Blood cell analyzer

Abstract

A shielding assembly of the hematology analyzer forms a shielding space through enclosure of a bottom plate, a top plate and a first side plate, an impedance detection assembly comprises an electrode connecting piece and a CBC analog circuit board card, the electrode connecting piece is arranged on the first side plate of the shielding assembly, and the CBC analog circuit board card is arranged on the top plate of the shielding assembly. And the CBC analog circuit board card is conducted with the electrode connecting piece through a lead. When impedance detection is carried out, the kit is located in a shielding space formed by the shielding assembly, the electrode connecting piece is electrically connected with an electrode on the kit, and the CBC analog circuit board card is located outside the shielding space, so that interference of an electromagnetic signal generated by the CBC analog circuit board card on an electric pulse signal generated in the electric connection process is reduced, and the accuracy of impedance detection is improved; in addition, the shielding assembly can also shield devices which may generate electromagnetic interference, such as a motor, outside the shielding assembly, so that the anti-interference performance of the hematology analyzer is improved.

Description

Technical Field

[0001] This application relates to the technical field of medical devices, and particularly to a blood cell analyzer. Background Art

[0002] In the field of medical devices, various blood cells in a blood sample can be automatically analyzed by a blood cell analyzer to obtain the component indexes of the blood cells. The existing blood cell analyzer may be provided with an impedance detection component to perform impedance detection on a sample to be tested. When the impedance detection component uses the impedance method to test the sample to be tested, it is necessary to capture the change in the electrical pulse signal of the sample to be tested between the electrode components to characterize some characteristics of the blood cells.

[0003] However, the electrical pulse signal of the sample to be tested is relatively weak and is easily interfered by other factors such as electromagnetism, resulting in a large error in the counting result of the impedance detection component, which is not conducive to improving the accuracy of the blood cell analyzer. Summary of the Invention

[0004] In order to solve the technical problem that the electrical pulse signal is easily interfered in the prior art, this application provides a blood cell analyzer.

[0005] In order to solve the technical problems existing in the prior art, this application provides a blood cell analyzer, including a shielding component, a transfer component, and an impedance detection component. The shielding component includes a bottom plate, a top plate, and a first side plate. The top plate is located above the bottom plate, and the first side plate is located between the bottom plate and the top plate and is respectively connected to the bottom plate and the top plate. The bottom plate, the top plate, and the first side plate are used to enclose a shielding space; the transfer component is used to hold and transfer a reagent kit containing a sample to be tested; the impedance detection component includes an electrode connector and a CBC analog circuit board card. The electrode connector is disposed on the first side plate, and the CBC analog circuit board card is electrically connected to the electrode connector through a wire. The CBC analog circuit board card is located outside the shielding space; when performing impedance detection, the reagent kit is located inside the shielding space, and the electrode connector is electrically connected to the electrode on the reagent kit.

[0006] Optionally, the impedance detection component further includes a first shielding member. A second opening is provided on the first side plate, and the electrode connector is installed on the first side plate through the second opening so that a part of the electrode connector is exposed outside the shielding component. The first shielding member is disposed on the first side plate and is used to cover the part of the electrode connector exposed outside the shielding component.

[0007] Optionally, the transfer assembly includes a guide rail, a moving seat, and at least one second motor. The guide rail is disposed on the bottom plate, the moving seat is slidably connected to the guide rail, the moving seat is used to hold a reagent kit including a sample to be tested, and the moving seat can move along the guide rail within the shielding space formed by the shielding assembly under the drive of the second motor. When moving to the detection position, the electrodes of the reagent kit held by the moving seat are docked with the electrode connection member.

[0008] Optionally, the second motor is located outside the shielding space formed by the shielding assembly.

[0009] Optionally, the blood cell analyzer further includes a liquid transfer assembly. The liquid transfer assembly is disposed on the side of the top plate away from the bottom plate. A pipette tip is stored on the reagent kit. The top plate is provided with a first opening. The liquid transfer assembly includes a first motor and a liquid transfer joint. The liquid transfer joint is connected to the first motor. The first motor is used to drive the liquid transfer joint to move in a first direction so that the liquid transfer joint is docked with the pipette tip of the reagent kit through the first opening.

[0010] Optionally, the electrode connection member includes an electrode bushing, a first electrode, and a second electrode. The first electrode and the second electrode are respectively fixed on the electrode bushing. Wiring holes are provided on the first electrode and the second electrode. The sides of the first electrode and the second electrode away from the wiring holes are located within the shielding assembly so that the transfer assembly moves the reagent kit and the electrodes of the reagent kit are docked with the first electrode and the second electrode.

[0011] Optionally, the blood cell analyzer further includes a fluorescence detection assembly. The top plate is provided with a third opening. The fluorescence detection assembly is installed on the top plate and performs fluorescence detection on the sample to be tested through the third opening. Among them, the housing of the fluorescence detection assembly includes a metal part, and the metal part is grounded to the shielding assembly.

[0012] Optionally, the transfer assembly includes a guide rail and a moving seat. The guide rail is disposed on the bottom plate, the moving seat is slidably connected to the guide rail, and the moving seat is used to carry and move a reagent card. The blood cell analyzer further includes a biochemical detection assembly, and the biochemical detection assembly is used to perform biochemical detection on the sample to be tested on the reagent card. Among them, the biochemical detection assembly includes a biochemical detection circuit board and a second shielding member. The biochemical detection circuit board is disposed on the side of the moving seat away from the reagent card, and the second shielding member is used to cover the biochemical detection circuit board. Or, the detection nodes of the biochemical detection assembly and the impedance detection assembly do not coincide.

[0013] Optionally, the shielding assembly further includes a second side plate. The second side plate is located between the bottom plate and the top plate and is respectively connected to the bottom plate and the top plate. The second side plate is disposed opposite to the first side plate. The second side plate is provided with a fourth opening corresponding to the transfer assembly so that the transfer assembly can move outside the shielding assembly through the fourth opening. The blood cell analyzer further includes a door, and the door is disposed on the second side plate and is used to shield the fourth opening.

[0014] Optionally, the hematology analyzer further includes a negative pressure component. A fifth opening is provided on the first side plate. The negative pressure component is mounted on the first side plate through the fifth opening. The negative pressure component includes a negative pressure connector and a third shielding member. The negative pressure connector is partially exposed outside the shielding component. The third shielding member is used to cover the negative pressure connector exposed outside the shielding component.

[0015] Compared with the prior art, in the hematology analyzer of the present application, the electrode connecting member of the impedance detection component is disposed on the first side plate of the shielding component. The CBC analog circuit board is electrically connected to the electrode connecting member through a wire, and the CBC analog circuit board is located outside the shielding space. When performing impedance detection, the reagent kit is located in the shielding space formed by the shielding component. The electrode connecting member is electrically connected to the electrodes on the reagent kit, and the connection positions between the reagent kit and the electrode connecting member are all located within the shielding component, reducing the interference of devices such as motors that may generate electromagnetic signals outside the shielding component, improving the accuracy of impedance detection, and enhancing the anti-interference performance of the hematology analyzer. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the embodiments. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on these drawings.

[0017] Figure 1 is a schematic structural diagram of the first embodiment of the hematology analyzer provided by the present application;

[0018] Figure 2 is a schematic structural diagram of the second embodiment of the hematology analyzer provided by the present application;

[0019] Figure 3 is a schematic structural diagram of the third embodiment of the hematology analyzer provided by the present application;

[0020] Figure 4 is Figure 1 a schematic structural diagram of the impedance detection component in;

[0021] Figure 5 is Figure 4 a schematic structural diagram of the electrode connecting member in;

[0022] Figure 6 is a schematic structural diagram of an embodiment of the docking of the reagent kit and the electrode connecting member;

[0023] Figure 7 is Figure 2 a schematic structural diagram of an embodiment of the moving seat in;

[0024] Figure 8 is Figure 2 a schematic structural diagram of an embodiment of the negative pressure assembly in

[0025] Figure 9 a schematic structural diagram of the third embodiment of the blood cell analyzer provided by the present application. Specific Embodiments

[0026] The present application will be further described in detail below with reference to the accompanying drawings and embodiments. It should be specifically noted that the following embodiments are only used to illustrate the present application, but do not limit the scope of the present application. Similarly, the following embodiments are only some embodiments of the present application rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present application.

[0027] Reference to "embodiment" herein means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the present application. The phrase appears in various places in the specification and does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment mutually exclusive with other embodiments. Those skilled in the art will explicitly and implicitly understand that the embodiments described herein can be combined with other embodiments.

[0028] In the description of the present application, it should be noted that unless otherwise clearly specified and limited, the terms "installed", "set", "connected", and "coupled" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium. For those of ordinary skill in the art, if there are directional indications (such as up, down, left, right, front, back...) in the embodiments of the present application, the directional indications are only used to explain the relative positional relationship and movement conditions between components in a specific posture (as shown in the drawings). If the specific posture changes, the directional indications will also change accordingly.

[0029] Please refer to Figures 1-3 , Figure 1 a schematic structural diagram of the first embodiment of the blood cell analyzer provided by the present application, Figure 2 a schematic structural diagram of the second embodiment of the blood cell analyzer provided by the present application, Figure 3 a schematic structural diagram of the third embodiment of the blood cell analyzer provided by the present application. As Figures 1-3 shown, an embodiment of the present application provides a blood cell analyzer, which includes a shielding assembly 10, a transfer assembly 20, and an impedance detection assembly 30.

[0030] The shielding component 10 includes a bottom plate 11, a top plate 12, and a first side plate 13. The top plate 12 is located above the bottom plate 11. The first side plate 13 is located between the bottom plate 11 and the top plate 12 and is respectively connected to the bottom plate 11 and the top plate 12. The bottom plate 11, the top plate 12, and the first side plate 13 are used to enclose a shielding space. The transfer component 20 is used to hold and transfer the test kit 211 containing the sample to be tested. The impedance detection component 30 includes an electrode connector 31 and a CBC analog circuit board card 33. The electrode connector 31 is disposed on the first side plate 13. The CBC analog circuit board card 33 is electrically connected to the electrode connector 31 through a wire. The CBC analog circuit board card 33 is located outside the shielding space. When impedance detection is performed, the test kit 211 is located inside the shielding space, and the electrode connector 31 is electrically connected to the electrodes on the test kit 211.

[0031] Specifically, the shielding component 10 may include a bottom plate 11, a top plate 12, a first side plate 13, and a second side plate 14. The bottom plate 11 and the top plate 12 are disposed opposite to each other, and the top plate 12 is located above the bottom plate 11. The first side plate 13 is located between the bottom plate 11 and the top plate 12 and the first side plate 13 is respectively connected to the bottom plate 11 and the top plate 12. The first side plate 13 and the second side plate 14 are disposed opposite to each other. The first side plate 13, the bottom plate 11, and the top plate 12 enclose a shielding space. The position of the shielding space relative to the second side plate 14 forms an opening, so that the test kit 211 can enter and exit the shielding space through the position of the second side plate 14. Among them, the first side plate 13 may be a plate assembled by three side plates. For example, the first side plate 13 may further include a first sub-side plate, a second sub-side plate, and a third sub-side plate. The first sub-side plate is opposite to the second side plate 14. The second sub-side plate is adjacent to the first side plate 13 and the second side plate 14 respectively. The third sub-side plate is opposite to the third side plate 15. The bottom plate 11, the top plate 12, the first side plate 13, and the second side plate 14 enclose to form a shielding space, so that the shielding component 10 can shield devices such as the test kit 211 and the electrode connector 31 located inside the shielding space.

[0032] When impedance detection is performed, the test kit 211 is located inside the shielding space. The electrodes on the test kit 211 are electrically connected to the electrode connector 31. The position where the electrodes of the test kit 211 are electrically connected to the electrode connector 31 is located inside the shielding component 10. Among them, the electrodes of the test kit 211 include a third electrode 213 and a fourth electrode 214. One of the third electrode 213 and the fourth electrode 214 is a positive electrode, and the other is a negative electrode. The electrode connector 31 of the impedance detection component 30 is used to divert an external current or voltage between the third electrode 213 and the fourth electrode 214 to collect the electrical pulse signal of the sample to be tested between the third electrode 213 and the fourth electrode 214, and characterize some characteristics of blood cells according to the change of the electrical pulse signal.

[0033] In an optionally implemented embodiment, the CBC analog circuit board card 33 is integrally connected to the main control board of the blood cell analyzer. The electrode connecting member 31 may be partially located inside the shielding assembly 10 and partially outside the shielding assembly 10 to facilitate the installation of the electrode connecting member 31; alternatively, the electrode connecting member 31 may also be entirely disposed inside the shielding assembly 10 to improve the shielding effect of the shielding assembly 10 on the electrode connecting member 31.

[0034] The transfer assembly 20 may include a guide rail 22 and a moving seat 21. The guide rail 22 is disposed on the bottom plate 11. The moving seat 21 is used to place the test sample to be detected. The test sample may be contained in a reagent kit 211 and / or a reagent card 212. The moving seat 21 is slidably disposed on the guide rail 22, so that the transfer assembly 20 can move the reagent kit 211 to different positions through the moving seat 21. For example, the transfer assembly 20 may include an initial position and several detection positions. The transfer assembly 20 moves the test sample at the initial position to the detection position to be tested by the impedance detection assembly 30 or the fluorescence detection assembly 40.

[0035] In the embodiment of the present application, the blood cell analyzer arranges the electrode connecting member 31 of the impedance detection assembly 30 on the first side plate 13 of the shielding assembly 10. The CBC analog circuit board card 33 is electrically connected to the electrode connecting member through a wire. The CBC analog circuit board card 33 is located outside the shielding space. Since during impedance detection, the reagent kit 211 is located inside the shielding space, when the electrode connecting member 31 is electrically connected to the electrode on the reagent kit 211, the connection positions of the reagent kit 211 and the electrode connecting member 211 are both inside the shielding assembly 10, reducing the interference of devices such as motors that may generate electromagnetic signals outside the shielding assembly 10, improving the accuracy of impedance detection, and improving the anti-interference performance of the blood cell analyzer.

[0036] In one embodiment, the blood cell analyzer further includes a liquid transfer assembly 60. The liquid transfer assembly 60 is disposed on the side of the top plate 12 away from the bottom plate 11. A pipette tip 63 is stored on the reagent kit 211. The top plate 12 is provided with a first opening. The liquid transfer assembly 60 includes a first motor 61 and a liquid transfer joint 62. The liquid transfer joint 62 is connected to the first motor 61. The first motor 61 is used to drive the liquid transfer joint 62 to move in a first direction, so that the liquid transfer joint 62 is docked with the pipette tip 63 of the reagent kit 211 through the first opening.

[0037] Specifically, the hematology analyzer in this embodiment is a POCT hematology analyzer, which is used to achieve blood cell testing through the cooperation of the test kit 211 and / or the reagent card 212. It can be understood that the above test kit 211 is a test tool that stores the sample to be tested, reagents, and the pipette tip 63. Moreover, the test kit 211 can also be used as a place for impedance detection to assist in the testing. The pipetting assembly 60 in this embodiment is used to insert the pipette tip 63 on the test kit 211, mix the reagents and the sample to be tested in the test kit 211, and prepare a sample solution suitable for impedance detection, so that the impedance detection assembly 30 can perform impedance detection on the sample solution in the test kit 211.

[0038] The pipetting assembly 60 is disposed adjacent to the fluorescence detection assembly 40. The pipetting assembly 60 is used to insert the pipette tip 63 of the test kit 211 and complete the sample transfer operation through the pipette tip 63. A first opening is formed in the top plate 12. The pipetting assembly 60 includes a first motor 61 and a pipetting joint 62. The pipetting joint 62 is used to sleeved the pipette tip 63 under the action of an external force, and the first motor 61 is used to provide a driving force for the pipetting joint 62 to move the pipetting joint 62 in the first direction.

[0039] Wherein, the first direction is parallel to the direction of gravity. The pipetting joint 62 may include an initial position and a plugging position. When the pipetting assembly 60 does not need to perform pipetting operation, the pipetting joint 62 is located at the initial position and above the top plate 12; when the test kit 211 moves below the pipetting joint 62 and the pipette tip 63 corresponds to the pipetting joint 62, the first motor 61 provides a driving force and drives the moving joint to move downward in the first direction and enter the shielding assembly 10 through the first opening. The pipetting joint 62 docks with the pipette tip 63 on the test kit 211 under the action of the driving force to realize the connection and insertion of the pipette tip 63. In an alternative embodiment, the first motor 61 may be, but is not limited to, a lead screw motor.

[0040] In this embodiment, the hematology analyzer arranges the pipetting assembly 60 on the top plate 12, and the pipetting joint 62 enters the shielding assembly 10 through the first opening on the top plate 12 under the drive of the first motor 61 to insert the pipette tip 63; since the first motor 61 is arranged on the side of the top plate 12 away from the bottom plate 11, the shielding assembly 10 can shield the electromagnetic signals that the first motor 61 may generate, so as to reduce the electromagnetic interference received by the impedance detection assembly 30 and improve the accuracy of impedance detection.

[0041] In one embodiment, please refer to Figures 4-6 , Figure 4 is Figure 1 the schematic structural diagram of the impedance detection assembly in Figure 5 is Figure 4 the schematic structural diagram of the electrode connecting piece in Figure 6It is a schematic structural diagram of an embodiment where the kit is docked with the electrode connector. As Figures 4-6 shown, the impedance detection component 30 further includes a first shielding member 32. A second opening is provided on the first side plate 13. The electrode connector 31 is installed on the first side plate 13 through the second opening, so that a part of the electrode connector 31 is exposed outside the shielding component 10. The first shielding member 32 is arranged on the first side plate 31, and the first shielding member 32 is used to cover the part of the electrode connector 31 exposed outside the shielding component 10.

[0042] Specifically, the impedance detection component 30 further includes a first shielding member 32. The electrode connector 31 can be installed on the first side plate 13 through the second opening. A part of the electrode connector 31 is located inside the shielding component 10 and another part is exposed outside the shielding component 10 (the side of the first side plate 13 away from the transfer component 20), so that a part of the electrode connector 31 is exposed outside the shielding component 10, facilitating the user to install the electrode connector 31 at the position of the second opening when assembling the hematology analyzer. The first shielding member 32 is used to shield the exposed electrodes of the electrode connector 31 and the connected wires.

[0043] When the impedance detection component 30 is used to perform impedance detection on the test sample of the kit 211, an impedance detection position can be set on the transfer component 20. After the transfer component 20 travels a preset step length from the initial position, it drives the kit 211 to the impedance detection position. The electrodes on the kit 211 are in contact with the electrodes of the electrode connector 31 located inside the shielding component 10, so that the electrode detection component provides a constant detection current for the kit 211. Under the detection current, the test sample in the kit 211 flows through the impedance detection cell, and individual blood cells of the test sample pass through the microporous component in the impedance detection cell and generate electrical pulse signals. The impedance detection component 30 is further used to collect the electrical pulse signals of the test sample and characterize certain characteristics of the blood cells according to the changes in the electrical pulse signals, realizing the impedance detection of the test sample.

[0044] In the embodiment of the present application, the shielding component 10 of the hematology analyzer forms a cabin to wrap the internal transfer component 20 and impedance detection component 30. Moreover, the first shielding member 32 is arranged on the electrode connector 31 and covers the part of the electrode connector 31 exposed outside the shielding component 10, so as to increase the electromagnetic shielding range of the impedance detection mechanism, further reduce the interference of electromagnetic signals on the kit 211 and the electrode connector 31, reduce the electromagnetic interference during impedance detection, and improve the accuracy of impedance detection.

[0045] Optionally, the electrode connection member 31 includes an electrode bushing 311, a first electrode 312, and a second electrode 313. The first electrode 312 and the second electrode 313 are respectively fixed on the electrode bushing 311. Wiring holes 314 are formed in the first electrode 312 and the second electrode 313. The sides of the first electrode 312 and the second electrode 313 away from the wiring holes 314 are located within the shielding assembly 10, so that the transfer assembly 20 moves the test kit 211 and docks the electrodes of the test kit 211 with the first electrode 312 and the second electrode 313.

[0046] Specifically, the first electrode 312 and the second electrode 313 are inserted into the electrode bushing 311. The electrode bushing 311 is used to maintain the stability of the first electrode 312 and the second electrode 313, so that the first electrode 312 and the second electrode 313 are maintained at positions with a preset height. Wiring holes 314 are formed in the first electrode 312 and the second electrode 313. The sides of the first electrode 312 and the second electrode 313 close to the wiring holes 314 are exposed outside the shielding assembly 10. The first electrode 312 and the second electrode 313 are connected to an external power supply line through the wiring holes 314, so that after the electrodes of the test kit 211 are docked with the first electrode 312 and the second electrode 313, the test kit 211 is electrically conducted. Among them, one of the first electrode 312 and the second electrode 313 can be a positive electrode, and the other can be a negative electrode.

[0047] Further, the first electrode 312 and the second electrode 313 are respectively sleeved with first elastic members 315. The first elastic members 315 are used to play a buffering role to slow down the impact force generated when the transfer assembly 20 pushes the electrodes of the test kit 211 to abut against the first electrode 312 and the second electrode 313, and improve the stability of the electrode connection member 31.

[0048] In one embodiment, the blood cell analyzer further includes a fluorescence detection assembly 40. The top plate 12 is provided with a third opening. The fluorescence detection assembly 40 is installed on the top plate 12 and performs fluorescence detection on the sample to be tested through the third opening.

[0049] Specifically, a third opening is provided on the top plate 12. The fluorescence detection assembly 40 is located on one side of the liquid transfer assembly 60 and is installed on the top plate 12. The fluorescence detection assembly 40 may include a light generator and a light receiver. The light generator is used to emit a detection beam through the third opening so that the detection beam irradiates the sample to be tested. The sample to be tested emits fluorescence under the action of the detection beam. The light receiver is used to receive the excitation light of the sample to be tested and characterize the blood cell characteristics of the sample to be tested according to the intensity of the excitation light.

[0050] Among them, the housing of the fluorescence detection component 40 is a metal part, and the metal part and the shielding component 10 are grounded. Specifically, the housing of the fluorescence detection component 40 can be composed of a metal part, or the housing of the fluorescence detection component 40 can also include a plastic part, and a metal part is sleeved outside the plastic part. By grounding the metal part and the shielding component 10, the metal part of the fluorescence detection component 40 can be used to shield the electromagnetic signals generated during the fluorescence detection process of the fluorescence detection component 40, reducing the electromagnetic interference in impedance detection.

[0051] In this embodiment, the hematology analyzer arranges the fluorescence detection component 40 on the top plate 12. The fluorescence detection component 40 emits a detection beam through the third opening on the top plate 12 into the shielding component 10 for fluorescence detection, so that the shielding component 10 can shield the fluorescence detection component 40; since the shielding component 10 forms a cabin to shield the internal devices, the shielding component 10 can also play a role in shading, so as to perform fluorescence detection in an environment with low brightness. The image contrast of fluorescence detection is higher in the dark environment, further improving the accuracy of fluorescence detection.

[0052] Optionally, the transfer component 20 can simultaneously receive the reagent kit 211 for impedance detection and the first reagent card 212 for fluorescence detection, and the transfer component 20 synchronously drives the reagent kit 211 and the first reagent card 212 to move along the first direction. The transfer component 20 includes an impedance detection position and a fluorescence detection position. The transfer component 20 is used to move the reagent kit 211 to the impedance detection position so that the impedance detection component 30 performs an impedance detection operation on the reagent kit 211 at the impedance detection position; the transfer component 20 is also used to move the first reagent card 212 to the fluorescence detection position so that the fluorescence detection component 40 performs fluorescence detection on the first reagent card 212 at the fluorescence detection position.

[0053] In one embodiment, the detection nodes of the fluorescence detection component 40 and the impedance detection component 30 do not coincide.

[0054] Specifically, the fluorescence detection component 40 and the impedance detection component 30 respectively detect the test sample in the reagent kit 211. For example, the fluorescence detection component 40 first performs fluorescence detection on the test sample in the reagent kit 211, and then the impedance detection component 30 performs impedance detection on the test sample in the reagent kit 211, or the impedance detection component 30 first performs impedance detection on the test sample in the reagent kit 211, and then the fluorescence detection component 40 performs fluorescence detection on the test sample in the reagent kit 211. Since the electrical pulse signal is relatively sensitive and weak when the impedance detection component 30 performs impedance detection, and the detection nodes of the fluorescence detection component 40 and the impedance detection component 30 do not coincide, the interference degree of the electromagnetic signal of the fluorescence detection component 40 on the impedance detection component 30 during fluorescence detection can be reduced, improving the accuracy of impedance detection.

[0055] In an optional implementation, when the user uses a hematology analyzer, the test samples to be detected are respectively added to the sample storage positions of the reagent kit 211 and the first reagent card 212, and the reagent kit 211 and the first reagent card 212 are placed in the receiving positions of the hematology analyzer, so that the transfer assembly 20 can receive the reagent kit 211 and the first reagent card 212 simultaneously. The transfer assembly 20 first moves the reagent kit 211 to the pipetting assembly 60, so that the pipetting assembly 60 transfers and prepares the sample between multiple reagent pools and the detection pool of the reagent kit 211. After the sample solution preparation is completed, the transfer assembly 20 moves the reagent kit 211 to the impedance detection position, so that the electrodes of the reagent kit 211 are docked with the electrode connector 31 to achieve impedance detection. During the impedance detection of the reagent kit 211, the test samples on the first reagent card 212 are incubated simultaneously to utilize the time of impedance detection for sample incubation. After the impedance detection of the reagent kit 211 is completed, the transfer assembly 20 moves the incubated first reagent card 212 to the fluorescence detection position, and the fluorescence detection assembly 40 performs fluorescence detection on the first reagent card 212, saving the waiting time for incubation and improving the detection speed.

[0056] In one embodiment, the transfer assembly 20 includes a guide rail 22 and a moving seat 21. The guide rail 22 is disposed on the bottom plate 11, and the moving seat 21 is slidably connected to the guide rail 22. The moving seat 21 is used to carry and move the reagent card 212 along. The hematology analyzer further includes a biochemical detection assembly 50, and the biochemical detection assembly 50 is disposed on the moving seat 21 and is used to perform biochemical detection on the test samples.

[0057] Specifically, the transfer assembly 20 includes a moving seat 21 and a guide rail 22. The guide rail 22 is used to guide the moving seat 21 to move along a preset first direction. The moving seat 21 is used to receive the reagent card 212, and the test samples are added to the reagent card 212, and the test samples react with the reagents in the reagent card 212. Among them, the hematology analyzer of this embodiment is further provided with a biochemical detection assembly 50, and the biochemical detection assembly 50 is used to test enzymes, proteins, electrolytes, trace elements, etc. in the blood sample, so that the hematology analyzer of this embodiment can perform tests on multiple detection items and has a wide range of uses.

[0058] The biochemical detection assembly 50 is disposed on the moving seat 21 and is used to perform biochemical detection on the test samples in the reagent card 212. For example, a bracket can be disposed on the moving seat 21, and the biochemical detection assembly 50 can be disposed on the bracket and above the reagent card 212, so that the biochemical detection assembly 50 can perform biochemical detection on the reagent card 212. Or, the biochemical detection assembly 50 can be disposed on the side of the moving seat 21 away from the reagent card 212, that is, the biochemical detection assembly 50 is disposed on the back of the reagent card 212, and the user can adjust according to actual needs, and no specific limitation is made here.

[0059] Optionally, adjacent first and second placement positions are provided on the movable seat 21. The first placement position is for placing the reagent kit 211, and the second placement position is for placing the reagent card 212. The impedance detection component 30 is used to perform impedance detection on the test sample in the reagent kit 211, and the fluorescence detection component 40 or the biochemical detection component 50 is used to perform optical detection on the test sample in the reagent card 212.

[0060] Specifically, the first and second placement positions can be of a groove design, enabling the reagent kit 211 and the reagent card 212 to be placed in corresponding positions. The transfer component 20 can include a sampling position. When the movable seat 21 is at the sampling position, a part of the movable seat 21 is exposed outside the shielding component 10, allowing the user to place the reagent kit 211 and the reagent card 212 side by side on the movable seat 21. After sampling is completed, the transfer component 20 is used to control the movable seat 21 to move along the guide rail 22 to the initial position. After the movable seat 21 travels a preset step length from the initial position, the reagent kit 211 is moved below the pipetting component 60 for the pipette tip 63 to be inserted, and sample preparation is carried out through the pipette tip 63. Among them, the reagent kit 211 can include a detection pool and multiple reagent pools. The pipetting component 60 prepares a sample solution to be detected by mixing the reagents in the reagent pools with the test sample and adds the sample solution to the detection pool. The movable seat 21 continues to travel and drives the reagent kit 211 to the impedance detection position, where the electrodes on the reagent kit 211 are in contact with the electrodes of the electrode connection member 31 to perform impedance detection on the sample solution in the detection pool.

[0061] In an optional embodiment, the reagent card 212 in the second placement position includes a first reagent card 212 and a second reagent card 212, and the applicable detection types of the first reagent card 212 and the second reagent card 212 are different. After impedance detection is completed, the movable seat 21 moves the first reagent card 212 from the impedance detection position to the fluorescence detection position, which is located below the fluorescence detection component 40, so that the fluorescence detection component 40 performs a fluorescence test on the test sample on the first reagent card 212; or, the biochemical detection component 50 directly performs a biochemical detection on the test sample on the second reagent card 212.

[0062] In this embodiment, the movable seat 21 of the blood cell analyzer can hold both the reagent kit 211 and the reagent card 212 at the same time, and the second placement position is suitable for the reagent card 212 of the fluorescence detection component 40 and the biochemical detection component 50, enabling both the first reagent card 212 and the second reagent card 212 to be placed on the movable seat 21. There is no need to set multiple placement positions, reducing the volume occupied by the movable seat 21 and making the structure of the blood cell analyzer more compact.

[0063] Optionally, please refer to Figure 7 , Figure 7 is Figure 2Schematic structural diagram of an embodiment of the middle moving seat. As Figure 7 shown, the biochemical detection component 50 includes a biochemical detection circuit board (not shown in the figure) and a second shielding member 51. The biochemical detection circuit board is disposed on the side of the moving seat 21 facing away from the reagent card 212, and the second shielding member 51 is used to cover the biochemical detection circuit board.

[0064] Specifically, the biochemical detection circuit board is located on the side of the moving seat 21 facing away from the reagent card 212 and is correspondingly disposed with the second placement position. The biochemical detection circuit board may include a heating film, and the heating film is used to heat the reagent card 212 during a complete blood count (CBC) by a hematology analyzer. Among them, the main control board of the hematology analyzer can control the heating of the heating film through pulse width modulation (PWM). During the heating control process, electromagnetic signals will be generated, which will interfere with the impedance detection. Therefore, in this embodiment, a second shielding member 51 is provided at the position of the biochemical detection circuit board to cover the biochemical detection circuit board. The second shielding member 51 is used to shield the electromagnetic signals generated during the heating process of the biochemical detection circuit board, so as to reduce the interference degree of the electromagnetic signals on the impedance detection component 30 and improve the accuracy of the impedance detection.

[0065] Among them, the biochemical detection circuit board may be, but is not limited to, a detection circuit provided on a printed circuit board (PCB) or a flexible circuit board. The biochemical detection component 50 may also be provided with a signal acquisition lamp, and the signal acquisition lamp is used to acquire the biochemical information of the sample to be tested on the reagent card 212 to obtain the biochemical detection result. The biochemical detection circuit board of this embodiment is disposed on the side of the moving seat 21 facing away from the reagent card 212, that is, on the back of the reagent card 212. Therefore, the reagent card 212 can be directly subjected to biochemical detection on the moving seat 21 without setting other detection positions, and the structure of the hematology analyzer is more compact.

[0066] Optionally, the detection nodes of the biochemical detection component 50 and the impedance detection component 30 do not coincide.

[0067] Specifically, the biochemical detection component 50 and the impedance detection component 30 perform detections separately. For example, the impedance detection component 30 first detects the sample to be tested in the test kit 211, and then the biochemical detection component 50 detects the sample to be tested in the second reagent card 212; or, the biochemical detection component 50 first detects the sample to be tested in the second reagent card 212, and then the impedance detection component 30 detects the sample to be tested in the test kit 211. Since the electrical pulse signal is relatively sensitive and weak during the impedance detection by the impedance detection component 30, and the detection nodes of the biochemical detection component 50 and the impedance detection component 30 do not coincide, the electromagnetic signal of the biochemical detection component 50 can be reduced from interfering with the impedance detection component 30, thereby improving the accuracy of impedance detection.

[0068] In one embodiment, please refer to Figure 8 , Figure 8 is Figure 2 a schematic structural diagram of an embodiment of the negative pressure component in Figure 8 As shown, the test kit 211 is further provided with a negative pressure chamber, the hematology analyzer further includes a negative pressure component 70, a fifth opening is provided on the first side plate, and the negative pressure component is installed on the first side plate through the fifth opening.

[0069] Specifically, the negative pressure component 70 includes a negative pressure connector 71, a seal 72, and a third shielding member (not shown in the figure). The negative pressure connector 71 is provided with a negative pressure air flow channel. The seal 72 is sleeved on one end of the negative pressure connector 71 to close the negative pressure air flow channel. A part of the negative pressure connector 71 is exposed outside the shielding component 10. The third shielding member is used to cover the negative pressure connector 71 exposed outside the shielding component 10, so that the positions where the test kit 211 is connected to the electrode connector 31 and the negative pressure component 70 are covered by the shielding component 10 and the corresponding shielding members, reducing the electromagnetic interference of impedance detection and improving the anti-interference performance of the hematology analyzer.

[0070] A fixing block and a second elastic member 73 are provided on the side of the negative pressure connector 71 away from the seal 72. Among them, the negative pressure connector 71 is disposed on the first side plate 13 and adjacent to the electrode connector 31. When the transfer component 20 moves the test kit 211 and docks the electrodes of the test kit 211 with the electrode connector 31, under the driving force of the transfer component 20, the negative pressure chamber of the test kit 211 abuts against the seal 72, and the test kit 211 presses the seal 72 under the driving force, causing the second elastic member 73 to be in a compressed state. The fixing member is used to switch the closed state of the seal 72 to communicate the negative pressure air flow channel with the negative pressure chamber. The negative pressure component 70 is used to provide a negative pressure state for the test kit 211, so that the sample solution in the detection pool of the test kit 211 flows along a preset direction under the negative pressure, realizing impedance detection.

[0071] In one embodiment, the transfer assembly 20 includes a guide rail 22, a moving seat 21, and at least one second motor 23. The guide rail 22 is disposed on the bottom plate 11. The moving seat 21 is slidably connected to the guide rail 22. The moving seat 21 is used to hold a reagent kit 211 including a sample to be tested. The moving seat 21 can move along the guide rail 22 within the shielding space formed by the shielding assembly 10 under the drive of the second motor 23. When moving to the detection position, the electrodes of the reagent kit 211 held by the moving seat 21 are docked with the electrode connector 31.

[0072] Specifically, the number of the second motors 23 is related to the movement path of the transfer assembly 20. When the transfer assembly 20 is used to move the reagent kit 211 in a two-dimensional space, the number of the second motors 23 can be two; when the transfer assembly 20 is used to move the reagent kit 211 in a three-dimensional space, the number of the second motors 23 can be three. The user can adjust the movement path and the number of motors according to actual needs, and no specific limitation is made here.

[0073] In an alternative embodiment, the transfer assembly 20 drives the reagent kit 211 to move along a first direction through one second motor 23, that is, the moving seat 21 performs a linear motion along the first direction of the guide rail 22. At this time, the second motor 23 is used to drive the moving seat 21 to move between different positions on the guide rail 22 to assist in completing the following steps of the hematology analyzer: driving the movement of the reagent kit 211 and / or the reagent card 212; driving the reagent kit 211 to move along the first direction so that multiple reagent pools, detection pools, and sample placement positions of the reagent kit 211 are respectively located below the pipetting assembly 60, so that the pipetting assembly 60 transfers and prepares samples for the reagent kit 211 through the pipette tip 63; driving the reagent kit 211 to move to the detection position along the first direction so that the electrodes of the reagent kit 211 are docked with the electrode connector 31, and the negative pressure chamber of the reagent kit 211 is docked with the negative pressure assembly 70. In an alternative embodiment, the hematology analyzer further includes a fluorescence detection assembly 40, and the second motor 23 is further used to drive the reagent card 212 to move to the fluorescence detection position so that the fluorescence detection assembly 40 performs fluorescence detection on the sample to be tested on the reagent card 212.

[0074] In this embodiment, the moving seat 21 of the transfer assembly 20 drives the reagent kit 211 to move along the guide rail 22 and realizes operations at multiple positions of the reagent kit 211, so that processes such as sample transfer operation, incubation, and detection of the reagent kit 211 by the hematology analyzer are all within the shielding space of the shielding assembly 10. The movement of the reagent kit 211 is smooth, and the degree of electromagnetic interference on the impedance detection process of the reagent kit 211 is low. Moreover, the position of the shielding assembly 10 does not need to be moved, and the shielding assembly 10 can also be used as a support to support other components such as the transfer assembly 20 and the impedance detection assembly 30. The hematology analyzer of this embodiment has a compact structure and smooth operation, and does not need to be provided with other motor components for driving, which is beneficial to reducing the volume of the hematology analyzer.

[0075] Optionally, the second motor 23 is located outside the shielding space formed by the shielding assembly 10.

[0076] Specifically, during the process that the second motor 23 drives the moving seat 21 to move the test kit 211 to the detection position, the second motor 23 needs to provide continuous driving force for the moving seat 21 and keep the test kit 211 in a state of being docked with the electrode connection member 31. At this time, since a magnetic field will be generated during the operation of the second motor 23, the electromagnetic signal generated by the second motor 23 will interfere with the electrical pulse signal of the impedance detection assembly 30. Therefore, in this embodiment, the second motor 23 is arranged outside the shielding space, so that the shielding assembly 10 can shield the electromagnetic signal that the second motor 23 may generate, reduce the interference of the impedance detection assembly 30; and does not affect the driving process of the second motor 23 on the moving seat 21, and the moving process of the test kit 211 is smooth.

[0077] Furthermore, the second motor 23 is arranged on the first side plate 13. Specifically, the second motor 23 is arranged on the side of the first side plate 13 away from the second side plate 14, which is convenient for users to assemble the second motor 23, and the first side plate 13 can shield the electromagnetic signal that the second motor 23 may generate, reduce the interference of the impedance detection assembly 30.

[0078] In one embodiment, please refer to Figure 9 , Figure 9 is a schematic structural diagram of the third embodiment of the blood cell analyzer provided by the present application. As Figure 9 shown, the shielding assembly 10 further includes a second side plate 14. The second side plate 14 is located between the bottom plate 11 and the top plate 12 and is respectively connected to the bottom plate 11 and the top plate 12. The second side plate 14 is arranged opposite to the first side plate 13. A fourth opening corresponding to the transfer assembly 20 is provided on the second side plate 14, so that the transfer assembly 20 can move outside the shielding assembly 10 through the fourth opening; the blood cell analyzer further includes a chamber door 80, and the chamber door 80 is arranged on the second side plate 14, and the chamber door 80 is used to shield the fourth opening.

[0079] Specifically, the second side plate 14 of the shielding assembly 10 is arranged opposite to the first side plate 13, and the second side plate 14 and the first side plate 13 are arranged along the first direction. A fourth opening is provided on the second side plate 14, and the area of the fourth opening corresponds to the moving seat 21 of the transfer assembly 20. The blood cell analyzer is also provided with a chamber door 80. The chamber door 80 corresponds to the fourth opening and is arranged on the second side plate 14, and the chamber door 80 is used to shield the fourth opening. In an optional implementation manner, a rotating shaft is provided on the second side plate 14, and the chamber door 80 is rotatably connected to the rotating shaft, so that the chamber door 80 can be opened and closed rotatably through the rotating shaft.

[0080] In this embodiment, when the hematology analyzer needs to perform sample injection, the movable seat 21 of the transfer assembly 20 can be moved outside the shielding assembly 10 through the fourth opening by rotating and opening the chamber door 80, so as to facilitate placing the reagent kit 211 and / or the reagent card 212 on the movable seat 21. After sample injection is completed, by rotating and closing the chamber door 80, the shielding assembly 10 forms a chamber to wrap the internal transfer assembly 20 and the impedance detection assembly 30, so as to shield the electromagnetic interference of the impedance detection assembly 30 and improve the accuracy of impedance detection.

[0081] The above are only the embodiments of the present application, and do not limit the patent scope of the present application accordingly. Any equivalent structure or equivalent process transformation made by using the content of the specification and drawings of the present application, or directly or indirectly applied in other related technical fields, shall be equally included in the patent protection scope of the present application.

Claims

1. A blood cell analyzer, characterized in that, Comprising: A shielding component, including a bottom plate, a top plate and a first side plate. The top plate is located above the bottom plate, and the first side plate is located between the bottom plate and the top plate and is connected to the bottom plate and the top plate. The bottom plate, the top plate and the first side plate are used to enclose a shielding space; A transfer component for containing and transferring a reagent kit containing a sample to be tested; An impedance detection component, including an electrode connection part and a CBC analog circuit board card. The electrode connection part is arranged on the first side plate, and the CBC analog circuit board card is electrically connected to the electrode connection part through a wire. The CBC analog circuit board card is located outside the shielding space; When impedance detection is carried out, the reagent kit is located inside the shielding space, and the electrode connection part is electrically connected to the electrode on the reagent kit.

2. The hematology analyzer according to claim 1, wherein, The impedance detection component further includes a first shielding part. A second opening is provided on the first side plate, and the electrode connection part is installed on the first side plate through the second opening so that a part of the electrode connection part is exposed outside the shielding component. The first shielding part is arranged on the first side plate and is used to cover the part of the electrode connection part exposed outside the shielding component.

3. The hematology analyzer according to claim 1, characterized in that The transfer component includes a guide rail, a moving seat and at least one second motor. The guide rail is arranged on the bottom plate, and the moving seat is slidably connected to the guide rail. The moving seat is used to contain the reagent kit including the sample to be tested. The moving seat can move along the guide rail inside the shielding space formed by the shielding component under the drive of the second motor, and when moving to the detection position, the electrode of the reagent kit contained in the moving seat is docked with the electrode connection part.

4. The hematology analyzer according to claim 3, wherein The second motor is located outside the shielding space formed by the shielding component.

5. The blood cell analyzer according to claim 1 or 3, characterized in that, The hematology analyzer further includes a pipetting component. The pipetting component is arranged on the side of the top plate away from the bottom plate. A pipette tip is stored on the reagent kit. The top plate is provided with a first opening. The pipetting component includes a first motor and a pipetting joint. The pipetting joint is connected to the first motor, and the first motor is used to drive the pipetting joint to move in a first direction so that the pipetting joint is docked with the pipette tip of the reagent kit through the first opening.

6. The hematology analyzer according to claim 5, characterized in that, The electrode connection part includes an electrode bushing, a first electrode and a second electrode. The first electrode and the second electrode are respectively fixed on the electrode bushing. Wiring holes are provided on the first electrode and the second electrode. The sides of the first electrode and the second electrode away from the wiring holes are located inside the shielding component so that the transfer component moves the reagent kit and the electrode of the reagent kit is docked with the first electrode and the second electrode.

7. The hematology analyzer according to claim 6, characterized in that, The hematology analyzer further includes a fluorescence detection component. The top plate is provided with a third opening. The fluorescence detection component is installed on the top plate and performs fluorescence detection on the sample to be tested through the third opening; Wherein, the housing of the fluorescence detection component includes a metal part, and the metal part is grounded with the shielding component.

8. The hematology analyzer according to claim 1, wherein The transfer assembly includes a guide rail and a moving seat, wherein the guide rail is arranged on the bottom plate, the moving seat is slidably connected to the guide rail, and the moving seat is used to carry and move the reagent card. The blood cell analyzer also includes a biochemical detection assembly, and the biochemical detection assembly is used to perform biochemical detection on the sample to be tested on the reagent card; Among them, the biochemical detection component includes a biochemical detection circuit board and a second shielding component, the biochemical detection circuit board is arranged on the side of the movable seat away from the reagent card, and the second shielding component is used to cover the biochemical detection circuit board; or, the detection nodes of the biochemical detection component and the impedance detection component do not overlap.

9. The hematology analyzer according to claim 1, wherein, The shielding assembly also includes a second side plate, which is located between the bottom plate and the top plate and is connected to the bottom plate and the top plate respectively. The second side plate is arranged opposite to the first side plate, and a fourth opening corresponding to the transfer assembly is provided on the second side plate, so that the transfer assembly can be moved outside the shielding assembly through the fourth opening. The blood cell analyzer also includes a compartment door, which is arranged on the second side plate, and is used to shield the fourth opening.

10. The hematology analyzer according to claim 1, wherein, The blood cell analyzer also includes a negative pressure component. A fifth opening is provided on the first side panel. The negative pressure component is installed on the first side panel through the fifth opening. The negative pressure component includes a negative pressure connector and a third shielding component. The negative pressure connector is partially exposed outside the shielding component. The third shielding component is used to cover the negative pressure connector exposed from the shielding component.

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