Scanning assembly and method for photoheredity and magnetic resonance combined research

Abstract

The embodiment of the invention provides a scanning assembly and method for photogenetics and magnetic resonance combined research. The scanning assembly comprises a magnetic resonance coil and a circuit board fixing device. The magnetic resonance coil comprises a coil body and a circuit board. The coil body is used for being fixed to a preset part of the target object; the magnetic resonance coil is used for acquiring a magnetic resonance signal of the preset part, and the coil body is detachably connected with the circuit board; the circuit board fixing device is used for fixing the circuit board.

Description

Technical Field

[0001] This specification relates to the field of magnetic resonance scanning, and particularly to a scanning component and method for combined optogenetic and magnetic resonance research. Background Art

[0002] Optogenetics, also known as optogenetic gene engineering, uses light-sensitive channel proteins to control a specific type of neuron at the microsecond level. When neurons are irradiated with light of a specific wavelength, the light-sensitive ion channels on the cell membrane will accelerate the exchange of cations and anions between the cell and the extracellular region. Using an optogenetic system, researchers can perform visible light stimulation on specific neuron populations, and thus study the effects of different neurons on behavior and cognition by adjusting the parameters of the light stimulation. This technology has a wide range of applications in neuroscience research, such as exploring neural circuits, memory, and learning processes.

[0003] Optogenetic research is usually combined with optogenetic manipulation techniques and neuroimaging techniques (such as magnetic resonance imaging technology) to study the functions of neuronal activities and connections. In the combined research of optogenetics and magnetic resonance, magnetic resonance scanning can be used to record and analyze the changes in brain activity of animals or humans after light stimulation, providing high-resolution brain structure and function information.

[0004] In the combined research of optogenetics and magnetic resonance using a single-loop coil, three types of coils can be selected: optogenetic coil, cryogenic coil, and single-loop coil. The optogenetic coil has fixed holes and needs to be customized. In the optogenetic experiment of awake mice, it is impossible to avoid the problem of signal-to-noise ratio loss caused by the fitting interference due to mouse brain fixation and fiber optic fixation; the cryogenic coil has a high signal-to-noise ratio and can compensate for the problem of signal-to-noise ratio loss caused by the fitting interference due to mouse brain fixation and fiber optic fixation, but the purchase cost is high and the operation workflow is cumbersome; the single-loop coil is simple and flexible to operate and has a relatively low cost, but in the optogenetic experiment of awake mice, it is impossible to avoid the problem of signal-to-noise ratio loss caused by the fitting interference due to mouse brain fixation and fiber optic fixation.

[0005] In the combined research of optogenetics and magnetic resonance based on the reception of a single-loop coil, the annular structure (i.e., the coil body) of the magnetic resonance coil is usually pre-welded to the circuit board. During the experiment, it is difficult to install the magnetic resonance coil on the target object, and it is difficult to avoid the problem of reduced signal-to-noise ratio of the magnetic resonance image caused by the excessive distance between the magnetic resonance coil and the target object. Especially when conducting research on awake mice, the fixation of the mouse brain and the fixation of the optogenetic fiber will interfere with the fixation of the magnetic resonance receiving coil, and this problem is more prominent.

[0006] Therefore, it is necessary to propose a scanning component and method for combined optogenetic and magnetic resonance research to better achieve magnetic resonance scanning for optogenetic research of awake mice based on the reception of a single-loop coil. Summary of the Invention

[0007] One or more embodiments of this specification provide a scanning component for combined optogenetic and magnetic resonance research. The scanning component includes: a magnetic resonance coil and a circuit board fixing device; the magnetic resonance coil includes a coil body and a circuit board; the coil body is used to be fixed to a preset part of the target object; the magnetic resonance coil is used to acquire magnetic resonance signals of the preset part, and the coil body and the circuit board are detachably connected; the circuit board fixing device is used to fix the circuit board.

[0008] In some embodiments, the detachable connection between the coil body and the circuit board includes: when the coil body is fixed to the preset part of the target object, the coil body and the circuit board are not connected; when performing magnetic resonance scanning, the coil body and the circuit board are connected.

[0009] In some embodiments, when the coil body is fixed to the preset part of the target object, the coil body fits to the preset part.

[0010] In some embodiments, the coil body and the circuit board are detachably connected by a buckle.

[0011] In some embodiments, the magnetic resonance coil is a single-loop coil, and the circuit board is connected to the coil body through two contact points.

[0012] In some embodiments, the coil body is used to be fixed to the preset part of the target object through dental cement; the target object is a mouse; the preset part is the brain of the mouse.

[0013] In some embodiments, the scanning component further includes a target object fixing device, and the target object fixing device is used to fix the target object; the circuit board fixing device is fixed on the target object fixing device.

[0014] One or more embodiments of this specification provide a scanning method for combined optogenetic and magnetic resonance research. The method includes: fixing a coil body and an optical fiber head to a preset part of a target object; connecting the coil body to a circuit board; and acquiring magnetic resonance signals of the preset part based on the coil body and the circuit board.

[0015] In some embodiments, the fixing the coil body and the optical fiber head to the preset part of the target object includes: fixing the coil body to the preset part of the target object through dental cement; and implanting the optical fiber head into the preset part and fixing it through the dental cement; the target object is a mouse; the preset part is the brain of the mouse.

[0016] In some embodiments, fixing the coil body and the optical fiber head to a preset part of the target object includes: attaching the coil body to the preset part.

[0017] One or more embodiments of this specification provide a method for fixing a magnetic resonance coil. The method is performed using the scanning component described in any of the above embodiments. The method includes: first fixing the coil body to a preset part of the target object; then connecting the coil body to the circuit board.

[0018] One or more embodiments of this specification provide a magnetic resonance imaging system. The magnetic resonance imaging system includes: a scanning component, and the scanning component includes: a magnetic resonance coil and a circuit board fixing device; the magnetic resonance coil includes a coil body and a circuit board; the coil body is used to be fixed to a preset part of the target object; the circuit board fixing device is used to fix the circuit board; the scanning component further includes a target object fixing device, and the target object fixing device is used to fix the target object; the circuit board fixing device is fixed on the target object fixing device.

[0019] In some embodiments, the magnetic resonance imaging system further includes a scanning device main body and an animal bed. The scanning device main body has a scanning cavity. The animal bed is used to send the target object into the scanning cavity, and the target object fixing device is connected to the animal bed. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] This specification will be further described by way of exemplary embodiments, and these exemplary embodiments will be described in detail through the drawings. These embodiments are not restrictive. In these embodiments, the same numbers represent the same structures, where:

[0021] Figure 1 is a schematic diagram of a magnetic resonance imaging system shown in some embodiments of this specification;

[0022] Figure 2 is an exemplary flowchart of a scanning method for combined optogenetic and magnetic resonance research shown in some embodiments of this specification;

[0023] Figure 3 is a schematic diagram of a stable connection state between the coil body and the circuit board shown in some embodiments of this specification;

[0024] Figure 4 is a schematic diagram of a fixing structure between the coil body and the circuit board shown in some embodiments of this specification;

[0025] Figure 5 is an exemplary flowchart of a method for fixing a magnetic resonance coil shown in some embodiments of this specification. Detailed implementation manners

[0026] To more clearly illustrate the technical solutions of the embodiments of this specification, the following will briefly introduce the accompanying drawings required for the description of the embodiments. Obviously, the accompanying drawings in the following description are only some examples or embodiments of this specification. For those of ordinary skill in the art, without creative efforts, this specification can also be applied to other similar scenarios based on these drawings. Unless obvious from the language context or otherwise stated, the same reference numerals in the drawings represent the same structure or operation.

[0027] It should be understood that the "system", "device", "unit" and / or "module" used herein is a way to distinguish different components, elements, parts, portions or assemblies at different levels. However, if other words can achieve the same purpose, the said words can be replaced by other expressions.

[0028] As shown in this specification and the claims, unless the context clearly indicates an exceptional situation, words such as "a", "an", "one" and / or "the" do not specifically refer to the singular and may also include the plural. Generally speaking, the terms "include" and "comprise" only indicate the inclusion of the steps and elements that have been clearly identified, and these steps and elements do not constitute an exclusive list. The method or device may also include other steps or elements.

[0029] Flowcharts are used in this specification to illustrate the operations performed by the system according to the embodiments of this specification. It should be understood that the previous or subsequent operations do not necessarily need to be executed precisely in sequence. On the contrary, they can be executed in reverse order or simultaneously. At the same time, other operations can also be added to these processes, or one or several steps can be removed from these processes.

[0030] Optogenetics has a wide range of applications in neuroscience research such as exploring neural circuits, memory, and learning processes. The effects of light of a specific wavelength on neurons can often be presented by means of magnetic resonance imaging scans.

[0031] During the scanning process of some combined optogenetic and magnetic resonance studies, the coil body of the magnetic resonance coil and the circuit board can be pre-welded together. When magnetic resonance scanning is required, an optical fiber needs to be implanted and fixed in advance at a preset part of the target object, and invasive skull fixation is also required in the study of awake mice. Then, the target object is fixed to the magnetic resonance coil, resulting in the magnetic resonance coil not being able to fit closely to the target object. This method causes the distance between the magnetic resonance coil and the target object to increase due to the interference of the fixing material, inevitably causing difficulty in the contact between the target object and the magnetic resonance coil, and significantly reducing the signal-to-noise ratio of the magnetic resonance imaging scan.

[0032] Some embodiments of this specification provide a scanning component and method for combined optogenetic and magnetic resonance research, which can achieve at least the following effects: (1) Fix the magnetic resonance coil to a preset part of the target object in advance, solving the interference problem of the connection material when the magnetic resonance coil is installed at the preset part, and facilitating the installation and fixation operation of the magnetic resonance coil; (2) Can make the coil body of the magnetic resonance coil fit the target object more closely, eliminating the problem of reduced signal-to-noise ratio of the magnetic resonance scan image caused by the increased distance between the magnetic resonance coil and the target object due to the fixing material; (3) The coil body and the circuit board of the magnetic resonance coil are detachably connected by a buckle, which is convenient for installation and disassembly, simple to operate, and one circuit board can be adapted to multiple coil bodies. After the experiment, the magnetic resonance coil can be recycled, saving resources.

[0033] Figure 1 is a schematic diagram of a magnetic resonance imaging system according to some embodiments of this specification.

[0034] As Figure 1 shown, the magnetic resonance imaging system 100 includes a scanning component 110, a scanning device main body 120, and an animal bed 130.

[0035] The scanning component 110 is used to obtain magnetic resonance signals (such as magnetic resonance images, etc.) of a preset part of the target object. In some embodiments, the scanning component 110 can also be used for combined optogenetic and magnetic resonance research, and the scanning component 110 can also be referred to as a scanning component for combined optogenetic and magnetic resonance research.

[0036] In some embodiments, the scanning component 110 can include a magnetic resonance coil and a circuit board fixing device 113. In some embodiments, the magnetic resonance coil includes a coil body 111 and a circuit board 112. The coil body 111 is used to be fixed to a preset part of the target object, and the circuit board fixing device 113 is used to fix the circuit board 112.

[0037] In some embodiments, the scanning component 110 can further include a target object fixing device 114, which is used to fix the target object; the circuit board fixing device 113 is fixed on the target object fixing device 114.

[0038] In some embodiments, the magnetic resonance imaging system further includes a scanning device main body 120 and an animal bed 130.

[0039] The scanning device main body 120 has a scanning cavity 121. The animal bed 130 is used to send the target object into the scanning cavity 121, and the target object fixing device 114 is connected to the animal bed 130.

[0040] The scanning device main body 120 is used to scan a preset part of a target object. For example, the scanning component 110 fixed with the target object can be sent into the scanning cavity 121 of the scanning device main body 120 through the animal bed 130 for magnetic resonance scanning. The scanning device main body 120 can be a magnetic resonance imaging device or the like.

[0041] In some embodiments, the scanning component 110 can be connected to the animal bed 130 through the target object fixing device 114. For example, the target object fixing device 114 can include a plurality of fixing holes (or fixing rods) and be connected to the animal bed 130 through the aforementioned fixing holes.

[0042] In some embodiments, in addition to the scanning component 110, the scanning device main body 120, and the animal bed 130 described in the above embodiments, the magnetic resonance imaging system 100 can further include other various components / modules / units not shown, such as a processor, a network, a storage device, an input / output device, etc.

[0043] Some embodiments of this specification also provide an imaging system for optogenetic and magnetic resonance combined research. The imaging system for optogenetic and magnetic resonance combined research includes the magnetic resonance imaging system in any of the above embodiments, and further includes an optical fiber 140 and a light emitting device 150.

[0044] In optogenetic and magnetic resonance combined research, the light emitting device 150 can transmit a light signal with a specific wavelength through the optical fiber 140 to stimulate a preset part of the target object. In some embodiments, the processor can control the light emitting device 150 to emit a light signal with a specific wavelength and transmit it through the optical fiber 140 to the preset part of the target object. The scanning device main body 120 acquires the magnetic resonance signal of the target object under the stimulation of the light signal through a magnetic resonance coil (including a coil body 111 and a circuit board 112) and generates a corresponding magnetic resonance image. In some embodiments, the scanning device main body 120 can be connected to the circuit board 112 in a wired manner.

[0045] Figure 2 is an exemplary flowchart of a scanning method for optogenetic and magnetic resonance combined research shown in some embodiments of this specification. In some embodiments, the process 200 can be executed based on the imaging system for optogenetic and magnetic resonance combined research. As Figure 2 shown, the process 200 includes the following steps.

[0046] Step 210, fixing the coil body and the optical fiber head to a preset part of the target object.

[0047] To determine the influence of the light signal on the neurons of the target object, the optical fiber head of the optical fiber 140 needs to be implanted into the body of the target object. For example, the optical fiber head of the optical fiber 140 can be implanted into the brain of a mouse or the like.

[0048] The target object refers to the object for optogenetic research. In some embodiments, the target object can be a mouse. In other embodiments, the target object can also be other animals suitable for optogenetic research, such as rats, etc., which are not limited herein. For ease of description, the following will take the target object as a mouse as an example for illustration.

[0049] The preset part of the target object can be the brain of the mouse.

[0050] It should be noted that after the fiber optic head is implanted into the preset part of the target object, it may cause trauma to the target object. In order to obtain more accurate and effective magnetic resonance signals, it is necessary to wait for the target object to recover for a period of time before conducting the joint research of optogenetics and magnetic resonance scanning. In some embodiments of this specification, the fiber optic head of the optical fiber 140 can be pre-fixed to the preset part of the target object. For example, the fiber optic head of the optical fiber 140 can be pre-implanted into the brain of the target object and fixed with a fixing material. Among them, the fixing material refers to a non-toxic and harmless adhesive material for the target object. In some embodiments, the fixing material can be dental cement. The fixing material can be other materials, such as light-curing resin, etc., which are not limited herein.

[0051] In some embodiments, when fixing the fiber optic head of the optical fiber 140 to the preset part of the target object, the coil body 111 of the magnetic resonance coil can be fixed to the preset part of the target object at the same time. For example, the fiber optic head of the optical fiber 140 can be first implanted into the brain of the mouse, then the coil body 111 is attached to the brain of the mouse, and finally the fiber optic head and the coil body 111 are fixed to the brain of the mouse through a fixing material such as dental cement.

[0052] In some embodiments, when the coil body 111 is fixed to the preset part of the target object, the coil body 111 is attached to the preset part of the target object.

[0053] In some embodiments, when fixing the coil body 111 and the fiber optic head to the preset part of the target object, the optical fiber is inserted into the coil range of the coil body 111 and fixed to the preset part of the target object.

[0054] The coil body 111 can be used in cooperation with the circuit board 112 to obtain the magnetic resonance signal of the preset part of the target object.

[0055] The magnetic resonance signal can record the changes in brain activity of the target object after being stimulated by light.

[0056] In some embodiments, when fixing the coil body 111 to the fiber optic head and the target object, a protective film (such as a high-temperature tape) can be wound around the surface of the coil body 111 before fixing. After each magnetic resonance scan is completed, the aforementioned protective film can be torn off to prevent the coil body 111 from being contaminated by the fixing material (or the target object), facilitating the subsequent recycling of the coil body 111.

[0057] In some embodiments of the present specification, when fixing the fiber optic head, the coil body 111 is fixed to a preset part of the target object at the same time, which makes the operation more convenient and fast; at the same time, the coil body 111 fits more closely to the preset part of the target object, reducing the interference effect of the fixing material on the magnetic resonance coil and obtaining a better magnetic resonance imaging effect.

[0058] Step 220: Connect the coil body to the circuit board.

[0059] The circuit board 112 can cooperate with the coil body 111 to receive the magnetic resonance signal of the preset part of the target object. Only by way of example, the circuit board can include a ceramic circuit board, an alumina ceramic circuit board, a aluminum nitride ceramic circuit board, a printed circuit board (PCB), etc.

[0060] In some embodiments, the coil body 111 and the circuit board 112 are detachably connected, including: when the coil body 111 is fixed to the preset part of the target object, the coil body 111 and the circuit board 112 are not connected; when performing magnetic resonance scanning, the coil body 111 and the circuit board 112 are connected.

[0061] In some embodiments of the present specification, the coil body 111 and the circuit board 112 are detachably connected, which facilitates the fixing operation of the coil body 111 to the target object; in addition, one circuit board 112 can be adapted to multiple coil bodies. After the magnetic resonance scanning is completed, the coil body is convenient to recycle and clean, can be used multiple times, and saves resources.

[0062] In some embodiments, the coil body 111 and the circuit board 112 are detachably connected by a buckle.

[0063] Figure 3 It is a schematic diagram of the stable connection state between the coil body and the circuit board shown in some embodiments of the present specification. As Figure 3 shown, the coil body 111 and the circuit board 112 are stably connected by a buckle.

[0064] Figure 4 It is a schematic diagram of the fixing structure between the coil body and the circuit board shown in some embodiments of the present specification.

[0065] See Figure 3and Figure 4 The buckle connecting the coil body 111 and the circuit board 112 includes a locking device 1151 and a limiting device 1152.

[0066] The locking device 1151 and the limiting device 1152 can cooperate with each other to realize the connection between the coil body 111 and the circuit board 112. Exemplarily, when the connection position between the coil body 111 and the circuit board 112 is correct, the locking device 1151 can be locked with the limiting device 1152, and the limiting device 1152 restricts the front-back movement of the coil body 111 to realize the stable connection between the coil body 111 and the circuit board 112. When it is necessary to disconnect the coil body 111 from the circuit board 112, the locking device 1151 can be pressed to lift it. At this time, the limiting device 1152 cannot restrict the movement of the coil body 111, and the coil body 111 and the circuit board 112 can be disconnected. The above descriptions of the buckle, the locking device 1151, and the limiting device 1152 are only examples. The buckle can also be a push buckle, a sliding buckle, a twisting buckle, a flipping buckle, etc., and the corresponding locking device 1151 and limiting device 1152 can also be correspondingly modified, which are not limited herein.

[0067] In some embodiments, the magnetic resonance coil is a single-loop coil. Correspondingly, the coil body 111 is also a single-loop coil. In some embodiments, the coil body 111 of the magnetic resonance coil is a ring structure. In some embodiments, the coil body 111 is a single-loop structure. In some embodiments, the coil body 111 is circular or elliptical. In some embodiments, the single-loop structure of the coil body 111 is not in a plane but a curved surface structure, that is, the plane where the single-loop structure is located is a curved surface. In some embodiments, the plane where the single-loop structure is located is an arc surface. The curved surface structure conforms to the shape of the preset part of the target object and can fit well with the preset part of the animal, improving the magnetic resonance imaging quality.

[0068] In some embodiments of this specification, the single-loop coil has a simple structure, few channels, is easy to implement, and is less affected by other components (such as fixing materials, etc.), and can better acquire the magnetic resonance signal of the preset part.

[0069] In some embodiments, the circuit board 112 and the coil body 111 are connected through two contact points. Refer to Figure 4 , and the two contact points 116 are arranged on the side where the buckle structure of the coil body 111 is connected to the circuit board 112. After the coil body 111 and the circuit board 112 are clamped by the buckle (i.e., the locking device 1151 and the limiting device 1152), the coil body 111 is locked, and the two contact points 116 can be tightly connected to the circuit board 112 to avoid poor contact.

[0070] In some embodiments, when the target object is in an anesthetized state, a simple non-invasive fixation is required. For example, after fixedly connecting the target object to an optical fiber and a magnetic resonance coil 111, the target object is fixed by means such as adhesion or tying, and then the coil body 111 and the circuit board 112 are snap-connected and then magnetic resonance scanning is performed.

[0071] In some embodiments, in order to obtain optogenetic research data of the target object in a waking state, anesthesia cannot be performed on it. To avoid the influence of the struggling of the target object on the experimental data, the target object needs to be fixed very firmly, and this special fixing method is often invasive.

[0072] In some embodiments, the scanning assembly 110 may further include a target object fixing device 114.

[0073] The target object fixing device 114 is used to fix the target object. In some embodiments, the target object fixing device 114 may include a fixing bracket.

[0074] The fixing bracket is used to fix the target object. In some embodiments, the fixing bracket may include a dental rod and an ear rod. The teeth of the target object (such as a mouse) can be fixed on the dental rod, and its ears can be fixed through the ear rod (such as by bolts or puncture fixation), so that the fixation of the head of the target object can be achieved.

[0075] In some embodiments, fixing the target object further includes fixing the limbs of the target object. For example, the limbs of the target object can be fixed by special protective devices and jigs.

[0076] The above description of the fixation of the target object is only an exemplary illustration, and those skilled in the art can also fix the target object to the target object fixing device 114 in other ways (such as by medical glue fixation, etc.), which is not limited herein.

[0077] In some embodiments, the scanning assembly 110 may further include a circuit board fixing device 113. The circuit board fixing device 113 can be fixed on the target object fixing device 114.

[0078] In some embodiments, the circuit board 112 can be fixed to the circuit board fixing device 113. As Figure 1 shown, the circuit board 112 can be fixed to the circuit board fixing device 113 in various ways. For example, the circuit board 112 can be fixed to the circuit board fixing device 113 by means such as snap connection, adhesion, or welding.

[0079] It should be noted that in step 220, the coil body 111 and the fiber optic head have been pre-fixed to the preset part of the target object. To reduce the impact of the trauma caused to the target object when implanting the fiber optic head and obtain more accurate magnetic resonance signals, after fixing the fiber optic head and the coil body 111 to the preset part of the target object, the target object can be allowed to recover for a period of time (such as 7 days, 10 days, etc.), and then the coil body 111 can be connected to the circuit board 112 for the combined study of optogenetics and magnetic resonance.

[0080] In some embodiments, when performing the combined study of optogenetics and magnetic resonance on a conscious target object, connecting the coil body 111 to the circuit board 112 includes: first fixing the target object to the target object fixing device 114, and then connecting the coil body 111 to the circuit board 112.

[0081] Step 230, obtaining magnetic resonance signals of the preset part based on the coil body and the circuit board.

[0082] The main body 120 of the scanning device can obtain the magnetic resonance signals of the target object under the stimulation of specific optical signals through the coil body 111 and the circuit board 112, and generate corresponding magnetic resonance images. For example, the scanning component 110 fixed with the target object can be fixed to the animal bed 130 through the target object fixing device 114, and the animal bed 130 sends the scanning component 110 and the target object into the scanning cavity 121 of the main body 120 of the scanning device; at the same time, the processor controls the light emitting device 150 to transmit optical signals of a specific wavelength through the optical fiber 140 to stimulate the preset part of the target object, and the main body 120 of the scanning device obtains the magnetic resonance signals of the preset part based on the coil body 111 and the circuit board 112.

[0083] Some embodiments of this specification also provide a method for fixing a magnetic resonance coil.

[0084] Figure 5 It is an exemplary flowchart of the method for fixing a magnetic resonance coil shown in some embodiments of this specification. In some embodiments, the process 500 can be executed based on the scanning component 110 as described in any of the above embodiments. As Figure 5 shown, the process 500 includes the following steps.

[0085] Step 510, fixing the coil body to the preset part of the target object.

[0086] The coil body 111 can be fixed to the preset part of the target object based on dental cement. In some embodiments, when the coil body 111 is fixed to the preset part of the target object, the coil body 111 fits to the preset part of the target object.

[0087] In some embodiments, while the coil body 111 is fixed to a preset part of the target object, the fiber head of the optical fiber 140 can also be implanted into the aforementioned preset part and fixed by dental cement. For more descriptions on fixing the coil body 111 to the preset part of the target object, reference can be made to Figure 2 and its related descriptions.

[0088] Step 520: Connect the coil body to the circuit board.

[0089] In some embodiments, the coil body 111 can be connected to the circuit board 112 through a buckle. For more descriptions on connecting the coil body to the circuit board, reference can be made to Figures 2 to 4 its related descriptions.

[0090] In some embodiments of this specification, by first connecting the coil body to the preset part of the target object and then connecting the coil body to the circuit board, at least the following effects can be achieved: (1) The interference problem of the connection material when the magnetic resonance coil is installed at the preset part is solved, facilitating the installation and fixation operation of the magnetic resonance coil; (2) The coil body of the magnetic resonance coil can be made to fit the target object more closely, eliminating the problem that the signal-to-noise ratio of the magnetic resonance scan image decreases due to the increase in the distance between the magnetic resonance coil and the target object caused by the fixing material.

[0091] The basic concepts have been described above. Obviously, for those skilled in the art, the above detailed disclosure is only an example and does not constitute a limitation to this specification. Although not explicitly stated here, those skilled in the art may make various modifications, improvements, and corrections to this specification. Such modifications, improvements, and corrections are proposed in this specification, so such modifications, improvements, and corrections still fall within the spirit and scope of the exemplary embodiments of this specification.

[0092] At the same time, this specification uses specific terms to describe the embodiments of this specification. Such as "one embodiment", "an embodiment", and / or "some embodiments" mean a certain feature, structure, or characteristic related to at least one embodiment of this specification. Therefore, it should be emphasized and noted that "an embodiment" or "one embodiment" or "an alternative embodiment" mentioned twice or more at different positions in this specification does not necessarily refer to the same embodiment. In addition, certain features, structures, or characteristics in one or more embodiments of this specification can be appropriately combined.

[0093] In addition, unless clearly stated in the claims, the order of the processing elements and sequences, the use of numerical and alphabetical characters, or the use of other names described in this specification are not used to limit the order of the processes and methods in this specification. Although some currently useful embodiments of the invention are discussed through various examples in the above disclosure, it should be understood that such details are for illustrative purposes only. The appended claims are not limited to the disclosed embodiments. On the contrary, the claims are intended to cover all modifications and equivalent combinations that conform to the essence and scope of the embodiments of this specification. For example, although the system components described above can be implemented by hardware devices, they can also be implemented only through software solutions, such as installing the described system on existing servers or mobile devices.

[0094] Similarly, it should be noted that, in order to simplify the presentation of the disclosure in this specification and thus help the understanding of one or more embodiments of the invention, in the previous description of the embodiments of this specification, sometimes multiple features are merged into one embodiment, drawing, or description thereof. However, this method of disclosure does not mean that the features required by the subject matter of this specification are more than those mentioned in the claims. In fact, the features of the embodiments are fewer than all the features of the individual embodiments disclosed above.

[0095] In some embodiments, numbers are used to describe the components and the quantity of attributes. It should be understood that such numbers used to describe the embodiments are modified by the modifiers "about", "approximate", or "substantially" in some examples. Unless otherwise stated, "about", "approximate", or "substantially" indicate that the stated number allows a ±20% variation. Accordingly, in some embodiments, the numerical parameters used in the specification and claims are approximate values, and such approximate values may change according to the characteristics required by individual embodiments. In some embodiments, the numerical parameters should consider the specified significant digits and adopt the method of retaining the general number of digits. Although the numerical ranges and parameters used in some embodiments of this specification to confirm the breadth of their scope are approximate values, in specific embodiments, such numerical settings are as precise as possible within the feasible range.

[0096] For each patent, patent application, patent application publication, and other materials cited in this specification, such as articles, books, specifications, publications, documents, etc., their entire contents are hereby incorporated into this specification as references. Except for the application history documents that are inconsistent with or conflict with the content of this specification, and also except for the documents that limit the broadest scope of the claims of this specification (currently or subsequently appended to this specification). It should be noted that if there are inconsistencies or conflicts between the descriptions, definitions, and / or uses of terms in the supplementary materials of this specification and the content described in this specification, the descriptions, definitions, and / or uses of terms in this specification shall prevail.

[0097] Finally, it should be understood that the embodiments described in this specification are only used to illustrate the principles of the embodiments of this specification. Other variations may also fall within the scope of this specification. Therefore, by way of example and not limitation, alternative configurations of the embodiments of this specification may be regarded as consistent with the teachings of this specification. Accordingly, the embodiments of this specification are not limited to the embodiments explicitly presented and described in this specification.

Claims

1. A scanning component for combined optogenetic and magnetic resonance research, characterized in that The scanning assembly includes: a magnetic resonance coil and a circuit board fixing device; the magnetic resonance coil includes a coil body and a circuit board; The coil body is used to be fixed at a preset part of the target object; The magnetic resonance coil is used to acquire magnetic resonance signals of the preset part, and the coil body and the circuit board are detachably connected; The circuit board fixing device is used to fix the circuit board.

2. The scanning component according to claim 1, characterized in that, The detachable connection between the coil body and the circuit board includes: When the coil body is fixed at the preset part of the target object, the coil body and the circuit board are not connected; When performing magnetic resonance scanning, the coil body and the circuit board are connected.

3. The scanning component according to claim 1, characterized in that, When the coil body is fixed at the preset part of the target object, the coil body fits the preset part.

4. The scanning component according to claim 2, characterized in that, The coil body and the circuit board are detachably connected by a buckle.

5. The scanning assembly according to claim 2, characterized in that, The magnetic resonance coil is a single-loop coil, and the circuit board is connected to the coil body through two contact points.

6. The scanning assembly according to claim 1, characterized in that, The coil body is used to be fixed to the preset part of the target object by dental cement; the target object is a mouse; the preset part is the brain of the mouse.

7. The scanning component according to claim 1, wherein, The scanning assembly further includes a target object fixing device, and the target object fixing device is used to fix the target object; the circuit board fixing device is fixed on the target object fixing device.

8. A scanning method for combined optogenetic and magnetic resonance research, characterized in that, The method includes: Fixing the coil body and the optical fiber head at a preset part of the target object; Connecting the coil body to the circuit board; and Acquiring magnetic resonance signals of the preset part based on the coil body and the circuit board.

9. The method according to claim 7, wherein The fixing the coil body and the optical fiber head at a preset part of the target object includes: fixing the coil body to the preset part of the target object by dental cement; and implanting the optical fiber head into the preset part and fixing it with the dental cement; the target object is a mouse; the preset part is the brain of the mouse.

10. The method according to claim 7, wherein The fixing the coil body and the optical fiber head at a preset part of the target object includes: fitting the coil body to the preset part.

11. A fixing method for a magnetic resonance coil, characterized in that, The method is carried out by using the scanning assembly according to any one of claims 1-7, and the method includes: Fixing the coil body at a preset part of the target object; Connecting the coil body to the circuit board.

12. A magnetic resonance imaging system, characterized in that, The magnetic resonance imaging system includes: A scanning assembly, the scanning assembly includes: a magnetic resonance coil and a circuit board fixing device; the magnetic resonance coil includes a coil body and a circuit board; The coil body is used to be fixed at a preset part of the target object; The circuit board fixing device is used to fix the circuit board; The scanning assembly further includes a target object fixing device, and the target object fixing device is used to fix the target object; the circuit board fixing device is fixed on the target object fixing device.

13. The magnetic resonance imaging system according to claim 12, wherein, The magnetic resonance imaging system further includes a scanning device main body and an animal bed, the scanning device main body has a scanning cavity, the animal bed is used to send the target object into the scanning cavity, and the target object fixing device is connected to the animal bed.

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