Balloon medicine coating device and method

Abstract

The invention belongs to the technical field of medicine, particularly relates to a balloon medicine coating device and method, and provides the following scheme that the balloon medicine coating device comprises a base, an electrostatic spraying mechanism is arranged on one side of the top of the base, the other side of the top of the base is rotationally connected with a rotating disc through a damping bearing, and an adjusting mechanism is arranged on the top of the rotating disc; a supporting mechanism is arranged on one side of the adjusting mechanism, a coating mechanism is arranged in the supporting mechanism, the coating mechanism comprises a balloon dilatation pressure pump, a connecting pipe and a balloon catheter, a pressure gauge is arranged on one side of the balloon dilatation pressure pump, and a piston rod is slidably connected to the inner wall of the balloon dilatation pressure pump; and a push handle is arranged at the top of the piston rod. According to the device and the method, the situation that medicine coating of a patient is affected by uneven distribution of the medicine on the balloon due to falling of the medicine in the coating process is prevented, it can be ensured that the medicine is evenly distributed on the surface of the balloon through electrostatic spraying, and therefore the medicine can be stably attached to the balloon.

Description

Technical Field

[0001] The present invention relates to the field of medicine, and particularly to a balloon drug coating device and method. Background Art

[0002] The drug-coated balloon is essentially a medical device, and its core function is to achieve local drug release through balloon dilation. The drug only adheres to the surface or inside of the balloon and plays an auxiliary therapeutic role. The physical properties of the balloon (such as flexibility, pushability, passability, etc.) are crucial for the treatment effect. Stenosis at the origin of the vertebral artery is an important cause of posterior circulation ischemia, and the clinical efficacy of drug-coated balloons in treating stenosis at the origin of the vertebral artery has been somewhat verified.

[0003] After retrieval, a Chinese patent application with the publication number of CN113893446B discloses a drug-coated balloon catheter and system, which is applied to a stenotic body cavity. The balloon catheter includes a catheter body, an outer balloon, and an inner balloon; the outer balloon is fitted at the distal end of the catheter body; the inner balloon is fitted in the outer balloon with a clearance; at least one convex part facing the outer balloon is constructed on the surface of the inner balloon catheter; an outer fluid channel communicating with the outer balloon and an inner fluid channel communicating with the inner balloon are constructed at the distal end of the catheter body; a liquid nozzle and an outer pressure control nozzle respectively communicating with the outer fluid channel, and an inner pressure control nozzle communicating with the inner fluid pipeline are constructed at the proximal end of the catheter body; a drug coating is formed on the surface of the outer balloon.

[0004] Compared with drug-eluting balloons, drug-coated balloons are more mature in current technologies and applications. The drug release mechanism of drug-coated balloons is relatively simple. The drug directly adheres to the surface of the balloon and is released to the lesion site during dilation. During the coating process, contrast agent is inhaled into the interior of the balloon dilation pressure pump, and the contrast agent is transported into the interior of the balloon catheter by squeezing the balloon dilation pressure pump to fill and dilate the balloon. At this time, the drug is adhered to the surface of the dilated balloon. However, the drug is prone to falling off when adhering to the balloon, resulting in uneven distribution of the drug adhered to the balloon, and further affecting the drug application to the lesion site of the patient. Summary of the Invention

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A balloon drug coating device, comprising a base. On one side of the top of the base, an electrostatic spraying mechanism is provided. On the other side of the top of the base, a turntable is rotatably connected through a damping bearing, and an adjusting mechanism is provided on the top of the turntable. On one side of the adjusting mechanism, a supporting mechanism is provided, and a coating mechanism is arranged inside the supporting mechanism. The coating mechanism includes a balloon expansion pressure pump, a connecting pipe and a balloon catheter. On one side of the balloon expansion pressure pump, a pressure gauge is provided. A piston rod is slidably connected to the inner wall of the balloon expansion pressure pump, and a push handle is provided at the top of the piston rod. The bottom of the balloon expansion pressure pump is fixedly connected to the connecting pipe. The connecting pipe is made of a flexible hose material. A pipe joint is provided at the bottom of the connecting pipe, and the inner wall of the pipe joint is inserted with the balloon catheter. A plurality of through holes are opened on one side of the outer wall of the balloon catheter. A balloon is arranged inside the balloon catheter. A plurality of micropores are provided on the outer wall of the balloon, and a wrinkle is provided on one side of the micropores.

[0007] Preferably, the adjusting mechanism includes an adjusting frame, a screw rod, an adjusting block and a rotating wheel. The bottom of the adjusting frame is bolted to the top of the turntable. The adjusting block is slidably connected inside the adjusting frame. The two ends of the screw rod are rotatably connected to the opposite sides of the adjusting block through bearings. A threaded hole is opened through the top of the adjusting block, and the threaded hole is threadedly connected to the screw rod. Positioning ports are opened through the opposite sides of the adjusting frame. A positioning block is slidably connected to the inner wall of the positioning port, and the positioning block is fixedly connected to the adjusting block. The rotating wheel is bolted to the top of the screw rod.

[0008] Preferably, the supporting mechanism is composed of a support plate, a support seat and a fixed seat. One side of the support plate is fixedly connected to the adjusting block, and the other side of the support plate is welded to the support seat. A plurality of legs are welded between the top of the support seat and the bottom of the fixed seat. An insertion port is opened through the top of the support seat, and a limiting port is opened through the top of the fixed seat. The position of the limiting port corresponds to that of the insertion port. A threaded port is opened through one side of the limiting port, and a fastening bolt is threadedly connected to the threaded port.

[0009] Preferably, the electrostatic spraying mechanism includes an electrostatic generator, a cylinder body and a conveying mechanism. The bottom of the electrostatic generator is bolted to the top of the base. The bottom of the cylinder body is fixedly connected to the electrostatic generator. A controller is bolted to one side of the electrostatic generator. A partition plate is bolted to the inner wall of the cylinder body. A cavity is opened inside the partition plate. A plurality of spray ports are opened through the top of the cavity. The conveying mechanism is fixed to the bottom of the partition plate.

[0010] Preferably, the conveying mechanism consists of a first conveying pump, a liquid inlet pipe, a liquid discharge pipe and an atomizing nozzle, and the bottom of the first conveying pump is fixedly connected to the bottom of the cylinder, one end of the first conveying pump is connected to the liquid inlet pipe through a flange, and the other end of the first conveying pump is connected to the liquid discharge pipe through a flange. A fixed port is provided at the bottom of the cavity, and the fixed port is fixedly connected to one end of the atomizing nozzle, and the other end of the atomizing nozzle is connected to the liquid discharge pipe through a flange.

[0011] Preferably, a shaking mechanism is provided inside the cylinder, and the shaking mechanism cooperates with the electrostatic spraying mechanism, and the shaking mechanism is located above the electrostatic spraying mechanism.

[0012] Preferably, the shaking mechanism consists of an annular tube and two second delivery pumps, and the outer wall of the annular tube is fixedly connected to the inner wall of the cylinder, the second delivery pump is fixedly connected to the outer wall of the cylinder, a discharge pipe is arranged between the top of the second delivery pump and the annular tube, an inlet pipe is arranged between the bottom of the second delivery pump and the cavity, a plurality of spray holes are opened on the inner wall of the annular tube, and a plurality of spray pipes are fixed to the inner wall of the spray holes.

[0013] Preferably, the sizes of the plurality of nozzles are different.

[0014] A method for coating a balloon with medicine, comprising the following specific steps:

[0015] S1: When spraying the drug on the surface of the balloon, the drug is placed inside the electrostatic spraying mechanism, and after the drug is placed, the electrostatic generator is started by the controller;

[0016] S2: After filling, the contrast agent is sucked into the balloon dilatation pressure pump. After the suction is completed, the balloon catheter is connected to the inside of the pipe joint. After the connection is completed, the balloon dilatation pressure pump is fixed on the support mechanism. At this time, the turntable is turned to make the balloon catheter located directly above the electrostatic spraying mechanism, and the balloon dilatation pressure pump is squeezed to transport the contrast agent to the inside of the balloon catheter through the connecting tube so that the balloon is in a filled and expanded state;

[0017] S3: Start the adjustment mechanism, which will drive the balloon catheter to move downward, so that the balloon is located inside the electrostatic spraying mechanism, and the atomized drug is transported to the inside of the cavity through the delivery mechanism and the atomizing nozzle, and sprayed out through the nozzle, so that the drug adheres to the surface of the balloon through static electricity. When the balloon bulges under the filling of the contrast agent, the surface area of ​​the balloon will increase, the folds will open, and the drug will be sprayed on the surface of the balloon and the folds. During this period, the second delivery pump will transport the atomized drug to the inside of the ring tube through the inlet tube and the discharge tube, and spray it out through the nozzle, so that the drug adheres to the surface of the balloon;

[0018] S4: After the spraying is completed, the contrast agent is aspirated through the balloon dilation pressure pump to relieve the pressure inside the balloon. At this time, the balloon will contract, and the folds will retract inside the balloon;

[0019] S5: After the drug spraying is completed, the coating mechanism is removed from the support mechanism, the balloon is separated from the balloon dilation pressure pump, and the balloon is carried with the balloon catheter and transported to the lesion site of the vascular stenosis through the guiding catheter. After intraoperative angiography confirms that the balloon is in good position, the balloon dilation pressure pump is connected, and the balloon is dilated and filled. The folds will fully expand accordingly, and the balloon is kept in the expanded state for several minutes to release and adhere the drug pre-uniformly coated on the balloon surface to the intima of the diseased segment of the blood vessel to play a therapeutic role. The drugs on the surface of the folds and the balloon surface will adhere to the inner wall of the blood vessel;

[0020] S6: After the treatment purpose is completed, the pressure of the balloon dilation pressure pump is released, the balloon is withdrawn into the balloon catheter, and both are withdrawn from the body to complete the surgical operation.

[0021] The beneficial effects of the present invention are:

[0022] 1. The present invention uses the electrostatic spraying mechanism and coating mechanism to suck the contrast agent into the balloon expansion pressure pump during the balloon drug coating. After the suction is completed, the balloon catheter is connected to the inside of the pipe joint. After the connection is completed, the balloon expansion pressure pump is fixed on the supporting mechanism. At this time, the turntable is rotated to make the balloon catheter located directly above the electrostatic spraying mechanism, and the balloon expansion pressure pump is squeezed to transport the contrast agent to the inside of the balloon catheter through the connecting tube so that the balloon is in a filled and expanded state. At this time, the regulating mechanism is started, and the regulating mechanism will drive the balloon catheter to move downward, so that the balloon is located inside the electrostatic spraying mechanism, so that the drug is sprayed on the surface of the balloon through the electrostatic spraying mechanism. During this period, when the balloon bulges under the action of the contrast agent, the surface area of ​​the balloon will increase, and the folds will be stretched, and the drug will be sprayed on the surface of the balloon and the folds. After the spraying is completed, the contrast agent is extracted by the balloon expansion pressure pump. At this time, the balloon will retract, and the folds will shrink inside the balloon, and the drug can be sprayed through the folds. The coating mechanism is hidden, and the coating mechanism is taken out from the supporting mechanism, and the balloon catheter is separated from the balloon expansion pressure pump. The balloon is carried by the balloon catheter and delivered to the lesion site of the stenosis of the blood vessel through the guide catheter. After the intraoperative angiography confirms that the balloon is in place, the balloon expansion pressure pump is connected to expand and fill the balloon. The balloon wrinkles will be fully expanded, and the balloon is kept in an expanded state for several minutes, so that the drug pre-uniformly coated on the balloon surface is released and adheres to the vascular intima of the lesion segment to play a therapeutic role. The drug on the wrinkled surface and the balloon surface will adhere to the inner wall of the blood vessel. After the drug coating is completed, the contrast agent is extracted by the balloon expansion pressure pump, and the balloon will shrink. At this time, the balloon catheter is taken out to complete the coating of the drug. The effect of the wrinkles can adhere to and hide the drug, preventing the drug from falling off during the coating process, thereby causing uneven distribution of the drug on the balloon, and then affecting the patient's drug coating. Through electrostatic spraying, it can ensure that the drug is evenly distributed on the surface of the balloon, so that the drug can stably adhere to the balloon.

[0023] 2. The present invention provides an electrostatic spraying mechanism and a shaking mechanism. When spraying the drug on the surface of the balloon, the drug is placed in the electrostatic spraying mechanism, the atomized drug is transported to the inside of the cavity by the conveying mechanism and the atomizing nozzle, and sprayed out through the nozzle, so that the drug adheres to the surface of the balloon through static electricity. During this period, the second conveying pump conveys the atomized drug to the inside of the ring tube through the inlet pipe and the outlet pipe, and sprays it out through the nozzle, so that the drug adheres to the surface of the balloon. Since the sizes of the multiple nozzles are different, the forces acting on the balloon surface by the drug sprayed by the nozzle are different. Therefore, the balloon will shake under the action of the multiple nozzles, so as to facilitate the uniform coating of the drug on the surface of the balloon. At the same time, the drug that is not firmly adhered can be removed by shaking, so as to prevent the drug from falling off the balloon due to weak adhesion and causing uneven distribution of the drug on the balloon. Brief Description of the Drawings

[0024] Figure 1 FIG. is a schematic structural diagram of a balloon drug coating device proposed by the present invention;

[0025] Figure 2 FIG. is a schematic structural diagram of an adjustment mechanism and a coating mechanism of a balloon drug coating device proposed by the present invention;

[0026] Figure 3 FIG. is a schematic structural diagram of a coating mechanism of a balloon drug coating device proposed by the present invention;

[0027] Figure 4 FIG. is a schematic cross-sectional structure diagram of a balloon catheter of a balloon drug coating device proposed by the present invention;

[0028] Figure 5 FIG. is a schematic structural diagram of an electrostatic spraying mechanism of a balloon drug coating device proposed by the present invention;

[0029] Figure 6 FIG. is a schematic cross-sectional structure diagram of an electrostatic spraying mechanism of a balloon drug coating device proposed by the present invention;

[0030] Figure 7 FIG. is a schematic structural diagram of a shaking mechanism of a balloon drug coating device proposed by the present invention.

[0031] In the drawings: 1, base; 2, electrostatic spraying mechanism; 3, adjustment mechanism; 4, support plate; 5, coating mechanism; 6, support seat; 7, connecting pipe; 8, pipe joint; 9, balloon catheter; 10, turntable; 11, adjustment frame; 12, screw; 13, adjustment block; 14, runner; 15, fixed seat; 16, fastening bolt; 17, positioning port; 18, balloon expansion pressure pump; 19, piston rod; 20, push handle; 21, pressure gauge; 23, balloon; 24, through hole; 25, micropore; 26, fold; 27, electrostatic generator; 28, controller; 29, cylinder; 30, shaking mechanism; 31, partition board; 32, cavity; 33, nozzle; 34, conveying mechanism; 35, first conveying pump; 36, liquid inlet pipe; 37, liquid discharge pipe; 38, atomizing nozzle; 39, second conveying pump; 40, inlet pipe; 41, discharge pipe; 42, annular pipe; 43, spray pipe. Detailed Embodiments

[0032] Example 1, refer to Figures 1-7, a balloon drug coating device, comprising a base 1, an electrostatic spraying mechanism 2 is arranged on one side of the top of the base 1, a turntable 10 is rotatably connected to the other side of the top of the base 1 through a damping bearing, and an adjusting mechanism 3 is arranged on the top of the turntable 10. A support mechanism is arranged on one side of the adjusting mechanism 3, and a coating mechanism 5 is arranged inside the support mechanism. The coating mechanism 5 includes a balloon expansion pressure pump 18, a connecting pipe 7 and a balloon catheter 9. A pressure gauge 21 is arranged on one side of the balloon expansion pressure pump 18. A piston rod 19 is slidably connected to the inner wall of the balloon expansion pressure pump 18, and a push handle 20 is arranged on the top of the piston rod 19. The bottom of the balloon expansion pressure pump 18 is fixedly connected to the connecting pipe 7. The connecting pipe 7 is made of a flexible hose material. A pipe joint 8 is arranged at the bottom of the connecting pipe 7, and the inner wall of the pipe joint 8 is inserted with the balloon catheter 9. A plurality of through holes 24 are formed on one side of the outer wall of the balloon catheter 9. There is a balloon 23 inside the balloon catheter 9. A plurality of micropores 25 are arranged on the outer wall of the balloon 23, and a fold 26 is arranged on one side of the micropore 25, which can adhere to and hide the drug, preventing the drug from falling off during the coating process, resulting in uneven drug distribution on the balloon 23, and further affecting the drug coating of the patient. Through electrostatic spraying, it can ensure that the drug is evenly distributed on the surface of the balloon 23, so that the drug can stably adhere to the balloon 23.

[0033] On the above basis, the adjusting mechanism 3 includes an adjusting frame 11, a screw rod 12, an adjusting block 13 and a rotating wheel 14. The bottom of the adjusting frame 11 is bolted to the top of the turntable 10. The adjusting block 13 is slidably connected inside the adjusting frame 11. Both ends of the screw rod 12 are rotatably connected to the opposite sides of the adjusting block 13 through bearings. A threaded hole is formed through the top of the adjusting block 13, and the threaded hole is threadedly connected to the screw rod 12. Positioning ports 17 are formed through both opposite sides of the adjusting frame 11. A positioning block is slidably connected to the inner wall of the positioning port 17, and the positioning block is fixedly connected to the adjusting block 13. The rotating wheel 14 is bolted to the top of the screw rod 12.

[0034] On the above basis, the support mechanism is composed of a support plate 4, a support seat 6 and a fixed seat 15. One side of the support plate 4 is fixedly connected to the adjusting block 13, and the other side of the support plate 4 is welded to the support seat 6. A plurality of legs are welded between the top of the support seat 6 and the bottom of the fixed seat 15. An insertion port is formed through the top of the support seat 6. A limiting port is formed through the top of the fixed seat 15. The position of the limiting port corresponds to that of the insertion port. A threaded port is formed through one side of the limiting port, and a fastening bolt 16 is threadedly connected to the threaded port.

[0035] On the basis described above, the electrostatic spraying mechanism 2 includes an electrostatic generator 27, a cylinder body 29 and a conveying mechanism 34. The bottom of the electrostatic generator 27 is bolted to the top of the base 1, and the bottom of the cylinder body 29 is fixedly connected to the electrostatic generator 27. A controller 28 is bolted to one side of the electrostatic generator 27. A partition plate 31 is bolted to the inner wall of the cylinder body 29. A cavity 32 is formed inside the partition plate 31. A plurality of spray nozzles 33 are formed through the top of the cavity 32. The conveying mechanism 34 is fixed to the bottom of the partition plate 31.

[0036] On the basis described above, the conveying mechanism 34 is composed of a first delivery pump 35, a liquid inlet pipe 36, a liquid discharge pipe 37 and an atomizing nozzle 38. The bottom of the first delivery pump 35 is fixedly connected to the bottom of the cylinder body 29. One end of the first delivery pump 35 is flange-connected to the liquid inlet pipe 36. The other end of the first delivery pump 35 is flange-connected to the liquid discharge pipe 37. A fixing port is formed at the bottom of the cavity 32, and the fixing port is fixedly connected to one end of the atomizing nozzle 38. The other end of the atomizing nozzle 38 is flange-connected to the liquid discharge pipe 37.

[0037] Example 2, referring to Figures 1-7 , a balloon drug coating device. Compared with Example 1, on the basis of Example 1, a shaking mechanism 30 is arranged inside the cylinder body 29, and the shaking mechanism 30 is in cooperation with the electrostatic spraying mechanism 2. The shaking mechanism 30 is located above the electrostatic spraying mechanism 2.

[0038] On the basis described above, the shaking mechanism 30 is composed of an annular pipe 42 and two second delivery pumps 39. The outer wall of the annular pipe 42 is fixedly connected to the inner wall of the cylinder body 29. The second delivery pumps 39 are fixedly connected to the outer wall of the cylinder body 29. A discharge pipe 41 is arranged between the top of the second delivery pump 39 and the annular pipe 42. An inlet pipe 40 is arranged between the bottom of the second delivery pump 39 and the cavity 32. A plurality of spray holes are formed in the inner wall of the annular pipe 42, and a plurality of spray pipes 43 are fixed to the inner walls of the spray holes. The sizes of the plurality of spray pipes 43 are different.

[0039] A balloon drug coating method, the specific steps are as follows:

[0040] S1: When spraying drugs on the surface of the balloon 23, load the drugs into the electrostatic spraying mechanism 2. After the loading is completed, start the electrostatic generator 27 through the controller 28;

[0041] S2: After the filling is completed, the contrast agent is sucked into the balloon expansion pressure pump 18. After the suction is completed, the balloon catheter 9 is connected to the inside of the pipe joint 8. After the connection is completed, the balloon expansion pressure pump 18 is fixed on the support mechanism. At this time, the turntable 10 is rotated to make the balloon catheter 9 located directly above the electrostatic spraying mechanism 2, and the balloon expansion pressure pump 18 is squeezed to transport the contrast agent to the inside of the balloon catheter 9 through the connecting tube 7 so that the balloon 23 is in a filled and expanded state;

[0042] S3: Start the adjustment mechanism 3, which will drive the balloon catheter 9 to move downward, so that the balloon 23 is located inside the electrostatic spraying mechanism 2, and the atomized drug is transported to the inside of the cavity 32 through the conveying mechanism 34 and the atomizing nozzle 38, and sprayed out through the nozzle 33, so that the drug adheres to the surface of the balloon 23 through static electricity. When the balloon 23 bulges under the filling of the contrast agent, the surface area of ​​the balloon 23 will increase, the folds 26 will open, and the drug will be sprayed on the surface of the balloon 23 and the folds 26. During this period, the second delivery pump 39 will transport the atomized drug to the inside of the ring tube 42 through the inlet tube 40 and the discharge tube 41, and spray it out through the nozzle 43, so that the drug adheres to the surface of the balloon 23;

[0043] S4: After the spraying is completed, the contrast agent is withdrawn by the balloon expansion pressure pump 28 to relieve the pressure in the balloon 23. At this time, the balloon 23 will shrink, and the folds 26 will shrink inside the balloon 23;

[0044] S5: After the drug spraying is completed, the coating mechanism 5 is taken out from the supporting mechanism, the balloon 23 is separated from the balloon expansion pressure pump 18, and the balloon 23 is carried by the balloon catheter 9 and transported to the lesion site of the stenosis of the blood vessel through the guide catheter. After the intraoperative angiography confirms that the balloon 23 is in place, the balloon expansion pressure pump 18 is connected to expand and fill the balloon 23, and the wrinkles will be fully expanded. The balloon 23 is kept in the expanded state for several minutes, so that the drug pre-uniformly coated on the surface of the balloon 23 is released and adhered to the endothelium of the lesion segment to play a therapeutic role, and the drugs on the surface of the wrinkles 26 and the surface of the balloon 23 will adhere to the inner wall of the blood vessel;

[0045] S6: After the treatment purpose is achieved, the pressure of the balloon expansion pressure pump 18 is released, and the balloon 23 is withdrawn back into the balloon catheter 9 and then withdrawn from the body to complete the surgical operation.

[0046] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A balloon drug coating device, comprising a base (1), characterized in that: An electrostatic spraying mechanism (2) is arranged on one side of the top of the base (1), a turntable (10) is rotatably connected to the other side of the top of the base (1) via a damping bearing, and an adjusting mechanism (3) is arranged on the top of the turntable (10), a supporting mechanism is arranged on one side of the adjusting mechanism (3), and a coating mechanism (5) is arranged inside the supporting mechanism, the coating mechanism (5) comprises a balloon expansion pressure pump (18), a connecting pipe (7) and a balloon catheter (9), and a pressure gauge (21) is arranged on one side of the balloon expansion pressure pump (18), and a movable spring (21) is slidably connected to the inner wall of the balloon expansion pressure pump (18). The piston rod (19) is provided with a push handle (20) at the top of the piston rod (19); the bottom of the balloon expansion pressure pump (18) is fixedly connected to the connecting tube (7); the connecting tube (7) is made of a hose material; a pipe joint (8) is provided at the bottom of the connecting tube (7); and the inner wall of the pipe joint (8) is plugged into the balloon catheter (9); a plurality of through holes (24) are provided on one side of the outer wall of the balloon catheter (9); a balloon (23) is provided in the balloon catheter (9); a plurality of micropores (25) are provided on the outer wall of the balloon (23); and a fold (26) is provided on one side of the micropore (25).

2. A balloon drug coating device according to claim 1, characterized in that: The adjusting mechanism (3) comprises an adjusting frame (11), a screw rod (12), an adjusting block (13) and a rotating wheel (14), wherein the bottom of the adjusting frame (11) is connected to the top of the rotating disk (10) by bolts, the adjusting block (13) is slidably connected inside the adjusting frame (11), two ends of the screw rod (12) and two opposite sides of the adjusting block (13) are rotatably connected by bearings, a threaded hole is formed through the top of the adjusting block (13), the threaded hole is threadedly connected to the screw rod (12), positioning openings (17) are formed through the opposite sides of the adjusting frame (11), the inner wall of the positioning opening (17) is slidably connected to the positioning block, the positioning block is fixedly connected to the adjusting block (13), and the rotating wheel (14) is connected to the top of the screw rod (12) by bolts.

3. A balloon drug coating device according to claim 2, characterized in that: The support mechanism is composed of a support plate (4), a support seat (6) and a fixed seat (15), and one side of the support plate (4) is fixedly connected to the adjustment block (13), and the other side of the support plate (4) is welded to the support seat (6). A plurality of legs are welded between the top of the support seat (6) and the bottom of the fixed seat (15). A socket is provided through the top of the support seat (6), and a limiting opening is provided through the top of the fixed seat (15). The position of the limiting opening corresponds to that of the socket. A threaded opening is provided through one side of the limiting opening, and a fastening bolt (16) is threadedly connected to the threaded opening.

4. A balloon drug coating device according to claim 1, characterized in that: The electrostatic spraying mechanism (2) comprises an electrostatic generator (27), a cylinder (29) and a conveying mechanism (34), wherein the bottom of the electrostatic generator (27) is connected to the top of the base (1) by bolts, the bottom of the cylinder (29) is fixedly connected to the electrostatic generator (27), one side of the electrostatic generator (27) is connected to a controller (28) by bolts, the inner wall of the cylinder (29) is connected to a partition (31) by bolts, a cavity (32) is provided inside the partition (31), a plurality of nozzles (33) are provided through the top of the cavity (32), and the conveying mechanism (34) is fixed to the bottom of the partition (31).

5. A balloon drug coating device according to claim 4, characterized in that: The delivery mechanism (34) is composed of a first delivery pump (35), a liquid inlet pipe (36), a liquid discharge pipe (37) and an atomizing nozzle (38), wherein the bottom of the first delivery pump (35) is fixedly connected to the bottom of the cylinder (29), one end of the first delivery pump (35) is connected to the liquid inlet pipe (36) via a flange, the other end of the first delivery pump (35) is connected to the liquid discharge pipe (37) via a flange, a fixed opening is provided at the bottom of the cavity (32), the fixed opening is fixedly connected to one end of the atomizing nozzle (38), and the other end of the atomizing nozzle (38) is connected to the liquid discharge pipe (37) via a flange.

6. A balloon drug coating device according to claim 4, characterized in that: A shaking mechanism (30) is arranged inside the cylinder (29), and the shaking mechanism (30) cooperates with the electrostatic spraying mechanism (2), and the shaking mechanism (30) is located above the electrostatic spraying mechanism (2).

7. A balloon drug coating device according to claim 6, characterized in that: The shaking mechanism (30) is composed of an annular tube (42) and two second delivery pumps (39), wherein the outer wall of the annular tube (42) is fixedly connected to the inner wall of the cylinder (29), the second delivery pump (39) is fixedly connected to the outer wall of the cylinder (29), a discharge pipe (41) is arranged between the top of the second delivery pump (39) and the annular tube (42), an inlet pipe (40) is arranged between the bottom of the second delivery pump (39) and the cavity (32), a plurality of spray holes are opened on the inner wall of the annular tube (42), and a plurality of spray pipes (43) are fixed to the inner wall of the spray holes.

8. A balloon drug coating device according to claim 7, characterized in that: The sizes of the plurality of nozzles (43) are different.

9. A method for coating a balloon with a drug, characterized in that: According to any one of claims 1 to 8, the balloon drug coating device comprises the following specific steps: S1: When spraying the drug on the surface of the balloon (23), the drug is placed inside the electrostatic spraying mechanism (2), and after the drug is placed, the electrostatic generator (27) is started by the controller (28); S2: After the filling is completed, the contrast agent is sucked into the interior of the balloon expansion pressure pump (18). After the suction is completed, the balloon catheter (9) is connected to the interior of the pipe joint (8). After the connection is completed, the balloon expansion pressure pump (18) is fixed on the support mechanism. At this time, the turntable (10) is rotated to make the balloon catheter (9) located directly above the electrostatic spraying mechanism (2), and the balloon expansion pressure pump (18) is squeezed to transport the contrast agent to the interior of the balloon catheter (9) through the connecting tube (7) so that the balloon is in a filled and expanded state; S3: Start the adjustment mechanism (3), which will drive the balloon catheter (9) to move downward, so that the balloon (23) is located inside the electrostatic spraying mechanism (2), and the atomized drug is transported to the inside of the cavity (32) through the conveying mechanism (34) and the atomizing nozzle (38), and sprayed out through the nozzle (33), so that the drug adheres to the surface of the balloon (23) through static electricity. When the balloon (23) swells due to the filling of the contrast agent, the surface area of ​​the balloon (23) will increase, the folds (26) will open, and the drug will be sprayed on the surface of the balloon (23) and the folds (26). During this period, the second delivery pump (39) will transport the atomized drug to the inside of the ring tube (42) through the inlet tube (40) and the outlet tube (41), and spray it out through the nozzle (43), so that the drug adheres to the surface of the balloon (23); S4: After the spraying is completed, the contrast agent is withdrawn through the balloon expansion pressure pump (28) to relieve the pressure in the balloon (23). At this time, the balloon (23) will shrink, and the folds (26) will retract inside the balloon (23); S5: After the drug spraying is completed, the coating mechanism (5) is removed from the supporting mechanism, the balloon (23) is separated from the balloon expansion pressure pump (18), and the balloon catheter (9) is used to carry the balloon (23), and the balloon (23) is transported to the lesion site of the stenosis of the blood vessel through the guide catheter. After the intraoperative angiography confirms that the balloon (23) is in place, the balloon expansion pressure pump (18) is connected to expand and fill the balloon (23), and the wrinkles will be fully expanded. The balloon (23) is kept in an expanded state for several minutes, so that the drug pre-uniformly coated on the surface of the balloon (23) is released and adhered to the endothelium of the lesion segment, exerting a therapeutic effect, and the drug on the surface of the wrinkles (26) and the surface of the balloon (23) will adhere to the inner wall of the blood vessel; S6: After the treatment objective is achieved, the pressure of the balloon dilation pressure pump (18) is released, and the balloon (23) is withdrawn back into the balloon catheter (9) and removed from the body together, thus completing the surgical operation.

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