Bipolar nanosecond pulse synchronous output circuit and ablation equipment

Abstract

The invention relates to the technical field of medical equipment, and particularly discloses a bipolar nanosecond pulse synchronous output circuit and ablation equipment, and the bipolar nanosecond pulse synchronous output circuit comprises a positive pulse output circuit and a negative pulse output circuit, the positive pulse output circuit comprises a positive pulse charging unit, a positive pulse output control unit, a positive pulse transmission unit and a positive pulse output electrode wire which are electrically connected in sequence; the negative pulse output circuit comprises a negative pulse charging unit, a negative pulse output control unit, a negative pulse transmission unit and a negative pulse output electrode wire which are electrically connected in sequence; the positive pulse transmission unit at least comprises a forward multiplication transmission unit which is used for performing forward voltage multiplication or forward current multiplication on the forward output pulse signal; the negative pulse transmission unit at least comprises a negative multiplication transmission unit which is used for carrying out negative voltage multiplication or negative current multiplication on the negative output pulse signal. The bipolar nanosecond pulse synchronous output circuit provided by the invention can improve the instant pulse energy of nanosecond pulse tumor ablation equipment.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a bipolar nanosecond pulse synchronous output circuit and an ablation device. Background Art

[0002] The existing high-voltage short-pulse technology is increasingly used in the medical field, especially in the fields of tumor ablation, plasma sterilization, and rehabilitation. Pulsed field ablation (PFA) is an emerging technology. It completely solves the difficulties of traditional tumor ablation (microwave, radio frequency, ultrasound or laser heating or cryoablation therapy), such as non-selective ablation, obvious transition zone at the edge of the tumor, and susceptibility to heat sink effect. Therefore, pulsed field ablation (PFA) is expected to become a mainstream product in the field of tumor and cardiac ablation in the future.

[0003] At present, pulsed field ablation (PFA) has developed into the second generation of microsecond pulse ablation and the third generation of nanosecond pulse ablation. Among them, nanosecond pulse ablation has more advantages, but it is more difficult to achieve. Nanosecond pulse tumor ablation equipment needs to generate a high electric field strength greater than 10KV / cm, a nanosecond pulse width and an extremely high instantaneous pulse current (greater than 300A). In conventional nanosecond pulse implementation technology, the bandwidth of the high-frequency pulse transformer is limited by the core material and the capacitance and inductance between the windings. It is generally difficult to achieve high voltage and nanosecond pulse width, and the instantaneous pulse current is also small; the use of avalanche transistors can achieve nanosecond pulse output, but the control circuit is complex and the output instantaneous power is low; the Marx generator uses multi-stage capacitors that are charged in parallel and then discharged in series. Even if it can achieve nanosecond-level high-voltage pulses, it has technical problems such as large size, low repetition frequency, and difficult synchronous triggering control.

[0004] Therefore, how to improve the instantaneous pulse energy of nanosecond pulse tumor ablation equipment to achieve bipolar nanosecond pulse synchronous output has become a technical problem that needs to be solved urgently by those skilled in the art. Summary of the invention

[0005] The present invention provides a bipolar nanosecond pulse synchronous output circuit and ablation equipment, which solve the problem in the related art that the synchronous output of nanosecond bipolar high-voltage pulses cannot be achieved.

[0006] As a first aspect of the present invention, there is provided a bipolar nanosecond pulse synchronous output circuit, which includes: a positive pulse output circuit and a negative pulse output circuit, wherein the positive pulse output circuit and the negative pulse output circuit are electrically connected;

[0007] The positive pulse output circuit comprises a positive pulse charging unit, a positive pulse output control unit, a positive pulse transmission unit and a positive pulse output electrode line which are electrically connected in sequence;

[0008] The negative pulse output circuit includes a negative pulse charging unit, a negative pulse output control unit, a negative pulse transmission unit, and a negative pulse output electrode wire that are electrically connected in sequence;

[0009] The positive pulse charging unit is electrically connected to the negative pulse charging unit, and the positive pulse transmission unit is electrically connected to the negative pulse transmission unit;

[0010] The positive pulse charging unit is used for forward charging to a preset positive threshold, and the negative pulse charging unit is used for negative charging to a preset negative threshold, and the absolute values of the preset positive threshold and the preset negative threshold are the same;

[0011] The positive pulse output control unit is used for generating a forward output pulse signal when the positive pulse charging unit charges to the preset positive threshold, and the negative pulse output control unit is used for generating a negative-phase output pulse signal when the negative pulse charging unit charges to the preset negative threshold;

[0012] The positive pulse transmission unit at least includes a forward multiplication transmission unit for multiplying the forward output pulse signal in terms of forward voltage or forward current; the negative pulse transmission unit at least includes a negative multiplication transmission unit for multiplying the negative output pulse signal in terms of negative voltage or negative current; the multiplication amplitude of the forward output pulse signal is the same as that of the negative output pulse signal;

[0013] The positive pulse output electrode wire and the negative pulse output electrode wire are used for synchronously outputting their respective multiplied output pulse signals to the target object.

[0014] Further, the forward multiplication transmission unit includes: a first forward transmission cable and a second forward transmission cable. One end of the first forward transmission cable and one end of the second forward transmission cable are connected in parallel as the input end of the forward multiplication transmission unit, and the other end of the first forward transmission cable and the other end of the second forward transmission cable are connected in series as the output end of the forward multiplication transmission unit;

[0015] The first forward transmission cable and the second forward transmission cable can increase the forward transmission impedance by connecting their input ends in parallel and their output ends in series, so that the forward output voltage at the output end of the forward multiplication transmission unit is twice the forward input voltage;

[0016] The negative multiplication transmission unit includes: a first negative transmission cable and a second negative transmission cable. One end of the first negative transmission cable and one end of the second negative transmission cable are connected in parallel as the input end of the negative multiplication transmission unit, and the other end of the first negative transmission cable and the other end of the second negative transmission cable are connected in series as the output end of the negative multiplication transmission unit;

[0017] The first negative transmission cable and the second negative transmission cable can increase the negative transmission impedance by connecting their input ends in parallel and their output ends in series, so that the negative output voltage at the output end of the negative multiplication transmission unit is twice the negative input voltage.

[0018] Further, a first magnetic ring is provided on the first positive transmission cable, a second magnetic ring is provided on the second positive transmission cable, the core wire at one end of the first positive transmission cable is connected to the core wire of the second positive transmission cable, and the shielding layer at the other end of the first positive transmission cable is connected to the core wire at the other end of the second positive transmission cable;

[0019] A third magnetic ring is provided on the first negative transmission cable, a fourth magnetic ring is provided on the second negative transmission cable, the core wire at one end of the first negative transmission cable is connected to the core wire of the second negative transmission cable, and the shielding layer at the other end of the first negative transmission cable is connected to the core wire at the other end of the second negative transmission cable.

[0020] Further, the positive multiplication transmission unit includes: a first positive transmission cable and a second positive transmission cable. One end of the first positive transmission cable and one end of the second positive transmission cable are connected in series as the input end of the positive multiplication transmission unit, and the other ends of the first positive transmission cable and the second positive transmission cable are connected in parallel as the output end of the positive multiplication transmission unit;

[0021] The first positive transmission cable and the second positive transmission cable can reduce the positive transmission impedance by connecting their input ends in series and their output ends in parallel, so that the positive output current at the output end of the positive multiplication transmission unit is twice the positive input current;

[0022] The negative multiplication transmission unit includes: a first negative transmission cable and a second negative transmission cable. One end of the first negative transmission cable and one end of the second negative transmission cable are connected in series as the input end of the negative multiplication transmission unit, and the other ends of the first negative transmission cable and the second negative transmission cable are connected in parallel as the output end of the negative multiplication transmission unit;

[0023] The first negative transmission cable and the second negative transmission cable can reduce the negative transmission impedance by connecting their input ends in series and their output ends in parallel, so that the negative output current at the output end of the negative multiplication transmission unit is twice the negative input current.

[0024] Further, a first magnetic ring is provided on the first forward transmission cable, and a second magnetic ring is provided on the second forward transmission cable. The shielding layer at one end of the first forward transmission cable is connected to the core wire at one end of the second forward transmission cable, and the core wire at the other end of the first forward transmission cable is connected to the core wire at the other end of the second forward transmission cable;

[0025] A third magnetic ring is provided on the first negative transmission cable, and a fourth magnetic ring is provided on the second negative transmission cable. The shielding layer at one end of the first negative transmission cable is connected to the core wire at one end of the second negative transmission cable, and the core wire at the other end of the first negative transmission cable is connected to the core wire at the other end of the second negative transmission cable.

[0026] Further, the positive pulse transmission unit further includes a forward basic transmission unit. One end of the forward basic transmission unit is connected to the output end of the forward multiplication transmission unit, and the other end of the forward basic transmission unit is connected to the positive pulse output electrode wire. The forward basic transmission unit is configured to transmit the forward voltage or forward current multiplied by the forward multiplication transmission unit to the positive pulse output electrode wire;

[0027] The negative pulse transmission unit further includes a negative basic transmission unit. One end of the negative basic transmission unit is connected to the output end of the negative multiplication transmission unit, and the other end of the negative basic transmission unit is connected to the negative pulse output electrode wire. The negative basic transmission unit is configured to transmit the negative voltage or negative current multiplied by the negative multiplication transmission unit to the negative pulse output electrode wire.

[0028] Further, the positive pulse transmission unit further includes a forward output socket. The forward output socket is located between the forward multiplication transmission unit and the forward basic transmission unit. The input end of the forward output socket is respectively connected to the two forward transmission cables of the forward multiplication output unit, and the other end of the forward output socket is connected to the forward basic transmission unit;

[0029] The negative pulse transmission unit further includes a negative output socket. The negative output socket is located between the negative multiplication transmission unit and the negative basic transmission unit. The input end of the negative output socket is respectively connected to the two negative transmission cables of the negative multiplication output unit, and the other end of the negative output socket is connected to the negative basic transmission unit.

[0030] Further, the positive pulse charging unit includes: a first positive diode, a first positive inductor, and a first positive capacitor. The anodic end of the first positive diode is connected to the positive terminal of the power supply. The cathodic end of the first positive diode is connected to one end of the first positive inductor. The other end of the first positive inductor is connected to one end of the first positive capacitor. The other end of the first positive capacitor is connected to one end of the inductor at the power supply terminal. The other end of the inductor at the power supply terminal is connected to the negative terminal of the power supply;

[0031] The negative pulse charging unit includes: a first negative diode, a first negative inductor, and a first negative capacitor. The cathodic end of the first negative diode is connected to the positive terminal of the power supply. The anodic end of the first negative diode is connected to one end of the first negative inductor. The other end of the first negative inductor is connected to one end of the first negative capacitor. The other end of the first negative capacitor is connected to one end of the inductor at the power supply terminal. The other end of the inductor at the power supply terminal is connected to the negative terminal of the power supply.

[0032] Further, the positive pulse output control unit includes: a second positive capacitor, a positive resistor, and a positive synchronous controllable switch. One end of the second positive capacitor is connected to one end of the first positive capacitor. The other end of the second positive capacitor is connected to one end of the positive resistor. The other end of the positive resistor is connected to the positive multiplication transmission unit. One end of the positive synchronous controllable switch is connected to one end of the first positive capacitor. The other end of the positive synchronous controllable switch is connected to the positive multiplication transmission unit. The control end of the positive synchronous controllable switch is connected to one end of the positive resistor;

[0033] The negative pulse output control unit includes: a second negative capacitor, a negative resistor, and a negative synchronous controllable switch. One end of the second negative capacitor is connected to one end of the first negative capacitor. The other end of the second negative capacitor is connected to one end of the negative resistor. The other end of the negative resistor is connected to the negative multiplication transmission unit. One end of the negative synchronous controllable switch is connected to one end of the first negative capacitor. The other end of the negative synchronous controllable switch is connected to the negative multiplication transmission unit. The control end of the negative synchronous controllable switch is connected to one end of the negative resistor.

[0034] As another aspect of the present invention, there is provided an ablation device, which includes the bipolar nanosecond pulse synchronous output circuit described above.

[0035] The bipolar nanosecond pulse synchronous output circuit provided by the present invention charges to a preset positive threshold through the positive pulse charging unit in the positive pulse output circuit, then generates a positive output pulse signal through the positive pulse output control unit, and further multiplies the positive voltage or positive current of the positive output pulse signal through the positive pulse transmission unit, so that the instantaneous pulse energy of the positive pulse signal transmitted to the target through the positive pulse output electrode wire is increased. Similarly, the negative pulse output circuit increases the instantaneous pulse energy of the negative pulse signal reaching the target in the same way, and the positive pulse output circuit and the negative pulse output circuit can achieve bipolar nanosecond pulse synchronous output. Therefore, the bipolar nanosecond pulse synchronous output circuit can increase the instantaneous pulse energy of the nanosecond pulse tumor ablation device to achieve bipolar nanosecond pulse synchronous output, and the bipolar nanosecond pulse synchronous output circuit also has the advantages of high stability and low implementation cost. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] The accompanying drawings are used to provide a further understanding of the present invention, and constitute a part of the specification, and are used to explain the present invention together with the following specific embodiments, but do not constitute a limitation to the present invention.

[0037] Figure 1 It is a structural block diagram of the bipolar nanosecond pulse synchronous output circuit provided by the present invention.

[0038] Figure 2 It is a structural schematic diagram of the bipolar nanosecond pulse synchronous output circuit of the voltage doubling embodiment provided by the present invention.

[0039] Figure 3 It is a structural schematic diagram of the bipolar nanosecond pulse synchronous output circuit of the current doubling embodiment provided by the present invention.

[0040] Figure 4a It is an equivalent circuit diagram of the forward transmission cable impedance in the voltage doubling embodiment provided by the present invention.

[0041] Figure 4b It is an equivalent circuit diagram of the forward transmission cable impedance in the current doubling embodiment provided by the present invention.

[0042] Figure 5 It is a schematic diagram of the output pulse waveform of the bipolar nanosecond pulse synchronous output circuit provided by the present invention.

[0043] Figure 6 It is a schematic diagram of the specific implementation structure in the bipolar nanosecond pulse synchronous output circuit provided by the present invention.

[0044] Figure 7 It is a specific implementation circuit diagram of the current doubling of the bipolar nanosecond pulse synchronous output circuit provided by the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0045] It should be noted that, without conflict, the embodiments in the present invention and the features in the embodiments can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in conjunction with the embodiments.

[0046] In order to enable those skilled in the art to better understand the solution of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0047] It should be noted that the terms "first", "second", etc. in the specification and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects, and do not necessarily need to be used to describe a specific order or sequence. It should be understood that such data can be interchanged under appropriate circumstances so as to implement the embodiments of the present invention described herein. In addition, the terms "comprising" and "having" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device that includes a series of steps or units does not necessarily have to be limited to those clearly listed steps or units, but may include other steps or units not clearly listed or inherent to these processes, methods, products or devices.

[0048] In this embodiment, a bipolar nanosecond pulse synchronous output circuit is provided. Figure 1 is a structural block diagram of the bipolar nanosecond pulse synchronous output circuit provided according to the embodiment of the present invention, as Figure 1 shown, including:

[0049] a positive pulse output circuit 100 and a negative pulse output circuit 200, and the positive pulse output circuit 100 and the negative pulse output circuit 200 are electrically connected;

[0050] The positive pulse output circuit 100 includes a positive pulse charging unit 110, a positive pulse output control unit 120, a positive pulse transmission unit 130, and a positive pulse output electrode line 140 that are electrically connected in sequence;

[0051] The negative pulse output circuit 200 includes a negative pulse charging unit 210, a negative pulse output control unit 220, a negative pulse transmission unit 230, and a negative pulse output electrode line 240 that are electrically connected in sequence;

[0052] The positive pulse charging unit 110 is electrically connected to the negative pulse charging unit 210, and the positive pulse transmission unit 130 is electrically connected to the negative pulse transmission unit 230;

[0053] The positive pulse charging unit 110 is used to charge forward to a preset positive threshold, and the negative pulse charging unit 210 is used to charge backward to a preset negative threshold, and the absolute values of the preset positive threshold and the preset negative threshold are the same;

[0054] The positive pulse output control unit 120 is used to generate a forward output pulse signal when the positive pulse charging unit 110 charges to the preset positive threshold, and the negative pulse output control unit 220 is used to generate a negative-phase output pulse signal when the negative pulse charging unit 210 charges to the preset negative threshold;

[0055] The positive pulse transmission unit 130 at least includes a forward multiplication transmission unit 131 for multiplying the forward voltage or forward current of the forward output pulse signal; the negative pulse transmission unit 230 at least includes a backward multiplication transmission unit 231 for multiplying the backward voltage or backward current of the backward output pulse signal; the multiplication amplitude of the forward output pulse signal is the same as the multiplication amplitude of the backward output pulse signal;

[0056] The positive pulse output electrode wire 140 and the negative pulse output electrode wire 240 are used to synchronously output the multiplied output pulse signals to the target object.

[0057] In the embodiment of the present invention, by providing a forward multiplication transmission unit in the positive pulse transmission unit, the forward output pulse signal can be multiplied in forward voltage or forward current, so that the instantaneous pulse energy of the forward output pulse signal reaching the target object is increased, and by providing a backward multiplication transmission unit in the negative pulse transmission unit, the backward output pulse signal can be multiplied in backward voltage or backward current, so that the instantaneous pulse energy of the backward output pulse signal reaching the target object is increased, and the forward output pulse signal and the backward pulse output signal are synchronously output to form an electric field ablation zone in the target object, so that bipolar nanosecond pulse synchronous output can be realized.

[0058] Therefore, the bipolar nanosecond pulse synchronous output circuit provided by the present invention charges to a preset positive threshold through the positive pulse charging unit in the positive pulse output circuit, then generates a forward output pulse signal through the positive pulse output control unit, and further multiplies the forward voltage or forward current of the forward output pulse signal through the positive pulse transmission unit, so that the instantaneous pulse energy of the forward pulse signal transmitted to the target through the positive pulse output electrode wire is increased. Similarly, the negative pulse output circuit increases the instantaneous pulse energy of the negative pulse signal reaching the target in the same way, and the positive pulse output circuit and the negative pulse output circuit can achieve bipolar nanosecond pulse synchronous output. Therefore, the bipolar nanosecond pulse synchronous output circuit can increase the instantaneous pulse energy of the nanosecond pulse tumor ablation device to achieve bipolar nanosecond pulse synchronous output, and the bipolar nanosecond pulse synchronous output circuit also has the advantages of high stability and low implementation cost.

[0059] In the embodiment of the present invention, the positive pulse transmission unit 130 further includes a positive basic transmission unit 132. One end of the positive basic transmission unit 132 is connected to the output end of the positive multiplication transmission unit 131, and the other end of the positive basic transmission unit 132 is connected to the positive pulse output electrode wire 140. The positive basic transmission unit 132 is used to transmit the multiplied positive voltage or positive current of the positive multiplication transmission unit 131 to the positive pulse output electrode wire 140.

[0060] The negative pulse transmission unit 230 further includes a negative basic transmission unit 232. One end of the negative basic transmission unit 232 is connected to the output end of the negative multiplication transmission unit 231, and the other end of the negative basic transmission unit 232 is connected to the negative pulse output electrode wire 240. The negative basic transmission unit 232 is used to transmit the multiplied negative voltage or negative current of the negative multiplication transmission unit 231 to the negative pulse output electrode wire.

[0061] In the embodiment of the present invention, specifically as Figure 2 and Figure 3 shown, the positive basic transmission unit 132 includes a positive basic transmission cable 13, and the negative basic transmission unit 232 includes a negative basic transmission cable - 13.

[0062] It should be understood that by setting the positive basic transmission unit 132 and the negative basic transmission unit 232, not only can the extension of the transmission cable be realized to meet the requirements of different occasions, but also the separate packaging and disinfection of the electrode wire and the cable can be realized.

[0063] In an embodiment of the present invention, the positive pulse transmission unit 130 further includes a positive output socket 12, which is located between the positive multiplication transmission unit 131 and the positive basic transmission unit 132. The input end of the positive output socket 12 is respectively connected to two positive transmission cables of the positive multiplication output unit 131, and the other end of the positive output socket 12 is connected to the positive basic transmission unit 132;

[0064] The negative pulse transmission unit 230 further includes a negative output socket -12, which is located between the negative multiplication transmission unit 231 and the negative basic transmission unit 232. The input end of the negative output socket -12 is respectively connected to two negative transmission cables of the negative multiplication output unit 231, and the other end of the negative output socket -12 is connected to the negative basic transmission unit 232.

[0065] It should be understood that in an embodiment of the present invention, by providing a positive output socket in the positive pulse output circuit and a negative output socket in the negative pulse output circuit, the connection between the multiplication output unit and the basic transmission unit can be realized, and the output socket is usually arranged on the whole machine to facilitate the separate packaging and disinfection of the electrode wires and cables.

[0066] In an embodiment of the present invention, as Figure 2 and Figure 3 shown, the positive pulse charging unit 110 includes: a first positive diode 1, a first positive inductor 2, and a first positive capacitor 3. The anodic end of the first positive diode 1 is connected to the positive terminal of the power supply, the cathodic end of the first positive diode 1 is connected to one end of the first positive inductor 2, the other end of the first positive inductor 2 is connected to one end of the first positive capacitor 3, the other end of the first positive capacitor 3 is connected to one end of the power supply terminal inductor 4, and the other end of the power supply terminal inductor 4 is connected to the negative terminal of the power supply;

[0067] The negative pulse charging unit 210 includes: a first negative diode -1, a first negative inductor -2, and a first negative capacitor -3. The cathodic end of the first negative diode -1 is connected to the positive terminal of the power supply, the anodic end of the first negative diode -1 is connected to one end of the first negative inductor -2, the other end of the first negative inductor -2 is connected to one end of the first negative capacitor -3, the other end of the first negative capacitor -3 is connected to one end of the power supply terminal inductor 4, and the other end of the power supply terminal inductor 4 is connected to the negative terminal of the power supply.

[0068] In an embodiment of the present invention, a positive pulse charges a first positive capacitor through a first positive diode 1 and a first positive inductor 2, and a negative pulse charges a first negative capacitor -3 through a first negative diode -1 and a first negative inductor -2; when the charging reaches a preset threshold, the first positive capacitor 3 and the first negative capacitor -3 can discharge together with the power supply terminal inductor 4 to a positive pulse output control unit and a negative pulse output control unit.

[0069] In an embodiment of the present invention, as Figure 2 and Figure 3 shown, the positive pulse output control unit 120 includes: a second positive capacitor 5, a positive resistor 6, and a positive synchronous controllable switch 7. One end of the second positive capacitor 5 is connected to one end of the first positive capacitor 3, the other end of the second positive capacitor 5 is connected to one end of the positive resistor 6, the other end of the positive resistor 6 is connected to the positive multiplication transmission unit 131, one end of the positive synchronous controllable switch 7 is connected to one end of the first positive capacitor 3, the other end of the positive synchronous controllable switch 7 is connected to the positive multiplication transmission unit 131, and the control end of the positive synchronous controllable switch 7 is connected to one end of the positive resistor 6;

[0070] The negative pulse output control unit 220 includes: a second negative capacitor -5, a negative resistor -6, and a negative synchronous controllable switch -7. One end of the second negative capacitor -5 is connected to one end of the first negative capacitor -3, the other end of the second negative capacitor -5 is connected to one end of the negative resistor -6, the other end of the negative resistor -6 is connected to the negative multiplication transmission unit 231, one end of the negative synchronous controllable switch -7 is connected to one end of the first negative capacitor -3, the other end of the negative synchronous controllable switch -7 is connected to the negative multiplication transmission unit 231, and the control end of the negative synchronous controllable switch -7 is connected to one end of the negative resistor -6.

[0071] It should be understood that when the positive pulse charging unit 110 charges to a preset positive threshold, it discharges to the second positive capacitor, the positive resistor 6, and the positive synchronous controllable switch 7 to output a positive pulse voltage +V_in. Similarly, when the negative pulse charging unit 210 charges to a preset negative threshold, it discharges to the second negative capacitor -5, the negative resistor -6, and the negative synchronous controllable switch -7 to output a negative pulse voltage -V_in.

[0072] In an embodiment of the present invention, in order to improve the instantaneous pulse energy of the bipolar nanosecond pulse synchronous output circuit, as a specific implementation manner, as Figure 2As shown, the forward multiplication transmission unit 131 includes: a first forward transmission cable 8 and a second forward transmission cable 9. One end of the first forward transmission cable 8 is connected in parallel with one end of the second forward transmission cable 9 and serves as the input end of the forward multiplication transmission unit 131. The other end of the first forward transmission cable 8 is connected in series with the other end of the second forward transmission cable 9 and serves as the output end of the forward multiplication transmission unit 131;

[0073] The first forward transmission cable 8 and the second forward transmission cable 9 can increase the forward transmission impedance by connecting their input ends in parallel and their output ends in series, so that the forward output voltage at the output end of the forward multiplication transmission unit 131 is twice the forward input voltage;

[0074] The negative multiplication transmission unit 231 includes: a first negative transmission cable -8 and a second negative transmission cable -9. One end of the first negative transmission cable -8 is connected in parallel with one end of the second negative transmission cable -9 and serves as the input end of the negative multiplication transmission unit 231. The other end of the first negative transmission cable -8 is connected in series with the other end of the second negative transmission cable -9 and serves as the output end of the negative multiplication transmission unit 231;

[0075] The first negative transmission cable -8 and the second negative transmission cable -9 can increase the negative transmission impedance by connecting their input ends in parallel and their output ends in series, so that the negative output voltage at the output end of the negative multiplication transmission unit 231 is twice the negative input voltage.

[0076] It should be understood that in the embodiment of the present invention, the equivalent circuit diagram of the impedance of the first forward transmission cable and the second forward transmission cable is as Figure 4a shown. Based on this equivalent circuit diagram, it can be seen that after the impedance of the first forward transmission cable and the second forward transmission cable is matched, they are in series. Compared with only a single forward transmission cable, when the power remains unchanged, the impedance is increased by 4 times, so that the output voltage at the output end of the forward multiplication transmission unit is doubled, that is, the output voltage at the output end of the forward multiplication transmission unit is twice its forward input voltage; similarly, the negative output voltage at the output end of the negative multiplication transmission unit is twice the negative input voltage. Specifically, as Figure 4a shown, the input ends of two transmission lines with an impedance of Z0 are connected in parallel, the input voltage is V_in, the output ends of the two transmission lines are connected in series, and by designing the length of the transmission line (delay time τ = L / v, v is the wave velocity), the reflected waves of each section are synchronously superimposed at the output end, and the total output voltage is V_out = V_in + V_in = 2V_in. Since the input energy remains unchanged, at this time: the output current I_out = I_in / 2, and the load impedance is: Z_out = 4Z_in.

[0077] After the output voltages of both the positive multiplication transmission unit and the negative multiplication transmission unit are transmitted to their respective pulse output electrode lines, the obtained pulse width becomes narrower. Since the total energy remains unchanged, the narrowing of the pulse width results in an instant increase in energy, thereby enhancing the instant pulse energy of the pulsed tumor ablation device, and further achieving the purpose of enhancing the tumor ablation effect.

[0078] In the embodiment of the present invention, in order to adjust the cable distribution parameters finely and suppress the cable leakage interference, a first magnetic ring 10 is provided on the first positive transmission cable 8, a second magnetic ring 11 is provided on the second positive transmission cable 9, the core wire at one end of the first positive transmission cable 8 is connected to the core wire of the second positive transmission cable 9, and the shielding layer at the other end of the first positive transmission cable 8 is connected to the core wire at the other end of the second positive transmission cable 9;

[0079] A third magnetic ring -10 is provided on the first negative transmission cable -8, a fourth magnetic ring -11 is provided on the second negative transmission cable -9, the core wire at one end of the first negative transmission cable -8 is connected to the core wire of the second negative transmission cable -9, and the shielding layer at the other end of the first negative transmission cable -8 is connected to the core wire at the other end of the second negative transmission cable -9.

[0080] Specifically, as Figure 2 shown, multiple (8, 9, and -8, -9) cable lines with magnetic rings are arranged in pairs. The core wires of the cables (8 and 9) are connected in parallel to the output terminal +V_in of the positive pulse output control unit 120, and multiple shielding wires are connected in parallel; then, the core wire at the output end of the first positive transmission cable 8 is connected to the core wire of the positive output socket 12 as the positive pulse output +V_out = +2V_in; the core wire at the output end of the second positive transmission cable 9 is connected to the shielding layer of the first positive transmission cable 8 to form a series connection; similarly, the core wires of the negative transmission cables (-8, -9) are connected in parallel to the output terminal -V_in of the negative pulse output control unit 220, and the cable shielding wires are connected in parallel; then, the core wire at the output end of the first negative transmission cable -8 is connected to the core wire of the negative output socket -12 as the negative pulse output -V_out = -2V_in; the core wire at the output end of the second negative transmission cable -9 is connected to the shielding layer of the first negative transmission cable -8 to form a series connection; the shielding wires of the negative transmission cables (-8, -9) are connected together.

[0081] This double-voltage multiplier transmission unit in the embodiment of the present invention realizes that the positive pulse output voltage is twice the input voltage, i.e., V_out = 2×V_in, and the positive pulse current drops to half of the input end, I_out = I_in / 2; the output impedance rises to 4 times, Z_out = 4×Z_in2; similarly, the negative pulse output voltage is twice the input voltage, -V_out = -2×V_in, and the pulse current drops to half of the input end, -I_out = -I_in / 2; the output impedance rises to 4 times, Z_out = 4×Z_in; the overall machine pulse width T = 2L / V; the overall machine realizes bipolar nanosecond pulse synchronous double voltage and high-impedance output.

[0082] The ablation device formed by this embodiment can not only achieve high-energy ablation but also be widely applied in fields such as plasma sterilization and disinfection, neuromodulation, and rehabilitation.

[0083] In the embodiment of the present invention, in order to further improve the instantaneous pulse energy of the bipolar nanosecond pulse synchronous output circuit, as another specific implementation manner, as Figure 3 shown, the positive multiplier transmission unit 131 includes: a first positive transmission cable 8 and a second positive transmission cable 9. One end of the first positive transmission cable 8 and one end of the second positive transmission cable 9 are connected in series as the input end of the positive multiplier transmission unit 131, and the other ends of the first positive transmission cable 8 and the second positive transmission cable 9 are connected in parallel as the output end of the positive multiplier transmission unit 131;

[0084] The first positive transmission cable 8 and the second positive transmission cable 9 can reduce the positive transmission impedance by connecting their input ends in series and their output ends in parallel, so that the positive output current at the output end of the positive multiplier transmission unit 131 is twice the positive input current;

[0085] The negative multiplier transmission unit 231 includes: a first negative transmission cable -8 and a second negative transmission cable -9. One end of the first negative transmission cable -8 and one end of the second negative transmission cable -9 are connected in series as the input end of the negative multiplier transmission unit 231, and the other ends of the first negative transmission cable -8 and the second negative transmission cable -9 are connected in parallel as the output end of the negative multiplier transmission unit 231;

[0086] The first negative transmission cable -8 and the second negative transmission cable -9 can reduce the negative transmission impedance by connecting their input ends in series and their output ends in parallel, so that the negative output current at the output end of the negative multiplier transmission unit 231 is twice the negative input current.

[0087] It should be understood that in the embodiments of the present invention, the equivalent circuit diagrams of the impedances of the first forward transmission cable and the second forward transmission cable are as follows Figure 4b shown. It can be seen from this equivalent circuit diagram that after the impedances of the first forward transmission cable and the second forward transmission cable are matched, they are in parallel. Compared with only a single forward transmission cable, when the power remains unchanged, the impedance is reduced to 1 / 4 of the original, so that the output current at the output end of the forward multiplication transmission unit is doubled, that is, the output current at the output end of the forward multiplication transmission unit is twice its forward input current; similarly, the negative output current at the output end of the negative multiplication transmission unit is twice the negative input current. Specifically, as Figure 4b shown, the input ends of two transmission lines with an impedance of Z0 are connected in series, the input current I_in flows through the series loop, and the output ends of the two transmission lines are connected in parallel. By designing the length of the transmission lines (delay time τ = L / v, where v is the wave velocity), the reflected waves of each section are synchronously superimposed at the output end, and the total output current is I_out = I_in + I_in = 2I_in. Since the input energy remains unchanged, at this time: the output voltage V_out = V_in / 2, and the load impedance is: Z_out = Z_in / 4.

[0088] After the output currents of the forward multiplication transmission unit and the negative multiplication transmission unit are transmitted to their respective pulse output electrode lines, the obtained pulse width becomes narrower. Since the total energy remains unchanged, the narrowing of the pulse width results in an instantaneous increase in energy, thereby increasing the instantaneous pulse energy of the pulsed tumor ablation device, and further achieving the purpose of improving the tumor ablation effect.

[0089] It should be noted that in the embodiments of the present invention, since the impedance is reduced and closer to the human body impedance after reduction, the bipolar nanosecond pulse synchronous output circuit formed based on this method can effectively improve the ablation effect of the target when applied to the ablation device.

[0090] In the embodiments of the present invention, in order to fine-tune the cable distribution parameters and suppress the cable leakage interference, a first magnetic ring 10 is provided on the first forward transmission cable 8, a second magnetic ring 11 is provided on the second forward transmission cable 9, the shield layer at one end of the first forward transmission cable 8 is connected to the core wire at one end of the second forward transmission cable 9, and the core wire at the other end of the first forward transmission cable 8 is connected to the core wire at the other end of the second forward transmission cable 9;

[0091] A third magnetic ring -10 is provided on the first negative transmission cable -8, a fourth magnetic ring -11 is provided on the second negative transmission cable -9, the shield layer at one end of the first negative transmission cable -8 is connected to the core wire at one end of the second negative transmission cable -9, and the core wire at the other end of the first negative transmission cable -8 is connected to the core wire at the other end of the second negative transmission cable -9.

[0092] Specifically, as Figure 3 shown, multiple (8, 9 and -8, -9) magnet-ring-equipped cable wires are arranged in pairs. The input core wire of the first forward transmission cable 8 is connected to the output terminal +I_in of the positive pulse output control unit 120, and the input core wire of the second forward transmission cable 9 is connected to the shielding layer of the first forward transmission cable 8 to form a series connection; at the output end, the core wires of multiple (8, 9) cables are connected in parallel to the core wire of the positive output socket 12 as the positive pulse output +I_out = +2I_in, and the shielding wires of the cables (8, 9) are connected in parallel. In the same way, the input core wire of the first negative transmission cable -8 is connected to the output terminal -I_in of the negative pulse output control unit 220, and the input core wire of the second negative transmission cable -9 is connected to the shielding layer of the first negative transmission cable -8 to form a series connection; at the output end of the cable, the core wires of multiple (-8, -9) cables are connected in parallel to the core wire of the negative output socket -12 as the negative pulse output -I_out = -2I_in, and the shielding wires of the cables (-8, -9) are connected together.

[0093] This double-current multiplication transmission unit in the embodiment of the present invention realizes that the positive pulse output current is twice the input current, that is, I_out = 2×I_in, the positive pulse voltage drops to half of the input end V_out = V_in / 2; the output impedance is reduced by half Z_out = Z_in / 4; similarly, the negative pulse output current is twice the input current, that is, -I_out = -2×I_in, the negative pulse voltage drops to half of the input end -V_out = -V_in / 2; the negative output impedance is reduced by half Z_out = Z_in / 4.

[0094] The high-voltage pulse width output by the bipolar nanosecond pulse synchronous output circuit in the embodiment of the present invention is basically fixed and less than 600 ns. At the same time, the whole machine realizes bipolar nanosecond pulse synchronous double-current and low-impedance output. The instantaneous pulse current output by the whole machine can exceed 350 A. When this bipolar nanosecond pulse synchronous output circuit is applied to an ablation device, it can improve the ablation effect of the target object 15. Since the pulse width is less than 600 ns and the single-pulse energy is less than 1 J, the phenomena of human muscle twitching and electric tremor generated by discharge existing in the ablation of the microsecond-level PFA device are basically eliminated during the ablation of the target object, making it possible to use local anesthesia. As Figure 5 shown, it is the pulse waveform output by the bipolar nanosecond pulse synchronous output circuit in the embodiment of the present invention.

[0095] Next, in combination with Figure 6 and Figure 7 a detailed description of the specific implementation of the bipolar nanosecond pulse synchronous output circuit of the present invention will be given.

[0096] Taking Figure 3 the double-current embodiment shown as an example, for Figure 3The doubling transmission unit in it uses four cables, among which 2 cables output double current for positive pulses, and the other 2 cables output double current for negative pulses, finally achieving the result of bipolar synchronous short-pulse double current. The implementation principles are respectively as Figure 6 and Figure 7 shown. Specifically, it may include high-frequency high-voltage cable lines (101, 102, 103, 104), nanocrystalline magnetic rings (201, 202, 203, 204), magnetic ring fixing columns (301, 302, 303, 304), fixed long studs (401, 402), upper and lower covers (501, 502), and coaxial cable connection sockets (601, 602).

[0097] Through the high-frequency cable transmission line as Figure 7 shown, serial-parallel double current output is carried out (+I_out = +2×I_in, -I_out = -2×I_in). The instantaneous pulse current output by the whole machine can exceed 350A, and it has a good ablation effect in the ablation of the target object; the output pulse voltage is reduced by half (+V_out = +V_in / 2, -V_out = -V_in / 2), which reduces the withstand voltage test limit value of the medical device application part and also reduces the electromagnetic radiation interference of the whole machine.

[0098] In this embodiment, four high-frequency coaxial cables (101-104) are selected for the double current circuit of bipolar short pulses. The cable withstand voltage, outer diameter, core wire size, and impedance characteristics are selected according to actual needs. The high-frequency cable uses a double-layer shield of silver-plated copper wire braided mesh and aluminum film, and the characteristic impedance can be selected as 50Ω. The basis for selecting the length of the high-frequency cable: L = V×T / 2, (V represents the wave propagation speed, T represents the output pulse width).

[0099] As Figure 6 shown, it is the specific implementation structure of the embodiment of the present invention. In order to reduce the external radiation interference of the transmission cable line, nanocrystalline magnetic rings are arranged on each cable during design. The magnetic ring has the functions of high saturation magnetic induction intensity, high permeability, good common-mode suppression and harmonic filtering effect. The preferred model of the nanocrystalline magnetic ring is 1K107. The inner diameter of the magnetic ring is larger than the outer diameter of the cable, and the outer diameter of the magnetic ring is smaller than the inner diameter of the PVC fixing column; the length of the PVC fixing column is determined according to the length of the high-frequency cable line minus the exposed wire lengths at both ends used to connect the socket. In this embodiment of the present invention, a PVC pipe or stainless steel pipe with a length of 30 cm and an outer diameter of Φ50 is used, and a heat shrinkable tube is sleeved outside. Four Φ50 inner grooves are respectively opened on the upper and lower covers to position the 4 PVC pipes.

[0100] Specific installation process of the structure of the embodiment of the present invention: First, insert the magnetic rings (201 - 204) into the PVC pipe columns respectively, then move the PVC pipe columns one by one onto the 4 Φ50 inner grooves of the lower cover plate, straighten the pipe columns, cover the upper cover, press the upper and lower covers tightly after positioning, and finally fix the long studs (401 - 402) with screws respectively; then pass the high-frequency cables (101, 102) of the same length through the 2 PVC pipe columns on the left side of the current doubling fixing device respectively, pass the high-frequency cables (103, 104) of the same length through the 2 PVC pipe columns on the right side of the current doubling fixing device respectively, and connect the cables at the upper and lower ends of the fixing device according to the requirements of the current doubling circuit as shown in Figure 7 Connect the connections of the cables at the upper and lower ends of the fixing device as required by the current doubling circuit shown.

[0101] For the connection of the input end of the current doubling device at the lower part: Connect the core wire of the high-frequency cable 101 to the positive polarity output (+I_in), connect the shielding layer of the input end of the cable 101 to the core wire of the input end of the cable 102, connect and leave the shielding layers of the input ends of the cable 101 and the cable 102 suspended, and protect the core wire connection end and the suspended shielding layer with high-voltage heat shrinkable sleeves to form a series connection interface at the input end.

[0102] For the connection of the output end of the current doubling device at the upper part: Connect the core wires of the output ends of the high-frequency cables 101 and 102 in parallel and then connect them to the core wire of the coaxial socket (601). Connect and leave the shielding layers of the output ends of the 101 and 102 cables suspended. Protect the core wire connection end and the shielding layer with high-voltage heat shrinkable sleeves. The coaxial socket (601) serves as the positive high-voltage pulse output (+I_out = +2×I_in, +V_out = +V_in / 2).

[0103] Similarly, connect the core wire of the high-frequency cable 103 to the negative polarity output (-I_in) of the bipolar synchronous short pulse of the original patent. Connect the shielding layer of the input end of the cable 103 to the core wire of the input end of the cable 104. Connect and leave the shielding layers of the input ends of the cable 103 and the cable 104 suspended. Protect the core wire connection end and the suspended shielding layer with high-voltage heat shrinkable sleeves to form a series connection interface at the input end.

[0104] Connect the core wires of the output ends of the high-frequency cables 103 and 104 in parallel and then connect them to the core wire of the coaxial socket 602. Connect and leave the shielding layers of the output ends of the 103 and 104 cables suspended. Protect the core wire connection end and the shielding layer with high-voltage heat shrinkable sleeves. The coaxial socket 602 serves as the negative high-voltage pulse output (-I_out = -2×I_in, -V_out = -V_in / 2).

[0105] In summary, the bipolar nanosecond pulse synchronous output circuit provided by the present invention realizes voltage multiplication or current multiplication through the multiplication transmission unit, can improve the instantaneous pulse energy of the nanosecond pulse tumor ablation device to achieve bipolar nanosecond pulse synchronous output, and the bipolar nanosecond pulse synchronous output circuit also has the advantages of high stability and low implementation cost.

[0106] As another embodiment of the present invention, there is provided an ablation device, which includes the bipolar nanosecond pulse synchronous output circuit described above.

[0107] Since the ablation device provided by the present invention adopts the bipolar nanosecond pulse synchronous output circuit described above, it can have instantaneous pulse energy during the ablation of the target, thereby having an efficient and stable ablation effect.

[0108] Regarding the specific working principle of the ablation device according to the embodiment of the present invention, reference can be made to the description of the bipolar nanosecond pulse synchronous output circuit described above, and details are not described herein again.

[0109] It can be understood that the above embodiments are merely exemplary embodiments adopted to illustrate the principle of the present invention, and the present invention is not limited thereto. For those of ordinary skill in the art, various modifications and improvements can be made without departing from the spirit and essence of the present invention, and these modifications and improvements are also regarded as the protection scope of the present invention.

Claims

1. A bipolar nanosecond pulse synchronous output circuit, characterized in that: include: A positive pulse output circuit and a negative pulse output circuit, wherein the positive pulse output circuit and the negative pulse output circuit are electrically connected; The positive pulse output circuit comprises a positive pulse charging unit, a positive pulse output control unit, a positive pulse transmission unit and a positive pulse output electrode line which are electrically connected in sequence; The negative pulse output circuit comprises a negative pulse charging unit, a negative pulse output control unit, a negative pulse transmission unit and a negative pulse output electrode line which are electrically connected in sequence; The positive pulse charging unit is electrically connected to the negative pulse charging unit, and the positive pulse transmission unit is electrically connected to the negative pulse transmission unit; The positive pulse charging unit is used for positive charging to a preset positive threshold, and the negative pulse charging unit is used for negative charging to a preset negative threshold, and the absolute values ​​of the preset positive threshold and the preset negative threshold are the same; The positive pulse output control unit is used to generate a positive output pulse signal when the positive pulse charging unit is charged to a preset positive threshold, and the negative pulse output control unit is used to generate a negative phase output pulse signal when the negative pulse charging unit is charged to a preset negative threshold; The positive pulse transmission unit at least includes a positive multiplication transmission unit, which is used to multiply the positive voltage or the positive current of the positive output pulse signal; the negative pulse transmission unit at least includes a negative multiplication transmission unit, which is used to multiply the negative voltage or the negative current of the negative output pulse signal; the multiplication degree of the positive output pulse signal is the same as the multiplication degree of the negative output pulse signal; The positive pulse output electrode line and the negative pulse output electrode line are used to synchronously output their respective multiplied output pulse signals to a target object.

2. The bipolar nanosecond pulse synchronous output circuit according to claim 1, characterized in that: The forward multiplication transmission unit comprises: a first forward transmission cable and a second forward transmission cable, one end of the first forward transmission cable is connected in parallel with one end of the second forward transmission cable to serve as an input end of the forward multiplication transmission unit, and the other end of the first forward transmission cable is connected in series with the other end of the second forward transmission cable to serve as an output end of the forward multiplication transmission unit; The first forward transmission cable and the second forward transmission cable can increase the forward transmission impedance by connecting the input ends of the two cables in parallel and connecting the output ends of the two cables in series, so that the forward output voltage of the output end of the forward multiplication transmission unit is twice the forward input voltage; The negative multiplication transmission unit comprises: a first negative transmission cable and a second negative transmission cable, one end of the first negative transmission cable is connected in parallel with one end of the second negative transmission cable and serves as an input end of the negative multiplication transmission unit, and the other end of the first negative transmission cable is connected in series with the other end of the second negative transmission cable and serves as an output end of the negative multiplication transmission unit; The first negative transmission cable and the second negative transmission cable can increase the negative transmission impedance by connecting their input ends in parallel and their output ends in series, so that the negative output voltage of the output end of the negative multiplication transmission unit is twice the negative input voltage.

3. The bipolar nanosecond pulse synchronous output circuit according to claim 2, characterized in that: A first magnetic ring is provided on the first forward transmission cable, a second magnetic ring is provided on the second forward transmission cable, a core wire at one end of the first forward transmission cable is connected to a core wire of the second forward transmission cable, and a shielding layer at the other end of the first forward transmission cable is connected to a core wire at the other end of the second forward transmission cable; A third magnetic ring is arranged on the first negative transmission cable, a fourth magnetic ring is arranged on the second negative transmission cable, the core wire at one end of the first negative transmission cable is connected to the core wire of the second negative transmission cable, and the shielding layer at the other end of the first negative transmission cable is connected to the core wire at the other end of the second negative transmission cable.

4. The bipolar nanosecond pulse synchronous output circuit according to claim 1, characterized in that: The forward multiplication transmission unit comprises: a first forward transmission cable and a second forward transmission cable, one end of the first forward transmission cable and one end of the second forward transmission cable are connected in series to serve as an input end of the forward multiplication transmission unit, and the other end of the first forward transmission cable and the second forward transmission cable are connected in parallel to serve as an output end of the forward multiplication transmission unit; The first forward transmission cable and the second forward transmission cable can reduce the forward transmission impedance by connecting the input ends of the two cables in series and connecting the output ends of the two cables in parallel, so that the forward output current of the output end of the forward multiplication transmission unit is twice the forward input current; The negative multiplication transmission unit comprises: a first negative transmission cable and a second negative transmission cable, one end of the first negative transmission cable and one end of the second negative transmission cable are connected in series as an input end of the negative multiplication transmission unit, and the other end of the first negative transmission cable and the second negative transmission cable are connected in parallel as an output end of the negative multiplication transmission unit; The first negative transmission cable and the second negative transmission cable can reduce the negative transmission impedance by connecting their input ends in series and their output ends in parallel, so that the negative output current of the output end of the negative multiplication transmission unit is twice the negative input current.

5. The bipolar nanosecond pulse synchronous output circuit according to claim 4, characterized in that: A first magnetic ring is provided on the first forward transmission cable, a second magnetic ring is provided on the second forward transmission cable, a shielding layer at one end of the first forward transmission cable is connected to a core wire at one end of the second forward transmission cable, and a core wire at the other end of the first forward transmission cable is connected to a core wire at the other end of the second forward transmission cable; A third magnetic ring is arranged on the first negative transmission cable, and a fourth magnetic ring is arranged on the second negative transmission cable. The shielding layer at one end of the first negative transmission cable is connected to the core wire at one end of the second negative transmission cable, and the core wire at the other end of the first negative transmission cable is connected to the core wire at the other end of the second negative transmission cable.

6. The bipolar nanosecond pulse synchronous output circuit according to any one of claims 1 to 5, characterized in that: The positive pulse transmission unit further comprises a forward basic transmission unit, one end of which is connected to the output end of the forward multiplication transmission unit, and the other end of which is connected to the positive pulse output electrode line, and the forward basic transmission unit is used to transmit the forward voltage or forward current multiplied by the forward multiplication transmission unit to the positive pulse output electrode line; The negative pulse transmission unit also includes a negative basic transmission unit, one end of the negative basic transmission unit is connected to the output end of the negative multiplication transmission unit, and the other end of the negative basic transmission unit is connected to the negative pulse output electrode line. The negative basic transmission unit is used to transmit the negative voltage or negative current multiplied by the negative multiplication transmission unit to the negative pulse output electrode line.

7. The bipolar nanosecond pulse synchronous output circuit according to claim 6, characterized in that: The positive pulse transmission unit further comprises a forward output socket, the forward output socket being located between the forward multiplication transmission unit and the forward basic transmission unit, the input end of the forward output socket being respectively connected to two forward transmission cables of the forward multiplication output unit, and the other end of the forward output socket being connected to the forward basic transmission unit; The negative pulse transmission unit also includes a negative output socket, which is located between the negative multiplication transmission unit and the negative basic transmission unit. The input end of the negative output socket is respectively connected to two negative transmission cables of the negative multiplication output unit, and the other end of the negative output socket is connected to the negative basic transmission unit.

8. The bipolar nanosecond pulse synchronous output circuit according to any one of claims 1 to 5, characterized in that: The positive pulse charging unit comprises: a first positive diode, a first positive inductor and a first positive capacitor, wherein an anode end of the first positive diode is connected to a positive end of a power supply, a cathode end of the first positive diode is connected to one end of the first positive inductor, the other end of the first positive inductor is connected to one end of the first positive capacitor, the other end of the first positive capacitor is connected to one end of the inductor at the power supply end, and the other end of the inductor at the power supply end is connected to a negative end of a power supply; The negative pulse charging unit includes: a first negative diode, a first negative inductor and a first negative capacitor, the cathode end of the first negative diode is connected to the positive end of the power supply, the anode end of the first negative diode is connected to one end of the first negative inductor, the other end of the first negative inductor is connected to one end of the first negative capacitor, the other end of the first negative capacitor is connected to one end of the power supply end inductor, and the other end of the power supply end inductor is connected to the negative end of the power supply.

9. The bipolar nanosecond pulse synchronous output circuit according to claim 8, characterized in that: The positive pulse output control unit comprises: a second positive capacitor, a positive resistor and a positive synchronous controllable switch, one end of the second positive capacitor is connected to one end of the first positive capacitor, the other end of the second positive capacitor is connected to one end of the positive resistor, the other end of the positive resistor is connected to the forward multiplication transmission unit, one end of the positive synchronous controllable switch is connected to one end of the first positive capacitor, the other end of the positive synchronous controllable switch is connected to the forward multiplication transmission unit, and the control end of the positive synchronous controllable switch is connected to one end of the positive resistor; The negative pulse output control unit includes: a second negative capacitor, a negative resistor and a negative synchronous controllable switch, one end of the second negative capacitor is connected to one end of the first negative capacitor, the other end of the second negative capacitor is connected to one end of the negative resistor, the other end of the negative resistor is connected to the negative multiplication transmission unit, one end of the negative synchronous controllable switch is connected to one end of the first negative capacitor, the other end of the negative synchronous controllable switch is connected to the negative multiplication transmission unit, and the control end of the negative synchronous controllable switch is connected to one end of the negative resistor.

10. An ablation device, characterized in that: The invention comprises the bipolar nanosecond pulse synchronous output circuit as described in any one of claims 1 to 9.

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