12 or 13, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, having one or more of the following: 1) At most one of Q3, Q4, Q5, and Q6 is N; 2) R 10 is H or methyl; 3) R8 is selected from: halogen, C1-C6 alkyl, -NR d1 R e1 (where R d1 、R e1 Each independently selected from H, C1-C6 alkyl, C3-C8 cycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group).

15. The compound of claim 1, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite, or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The structural formula of the compound is Formula I-ABX43, Where: Q1 is CH or N, Q2 is CH or N, provided that at least one of Q1 and Q2 is N; R 10 is H, C1-C6 alkyl or -C(O)-C1-C6 alkyl, and t is 1 or 2; R1, R2, R8, R 41 、R 42 、R5、n2、R 62 、R 72 As defined in any one of claims 1 and 2; Preferably, n2 is 1; R1 is selected from: R1 is preferably Among them, R a 、R b 、R c independently selected from: hydrogen, halogen, cyano, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, -NR d1 R e1 (where R d1 、R e1 Each independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen, C1-C6 alkyl or C3-C8 cycloalkyl), wherein the C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio is optionally substituted by one or more halogen, deuterium or C1-6 alkyloxy; a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 R is independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuterium or C1-4 alkyloxy groups; a 、R b 、R c Further preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, methoxyethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, methoxy, difluoromethoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a 、R b 、R c Still more preferably selected from: hydrogen, methoxy, cyclopropyl; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 alkyloxy, and C1-C6 haloalkyl; preferably selected from the group consisting of hydrogen, C1-C6 alkyl, and halogen; more preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; further preferably selected from the group consisting of hydrogen; R8 is selected from: halogen, C1-C6 alkyl, C1-C6 alkyloxy, -NR d1 R e1 (where R d1 、R e1 Each one alone independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl or C3-C8 halocycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 each independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from: C1-C6 alkyl, -C(O)-R s1 (where R s1 is C1-C6 alkyl or C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl, C3-C6 cycloalkyl or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-6 membered heterocyclic group), -S(O)R f (where R f is C1-C6 alkyl), -S(O)2R f (where R f is C1-C6 alkyl), (where R g 、R h is C1-C6 alkyl); preferably selected from -C(O)-R s1 (where R s1 C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C8 halocycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Each is independently selected from the group consisting of a 4-7 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, cyclopropylacetyl, methylsulfonyl, dimethylphosphinyl, diisopropylphosphinyl, methyl, ethyl, More preferably selected from: acetyl, More preferably selected from: acetyl; R 62 、R 72 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxy, halogen, nitro, cyano, amino; preferably selected from: hydrogen, methyl, ethyl, methoxy, ethoxy, hydroxy, amino, F, Cl, Br; more preferably selected from: hydrogen, methyl, ethyl, or R 62 With R 72 Together form a C3-C8 cycloalkylene group or =O, preferably R 41 and R 42 Each is independently selected from: H, C1-C6 alkyl, halogen, C1-C6 alkoxy, hydroxy, C1-C6 haloalkyl, C3-C6 cycloalkyl; preferably selected from: hydrogen, C1-C6 alkoxy, C1-C6 alkyl, halogen, hydroxy; more preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen; R5 is selected from optionally substituted phenyl or optionally substituted 5-6 membered heteroaryl, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, deuterated C1-C6 alkyl, hydroxy, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C6 alkyl, C3-C8 cycloalkyl or deuterated C1-C6 alkyl), oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl, and the oxetanyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, morpholinyl is optionally substituted with 1-2 substituents selected from deuterium, halogen, C1-C6 alkyl, C1-C6 haloalkyl; The 5-6 membered heteroaryl group is preferably selected from: a pyrrole ring group, a pyrazole ring group, an imidazole ring group, a pyridine ring group, and a pyrimidine ring group; More preferably, R5 is selected from: (i) (Preferred ), where R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; preferably, R m 、R n Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m 、R n Selected from: methyl, trideuteromethyl, isopropyl, trifluoromethyl, CH2CF3, methoxy, trideuteromethoxy, -NHCD3; Even more preferably, R5 is selected from: R m1 、R n1 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m1 、R n1 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m1 、R n1 is selected from the group consisting of: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3; further preferably, R m1 、R n1 Selected from: methyl, trifluoromethyl, methoxy, deuterated methoxy, -NHCD3; Even more preferably, R5 is selected from: Among them, R m3 、R n3 independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m3 、R n3 Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methyl, deuterated methoxy, -NHCD3; more preferably, R m3 、R n3 is selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; further more preferably, R m3 、R n3 Selected from: trifluoromethyl, isopropyl; (ii) Preferred R m 、R n independently selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m 、R n Selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m 、R n Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidinyl, deuterated methoxy, -NHCD3; (iii) (Preferred ), where R m Selected from: hydrogen, halogen, C1-C6 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, C1-C6 alkyloxy, hydroxy C1-C6 alkyl, C1-C6 alkylthio, C1-C6 haloalkyl, C1-C6 haloalkoxy, C1-C6 halocycloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, deuterated C1-C6 alkyl), cyano, carboxyl, optionally substituted 4-7 membered heterocyclic group containing 1-2 selected from N, O or S as ring atoms, wherein the "optionally substituted" means optionally substituted by one or more halogen atoms, C1-C6 alkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, hydroxyl, C1-C6 alkylthio, nitro, amino, cyano, carboxyl, deuterium; preferably, R m Selected from: hydrogen, C1-C6 alkane alkyl, C1-C6 alkoxy, halogen, C3-C8 cycloalkyl, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl), oxetanyl, azetidinyl, 1-methylazetidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl; more preferably, R m Selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, morpholinyl, oxetanyl, 1-methylazetidine, deuterated methoxy, -NHCD3.

16. The compound of claim 15, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, having one or more selected from the following: 1) R1 is selected from: in, R a 、R b 、R c independently selected from: H, halogen, cyano, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen or C1-C6 alkyl), wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyloxy, C1-C6 haloalkyl, C3-C6 halocycloalkyl, C3-C6 haloalkoxy is optionally substituted with one or more deuteriums; R a 、R b 、R c Preferably selected from H, halogen, cyano, C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy, -C(O)NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen or C1-C4 alkyl), wherein the C1-C4 alkyl, C3-C5 cycloalkyl, C1-C4 alkyloxy, C1-C4 haloalkyl, C3-C4 halocycloalkyl, C3-C4 haloalkoxy is optionally substituted with one or more deuteriums; R a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, fluorine, chlorine, cyano, isopropyl, methyl, ethyl, trifluoromethyl, methoxy, difluoromethoxy, ethoxy, trideuteromethoxy, cyclopropyl, difluorocyclopropyl, -C(O)NHCH3; a 、R b 、R c More preferably, R is selected from the group consisting of hydrogen, methyl, isopropyl, methoxy, chlorine, cyano, cyclopropyl, trideuteromethoxy, trifluoromethyl, -C(O)NHCH3; a Preferably selected from: cyclopropyl, R b Preferably selected from: hydrogen, R c Preferably selected from: methoxy; More preferably, R1 is selected from: 2) R5 is selected from an optionally substituted 5-membered heteroaryl group, wherein the "optionally substituted" means optionally substituted with one or more halogen atoms, C1-C6 alkyl, deuterated C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyloxy, hydroxyl, amino, cyano, carboxyl, deuterated, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each independently selected from optionally substituted H, C1-C6 alkyl or deuterated C1-C6 alkyl), the 5-membered heteroaryl is preferably selected from: pyrrole ring group, pyrazole ring group, imidazole ring group; preferably, R5 is selected from optionally substituted 5-membered heteroaryl, the "optionally substituted" means optionally substituted by one or more C1-C4 alkyl, deuterated C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkyloxy, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 Each is independently selected from optionally substituted H, C1-C4 alkyl or deuterated C1-C4 alkyl), the 5-membered heteroaryl is preferably selected from: pyrazole ring group, imidazole ring group; further preferably, R5 is selected from: R m1 、R n1 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen Halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m1 、R n1 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m1 、R n1 is selected from: H, methyl, trifluoromethyl, isopropyl, methoxy, dimethylamino, deuterated methoxy, -NHCD3; further more preferably, R m1 、R n1 is selected from: methyl, trifluoromethyl, methoxy, trideuterated methoxy, -NHCD3; further more preferably, R m1 Selected from: methyl, methoxy, trideuterated methoxy, -NHCD3, R n1 is trifluoromethyl; or Among them, R m3 、R n3 Independently selected from: hydrogen, C1-C6 alkyl, C1-C6 alkoxy, halogen, C1-C6 haloalkyl, deuterated C1-C6 alkyl, deuterated C1-C6 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C6 alkyl, deuterated C1-C6 alkyl); preferably, R m3 、R n3 Selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, deuterated C1-C4 alkyl, deuterated C1-C4 alkoxy, -NR d1 R e1 (where R d1 、R e1 are each independently selected from hydrogen, C1-C4 alkyl, deuterated C1-C4 alkyl); more preferably, R m3 、R n3 is selected from the group consisting of: H, methyl, trifluoromethyl, trifluoroethyl, isopropyl, methoxy, dimethylamino, deuterated methyl, deuterated methoxy, -NHCD3; further more preferably, R m3 、R n3 is selected from: trifluoromethyl, isopropyl, CH2CF3, trideuterated methyl; further more preferably, R m3 Selected from: isopropyl, CH2CF3, trideuterated methyl, R n3 is trifluoromethyl; Still more preferably, R5 is selected from:

17. The compound of claim 15 or 16, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, having one or more selected from the following: 1) Q1 is N, Q2 is N or CH; 2) R 10 is H, C1-C4 alkyl or -C(O)-C1-C4 alkyl; preferably, R 10 is H, methyl, ethyl, -C(O)-methyl; more preferably, R 10 is H or methyl; 3) R2 is selected from the group consisting of hydrogen, C1-C4 alkyl, and halogen; preferably selected from the group consisting of hydrogen, methyl, ethyl, isopropyl, fluorine, and chlorine; further preferably selected from the group consisting of hydrogen and methyl; and even more preferably H; 4) R8 is selected from: halogen, C1-C6 alkyl, -NR d1 R e1 (where R d1 、R e1 Each independently selected from H, C1-C6 alkyl, C3-C8 cycloalkyl), -C(O)-R s1 (where R s1 C1-C6 alkyl, C3-C6 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, deuterated C1-C6 alkyl, or R d3 、R e3 Together with the nitrogen atom to which it is attached, it forms a 4-7 membered heterocyclic group); preferably selected from -C(O)-R s1 (where R s1 C1-C4 alkyl, C3-C5 cycloalkyl), -C(O)NR d3 R e3 (where R d3 、R e3 are each independently selected from hydrogen, C1-C4 alkyl, C3-C5 cycloalkyl, deuterated C1-C4 alkyl, or R d3 、R e3 Each independently selected from the group consisting of a 4-5 membered heterocyclic group formed together with the nitrogen atom to which it is attached); more preferably selected from the group consisting of: acetyl, More preferably selected from: acetyl, 5)R 62 、R 72 Independently selected from: hydrogen, C1-C4 alkyl, C1-C4 alkoxy; preferably selected from: hydrogen, methyl, ethyl, methoxy; more preferably selected from: hydrogen, methyl, or R 62 With R 72 Together they form a C3-C5 cycloalkylene subunit, preferably 6)R 41 and R 42 Each is independently selected from: hydrogen, C1-C4 alkoxy, C1-C4 alkyl, halogen, hydroxy; preferably selected from: hydrogen, methoxy, methyl, chlorine, fluorine, hydroxy; more preferably selected from: hydrogen; 7)n is 1.

18. The compound of any one of claims 1 to 17, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The compound is selected from: Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6, Compound 7, Compound 8, Compound 9, Compound 10, Compound 11, Compound 12, Compound 13, Compound 14, Compound 15, Compound 16, Compound 17, Compound 18, Compound 19, Compound 20, Compound 21, Compound 22, Compound 23, Compound 24, Compound 25, Compound 26, Compound 27, Compound 28, Compound 29, Compound 30, Compound 31, Compound 32, Compound 33, Compound 34, Compound 35, Compound 36, Compound 37, Compound 38, Compound 39, Compound 40, Compound 41, Compound 42, Compound 43, Compound 44, compound 45, compound 46, compound 47, compound 48, compound 49, compound 50, compound 51, compound 52, compound 53, compound 54, compound 55, compound 56, compound 57, compound 58, compound 59, compound 60, compound 61, compound 62, compound 63, compound 64, compound 65, compound 66, compound 67, compound 68, compound 69, compound 70, compound 71, compound 72, compound 73, compound 74, compound 75, compound 76, compound 77, compound 78, compound 79, compound 80, compound 81, compound 82, compound 83, compound 84, compound 85 5. Compound 86, Compound 87, Compound 88, Compound 89, Compound 90, Compound 91, Compound 92, Compound 93, Compound 94, Compound 95, Compound 96, Compound 97, Compound 98, Compound 99, Compound 100, Compound 101, Compound 102, Compound 103, Compound 104, Compound 105, Compound 106, Compound 107, Compound 108, Compound 109, Compound 110, Compound 111, Compound 112, Compound 113, Compound 114, Compound 115, Compound 116, Compound 117, Compound 118, Compound 119, Compound 120, Compound 121, Compound 122, Compound Compound 123, compound 124, compound 125, compound 126, compound 127, compound 128, compound 129, compound 130, compound 131, compound 132, compound 133, compound 134, compound 135, compound 136, compound 137, compound 138, compound 139, compound 140, compound 141, compound 142, compound 143, compound 144, compound 145, compound 146, compound 147, compound 148, compound 149, compound 150, compound 151, compound 152, compound 153, compound 154, compound 155, compound 156, compound 157, compound 158,Compound 159, Compound 160, Compound 161, Compound 162, Compound 163, Compound 164, Compound 165, Compound 166, Compound 167, Compound 168, Compound 169, Compound 170, Compound 171, Compound 172, Compound 173, Compound 174, Compound 175, Compound 176, Compound 177, Compound 178, Compound 179, Compound 180, Compound 181, Compound 182, Compound 183, Compound 184, Compound 185, compound 186, compound 187, compound 188, compound 189, compound 190, compound 191, compound 192, compound 193, compound 194, compound 195, compound 196, compound 197, compound 198, compound 199, compound 200, compound 201, compound 202, compound 203, compound 204, compound 205, compound 206, compound 207, compound 208, compound 209, compound 210, compound 211, compound 212, compound 213, compound 214, compound 215, compound Compound 216, compound 217, compound 218, compound 219, compound 220, compound 221, compound 222, compound 223, compound 224, compound 225, compound 226, compound 227, compound 228, compound 229, compound 230, compound 231, compound 232, compound 233, compound 234, compound 235, compound 236, compound 237, compound 238, compound 239, compound 240, compound 241, compound 242, compound 243, compound 244, compound 245, compound 246; Preferably, the compound is selected from: Compound 1, Compound 2, Compound 3, Compound 4, Compound 6, Compound 7, Compound 9, Compound 12, Compound 13, Compound 14, Compound 15, Compound 16, Compound 17, Compound 18, Compound 48, Compound 49, Compound 50, Compound 51, Compound 109, Compound 112, Compound 116, Compound 119, Compound 120, Compound 155, Compound 156, Compound 157, Compound 158, Compound 174, Compound 198, Compound 199, Compound 206, Compound 207, Compound 208, Compound 236, Compound 237, Compound 239, Compound 240, Compound 241, Compound 242, Compound 243, Compound 244, Compound 245; Further preferably, the compound is selected from compound 1, compound 2, compound 3, compound 4, compound 6, compound 7, compound 9, compound 12, compound 13, compound 14, compound 15, compound 16, compound 17, compound 18, compound 48, compound 49, compound 50, compound 51, compound 109, compound 112, compound 116, compound 119, compound 120, compound 155, compound 156, compound 157, compound 158, compound 198, compound 199, compound 206, compound 207, compound 208, compound 236, compound 237, compound 239, compound 240, and compound 241; Or further preferably, the compound is selected from Compound 242, Compound 243, Compound 244, and Compound 245.

19. The compound of any one of claims 1 to 17, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound), or prodrug thereof, wherein: The compound is selected from: 1) Compound 1, Compound 2, Compound 3, Compound 4, Compound 5, Compound 6, Compound 7, Compound 8, Compound 9, Compound 10, Compound 11, Compound 12, Compound 13, Compound 14, Compound 15, Compound 16, Compound 17, Compound 18, Compound 19, Compound 20, Compound 21, Compound 22, Compound 23, Compound 24, Compound 25, Compound 26, Compound 27, Compound 28, Compound 29, Compound 30, Compound 31, Compound 32, Compound 33, Compound 34, Compound 35, Compound 36, Compound 37, Compound 38, Compound 39, Compound 40, Compound 41 1. Compound 42, Compound 43, Compound 44, Compound 45, Compound 46, Compound 47, Compound 48, Compound 49, Compound 50, Compound 51, Compound 52, Compound 53, Compound 54, Compound 55, Compound 56, Compound 57, Compound 58, Compound 59, Compound 60, Compound 61, Compound 62, Compound 63, Compound 64, Compound 65, Compound 66, Compound 67, Compound 68, Compound 69, Compound 70, Compound 71, Compound 72, Compound 73, Compound 74, Compound 75, Compound 76, Compound 77, Compound 78, Compound 79, Compound 80, Compound Compound 81, Compound 82, Compound 83, Compound 84, Compound 85, Compound 86, Compound 87, Compound 88, Compound 89, Compound 90, Compound 91, Compound 92, Compound 93, Compound 94, Compound 95, Compound 96, Compound 97, Compound 98, Compound 99, Compound 100, Compound 101, Compound 102, Compound 103, Compound 104, Compound 105, Compound 106, Compound 107, Compound 108, Compound 109, Compound 110, Compound 111, Compound 112, Compound 113, Compound 114, Compound 115, Compound 116, Compound 117 , compound 118, compound 119, compound 120, compound 121, compound 122, compound 123, compound 124, compound 125, compound 126, compound 127, compound 128, compound 129, compound 130, compound 131, compound 132, compound 133, compound 134, compound 135, compound 136, compound 137, compound 138, compound 139, compound 140, compound 141, compound 142, compound 143, compound 144, compound 145, compound 146, compound 147, compound 148, compound 149, compound 150, compound 151 , compound 152, compound 153, compound 154, compound 155, compound 156, compound 157, compound 158, compound 159, compound 160, compound 161, compound 162, compound 163, compound 164, compound 165, compound 166, compound 167, compound 168, compound 169, compound 170, compound 171, compound 172, compound 173, compound 174, compound 175, compound 176, compound 177, compound 178, compound 179, compound 180, compound 181, compound 182, compound 183, compound 184, compound 185 , compound 186, compound 187, compound 188, compound 189, compound 190, compound 191, compound 192, compound 193, preferably, the compound is selected from compound 1, compound 2, compound 3, compound 4, compound 6, compound 7, compound 9, compound 12, compound 13, compound 14, compound 15, compound 16, compound 17, compound 18, compound 48, compound 49, compound 50, compound 51, compound 109, compound 112, compound 116, compound 119, compound 120, compound 155, compound 156, compound 157, compound 158, compound 174; or 2) Compound 194, Compound 195, Compound 196, Compound 197, Compound 198, Compound 199, Compound 200, Compound 201, Compound 202, Compound 203, Compound 204, Compound 205, Compound 206, Compound 207, Compound 208, Compound 209, Compound 210, Compound 211, Compound 212, Compound 213, Compound 214, Compound 215, Compound 216, Compound 217, Compound 218, Compound 219, Compound 220, Compound 221, Compound 222, Compound 2 23, compound 224, compound 225, compound 226, compound 227, compound 228, compound 229, compound 230, compound 231, compound 232, compound 233, compound 234, compound 235, compound 236, compound 237, compound 238, compound 239, compound 240, compound 241. Preferably, the compound is selected from compound 198, compound 199, compound 206, compound 207, compound 208, compound 236, compound 237, compound 239, compound 240, compound 241; or 3) Compound 242, Compound 243, Compound 244, Compound 245, Compound 246. Preferably, the compound is selected from Compound 242, Compound 243, Compound 244, and Compound 245.

20. A pharmaceutical composition comprising the compound of any one of claims 1 to 19, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound) or prodrug thereof, and optionally a pharmaceutically acceptable excipient.

21. Use of the compound of any one of claims 1 to 19, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, N-oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotopically labeled compound (preferably a deuterated compound), or prodrug thereof, or the pharmaceutical composition of claim 20, in the preparation of a medicament for treating and / or preventing a disease or condition associated with the regulation of ubiquitin-specific protease 1 (USP1); Preferably, the disease or condition associated with USP1 regulation is a cancer with a defect in the DNA damage repair pathway or a cancer with a defect in homologous recombination; Preferably, the disease or condition associated with USP1 regulation is a tumor with a BRCA1 / 2 mutation, a tumor with an ATM mutation, a tumor with an ATR mutation, a tumor resistant to PARP inhibitors, a tumor with a P53 mutation, or a tumor with two or more mutations simultaneously; Preferably, the disease or disorder associated with USP1 regulation is cancer comprising cancer cells with elevated levels of RAD18; Preferably, the disease or condition associated with USP1 regulation is blood cancer, lymphoma, bone cancer (including osteosarcoma and chondrosarcoma), brain cancer (including glioma, glioblastoma, astrocytoma, medulloblastoma and meningioma), soft tissue cancer (including rhabdomyomas and sarcomas), kidney cancer, bladder cancer, skin cancer (including melanoma), lung cancer (including non-small cell lung cancer), colon cancer, uterine cancer, nervous system cancer, head and neck cancer, pancreatic cancer, cervical cancer, ovarian cancer, peritoneal cancer, endometrial cancer, breast cancer (including triple-negative breast cancer), diabetes.

22. A pharmaceutical combination comprising: (1) the compound according to any one of claims 1 to 19, or the enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite or pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably deuterated) or prodrug thereof, or the pharmaceutical composition according to claim 20; (2) other anti-tumor drugs; Preferably, the other anti-tumor drug is a DNA damaging agent, such as actinomycin, anfloxacin, anthracycline antibiotics, bleomycin, carbosulfan, camptothecin, carboplatin, chloramphenicol, cisplatin, cyclophosphamide, cytotoxin, daunorubicin, doxorubicin, epirubicin, hexamethylmelamine oxaliplatin, ifosfamide, melphalan, pholuramide, mitomycin, mitoxantrone, nitrosoureas, prikamycin, procarbazine, paclitaxel, docetaxel, teniposide, triethylenethiophosphoramide and etoposide; or the DNA damaging agent is a biotherapeutic agent, such as rinterferon-A2A, RNTERFERON-OI2B, RINTERLEUKIN-2, RG-CSF, RGM-CSF and erythropoietin; or Preferably, the other anti-tumor drug is a reversible DNA binding agent, such as tobetan hydrochloride, irinotecan (CPT11-camptothecin), diatomaceous earth, itanotecan, nalidixic acid, TAS-103, etoposide, acridines (such as ansacrine, aminoacridine), actinomycins (such as actinomycin D), anthracyclines (such as doxorubicin, daunorubicin), diphenylacetylene, XR11576 / MLN576, benzopyridindole, mitoxantrone, AQ4, etoposide, teniposide, epipodophyllotoxin and double intercalating agents such as treocitin A and echinomycin; or Preferably, the other anti-tumor drug is a DNA alkylating agent, such as sulfur mustard, nitrogen mustard (such as methylchloroethylamine), chloramphenicol, melphalan, ethyleneimine (such as triethylenemethylamine, quinolone, diazinon), methyl methanesulfonate, butylsulfonamide, CC-1065, multicarboxylic acid (such as multicarboxylic acid A, multicarboxylic acid SA), metabolically activated alkylating agents such as nitrosoureas (such as carmustine, lomustine, (2-chloroethyl) nitrosourea), triazine anti-tumor drugs such as triazinoimidazole (such as dacarbazine), mitomycin C, lenamycin; or Preferably, the other anti-tumor drug is a DNA strand breaking agent, such as doxorubicin and daunorubicin (which are also reversible DNA binding agents), other anthracycline antibiotics, bleomycin, thiazolinone, enediyne anti-tumor antibiotics, such as neocarbazine, espamycin, calicheamicin, dynemycin A, hydracic acid, C-1027, N1999A2, espamycin, zenastatin; or Preferably, the other anti-tumor drug is a DNA replication disruptor, such as 5-fluorodeoxyuridine (floxuridine); or Preferably, the other anti-tumor drug is an antibody, such as a monoclonal antibody, preferably, the monoclonal antibody includes trastuzumab (e.g., anti-ErbB2 / HER2 for breast cancer), cetuximab (e.g., anti-ErbBL / EGFR for colorectal cancer) and bevacizumab (e.g., anti-VEGF for colorectal cancer, breast cancer and lung cancer), a multi-target inhibitor, such as a solution that inhibits the TK activity of VEGFR, PDGFR and FGFR; or Preferably, the other anti-tumor drug is a proteasome inhibitor, such as bortezomib.

23. Use of the pharmaceutical combination of claim 22 in the preparation of a medicament for treating a tumor or cancer, preferably, the tumor and cancer are selected from the group consisting of: adrenocortical carcinoma, AIDS-related lymphoma, AIDS-related malignant tumors, anal cancer, cerebellar astrocytoma, extrahepatic bile duct carcinoma, bladder cancer, osteosarcoma / malignant fibrous histiocytoma, brain stem glioma, ependymoma, visual pathway and hypothalamic glioma, breast cancer, bronchial adenoma / carcinoid, carcinoid tumor, gastrointestinal carcinoid tumor, adrenocortical carcinoma, pancreatic islet cell carcinoma, primary central nervous system lymphoma, cerebellar astrocytoma, cervical cancer, chronic lymphocytic leukemia, Chronic myeloid leukemia, clear cell sarcoma of the tendon sheath, colon cancer, colorectal cancer, cutaneous T-cell lymphoma, endometrial cancer, epididymal tumor, esophageal cancer, Ewing's sarcoma / tumor family, extracranial germ cell tumor, extragerm cell tumor, extrahepatic bile duct cancer, eye cancer (including intraocular melanoma and retinoblastoma), gallbladder cancer, gastrointestinal carcinoid tumor, ovarian germ cell tumor, gestational trophoblastic tumor, hairy cell leukemia, head and neck cancer, Hodgkin's disease, hypopharyngeal cancer, hypothalamic and visual pathway glioma, Kaposi's sarcoma, laryngeal cancer, acute lymphoblastic leukemia, acute myeloid leukemia, liver cancer, non-small cell lung cancer Cell lung cancer, small cell lung cancer, non-Hodgkin's lymphoma, Waldenstrom's macroglobulinemia, malignant thymoma, medulloblastoma, Merkel cell carcinoma, metastatic primary squamous cell carcinoma, multiple endocrine neoplasia syndrome, multiple myeloma / plasmacytoma, fungal disease, myelodysplastic syndrome, chronic myeloid leukemia, myeloid leukemia, multiple myeloma, myeloproliferative disorders, nasal cavity and paranasal sinus cancer, nasopharyngeal cancer, neuroblastoma, oral cavity cancer, oral cavity and lip cancer, oropharyngeal cancer, osteosarcoma / malignant fibrous histiocytoma of bone, ovarian cancer, ovarian low malignant potential tumor, pancreatic cancer, paranasal sinus and nasal cancer Cavity cancer, parathyroid cancer, penile cancer, pheochromocytoma, pituitary tumor, thoracic pulmonary blastoma, prostate cancer, rectal cancer, renal cell (kidney) cancer, transitional cell cancer (such as renal pelvis and ureter), rhabdomyosarcoma, salivary gland cancer, malignant fibrous histiocytoma, including bone and soft tissue sarcoma, Sezary syndrome, skin cancer, small intestine cancer, gastric cancer, supradental primitive neuroectodermal and pineal gland tumors, cutaneous T-cell lymphoma, testicular cancer, malignant thymoma, thyroid cancer, urethral cancer, uterine sarcoma, vaginal cancer, vulvar cancer and Wilms' tumor, anaplastic large cell lymphoma, central nervous system cancer, mesothelioma and melanoma and combinations thereof.

24. A pharmaceutical combination comprising: (1) a compound according to any one of claims 1 to 19, or an enantiomer, diastereomer, racemate, tautomer, stereoisomer, geometric isomer, nitrogen oxide, metabolite thereof, or a pharmaceutically acceptable salt, ester, solvate, hydrate, isotope-labeled compound (preferably a deuterated compound) or prodrug thereof, or a pharmaceutical composition according to claim 20, (2) one or more selected from the following: a PARP inhibitor, an ATM mutation inhibitor, an ATR mutation inhibitor, a P53 mutation modulator, a wee1 inhibitor; Preferably, the PARP inhibitor is selected from: olaparib, niraparib, talazoparib, rucaparib, fuzuloparib, senaparib, veliparib, BGP-15; the ATM inhibitor is selected from: AZD-1390, M-4076, XRD-0394; the ATR inhibitor is selected from: M1774; the P53 agent is selected from: PC14586; the Wee1 inhibitor is selected from: ZN-C3, AZD1775, IMP-7068, SY-4835, MK-1775.

25. Use of the pharmaceutical combination according to claim 24 in the preparation of a medicament for treating tumors or cancers, Preferably, the tumor or cancer is a DNA damage repair pathway defective cancer or a homologous recombination defective cancer; Preferably, the tumor or cancer is a BRCA1 / 2 mutated tumor, an ATR mutated tumor, an ATM mutated tumor, a P53 mutated tumor, or a tumor with two or more mutations simultaneously; Preferably, the tumor or cancer is a PARP inhibitor-resistant or refractory cancer; Preferably, the tumor or cancer is a cancer comprising cancer cells with elevated levels of RAD51; Preferably, the tumor or cancer is a blood cancer, a lymphoma, a bone cancer (including osteosarcoma and chondrosarcoma), a brain cancer (including glioma, glioblastoma, astrocytoma, medulloblastoma and meningioma), a soft tissue cancer (including rhabdomyomas and sarcomas), a kidney cancer, a bladder cancer, a skin cancer (including melanoma), a lung cancer (including non-small cell lung cancer), a colon cancer, a uterine cancer, a nervous system cancer, a head and neck cancer, a pancreatic cancer, a cervical cancer, an ovarian cancer, a peritoneal cancer, an endometrial cancer, a breast cancer (including triple-negative breast cancer).

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