Traditional Chinese medicine composition, medical fixing patch containing traditional Chinese medicine composition and preparation method of medical fixing patch

Abstract

The invention provides a traditional Chinese medicine composition, a medical fixing patch containing the traditional Chinese medicine composition and a preparation method of the medical fixing patch, and relates to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition comprises a component I and a component II, wherein the component I comprises 30-50 parts of angelica sinensis, 10-15 parts of amomum tsao-ko, 5-10 parts of astragalus membranaceus, 60-100 parts of clove oil, 8-12 parts of lemon eucalyptus and 15-30 parts of sesame oil; a component II: 50-65 parts of wintergreen oil, 5-10 parts of eucalyptus oil, 5-10 parts of litsea cubeba oil, 5-10 parts of camphor oil, 30-50 parts of menthol and 5-10 parts of borneol; the weight ratio of the component I to the component II is (1.2-1.5): 1; the traditional Chinese medicine composition is applied to an acupuncture point through a medical fixing patch, has the effects of promoting and restoring consciousness, takes effect quickly, also has the effects of warming and removing moisture and can effectively relieve fatigue, and the medical fixing patch has good perspiration resistance and still keeps good viscosity after meeting water, sweat, interstitial fluid and the like.

Description

Technical Field

[0001] The present application relates to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition, a medical fixation patch containing the traditional Chinese medicine composition, and a preparation method thereof. Background Art

[0002] Fatigue is a systemic reaction in the physiological category, mainly manifested as physical drowsiness, mental exhaustion, decreased attention, reduced work efficiency, etc. General fatigue is caused by excessive physical exertion such as physical labor and sports, and fatigue can be reduced or eliminated through rest, sleep, etc. In addition, long-term living in a hot and humid environment is likely to cause the spleen's transportation function to be blocked or the spleen to be unhealthy in transportation, and it will also show physical drowsiness, heaviness, weakness, easy fatigue, etc.

[0003] When the body shows drowsiness and inability to concentrate, generally, coffee or strong tea is drunk, essential balm is applied to quickly achieve the effect of refreshing the mind, or central nervous system stimulants such as methylphenidate, meclofenoxate, piracetam, modafinil, etc. are taken. Among them, coffee or strong tea contains caffeine. The main function of caffeine is to excite the central nervous system, which can improve the thinking ability of the brain and eliminate fatigue to achieve the purpose of refreshing the mind. However, while refreshing the mind, it will make people in a continuously excited state, causing physical energy overdraft. Once stopped, the physical fatigue will be more serious, and it will also affect sleep and make it difficult to fall asleep; Essential balm has high irritation, and its cooling effect generally bursts instantly and then drops sharply and is difficult to last; Central nervous system stimulants such as methylphenidate hydrochloride tablets are likely to cause many adverse reactions such as loss of appetite, nausea, diarrhea, insomnia, etc.

[0004] Traditional Chinese medicine usually has the effects of treating both the symptoms and the root causes and being safe without toxic and side effects. Therefore, developing a traditional Chinese medicine composition with the effects of refreshing the mind and relieving fatigue is of great significance. Patent CN202210789356.2 discloses a traditional Chinese medicine composition, a non-allergic transdermal patch containing the composition, and a preparation method thereof. The traditional Chinese medicine active substance prepared by using licorice, tangerine peel, artemisia annua, mugwort, notopterygium root, peppermint oil, centella asiatica, albizia flower, and styrax has good drug permeability and no allergic phenomenon, and has the effect of refreshing the mind. However, its short-term effect is slow, and it needs to be used for a long time to exert an obvious refreshing effect; In addition, this transdermal patch is applied with a hot-melt pressure-sensitive adhesive, and its viscosity decreases and it is easy to fall off after contacting sweat, reducing the contact time between the drug and the skin, resulting in the inability to well exert the drug's efficacy. Summary of the Invention

[0005] The purpose of the present application is to provide a traditional Chinese medicine composition, a medical fixing patch containing the traditional Chinese medicine composition and a preparation method thereof in view of the deficiencies of the prior art. The traditional Chinese medicine composition is applied to acupoints through the medical fixing patch, has the efficacy of enhancing mental clarity, quick effect, and at the same time has the efficacy of warming and expelling dampness and enhancing immunity, can effectively relieve fatigue, and the medical fixing patch has good sweat resistance and still maintains good adhesiveness after encountering water, sweat, tissue fluid, etc.

[0006] To achieve the above object, the technical solutions adopted in the present application are as follows:

[0007] According to one aspect of the present application, there is provided a traditional Chinese medicine composition, which includes, by weight:

[0008] Component I: 30-50 parts of angelica, 10-15 parts of tsaoko fruit, 5-10 parts of astragalus membranaceus, 60-100 parts of clove oil, 8-12 parts of lemon eucalyptus, 15-30 parts of sesame oil;

[0009] Component II: 50-65 parts of wintergreen oil, 5-10 parts of eucalyptus oil, 5-10 parts of litsea cubeba oil, 5-10 parts of camphor oil, 30-50 parts of menthol and 5-10 parts of borneol;

[0010] Among them, the weight ratio of Component I to Component II is (1.2-1.5):1.

[0011] The present application prepares a traditional Chinese medicine composition by using the above several medicinal materials in a specific ratio. Applying it to acupoints can achieve the efficacy of enhancing mental clarity, can effectively relieve fatigue, and also has the efficacy of warming and expelling dampness, can remove the dampness in the body, thereby relieving fatigue. The clinical trial effect is remarkable, and it is safe, non-irritating and has no side effects. It is found through experiments that the ratio of Component I to Component II is crucial for the traditional Chinese medicine composition to achieve the above effects. When the weight ratio of Component I to Component II is (1.2-1.5):1, it can simultaneously meet the effects of refreshing the mind and warming and expelling dampness.

[0012] Furthermore, the weight ratio of the angelica to the tsaoko fruit and the astragalus membranaceus is 10:(3-4):(1-1.4). It is found through experiments that the angelica, tsaoko fruit and astragalus membranaceus are the key to the traditional Chinese medicine composition to play the roles of refreshing the mind and warming and expelling dampness. When the ratio of the three is 10:(3-3.5):(1-1.4), not only can the best effects of refreshing the mind and warming and expelling dampness be exerted, but also the stability of the traditional Chinese medicine composition is good and the effect lasts for a long time.

[0013] Furthermore, the extraction method of the angelica, tsaoko fruit and astragalus membranaceus includes the following steps:

[0014] (1) Crushing and mixing the angelica, tsaoko fruit and astragalus membranaceus to obtain dry powder;

[0015] (2) Adding the dry powder to water for extraction and filtering to obtain a first extract and medicinal residues;

[0016] (3) Add the medicinal residues to water, add a composite enzyme for enzymatic hydrolysis, boil and sterilize after enzymatic hydrolysis, and filter to obtain a second extract.

[0017] (4) Mix the first extract and the second extract, perform spray drying, pulverize, and sieve to obtain a mixed extract.

[0018] Furthermore, in step (2), the amount of water used is 15 - 20 times the weight of the dry powder; the extraction temperature is 60 - 80°C and the time is 3 - 6 h.

[0019] Furthermore, in step (3), the amount of water used is 10 - 20 times the weight of the medicinal residues, and the total amount of the composite enzyme is 2 - 3% of the weight of the medicinal residues, both calculated based on the dry weight of the medicinal residues; the composite enzyme is cellulase, hemicellulase, and β - glucosidase with a weight ratio of 10:(2 - 4):(1 - 2); the enzymatic hydrolysis conditions are: pH = 4 - 5, temperature 45 - 55°C, and time 2 - 4 h.

[0020] After water extraction, there are still certain active ingredients remaining in the Angelica sinensis, Amomum tsaoko, and Astragalus membranaceus medicinal residues. In this application, a composite enzyme of cellulase, hemicellulase, and β - glucosidase is used for enzymatic hydrolysis. The three enzymes cooperate with each other, which can promote the re - release of active ingredients in the medicinal residues, thereby improving the extraction of polysaccharides and flavonoids, increasing the content of active ingredients in the medical fixation patch, and enhancing its medicinal efficacy.

[0021] Furthermore, the particle size of the mixed extract is 100 - 200 mesh.

[0022] As a further solution, in step (2), the water also contains tea polyphenols, and the weight ratio of water to tea polyphenols is (95 - 98):(2 - 5); when using a mixed solvent of water and tea polyphenols for extraction, the amount of the mixed solvent used is 10 - 20 times the weight of the dry powder; the extraction temperature is 60 - 75°C and the time is 3 - 4 h.

[0023] Research findings show that during the alcohol extraction process, the addition of tea polyphenols helps to break down cell walls, promote the release of polysaccharides, and inhibit the degradation of polysaccharides, thereby improving the extraction of polysaccharides. The addition of tea polyphenols can also increase the interaction with flavonoids to a certain extent, thus enhancing their solubility in water and improving the extraction efficiency, and further increasing the content of active ingredients in the medical fixation patch. In addition, the addition of tea polyphenols can prevent the degradation or damage of polysaccharides and flavonoids during the long-term storage of the traditional Chinese medicine composition, improving the storage stability of the traditional Chinese medicine composition. Although excessive use of tea polyphenols can improve the extraction of active ingredients such as polysaccharides and flavonoids, verification shows that the content of active ingredients of polysaccharides and flavonoids is not the higher the better. After the content of active ingredients increases to a certain extent, it will instead lead to a decline in the effects of refreshing the mind or warming and expelling dampness, and excessive addition of tea polyphenols will also have a certain impact on the exertion of drug efficacy. Therefore, it is necessary to control the extraction conditions of Angelica sinensis, Amomum tsaoko, and Astragalus membranaceus so that the content of flavonoids in the product after mixing Angelica sinensis, Amomum tsaoko, Astragalus membranaceus with the remaining medicinal materials is not higher than 2 mg / g, and the total polysaccharide content is lower than 24 mg / g, thereby ensuring the content of active ingredients in the drug-loading layer of the medical fixation patch and ensuring that the traditional Chinese medicine composition can better exert the effects of refreshing the mind and warming and expelling dampness.

[0024] According to another aspect of the present application, the preparation method of the above-mentioned traditional Chinese medicine composition includes the following steps:

[0025] Extract the mixed extract from Angelica sinensis, Amomum tsaoko, and Astragalus membranaceus, and mix it evenly with clove oil, lemon eucalyptus oil, sesame oil, wintergreen oil, eucalyptus oil, litsea cubeba oil, camphor oil, menthol, and borneol to obtain the product.

[0026] According to still another aspect of the present application, a medical fixation patch containing the traditional Chinese medicine composition includes a drug-loading layer, a backing layer, and a protective film layer; the drug-loading layer includes the above-mentioned traditional Chinese medicine composition, a pressure-sensitive adhesive, and sepiolite.

[0027] Further, the backing layer is a high-elastic non-woven fabric.

[0028] Further, the protective film layer is a release film or a siliconized paper.

[0029] Further, the weight ratio of the traditional Chinese medicine composition, the pressure-sensitive adhesive, and sepiolite is 1:(3 - 9):(0.07 - 0.1).

[0030] Further, the pressure-sensitive adhesive is a hot-melt pressure-sensitive adhesive.

[0031] Further, the sepiolite is a combination of two particle sizes. The particle size I is 150 - 200 mesh, the particle size II is 350 - 400 mesh, and the weight ratio is 1:(2 - 3). In this application, sepiolite is blended with the traditional Chinese medicine composition and the pressure - sensitive adhesive to prepare the drug - carrying layer. By reasonably matching the two particle - size dimensions and ratio of sepiolite, on the one hand, the pore structure of sepiolite can, to a certain extent, increase the moisture absorption and perspiration ability and improve the sweat resistance; on the other hand, more channels can be formed, which can well realize the absorption and transmission of moisture in the channels, improve the moisture - discharging effect, increase the comfort and sweat resistance of the medical fixation patch, and avoid falling off after encountering water or sweat, resulting in the inability of the drug to continuously exert its effect, thus affecting the treatment effect and prolonging the treatment cycle; in addition, the pore structure of sepiolite can adsorb some components in the traditional Chinese medicine composition, wrap them inside or on the surface of the voids, play a certain protective role, and improve its stability.

[0032] Furthermore, 5 - 7% of 4 - methylacrylamidosalicylic acid is also loaded on the surface of the sepiolite; the loading method is: dipping the sepiolite in an ethanol solution of 4 - methylacrylamidosalicylic acid, and drying it after dipping is completed.

[0033] In this application, sepiolite is modified with 4 - methylacrylamidosalicylic acid. The dispersibility of the modified sepiolite is improved. It can not only change the structure of the pressure - sensitive adhesive to form a certain void structure, which is more conducive to the transmission of sweat, enabling the sweat to be discharged more efficiently, thus further improving the moisture absorption and perspiration performance, but also helps to improve the viscosity of the pressure - sensitive adhesive; however, the loading amount of 4 - methylacrylamidosalicylic acid needs to be controlled. If the loading amount of 4 - methylacrylamidosalicylic acid is too much, the voids will be reduced, which will instead reduce the sweat resistance and is not conducive to the wrapping or adsorption of the traditional Chinese medicine composition by sepiolite, resulting in a decrease in stability.

[0034] According to another aspect of the present application, the preparation method of the above - mentioned medical fixation patch containing a traditional Chinese medicine composition includes the following steps:

[0035] S1. Mix the molten pressure - sensitive adhesive, the traditional Chinese medicine composition, and sepiolite evenly, and charge inert gas for pressurization to obtain the drug - carrying layer mixture.

[0036] S2. Coat the drug - carrying layer mixture on the backing layer, and then compound it with the protective film layer to obtain the medical fixation patch containing a traditional Chinese medicine composition.

[0037] In this application, sepiolite can be first mixed evenly with the traditional Chinese medicine composition and then mixed with the pressure - sensitive adhesive, or sepiolite and the traditional Chinese medicine composition can be added to the pressure - sensitive adhesive at the same time for mixing; to make sepiolite, the traditional Chinese medicine composition, and the pressure - sensitive adhesive mix evenly, methods well - known to those skilled in the art such as stirring and ultrasonic treatment can be used to assist in mixing.

[0038] Compared with the prior art, the present application has the following beneficial effects:

[0039] 1. The medical fixing patch containing the traditional Chinese medicine composition of the present application enhances the efficacy of refreshing the mind, and at the same time has the efficacy of warming and expelling dampness, thereby effectively alleviating physical fatigue, and can also enhance immunity. The clinical trial effect is remarkable, and it is safe, non-irritating and has no side effects.

[0040] 2. The medical fixing patch containing the traditional Chinese medicine composition of the present application is prepared by using several medicinal materials in a specific ratio. Applying it on acupoints can effectively relieve fatigue, achieve the efficacy of refreshing the mind, and at the same time has the efficacy of warming and expelling dampness, thereby effectively alleviating physical fatigue, and can also enhance the body's immunity, and will not affect the sleep quality, making up for the defect that the existing refreshing drugs affect sleep.

[0041] 3. The medical fixing patch containing the traditional Chinese medicine composition of the present application enzymatically hydrolyzes Angelica sinensis, tsaoko fruit and Astragalus membranaceus with a specific proportion of composite enzyme, and controls the enzymatic hydrolysis conditions to make the content of flavonoids in the traditional Chinese medicine composition range from 6.2 to 8.5 mg / g and the total polysaccharide content from 40.3 to 52.8 mg / g, so that the traditional Chinese medicine composition can better exert the effects of refreshing the mind, warming and expelling dampness, and enhancing immunity.

[0042] 4. The medical fixing patch containing the traditional Chinese medicine composition of the present application also adds sepiolite to the drug-loading layer, which can improve the water resistance of the medical fixing patch and keep good adhesiveness after encountering water, sweat and tissue fluid. Detailed implementation mode

[0043] The following non-limiting examples can enable those of ordinary skill in the art to more comprehensively understand the present application, but do not limit the present application in any way. The following content is only an exemplary illustration of the scope claimed in the present application. Those skilled in the art can make various changes and modifications to the application of the present application according to the disclosed content, and it should also fall within the scope claimed in the present application.

[0044] All kinds of chemical reagents used in the embodiments of the present application are obtained through conventional commercial channels without special instructions. Among them, cellulase, hemicellulase and β-glucosidase are all purchased from Shanghai Huashang Xiangyang Biotechnology Co., Ltd.; 4-methylacrylamidosalicylic acid (CAS: 50512-48-6) is purchased from Shanghai Fuzhe Chemical Industry Co., Ltd.; the pressure-sensitive adhesive is purchased from Foshan Shunde Qigu Hot Melt Adhesive Co., Ltd., model 1331, and can also be replaced with other hot-melt type pressure-sensitive adhesives; the protective film layer is a PET release film, purchased from Dongguan Hongwanxin Rubber Products Technology Co., Ltd., with a thickness of 0.1 mm; the high-elastic non-woven fabric is purchased from Pinghu Zhanpeng Hot Melt Adhesive Co., Ltd., product number LM-0007, and the gram weight is 75 g / m 2It is understandable that the above-mentioned solvent-based acrylate pressure-sensitive adhesives, protective film layers, backing layer materials, etc. can also be replaced with other conventional materials in this field, without special limitations.

[0045] The present application will be further described below by way of specific embodiments.

[0046] Example 1

[0047] A traditional Chinese medicine composition, calculated by weight, includes: Component I: 50 parts of Angelica sinensis, 10 parts of tsaoko fruit, 5 parts of Astragalus membranaceus, 100 parts of clove oil, 8 parts of Eucalyptus citriodora, 15 parts of sesame oil; Component II: 50 parts of wintergreen oil, 5 parts of eucalyptus oil, 5 parts of litsea cubeba oil, 5 parts of camphor oil, 50 parts of menthol, and 10 parts of borneol; the weight ratio of Component I to Component II is 1.5:1.

[0048] The traditional Chinese medicine composition is prepared by the following method:

[0049] S1. Extraction of Angelica sinensis, tsaoko fruit, and Astragalus membranaceus

[0050] (1) Crush Angelica sinensis, tsaoko fruit, and Astragalus membranaceus separately, mix them to obtain dry powder;

[0051] (2) Add the dry powder to 10 times the weight of water, extract at 60 °C for 6 h, filter to obtain the first extract and medicinal residues;

[0052] (3) Add the medicinal residues to 10 times the weight of water, add 2% of the dry weight of the medicinal residues of the composite enzyme, enzymatically hydrolyze at pH = 5 and 45 °C for 4 h, boil and sterilize after enzymatic hydrolysis, filter to obtain the second extract; the composite enzyme is cellulase, hemicellulase, and β-glucosidase with a weight ratio of 10:2:1;

[0053] (4) Mix the first extract and the second extract, spray dry, crush, and sieve to obtain a mixed extract with a particle size of 150 mesh;

[0054] S2. Mix the mixed extract with clove oil, Eucalyptus citriodora, sesame oil, wintergreen oil, eucalyptus oil, litsea cubeba oil, camphor oil, menthol, and borneol evenly to obtain the product.

[0055] Example 2

[0056] Another traditional Chinese medicine composition, calculated by weight, includes: Component I: 30 parts of Angelica sinensis, 15 parts of tsaoko fruit, 10 parts of Astragalus membranaceus, 60 parts of clove oil, 12 parts of Eucalyptus citriodora, 30 parts of sesame oil; Component II: 65 parts of wintergreen oil, 10 parts of eucalyptus oil, 10 parts of litsea cubeba oil, 10 parts of camphor oil, 30 parts of menthol, and 5 parts of borneol; the weight ratio of Component I to Component II is 1.2:1.

[0057] The traditional Chinese medicine composition is prepared by the following method:

[0058] S1. Extraction of Angelica sinensis, tsaoko fruit and Astragalus membranaceus

[0059] (1) Crush Angelica sinensis, tsaoko fruit and Astragalus membranaceus respectively, mix them to obtain dry powder;

[0060] (2) Add the dry powder to water at 20 times its weight, extract at 80 °C for 3 h, filter to obtain the first extract and medicinal residues;

[0061] (3) Add the medicinal residues to water at 20 times their weight, add a composite enzyme at 3% of the dry weight of the medicinal residues, carry out enzymatic hydrolysis at pH = 4 and 55 °C for 2 h, boil and sterilize after enzymatic hydrolysis, filter to obtain the second extract; the composite enzyme is cellulase, hemicellulase and β-glucosidase with a weight ratio of 10:4:2;

[0062] (4) Mix the first extract and the second extract, carry out spray drying, crushing, and sieving to obtain a mixed extract with a particle size of 150 mesh;

[0063] S2. Mix the mixed extract evenly with clove oil, lemon eucalyptus oil, sesame oil, wintergreen oil, eucalyptus oil, litsea cubeba oil, camphor oil, menthol and borneol to obtain a product.

[0064] Example 3

[0065] Another traditional Chinese medicine composition, by weight, includes: Component I: 50 parts of Angelica sinensis, 15 parts of tsaoko fruit, 10 parts of Astragalus membranaceus, 100 parts of clove oil, 10 parts of lemon eucalyptus oil, 20 parts of sesame oil; Component II: 50 parts of wintergreen oil, 5 parts of eucalyptus oil, 5 parts of litsea cubeba oil, 5 parts of camphor oil, 50 parts of menthol and 10 parts of borneol; the weight ratio of Component I to Component II is 1.64:1.

[0066] The preparation method of this traditional Chinese medicine composition is the same as that of Example 1.

[0067] Example 4

[0068] Another traditional Chinese medicine composition, by weight, includes: Component I: 50 parts of Angelica sinensis, 10 parts of tsaoko fruit, 5 parts of Astragalus membranaceus, 60 parts of clove oil, 10 parts of lemon eucalyptus oil, 15 parts of sesame oil; Component II: 55 parts of wintergreen oil, 5 parts of eucalyptus oil, 10 parts of litsea cubeba oil, 5 parts of camphor oil, 50 parts of menthol and 10 parts of borneol; the weight ratio of Component I to Component II is 1.11:1.

[0069] The preparation method of this traditional Chinese medicine composition is the same as that of Example 1.

[0070] Example 5

[0071] Another traditional Chinese medicine composition, by weight, includes: Component I: 50 parts of Angelica sinensis, 15 parts of tsaoko fruit, 5 parts of Astragalus membranaceus, 100 parts of clove oil, 8 parts of Eucalyptus citriodora, 15 parts of sesame oil; Component II: 50 parts of wintergreen oil, 8 parts of eucalyptus oil, 5 parts of Litsea cubeba oil, 5 parts of camphor oil, 50 parts of menthol, and 10 parts of borneol; The weight ratio of Component I to Component II is 1.5:1, that is, the weight ratio of Angelica sinensis, tsaoko fruit, and Astragalus membranaceus is 10:3:1.

[0072] The preparation method of this traditional Chinese medicine composition is the same as that of Example 1.

[0073] Example 6

[0074] Another traditional Chinese medicine composition, by weight, includes: Component I: 36 parts of Angelica sinensis, 14.4 parts of tsaoko fruit, 5 parts of Astragalus membranaceus, 100 parts of clove oil, 8 parts of Eucalyptus citriodora, 15 parts of sesame oil; Component II: 50 parts of wintergreen oil, 5 parts of eucalyptus oil, 5 parts of Litsea cubeba oil, 5 parts of camphor oil, 44 parts of menthol, and 10 parts of borneol; The weight ratio of Component I to Component II is 1.5:1, that is, the weight ratio of Angelica sinensis, tsaoko fruit, and Astragalus membranaceus is approximately 10:4:1.4.

[0075] The preparation method of this traditional Chinese medicine composition is the same as that of Example 1.

[0076] Example 7

[0077] The difference from Example 1 is that the complex enzyme is cellulase, hemicellulase, and β-glucosidase with a weight ratio of 10:1:3.

[0078] Example 8

[0079] The difference from Example 1 is that the complex enzyme is cellulase, hemicellulase, and β-glucosidase with a weight ratio of 10:5:0.5.

[0080] Example 9

[0081] The difference from Example 1 is that the complex enzyme does not contain β-glucosidase.

[0082] Example 10

[0083] The difference from Example 1 is that the complex enzyme does not contain hemicellulase.

[0084] Example 11

[0085] The difference from Example 1 is that the β-glucosidase in the complex enzyme is replaced with an equal amount of pectinase.

[0086] Example 12

[0087] The difference from Example 5 is that step (2) of the extraction of Angelica sinensis, tsaoko fruit and Astragalus membranaceus is as follows: adding the dry powder to a mixed solvent of water and tea polyphenols at 10 times the weight, extracting at 60 °C for 4 h, filtering to obtain a first extract and medicinal residues; the weight ratio of tea polyphenols to water is 2:98.

[0088] Example 13

[0089] The difference from Example 5 is that step (2) of the extraction of Angelica sinensis, tsaoko fruit and Astragalus membranaceus is as follows: adding the dry powder to a mixed solvent of water and tea polyphenols at 20 times the weight, extracting at 75 °C for 3 h, filtering to obtain a first extract and medicinal residues; the weight ratio of tea polyphenols to water is 5:95.

[0090] Example 14

[0091] The difference from Example 13 is that the weight ratio of tea polyphenols to water is 10:90.

[0092] Example 15

[0093] The difference from Example 13 is that the extraction temperature is 80 °C and the extraction time is 6 h.

[0094] Example 16

[0095] A medical fixing patch containing a traditional Chinese medicine composition, comprising a drug-loading layer, a backing layer and a protective film layer;

[0096] The backing layer is a high-elastic non-woven fabric;

[0097] The protective film layer is a PET release film;

[0098] The drug-loading layer comprises a traditional Chinese medicine composition (i.e., the product obtained in Example 1 above) with a weight ratio of 1:3:0.07, a pressure-sensitive adhesive and sepiolite;

[0099] Sepiolite is a combination of two particle sizes of particle size I and particle size II with a weight ratio of 1:3, particle size I is 150 mesh and particle size II is 350 mesh.

[0100] The medical fixing patch containing the traditional Chinese medicine composition is prepared by the following method:

[0101] S1. Mix the molten pressure-sensitive adhesive with the traditional Chinese medicine composition and sepiolite evenly, and charge nitrogen under pressure to obtain a drug-loading layer mixture;

[0102] S2. Coat the drug-loading layer mixture on the backing layer, and then laminate it with the protective film layer to obtain a medical fixing patch containing the traditional Chinese medicine composition.

[0103] Example 17

[0104] Another medical fixing patch containing a traditional Chinese medicine composition, comprising a drug-loading layer, a backing layer and a protective film layer;

[0105] The backing layer is a high-elastic non-woven fabric;

[0106] The protective film layer is a PET release film;

[0107] The drug-loading layer comprises a traditional Chinese medicine composition (i.e., the product obtained in Example 2 above) with a weight ratio of 1:9:0.1, a pressure-sensitive adhesive, and sepiolite;

[0108] Sepiolite is a combination of two particle sizes of particle size I and particle size II with a weight ratio of 1:2. Particle size I is 200 mesh, and particle size II is 400 mesh.

[0109] The preparation method of the medical fixing patch containing the traditional Chinese medicine composition is the same as that in Example 16.

[0110] Example 18

[0111] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 3.

[0112] Example 19

[0113] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 4.

[0114] Example 20

[0115] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 5.

[0116] Example 21

[0117] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 6.

[0118] Example 22

[0119] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 7.

[0120] Example 23

[0121] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 8.

[0122] Example 24

[0123] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 9.

[0124] Example 25

[0125] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 10.

[0126] Example 26

[0127] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 11.

[0128] Example 27

[0129] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 12.

[0130] Example 28

[0131] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 13.

[0132] Example 29

[0133] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 14.

[0134] Example 30

[0135] The difference from Example 16 is that the traditional Chinese medicine composition is the product obtained in Example 15.

[0136] Example 31

[0137] The difference from Example 16 is that the weight ratio of the amount of sepiolite used to the traditional Chinese medicine composition is 0.15:1.

[0138] Example 32

[0139] The difference from Example 16 is that sepiolite is a combination of two particle sizes, particle size I and particle size II, with a weight ratio of 1:5. Particle size I is 150 mesh and particle size II is 350 mesh.

[0140] Example 33

[0141] The difference from Example 16 is that sepiolite is a combination of two particle sizes, particle size I and particle size II, with a weight ratio of 2:1. Particle size I is 150 mesh and particle size II is 350 mesh.

[0142] Example 34

[0143] The difference from Example 16 is that the particle size of sepiolite is only 150 mesh.

[0144] Example 35

[0145] The difference from Example 16 is that the particle size of sepiolite is only 350 mesh.

[0146] Example 36

[0147] The difference from Example 16 is that the sepiolite is sepiolite surface-treated with 4-methacrylamidosalicylic acid. The surface treatment method is as follows: The sepiolite is impregnated in an ethanol solution (mass fraction 10%) of 4-methacrylamidosalicylic acid at 20 times the weight, and after impregnation, it is dried to obtain the product. The loading amount of 4-methacrylamidosalicylic acid on the sepiolite surface is 5%.

[0148] Example 37

[0149] The difference from Example 36 is that the loading amount of 4-methacrylamidosalicylic acid on the sepiolite surface is 7%.

[0150] Example 38

[0151] The difference from Example 36 is that the loading amount of 4-methacrylamidosalicylic acid on the sepiolite surface is 10%.

[0152] Example 39

[0153] The difference from Example 36 is that 4-methacrylamidosalicylic acid is replaced with an equal amount of acrylamide.

[0154] Example 40

[0155] The difference from Example 16 is that sepiolite is not added to the drug-loading layer.

[0156] Test Example 1

[0157] 1 g of the products in Examples 1 - 15 above were respectively taken and dissolved in 10 ml of water to obtain test solutions, and the contents of total flavonoids and total polysaccharides in the test solutions were detected. The detection results are shown in Table 1 below.

[0158] Table 1

[0159] Group Total flavonoids (mg / 10 ml) Total polysaccharides (mg / 10 ml) Example 1 1.68 20.85 Example 2 1.50 20.09 Example 3 1.65 22.19 Example 4 1.82 21.65 Example 5 1.84 23.50 Example 6 1.50 19.81 Example 7 1.58 18.66 Example 8 1.61 18.23 Example 9 1.45 15.86 Example 10 1.59 17.85 Example 11 1.55 17.19 Example 12 1.92 22.96 Example 13 1.96 23.18 Example 14 2.07 25.22 Example 15 2.05 24.16

[0160] As shown in the data in the table, the dosages of Angelica sinensis, tsaoko fruit and Astragalus membranaceus in Examples 1-6 are different, so the contents of total flavonoids and total polysaccharides in the products are different. Compared with Example 1, the raw materials used in Examples 7 and 8 are the same, but the proportions of the composite enzyme are different. In Examples 9 and 10, only two enzymes are used for enzymatic hydrolysis, and the contents of total flavonoids and total polysaccharides in the obtained products decrease; moreover, the β-glucosidase in Example 11 is replaced with pectinase. Although the use of pectinase or β-glucosidase alone can promote the dissolution of polysaccharides and flavonoids when extracting Angelica sinensis, tsaoko fruit and Astragalus membranaceus, it is verified that when pectinase is used in combination with cellulase and hemicellulase, it cannot promote the extraction of polysaccharides and flavonoids from the medicinal residues, indicating that when cellulase, hemicellulase and β-glucosidase are used to enzymatically hydrolyze Angelica sinensis, tsaoko fruit and Astragalus membranaceus in a specific proportion, it is beneficial to promote the extraction of active ingredients, thereby improving the medicinal efficacy. The results in Examples 12-15 show that adding tea polyphenols during the water extraction process of Angelica sinensis, tsaoko fruit and Astragalus membranaceus helps to promote the extraction of polysaccharides and flavonoids, but the dosage of tea polyphenols and the extraction conditions need to be controlled.

[0161] Test Example 2

[0162] Since the medical fixation patch is not used immediately after preparation, the medical fixation patch used by patients is generally stored for a certain period of time, and the active ingredients in the medical fixation patch will inevitably decrease during storage, thus affecting its medicinal efficacy. In this test example, each test solution in Test Example 1 was placed at 40 °C for 6 months, and then the degradation rates of the contents of total polysaccharides and total saponins in the test solution were detected to evaluate the stability and long-acting property of the traditional Chinese medicine composition. The lower the degradation rates of the contents of total polysaccharides and total saponins, the more active substances are retained and the better its medicinal efficacy. And according to the above method, the degradation rates of the contents of total polysaccharides and total saponins in the drug-loading layers of Examples 16, 27 and Examples 36-40 were tested.

[0163] The formula for calculating the degradation rate is: (C0 - C1) / C0 × 100%, where C0 is the initial content of total polysaccharides or total saponins in the test solution, and C1 is the final content of total polysaccharides or total saponins in the test solution after being placed for 6 months.

[0164] The degradation rate results of the contents of total polysaccharides and total saponins are shown in Table 2 below.

[0165] Table 2

[0166]

[0167]

[0168] As shown in the table, after the obtained products of all examples were placed for 6 months, the contents of total flavonoids and total polysaccharides decreased to varying degrees.

[0169] Examples 1 - 15 are about the changes in the active ingredients of the traditional Chinese medicine composition during long - term storage. It can be seen from Examples 1 - 11 that, compared with other examples, after the products obtained in Examples 1, 2, 5 and 6 are stored for 6 months, the total flavonoid content decreases by less than 7% and the total polysaccharide content decreases by less than 8.5%. In particular, for the products obtained in Examples 5 and 6, the total flavonoid only decreases by about 3.6% and the total polysaccharide content only decreases by about 5.7%, showing excellent stability, indicating that the traditional Chinese medicine composition provided in this application has good stability. Compared with Example 5, the decrease rate of the active ingredients in Examples 12 and 13 is reduced, indicating that adding a certain amount of tea polyphenols during the water extraction process will be retained in the product, which helps to improve the stability of the traditional Chinese medicine composition.

[0170] Examples 16, 27 and Examples 36 - 40 test the changes in the content of active ingredients in the drug - loaded layer. Compared with Example 1, pressure - sensitive adhesive and sepiolite are added to the drug - loaded layer in Example 16, and sepiolite is not added in Example 40. However, the decrease rate of the active ingredients in Example 16 is lower than that in Examples 1 and 40. From this, it can be seen that the addition of sepiolite helps to improve the stability of the traditional Chinese medicine composition, reduce the degradation of active ingredients during storage, and thus extend the drug efficacy time. Compared with Example 16, the surface of sepiolite in Examples 36 - 38 is load - treated, and the stability of the traditional Chinese medicine composition is improved to some extent. However, if the loading amount is too much, it will instead lead to a decrease in stability.

[0171] Test Example 3

[0172] (I) Hypersensitivity test

[0173] Take 125 healthy mice and divide them into 25 groups evenly. Shave the hair on the left and right sides of the mouse abdomen, taking care not to damage the skin. The hair - removal area on both sides is 3 cm × 3 cm; during the test, the left hair - removal area of the same mouse is used as the blank control group, smeared with physiological saline and fixed with gauze, and the right side is pasted with the medical fixation patches obtained in Examples 16 - 40 above. After pasting for 12 h, clean the test area and observe and record whether the mice show allergic reactions such as erythema and edema. The test results show that none of the mice show erythema and edema reactions, indicating that the medical fixation patches prepared in the examples of this application have mild drug properties and no adverse skin irritation.

[0174] (II) Refreshing test

[0175] Select 480 volunteers aged 25 - 35 who have been engaged in office writing work for a long time and are prone to dozing off during the day. The male - female ratio is 1:1, and they are evenly divided into 16 groups. At 2 p.m. every day, apply a medical fixation patch on both temple areas of the volunteers, and each application lasts for 2 hours. Among them, the volunteers in groups 1 - 15 are applied with the medical fixation patch prepared in Examples 16 - 30 above, and the volunteers in group 16 are used as the control group, and are applied with the medical fixation patch prepared in Example 1 of Patent 202111609907.4; After continuous application for 7 days and 30 days, record the dozing situation of the volunteers in each group, and record it as significant effect and insignificant effect. Use the formula: n / 50×100% (n is the number of people with significant effect) to calculate the proportion of people with significant refreshing effect.

[0176] The test results are shown in Table 3 below.

[0177] Table 3

[0178] Group Percentage of significant refreshing effect at 7d (%) Percentage of significant refreshing effect at 30d (%) Example 16 66.7 96.7 Example 17 60.0 93.3 Example 18 50.0 83.3 Example 19 46.7 86.7 Example 20 73.3 100.0 Example 21 70.0 100.0 Example 22 43.3 73.3 Example 23 50.0 80.0 Example 24 43.3 83.3 Example 25 43.3 76.7 Example 26 50.0 86.7 Example 27 73.3 100.0 Example 28 76.7 100.0 Example 29 66.7 96.7 Example 30 60.0 90.0 Control group 46.7 93.3

[0179] As shown in the table, after continuous use of the medical fixation patches of Examples 16 and 17 of the present application for 7 days, the proportion of people with significant effect is more than 60%, and after continuous use for 30 days, the proportion of people with significant effect is more than 90%; Compared with Examples 16 and 14, after using the medical fixation patches of Examples 18 and 19 and Examples 22 - 26 and the control group for 7 days, the proportion of people with significant effect is not higher than 50%, and after using for 30 days, the proportion of people with significant effect also decreases significantly, indicating that the medical fixation patch provided by the present application has a significant refreshing effect and quick results, and can have a significant effect after 7 days of use. Compared with Examples 16 and 17, the proportion of people with significant effect of the medical fixation patches of Examples 20 and 21 after using for 7 days and 30 days has increased, indicating that when the weight ratio of angelica, tsaoko and astragalus membranaceus is in the range of 10:(3 - 4):(1 - 1.4), the medical fixation patch has a better refreshing effect and quick results. The effects of Examples 27 and 28 after 7 days are better than those of Example 16. The presence of tea polyphenols can promote the extraction of active ingredients, thereby improving the drug effect, while the effect of Example 29 after 7 days is lower than that of 16, indicating that the higher the content of total flavonoids and polysaccharides, the better the drug effect is not necessarily true, and the presence of tea polyphenols also has a certain impact on the exertion of the drug effect.

[0180] (3) Warm - heat and damp -ness expelling test

[0181] Select SPF - grade Wistar rats for the test. There are equal numbers of male and female rats, and the body weight is 200±20 g. The test method is as follows:

[0182] (1) Establish a rat model of spleen deficiency with failure of spleen to transform water-dampness and internal dampness syndrome: Feed the rats with 10 - 15 g of cabbage per rat on odd days and lard (1.5 ml / 100 g) on even days, and let them drink water and eat normally. Every day, put the rats into warm water at 38 °C and swim until they are fatigued, with their noses and mouths submerged in the water and their limbs and tails swinging slowly. Stop modeling after 21 days. The rats' apparent manifestations are listlessness and laziness in movement. If the rats' feces continuously show a high-moisture and highly viscous pond mud shape, it is regarded as successful modeling.

[0183] (2) Randomly divide the rats after successful modeling into 17 groups, namely the model control group, Example 16 - 30 groups, and the comparative example group, with 10 rats in each group. Another 10 unmodeled rats are selected as the blank control group. Shave the rat hair at the navel part of all rats, with the shaving area being 3 cm × 3 cm. Then apply the medical fixation patches of the above Example 16 - 30 groups to the rats in Example 16 - 30 groups, apply the medical fixation patch prepared in Example 1 of Patent 202111609907.4 to the comparative example group, apply normal saline to the model control group and the blank control group and fix them with gauze. Apply the patches for 2 h every day and continuously apply for 30 d. After the end, collect the rats' feces and weigh them, which is recorded as the wet weight of the feces. Then dry the feces to a constant weight and weigh them, which is recorded as the dry weight of the feces. Calculate the fecal moisture content, and the formula is: Fecal moisture content = (fecal wet weight - fecal dry weight) / wet weight × 100%.

[0184] The test results are shown in Table 4 below.

[0185] Table 4

[0186]

[0187]

[0188] (Note: Compared with the blank control group, # p < 0.05; compared with the model control group, *p < 0.05)

[0189] Generally, spleen dampness and poor spleen transportation will show symptoms such as physical drowsiness, heaviness, weakness, and easy fatigue. And more moisture in the human body will lead to a larger water content in the feces. Therefore, the fecal moisture content is one of the key indicators of spleen dampness. This application uses the decrease in fecal moisture content to evaluate the effect of expelling dampness. According to the data in the table, after applying the medical fixation patches of Examples 16, 17, 20, 21, 27, and 28 for 30 d, the fecal moisture content decreased significantly, showing a significant difference compared with the model control group, indicating that the medical fixation patches of this application have an obvious effect of warming and expelling dampness.

[0190] Test Example 4

[0191] Referring to the method for testing the peel strength of medical tapes in YY / T 0148-2006, the peel strength of the medical fixation patches prepared in Example 16 and Examples 31-40 was tested; and referring to the above test method, the medical fixation patch was attached to a stainless steel plate and immersed in artificial sweat for 5 min at a temperature of 37 ± 2 °C, and the peel strength after immersion was tested, and the peel strength reduction rate was calculated. The artificial sweat was purchased from Shanghai Xinyu Biotechnology Co., Ltd., with a pH of 4.7; the temperature during the immersion process was 37 ± 2 °C and the time was 24 h.

[0192] The formula for calculating the peel strength reduction rate is: (A - B) / A × 100%; where A represents the initial peel strength and B represents the peel strength after immersion in artificial sweat.

[0193] The test results are shown in Table 5 below.

[0194] Table 5

[0195] Group Initial peel strength (N / cm) Peel strength decline rate (%) Example 16 1.93 9.42 Example 31 1.62 16.37 Example 32 1.84 13.55 Example 33 1.78 14.81 Example 34 1.71 15.78 Example 35 1.80 14.03 Example 36 2.34 4.96 Example 37 2.47 5.18 Example 38 2.50 8.62 Example 39 1.98 8.67 Example 40 1.98 15.20

[0196] According to the records in the table, the medical fixation patch obtained in Example 16 has good adhesiveness, and the peel strength reduction rate after immersion in artificial sweat is 9.42%, showing good sweat resistance. Compared with Example 16, in Example 31, the addition of sepiolite is excessive, resulting in a decrease in the peel strength of the obtained medical fixation patch and an increase in the peel strength reduction rate. This may be because the excessive amount of sepiolite leads to a decrease in the dispersion uniformity in the pressure-sensitive adhesive, thus affecting the peel strength of the pressure-sensitive adhesive. In the places where the relative density of sepiolite is large, the intermolecular force between the molecular chains of the adhesive layer is weak, and the water molecules and the components in the sweat are more likely to break these weak connection points, resulting in a decrease in sweat resistance.

[0197] In Examples 32 and 33, the amount of small-particle-size or large-particle-size sepiolite added is excessive. In Examples 34 and 35, only one particle-size of sepiolite is used, resulting in a decrease in the peel strength and sweat resistance of the obtained medical fixation patch. This may be because the addition of only small-particle-size sepiolite easily causes a decrease in dispersion uniformity, while large-particle-size sepiolite is prone to form stress concentration points in the pressure-sensitive adhesive. Cracks are likely to occur at these stress concentration points, thus reducing the peel strength and being unfavorable for water absorption and transmission in the channels, resulting in a decrease in sweat resistance performance.

[0198] In Examples 36-38, sepiolite is added after being modified with 4-methacrylamidosalicylic acid, which helps to improve the dispersion uniformity of sepiolite, increase the intermolecular force with the pressure-sensitive adhesive molecules, making it not easily damaged during peeling, thus improving the peel strength. It also helps to form a certain void structure, which is more conducive to the transmission of sweat, enabling the sweat to be discharged more effectively and increasing the sweat resistance. However, if the amount of 4-methacrylamidosalicylic acid is excessive, a more compact structure is easily formed between sepiolite and the pressure-sensitive adhesive. Although it has a high peel strength, it is not conducive to the transmission of sweat, and the sweat resistance decreases significantly.

[0199] In Example 40, sepiolite was not added. It had good viscosity but low sweat resistance. Therefore, sepiolite was added to the drug-loading layer. By reasonably matching the two particle size dimensions and proportions of sepiolite, more channels could be formed, which could well achieve water absorption and transmission in the channels, improve the moisture excretion effect, increase the comfort and sweat resistance of the medical fixation patch, avoid falling off after encountering water or sweat, resulting in the inability of the drug to continuously exert its effect, thus affecting the treatment effect and prolonging the treatment cycle, and it would not affect its viscosity. After modifying sepiolite with 4-methylacrylamidosalicylic acid and adding it, by controlling the dosage of 4-methylacrylamidosalicylic acid, not only could the structure of the pressure-sensitive adhesive be changed to form a certain void structure, which was more conducive to the transmission of sweat, enabling the sweat to be discharged more efficiently, thus further enhancing the moisture absorption and sweat excretion performance, but also it was helpful to improve the viscosity of the pressure-sensitive adhesive.

[0200] The above description of the embodiments is for the convenience of those of ordinary skill in the art to understand and use the application. Obviously, those who are familiar with the technology in this field can easily make various modifications to these embodiments and apply the general principles described herein to other embodiments without creative labor. Therefore, this application is not limited to the above embodiments, and all improvements and modifications made by those skilled in the art without departing from the scope of this application according to the disclosure of this application should be within the protection scope of this application.

Claims

1. A Chinese medicine composition, characterized in that: The Chinese medicine composition comprises, by weight: Component I: 30-50 parts of angelica, 10-15 parts of tsaoko, 5-10 parts of astragalus, 60-100 parts of clove oil, 8-12 parts of lemon eucalyptus, and 15-30 parts of sesame oil; Component II: 50-65 parts of wintergreen oil, 5-10 parts of eucalyptus oil, 5-10 parts of litsea cubeba oil, 5-10 parts of camphor oil, 30-50 parts of menthol and 5-10 parts of borneol; Among them, the weight ratio of component I to component II is (1.2-1.5):

1.

2. The Chinese medicine composition according to claim 1, characterized in that: The weight ratio of angelica sinensis to amomum villosum and astragalus membranaceus is 10:(3-4):(1-1.4).

3. The Chinese medicine composition according to claim 1, characterized in that The method for extracting angelica, tsaoko and astragalus comprises the following steps: (1) Crush and mix angelica sinensis, tsaoko and astragalus to obtain dry powder; (2) adding the dry powder into water for extraction, filtering, and obtaining a first extract and medicinal residues; (3) adding the medicinal residue to water, adding a composite enzyme for enzymolysis, boiling and sterilizing after the enzymolysis, and filtering to obtain a second extract; (4) mixing the first extract and the second extract, spray drying, crushing, and sieving to obtain a mixed extract; The complex enzyme is cellulase, hemicellulase and beta-glucosidase in a weight ratio of 10:(2-4):(1-2); the total amount of the complex enzyme is 2-3% of the weight of the medicinal residue.

4. The Chinese medicine composition according to claim 3, characterized in that: In step (2), the water also contains tea polyphenols, and the weight ratio of water to tea polyphenols is (95-98):(2-5).

5. The Chinese medicine composition according to claim 4, characterized in that: When extracting with a mixed solvent of water and tea polyphenols, the extraction temperature is 60-75°C and the extraction time is 3-4h.

6. The method for preparing the Chinese medicine composition according to any one of claims 1 to 5, characterized in that: The steps include: The mixed extract is extracted from angelica, tsaoko and astragalus, and then evenly mixed with clove oil, lemon eucalyptus, sesame oil, wintergreen oil, eucalyptus oil, litsea cubeba oil, camphor oil, menthol and borneol to obtain the product.

7. A medical fixing patch containing a Chinese medicine composition, characterized in that: It includes a drug-carrying layer, a backing layer, and a protective film layer; The drug-carrying layer comprises a pressure-sensitive adhesive, sepiolite, and the Chinese medicine composition according to any one of claims 1 to 5 or the product prepared by the preparation method according to claim 6; The weight ratio of the Chinese medicine composition, the pressure-sensitive adhesive and the sepiolite is 1:(3-9):(0.07-0.1).

8. The medical fixing patch containing the Chinese medicine composition according to claim 7, characterized in that: The sepiolite is a combination of two particle sizes, particle size I is 150-200 meshes, particle size II is 350-400 meshes, and the weight ratio is 1:(2-3).

9. The medical fixing patch containing a Chinese medicine composition according to claim 8, characterized in that: The surface of the sepiolite is also loaded with 5-7% 4-methacrylamide salicylic acid.

10. The method for preparing the medical fixing patch containing the Chinese medicine composition according to any one of claims 7 to 9, characterized in that: The following steps are involved: S1, uniformly mixing the molten pressure-sensitive adhesive, the Chinese medicine composition and the sepiolite, filling with inert gas and pressurizing to obtain a drug-carrying layer mixture; S2. coating the drug-carrying layer mixture on the backing layer, and then compounding it with the protective film layer to obtain a medical fixing patch containing the Chinese medicine composition.

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