Cream for promoting healing of oral mucosal skin

Abstract

The present application relates to the field of oral and skin health care technology, and specifically discloses a cream for promoting the healing of oral mucosal skin. The cream comprises the following raw materials in percentage by weight: 5-10% effective ingredient, 5-10% repair ingredient, 5-8% emulsifier, 3-5% stabilizer, 20-30% matrix, and the balance is deionized water; the effective ingredient comprises kiwi extract; the repair ingredient comprises hyaluronic acid; the emulsifier is a mixed stearate; the present application solves the technical problems that existing creams have a single function and are difficult to simultaneously meet the complex multi-stage and multi-target requirements in the healing process of oral mucosa and skin; the obtained cream can be simultaneously applied to the healing of skin and oral mucosa, and its indications include the healing of skin wounds such as burns, scalds, and scratches; the treatment of skin inflammations such as dermatitis and eczema; and the treatment of oral mucosa such as oral ulcers, oral mucositis, thrush, and erosive oral lichen planus, and has broad application prospects.

Description

Technical Field

[0001] The present application relates to the technical field of oral and skin health care, and more specifically, to a cream for promoting the healing of oral mucosal skin. Background Art

[0002] The oral mucosa and skin together form a crucial line of defense against harmful external agents, such as bacteria, viruses, and chemicals. As the first barrier between the human body and the external environment, the oral mucosa and skin are susceptible to damage from physical, chemical, and biological factors. Damage to the oral mucosa can easily lead to problems such as oral ulcers, oral mucositis, and oral mucosal lesions, while skin damage can lead to infections and scarring. Therefore, developing products that effectively promote the healing of the oral mucosa and skin is of great significance.

[0003] Creams are semisolid topical preparations that are delicate, soft, and easy to apply. They adhere evenly to the surface of the skin or mucous membranes, exerting a local therapeutic or protective effect. Creams are widely used in the pharmaceutical, cosmetic, and skincare sectors for treating skin diseases, promoting wound healing, moisturizing, and providing anti-inflammatory benefits. The diverse creams currently available on the market often focus on a single function (such as anti-inflammatory or antibacterial), failing to simultaneously address the complex multi-stage, multi-target needs of the oral mucosa and skin healing process. Existing skin creams are difficult to apply to both oral mucosa and skin due to their high irritation or unsuitable dosage forms, limiting their clinical application. Existing oral mucosal creams can only provide temporary relief for the symptoms of oral mucosal diseases and cannot offer a definitive treatment for specific types of oral mucosal diseases (such as oral ulcers, gingivitis, stomatitis, and oral mucosal lesions), resulting in limited long-lasting efficacy. Some creams contain specific drug ingredients (such as chlorhexidine), which can disrupt the balance of the oral microbiome with long-term use, leading to side effects such as oral mucosal discomfort, tooth staining, and taste changes. As people pay more and more attention to oral health and skin health, the market demand for creams that can promote the healing of oral mucosa and skin is increasing. Based on the above statement, the present application provides a cream that promotes the healing of oral mucosa and skin. Summary of the Invention

[0004] In order to solve the problems that existing creams focus on a single function and are difficult to simultaneously meet the complex multi-stage and multi-target needs of the oral mucosa and skin healing process, the present application provides a cream that promotes the healing of oral mucosa and skin.

[0005] The present application provides a cream for promoting healing of oral mucosal skin, which adopts the following technical solution:

[0006] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5-10% of an effective ingredient, 5-10% of a repairing ingredient, 5-8% of an emulsifier, 3-5% of a stabilizer, 20-30% of a base, and the balance being deionized water;

[0007] The effective component includes kiwi fruit extract; the repair component includes hyaluronic acid; and the emulsifier is mixed stearate.

[0008] Preferably, the effective ingredients further include Rabdosia rubescens extract, and the mass ratio of the kiwifruit extract to the Rabdosia rubescens extract is 3-5:1-2.

[0009] Preferably, the kiwifruit extract is prepared by the following method:

[0010] The kiwi fruit was washed, peeled, cut into pieces, and placed in a juicer. Water was added at a mass ratio of 1:1.5-2 to pulp the mixture. The supernatant was collected by centrifugation and concentrated to 30-40% of the original volume using a rotary evaporator to obtain a kiwi fruit extract.

[0011] Preferably, the Rubescens herb extract is prepared by the following method:

[0012] Dried Rubescens herb was crushed to obtain 80-100 mesh Rubescens herb fine powder;

[0013] The Rabdosia rubescens powder is mixed with ethanol water solution at a material-liquid mass ratio of 1:7-11, placed in an ultrasonic extractor, subjected to ultrasonic extraction, filtered, and the extract is concentrated to 50-60% of the original volume using a rotary evaporator to obtain a Rabdosia rubescens extract.

[0014] Preferably, the repair component further comprises green algae polysaccharide and aloe extract, and the mass ratio of the hyaluronic acid, green algae polysaccharide and aloe extract is 2-5:1-3:1-3.

[0015] Preferably, the mixed stearate comprises polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10-15:2-4:1.

[0016] Preferably, the stabilizer comprises lecithin and elemi oil in a mass ratio of 4-7:1-3.

[0017] Preferably, the matrix is ​​selected from at least one of liquid paraffin, beeswax, stearic acid, sodium stearate, hydrogenated castor oil, sesame oil, glycerin, and polyethylene glycol.

[0018] Preferably, the matrix comprises liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6-9:3-5:2-3:1.

[0019] A method for preparing a cream for promoting oral mucosal skin healing comprises the following steps:

[0020] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0021] S2. Mix the active ingredient and stabilizer and perform ultrasonic treatment until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain an oil phase. Add the repair ingredient to deionized water, heat to 70-75°C, and stir until completely dissolved to obtain an aqueous phase.

[0022] S3. Add the liposome structure to the oil phase, stir evenly, add the water phase and continue stirring evenly. After homogenization, the desired cream for promoting the healing of oral mucosal skin is obtained.

[0023] In summary, this application has the following beneficial effects:

[0024] The present application uses effective ingredients, repair ingredients, emulsifiers, stabilizers, matrix and deionized water to prepare a cream that promotes the healing of oral mucosa and skin, solving technical problems such as the single function of existing creams and the difficulty in simultaneously meeting the complex multi-stage and multi-target requirements of the oral mucosa and skin healing process. The effective ingredients are selected to achieve antibacterial, anti-inflammatory, antioxidant, astringent and healing-promoting effects. The repair ingredients are selected to promote wound healing. The stabilizer is used to improve the stability and permeability of the effective ingredients on the one hand, and the stability, adhesion and resistance to saliva dilution of the cream on the other hand. The selection of an emulsifier mixed with stearate can help mix the oil phase and the water phase to form a stable cream system, increase the viscosity of the cream, and improve its stability and adhesion. The preparation method of the cream of the present application is simple and the preparation conditions are mild. The resulting cream can be used for the healing of skin and oral mucosa at the same time. The indications include healing of skin wounds such as burns, scalds, and scratches; treatment of skin inflammations such as dermatitis and eczema; and treatment of oral mucosa such as oral ulcers, oral mucositis, thrush, and erosive oral lichen planus, and has broad application prospects.

[0025] The kiwi fruit extract of the present application is rich in vitamin C, natural organic acids and polyphenols, and has significant antibacterial, anti-inflammatory, soothing and antioxidant effects, which helps to relieve swelling and pain of mucous membranes and skin, reduce infection, and promote the healing and repair of oral mucosa and skin; the wintergrass extract has a broad-spectrum antibacterial effect, can inhibit the growth of pathogenic microorganisms, reduce inflammatory reactions, help reduce exudate, and can improve local blood circulation while inhibiting the release of inflammatory mediators to provide nutrition for the wound; using kiwi fruit extract and wintergrass extract together as effective ingredients, on the one hand, can significantly expand the antibacterial spectrum, enhance the ability to prevent and control wound infection, reduce inflammatory reactions around the wound, and shorten healing time; on the other hand, the two together can also accelerate cell proliferation and tissue regeneration, inhibit excessive fibrosis, reduce scar formation, and promote smooth repair of skin and mucous membranes.

[0026] This application uses hyaluronic acid, green algae polysaccharide and aloe extract as repair ingredients. Hyaluronic acid can promote cell proliferation and tissue regeneration, and accelerate wound healing; green algae polysaccharide has the effect of promoting collagen synthesis, accelerating tissue repair; aloe extract can promote cell proliferation and differentiation, and accelerate wound healing; the three together can significantly accelerate the tissue repair of skin and mucous membranes and shorten the healing time; the repair ingredients of the present invention can significantly enhance the repair effect of the cream through multiple mechanisms of action such as moisturizing, promoting repair, anti-inflammatory, anti-oxidation, and antibacterial; the synergistic effect of the three can not only accelerate wound healing, but also reduce scar formation, and is suitable for a variety of skin and oral mucosal indications.

[0027] This application uses a combination of lecithin and elemi oil as a stabilizer. Lecithin can form a thin film and enhance the adhesion of the cream on the oral mucosa. The terpene components in elemi oil can increase the viscosity of the cream, making it more firmly adhere to the mucosal surface. The two together can improve the film-forming property, hydrophobicity and dilution resistance of the cream, and prolong the onset time of the cream in the oral cavity. By pre-encapsulating the effective ingredients with a stabilizer to form a stable liposome structure, the stability and permeability of the effective ingredients can be significantly improved, thereby improving their bioavailability and enhancing the therapeutic effect.

[0028] This application uses liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil as a matrix, which has good permeability, moisturizing and astringent properties. It can not only provide the nutrients required by the skin and oral mucosa, accelerate wound healing and repair, but also protect the wound and prevent wound infection; the selection of the compound matrix of this application can effectively adjust the viscosity of the cream, making the cream easy to apply and absorb, and can form a protective film on the skin surface, providing a good release environment for the drug, while preventing external irritation and moisture loss, and protecting the wound from contamination. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1This is a general morphological diagram of the back wounds of rats in Example 1 and Comparative Examples 1-2 of the present application from initiation to healing.

[0030] Figure 2 This is a graph showing the changes in wound healing rates on the backs of rats in Example 1 and Comparative Examples 1-2 of the present application. DETAILED DESCRIPTION

[0031] The present application is further described in detail below with reference to the preparation examples and examples.

[0032] The raw materials used in the examples and comparative examples of this application are as follows:

[0033] Hyaluronic acid, particle size 80 mesh, content 99%, purchased from Qingdao Yuekang Biotechnology Co., Ltd.;

[0034] Chlorella polysaccharide, specification 10:1, mesh size 120, purchased from Ningxia Vanilla Biotechnology Co., Ltd.;

[0035] Aloe vera extract, CAS number 85507-69-3, specification 10:1, was purchased from Jiangsu Weizhirun Biotechnology Co., Ltd.;

[0036] Polyethylene glycol-7 stearate, content 99%, purchased from Hubei Xingyan New Material Technology Co., Ltd.;

[0037] Triglycerol monostearate, CAS No. 27321-72-8, was purchased from Jiangsu Jiujia Biotechnology Co., Ltd.;

[0038] Sorbitan tristearate, CAS 26658-19-5, was purchased from Jiangsu Jiujia Biotechnology Co., Ltd.;

[0039] Soybean lecithin, mesh size 120, was purchased from Hubei Haijia Biotechnology Co., Ltd.;

[0040] Elemi oil, CAS No. 9000-75-3, was purchased from Hubei Xinyuhong Biopharmaceutical Technology Co., Ltd.;

[0041] Liquid paraffin, CAS No. 8012-95-1, model CP2020, was purchased from Xi'an Tianzheng Pharmaceutical Excipients Co., Ltd.

[0042] White beeswax was purchased from Xi'an Green Biotechnology Co., Ltd.

[0043] Sesame oil was purchased from Xi'an Tianzheng Pharmaceutical Excipients Co., Ltd.

[0044] Hydrogenated castor oil, CAS No. 8001-78-3, was purchased from Xi'an Hongyao Pharmaceutical Excipients Co., Ltd.

[0045] Kiwi fruit extract was prepared by the following method:

[0046] Fresh Nanyang kiwifruit was washed, peeled, cut into pieces, and placed in a juicer. Water was added at a mass ratio of 1:1.5 to pulp the mixture, and the supernatant was collected by centrifugation. The centrifugal speed was controlled at 5000 rpm and the centrifugation time was 8 min. The supernatant was concentrated to 40% of the original volume using a rotary evaporator to obtain the kiwifruit extract.

[0047] The extract of Rubescens rubescens was prepared by the following method:

[0048] Place Rubescens rubescens in a hot air oven at 60°C and dry for 4 hours, then grind to obtain 100-mesh Rubescens rubescens powder;

[0049] The Rabdosia rubescens powder was mixed with 70% ethanol aqueous solution at a material-liquid mass ratio of 1:9, and the mixture was placed in an ultrasonic extractor. The ultrasonic power, ultrasonic frequency, ultrasonic temperature and ultrasonic time were set to 400 W, 32 kHz, 45°C and 30 min. After ultrasonic extraction, the extract was filtered through a 10 μm filter membrane to obtain the extract, and the extract was concentrated to 50% of the original volume using a rotary evaporator to obtain the Rabdosia rubescens extract.

[0050] Examples 1-3 provide a cream for promoting healing of oral mucosal skin. Example 1

[0051] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5% active ingredient, 5% repair ingredient, 5% emulsifier, 3% stabilizer, 20% base, and the balance being deionized water;

[0052] Among them, the effective ingredients include kiwi extract and wintergreen extract in a mass ratio of 3:1; the repair ingredients include hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soy lecithin and elemi oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0053] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0054] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0055] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 300 W, the ultrasonic frequency to 40 kHz, and the ultrasonic temperature to 75°C, and perform ultrasonic treatment for 20 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0056] S3. Add the liposome structure to the oil phase, control the stirring speed to 400 rpm, stir for 20 minutes until uniform, add the water phase and continue stirring for 20 minutes until uniform, control the homogenization speed to 8000 rpm, and homogenize for 5 minutes to obtain the desired cream for promoting oral mucosal skin healing. Example 2

[0057] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 8% of an effective ingredient, 6% of a repairing ingredient, 6.5% of an emulsifier, 4% of a stabilizer, 25% of a base, and the balance being deionized water;

[0058] Among them, the effective ingredients include kiwi extract and wintergreen extract in a mass ratio of 4:1.5; the repair ingredients include hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 3.5:2:2; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 12.5:3:1; the stabilizer includes soy lecithin and elemi oil in a mass ratio of 5.5:2; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 7.5:4:2.5:1.

[0059] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0060] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0061] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 350 W, the ultrasonic frequency to 35 kHz, and the ultrasonic temperature to 70°C, and perform ultrasonic treatment for 25 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0062] S3. Add the liposome structure to the oil phase, control the stirring speed to 500 rpm, stir for 15 minutes until uniform, add the water phase and continue stirring for 15 minutes until uniform, control the homogenization speed to 9000 rpm, and homogenize for 4 minutes to obtain the desired cream for promoting oral mucosal skin healing. Example 3

[0063] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 10% active ingredient, 10% repair ingredient, 8% emulsifier, 5% stabilizer, 30% base, and the balance being deionized water;

[0064] Among them, the effective ingredients include kiwi extract and wintergreen extract in a mass ratio of 5:2; the repair ingredients include hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 5:3:3; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 15:4:1; the stabilizer includes soy lecithin and oleaginous oil in a mass ratio of 7:3; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 9:5:3:1.

[0065] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0066] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0067] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 400 W, the ultrasonic frequency to 30 kHz, and the ultrasonic temperature to 65°C, and perform ultrasonic treatment for 30 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 75°C, and stir until completely dissolved to obtain the aqueous phase.

[0068] S3. Add the liposome structure to the oil phase, control the stirring speed to 600 rpm, stir for 10 minutes until uniform, add the water phase and continue stirring for 10 minutes until uniform, control the homogenization speed to 10000 rpm, and homogenize for 3 minutes to obtain the desired cream for promoting oral mucosal skin healing.

[0069] In order to verify the comprehensive effect of the cream for promoting oral mucosal skin healing prepared in Examples 1-3 of the present application, the applicant set up comparative examples 1-7, which are as follows: Comparative Example 1

[0070] Same as Example 1, except that only kiwi fruit extract is used as the active ingredient, specifically as follows:

[0071] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5% active ingredient, 5% repair ingredient, 5% emulsifier, 3% stabilizer, 20% base, and the balance being deionized water;

[0072] Among them, the active ingredient is kiwi extract; the repair ingredient includes hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soy lecithin and elemi oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0073] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0074] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0075] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 300 W, the ultrasonic frequency to 40 kHz, and the ultrasonic temperature to 75°C, and perform ultrasonic treatment for 20 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0076] S3. Add the liposome structure to the oil phase, control the stirring speed to 400 rpm, stir for 20 minutes until uniform, add the water phase and continue stirring for 20 minutes until uniform, control the homogenization speed to 8000 rpm, and homogenize for 5 minutes to obtain the desired cream for promoting oral mucosal skin healing. Comparative Example 2

[0077] Same as Example 1, except that only Rabdosia rubescens extract is used as the active ingredient, specifically as follows:

[0078] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5% active ingredient, 5% repair ingredient, 5% emulsifier, 3% stabilizer, 20% base, and the balance being deionized water;

[0079] Among them, the active ingredient is wintergreen extract; the repair ingredient includes hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soy lecithin and elemi oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0080] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0081] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0082] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 300 W, the ultrasonic frequency to 40 kHz, and the ultrasonic temperature to 75°C, and perform ultrasonic treatment for 20 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0083] S3. Add the liposome structure to the oil phase, control the stirring speed to 400 rpm, stir for 20 minutes until uniform, add the water phase and continue stirring for 20 minutes until uniform, control the homogenization speed to 8000 rpm, and homogenize for 5 minutes to obtain the desired cream for promoting oral mucosal skin healing. Comparative Example 3

[0084] Same as Example 1, except that only hyaluronic acid is used as the repair component, specifically as follows:

[0085] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5% active ingredient, 5% repair ingredient, 5% emulsifier, 3% stabilizer, 20% base, and the balance being deionized water;

[0086] Among them, the effective ingredients include kiwi extract and wintergreen extract in a mass ratio of 3:1; the repair ingredient is hyaluronic acid; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soybean lecithin and oleaginous oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0087] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0088] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0089] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 300 W, the ultrasonic frequency to 40 kHz, and the ultrasonic temperature to 75°C, and perform ultrasonic treatment for 20 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0090] S3. Add the liposome structure to the oil phase, control the stirring speed to 400 rpm, stir for 20 minutes until uniform, add the water phase and continue stirring for 20 minutes until uniform, control the homogenization speed to 8000 rpm, and homogenize for 5 minutes to obtain the desired cream for promoting oral mucosal skin healing. Comparative Example 4

[0091] The same as Example 1, except that the repair components are hyaluronic acid and chlorella polysaccharide in a mass ratio of 3:1, as follows:

[0092] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5% active ingredient, 5% repair ingredient, 5% emulsifier, 3% stabilizer, 20% base, and the balance being deionized water;

[0093] Among them, the effective ingredients include kiwi extract and wintergreen extract in a mass ratio of 3:1; the repair ingredients include hyaluronic acid and chlorella polysaccharide in a mass ratio of 3:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soy lecithin and oleaginous oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0094] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0095] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0096] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 300 W, the ultrasonic frequency to 40 kHz, and the ultrasonic temperature to 75°C, and perform ultrasonic treatment for 20 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0097] S3. Add the liposome structure to the oil phase, control the stirring speed to 400 rpm, stir for 20 minutes until uniform, add the water phase and continue stirring for 20 minutes until uniform, control the homogenization speed to 8000 rpm, and homogenize for 5 minutes to obtain the desired cream for promoting oral mucosal skin healing. Comparative Example 5

[0098] The same as Example 1, except that the repairing ingredients are hyaluronic acid and aloe extract in a mass ratio of 3:1, as follows:

[0099] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5% active ingredient, 5% repair ingredient, 5% emulsifier, 3% stabilizer, 20% base, and the balance being deionized water;

[0100] Among them, the effective ingredients include kiwi extract and wintergreen extract in a mass ratio of 3:1; the repair ingredients include hyaluronic acid and aloe extract in a mass ratio of 3:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer includes soy lecithin and oleaginous oil in a mass ratio of 4:1; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0101] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0102] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0103] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 300 W, the ultrasonic frequency to 40 kHz, and the ultrasonic temperature to 75°C, and perform ultrasonic treatment for 20 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0104] S3. Add the liposome structure to the oil phase, control the stirring speed to 400 rpm, stir for 20 minutes until uniform, add the water phase and continue stirring for 20 minutes until uniform, control the homogenization speed to 8000 rpm, and homogenize for 5 minutes to obtain the desired cream for promoting oral mucosal skin healing. Comparative Example 6

[0105] Same as Example 1, except that only soybean lecithin is used as the stabilizer, specifically as follows:

[0106] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5% active ingredient, 5% repair ingredient, 5% emulsifier, 3% stabilizer, 20% base, and the balance being deionized water;

[0107] Among them, the effective ingredients include kiwi extract and wintergreen extract in a mass ratio of 3:1; the repair ingredients include hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer is soy lecithin; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0108] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0109] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0110] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 300 W, the ultrasonic frequency to 40 kHz, and the ultrasonic temperature to 75°C, and perform ultrasonic treatment for 20 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0111] S3. Add the liposome structure to the oil phase, control the stirring speed to 400 rpm, stir for 20 minutes until uniform, add the water phase and continue stirring for 20 minutes until uniform, control the homogenization speed to 8000 rpm, and homogenize for 5 minutes to obtain the desired cream for promoting oral mucosal skin healing. Comparative Example 7

[0112] The same as Example 1, except that only elemi oil is used as the stabilizer, specifically as follows:

[0113] A cream for promoting healing of oral mucosal skin, comprising the following raw materials in percentage by weight: 5% active ingredient, 5% repair ingredient, 5% emulsifier, 3% stabilizer, 20% base, and the balance being deionized water;

[0114] Among them, the effective ingredients include kiwi extract and wintergreen extract in a mass ratio of 3:1; the repair ingredients include hyaluronic acid, chlorella polysaccharide and aloe extract in a mass ratio of 2:1:1; the emulsifier is a mixed stearate, specifically including polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10:2:1; the stabilizer is oleaginous oil; the matrix includes liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6:3:2:1.

[0115] A cream for promoting healing of oral mucosal skin is prepared by the following method:

[0116] S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use;

[0117] S2. After mixing the active ingredients and stabilizer, set the ultrasonic power to 300 W, the ultrasonic frequency to 40 kHz, and the ultrasonic temperature to 75°C, and perform ultrasonic treatment for 20 minutes until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain the oil phase. Add the repair component to deionized water, heat to 70°C, and stir until completely dissolved to obtain the aqueous phase.

[0118] S3. Add the liposome structure to the oil phase, control the stirring speed to 400 rpm, stir for 20 minutes until uniform, add the water phase and continue stirring for 20 minutes until uniform, control the homogenization speed to 8000 rpm, and homogenize for 5 minutes to obtain the desired cream for promoting oral mucosal skin healing.

[0119] Performance Testing

[0120] The therapeutic effects of the oral mucosal skin healing-promoting creams prepared in Examples 1-3 and Comparative Examples 1-7 of the present application on oral ulcers were tested respectively.

[0121] 1. Rat Oral Ulcer Healing Experiment

[0122] Experimental content: A total of 36 clean-grade SD rats (weighing 280-320 g) were randomly divided into 12 groups, with 3 rats in each group, and named as Example 1-3 and Comparative Example 1-7 groups, a model group, and a blank control group.

[0123] Before modeling, rats were given free access to food and water and were housed for one week to adapt. Rats from Examples 1-3, Comparative Examples 1-7, and the model group were subjected to chemical burning of the buccal mucosa with glacial acetic acid to establish the model. Specifically, the rats were anesthetized with an intraperitoneal injection of sodium pentobarbital (1% concentration, 0.5 ml / 100 g). Afterward, the rats' mouths were pulled open with cotton thread. A fixed-size mold was created using a 200-μl pipette tip. A small amount of cotton balls were placed into the mold, and 15 μl of 80% glacial acetic acid was absorbed. After the cotton balls were allowed to absorb, the mold was placed on the labial mucosa of the anesthetized rats for 30 seconds (chemical burning of the epithelial mucosa). Residual glacial acetic acid was then removed, and the immediate reaction at the treated site was recorded. The rats were numbered at the tail end and housed normally for 24 hours. The rats were then observed for the formation of ulcers in the oral mucosa. A blank control group was not subjected to modeling. Compared with the blank control group, the oral ulcer wounds in each group were more pronounced, with a yellowish-white pseudomembrane covering the ulcer surface, indicating successful model establishment.

[0124] 24 hours after modeling, the rats in the Example 1-3 and Comparative Example 1-7 groups were treated with the oral mucosal skin healing-promoting cream (0.05 g) prepared in Examples 1-3 and Comparative Example 1-7 of the present application, respectively. The model group was treated with a normal saline patch twice daily, with an 8-hour interval between treatments. The gross morphology of the ulcer was regularly observed and recorded daily from the onset to the healing of the ulcer. Treatment was continued until the ulcer was completely healed. The number of days for oral ulcer healing is shown in Table 1 below.

[0125] Table 1:

[0126]

[0127] The data shown in Table 1 above show that the ulcer surface healing of the cream for promoting oral mucosal skin healing prepared in Examples 1-3 is significantly better than that of Comparative Examples 1-7 and the model group, and the oral mucosal healing effect is significant and worthy of promotion.

[0128] 2. Rat Back Wound Healing Experiment

[0129] Experimental content: A total of 30 clean-grade SD rats (weighing 280-320 g) were randomly divided into 10 groups of 3 rats each, designated as Examples 1-3 and Comparative Examples 1-7. The hair on the backs of the rats was shaved and cleaned with a depilatory cream. Circular cross-sections were then cut to create skin defect models on the backs of the mice.

[0130] 24 hours after modeling, the rats in the Example 1-3 and Comparative Example 1-7 groups were treated with the oral mucosal skin healing-promoting cream (0.1 g) prepared in Examples 1-3 and Comparative Example 1-7, respectively. The residual wound area was observed and recorded daily. Treatment was continued until the wound was completely healed. The number of days to wound healing is shown in Table 2 below.

[0131] Table 2:

[0132]

[0133] From the above Table 2 and Figure 1-2 The data show that the back wound healing of the cream for promoting oral mucosal skin healing prepared in Examples 1-3 is significantly better than that of Comparative Examples 1-7, and the skin healing effect is significant and worthy of promotion.

[0134] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but as long as they are within the scope of the claims of the present application, they are protected by the patent law.

Claims

1. A cream for promoting healing of oral mucosa and skin, characterized in that: The composition comprises the following raw materials in the following weight percentages: 5-10% of an effective ingredient, 5-10% of a repairing ingredient, 5-8% of an emulsifier, 3-5% of a stabilizer, 20-30% of a matrix, and the balance being deionized water; The active ingredients are kiwi fruit extract and Rubescens rubescens extract in a mass ratio of 3-5:1-2; The repairing ingredients are hyaluronic acid, green algae polysaccharide and aloe extract in a mass ratio of 2-5:1-3:1-3; The emulsifier is a mixed stearate; The stabilizer is lecithin and elemi oil in a mass ratio of 4-7:1-3.

2. The cream for promoting oral mucosa and skin healing according to claim 1, characterized in that The kiwi fruit extract is prepared by the following method: The kiwi fruit was washed, peeled, cut into pieces, and placed in a juicer. Water was added at a mass ratio of 1:1.5-2 to pulp the mixture. The supernatant was collected by centrifugation and concentrated to 30-40% of the original volume using a rotary evaporator to obtain a kiwi fruit extract.

3. The cream for promoting oral mucosa and skin healing according to claim 1, characterized in that The Rabdosia rubescens extract is prepared by the following method: Dried Rubescens herb was crushed to obtain 80-100 mesh Rubescens herb fine powder; The Rabdosia rubescens powder is mixed with ethanol water solution at a material-liquid mass ratio of 1:7-11, placed in an ultrasonic extractor, subjected to ultrasonic extraction, filtered, and the extract is concentrated to 50-60% of the original volume using a rotary evaporator to obtain a Rabdosia rubescens extract.

4. The cream for promoting healing of oral mucosa and skin according to claim 1, characterized in that The mixed stearate comprises polyethylene glycol-7 stearate, triglycerol monostearate and sorbitan tristearate in a mass ratio of 10-15:2-4:

1.

5. The cream for promoting healing of oral mucosa and skin according to claim 1, characterized in that The matrix is ​​selected from at least one of liquid paraffin, beeswax, stearic acid, hydrogenated castor oil, sesame oil, glycerin, and polyethylene glycol.

6. The cream for promoting healing of oral mucosa and skin according to claim 5, characterized in that The matrix comprises liquid paraffin, white beeswax, sesame oil and hydrogenated castor oil in a mass ratio of 6-9:3-5:2-3:

1.

7. A method for preparing the cream for promoting healing of oral mucosa and skin according to any one of claims 1 to 6, characterized in that: The method comprises the following preparation steps: S1. Weigh the raw material functional ingredients, repair ingredients, emulsifier, stabilizer, matrix and deionized water according to weight percentage for later use; S2. Mix the active ingredient and stabilizer and perform ultrasonic treatment until fully dispersed to form a liposome structure. Mix the matrix and emulsifier, heat until completely melted, and stir to mix evenly to obtain an oil phase. Add the repair ingredient to deionized water, heat to 70-75°C, and stir until completely dissolved to obtain an aqueous phase. S3. Add the liposome structure to the oil phase, stir evenly, add the water phase and continue stirring evenly. After homogenization, the desired cream for promoting the healing of oral mucosa and skin is obtained.

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