Sample analyzer and magnetic separation mechanism
By using different design magnetic components in the magnetic separation mechanism of the sample analyzer, the problem of taking into account both the magnetic suction position and the liquid suction level is solved, and the rapid adsorption and stability are combined, and the accuracy of the measurement results is improved.
Patent Information
- Application Number
- CN202411303033.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Priority Date
- 2023-12-29
- Filing Date
- 2024-09-18
- Publication Date
- 2025-07-01
AI Technical Summary
The magnetic separation mechanism of the existing sample analyzer is difficult to take into account the adsorption speed of the magnetic suction position and the adsorption stability at the liquid suction position, which affects the accuracy of the measurement results.
The magnetic components that adopt different designs of the first magnetic suction position and the first liquid absorbing level are respectively used for rapid adsorption and stabilization of magnetic beads. By providing pairs and spaced first magnetic devices at the first magnetic suction position and a single second magnetic device at the first liquid absorbing level, the combination of rapid adsorption and stable adsorption is achieved.
The adsorption speed of the magnetic absorption position and the adsorption stability of the liquid absorption level are improved, the rapid adsorption and stability of the magnetic beads and target substances are ensured, and the accuracy of the measurement results are improved.
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Figure CN120233100A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of in vitro diagnostic devices, and particularly to a sample analyzer and a magnetic separation mechanism of the sample analyzer. Background Art
[0002] A sample analyzer provided by the related art has a measurement process for a sample that includes: first, performing a magnetic separation operation on the liquid after incubation of the sample and a reagent containing magnetic beads in a reaction vessel through a magnetic separation mechanism, and then measuring a test liquid formed at least from the liquid after the magnetic separation operation in the reaction vessel through a measurement mechanism to obtain measurement information. Among them, the magnetic separation mechanism is provided with a magnetic adsorption position and a liquid suction position. The magnetic adsorption position is used for a magnet to magnetically adsorb the liquid in the reaction vessel to form a magnetic bead cluster adsorbed on the inner wall of the reaction vessel, and the liquid suction position is used for a liquid suction component to suck away the liquid in the reaction vessel except the magnetic bead cluster. In order to ensure that the magnetic bead cluster can remain adsorbed on the inner wall of the reaction vessel during the liquid suction process, a magnet is also required at the liquid suction position to adsorb the magnetic bead cluster.
[0003] In the related art, the magnets at the magnetic adsorption position and the liquid suction position adopt the same setting scheme, that is, the orientation of the magnet relative to the working position and the number of magnets are the same. For example, a single magnet is provided on one side of the magnetic adsorption position, and a single magnet is also provided on one side of the liquid suction position. However, since the design requirements of the magnets at the magnetic adsorption position and the liquid suction position are not very the same, the magnet at the magnetic adsorption position needs to adsorb the magnetic beads and the target substances bound to the magnetic beads in the reaction vessel to a designated position as quickly as possible to form a magnetic bead cluster on the inner wall of the reaction vessel, while the magnet at the liquid suction position needs to stably adsorb the magnetic beads and the target substances bound to the magnetic beads on the inner wall of the reaction vessel. That is, the design of the magnet at the magnetic adsorption position focuses more on the adsorption speed, and the design of the magnet at the liquid suction position focuses more on the adsorption stability. Therefore, if the same setting scheme is used for the magnets at the magnetic adsorption position and the liquid suction position, either the adsorption speed at the magnetic adsorption position will decrease, or the adsorption stability at the liquid suction position will decrease, or the magnets at the magnetic adsorption position and the liquid suction position will be designed more complexly and the cost will be relatively high, making it difficult to balance the adsorption speed at the magnetic adsorption position and the adsorption stability at the liquid suction position at low cost. In addition, if the adsorption speed at the magnetic adsorption position is too slow, it is easy to cause the problem that all magnetic beads cannot be aggregated to the target position within the specified time, resulting in the loss of magnetic beads and the target substances bound to the magnetic beads, and further affecting the accuracy of the measurement result. If the adsorption stability at the liquid suction position is too poor, it is easy to cause some magnetic beads and the target substances bound to the magnetic beads to fall off during the fluctuation of the liquid suction process and be sucked away by the liquid suction component with other liquids, and further cause the problem of loss of magnetic beads and the target substances bound to the magnetic beads and affecting the accuracy of the measurement result. Summary of the Invention
[0004] The first object of the present invention is to provide one, which aims to solve the technical problem in the related art that it is difficult for the magnetic separation mechanism to take into account both the adsorption speed at the magnetic adsorption position and the adsorption stability at the liquid absorption position.
[0005] To achieve the above object, the solution provided by the present invention is: A sample analyzer, comprising:
[0006] A sample dispensing mechanism for sucking a sample from a sample container and dispensing it into a reaction container;
[0007] A reagent dispensing mechanism for at least sucking a first reagent from a first reagent container and dispensing it into the reaction container, wherein the first reagent contains magnetic beads;
[0008] A magnetic separation mechanism for performing a magnetic separation operation on the liquid in the reaction container, wherein the liquid in the reaction container is at least formed by the sample and the first reagent;
[0009] A measurement mechanism for measuring a test liquid formed at least by the liquid after the magnetic separation operation in the reaction container to obtain measurement information;
[0010] A controller configured to: output a measurement result of the sample according to the measurement information of the measurement mechanism;
[0011] Wherein, the magnetic separation mechanism includes a carrying member, a scheduling member, at least one first liquid absorption member, at least one first magnetic member and at least one second magnetic member. The first magnetic member includes two paired and spaced-apart first magnetic devices, and a first magnetic adsorption position is formed on one side of each first magnetic device. The first magnetic member is used to perform a first magnetic adsorption action on the liquid in the reaction container at the first magnetic adsorption position to adsorb and form two magnetic bead clusters on the inner side wall of the reaction container at the first magnetic adsorption position;
[0012] The second magnetic member is composed of a single second magnetic device, and a first liquid absorption position is formed on one side of the single second magnetic device. The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction container at the first liquid absorption position to adsorb and form a single magnetic bead cluster on the inner side wall of the reaction container at the first liquid absorption position;
[0013] The first liquid absorption member is used to perform a first liquid absorption action on the liquid in the reaction container at the first liquid absorption position;
[0014] The carrying member is at least used to carry the reaction container at the first magnetic adsorption position and carry the reaction container at the first liquid absorption position;
[0015] The scheduling member is at least used to schedule the reaction vessel to the first magnetic attraction position and to schedule the reaction vessel after the first magnetic adsorption action to the first liquid suction position.
[0016] As an implementation manner, the first magnetic attraction position is used to accommodate the reaction vessel to perform the first magnetic adsorption action but not the liquid suction action, and the first liquid suction position is used to accommodate the reaction vessel to perform the second magnetic adsorption action and the first liquid suction action.
[0017] As an implementation manner, a receiving groove for accommodating the reaction vessel is provided at the first magnetic attraction position;
[0018] The two first magnetic devices are arranged at intervals and oppositely along the radial direction of the receiving groove; or,
[0019] The two first magnetic devices are arranged at intervals and vertically along the axial direction of the receiving groove; or,
[0020] The two first magnetic devices are arranged at intervals and close to each other along the circumferential direction of the receiving groove.
[0021] As an implementation manner, the scheduling member is used to drive the carrying member to drive the reaction vessel to move to the first magnetic attraction position and the first liquid suction position in sequence;
[0022] The two first magnetic devices are respectively arranged on the opposite sides of the movement track of the scheduling member driving the reaction vessel or on one side of the movement track of the scheduling member driving the reaction vessel, and the second magnetic device is arranged on one side of the movement track.
[0023] As an implementation manner, the carrying member is in a disc shape, and the carrying member is formed with a plurality of receiving grooves arranged along the circumferential direction of the disc-shaped carrying member, and each receiving groove is used to accommodate one reaction vessel. The scheduling member is used to drive the carrying member to drive the reaction vessel to horizontally rotate around the central axis of the carrying member, so that the reaction vessels accommodated in the receiving grooves are sequentially scheduled to the first magnetic attraction position and the first liquid suction position.
[0024] As an implementation manner, the two first magnetic devices are respectively arranged on the opposite sides of the movement track; the number of the first magnetic attraction positions is at least two, and the number of the first liquid suction positions is at least two; the number of the first magnetic members is at least two and is arranged in sequence along the movement track, and the number of the second magnetic members is at least two and is arranged in sequence along the movement track;
[0025] The magnetic separation mechanism further includes a main bracket, a first mounting bracket and a second mounting bracket respectively connected to the main bracket. The first mounting bracket and the second mounting bracket are respectively located on opposite sides of the movement trajectory. The first mounting bracket is used to carry all the first magnetic devices and all the second magnetic devices provided on one side of the movement trajectory, and the second mounting bracket is used to carry all the first magnetic devices provided on the other side of the movement trajectory.
[0026] As an implementation manner, all the first magnetic devices are provided on one side of the movement trajectory, and all the second magnetic devices are also provided on this side of the movement trajectory.
[0027] As an implementation manner, the first magnetic device is composed of a single first magnet or two adjacent paired first magnets, and the second magnetic device is composed of a single second magnet or two adjacent paired second magnets;
[0028] One end of the two adjacent paired first magnets close to the first magnetic attraction position abuts against each other or one side of the two adjacent paired first magnets contacts each other. One end of the two adjacent paired second magnets close to the first magnetic attraction position abuts against each other or one side of the two adjacent paired second magnets contacts each other.
[0029] As an implementation manner, the two magnetic poles of the same first magnet are arranged in the horizontal direction or the vertical direction;
[0030] The two magnetic poles of the same second magnet are arranged in the horizontal direction or the vertical direction.
[0031] As an implementation manner, the first magnetic device is composed of two first magnets stacked in the vertical direction, and the second magnetic device is composed of two second magnets stacked in the vertical direction; or,
[0032] The first magnetic device is composed of two first magnets stacked in the vertical direction, and the second magnetic device is composed of a single second magnet; or,
[0033] The first magnetic device is composed of a single first magnet, and the second magnetic device is composed of a single second magnet; or,
[0034] The first magnetic device is composed of a single first magnet, and the second magnetic device is composed of two second magnets stacked in the vertical direction; or,
[0035] The first magnetic device is composed of two first magnets abutting against each other in the horizontal direction, and the second magnetic device is composed of two second magnets abutting against each other in the horizontal direction.
[0036] As an implementation manner, the two first magnetic devices are arranged at opposite sides of the first magnetic attraction position at intervals in the horizontal direction;
[0037] The first magnetic device is composed of two first magnets stacked in the vertical direction, and the second magnetic device is composed of two second magnets stacked in the vertical direction;
[0038] The two magnetic poles of the same first magnet are arranged in the horizontal direction, and the two magnetic poles of the same second magnet are arranged in the horizontal direction;
[0039] In the same first magnetic device, the polarities of the magnetic poles of the two first magnets stacked in the vertical direction facing the same first magnetic attraction position are opposite, and in the second magnetic device, the polarities of the magnetic poles of the two second magnets stacked in the vertical direction facing the same first liquid suction position are opposite;
[0040] In the two first magnetic devices of the same first magnetic member that are paired and arranged at intervals, the polarities of the magnetic poles of the two first magnets distributed on opposite sides of the same first magnetic attraction position and at the same height position facing the same first magnetic attraction position are the same.
[0041] As an implementation manner, the height position where the first magnetic member is located is lower than the height position where the second magnetic member is located.
[0042] As an implementation manner, at least two first magnetic attraction positions are formed on one side of each first magnetic device and are sequentially distributed along the movement track of the scheduling member for driving the reaction vessel; and / or,
[0043] At least two first liquid suction positions are formed on one side of the second magnetic device and are sequentially distributed along the movement track of the scheduling member for driving the reaction vessel.
[0044] As an implementation manner, the magnetic separation mechanism further includes at least one third magnetic member. The third magnetic member is composed of a single third magnetic device. A second magnetic attraction position is formed on one side of the single third magnetic device. The third magnetic member is used to perform a third magnetic adsorption action on the liquid in the reaction vessel at the second magnetic attraction position to adsorb and form a single magnetic bead group on the inner side wall of the reaction vessel at the second magnetic attraction position;
[0045] The scheduling member schedules the reaction vessel that has completed the first magnetic adsorption action to the first liquid suction position, including: first scheduling the reaction vessel that has completed the first magnetic adsorption action to the second magnetic attraction position, and then scheduling the reaction vessel that has completed the third magnetic adsorption action to the first liquid suction position.
[0046] As an implementation manner, the first magnetic attraction position, the second magnetic attraction position and the first liquid suction position are sequentially distributed along the movement track of the scheduling member for driving the reaction vessel;
[0047] The third magnetic device is arranged on one side of the movement track of the scheduling member for driving the reaction vessel, and the second magnetic device is also arranged on this side of the movement track.
[0048] As an implementation manner, the magnetic separation mechanism further includes at least one first liquid injection member, at least one mixing member, at least one fourth magnetic member, at least one fifth magnetic member and at least one second liquid suction member. The fourth magnetic member includes two paired and spaced fourth magnetic devices, and a third magnetic attraction position is formed on one side of each fourth magnetic device. The fourth magnetic member is used to perform a fourth magnetic adsorption action on the liquid in the reaction vessel located at the third magnetic attraction position to adsorb and form two magnetic bead clusters on the inner side wall of the reaction vessel located at the third magnetic attraction position;
[0049] The fifth magnetic member is composed of a single fifth magnetic device, and a second liquid suction position is formed on one side of the single fifth magnetic device. The fifth magnetic member is used to perform a fifth magnetic adsorption action on the liquid in the reaction vessel located at the second liquid suction position to adsorb and form a single magnetic bead cluster on the inner side wall of the reaction vessel located at the second liquid suction position;
[0050] The second liquid suction member is used to perform a second liquid suction action on the liquid in the reaction vessel located at the second liquid suction position;
[0051] The scheduling member is further used to sequentially schedule the reaction vessel after completing the first liquid suction action to the first liquid injection position, the mixing position, the third magnetic attraction position, and the second liquid suction position. The carrying member is further used to carry the reaction vessel located at the first liquid injection position, carry the reaction vessel located at the mixing position, carry the reaction vessel located at the third magnetic attraction position, and carry the reaction vessel located at the second liquid suction position;
[0052] The first liquid injection member is used to perform a first liquid injection action of injecting a cleaning liquid on the reaction vessel located at the first liquid injection position and after completing the first liquid suction action;
[0053] The mixing member is used to perform a mixing action on the reaction vessel located at the mixing position and after completing the first liquid injection action;
[0054] Wherein, the third magnetic attraction position and the first magnetic attraction position are located at two different positions or at the same position, the second liquid suction position and the first liquid suction position are located at two different positions or at the same position, and the first liquid injection position and the first liquid suction position are located at two different positions or at the same position.
[0055] As an implementation manner, the magnetic separation mechanism further includes at least one sixth magnetic member, the sixth magnetic member is composed of a single sixth magnetic device, a fourth magnetic attraction position is formed on one side of the single sixth magnetic device, the sixth magnetic member is used to perform a sixth magnetic adsorption action on the liquid in the reaction vessel at the fourth magnetic attraction position to adsorb and form a single magnetic bead group on the inner side wall of the reaction vessel at the fourth magnetic attraction position, the carrying member is further used to carry the reaction vessel at the fourth magnetic attraction position, and the scheduling member schedules the reaction vessel after completing the fourth magnetic adsorption action at the third magnetic attraction position to the second liquid suction position, including: first scheduling the reaction vessel after completing the fourth magnetic adsorption action at the third magnetic attraction position to the fourth magnetic attraction position, and then scheduling the reaction vessel after completing the sixth magnetic adsorption action at the fourth magnetic attraction position to the second liquid suction position; and / or,
[0056] The magnetic separation mechanism further includes at least one seventh magnetic member, at least one second liquid injection member, and at least one third liquid suction member. The seventh magnetic member is composed of a single seventh magnetic device, a third liquid suction position is formed on one side of the single seventh magnetic device, the seventh magnetic member is used to perform a seventh magnetic adsorption action on the liquid in the reaction vessel at the third liquid suction position to adsorb and form a single magnetic bead group on the inner side wall of the reaction vessel at the third liquid suction position, the scheduling member is further used to sequentially schedule the reaction vessel after completing the second liquid suction action to the second liquid injection position and the third liquid suction position, the carrying member is further used to carry the reaction vessel at the second liquid injection position and the reaction vessel at the third liquid suction position, the second liquid injection member is used to perform a second liquid injection action of injecting a cleaning liquid on the reaction vessel at the second liquid injection position and after completing the second liquid suction action, and the third liquid suction member is used to perform a third liquid suction action on the liquid in the reaction vessel at the third liquid suction position, wherein the second liquid injection position and the second liquid suction position are located at two different positions or at the same position.
[0057] The second object of the present invention is to provide a sample analyzer, which includes:
[0058] A sample distribution mechanism, which is used to suck a sample from a sample container and distribute it into a reaction container;
[0059] A reagent dispensing mechanism, which is at least used to aspirate a first reagent from a first reagent container and dispense it into a reaction container, and the first reagent contains magnetic beads;
[0060] A magnetic separation mechanism, which is used to perform a magnetic separation operation on the liquid in the reaction container, and the liquid in the reaction container is formed by the sample and the first reagent;
[0061] A measurement mechanism, which is used to measure a test liquid made at least from the liquid after the magnetic separation operation in the reaction container to obtain measurement information;
[0062] A controller, which is configured to: output a measurement result of the sample according to the measurement information of the measurement mechanism;
[0063] Wherein, the magnetic separation mechanism includes a bearing member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member. The first magnetic member is composed of a single first magnetic device, and the single first magnetic device is composed of at least three first magnets stacked in the vertical direction or at least three first magnets abutting against each other in the horizontal direction. A first magnetic attraction position is formed on one side of the single first magnetic device, and the first magnetic member is used to perform a first magnetic adsorption action on the liquid in the reaction container located at the first magnetic attraction position to adsorb and form at least two magnetic bead clusters on the inner side wall of the reaction container located at the first magnetic attraction position;
[0064] The second magnetic member is composed of a single second magnetic device, and the single second magnetic member is composed of a second magnet or at least two second magnets abutting against each other in the horizontal direction or at least two second magnets stacked in the vertical direction. The number of the first magnets included in the single first magnetic device is greater than the number of the second magnets included in the single second magnetic device. A first liquid suction position is formed on one side of the single second magnetic device, and the second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction container located at the first liquid suction position to adsorb and form at least one magnetic bead cluster on the inner side wall of the reaction container located at the first magnetic attraction position;
[0065] The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position;
[0066] The bearing member is at least used to bear the reaction container located at the first magnetic attraction position and bear the reaction container located at the first liquid suction position;
[0067] The scheduling member is at least used to schedule the reaction vessel loaded with the liquid to the first magnetic attraction position, and to schedule the reaction vessel after the first magnetic adsorption action to the first liquid suction position.
[0068] As an implementation manner, the first magnetic device is composed of at least three first magnets stacked in the vertical direction, and the second magnetic device is composed of a single second magnet or two second magnets stacked in the vertical direction; or,
[0069] The first magnetic device is composed of at least three first magnets abutting against each other in the horizontal direction, and the second magnetic device is composed of a single second magnet or two second magnets abutting against each other in the horizontal direction.
[0070] As an implementation manner, the scheduling member is used to drive the bearing member to drive the reaction vessel loaded with the liquid to move to the first magnetic attraction position and the first liquid suction position in sequence;
[0071] The first magnetic device and the second magnetic device are arranged on the same side of the movement track of the scheduling member driving the reaction vessel to move;
[0072] Preferably, the bearing member is in a disc shape, and the bearing member is formed with a plurality of accommodating grooves arranged along the circumference of the disc-shaped bearing member. Each accommodating groove is used to accommodate a reaction vessel, and the scheduling member is used to drive the bearing member to drive the reaction vessel to rotate horizontally around the central axis of the bearing member, so that the reaction vessels accommodated in the accommodating grooves are sequentially scheduled to the first magnetic attraction position and the first liquid suction position.
[0073] The third object of the present invention is to provide a sample analyzer, which includes:
[0074] A sample distribution mechanism, which is used to suck samples from a sample container and distribute them into a reaction vessel;
[0075] A reagent distribution mechanism, which is at least used to suck a first reagent from a first reagent container and distribute it into a reaction vessel, and the first reagent contains magnetic beads;
[0076] A magnetic separation mechanism, which is used to perform a magnetic separation operation on the liquid in the reaction vessel, and the liquid in the reaction vessel is formed by the sample and the first reagent;
[0077] A determination mechanism, which is used to determine the liquid to be measured formed at least by the liquid after the magnetic separation operation in the reaction vessel to obtain determination information;
[0078] A controller configured to output a measurement result of the sample according to the measurement information of the measurement mechanism.
[0079] Wherein, the magnetic separation mechanism includes a carrying member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member. The first magnetic member includes at least two first magnets arranged at intervals, and a first magnetic adsorption position is formed between the at least two first magnets arranged at intervals. The first magnetic member is used to perform a first magnetic adsorption action on the liquid in the reaction vessel located at the first magnetic adsorption position.
[0080] The second magnetic member is composed of one second magnet or at least two second magnets. A first liquid suction position is formed on one side of the one second magnet, or on one side of the at least two second magnets, or between the at least two second magnets. The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction vessel located at the first liquid suction position. The number of the first magnets included in one first magnetic member is greater than the number of the second magnets included in one second magnetic member.
[0081] The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction vessel located at the first liquid suction position.
[0082] The carrying member is at least used to carry the reaction vessel located at the first magnetic adsorption position and carry the reaction vessel located at the first liquid suction position.
[0083] The scheduling member is at least used to schedule the reaction vessel loaded with the liquid to the first magnetic adsorption position, and schedule the reaction vessel after the first magnetic adsorption action is completed to the first liquid suction position.
[0084] As an implementation manner, the first magnetic member is composed of four first magnets, and the four first magnets are arranged in pairs on opposite sides of the first magnetic adsorption position. The second magnetic member is composed of one second magnet arranged on one side of the first liquid suction position, or two second magnets stacked on one side of the first liquid suction position, or two second magnets arranged in contact with each other horizontally on one side of the first liquid suction position; or
[0085] The first magnetic member is composed of two first magnets, and the two first magnets are respectively arranged on opposite sides of the first magnetic adsorption position. The second magnetic member is composed of one second magnet arranged on one side of the first liquid suction position, or two second magnets stacked on one side of the first liquid suction position, or two second magnets arranged in contact with each other horizontally on one side of the first liquid suction position.
[0086] The fourth object of the present invention is to provide a sample analyzer, which comprises:
[0087] A sample dispensing mechanism for sucking a sample from a sample container and dispensing it into a reaction container;
[0088] A reagent dispensing mechanism for at least sucking a first reagent from a first reagent container and dispensing it into the reaction container, wherein the first reagent contains magnetic beads;
[0089] A magnetic separation mechanism for performing a magnetic separation operation on the liquid in the reaction container;
[0090] A measurement mechanism for measuring a test liquid formed at least from the liquid after the magnetic separation operation in the reaction container to obtain measurement information;
[0091] A controller configured to output a measurement result of the sample according to the measurement information of the measurement mechanism;
[0092] Wherein, the magnetic separation mechanism includes a carrying member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member, and the scheduling member is used to sequentially schedule the reaction container loaded with the liquid along a preset track to a first magnetic attraction position and a first liquid suction position;
[0093] The carrying member is at least used to carry the reaction container located at the first magnetic attraction position and the reaction container located at the first liquid suction position;
[0094] The first magnetic member is used to perform a first magnetic adsorption action on the liquid in the reaction container located at the first magnetic attraction position to adsorb and form a first number of magnetic bead clusters on the inner side wall of the reaction container located at the first magnetic attraction position;
[0095] The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction container located at the first liquid suction position to adsorb and form a second number of magnetic bead clusters on the inner side wall of the reaction container located at the first liquid suction position;
[0096] The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position;
[0097] The first number is greater than or equal to two, and the first number is greater than the second number.
[0098] As an implementation manner, when the first magnetic member performs the first magnetic adsorption action, at least two bead clusters arranged along the circumferential direction of the reaction vessel are adsorbed and formed on the inner side wall of the reaction vessel at the first magnetic adsorption position; when the second magnetic member performs the second magnetic adsorption action, a single bead cluster is adsorbed and formed on the inner side wall of the reaction vessel at the first liquid adsorption position; and / or,
[0099] The first magnetic member includes at least two first magnets spaced at intervals in the horizontal circumferential direction, and the second magnetic member is composed of a single second magnet or two second magnets stacked in the vertical direction.
[0100] As an implementation manner, when the first magnetic member performs the first magnetic adsorption action, at least two bead clusters arranged along the height direction of the reaction vessel are adsorbed and formed on the inner side wall of the reaction vessel at the first magnetic adsorption position; when the second magnetic member performs the second magnetic adsorption action, a single bead cluster is adsorbed and formed on the inner side wall of the reaction vessel at the first liquid adsorption position; and / or,
[0101] The first magnetic member includes at least three first magnets stacked in the vertical direction, and the second magnetic member is composed of a single second magnet or two second magnets stacked in the vertical direction.
[0102] As an implementation manner, the orthographic projection of the first magnetic member on the reaction vessel at the first magnetic adsorption position is located between the liquid level in the reaction vessel and the inner bottom surface of the reaction vessel;
[0103] At least a part of the orthographic projection of the second magnetic member on the reaction vessel at the first liquid adsorption position is located above the liquid level of the liquid in the reaction vessel and / or below the inner bottom surface of the reaction vessel.
[0104] As an implementation manner, the height position where the bead cluster adsorbed and formed on the inner side wall of the reaction vessel by the first magnetic member when performing the first magnetic adsorption action is lower than the height position where the bead cluster adsorbed and formed on the inner side wall of the reaction vessel by the second magnetic member when performing the second magnetic adsorption action; and / or,
[0105] The height position where the first magnetic member is located is lower than the height position where the second magnetic member is located.
[0106] As an implementation manner, the first magnetic member is composed of a first magnetic device or at least two first magnetic devices arranged at intervals, the second magnetic member is composed of a second magnetic device or at least two second magnetic devices arranged at intervals, the first magnetic device is composed of at least one first magnet, and the second magnetic device is composed of at least one second magnet; and the number of the first magnets included in one of the first magnetic devices is greater than or equal to the number of the second magnets included in the second magnetic device or one less than the number of the second magnets included in the second magnetic device.
[0107] As an implementation manner, the first magnetic member is composed of a single first magnetic device, the second magnetic member is composed of at least two second magnetic devices arranged at intervals, the first magnetic device is composed of at least four first magnets abutting in sequence, the second magnetic device is composed of a single second magnet or two second magnets abutting against each other, and the number of the first magnets included in the first magnetic member is at least two more than the number of the second magnetic devices included in the second magnetic member.
[0108] As an implementation manner, the first magnetic member is composed of at least two first magnetic devices arranged at intervals, and the second magnetic member is composed of a single second magnetic device; or,
[0109] The first magnetic member is composed of at least two first magnetic devices arranged at intervals, and the second magnetic member is composed of at least two second magnetic devices arranged at intervals. The first magnetic device is composed of a single first magnet or at least two first magnets stacked in the vertical direction or abutting in sequence in the horizontal direction, and the second magnetic device is composed of a single second magnet or at least two second magnets stacked in the vertical direction or abutting in sequence in the horizontal direction. One of the following two parameter groups of the first magnetic member and the second magnetic member has the former parameter greater than the latter parameter, and the former parameter of the other parameter group is greater than or equal to the latter parameter: the number of the first magnetic devices and the number of the second magnetic devices, and the interval distance between two adjacent first magnetic devices in the same first magnetic member and the interval distance between two adjacent second magnetic devices in the same second magnetic member.
[0110] As an implementation manner, the first magnetic member is composed of at least three first magnetic devices arranged at intervals, the second magnetic member is composed of two second magnetic devices arranged at intervals, and the interval distance between two adjacent first magnetic devices in the same first magnetic member is greater than or equal to the interval distance between two adjacent second magnetic devices in the same second magnetic member; or,
[0111] The first magnetic member is composed of two first magnetic devices arranged at intervals, and the second magnetic member is composed of two second magnetic devices arranged at intervals. The distance between two adjacent first magnetic devices in the same first magnetic member is greater than the distance between two adjacent second magnetic devices in the same second magnetic member.
[0112] The fifth object of the present invention is to provide a sample analyzer, which includes:
[0113] A sample dispensing mechanism for sucking a sample from a sample container and dispensing it into a reaction container;
[0114] A reagent dispensing mechanism for at least sucking a first reagent from a first reagent container and dispensing it into the reaction container, where the first reagent contains magnetic beads;
[0115] A magnetic separation mechanism for performing a magnetic separation operation on the liquid in the reaction container, where the liquid in the reaction container is at least formed by the sample and the first reagent;
[0116] A measurement mechanism for measuring a test liquid at least formed by the liquid after the magnetic separation operation in the reaction container to obtain measurement information;
[0117] A controller configured to: output a measurement result of the sample according to the measurement information of the measurement mechanism;
[0118] Among them, the magnetic separation mechanism includes a carrying member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member. The scheduling member is used to sequentially schedule the reaction container loaded with the liquid along a preset track to a first magnetic attraction position and a first liquid suction position;
[0119] The carrying member is at least used to carry the reaction container located at the first magnetic attraction position and the reaction container located at the first liquid suction position;
[0120] The first magnetic member is used to perform a first magnetic adsorption action on the liquid in the reaction container located at the first magnetic attraction position to adsorb and form a first magnetic bead group on the inner side wall of the reaction container located at the first magnetic attraction position;
[0121] The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction container located at the first liquid suction position to adsorb and form a second magnetic bead group on the inner side wall of the reaction container located at the first liquid suction position;
[0122] The first liquid suction member is configured to perform a first liquid suction action on the liquid in the reaction vessel located at the first liquid suction level;
[0123] The adsorption area of the first magnetic bead group on the side wall of the reaction vessel is larger than the adsorption area of the second magnetic bead group on the side wall of the reaction vessel.
[0124] As an implementation manner, the first magnetic member includes an annular magnet, and the closed inner side wall of the annular magnet encloses to form the first magnetic adsorption position. The second magnetic member is composed of one or two second magnets distributed on one side of the first liquid suction level; or,
[0125] The first magnetic member is composed of a single first magnet distributed on one side of the first magnetic adsorption position. The second magnetic member is composed of one second magnet or two second magnets distributed on one side of the first liquid suction level and stacked vertically. The volume of the first magnetic member is larger than the volume of the second magnetic member.
[0126] The sixth object of the present invention is to provide a magnetic separation mechanism, which includes a carrying member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member. The first magnetic member includes two paired and spaced-apart first magnetic devices, and a first magnetic adsorption position is formed on one side of each first magnetic device. The first magnetic member is configured to perform a first magnetic adsorption action on the liquid in the reaction vessel located at the first magnetic adsorption position to adsorb and form two magnetic bead groups on the inner side wall of the reaction vessel located at the first magnetic adsorption position;
[0127] The second magnetic member is composed of a single second magnetic device, and a first liquid suction level is formed on one side of the single second magnetic device. The second magnetic member is configured to perform a second magnetic adsorption action on the liquid in the reaction vessel located at the first liquid suction level to adsorb and form a single magnetic bead group on the inner side wall of the reaction vessel located at the first liquid suction level;
[0128] The first liquid suction member is configured to perform a first liquid suction action on the liquid in the reaction vessel located at the first liquid suction level;
[0129] The carrying member is at least configured to carry the reaction vessel located at the first magnetic adsorption position and carry the reaction vessel located at the first liquid suction level;
[0130] The scheduling member is at least configured to schedule the reaction vessel to the first magnetic adsorption position and schedule the reaction vessel after completing the first magnetic adsorption action to the first liquid suction level.
[0131] The seventh object of the present invention is to provide a magnetic separation mechanism, which includes a bearing member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member. The first magnetic member is composed of a single first magnetic device, and the single first magnetic device is composed of at least three first magnets stacked in the vertical direction or at least three first magnets abutting against each other in the horizontal direction. A first magnetic suction position is formed on one side of the single first magnetic device. The first magnetic member is used to perform a first magnetic adsorption action on the liquid in the reaction vessel located at the first magnetic suction position to adsorb and form at least two magnetic bead clusters on the inner side wall of the reaction vessel located at the first magnetic suction position;
[0132] The second magnetic member is composed of a single second magnetic device, and the single second magnetic member is composed of a second magnet or at least two second magnets abutting against each other in the horizontal direction or at least two second magnets stacked in the vertical direction. The number of the first magnets included in the single first magnetic device is greater than the number of the second magnets included in the single second magnetic device. A first liquid suction position is formed on one side of the single second magnetic device. The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction vessel located at the first liquid suction position to adsorb and form at least one magnetic bead cluster on the inner side wall of the reaction vessel located at the first magnetic suction position;
[0133] The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction vessel located at the first liquid suction position;
[0134] The bearing member is at least used to bear the reaction vessel located at the first magnetic suction position and bear the reaction vessel located at the first liquid suction position;
[0135] The scheduling member is at least used to schedule the reaction vessel to the first magnetic suction position and schedule the reaction vessel after the first magnetic adsorption action is completed to the first liquid suction position.
[0136] The eighth object of the present invention is to provide a magnetic separation mechanism, which includes a bearing member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member. The first magnetic member includes at least two first magnets arranged at intervals, and a first magnetic suction position is formed between the at least two first magnets arranged at intervals. The first magnetic member is used to perform a first magnetic adsorption action on the liquid in the reaction vessel located at the first magnetic suction position;
[0137] The second magnetic member is composed of one second magnet or at least two second magnets. A first liquid suction position is formed on one side of the one second magnet, or on one side of the at least two second magnets, or between the at least two second magnets. The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction vessel located at the first liquid suction position. The number of the first magnets included in one first magnetic member is greater than the number of the second magnets included in one second magnetic member;
[0138] The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction vessel located at the first liquid suction position;
[0139] The carrying member is at least used to carry the reaction vessel located at the first magnetic adsorption position and carry the reaction vessel located at the first liquid suction position;
[0140] The scheduling member is at least used to schedule the reaction vessel to the first magnetic adsorption position and schedule the reaction vessel after completing the first magnetic adsorption action to the first liquid suction position.
[0141] The ninth object of the present invention is to provide a magnetic separation mechanism, which includes a carrying member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member. The scheduling member is used to sequentially schedule the reaction vessel along a preset track to the first magnetic adsorption position and the first liquid suction position;
[0142] The carrying member is at least used to carry the reaction vessel located at the first magnetic adsorption position and carry the reaction vessel located at the first liquid suction position;
[0143] The first magnetic member is used to perform a first magnetic adsorption action on the liquid in the reaction vessel located at the first magnetic adsorption position to adsorb and form a first number of magnetic bead clusters on the inner side wall of the reaction vessel located at the first magnetic adsorption position;
[0144] The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction vessel located at the first liquid suction position to adsorb and form a second number of magnetic bead clusters on the inner side wall of the reaction vessel located at the first liquid suction position;
[0145] The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction vessel located at the first liquid suction position;
[0146] The first number is greater than or equal to two, and the first number is greater than the second number.
[0147] The sample analyzer and magnetic separation mechanism provided by the present invention set the first magnetic component at the first magnetic attraction position and the second magnetic component at the first liquid suction position in a different manner, so as to meet the design requirements of the adsorption speed at the magnetic attraction position and the adsorption stability at the liquid suction position. Specifically, the present invention sets two pairs of first magnetic devices arranged at intervals at the first magnetic attraction position to adsorb and form two magnetic bead clusters on the inner side wall of the reaction vessel located at the first magnetic attraction position. In this way, since the two pairs of first magnetic devices arranged at intervals at the first magnetic attraction position can adsorb magnetic beads and the target substances bound to the magnetic beads from different directions, the distance that the magnetic beads and the target substances bound to the magnetic beads are adsorbed and moved can be shortened, so that the magnetic beads and the target substances bound to the magnetic beads can be quickly adsorbed to the inner side wall of the reaction vessel, which is beneficial to ensuring the adsorption speed at the first magnetic attraction position. In addition, the present invention sets a single second magnetic device on one side of the first liquid suction position to adsorb and form a single magnetic bead cluster on the inner side wall of the reaction vessel located at the first liquid suction position, that is, all the magnetic beads and the target substances bound to the magnetic beads are adsorbed and aggregated into a magnetic bead cluster, thereby facilitating the increase of the adsorption stability of the magnetic beads and the target substances bound to the magnetic beads during liquid suction. BRIEF DESCRIPTION OF THE DRAWINGS
[0148] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on the structures shown in these drawings.
[0149] Figure 1 is a schematic structural diagram of the sample analyzer provided in the first embodiment of the present invention;
[0150] Figure 2 is a schematic structural diagram of the magnetic separation mechanism provided in the first embodiment of the present invention;
[0151] Figure 3 is a schematic distribution diagram of each working position on the magnetic separation mechanism provided in the first embodiment of the present invention;
[0152] Figure 4 is a schematic diagram of the distribution of the magnetic components at the first magnetic attraction position and the first liquid suction position and the distribution of the magnetic bead clusters formed by adsorption provided in the first embodiment of the present invention;
[0153] Figure 5 is a schematic structural diagram of the first module provided in the first embodiment of the present invention;
[0154] Figure 6 is a schematic structural diagram of the second module provided in the first embodiment of the present invention;
[0155] Figure 7 It is a schematic structural diagram of the first liquid absorption member and the third liquid injection member provided in the first embodiment of the present invention;
[0156] Figure 8 It is a schematic diagram of the mixing member in the mixing working state provided in the first embodiment of the present invention;
[0157] Figure 9 It is a schematic diagram of the mixing member in the non - mixing working state provided in the first embodiment of the present invention;
[0158] Figure 10 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the second embodiment of the present invention;
[0159] Figure 11 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the third embodiment of the present invention;
[0160] Figure 12 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the fourth embodiment of the present invention;
[0161] Figure 13 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the fifth embodiment of the present invention;
[0162] Figure 14 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the sixth embodiment of the present invention;
[0163] Figure 15 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the seventh embodiment of the present invention;
[0164] Figure 16 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the eighth embodiment of the present invention;
[0165] Figure 17 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the eleventh embodiment of the present invention;
[0166] Figure 18 It is a schematic diagram of the distribution of magnetic members and the distribution of magnetic bead clusters formed by adsorption at the first magnetic attraction position and the first liquid absorption position provided in the twelfth embodiment of the present invention.
[0167] Description of the attached reference numerals: 10, sample analyzer; 100, magnetic separation mechanism; 110, first magnetic member; 111, first magnetic device; 1111, first magnet; 120, second magnetic member; 121, second magnetic device; 1211, second magnet; 130, first liquid suction member; 140, carrier member; 141, support component; 150, scheduling member; 160, third magnetic member; 161, third magnetic device; 170, third liquid injection member; 180, mixing member; 181, pressing member; 182, rotation driving member; 183, lifting driving member; 190, fourth magnetic member; 191, fourth magnetic device; 101, fifth magnetic member; 1011, fifth magnetic device; 102, second liquid suction member; 103, sixth magnetic member; 1031, sixth magnetic device; 104, seventh magnetic member; 1041, seventh magnetic device; 105, eighth magnetic member; 1051, eighth magnetic device; 106, first module; 1061, first mounting bracket; 107, second module; 1071, second mounting bracket; 108, fifth liquid injection member; 109, third liquid suction member; 1001, first magnetic attraction position; 1002, first liquid suction position; 1003, second magnetic attraction position; 1004, third magnetic attraction position; 1005, second liquid suction position; 1006, first liquid injection position; 1007, mixing position; 1008, fourth magnetic attraction position; 1009, third liquid suction position; 1091, avoidance position; 1092, fourth liquid suction position; 1093, substrate distribution position; 1094, picking and placing position; 200, measuring mechanism; 300, controller; 400, incubation mechanism; 500, substrate distribution mechanism; 600, sample distribution mechanism; 700, reagent distribution mechanism; 800, reagent storage mechanism; 900, reaction vessel providing mechanism; 910, transfer mechanism; 920, sample management mechanism; 930, sample conveying mechanism; 20, reaction vessel; 30, magnetic bead cluster. Detailed implementation manners
[0168] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.
[0169] In the present invention, the descriptions involving "first", "second", etc. are for descriptive purposes only, and should not be construed as indicating or implying their relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature. Additionally, the technical solutions between various embodiments may be combined with each other, but it must be based on the ability of those of ordinary skill in the art to implement. When the combination of technical solutions results in contradictions or is unachievable, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.
[0170] Embodiment 1:
[0171] As Figures 1 to 9 shown, the sample analyzer 10 provided in Embodiment 1 of the present invention includes a magnetic separation mechanism 100, a measurement mechanism 200, and a controller 300. The magnetic separation mechanism 100 is configured to perform a magnetic separation operation on the liquid in the reaction vessel 20. The measurement mechanism 200 is configured to measure the test liquid formed at least from the liquid after the magnetic separation operation in the reaction vessel 20 to obtain measurement information. The controller 300 is configured to: output the measurement result of the sample according to the measurement information of the measurement mechanism 200. The magnetic separation operation is mainly used to separate the liquid in the reaction vessel 20 into a test portion and an impurity portion by magnetic attraction to achieve liquid purification. The magnetic separation mechanism 100 is at least configured to perform the following actions: perform a magnetic adsorption treatment on the liquid in the reaction vessel 20, and perform a liquid suction treatment on the liquid in the reaction vessel 20. The reaction vessel 20 is used to hold the liquid containing at least the sample for magnetic separation and measurement. It should be noted that the reaction vessel 20 used to hold the liquid in the magnetic separation operation and the reaction vessel 20 used to hold the test liquid in the measurement may be the same reaction vessel 20, or two independent reaction vessels 20, that is: the magnetic separation operation may not perform a transfer operation on the test portion, so that the test portion remains in the same reaction vessel 20 for magnetic separation and measurement; or, the magnetic separation operation may also transfer the test portion from one reaction vessel 20 to another reaction vessel 20 for the measurement step.
[0172] Referring to 1 and Figure 2As shown, as an implementation, the sample analyzer 10 further includes an incubation mechanism 400 for incubating the liquid formed at least by the sample and the first reagent in the reaction vessel 20, and a magnetic separation mechanism 100 for performing a magnetic separation operation on the liquid in the reaction vessel 20 after incubation. The first reagent contains magnetic beads. The incubation mechanism 400 is mainly used to provide a suitable reaction environment (such as a temperature environment within a preset range) for the sample and the first reagent, so that the sample and the first reagent can react fully and quickly. The reaction vessel 20 used to carry the sample and the first reagent for incubation during the incubation operation and the reaction vessel 20 used to carry the liquid for magnetic separation during the magnetic separation operation can be the same reaction vessel 20, or can be two independent reaction vessels 20. Of course, in specific applications, as an alternative implementation, the sample and the first reagent can also be incubated in an incubation device independently set outside the sample analyzer 10 and then placed in the sample analyzer 10 for magnetic separation and determination.
[0173] Refer to 1 to Figure 3 As shown, as an implementation, the magnetic separation mechanism 100 includes a carrying member 140, a scheduling member 150, at least one first liquid suction member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The scheduling member 150 is at least used to schedule the reaction vessel 20 loaded with the incubated liquid to the first magnetic adsorption position 1001, and to schedule the reaction vessel 20 after the first magnetic adsorption action is completed at the first magnetic adsorption position 1001 to the first liquid suction position 1002. The carrying member 140 is at least used to carry the reaction vessel 20 located at the first magnetic adsorption position 1001 and to carry the reaction vessel 20 located at the first liquid suction position 1002. The first magnetic member 110 is used to provide a magnetic field for the first magnetic adsorption position 1001 to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic adsorption position 1001. The second magnetic member 120 is used to provide a magnetic field for the first liquid suction position 1002 to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002. The first liquid suction member 130 is used to perform a first liquid suction action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002. The magnetic adsorption action at the first magnetic adsorption position 1001 and the liquid suction action at the first liquid suction position 1002 can be carried out in parallel, which is conducive to ensuring the magnetic separation efficiency of batch samples. The magnetic adsorption action at the first magnetic adsorption position 1001 is mainly used to adsorb the magnetic beads in the reaction vessel 20 and the target substance (the target substance here can be the analyte or can also be an interfering substance) combined with the magnetic beads to a specified position as quickly as possible to form a magnetic bead cluster 30 on the inner wall of the reaction vessel 20. The magnetic adsorption action at the first liquid suction position 1002 is mainly used to adsorb the magnetic beads in the reaction vessel 20 and the target substance combined with the magnetic beads on the inner wall of the reaction vessel 20 as stably as possible.
[0174] As an implementation manner, the first magnetic adsorption position 1001 is used to accommodate the reaction vessel 20 to perform the first magnetic adsorption action but not the liquid suction action. The first liquid suction position 1002 is used to accommodate the reaction vessel 20 to perform the second magnetic adsorption action and the first liquid suction action. That is, the liquid in the reaction vessel 20 only performs the magnetic adsorption action but not the liquid suction action at the first magnetic adsorption position 1001, and the liquid in the reaction vessel 20 at the first liquid suction position 1002 performs both the magnetic adsorption action and the liquid suction action.
[0175] Referring to Figure 3 and Figure 4 As shown, as an implementation manner, the first magnetic member 110 is used to adsorb and form at least two magnetic bead clusters 30 on the inner side wall of the reaction vessel 20 located at the first magnetic adsorption position 1001. The second magnetic member 120 is used to adsorb and form at least one magnetic bead cluster 30 on the inner side wall of the reaction vessel 20 located at the first liquid suction position 1002. The first liquid suction member 130 is used to perform the first liquid suction action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002 and subjected to the second magnetic adsorption action by the first magnetic member 110. The number of magnetic bead clusters 30 adsorbed and formed by the first magnetic member 110 on the inner side wall of the reaction vessel 20 located at the first magnetic adsorption position 1001 is greater than the number of magnetic bead clusters 30 adsorbed and formed by the second magnetic member 120 on the inner side wall of the reaction vessel 20 located at the first liquid suction position 1002. The first magnetic member 110 adsorbs and forms at least two magnetic bead clusters 30 on the inner side wall of the reaction vessel 20 located at the first magnetic adsorption position 1001 mainly because the first magnetic member 110 forms at least two dispersed magnetic fields at the first magnetic adsorption position 1001. The at least two dispersed magnetic fields can adsorb the magnetic beads and the target substances combined with the magnetic beads in the reaction vessel 20 located at the first magnetic adsorption position 1001 from different directions, so that the moving distance of the adsorbed magnetic beads and the target substances combined with the magnetic beads can be shortened, and the magnetic beads and the target substances combined with the magnetic beads can be quickly and proximally adsorbed to the inner side wall of the reaction vessel 20, which is beneficial to ensuring the adsorption speed at the first magnetic adsorption position 1001. In this implementation scheme, by setting the first magnetic member 110 at the first magnetic adsorption position 1001 and the second magnetic member 120 at the first liquid suction position 1002 in different ways, and making the number of magnetic bead clusters 30 adsorbed and formed by the first magnetic member 110 in one reaction vessel 20 greater than the number of magnetic bead clusters 30 adsorbed and formed by the second magnetic member 120 in one reaction vessel 20, it is beneficial to ensure both the adsorption speed at the first magnetic adsorption position 1001 and the adsorption stability at the first liquid suction position 1002.
[0176] As an implementation manner, at least two bead clusters 30 adsorbed and formed by the first magnetic member 110 on the inner sidewall of the reaction vessel 20 located at the first magnetic adsorption position 1001 are spaced apart, that is, there is a spacing between at least two bead clusters 30 adsorbed and formed by the first magnetic member 110 and they are not connected. Of course, in specific applications, as an alternative implementation manner, at least two bead clusters 30 adsorbed and formed by the first magnetic member 110 on the inner sidewall of the reaction vessel 20 located at the first magnetic adsorption position 1001 may also be connected together at local edges.
[0177] As an implementation manner, a first magnetic adsorption position 1001 is formed between or on one side of the first magnetic members 110, that is: the first magnetic members 110 may be distributed in at least two directions of the first magnetic adsorption position 1001 along the horizontal circumferential direction, or may be distributed on one side of the first magnetic adsorption position 1001, as long as it is ensured that the magnetic field provided by the first magnetic members 110 for the first magnetic adsorption position 1001 can adsorb and form at least two bead clusters 30 on the inner sidewall of the reaction vessel 20 located at the first magnetic adsorption position 1001.
[0178] As an implementation manner, a first liquid adsorption position 1002 is formed between or on one side of the second magnetic members 120, that is: the second magnetic members 120 may be distributed in at least two directions of the first liquid adsorption position 1002 along the horizontal circumferential direction, or may be distributed on one side of the first liquid adsorption position 1002, as long as it is ensured that the magnetic field provided by the second magnetic members 120 for the first liquid adsorption position 1002 can adsorb and form at least one bead cluster 30 on the inner sidewall of the reaction vessel 20 located at the first liquid adsorption position 1002 and the number of bead clusters 30 adsorbed and formed at the first liquid adsorption position is less than the number of bead clusters 30 adsorbed and formed at the first magnetic adsorption position 1001.
[0179] As an implementation manner, the first magnetic member 110 includes two paired and spaced-apart first magnetic devices 111. A first magnetic adsorption position 1001 is formed on one side of each first magnetic device 111, that is: the first magnetic adsorption position 1001 is formed on only one side of each first magnetic device 111. Specifically, the first magnetic adsorption position 1001 is formed between the two paired and spaced-apart first magnetic devices 111 or the first magnetic adsorption position 1001 is formed on one side of the two paired and spaced-apart first magnetic devices 111. The first magnetic member 110 is configured to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic adsorption position 1001 to adsorb and form two magnetic bead clusters 30 on the inner sidewall of the reaction vessel 20 located at the first magnetic adsorption position 1001. The second magnetic member 120 is composed of a single second magnetic device 121. A first liquid adsorption position 1002 is formed on one side of the single second magnetic device 121. The second magnetic member 120 is configured to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid adsorption position 1002 to adsorb and form a single magnetic bead cluster 30 on the inner sidewall of the reaction vessel 20 located at the first liquid adsorption position 1002. The two paired and spaced-apart first magnetic devices 111 at the first magnetic adsorption position 1001 can adsorb magnetic beads and the target substances bound to the magnetic beads from different orientations, so that the distance of adsorption and movement of the magnetic beads and the target substances bound to the magnetic beads can be shortened, enabling the magnetic beads and the target substances bound to the magnetic beads to be quickly and proximally adsorbed to the inner sidewall of the reaction vessel 20, which is beneficial to ensuring the adsorption speed at the first magnetic adsorption position 1001. In addition, the single second magnetic device 121 at the first liquid adsorption position 1002 can adsorb and aggregate all the magnetic beads and the target substances bound to the magnetic beads in the reaction vessel 20 at the first liquid adsorption position 1002 into a single magnetic bead cluster 30, which is beneficial to increasing the stability of adsorption of the magnetic beads and the target substances bound to the magnetic beads during liquid absorption.In this embodiment, the first magnetic member 110 adsorbs and forms two bead clusters 30 on the inner sidewall of the reaction vessel 20 at the first magnetic adsorption position 1001, and the second magnetic member 120 adsorbs and forms a single bead cluster 30 on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002, meeting the design requirement that the number of bead clusters 30 formed by the first magnetic member 110 adsorbing on the inner sidewall of the reaction vessel 20 at the first magnetic adsorption position 1001 is greater than the number of bead clusters 30 formed by the second magnetic member 120 adsorbing on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002. Of course, in specific applications, the number of bead clusters 30 formed by the first magnetic member 110 adsorbing on the inner sidewall of the reaction vessel 20 at the first magnetic adsorption position 1001 and the number of bead clusters 30 formed by the second magnetic member 120 adsorbing on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002 are not limited to this. For example, as an alternative embodiment, it is also possible to adjust the design of the first magnetic member 110 and the second magnetic member 120 so that the first magnetic member 110 adsorbs and forms three or more bead clusters 30 on the inner sidewall of the reaction vessel 20 at the first magnetic adsorption position 1001, and the second magnetic member 120 adsorbs and forms a single bead cluster 30 or two bead clusters 30 on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002.
[0180] Refer to 3 and Figure 4 As shown in FIG. 3, as an implementation manner, the above two paired and spaced-apart first magnetic devices 111 are arranged at intervals in the horizontal direction on opposite sides of the first magnetic adsorption position 1001. In this embodiment, the first magnetic member 110 is distributed on the opposite sides of the first magnetic adsorption position 1001, that is, one first magnetic device 111 is arranged on one side of the first magnetic adsorption position 1001, and the other first magnetic device 111 is arranged on the other side of the first magnetic adsorption position 1001. In this way, the two paired and spaced-apart first magnetic devices 111 at the first magnetic adsorption position 1001 can adsorb magnetic beads and the target substances bound to the magnetic beads from opposite sides of the reaction vessel 20, so that the distance for the magnetic beads and the target substances bound to the magnetic beads to be adsorbed and moved can be better shortened, enabling the magnetic beads and the target substances bound to the magnetic beads to be quickly and proximally adsorbed to the inner sidewall of the reaction vessel 20, which is beneficial to ensuring the adsorption speed at the first magnetic adsorption position 1001. The second magnetic member 120 is distributed on one side of the first liquid adsorption position 1002, which is beneficial to ensuring the adsorption stability of the magnetic beads and the target substances bound to the magnetic beads in the reaction vessel 20 at the first liquid adsorption position 1002.
[0181] As an implementation manner, a receiving groove for receiving the reaction vessel 20 is provided at the first magnetic adsorption position 1001, and the two paired and spaced-apart first magnetic devices 111 are arranged at intervals and opposite to each other along the radial direction of the receiving groove, that is, the two paired and spaced-apart first magnetic devices 111 are distributed on opposite sides of the receiving groove.
[0182] As an implementation manner, the above two paired and spaced first magnetic devices 111 are spaced on opposite sides of the first magnetic attraction position 1001 along a diameter direction of the same reaction vessel 20. Two magnetic bead clusters 30 adsorbed and formed by the first magnetic member 110 on the inner sidewall of the reaction vessel 20 at the first magnetic attraction position 1001 are spaced along the diameter direction of the reaction vessel 20 and distributed on opposite sides of the reaction vessel 20.
[0183] As an implementation manner, the scheduling member 150 is configured to drive the bearing member 140 to drive the reaction vessel 20 to move to the first magnetic attraction position 1001 and the first liquid suction position 1002 in sequence; the two first magnetic devices 111 are respectively arranged on opposite sides of the movement track of the scheduling member 150 driving the reaction vessel 20 to move (the movement track described below, unless otherwise specified, refers to the movement track of the scheduling member 150 driving the reaction vessel 20 to move), and the second magnetic device 121 is arranged on one side of the movement track. In this implementation scheme, the scheduling mechanism drives the bearing member 140 to move, so that the bearing member 140 drives the reaction vessel 20 to move to the first magnetic attraction position 1001 and the first liquid suction position 1002 respectively. In this way, the scheduling member 150 does not need to perform the actions of clamping and releasing the reaction vessel 20, which is beneficial to simplifying the structure of the scheduling member 150 and improving the efficiency of the scheduling member 150 in scheduling the reaction vessel 20. Of course. In specific applications, as an alternative implementation scheme, the scheduling member 150 can also be designed to drive the reaction vessel 20 to move to the first magnetic attraction position 1001 and the first liquid suction position 1002 respectively by clamping and moving the reaction vessel 20. For example, the scheduling member 150 includes a jaw for clamping the reaction vessel 20 and a power member for driving the jaw to move.
[0184] As an implementation manner, the scheduling member 150 is configured to drive the bearing member 140 to drive the reaction vessel 20 loaded with the incubated liquid to move to the first magnetic attraction position 1001 and the first liquid suction position 1002 in sequence.
[0185] As an implementation manner, the carrier member 140 is disc-shaped, and a plurality of accommodating grooves are formed in the carrier member 140 and arranged along the circumferential direction of the disc-shaped carrier member 140. The circumferential direction of the disc-shaped carrier member 140 is horizontally arranged, and the plurality of accommodating grooves are arranged in the horizontal direction. Each accommodating groove is used to accommodate a reaction vessel 20, and the scheduling member 150 is used to drive the carrier member 140 to drive the reaction vessel 20 to horizontally rotate around the central axis of the carrier member 140, so that the reaction vessel 20 accommodated in the accommodating groove is sequentially scheduled to the first magnetic attraction position 1001 and the first liquid suction position 1002. The movement track of the scheduling member 150 driving the reaction vessel 20 is a circular track, and the first magnetic attraction position 1001 and the first liquid suction position 1002 are distributed along the circular movement track. Specifically, when the scheduling member 150 drives the carrier member 140 to rotate, the reaction vessel 20 on the carrier member 140 can sequentially pass through the first magnetic attraction position 1001 and the first liquid suction position 1002. Of course, in specific applications, the shape of the carrier member 140 is not limited to this, and the movement track of the scheduling member 150 driving the reaction vessel 20 is not limited to this. For example, as an alternative implementation manner, the movement track of the scheduling member 150 driving the reaction vessel 20 is a straight track, and the first magnetic attraction position 1001 and the first liquid suction position 1002 are distributed along the straight track; or, as another alternative implementation manner, the movement track of the scheduling member 150 driving the reaction vessel 20 is a bent line track, and the first magnetic attraction position 1001 and the first liquid suction position 1002 are distributed along the bent line track. As an implementation manner, the number of the first magnetic attraction positions 1001 is at least two, and the number of the first magnetic members 110 is at least two and the movement tracks are arranged in sequence, that is: the magnetic separation mechanism 100 includes at least two first magnetic members 110 arranged in sequence along the movement track, and each first magnetic member 110 correspondingly forms at least one first magnetic attraction position 1001. In this implementation manner, the number of the first magnetic attraction positions 1001 is at least two, so that the liquid in the reaction vessel 20 undergoes at least two stages of first magnetic adsorption actions before reaching the first liquid suction position 1002 to perform the first liquid suction action, which is beneficial to the parallel operation of a plurality of reaction vessels 20.
[0186] As an implementation manner, the number of the first liquid suction positions 1002 is at least two, and the number of the second magnetic members 120 is at least two and the movement tracks are arranged in sequence, that is: the magnetic separation mechanism 100 includes at least two second magnetic members 120 arranged in sequence along the movement track, and each second magnetic member 120 correspondingly forms at least one first liquid suction position 1002. In this implementation manner, the number of the first liquid suction positions 1002 is at least two, so that the liquid in the reaction vessel 20 undergoes at least two stages of first liquid suction actions in one magnetic separation operation, which is beneficial to ensuring the purification effect of the liquid in the reaction vessel 20.
[0187] Refer to 1 to Figure 3 、 Figure 6 andFigure 7 As shown, as an implementation manner, two paired and spaced first magnetic devices 111 are respectively disposed on opposite sides of the movement track. The magnetic separation mechanism 100 further includes a main bracket, a first mounting bracket 1061 and a second mounting bracket 1071, and the first mounting bracket 1061 and the second mounting bracket 1071 are respectively connected to the main bracket. The first mounting bracket and the second mounting bracket 1071 are respectively located on opposite sides of the movement track. The first mounting bracket 1061 is used to carry all the first magnetic devices 111 and all the second magnetic devices 121 disposed on one side of the movement track to form a first module 106, and the second mounting bracket 1071 is used to carry all the first magnetic devices 111 disposed on the other side of the movement track to form a second module 107. The first module 106 is connected to the main bracket through the first mounting bracket 1061, and the second module 107 is connected to the main bracket through the second mounting bracket 1071. In this implementation scheme, the magnetic devices on opposite sides of the movement track are designed and installed in modules, that is, all the magnetic devices on the same side of the movement track are installed on one mounting bracket as a module and installed on the main bracket together. In this way, it is beneficial to reduce the difficulty of installing the magnetic devices and the difficulty of later maintenance.
[0188] As an implementation manner, each first magnetic member 110 is composed of a first magnetic device 111 disposed on the first side of the movement track and a first magnetic device 111 disposed on the second side of the movement track, and each second magnetic member 120 is composed of a single second magnetic device 121 disposed on the first side, and the first side and the second side are respectively located on opposite sides of the movement track. The first mounting bracket 1061 is used to carry all the first magnetic devices 111 and all the second magnetic devices 121 disposed on the first side, and forms a first module 106 with all the first magnetic devices 111 and all the second magnetic devices 121 disposed on the first side. The second mounting bracket 1071 is used to carry all the first magnetic devices 111 disposed on the second side, and forms a second module 107 with all the first magnetic devices 111 disposed on the second side. The first module 106 is installed on the first side and is connected to the main bracket through the first mounting bracket 1061, and the second module 107 is installed on the second side and is connected to the main bracket through the second mounting bracket 1071.
[0189] As an implementation manner, the first magnetic device 111 is composed of at least two first magnets 1111. In this implementation scheme, the first magnetic device 111 is composed of at least two first magnets 1111, and each first magnet 1111 can form a magnetic field. By superimposing the magnetic fields of at least two first magnets 1111, it is beneficial to strengthen the magnetic attraction force, thereby being beneficial to improving the magnetic adsorption effect and efficiency.
[0190] As an implementation manner, the first magnetic device 111 is composed of at least two adjacent and paired first magnets 1111. One ends of two adjacent and paired first magnets 1111 that are close to the first magnetic attraction position 1001 are abutted against each other, or one sides of two adjacent and paired first magnets 1111 are in contact with each other.
[0191] As an implementation manner, at least two adjacent and paired first magnets 1111 of the same first magnetic device 111 are abutted against each other in sequence, that is: at least a part of any two adjacent first magnets 1111 in the same first magnetic device 111 are abutted against each other, so that the magnetic fields of two adjacent first magnets 1111 can be superimposed to enhance the magnetic attraction force. Of course, in specific applications, as an alternative implementation manner, there may also be a small distance, such as a distance less than 10 mm, between two adjacent first magnets 1111 of the same first magnetic device 111.
[0192] As an implementation manner, the first magnetic device 111 is composed of at least two adjacent and paired first magnets 1111, including: the first magnetic device 111 is composed of two first magnets 1111 with at least one end abutted against each other. The first magnetic device 111 is composed of two first magnets 1111 with at least one end abutted against each other, including any of the following situations: the first magnetic device 111 is composed of two first magnets 1111 stacked vertically (this also belongs to the situation where one sides of two adjacent and paired first magnets 1111 are in contact with each other), the first magnetic device 111 is composed of two first magnets 1111 abutted against each other along the horizontal circumferential direction, and the first magnetic device 111 is composed of two first magnets 1111 abutted against each other along the inclined direction. In this implementation manner, the number of first magnets 1111 constituting the first magnetic device 111 is two, which not only enhances the magnetic attraction force of the first magnetic device 111, but also helps to avoid the problem of increased cost caused by too many first magnets 1111. Of course, in specific applications, as an alternative implementation manner, the first magnetic device 111 may also be composed of three or more first magnets 1111 with at least one end abutted against each other.
[0193] As an implementation manner, the second magnetic device 121 is composed of at least two second magnets 1211. In this implementation manner, the second magnetic device 121 is composed of at least two second magnets 1211, and each second magnet 1211 can form a magnetic field. By superimposing the magnetic fields of at least two second magnets 1211, it is beneficial to enhance the magnetic attraction force, thereby improving the magnetic adsorption effect and efficiency.
[0194] As an implementation manner, the second magnetic device 121 is composed of at least two adjacent and paired second magnets 1211. One ends of two adjacent and paired second magnets 1211 close to the first liquid suction position 1002 are abutted against each other, or one sides of two adjacent and paired second magnets 1211 are in contact with each other.
[0195] As an implementation manner, at least two adjacent and paired second magnets 1211 of the same second magnetic device 121 are abutted in sequence, that is: at least partially, any two adjacent second magnets 1211 in the same second magnetic device 121 are abutted against each other, so that the magnetic fields of two adjacent second magnets 1211 can be superimposed to enhance the magnetic suction force. Of course, in specific applications, as an alternative implementation manner, there may also be a small distance, such as a distance less than 10 mm, between two adjacent second magnets 1211 of the same second magnetic device 121.
[0196] As an implementation manner, the second magnetic device 121 is composed of at least two adjacent and paired second magnets 1211 includes: the second magnetic device 121 is composed of two second magnets 1211 with at least one end abutted against each other. The second magnetic device 121 is composed of two second magnets 1211 with at least one end abutted against each other includes any of the following situations: the second magnetic device 121 is composed of two second magnets 1211 stacked in the vertical direction (this also belongs to the situation where one sides of two adjacent and paired second magnets 1211 are in contact with each other), the second magnetic device 121 is composed of two second magnets 1211 abutted against each other in the horizontal circumferential direction, and the second magnetic device 121 is composed of two second magnets 1211 abutted against each other in the inclined direction. In this implementation manner, the number of second magnets 1211 constituting the second magnetic device 121 is two, which not only enhances the magnetic suction force of the second magnetic device 121, but also helps to avoid the problem of increased cost caused by too many second magnets 1211. Of course, in specific applications, as an alternative implementation manner, the second magnetic device 121 may also be composed of three or more second magnets 1211 with at least one end abutted against each other, as long as it is ensured that the number of magnetic bead clusters 30 adsorbed by the second magnetic member 120 on the inner side wall of a reaction vessel 20 located at the first liquid suction position 1002 is less than the number of magnetic bead clusters 30 adsorbed by the first magnetic member 110 on the inner side wall of a reaction vessel 20 located at the first magnetic suction position 1001.
[0197] Refer to Figures 4 to 6As shown, as an implementation manner, the first magnetic device 111 is composed of two first magnets 1111 stacked vertically. The second magnetic device 121 is composed of two second magnets 1211 stacked vertically. With this setting scheme, on the premise of enhancing the magnetic attraction force between the first magnetic device 111 and the second magnetic device 121, it is also beneficial to reduce the horizontal space occupied by the first magnetic device 111 and the second magnetic device 121.
[0198] As an implementation manner, the first magnet 1111 forms two magnetic poles, namely the N pole and the S pole. The two magnetic poles of the first magnet 1111 are respectively located at opposite ends of the first magnet 1111. The second magnet 1211 forms two magnetic poles, namely the N pole and the S pole. The two magnetic poles of the second magnet 1211 are respectively located at opposite ends of the second magnet 1211.
[0199] As an implementation manner, the two magnetic poles of the same first magnet 1111 are arranged horizontally, that is, the N pole and the S pole of the same first magnet 1111 are horizontally placed, and the N pole is on the left or right or front or back of the S pole. One magnetic pole of the first magnet 1111 faces the first magnetic attraction position 1001, and the other magnetic pole extends horizontally away from the first magnetic attraction position 1001. For example, the first magnet 1111 is arranged with the N pole facing the first magnetic attraction position 1001 and the S pole facing away from the first magnetic attraction position 1001 horizontally; or, the first magnet 1111 is arranged with the S pole facing the first magnetic attraction position 1001 and the N pole facing away from the first magnetic attraction position 1001 horizontally. Of course, in specific applications, the two magnetic poles of the first magnet 1111 are not limited to being horizontally arranged. For example, as an alternative implementation scheme, the two magnetic poles of the same first magnet 1111 are arranged vertically, that is, the N pole and the S pole of the same first magnet 1111 are vertically placed, and the N pole is above or below the S pole; or, as another alternative implementation scheme, the two magnetic poles of the same first magnet 1111 are arranged obliquely, that is, the N pole and the S pole of the same first magnet 1111 are placed in an oblique straight line, and the N pole is diagonally above or below the S pole.
[0200] As an implementation manner, the two magnetic poles of the same second magnet 1211 are arranged in the horizontal direction, that is, the N pole and the S pole of the same second magnet 1211 are horizontally placed, and the N pole is on the left or right or front or back side of the S pole. Of course, in specific applications, the two magnetic poles of the second magnet 1211 are not limited to being horizontally arranged. For example, as an alternative implementation manner, the two magnetic poles of the same second magnet 1211 are arranged in the vertical direction, that is, the N pole and the S pole of the same second magnet 1211 are vertically placed, and the N pole is above or below the S pole; or, as another alternative implementation manner, the two magnetic poles of the same second magnet 1211 are arranged in the inclined direction, that is, the N pole and the S pole of the same second magnet 1211 are placed in an inclined straight line, and the N pole is diagonally above or diagonally below the S pole.
[0201] As an implementation manner, the polarities of the magnetic poles of the two first magnets 1111 stacked in the vertical direction in the same first magnetic device 111 facing the same first magnetic attraction position 1001 are opposite, and the polarities of the magnetic poles of the two second magnets 1211 stacked in the vertical direction in the same second magnetic device 121 facing the same first liquid suction position 1002 are opposite. For example, one first magnet 1111 in the same first magnetic device 111 faces the first magnetic attraction position 1001 with the N pole, and the other first magnet 1111 faces the first magnetic attraction position 1001 with the S pole. One second magnet 1211 in the same second magnetic device 121 faces the first liquid suction position 1002 with the N pole, and the other second magnet 1211 faces the first liquid suction position 1002 with the S pole. In this way, the principle of attraction between opposite sexes can be used to facilitate the installation of the first magnetic device 111 and the second magnetic device 121. Of course, in specific applications, as an alternative implementation manner, the polarities of the magnetic poles of the two first magnets 1111 stacked in the vertical direction in the same first magnetic device 111 facing the same first magnetic attraction position 1001 can also be set to be the same, and the polarities of the magnetic poles of the two second magnets 1211 stacked in the vertical direction in the same second magnetic device 121 facing the same first liquid suction position 1002 can be set to be the same. In order to prevent the two first magnets 1111 from repelling and shifting, and the two second magnets 1211 from repelling and shifting, other limiting structural members can be added to limit the two first magnets 1111 and the second magnets 1211.
[0202] As an implementation manner, among two paired and spaced-apart first magnetic devices 111 of the same first magnetic component 110, the polarities of the two first magnets 1111 distributed on opposite sides of the same first magnetic attraction position 1001 and at the same height position and facing the same first magnetic attraction position 1001 are the same, that is: among two paired and spaced-apart first magnetic devices 111, the polarities of the two first magnets 1111 distributed on the same layer and facing the same first magnetic attraction position 1001 are the same. In this way, it is beneficial to better shorten the distance for the magnetic beads and the target substances combined with the magnetic beads to be adsorbed and moved, and further beneficial to further improve the adsorption speed.
[0203] Refer to 3 and Figure 4As shown, as an implementation manner, two paired and spaced-apart first magnetic devices 111 are horizontally spaced apart on opposite sides of the first magnetic attraction position 1001, and a single second magnetic device 121 is disposed on one side of the first magnetic attraction position 1002. The first magnetic device 111 is composed of two first magnets 1111 stacked vertically, and the second magnetic device 121 is composed of two second magnets 1211 stacked vertically; the two magnetic poles of the same first magnet 1111 are arranged horizontally, and the two magnetic poles of the same second magnet 1211 are arranged horizontally; the polarities of the magnetic poles of the two first magnets 1111 stacked vertically in the same first magnetic device 111 facing the same first magnetic attraction position 1001 are opposite, and the polarities of the magnetic poles of the two second magnets 1211 stacked vertically in the same second magnetic device 121 facing the same first magnetic attraction position 1002 are opposite; in the two paired and spaced-apart first magnetic devices 111 of the same first magnetic component 110, the polarities of the magnetic poles of the two first magnets 1111 distributed on opposite sides of the same first magnetic attraction position 1001 and at the same height position facing the same first magnetic attraction position 1001 are the same. The contact between the two first magnets 1111 is such that the two magnetic poles of one first magnet 1111 respectively contact the two magnetic poles of the other first magnet 1111 in a manner with opposite polarities, and the contact between the two second magnets 1211 is such that the two magnetic poles of one second magnet 1211 respectively contact the two magnetic poles of the other second magnet 1211 in a manner with opposite polarities. For example: the N pole of the upper first magnet 1111 contacts the S pole of the lower first magnet 1111, and the N pole of the upper second magnet 1211 contacts the S pole of the lower second magnet 1211. At this time, one side of the two first magnets 1111 contacts each other (i.e., the upper side of one first magnet 1111 contacts the lower side of the other first magnet 1111), and one side of the two second magnets 1211 contacts each other (i.e., the upper side of one second magnet 1211 contacts the lower side of the other second magnet 1211). By adopting this setting method, the rapid adsorption requirement of the first magnetic attraction position 1001 and the stable adsorption requirement of the first magnetic attraction position 1002 can be taken into account at a very low cost.
[0204] As an implementation manner, the height position of the first magnetic member 110 is lower than the height position of the second magnetic member 120. In this way, the distance between the magnetic bead cluster 30 adsorbed and formed by the second magnetic member 120 at the first liquid suction level 1002 and the bottom of the reaction vessel 20 can be increased, so that the magnetic bead cluster 30 adsorbed and formed at the first liquid suction level 1002 is far away from the bottom of the reaction vessel 20, which is more conducive to preventing the adverse phenomenon that the magnetic bead cluster 30 falls off and is sucked away by the first liquid suction member 130 when the first liquid suction member 130 sucks liquid. Of course, in specific applications, as an alternative implementation manner, the height position of the first magnetic member 110 and the height position of the second magnetic member 120 can also be set to be the same.
[0205] As an implementation manner, at least two first magnetic suction positions 1001 are formed on one side of each first magnetic device 111 and are distributed in sequence along the movement track of the scheduling member 150 driving the reaction vessel 20 to move. A first magnetic member 110 is used to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at at least two first magnetic suction positions 1001 to respectively adsorb and form two magnetic bead clusters 30 on the inner side walls of the reaction vessels 20 located at at least two first magnetic suction positions 1001. The scheduling member 150 is used to drive the bearing member 140 to drive the reaction vessel 20 loaded with the incubated liquid to move along a preset track to at least two first magnetic suction positions 1001 in sequence. In this implementation manner, the same first magnetic member 110 provides a magnetic field at at least two first magnetic suction positions 1001, which is conducive to reducing the number of first magnetic members 110, thereby facilitating the reduction of the installation difficulty of the first magnetic member 110. Of course, in specific applications, as an alternative implementation manner, only one first magnetic suction position 1001 can also be formed on one side of each first magnetic device 111.
[0206] As an implementation manner, at least two first magnetic suction positions 1001 distributed in sequence along the movement track of the scheduling member 150 driving the reaction vessel 20 to move are arranged between two paired and spaced-apart first magnetic devices 111, that is: at least two first magnetic suction positions 1001 distributed in sequence along the movement track of the scheduling member 150 driving the reaction vessel 20 to move are formed between two paired and spaced-apart first magnetic devices 111. Of course, in specific applications, as an alternative implementation manner, only one first magnetic suction position 1001 can also be formed between two paired and spaced-apart first magnetic devices 111.
[0207] As an implementation manner, at least two first liquid suction positions 1002 are formed on one side of a single second magnetic device 121, which are sequentially distributed along the movement track of the scheduling member 150 driving the reaction vessel 20 to move. A second magnetic member 120 is used to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at at least two first liquid suction positions 1002 to respectively adsorb and form a single magnetic bead group 30 on the inner side walls of the reaction vessels 20 located at at least two first liquid suction positions 1002. The scheduling member 150 is used to drive the carrying member 140 to drive the reaction vessel 20 loaded with the liquid after the first magnetic adsorption action to be sequentially scheduled to at least two first liquid suction positions 1002 along a preset track. In this implementation scheme, the same second magnetic member 120 provides a magnetic field at at least two first liquid suction positions 1002, which is beneficial to reducing the number of second magnetic members 120, thereby facilitating the reduction of the installation difficulty of the second magnetic member 120. Of course, in specific applications, as an alternative implementation scheme, only one first liquid suction position 1002 may also be formed on one side of a single second magnetic device 121.
[0208] Refer to FIGS. 1 to Figure 3 As shown, as an implementation manner, the magnetic separation mechanism 100 further includes at least one third magnetic member 160, and the third magnetic member 160 is composed of a single third magnetic device 161. A second magnetic suction position 1003 is formed on one side of the single third magnetic device 161. The third magnetic member 160 is used to perform a third magnetic adsorption action on the liquid in the reaction vessel 20 located at the second magnetic suction position 1003 to adsorb and form a single magnetic bead group 30 on the inner side wall of the reaction vessel 20 located at the second magnetic suction position 1003. The above-mentioned scheduling member 150 schedules the reaction vessel 20 after the first magnetic adsorption action to the first liquid suction position 1002, including: first scheduling the reaction vessel 20 after the first magnetic adsorption action to the second magnetic suction position 1003, and then scheduling the reaction vessel 20 after the third magnetic adsorption action to the first liquid suction position 1002. In this implementation scheme, after two magnetic bead groups 30 are quickly adsorbed and formed at the first magnetic suction position 1001 by the first magnetic member 110, first, the two magnetic bead groups 30 are adsorbed and aggregated to form a single magnetic bead group 30 at the second magnetic suction position 1003 by the third magnetic member 160, so that after a single magnetic bead group 30 is firmly adsorbed, magnetic adsorption and liquid suction are performed at the first liquid suction position 1002, thereby further ensuring the firm adsorption of the magnetic bead group 30 during liquid suction.
[0209] As an implementation manner, the first magnetic suction position 1001, the second magnetic suction position 1003, and the first liquid suction position 1002 are sequentially distributed along the movement track of the scheduling member 150 driving the reaction vessel 20 to move. In this implementation scheme, the second magnetic suction position 1003 is arranged between the first magnetic suction position 1001 and the first liquid suction position 1002 along an arc track.
[0210] As an embodiment, the third magnetic device 161 is arranged on one side of the motion trajectory of the reaction container 20 driven by the scheduling component 150, and the second magnetic device 121 is also arranged on this side of the motion trajectory, that is, all the third magnetic devices 161 and all the second magnetic devices 121 are arranged on the same side of the motion trajectory of the reaction container 20 driven by the scheduling component 150. In this way, the reaction container 20 can move from the second magnetic suction position 1003 to the first liquid suction position 1002 without changing the direction to adsorb the magnetic bead group 30.
[0211] As an embodiment, each third magnetic component 160 is composed of a single third magnetic device 161 arranged on the first side, and the first mounting frame 1061 is used to support all the first magnetic devices 111, all the second magnetic devices 121 and all the third magnetic devices 161 arranged on the first side, and form a first module 106 together with all the first magnetic devices 111, all the second magnetic devices 121 and all the third magnetic devices 161 arranged on the first side.
[0212] As an implementation mode, the third magnetic device 161 is composed of one or at least two third magnets. In addition to the different arrangement positions of the third magnetic device 161 and the second magnetic device 121, the third magnetic device 161 can be constructed in the same arrangement as the second magnetic device 121. For example, the number, distribution, and polarity orientation of the third magnets in the third magnetic device 161 can refer to the number, distribution, and polarity orientation of the second magnets 1211 in the second magnetic device 121, which will not be described in detail here.
[0213] As an embodiment, the first liquid suction component 130 includes a first liquid suction needle and a first liquid suction power component for driving the first liquid suction needle to perform liquid suction.
[0214] Refer to 1 to Figure 3 , Figure 8 and Figure 9As shown, as an implementation manner, the magnetic separation mechanism 100 further includes at least one first liquid injection member, at least one mixing member 180, at least one fourth magnetic member 190, at least one fifth magnetic member 101, and at least one second liquid suction member 102. The fourth magnetic member 190 includes two paired and spaced-apart fourth magnetic devices 191. On one side of each fourth magnetic device 191 (including between the two paired and spaced-apart fourth magnetic devices 191, or on one side of the two paired and spaced-apart fourth magnetic devices 191), a third magnetic attraction position 1004 is formed. The fourth magnetic member 190 is configured to perform a fourth magnetic adsorption action on the liquid in the reaction vessel 20 located at the third magnetic attraction position 1004 to adsorb and form two magnetic bead clusters 30 on the inner sidewall of the reaction vessel 20 located at the third magnetic attraction position 1004. The fifth magnetic member 101 is composed of a single fifth magnetic device 1011. On one side of the single fifth magnetic device 1011, a second liquid suction position 1005 is formed. The fifth magnetic member 101 is configured to perform a fifth magnetic adsorption action on the liquid in the reaction vessel 20 located at the second liquid suction position 1005 to adsorb and form a single magnetic bead cluster 30 on the inner sidewall of the reaction vessel 20 located at the second liquid suction position 1005. The second liquid suction member 102 is configured to perform a second liquid suction action on the liquid in the reaction vessel 20 located at the second liquid suction position 1005. The scheduling member 150 is further configured to sequentially schedule the reaction vessel 20 after the first liquid suction action to the first liquid injection position 1006, the mixing position 1007, the third magnetic attraction position 1004, and the second liquid suction position 1005. The carrying member 140 is further configured to carry the reaction vessel 20 located at the first liquid injection position 1006, carry the reaction vessel 20 located at the mixing position 1007, carry the reaction vessel 20 located at the third magnetic attraction position 1004, and carry the reaction vessel 20 located at the second liquid suction position 1005. The first liquid injection member is configured to perform a first liquid injection action of injecting a cleaning liquid on the reaction vessel 20 located at the first liquid injection position 1006 and having completed the first liquid suction action. The mixing member 180 is configured to perform a mixing action on the reaction vessel 20 located at the mixing position 1007 and having completed the first liquid injection action. The cleaning liquid injected by the first liquid injection member is mainly used to clean the magnetic bead clusters 30 adsorbed previously. The mixing member 180 is configured to disperse the magnetic bead clusters 30 so that the cleaning liquid can fully contact the magnetic bead clusters 30 to wash out other impurities in the magnetic bead clusters 30, thereby facilitating further improvement of the purification effect of the liquid in the reaction vessel 20.
[0215] As an implementation manner, the setting principle and structure of the fourth magnetic member 190 are similar to those of the first magnetic member 110. The third magnetic attraction position 1004 and the first magnetic attraction position 1001 are equivalent to performing two-stage similar magnetic adsorption actions. The setting principle and structure of the fourth magnetic member 190 can refer to the first magnetic member 110 and will not be elaborated herein.
[0216] As an implementation manner, the setting principle and structure of the fifth magnetic member 101 are similar to those of the second magnetic member 120, and the setting principle and structure of the second liquid absorption member 102 are similar to those of the first liquid absorption member 130. The second liquid absorption level 1005 formed on one side of a single fifth magnetic device 1011 and the first liquid absorption level 1002 formed on one side of a single second magnetic device 121 are equivalent to performing two-order similar magnetic adsorption actions and two-order similar liquid absorption actions. The setting principle and structure of the fifth magnetic member 101 can be referred to that of the second magnetic member 120, and will not be elaborated here. The setting principle and structure of the second liquid absorption member 102 can be referred to that of the first liquid absorption member 130, and will not be elaborated here.
[0217] As an implementation manner, the third magnetic attraction position 1004 and the first magnetic attraction position 1001 are located at two different positions, the second liquid absorption level 1005 and the first liquid absorption level 1002 are located at two different positions, the fourth magnetic member 190 and the first magnetic member 110 are two magnetic members with the same structural principle and can work in parallel with each other, the fifth magnetic member 101 and the second magnetic member 120 are two magnetic members with the same structural principle and can work in parallel with each other, and the second liquid absorption member 102 and the first liquid absorption member 130 are two liquid absorption members with the same structural principle and can work in parallel with each other. Of course, in specific applications, as an alternative implementation, the third magnetic attraction position 1004 and the first magnetic attraction position 1001 can also be set at the same position, and the second liquid absorption level 1005 and the first liquid absorption level 1002 can be set at the same position. In this alternative implementation, the fourth magnetic member 190 and the first magnetic member 110 are the same magnetic member, the fifth magnetic member 101 and the second magnetic member 120 are the same magnetic member, and the second liquid absorption member 102 and the first liquid absorption member 130 are the same liquid absorption member.
[0218] As an implementation manner, the first liquid injection level 1006 and the first liquid absorption level 1002 are located at two different positions, and the first liquid injection level 1006 is mainly used to perform the liquid injection action before the mixing action. Of course, in specific applications, as an alternative implementation, the first liquid injection level 1006 and the first liquid absorption level 1002 can also be set at the same position.
[0219] As an implementation manner, the first liquid injection member includes a first liquid injection needle and a liquid injection power member for driving the first liquid injection needle to perform the liquid injection action.
[0220] Refer to 1 to Figure 3As shown, as an implementation, the magnetic separation mechanism 100 further includes at least one sixth magnetic member 103. The sixth magnetic member 103 is composed of a single sixth magnetic device 1031. A fourth magnetic attraction position 1008 is formed on one side of the single sixth magnetic device 1031. The sixth magnetic member 103 is configured to perform a sixth magnetic adsorption action on the liquid in the reaction vessel 20 located at the fourth magnetic attraction position 1008 to form a single magnetic bead cluster 30 adsorbed on the inner sidewall of the reaction vessel 20 located at the fourth magnetic attraction position 1008. The carrier member 140 is further configured to carry the reaction vessel 20 located at the fourth magnetic attraction position 1008. The scheduling member 150 schedules the reaction vessel 20 that has completed the fourth magnetic adsorption action at the third magnetic attraction position 1004 to the second liquid suction position 1005, including: first scheduling the reaction vessel 20 that has completed the fourth magnetic adsorption action at the third magnetic attraction position 1004 to the fourth magnetic attraction position 1008, and then scheduling the reaction vessel 20 that has completed the sixth magnetic adsorption action at the fourth magnetic attraction position 1008 to the second liquid suction position 1005. The setting principle and structure of the sixth magnetic member 103 are similar to those of the third magnetic member 160. The fourth magnetic attraction position 1008 formed on one side of the single sixth magnetic device 1031 and the second magnetic attraction position 1003 formed on one side of the single third magnetic device 161 are equivalent to performing two-order similar magnetic adsorption actions. The setting principle and structure of the sixth magnetic member 103 can refer to the third magnetic member 160 and will not be elaborated here.
[0221] As an implementation manner, the magnetic separation mechanism 100 further includes at least one seventh magnetic member 104, at least one second liquid injection member, and at least one third liquid absorption member 109. The seventh magnetic member 104 is composed of a single seventh magnetic device 1041. A third liquid absorption level 1009 is formed on one side of the single seventh magnetic device 1041. The seventh magnetic member 104 is used to perform a seventh magnetic adsorption action on the liquid in the reaction vessel 20 at the third liquid absorption level 1009 to adsorb and form a single magnetic bead group 30 on the inner side wall of the reaction vessel 20 at the third liquid absorption level 1009. The scheduling member 150 is further used to sequentially schedule the reaction vessel 20 after the second liquid absorption action to the second liquid injection level and the third liquid absorption level 1009. The carrying member 140 is further used to carry the reaction vessel 20 at the second liquid injection level and carry the reaction vessel 20 at the third liquid absorption level 1009. The second liquid injection member is used to perform a second liquid injection action of injecting a cleaning liquid on the reaction vessel 20 at the second liquid injection level and after the second liquid absorption action. The third liquid absorption member 109 is used to perform a third liquid absorption action on the liquid in the reaction vessel 20 at the third liquid absorption level 1009. The setting principle and structure of the seventh magnetic member 104 are similar to the setting principle and structure of the fifth magnetic member 101 and the setting principle and structure of the second magnetic member 120. The third liquid absorption level 1009 formed on one side of the single seventh magnetic device 1041, the second liquid absorption level 1005 formed on one side of the single fifth magnetic device 1011, and the first liquid absorption level 1002 formed on one side of the single second magnetic device 121 are equivalent to performing third-order similar liquid absorption actions. The setting principle and structure of the seventh magnetic member 104 can refer to the fifth magnetic member 101 and the second magnetic member 120. The setting principle and structure of the third liquid absorption member 109 can refer to the second liquid absorption member 102 and the first liquid absorption member 130, and will not be elaborated here.
[0222] As an implementation manner, the second liquid injection level and the third liquid absorption level 1009 are located at two different positions; of course, in specific applications, as an alternative implementation, the second liquid injection level and the third liquid absorption level 1009 can also be located at the same position.
[0223] As an implementation manner, the second liquid injection level and the second liquid absorption level 1005 are located at the same position. Of course, in specific applications, as an alternative implementation, the second liquid injection level and the second liquid absorption level 1005 can also be located at two different positions.
[0224] Refer to Figures 1 to Figure 3 and Figure 7 As shown in Figures 1 to
[0225] As an embodiment, the third liquid injection component 170 is used to perform a third liquid injection action of injecting cleaning liquid into the reaction container 20 that is located at the first liquid suction position 1002 and has completed the first liquid suction action.
[0226] Refer to 1 to Figure 3 As shown, as an embodiment, the magnetic separation mechanism 100 also includes at least one fourth liquid absorption component and at least one eighth magnetic component 105, the eighth magnetic component 105 is composed of a single eighth magnetic device 1051, and a fourth liquid absorption position 1092 is formed on one side of the single seventh magnetic device 1041, and the fourth liquid absorption position 1092 is arranged between the first liquid absorption position 1002 and the first liquid injection position 1006. The eighth magnetic component 105 is used to perform an eighth magnetic adsorption action on the liquid in the reaction container 20 located at the fourth liquid absorption position 1092 to adsorb the inner wall of the reaction container 20 located at the fourth liquid absorption position 1092 to form a single magnetic bead group 30, and the fourth liquid absorption component is used to perform a fourth liquid absorption action on the reaction container 20 located at the fourth liquid absorption position 1092 and after completing the third liquid injection action.
[0227] As an embodiment, the magnetic separation mechanism 100 further includes at least one fourth liquid injection component, and the fourth liquid injection component is used to perform a fourth liquid injection action of injecting a cleaning liquid into the reaction container 20 after completing a second liquid aspiration action.
[0228] As an embodiment, the fourth liquid injection component is used to perform a fourth liquid injection action of injecting cleaning liquid into the reaction container 20 that is located at the second liquid suction position 1005 and has completed the second liquid suction action.
[0229] Refer to 1 to Figure 3 As shown, as an embodiment, the magnetic separation mechanism 100 further includes at least one fifth liquid injection component 108, and the fifth liquid injection component 108 is used to perform a fifth liquid injection action on the reaction container 20 at the first magnetic attraction position. Of course, in a specific application, the fifth liquid injection component 108 may not be provided.
[0230] Refer to 1 to Figure 3 , Figure 8 and Figure 9As shown, as an implementation manner, the carrier member 140 includes a plurality of support members 141. The plurality of support members 141 are spaced apart along the movement trajectory, and each support member 141 can independently rotate around the vertical axis; each support member 141 is respectively used to support the bottom of a reaction vessel 20; the mixing member 180 includes a pressing member 181, a rotation driving member 182, and a lifting driving member 183. The pressing member 181 is disposed above the mixing position 1007 in a liftable manner to press against the top of the reaction vessel 20 at the mixing position 1007; the lifting driving member 183 is used to: drive the rotation driving member 182 and the pressing member 181 to move up and down, so that the pressing member 181 presses against the reaction vessel 20 or disengages from the reaction vessel 20; the rotation driving member 182 is used to: when the pressing member 181 presses against the top of the reaction vessel 20 at the mixing position 1007, drive the pressing member 181 to drive the reaction vessel 20 at the mixing position 1007 to rotate, so as to mix the liquid in the reaction vessel 20.
[0231] Refer to 1 to Figure 3 As shown, as an implementation manner, the sample analyzer 10 further includes a substrate dispensing mechanism 500. The reagent dispensing mechanism 700 is further used to aspirate the second reagent from the second reagent container and dispense it into the reaction vessel 20. The second reagent contains an enzyme; the incubation mechanism 400 is used to incubate the liquid in the reaction vessel 20 that at least contains a sample, a first reagent, and a second reagent; the substrate dispensing mechanism 500 is used to dispense a substrate into the reaction vessel 20 after the magnetic separation operation is completed to prepare a test solution.
[0232] As an implementation manner, the magnetic separation mechanism 100 is used to perform magnetic separation cleaning on the liquid in the reaction vessel 20, so that the liquid in the reaction vessel 20 is separated into a magnetic bead liquid and a supernatant. The supernatant is treated as waste liquid, and the magnetic bead liquid is used to prepare a test solution for subsequent measurement.
[0233] Refer to 1 to Figure 3 As shown, as an implementation manner, 36 accommodation grooves are formed on the carrier member 140, and the magnetic separation mechanism 100 correspondingly forms 36 work positions. Each time the carrier member 140 rotates one cycle, it advances one work position. The 36 work positions are connected end to end in a ring shape, that is, both sides of the first work position are adjacent to the second work position and the thirty-sixth work position respectively.
[0234] Among them, the first work position is the pick-and-place position 1094, which is used for the manipulator to perform the operations of picking and placing the reaction vessel 20 on the carrier member 140.
[0235] Both the second work position and the third work position are avoidance positions 1091 to avoid interference between the manipulator and the fifth liquid injection member 108.
[0236] The fourth station to the tenth station are respectively the sixth-order first magnetic adsorption positions 1001, which are used to adsorb from both sides of the reaction vessel 20 to form two magnetic bead clusters 30. The first-order first magnetic adsorption position 1001 can also be used to perform the fifth liquid injection action to supplement the liquid in the reaction vessel 20 to a sufficient amount.
[0237] The eleventh station to the fourteenth station are respectively the fourth-order second magnetic adsorption positions 1003, which are used to adsorb from one side of the reaction vessel 20 to form a single magnetic bead cluster 30.
[0238] The fifteenth station to the sixteenth station are respectively the second-order first liquid suction positions 1002, and each first liquid suction position 1002 is used to perform one liquid suction action and one liquid injection action.
[0239] The seventeenth station is the first-order fourth liquid suction position 1092, and the fourth liquid suction position 1092 is used to perform two liquid suction actions.
[0240] The eighteenth station is the first-order first liquid injection position 1006, and the first liquid suction position 1002 is used to perform one liquid injection action.
[0241] The nineteenth station to the twenty-first station are respectively the third-order mixing positions 1007, which are used to perform a mixing action on the liquid in the reaction vessel 20.
[0242] The twenty-second station to the twenty-seventh station are respectively the sixth-order third magnetic adsorption positions 1004, which are used to adsorb from both sides of the reaction vessel 20 to form two magnetic bead clusters 30.
[0243] The twenty-eighth station to the thirty-first station are respectively the fourth-order fourth magnetic adsorption positions 1008, which are used to adsorb from one side of the reaction vessel 20 to form a single magnetic bead cluster 30.
[0244] The thirty-second station to the thirty-third station are respectively the second-order second liquid suction positions 1005, and each second liquid suction position 1005 is used to perform one liquid suction action and one liquid injection action.
[0245] The thirty-fourth station is the first-order third liquid suction position 1009, and the third liquid suction position 1009 is used to perform two liquid suction actions.
[0246] The thirty-fifth station is the first-order substrate distribution position 1093, and the substrate distribution position 1093 is used to perform an action of injecting a substrate.
[0247] The thirty-sixth station is the avoidance position 1091 to avoid interference between the manipulator and the substrate distribution mechanism 500.
[0248] Of course, in specific applications, the number of accommodation grooves formed on the bearing member 140, the number of stations, and the station actions are not limited to the above solutions, and the number of stations can also be set to more than 36 or less than 36.
[0249] Referring to 1 and Figure 2 As shown, as an implementation manner, the sample analyzer 10 further includes a sample dispensing mechanism 600. The sample dispensing mechanism 600 is configured to aspirate a sample from a sample container and dispense it into the reaction container 20. The sample container is used to load the sample collected from the patient for sampling. It should be noted that the reaction container 20 for the sample dispensing operation of the sample dispensing mechanism 600 and the reaction container 20 for incubating the sample with the first reagent can be the same reaction container 20 or two independent reaction containers 20. In this implementation, the sample dispensing mechanism 600 is used to aspirate the sample from the sample container and dispense it into the reaction container 20 to achieve the automatic dispensing function of the sample, which is conducive to achieving accurate quantification of the sample, and enabling the sample in one sample container to be dispensed into different reaction containers 20 for different measurement items. Of course, in specific applications, as an alternative implementation, the dispensing operation of the sample can also be performed manually and then placed into the sample analyzer 10 for incubation, magnetic separation, and measurement.
[0250] As an implementation manner, the sample dispensing mechanism 600 includes a sample needle, a first suction and discharge power component, and a first movement power component. Among them, the first suction and discharge power component is connected to the sample needle through a pipeline to drive the sample needle to perform suction and discharge actions, thereby realizing the function of the sample needle to aspirate and discharge samples. The first movement power component is used to drive the sample needle to perform two-dimensional or three-dimensional spatial movement to drive the sample needle to move to different workstations respectively, such as the sample aspiration position, the sample addition position, the cleaning position, the standby position of the sample needle, etc.
[0251] Referring to 1 and Figure 2 As shown, as an implementation manner, the sample analyzer 10 further includes a reagent dispensing mechanism 700. The reagent dispensing mechanism 700 is at least configured to aspirate the first reagent from the first reagent container and dispense it into the reaction container 20. The first reagent container is used to load the first reagent. In this implementation, the reagent dispensing mechanism 700 is used to aspirate the first reagent from the first reagent container and dispense it into the reaction container 20, which is conducive to realizing the automatic dispensing and accurate quantification of the first reagent. Of course, in specific applications, as an alternative implementation, the dispensing operation of the first reagent can also be pre-stored in the reaction container 20 or performed manually and then placed into the sample analyzer 10 for incubation, magnetic separation, and measurement.
[0252] As an implementation manner, the reagent dispensing mechanism 700 is further configured to aspirate the second reagent from the second reagent container and dispense it into the reaction container 20.
[0253] As an implementation manner, the reagent dispensing mechanism 700 includes a reagent needle, a second suction and discharge power assembly, and a second movement power assembly. Among them, the second suction and discharge power assembly is connected to the reagent needle through a pipeline to drive the reagent needle to perform suction and discharge actions, so as to realize the functions of sucking and discharging reagents by the reagent needle. The second movement power assembly is used to drive the reagent needle to perform two-dimensional or three-dimensional space movement, so as to drive the reagent needle to move to different stations respectively, such as the reagent suction station, the reagent addition station, the cleaning station, the standby station of the reagent needle, etc.
[0254] Referring to FIG. 1, as an implementation manner, the sample analyzer 10 further includes a reagent storage mechanism 800. The reagent storage mechanism 800 is used to store the first reagent container, and the reagent dispensing mechanism 700 sucks the reagent from the reagent container in the reagent storage mechanism 800. Of course, in specific applications, as an alternative implementation, the reagent storage mechanism 800 may not be provided in the sample analyzer 10. For example, the operator places the first reagent container at the reagent suction station.
[0255] As an implementation manner, the reagent storage mechanism 800 is further used to store the second reagent container. As an implementation manner, the reagent storage mechanism 800 is in a disk shape, and the reagent storage mechanism 800 is formed with a plurality of reagent positions distributed along the circumferential direction, and each reagent position is used to accommodate a reagent container. Of course, in specific applications, the shape of the reagent storage mechanism 800 is not limited to this.
[0256] Referring to FIG. 1, as an implementation manner, the sample analyzer 10 further includes a reaction vessel providing mechanism 900, a transfer mechanism 910, and a reaction vessel recovery mechanism. The reaction vessel providing mechanism 900 is used to provide the reaction vessel 20, and the reaction vessel recovery mechanism is used to recover the reaction vessel 20. The sample analyzer 10 further forms a recovery position, and the reaction vessel recovery mechanism is located below the recovery position. The transfer mechanism 910 is used to transfer the reaction vessel 20. In this implementation, the reaction vessel 20 is a disposable container, that is, a reaction vessel 20 is recovered after completing one measurement item. Of course, in specific applications, the reaction vessel 20 can also be a recyclable container, that is, after the reaction vessel 20 completes one measurement item, it can be cleaned in the sample analyzer 10 and then reused for other measurement items.
[0257] As an implementation manner, the transfer mechanism 910 includes at least one clamping component and at least one power assembly for driving the clamping component to move.
[0258] As shown in Reference 1, as an implementation, the sample analyzer 10 further includes a sample management mechanism 920 and a sample conveying mechanism 930. The sample management mechanism 920 is used for placing a sample container loaded with a sample to achieve sample loading and storage, and the sample conveying mechanism 930 is used for conveying the sample container output by the sample management mechanism 920 to the sample suction position of the sample dispensing mechanism 600.
[0259] As an implementation, the above sample analyzer 10 is an immunoassay analyzer, which is used to detect immune-related parameters. Of course, in specific applications, the above sample analyzer 10 can also be other analyzers with a magnetic separation mechanism 100.
[0260] This embodiment also provides a magnetic separation mechanism 100, which includes a bearing member 140, a scheduling member 150, at least one first liquid suction member 130, at least one first magnetic member 110 and at least one second magnetic member 120. The first magnetic member 110 includes two paired and spaced-apart first magnetic devices 111. On one side of each first magnetic device 111 (including between the two paired and spaced-apart first magnetic devices 111 or on one side of the two paired and spaced-apart first magnetic devices 111), a first magnetic suction position 1001 is formed. The first magnetic member 110 is used to perform a first magnetic adsorption action on the liquid in the reaction container 20 at the first magnetic suction position 1001 to adsorb and form two magnetic bead groups 30 on the inner side wall of the reaction container 20 at the first magnetic suction position 1001; the second magnetic member 120 is composed of a single second magnetic device 121, and a first liquid suction position 1002 is formed on one side of the single second magnetic device 121. The second magnetic member 120 is used to perform a second magnetic adsorption action on the liquid in the reaction container 20 at the first liquid suction position 1002 to adsorb and form a single magnetic bead group 30 on the inner side wall of the reaction container 20 at the first liquid suction position 1002; the first liquid suction member 130 is used to perform a first liquid suction action on the liquid in the reaction container 20 at the first liquid suction position 1002; the bearing member 140 is at least used to bear the reaction container 20 at the first magnetic suction position 1001 and bear the reaction container 20 at the first liquid suction position 1002; the scheduling member 150 is at least used to schedule the reaction container 20 loaded with the incubated liquid to the first magnetic suction position 1001, and schedule the reaction container 20 after the first magnetic adsorption action to the first liquid suction position 1002. The working principle of the magnetic separation mechanism 100 in this implementation scheme and other structures can refer to the relevant description of the magnetic separation mechanism 100 in the above sample analyzer 10, which will not be elaborated here. It should be noted that the magnetic separation mechanism 100 in this implementation scheme is not limited to being applied in the above sample analyzer 10, and can also be used in other sample analyzers 10, or used as an independent machine.
[0261] In this embodiment, a magnetic field capable of quickly adsorbing magnetic beads is configured at the first magnetic adsorption position 1001 with single magnetic adsorption and no liquid absorption, and at the same time, a magnetic field capable of stabilizing magnetic beads is configured at the first liquid absorption position 1002, so as to reduce the loss of magnetic beads in each of the two links during the magnetic separation process and minimize the total loss of magnetic particles. As a specific implementation, the magnetic field configured at the first magnetic adsorption position 1001 is: magnets are arranged on both opposite sides of the first magnetic adsorption position 1001 to shorten the flying distance of the magnetic beads, so that the magnetic beads can quickly adsorb to the inner wall of the reaction vessel 20. The magnetic field configured at the first liquid absorption position 1002 is: a magnet is arranged on one side of the first liquid absorption position 1002 to gather all the magnetic beads into one point, thereby increasing the stability of the magnetic beads during liquid absorption and realizing the combination of the magnetic field design function of quickly adsorbing at the first magnetic adsorption position 1001 and the magnetic field design function of stably adsorbing at the first liquid absorption position 1002.
[0262] Embodiment 2:
[0263] Referring to Figures 1 to 5 、 Figure 7 and Figure 10 As shown, the main difference between the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment and those in Embodiment 1 lies in the different distribution modes of two paired and spaced first magnetic devices 111, specifically: in Embodiment 1, two paired and spaced first magnetic devices 111 are spaced and oppositely arranged along the radial direction of the accommodation groove, that is, two paired and spaced first magnetic devices 111 are horizontally spaced on opposite sides of the first magnetic adsorption position 1001; while in this embodiment, two paired and spaced first magnetic devices 111 are spaced and vertically arranged along the axial direction of the accommodation groove, that is, two paired and spaced first magnetic devices 111 are vertically spaced on one side of the first magnetic adsorption position 1001.
[0264] Specifically, in this embodiment, a first magnetic adsorption position 1001 is formed on one side of the first magnetic member 110, and the first magnetic member 110 is used to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 at the first magnetic adsorption position 1001 to adsorb and form two magnetic bead clusters 30 on the inner side wall of the reaction vessel 20 at the first magnetic adsorption position 1001. A first liquid absorption position 1002 is formed on one side of the second magnetic member 120, and the second magnetic member 120 is used to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 at the first liquid absorption position 1002 to adsorb and form a single magnetic bead cluster 30 on the inner side wall of the reaction vessel 20 at the first liquid absorption position 1002.
[0265] As an implementation manner of this embodiment, the first magnetic member 110 is composed of two paired and spaced-apart first magnetic devices 111. A receiving groove for receiving the reaction vessel 20 is provided at the first magnetic attraction position 1001. The two paired and spaced-apart first magnetic devices 111 are spaced apart along the axial direction of the receiving groove and are arranged vertically. Specifically, the two paired and spaced-apart first magnetic devices 111 are spaced apart vertically on one side of the first magnetic attraction position 1001, that is, the two paired and spaced-apart first magnetic devices 111 are arranged on the same side of the first magnetic attraction position 1001 and are spaced apart vertically. In this way, the two paired and spaced-apart first magnetic devices 111 at the first magnetic attraction position 1001 can adsorb magnetic beads and the target substances bound to the magnetic beads from different height positions on the same side of the reaction vessel 20, thereby also shortening the distance that the magnetic beads and the target substances bound to the magnetic beads are adsorbed and moved, enabling the magnetic beads and the target substances bound to the magnetic beads to be quickly adsorbed near the inner side wall of the reaction vessel 20, which is conducive to ensuring the adsorption speed at the first magnetic attraction position 1001. In this embodiment, the two magnetic bead clusters 30 adsorbed and formed on the inner side wall of the reaction vessel 20 at the first magnetic attraction position 1001 by the first magnetic member 110 are spaced apart along the height direction of the reaction vessel 20; while in the first embodiment, the two magnetic bead clusters 30 adsorbed and formed on the inner side wall of the reaction vessel 20 at the first magnetic attraction position 1001 by the first magnetic member 110 are spaced apart along the diameter direction of the reaction vessel 20.
[0266] As an implementation manner, the scheduling member 150 is used to drive the bearing member 140 to drive the reaction vessel 20 loaded with the incubated liquid to move to the first magnetic attraction position 1001 and the first liquid suction position 1002 in sequence; the two paired and spaced-apart first magnetic devices 111 are arranged on one side of the movement track of the reaction vessel 20 driven by the scheduling member 150, and the second magnetic device 121 is arranged on one side of the movement track of the reaction vessel 20 driven by the scheduling member 150.
[0267] As an implementation manner, all the first magnetic devices 111 and all the second magnetic devices 121 are arranged on the same side of the movement track, that is, the first magnetic devices 111 are arranged on one side of the movement track, and the second magnetic devices 121 are also arranged on this side of the movement track.
[0268] As an implementation manner, the magnetic separation mechanism 100 further includes a main bracket and a third mounting bracket. The third mounting bracket is used to carry all the first magnetic devices 111 and all the second magnetic devices 121 arranged on one side of the movement track to form a third module, and the third module is connected to the main bracket through the third mounting bracket.
[0269] As an implementation manner, the magnetic separation mechanism 100 further includes at least one third magnetic member 160. The third magnetic member 160 is composed of a single third magnetic device 161. A second magnetic attraction position 1003 is formed on one side of the single third magnetic device 161. The third magnetic member 160 is configured to perform a third magnetic adsorption action on the liquid in the reaction vessel 20 located at the second magnetic attraction position 1003 to adsorb and form a single magnetic bead cluster 30 on the inner side wall of the reaction vessel 20 located at the second magnetic attraction position 1003.
[0270] As an implementation manner, the third mounting bracket is used to carry all the first magnetic devices 111, all the second magnetic devices 121, and all the third magnetic devices 161 provided on one side of the movement track, and forms a third module with all the first magnetic devices 111, all the second magnetic devices 121, and all the third magnetic devices 161 provided on the first side.
[0271] As an implementation manner, the spacing distance between two paired and spaced-apart first magnetic devices 111 is greater than or equal to 10 mm. In this way, it is beneficial to ensure that the two paired and spaced-apart first magnetic devices 111 can adsorb and form two magnetic bead clusters 30 on the inner side wall of the reaction vessel 20 located at the first magnetic attraction position 1001.
[0272] As an implementation manner, at least two first magnetic attraction positions 1001 are formed on one side of each first magnetic device 111 and are sequentially distributed along the movement track of the scheduling member 150 driving the reaction vessel 20 to move.
[0273] As an implementation manner, at least two first magnetic attraction positions 1001 are formed on one side of two paired and spaced-apart first magnetic devices 111 and are sequentially distributed along the movement track of the scheduling member 150 driving the reaction vessel 20 to move.
[0274] As an implementation manner, at least two first liquid attraction positions 1002 are formed on one side of a single second magnetic device 121 and are sequentially distributed along the movement track of the scheduling member 150 driving the reaction vessel 20 to move.
[0275] As an implementation manner, except for the different installation positions, the structure of the third magnetic device 161 can adopt the same setting method as the structure of the second magnetic device 121. For example, the number, distribution method, and polarity orientation method of the third magnets in the third magnetic device 161 can refer to the number, distribution method, and polarity orientation method of the second magnets 1211 in the second magnetic device 121, which will not be elaborated here.
[0276] As an implementation manner, the magnetic separation mechanism 100 further includes at least one first liquid injection member, at least one mixing member 180, at least one fourth magnetic member 190, at least one fifth magnetic member 101, and at least one second liquid suction member 102. The fourth magnetic member 190 includes two paired and spaced-apart fourth magnetic devices 191. A third magnetic suction position 1004 is formed on one side of the two paired and spaced-apart fourth magnetic devices 191. The fourth magnetic member 190 is configured to perform a fourth magnetic adsorption action on the liquid in the reaction vessel 20 located at the third magnetic suction position 1004 to adsorb and form two magnetic bead groups 30 on the inner sidewall of the reaction vessel 20 located at the third magnetic suction position 1004. The fifth magnetic member 101 is composed of a single fifth magnetic device 1011. A second liquid suction position 1005 is formed on one side of the single fifth magnetic device 1011. The fifth magnetic member 101 is configured to perform a fifth magnetic adsorption action on the liquid in the reaction vessel 20 located at the second liquid suction position 1005 to adsorb and form a single magnetic bead group 30 on the inner sidewall of the reaction vessel 20 located at the second liquid suction position 1005. The second liquid suction member 102 is configured to perform a second liquid suction action on the liquid in the reaction vessel 20 located at the second liquid suction position 1005. The scheduling member 150 is further configured to sequentially schedule the reaction vessel 20 after the first liquid suction action to the first liquid injection position 1006, the mixing position 1007, the third magnetic suction position 1004, and the second liquid suction position 1005. The carrying member 140 is further configured to carry the reaction vessel 20 located at the first liquid injection position 1006, carry the reaction vessel 20 located at the mixing position 1007, carry the reaction vessel 20 located at the third magnetic suction position 1004, and carry the reaction vessel 20 located at the second liquid suction position 1005. The first liquid injection member is configured to perform a first liquid injection action of injecting a cleaning liquid on the reaction vessel 20 located at the first liquid injection position 1006 and having completed the first liquid suction action. The mixing member 180 is configured to perform a mixing action on the reaction vessel 20 located at the mixing position 1007 and having completed the first liquid injection action. Wherein, the third magnetic suction position 1004 and the first magnetic suction position 1001 are located at two different positions or at the same position, the second liquid suction position 1005 and the first liquid suction position 1002 are located at two different positions or at the same position, and the first liquid injection position 1006 and the first liquid suction position 1002 are located at two different positions or at the same position.
[0277] Except for the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference may be made to Embodiment 1, which will not be elaborated herein.
[0278] Embodiment 3:
[0279] Refer to Figures 1 to 4 and Figure 11As shown, the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment are mainly different from those in the first embodiment in the distribution manner of two pairs of first magnetic devices 111 that are spaced apart. Specifically, in the first embodiment, the two pairs of first magnetic devices 111 that are spaced apart are arranged at intervals and oppositely along the radial direction of the accommodating groove, that is, the two pairs of first magnetic devices 111 that are spaced apart are arranged at intervals in the horizontal direction on the opposite sides of the first magnetic attraction position 1001; while in this embodiment, the two pairs of first magnetic devices 111 that are spaced apart are arranged at intervals and close to each other along the circumferential direction of the accommodating groove, that is, the two pairs of first magnetic devices 111 that are spaced apart are arranged at intervals in the horizontal direction on one side of the first magnetic attraction position 1001.
[0280] Specifically, the same as in the second embodiment, in this embodiment, a first magnetic attraction position 1001 is formed on one side of the first magnetic member 110. The first magnetic member 110 is used to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic attraction position 1001 to adsorb and form two magnetic bead groups 30 on the inner side wall of the reaction vessel 20 located at the first magnetic attraction position 1001. A first liquid suction position 1002 is formed on one side of the second magnetic member 120. The second magnetic member 120 is used to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002 to adsorb and form a single magnetic bead group 30 on the inner side wall of the reaction vessel 20 located at the first liquid suction position 1002.
[0281] As an implementation manner of this embodiment, the first magnetic member 110 is composed of two paired and spaced-apart first magnetic devices 111. A receiving groove for receiving the reaction vessel 20 is provided at the first magnetic attraction position 1001, and the two paired and spaced-apart first magnetic devices 111 are spaced apart and arranged close to each other along the circumference of the receiving groove. Specifically, the two paired and spaced-apart first magnetic devices 111 are arranged horizontally and spaced apart on one side of the first magnetic attraction position 1001, that is, the two paired and spaced-apart first magnetic devices 111 are arranged on the same side of the first magnetic attraction position 1001 and are spaced apart horizontally. In this way, the two paired and spaced-apart first magnetic devices 111 at the first magnetic attraction position 1001 can adsorb magnetic beads and the target substances bound to the magnetic beads from different horizontal positions on the same side of the reaction vessel 20, thereby also shortening the distance that the magnetic beads and the target substances bound to the magnetic beads are adsorbed and moved, enabling the magnetic beads and the target substances bound to the magnetic beads to be quickly adsorbed near the inner side wall of the reaction vessel 20, which is beneficial to ensuring the adsorption speed at the first magnetic attraction position 1001. In this embodiment, the two magnetic bead clusters 30 formed by the first magnetic member 110 adsorbed on the inner side wall of the reaction vessel 20 at the first magnetic attraction position 1001 are spaced apart along the horizontal circumferential direction of the reaction vessel 20 on the same side of the reaction vessel 20; in the first embodiment, the two magnetic bead clusters 30 formed by the first magnetic member 110 adsorbed on the inner side wall of the reaction vessel 20 at the first magnetic attraction position 1001 are spaced apart along the diameter direction of the reaction vessel 20 on opposite sides of the reaction vessel 20.
[0282] As an implementation manner, the scheduling member 150 is used to drive the carrying member 140 to drive the reaction vessel 20 loaded with the incubated liquid to move to the first magnetic attraction position 1001 and the first liquid suction position 1002 in sequence; the two paired and spaced-apart first magnetic devices 111 are arranged on one side of the movement track of the scheduling member 150 driving the reaction vessel 20 to move, and the second magnetic device 121 is arranged on one side of the movement track of the scheduling member 150 driving the reaction vessel 20 to move.
[0283] As an implementation manner, all the first magnetic devices 111 and all the second magnetic devices 121 are arranged on the same side of the movement track.
[0284] As an implementation manner, the magnetic separation mechanism 100 further includes a main bracket and a third mounting bracket. The third mounting bracket is used to carry all the first magnetic devices 111 and all the second magnetic devices 121 arranged on one side of the movement track to form a third module, and the third module is connected to the main bracket through the third mounting bracket.
[0285] As an implementation manner, the distance between two paired and spaced-apart first magnetic devices 111 is greater than or equal to 10 mm. In this way, it is beneficial to ensure that the two paired and spaced-apart first magnetic devices 111 can adsorb and form two magnetic bead clusters 30 on the inner sidewall of the reaction vessel 20 located at the first magnetic adsorption position 1001.
[0286] Except for the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference can be made to Embodiments 1 to 2, which will not be elaborated here.
[0287] Embodiment 4:
[0288] Refer to Figures 1 to 4 、 Figure 7 and Figure 12 As shown, the main difference between the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment and those in Embodiment 1 lies in that at least one of the number of the first magnets 1111 constituting the first magnetic device 111 and the number of the second magnets 1211 constituting the second magnetic device 121 is different. Specifically, in Embodiment 1, the number of the first magnets 1111 constituting the first magnetic device 111 is two or more, and the number of the second magnets 1211 constituting the second magnetic device 121 is two or more; while in this embodiment, at least one of the number of the first magnets 1111 constituting the first magnetic device 111 and the number of the second magnets 1211 constituting the second magnetic device 121 is one.
[0289] As an implementation manner of this embodiment, the first magnetic device 111 is composed of a single first magnet 1111, and the second magnetic device 121 is composed of a single second magnet 1211, that is: the number of the first magnets 1111 constituting the first magnetic device 111 is one, and the number of the first magnets 1111 constituting the first magnetic device 111 is also one.
[0290] Alternatively, as an alternative implementation scheme, the first magnetic device 111 is composed of a single first magnet 1111, and the second magnetic device 121 is composed of two adjacent and paired second magnets 1211. One end of the two adjacent and paired second magnets 1211 close to the first liquid absorption position 1002 abuts against each other or one side of the two adjacent and paired second magnets 1211 contacts each other. The second magnetic device 121 being composed of two adjacent and paired second magnets 1211 includes any of the following situations: the second magnetic device 121 is composed of two second magnets 1211 stacked in the vertical direction, the second magnetic device 121 is composed of two second magnets 1211 abutting against each other in the horizontal circumferential direction, and the second magnetic device 121 is composed of two second magnets 1211 abutting against each other in the inclined direction.
[0291] Alternatively, as another alternative embodiment, the first magnetic device 111 is composed of two adjacent and paired first magnets 1111, and the second magnetic device 121 is composed of a single second magnet 1211. One end of the two adjacent and paired first magnets 1111 close to the first magnetic attraction position 1001 abuts against each other, or one side of the two adjacent and paired first magnets 1111 contacts each other. The first magnetic device 111 being composed of two adjacent and paired second magnets 1211 includes any of the following situations: the first magnetic device 111 is composed of two first magnets 1111 stacked vertically, the first magnetic device 111 is composed of two first magnets 1111 abutting against each other along the horizontal circumferential direction, and the first magnetic device 111 is composed of two first magnets 1111 abutting against each other along the inclined direction.
[0292] As an implementation manner, the two magnetic poles of the same first magnet 1111 are arranged horizontally, that is, the N pole and the S pole of the same first magnet 1111 are horizontally placed, and the N pole is on the left or right or front or back side of the S pole. One magnetic pole of the first magnet 1111 is arranged facing the first magnetic attraction position 1001, and the other magnetic pole extends horizontally away from the first magnetic attraction position 1001. For example, the first magnet 1111 is arranged with the N pole facing the first magnetic attraction position 1001 and the S pole facing away from the first magnetic attraction position 1001 horizontally; or, the first magnet 1111 is arranged with the S pole facing the first magnetic attraction position 1001 and the N pole facing away from the first magnetic attraction position 1001 horizontally.
[0293] As an implementation manner, the two magnetic poles of the same second magnet 1211 are arranged horizontally, that is, the N pole and the S pole of the same second magnet 1211 are horizontally placed, and the N pole is on the left or right or front or back side of the S pole. Of course, in specific applications, the two magnetic poles of the second magnet 1211 are not limited to being horizontally arranged. For example, as an alternative embodiment, the two magnetic poles of the same second magnet 1211 are arranged vertically, that is, the N pole and the S pole of the same second magnet 1211 are vertically placed, and the N pole is above or below the S pole; or, as another alternative embodiment, the two magnetic poles of the same second magnet 1211 are arranged obliquely, that is, the N pole and the S pole of the same second magnet 1211 are placed in an inclined straight line, and the N pole is above or below the S pole obliquely.
[0294] Except for the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference can be made to Embodiments 1 to 3, which will not be elaborated here.
[0295] Embodiment 5:
[0296] Refer to Figures 1 to 4 、 Figure 7 and Figure 13As shown in the figure, the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment are mainly different from those in the first embodiment in the setting manner of the second magnetic member 120, specifically reflected in: in the first embodiment, the second magnetic member 120 is composed of two second magnets 1211 stacked, and the two magnetic poles of the second magnet 1211 are arranged in the horizontal direction; while in this embodiment, the second magnetic member 120 is composed of one second magnet 1211, and the two magnetic poles of the second magnet 1211 are arranged in the vertical direction.
[0297] As an implementation manner, in this embodiment, the second magnetic member 120 is composed of a single second magnetic device 121, and a first liquid suction position 1002 is formed on one side of the single second magnetic device 121. The second magnetic device 121 is composed of a single second magnet 1211. The two magnetic poles of the second magnet 1211 are arranged in the vertical direction.
[0298] As an implementation manner, the first magnetic member 110 is composed of two paired and spaced-apart first magnetic devices 111.
[0299] As an implementation manner, the first magnetic device 111 is composed of two first magnets 1111 stacked in the vertical direction. Of course, in specific applications, the first magnetic device 111 can also be composed of one first magnet 1111.
[0300] As an implementation manner, the two magnetic poles of the same first magnet 1111 are arranged in the horizontal direction.
[0301] Except for the above, other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment can refer to the first to fourth embodiments, and will not be elaborated here.
[0302] Embodiment Six:
[0303] Refer to Figures 1 to 4 、 Figure 7 and Figure 14 As shown in the figure, the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment are mainly different from those in the first embodiment in at least one of the relative positions of the two first magnets 1111 constituting the first magnetic device 111 and the relative positions of the two second magnets 1211 constituting the second magnetic device 121, specifically reflected in: in the first embodiment, the two first magnets 1111 constituting the first magnetic device 111 are stacked in the vertical direction, and the two second magnets 1211 constituting the second magnetic device 121 are stacked in the vertical direction; while in this embodiment, the mutual position relationship of at least one of the two first magnets 1111 constituting the first magnetic device 111 and the two second magnets 1211 constituting the second magnetic device 121 is arranged in contact with each other in the horizontal direction.
[0304] As an implementation manner of this embodiment, the first magnetic device 111 is composed of two first magnets 1111 that are in contact with each other in the horizontal direction, and the second magnetic device 121 is composed of two second magnets 1211 that are in contact with each other in the horizontal direction. Alternatively, as an alternative implementation, the first magnetic device 111 is composed of two first magnets 1111 that are in contact with each other in the horizontal direction, and the second magnetic device 121 is composed of two second magnets 1211 that are stacked in the vertical direction; or, as another alternative implementation, the first magnetic device 111 is composed of two first magnets 1111 that are stacked in the vertical direction, and the second magnetic device 121 is composed of two second magnets 1211 that are in contact with each other in the horizontal direction.
[0305] Taking the first magnetic device 111 being composed of two first magnets 1111 that are in contact with each other in the horizontal direction and the second magnetic device 121 being composed of two second magnets 1211 that are in contact with each other in the horizontal direction as an example, the following further description is provided.
[0306] As an implementation manner, the magnetic poles of the two first magnets 1111 that constitute the first magnetic device 111 and are close to the first magnetic attraction position 1001 are in contact with each other, and the magnetic poles of the two second magnets 1211 that constitute the second magnetic device 121 and are close to the first magnetic attraction liquid level 1002 are in contact with each other.
[0307] As an implementation manner, the polarities of the magnetic poles of the two first magnets 1111 that are in contact with each other in the horizontal direction in the same first magnetic device 111 and face the same first magnetic attraction position 1001 are opposite, and the polarities of the magnetic poles of the two second magnets 1211 that are in contact with each other in the horizontal direction in the same second magnetic device 121 and face the same first magnetic attraction liquid level 1002 are opposite. In this way, the principle of opposite-sex attraction can be utilized to facilitate the installation of the first magnetic device 111 and the second magnetic device 121.
[0308] As an implementation manner, the two magnetic poles of the same first magnet 1111 are arranged in the horizontal direction, that is, the N pole and the S pole of the same first magnet 1111 are horizontally placed, and the N pole is on the left or right or front or back side of the S pole. One magnetic pole of the first magnet 1111 is arranged facing the first magnetic attraction position 1001, and the other magnetic pole extends horizontally away from the first magnetic attraction position 1001. For example, the first magnet 1111 is arranged with the N pole facing the first magnetic attraction position 1001 and the S pole facing away from the first magnetic attraction position 1001 horizontally; or, the first magnet 1111 is arranged with the S pole facing the first magnetic attraction position 1001 and the N pole facing away from the first magnetic attraction position 1001 horizontally.
[0309] As an implementation manner, the two magnetic poles of the same second magnet 1211 are arranged in the horizontal direction, that is, the N pole and the S pole of the same second magnet 1211 are horizontally placed, and the N pole is on the left or right or front or back side of the S pole. Of course, in specific applications, the two magnetic poles of the second magnet 1211 are not limited to being horizontally arranged. For example, as an alternative implementation manner, the two magnetic poles of the same second magnet 1211 are arranged in the vertical direction, that is, the N pole and the S pole of the same second magnet 1211 are vertically placed, and the N pole is above or below the S pole; or, as another alternative implementation manner, the two magnetic poles of the same second magnet 1211 are arranged in the inclined direction, that is, the N pole and the S pole of the same second magnet 1211 are placed in an inclined straight line, and the N pole is diagonally above or below the S pole.
[0310] It should be noted that the relative positions of the two first magnets 1111 constituting the first magnetic device 111 and the relative positions of the two second magnets 1211 constituting the second magnetic device 121 are not limited to the situations of this embodiment and the above-mentioned first embodiment. For example, the two first magnets 1111 constituting the first magnetic device 111 can also be arranged to abut against each other in the inclined direction, and / or the two second magnets 1211 constituting the second magnetic device 121 can also be arranged to abut against each other in the inclined direction.
[0311] Except for the above, other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment can refer to the first to fifth embodiments, and will not be elaborated here.
[0312] Embodiment Seven:
[0313] Refer to Figures 1 to 4 and Figure 15 As shown, the main difference between the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment and those in the first embodiment lies in the different polarity setting methods of the magnetic poles of the two first magnets 1111 in the same layer facing the same first magnetic adsorption position 1001. Specifically, in the first embodiment, the polarities of the magnetic poles of the two first magnets 1111 in the same layer facing the same first magnetic adsorption position 1001 are the same; while in this embodiment, the polarities of the magnetic poles of the two first magnets 1111 in the same layer facing the same first magnetic adsorption position 1001 are opposite.
[0314] As an implementation manner of this embodiment, among the two paired and spaced first magnetic devices 111 of the same first magnetic member 110, the polarities of the magnetic poles of the two first magnets 1111 distributed on the opposite sides of the same first magnetic adsorption position 1001 and at the same height position facing the same first magnetic adsorption position 1001 are opposite. By adopting this setting method, two magnetic bead clusters 30 can also be adsorbed and formed on the inner side wall of the reaction vessel 20 at the first magnetic adsorption position 1001 by the first magnetic member 110.
[0315] In addition to the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference can be made to Embodiments 1 to 6, which will not be elaborated here.
[0316] Embodiment 8:
[0317] Referring to Figures 1 to 4 、 Figure 7 and Figure 16 As shown, the main difference between the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment and those in Embodiment 1 lies in the setting manner of the first magnetic member 110. Specifically, in Embodiment 1, the first magnetic member 110 is composed of two paired and spaced-apart first magnetic devices 111, and the magnets of the first magnetic member 110 are distributed on opposite sides of the reaction vessel 20 at the first magnetic attraction position 1001; while in this embodiment, the first magnetic member 110 is composed of a single first magnetic device 111, and the magnets of the first magnetic member 110 are distributed on one side of the reaction vessel 20 at the first magnetic attraction position 1001.
[0318] As an implementation manner, the sample analyzer 10 provided in this embodiment includes a sample dispensing mechanism 600, a reagent dispensing mechanism 700, an incubation mechanism 400, a magnetic separation mechanism 100, a measurement mechanism 200, and a controller 300. The sample dispensing mechanism 600 is used to aspirate a sample from a sample container and dispense it into the reaction vessel 20; the reagent dispensing mechanism 700 is at least used to aspirate a first reagent from a first reagent container and dispense it into the reaction vessel 20, and the first reagent contains magnetic beads; the incubation mechanism 400 is used to incubate the liquid formed at least by the sample and the first reagent in the reaction vessel 20; the magnetic separation mechanism 100 is used to perform a magnetic separation operation on the liquid in the reaction vessel 20 after incubation. The measurement mechanism 200 is used to measure the test liquid prepared at least from the liquid after the magnetic separation operation in the reaction vessel 20 to obtain measurement information. The controller 300 is configured to: output the measurement result of the sample according to the measurement information of the measurement mechanism 200.
[0319] As an implementation manner, the magnetic separation mechanism 100 includes a bearing member 140, a scheduling member 150, at least one first liquid absorption member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The first magnetic member 110 is composed of a single first magnetic device 111, and the single first magnetic device 111 is composed of at least three first magnets 1111 stacked in the vertical direction or composed of at least three first magnets 1111 abutting against each other in the horizontal direction. A first magnetic adsorption position 1001 is formed on one side of the single first magnetic device 111. The first magnetic member 110 is configured to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic adsorption position 1001 to adsorb and form at least two magnetic bead clusters 30 on the inner side wall of the reaction vessel 20 located at the first magnetic adsorption position 1001. The second magnetic member 120 is composed of a single second magnetic device 121, and the single second magnetic member is composed of a second magnet 1211 or at least two second magnets 1211 abutting against each other in the horizontal direction or at least two second magnets 1211 stacked in the vertical direction. The number of first magnets 1111 included in the single first magnetic device 111 is greater than the number of second magnets 1211 included in the single second magnetic device 121. A first liquid absorption position 1002 is formed on one side of the single second magnetic device 121. The second magnetic member 120 is configured to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid absorption position 1002 to adsorb and form at least one magnetic bead cluster 30 on the inner side wall of the reaction vessel 20 located at the first magnetic adsorption position 1001. The first liquid absorption member 130 is configured to perform a first liquid absorption action on the liquid in the reaction vessel 20 located at the first liquid absorption position 1002. The bearing member 140 is at least configured to bear the reaction vessel 20 located at the first magnetic adsorption position 1001 and bear the reaction vessel 20 located at the first liquid absorption position 1002. The scheduling member 150 is at least configured to schedule the reaction vessel 20 loaded with the incubated liquid to the first magnetic adsorption position 1001 and schedule the reaction vessel 20 after the first magnetic adsorption action is completed to the first liquid absorption position 1002.
[0320] In this embodiment, by arranging more than three first magnets 1111 on one side of the first magnetic adsorption position 1001, the purpose of adsorbing and forming more than two magnetic bead clusters 30 on the reaction vessel 20 at the first magnetic adsorption position 1001 can also be achieved. Since the second magnet 1211 is also arranged on one side at the first liquid absorption position 1002, and the number of first magnets 1111 providing a magnetic field for one first magnetic adsorption position 1001 is greater than the number of second magnets 1211 providing a magnetic field for one first liquid absorption position 1002, the purpose of making the adsorption speed of the magnetic bead clusters 30 at the first magnetic adsorption position 1001 greater than the adsorption speed at the first liquid absorption position 1002 and the purpose of making the adsorption stability of the magnetic bead clusters 30 at the first liquid absorption position 1002 greater than the adsorption stability at the first magnetic adsorption position 1001 can also be achieved.
[0321] As an implementation manner, the first magnetic device 111 is composed of at least three first magnets 1111 stacked in the vertical direction, and the second magnetic device 121 is composed of a single second magnet 1211 or two second magnets 1211 stacked in the vertical direction. Alternatively, as an alternative implementation manner, the first magnetic device 111 is composed of at least three first magnets 1111 abutting against each other in the horizontal direction in sequence, and the second magnetic device 121 is composed of a single second magnet 1211 or two second magnets 1211 abutting against each other in the horizontal direction. Or, as another alternative implementation manner, the first magnetic device 111 is composed of at least three first magnets 1111 abutting against each other in the inclined direction in sequence, and the second magnetic device 121 is composed of a single second magnet 1211 or two second magnets 1211 abutting against each other in the inclined direction.
[0322] As an implementation manner, the scheduling member 150 is used to drive the carrying member 140 to drive the reaction vessel 20 loaded with the incubated liquid to move to the first magnetic attraction position 1001 and the first liquid suction position 1002 in sequence; the first magnetic device 111 and the second magnetic device 121 are arranged on the same side of the movement track of the reaction vessel 20 driven by the scheduling member 150.
[0323] As an implementation manner, the carrying member 140 is in a disc shape, and the carrying member 140 is formed with a plurality of accommodating grooves arranged along the circumferential direction of the disc-shaped carrying member 140. Each accommodating groove is used to accommodate a reaction vessel 20, and the scheduling member 150 is used to drive the carrying member 140 to drive the reaction vessel 20 to horizontally rotate around the central axis of the carrying member 140, so that the reaction vessels 20 accommodated in the accommodating grooves are sequentially scheduled to the first magnetic attraction position 1001 and the first liquid suction position 1002.
[0324] As an implementation manner, the magnetic separation mechanism 100 provided in this embodiment includes a bearing member 140, a scheduling member 150, at least one first liquid suction member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The first magnetic member 110 is composed of a single first magnetic device 111. The single first magnetic device 111 is composed of at least three first magnets 1111 stacked in the vertical direction or composed of at least three first magnets 1111 abutting against each other in the horizontal direction. A first magnetic suction position 1001 is formed on one side of the single first magnetic device 111. The first magnetic member 110 is configured to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic suction position 1001 to adsorb and form at least two magnetic bead clusters 30 on the inner side wall of the reaction vessel 20 located at the first magnetic suction position 1001. The second magnetic member 120 is composed of a single second magnetic device 121. The single second magnetic member is composed of one second magnet 1211, or at least two second magnets 1211 abutting against each other in the horizontal direction, or at least two second magnets 1211 stacked in the vertical direction. The number of first magnets 1111 included in the single first magnetic device 111 is greater than the number of second magnets 1211 included in the single second magnetic device 121. A first liquid suction position 1002 is formed on one side of the single second magnetic device 121. The second magnetic member 120 is configured to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002 to adsorb and form at least one magnetic bead cluster 30 on the inner side wall of the reaction vessel 20 located at the first magnetic suction position 1001. The first liquid suction member 130 is configured to perform a first liquid suction action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002. The bearing member 140 is at least configured to bear the reaction vessel 20 located at the first magnetic suction position 1001 and bear the reaction vessel 20 located at the first liquid suction position 1002. The scheduling member 150 is at least configured to schedule the reaction vessel 20 loaded with the incubated liquid to the first magnetic suction position 1001, and schedule the reaction vessel 20 after completing the first magnetic adsorption action to the first liquid suction position 1002.
[0325] In addition to the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference can be made to Embodiments 1 to 7, which will not be elaborated here.
[0326] Embodiment Nine:
[0327] The sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment are mainly different from those in the first embodiment in that: in this embodiment, it is not limited whether the first magnetic member 110 is composed of two paired and spaced first magnetic devices 111, and it only needs to satisfy that the number of first magnets 1111 included in one first magnetic member 110 is greater than the number of second magnets 1211 included in the second magnetic member 120, and the first magnetic member 110 includes at least two spaced first magnets 1111.
[0328] As an implementation manner, the sample analyzer 10 provided in this embodiment includes a sample dispensing mechanism 600, a reagent dispensing mechanism 700, an incubation mechanism 400, a magnetic separation mechanism 100, a measurement mechanism 200, and a controller 300. The sample dispensing mechanism 600 is configured to aspirate a sample from a sample container and dispense it into a reaction container 20. The reagent dispensing mechanism 700 is at least configured to aspirate a first reagent from a first reagent container and dispense it into the reaction container 20, and the first reagent contains magnetic beads. The incubation mechanism 400 is configured to incubate the liquid formed at least by the sample and the first reagent in the reaction container 20. The magnetic separation mechanism 100 is configured to perform a magnetic separation operation on the liquid in the reaction container 20 after incubation. The measurement mechanism 200 is configured to measure the test liquid formed at least by the liquid after the magnetic separation operation in the reaction container 20 to obtain measurement information. The controller 300 is configured to: output the measurement result of the sample according to the measurement information of the measurement mechanism 200.
[0329] As an implementation manner, the magnetic separation mechanism 100 includes a bearing member 140, a scheduling member 150, at least one first liquid suction member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The first magnetic member 110 is composed of at least two first magnets 1111 arranged at intervals. A first magnetic attraction position 1001 is formed between the at least two first magnets 1111 arranged at intervals. The first magnetic member 110 is configured to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic attraction position 1001. The second magnetic member 120 is composed of one second magnet 1211 or at least two second magnets 1211. A first liquid suction position 1002 is formed on one side of one second magnet 1211, or on one side of at least two second magnets 1211, or between at least two second magnets 1211. The second magnetic member 120 is configured to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002. The number of first magnets 1111 included in one first magnetic member 110 is greater than the number of second magnets 1211 included in one second magnetic member 120. The first liquid suction member 130 is configured to perform a first liquid suction action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002. The bearing member 140 is at least configured to bear the reaction vessel 20 located at the first magnetic attraction position 1001 and bear the reaction vessel 20 located at the first liquid suction position 1002. The scheduling member 150 is at least configured to schedule the reaction vessel 20 loaded with the incubated liquid to the first magnetic attraction position 1001, and schedule the reaction vessel 20 after the first magnetic adsorption action is completed to the first liquid suction position 1002. In this embodiment, the purpose of making the adsorption speed of the magnetic bead group 30 at the first magnetic attraction position 1001 greater than that at the first liquid suction position 1002 and the purpose of making the adsorption stability of the magnetic bead group 30 at the first liquid suction position 1002 greater than that at the first magnetic attraction position 1001 can also be achieved.
[0330] As an implementation manner, the first magnetic member 110 is composed of four first magnets 1111. The four first magnets 1111 are arranged in two groups on opposite sides of the first magnetic attraction position 1001, that is: two of the four first magnets 1111 are stacked or abutted against each other horizontally on one side of the first magnetic attraction position 1001, and the other two first magnets 1111 are stacked or abutted against each other horizontally on the other side of the first magnetic attraction position 1001. The second magnetic member 120 is composed of one second magnet 1211 arranged on one side of the first liquid suction position 1002, or composed of two second magnets 1211 stacked on one side of the first liquid suction position 1002, or composed of two second magnets 1211 abutted against each other horizontally on one side of the first liquid suction position 1002.
[0331] Alternatively, as an alternative embodiment, the first magnetic member 110 is composed of two first magnets 1111, which are respectively arranged on opposite sides of the first magnetic attraction position 1001. The second magnetic member 120 is composed of a second magnet 1211 arranged on one side of the first liquid absorption position 1002, or composed of two second magnets 1211 stacked on one side of the first liquid absorption position 1002, or composed of two second magnets 1211 arranged in contact with each other in the horizontal direction on one side of the first liquid absorption position 1002.
[0332] A magnetic separation mechanism 100 provided in this embodiment includes a carrier member 140, a scheduling member 150, at least one first liquid absorption member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The first magnetic member 110 is composed of at least two spaced-apart first magnets 1111, and a first magnetic attraction position 1001 is formed between the at least two spaced-apart first magnets 1111. The first magnetic member 110 is configured to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic attraction position 1001. The second magnetic member 120 is composed of a second magnet 1211 or at least two second magnets 1211. A first liquid absorption position 1002 is formed on one side of the second magnet 1211, or on one side of the at least two second magnets 1211, or between the at least two second magnets 1211. The second magnetic member 120 is configured to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid absorption position 1002. The number of first magnets 1111 included in one first magnetic member 110 is greater than the number of second magnets 1211 included in one second magnetic member 120. The first liquid absorption member 130 is configured to perform a first liquid absorption action on the liquid in the reaction vessel 20 located at the first liquid absorption position 1002. The carrier member 140 is at least configured to carry the reaction vessel 20 located at the first magnetic attraction position 1001 and carry the reaction vessel 20 located at the first liquid absorption position 1002. The scheduling member 150 is at least configured to schedule the reaction vessel 20 loaded with the incubated liquid to the first magnetic attraction position 1001, and schedule the reaction vessel 20 after the first magnetic adsorption action is completed to the first liquid absorption position 1002.
[0333] In addition to the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference can be made to Embodiments 1 to 8, which will not be elaborated here.
[0334] Embodiment Ten:
[0335] The sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment are mainly different from those in the first embodiment in that: in this embodiment, the structures of the first magnetic member 110 and the second magnetic member 120 are not limited, and it is only necessary to ensure that the number of magnetic bead clusters 30 adsorbed by the first magnetic member 110 on one reaction vessel 20 at the first magnetic adsorption position 1001 is greater than the number of magnetic bead clusters 30 adsorbed by the second magnetic member 120 on one reaction vessel 20 at the first liquid suction position 1002.
[0336] As an implementation manner, the sample analyzer 10 provided in this embodiment includes a sample dispensing mechanism 600, a reagent dispensing mechanism 700, an incubation mechanism 400, a magnetic separation mechanism 100, a measurement mechanism 200, and a controller 300. The sample dispensing mechanism 600 is used to suck a sample from a sample container and dispense it into the reaction vessel 20. The reagent dispensing mechanism 700 is at least used to suck a first reagent from a first reagent container and dispense it into the reaction vessel 20, and the first reagent contains magnetic beads. The incubation mechanism 400 is used to incubate the liquid formed at least by the sample and the first reagent in the reaction vessel 20. The magnetic separation mechanism 100 is used to perform a magnetic separation operation on the liquid after incubation in the reaction vessel 20. The measurement mechanism 200 is used to measure the test liquid formed at least by the liquid after the magnetic separation operation in the reaction vessel 20 to obtain measurement information. The controller 300 is configured to: output the measurement result of the sample according to the measurement information of the measurement mechanism 200.
[0337] As an implementation manner, the magnetic separation mechanism 100 includes a carrying member 140, a scheduling member 150, at least one first liquid suction member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The scheduling member 150 is configured to sequentially schedule the reaction vessel 20 loaded with the incubated liquid along a preset trajectory to a first magnetic attraction position 1001 and a first liquid suction position 1002. The carrying member 140 is at least configured to carry the reaction vessel 20 located at the first magnetic attraction position 1001 and the reaction vessel 20 located at the first liquid suction position 1002. The first magnetic member 110 is configured to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic attraction position 1001 to adsorb and form a first number of magnetic bead clusters 30 on the inner sidewall of the reaction vessel 20 located at the first magnetic attraction position 1001. The second magnetic member 120 is configured to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002 to adsorb and form a second number of magnetic bead clusters 30 on the inner sidewall of the reaction vessel 20 located at the first liquid suction position 1002. The first liquid suction member 130 is configured to perform a first liquid suction action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002. The first number is greater than or equal to two, and the first number is greater than the second number. In this embodiment, by setting the number of magnetic bead clusters 30 adsorbed by the first magnetic member 110 in one reaction vessel 20 at the first magnetic attraction position 1001 to be greater than the number of magnetic bead clusters 30 adsorbed by the second magnetic member 120 in one reaction vessel 20 at the first liquid suction position 1002, it is also possible to achieve the purpose of making the adsorption speed of the magnetic bead clusters 30 at the first magnetic attraction position 1001 greater than that at the first liquid suction position 1002 and the purpose of making the adsorption stability of the magnetic bead clusters 30 at the first liquid suction position 1002 greater than that at the first magnetic attraction position 1001.
[0338] As an implementation manner, when the first magnetic component 110 performs the first magnetic adsorption action, at least two bead clusters 30 arranged along the circumferential direction of the reaction vessel 20 are adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first magnetic adsorption position 1001; when the second magnetic component 120 performs the second magnetic adsorption action, a single bead cluster 30 is adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002. In this implementation scheme, among all the bead clusters 30 adsorbed and formed by the first magnetic component 110 on one reaction vessel 20 at the first magnetic adsorption position 1001, at least two bead clusters 30 distributed in the horizontal direction are included, and a single bead cluster 30 is adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002, achieving the effect that the number of bead clusters 30 adsorbed and formed by the first magnetic component 110 on one reaction vessel 20 at the first magnetic adsorption position 1001 is greater than the number of bead clusters 30 adsorbed and formed by the second magnetic component 120 on one reaction vessel 20 at the first liquid adsorption position 1002. For the specific implementation manners in which at least two bead clusters 30 distributed in the horizontal direction are included among all the bead clusters 30 adsorbed and formed by the first magnetic component 110 on one reaction vessel 20 at the first magnetic adsorption position 1001, reference may be made to Embodiment 1, Embodiment 3, Embodiment 4, Embodiment 5, Embodiment 6, Embodiment 7, and Embodiment 9, which will not be elaborated herein.
[0339] As an implementation manner, the first magnetic component 110 includes at least two first magnets 1111 spaced apart in the horizontal circumferential direction, and the second magnetic component 120 is composed of a single second magnet 1211 or two second magnets 1211 stacked in the vertical direction. In this way, it can be achieved that when the first magnetic component 110 performs the first magnetic adsorption action, at least two bead clusters 30 arranged along the circumferential direction of the reaction vessel 20 are adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first magnetic adsorption position 1001; when the second magnetic component 120 performs the second magnetic adsorption action, a single bead cluster 30 is adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002.
[0340] As an alternative implementation of the arrangement of the magnetic bead clusters 30 along the circumferential direction of the reaction vessel 20, when the first magnetic member 110 performs the first magnetic adsorption action, at least two magnetic bead clusters 30 arranged along the height direction of the reaction vessel 20 are adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first magnetic adsorption position 1001; when the second magnetic member 120 performs the second magnetic adsorption action, a single magnetic bead cluster 30 is adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002. Among all the magnetic bead clusters 30 adsorbed and formed by the first magnetic member 110 on one reaction vessel 20 at the first magnetic adsorption position 1001, there may only be at least two magnetic bead clusters 30 distributed horizontally; or there may only be at least two magnetic bead clusters 30 distributed vertically; or there may be both at least two magnetic bead clusters 30 distributed horizontally and at least two magnetic bead clusters 30 distributed vertically. For the specific implementation manners in which among all the magnetic bead clusters 30 adsorbed and formed by the first magnetic member 110 on one reaction vessel 20 at the first magnetic adsorption position 1001, there are at least two magnetic bead clusters 30 spaced apart along the height direction of the reaction vessel 20, reference may be made to, for example, Embodiment 2 and Embodiment 8, which will not be elaborated here.
[0341] As an implementation manner, the first magnetic member 110 includes at least three first magnets 1111 stacked along the vertical direction, and the second magnetic member 120 is composed of a single second magnet 1211 or two second magnets 1211 stacked along the vertical direction. In this way, it can be achieved that when the first magnetic member 110 performs the first magnetic adsorption action, at least two magnetic bead clusters 30 spaced apart along the height direction of the reaction vessel 20 are adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first magnetic adsorption position 1001; when the second magnetic member 120 performs the second magnetic adsorption action, a single magnetic bead cluster 30 is adsorbed and formed on the inner sidewall of the reaction vessel 20 at the first liquid adsorption position 1002.
[0342] As an implementation manner, the height position of the magnetic bead cluster 30 adsorbed and formed on the inner sidewall of the reaction vessel 20 when the first magnetic member 110 performs the first magnetic adsorption action is lower than the height position of the magnetic bead cluster 30 adsorbed and formed on the inner sidewall of the reaction vessel 20 when the second magnetic member 120 performs the second magnetic adsorption action; and / or, the height position of the first magnetic member 110 is lower than the height position of the second magnetic member 120.
[0343] As an implementation manner, the first magnetic member 110 is composed of a first magnetic device 111 or at least two first magnetic devices 111 arranged at intervals, the second magnetic member 120 is composed of a second magnetic device 121 or at least two second magnetic devices 121 arranged at intervals, the first magnetic device 111 is composed of at least one first magnet 1111, and the second magnetic device 121 is composed of at least one second magnet 1211; and the number of first magnets 1111 included in one first magnetic device 111 is greater than or equal to the number of second magnets 1211 included in the second magnetic device 121 or one less than the number of second magnets 1211 included in the second magnetic device 121. When the number of first magnetic devices 111 in the first magnetic member 110 is one, the number of first magnets 1111 in the first magnetic device 111 is greater than or equal to three; when the number of first magnetic devices 111 in the first magnetic member 110 is at least two, the number of first magnets 1111 in the first magnetic device 111 is at least one. The number of first magnets 1111 included in one first magnetic device 111 is one less than the number of second magnets 1211 included in the second magnetic device 121. For example, the first magnetic member 110 is composed of two first magnetic devices 111 respectively distributed on opposite sides of the first magnetic attraction position 1001, the first magnetic device 111 is composed of one first magnet 1111, the second magnetic member 120 is composed of a single second magnetic device 121 distributed on one side of the first magnetic attraction liquid level 1002, and the second magnetic device 121 is composed of two second magnets 1211 stacked.
[0344] As an implementation manner, the first magnetic member 110 is composed of a single first magnetic device 111, the second magnetic member 120 is composed of at least two second magnetic devices 121 arranged at intervals, the first magnetic device 111 is composed of at least four first magnets 1111 stacked in the vertical direction or abutted in sequence in the horizontal direction, the second magnetic device 121 is composed of a single second magnet 1211 or two second magnets 1211 stacked in the vertical direction or abutted to each other in the horizontal direction, and the number of first magnets 1111 included in the first magnetic member 110 is at least two more than the number of second magnetic devices 121 included in the second magnetic member 120. In this way, it can also achieve the purpose of making the number of magnetic bead clusters 30 adsorbed by the first magnetic member 110 on a reaction vessel 20 at the first magnetic attraction position 1001 greater than the number of magnetic bead clusters 30 adsorbed by the second magnetic member 120 on a reaction vessel 20 at the first magnetic attraction liquid level 1002.
[0345] As an implementation manner, the first magnetic member 110 is composed of at least two first magnetic devices 111 arranged at intervals, and the second magnetic member 120 is composed of a single second magnetic device 121. In this way, the purpose can be achieved that the number of magnetic bead clusters 30 adsorbed by the first magnetic member 110 on a reaction vessel 20 at the first magnetic adsorption position 1001 is greater than the number of magnetic bead clusters 30 adsorbed by the second magnetic member 120 on a reaction vessel 20 at the first liquid suction position 1002. Alternatively, as an alternative implementation manner, the first magnetic member 110 is composed of at least two first magnetic devices 111 arranged at intervals, and the second magnetic member 120 is composed of at least two second magnetic devices 121 arranged at intervals. The first magnetic device 111 is composed of a single first magnet 1111 or at least two first magnets 1111 stacked in the vertical direction or abutting against each other in sequence in the horizontal direction, and the second magnetic device 121 is composed of a single second magnet 1211 or at least two second magnets 1211 stacked in the vertical direction or abutting against each other in sequence in the horizontal direction. The former parameter of one of the following two parameter groups of the first magnetic member 110 and the second magnetic member 120 is greater than the latter parameter, and the former parameter of the other parameter group is greater than or equal to the latter parameter: the number of the first magnetic devices 111 and the number of the second magnetic devices 121, and the interval distance between two adjacent first magnetic devices 111 in the same first magnetic member 110 and the interval distance between two adjacent second magnetic devices 121 in the same second magnetic member 120.
[0346] As an implementation manner, the first magnetic member 110 is composed of at least three first magnetic devices 111 arranged at intervals, and the second magnetic member 120 is composed of two second magnetic devices 121 arranged at intervals. The interval distance between two adjacent first magnetic devices 111 in the same first magnetic member 110 is greater than or equal to the interval distance between two adjacent second magnetic devices 121 in the same second magnetic member 120. In this way, the purpose can be achieved that the number of magnetic bead clusters 30 adsorbed by the first magnetic member 110 on a reaction vessel 20 at the first magnetic adsorption position 1001 is greater than the number of magnetic bead clusters 30 adsorbed by the second magnetic member 120 on a reaction vessel 20 at the first liquid suction position 1002. Alternatively, as an alternative implementation scheme, the first magnetic member 110 is composed of two first magnetic devices 111 arranged at intervals, and the second magnetic member 120 is composed of two second magnetic devices 121 arranged at intervals. The interval distance between two adjacent first magnetic devices 111 in the same first magnetic member 110 is greater than the interval distance between two adjacent second magnetic devices 121 in the same second magnetic member 120.
[0347] A magnetic separation mechanism 100 provided in this embodiment includes a carrying member 140, a scheduling member 150, at least one first liquid suction member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The scheduling member 150 is configured to sequentially schedule a reaction vessel 20 loaded with incubated liquid along a preset trajectory to a first magnetic attraction position 1001 and a first liquid suction position 1002. The carrying member 140 is at least configured to carry the reaction vessel 20 located at the first magnetic attraction position 1001 and the reaction vessel 20 located at the first liquid suction position 1002. The first magnetic member 110 is configured to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic attraction position 1001 to adsorb and form a first number of magnetic bead clusters 30 on the inner sidewall of the reaction vessel 20 located at the first magnetic attraction position 1001. The second magnetic member 120 is configured to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002 to adsorb and form a second number of magnetic bead clusters 30 on the inner sidewall of the reaction vessel 20 located at the first liquid suction position 1002. The first liquid suction member 130 is configured to perform a first liquid suction action on the liquid in the reaction vessel 20 located at the first liquid suction position 1002. The first number is greater than or equal to two, and the first number is greater than the second number.
[0348] Except for the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference can be made to Embodiments 1 to 9, which will not be elaborated here.
[0349] Embodiment 11:
[0350] Referring to Figures 1 to 4 and Figure 17 As shown, the main difference between the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment and those in Embodiment 10 is that in Embodiment 10, the first magnetic member 110 includes at least two first magnets 1111; while in this embodiment, the first magnetic member 110 may be constituted by one first magnet 1111.
[0351] As an implementation manner, in the sample analyzer 10 provided in this embodiment, the orthographic projection of the first magnetic member 110 on the reaction vessel 20 located at the first magnetic adsorption position 1001 is located between the liquid level of the liquid in the reaction vessel 20 and the inner bottom surface of the reaction vessel 20; at least a part of the orthographic projection of the second magnetic member 120 on the reaction vessel 20 located at the first liquid suction position 1002 is located above the liquid level of the liquid in the reaction vessel 20 and / or below the inner bottom surface of the reaction vessel 20. In this way, it can be achieved that when the first magnetic member 110 performs the first magnetic adsorption action, two magnetic bead groups 30 are adsorbed and formed on the inner side wall of the reaction vessel 20 located at the first magnetic adsorption position 1001 and arranged along the height direction of the reaction vessel 20; when the second magnetic member 120 performs the second magnetic adsorption action, a single magnetic bead group 30 is adsorbed and formed on the inner side wall of the reaction vessel 20 located at the first liquid suction position 1002.
[0352] As an implementation manner, the first magnetic member 110 is composed of a first magnetic device 111, the second magnetic member 120 is composed of a second magnetic device 121, the first magnetic device 111 is composed of a first magnet 1111, and the second magnetic device 121 is composed of a second magnet 1211 or two stacked second magnets 1211. Of course, in specific applications, the first magnetic device 111 may also be composed of two or more stacked first magnets 1111.
[0353] In addition to the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference can be made to Embodiments 1 to 10, which will not be elaborated here.
[0354] Embodiment 12:
[0355] Refer to Figures 1 to 4 and Figure 18 As shown, the main difference between the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment and those in Embodiment 1 is that in this embodiment, it is not limited that the first magnetic member 110 adsorbs and forms two magnetic bead groups 30, as long as it is ensured that the distribution area of the magnetic bead groups 30 adsorbed and formed by the first magnetic member 110 is larger than the distribution area of the magnetic bead groups 30 adsorbed and formed by the second magnetic member 120.
[0356] Specifically, the sample analyzer 10 provided in this embodiment includes a sample dispensing mechanism 600, a reagent dispensing mechanism 700, an incubation mechanism 400, a magnetic separation mechanism 100, a measurement mechanism 200, and a controller 300. The sample dispensing mechanism 600 is used to aspirate a sample from a sample container and dispense it into a reaction container 20. The reagent dispensing mechanism 700 is at least used to aspirate a first reagent from a first reagent container and dispense it into the reaction container 20, and the first reagent contains magnetic beads. The incubation mechanism 400 is used to incubate the liquid formed at least by the sample and the first reagent in the reaction container 20. The magnetic separation mechanism 100 is used to perform a magnetic separation operation on the liquid in the reaction container 20 after incubation. The measurement mechanism 200 is used to measure the test liquid prepared at least from the liquid in the reaction container 20 after the magnetic separation operation is completed, and obtain measurement information. The controller 300 is configured to: output the measurement result of the sample according to the measurement information of the measurement mechanism 200.
[0357] As an implementation manner, the magnetic separation mechanism 100 includes a carrying member 140, a scheduling member 150, at least one first liquid suction member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The scheduling member 150 is used to sequentially schedule the reaction container 20 loaded with the incubated liquid along a preset trajectory to a first magnetic attraction position 1001 and a first liquid suction position 1002. The carrying member 140 is at least used to carry the reaction container 20 located at the first magnetic attraction position 1001 and carry the reaction container 20 located at the first liquid suction position 1002. The first magnetic member 110 is used to perform a first magnetic adsorption action on the liquid in the reaction container 20 located at the first magnetic attraction position 1001 to adsorb and form a first magnetic bead group 30 on the inner side wall of the reaction container 20 located at the first magnetic attraction position 1001. The second magnetic member 120 is used to perform a second magnetic adsorption action on the liquid in the reaction container 20 located at the first liquid suction position 1002 to adsorb and form a second magnetic bead group 30 on the inner side wall of the reaction container 20 located at the first liquid suction position 1002. The first liquid suction member 130 is used to perform a first liquid suction action on the liquid in the reaction container 20 located at the first liquid suction position 1002. The adsorption area of the first magnetic bead group on the side wall of the reaction container 20 is larger than the adsorption area of the second magnetic bead group on the side wall of the reaction container 20, that is, the distribution area of the first magnetic bead group is larger than the distribution area of the second magnetic bead group. By adopting the solution of this embodiment, the purpose of making the adsorption speed of the magnetic bead group 30 at the first magnetic attraction position 1001 greater than the adsorption speed at the first liquid suction position 1002 and the purpose of making the adsorption stability of the magnetic bead group 30 at the first liquid suction position 1002 greater than the adsorption stability at the first magnetic attraction position 1001 can also be achieved.
[0358] As an implementation manner, the first magnetic member 110 includes an annular magnet. The enclosed inner sidewall of the annular magnet encloses and forms a first magnetic adsorption position 1001, that is: the first magnetic member 110 includes a single first magnet 1111, and the first magnet 1111 is annular. The second magnetic member 120 is composed of one or two second magnets 1211 distributed on one side of the first liquid absorption position 1002.
[0359] Alternatively, as an alternative implementation, the first magnetic member 110 is composed of a single first magnet 1111 distributed on one side of the first magnetic adsorption position 1001, and the second magnetic member 120 is composed of one second magnet 1211 or two second magnets 1211 distributed on one side of the first liquid absorption position 1002 and stacked vertically. The volume of the first magnetic member 110 is larger than the volume of the second magnetic member 120. For example, the first magnetic member 110 is composed of a semi-circular first magnet 1111, and the second magnetic member 120 is formed by stacking one rectangular second magnet 1211 or two rectangular second magnets 1211.
[0360] A magnetic separation mechanism 100 provided in this embodiment includes a carrier member 140, a scheduling member 150, at least one first liquid absorption member 130, at least one first magnetic member 110, and at least one second magnetic member 120. The scheduling member 150 is used to sequentially schedule the reaction vessel 20 along a preset trajectory to the first magnetic adsorption position 1001 and the first liquid absorption position 1002; the carrier member 140 is at least used to carry the reaction vessel 20 located at the first magnetic adsorption position 1001 and carry the reaction vessel 20 located at the first liquid absorption position 1002; the first magnetic member 110 is used to perform a first magnetic adsorption action on the liquid in the reaction vessel 20 located at the first magnetic adsorption position 1001 to adsorb and form a first magnetic bead group 30 on the inner sidewall of the reaction vessel 20 located at the first magnetic adsorption position 1001; the second magnetic member 120 is used to perform a second magnetic adsorption action on the liquid in the reaction vessel 20 located at the first liquid absorption position 1002 to adsorb and form a second magnetic bead group 30 on the inner sidewall of the reaction vessel 20 located at the first liquid absorption position 1002; the first liquid absorption member 130 is used to perform a first liquid absorption action on the liquid in the reaction vessel 20 located at the first liquid absorption position 1002; the adsorption area of the first magnetic bead group on the sidewall of the reaction vessel 20 is larger than the adsorption area of the second magnetic bead group on the sidewall of the reaction vessel 20, that is, the distribution area of the first magnetic bead group is larger than the distribution area of the second magnetic bead group.
[0361] In addition to the above, for other parts of the sample analyzer 10 and the magnetic separation mechanism 100 provided in this embodiment, reference can be made to Embodiments 1 to 11, which will not be elaborated here.
[0362] The above are only the preferred embodiments of the present invention, and do not limit the patent scope of the present invention accordingly. Any equivalent structural transformation made under the inventive concept of the present invention by using the content of the specification and drawings of the present invention, or any direct / indirect application in other related technical fields, is included in the patent protection scope of the present invention.
Claims
1. A sample analyzer, characterized in that: include: A sample dispensing mechanism, the sample dispensing mechanism is used to draw a sample from a sample container and distribute it into a reaction container; A reagent dispensing mechanism, the reagent dispensing mechanism is at least used to draw a first reagent from a first reagent container and dispense it into the reaction container, wherein the first reagent comprises magnetic beads; A magnetic separation mechanism, the magnetic separation mechanism is used to perform a magnetic separation operation on the liquid in the reaction container, the liquid in the reaction container is formed by at least the sample and the first reagent; A measuring mechanism, the measuring mechanism is used to measure the liquid to be tested in the reaction container, which is at least made of the liquid after the magnetic separation operation, to obtain measurement information; a controller, the controller being configured to: output a measurement result of the sample according to the measurement information of the measurement mechanism; Wherein, the magnetic separation mechanism comprises a bearing member, a scheduling member, at least one first liquid absorption member, at least one first magnetic member and at least one second magnetic member, the first magnetic member comprises two first magnetic devices arranged in pairs and at intervals, a first magnetic attraction position is formed on one side of each of the first magnetic devices, and the first magnetic member is used to perform a first magnetic attraction action on the liquid in the reaction container located at the first magnetic attraction position to form two magnetic bead groups by adsorbing the inner wall of the reaction container located at the first magnetic attraction position; The second magnetic member is composed of a single second magnetic device, a first liquid absorption position is formed on one side of the single second magnetic device, and the second magnetic member is used to perform a second magnetic absorption action on the liquid in the reaction container located at the first liquid absorption position to absorb and form a single magnetic bead group on the inner side wall of the reaction container located at the first liquid absorption position; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The scheduling component is at least used to schedule the reaction container to the first magnetic attraction position, and schedule the reaction container after completing the first magnetic attraction action to the first liquid absorption position.
2. The sample analyzer according to claim 1, characterized in that: The first magnetic attraction position is used to accommodate the reaction container to perform the first magnetic attraction action but not to perform the liquid aspiration action, and the first liquid aspiration position is used to accommodate the reaction container to perform the second magnetic attraction action and the first liquid aspiration action.
3. The sample analyzer according to claim 1, wherein: The first magnetic attraction position is provided with a receiving groove for receiving the reaction container; The two first magnetic components are spaced apart and arranged opposite to each other along the radial direction of the receiving groove; or, The two first magnetic components are spaced apart and arranged up and down along the axial direction of the accommodation groove; or, The two first magnetic components are spaced apart and closely arranged along the circumference of the accommodation groove.
4. The sample analyzer according to claim 1, wherein: The scheduling component is used to drive the bearing component to drive the reaction container to move to the first magnetic suction position and the first liquid suction position in sequence; The two first magnetic devices are respectively arranged on opposite sides of the motion trajectory of the scheduling component driving the reaction container to move or on one side of the motion trajectory of the scheduling component driving the reaction container to move, and the second magnetic device is arranged on one side of the motion trajectory.
5. The sample analyzer according to claim 4, characterized in that: The bearing member is disc-shaped, and is formed with a plurality of accommodating grooves arranged along the circumference of the disc-shaped bearing member, each of the accommodating grooves is used to accommodate a reaction container, and the scheduling member is used to drive the bearing member to drive the reaction container to rotate horizontally around the central axis of the bearing member, so that the reaction container accommodated in the accommodating groove is sequentially scheduled to the first magnetic suction position and the first liquid suction position.
6. The sample analyzer according to claim 4 or 5, characterized in that: The two first magnetic devices are respectively arranged on opposite sides of the motion track; the number of the first magnetic suction positions is at least two, and the number of the first liquid suction positions is at least two; the number of the first magnetic components is at least two and they are arranged in sequence along the motion track, and the number of the second magnetic components is at least two and they are arranged in sequence along the motion track; The magnetic separation mechanism also includes a main bracket, a first mounting frame and a second mounting frame respectively connected to the main bracket, the first mounting frame and the second mounting frame are respectively located on opposite sides of the motion trajectory, the first mounting frame is used to carry all the first magnetic components and all the second magnetic components arranged on one side of the motion trajectory, and the second mounting frame is used to carry all the first magnetic components arranged on the other side of the motion trajectory.
7. The sample analyzer according to claim 4 or 5, characterized in that: All the first magnetic devices are arranged on one side of the motion track, and all the second magnetic devices are also arranged on the same side of the motion track.
8. The sample analyzer according to any one of claims 1 to 5, characterized in that: The first magnetic device is composed of a single first magnet or two adjacent paired first magnets, and the second magnetic device is composed of a single second magnet or two adjacent paired second magnets; One end of the two adjacent paired first magnets close to the first magnetic suction position abuts against each other or one side of the two adjacent paired first magnets contacts each other, and one end of the two adjacent paired second magnets close to the first liquid suction position abuts against each other or one side of the two adjacent paired second magnets contacts each other.
9. The sample analyzer according to claim 8, characterized in that: The two magnetic poles of the same first magnet are arranged in a horizontal direction or a vertical direction; The two magnetic poles of the same second magnet are arranged along the horizontal direction or the vertical direction.
10. The sample analyzer according to claim 9, characterized in that: The first magnetic device is composed of two first magnets stacked in a vertical direction, and the second magnetic device is composed of two second magnets stacked in a vertical direction; or, The first magnetic device is composed of two first magnets stacked in a vertical direction, and the second magnetic device is composed of a single second magnet; or, The first magnetic device is composed of a single first magnet, and the second magnetic device is composed of a single second magnet; or, The first magnetic device is composed of a single first magnet, and the second magnetic device is composed of two second magnets stacked in a vertical direction; or, The first magnetic device is composed of two first magnets abutting against each other in a horizontal direction, and the second magnetic device is composed of two second magnets abutting against each other in a horizontal direction.
11. The sample analyzer according to claim 10, characterized in that: Two of the first magnetic devices are arranged at intervals on opposite sides of the first magnetic attraction position along the horizontal direction; The first magnetic device is composed of two first magnets stacked in a vertical direction, and the second magnetic device is composed of two second magnets stacked in a vertical direction; The two magnetic poles of the same first magnet are arranged in the horizontal direction, and the two magnetic poles of the same second magnet are arranged in the horizontal direction; The polarities of the magnetic poles of the two first magnets stacked in the vertical direction in the same first magnetic device facing the same first magnetic suction position are opposite, and the polarities of the magnetic poles of the two second magnets stacked in the vertical direction in the second magnetic device facing the same first liquid suction position are opposite; In two paired and spaced-apart first magnetic devices of the same first magnetic component, two first magnets distributed on opposite sides of the same first magnetic attraction position and at the same height position have the same polarity of magnetic poles facing the same first magnetic attraction position.
12. The sample analyzer according to any one of claims 1 to 5, characterized in that: The height position of the first magnetic member is lower than the height position of the second magnetic member.
13. The sample analyzer according to any one of claims 1 to 5, characterized in that: At least two first magnetic positions are formed on one side of each first magnetic device and are sequentially distributed along the motion trajectory of the reaction container driven by the scheduling component; and / or, At least two first liquid suction positions are formed on one side of the second magnetic device and are distributed in sequence along a motion trajectory of the reaction container driven by the scheduling component.
14. The sample analyzer according to any one of claims 1 to 5, characterized in that: The magnetic separation mechanism further includes at least one third magnetic member, the third magnetic member is composed of a single third magnetic device, a second magnetic attraction position is formed on one side of the single third magnetic device, and the third magnetic member is used to perform a third magnetic attraction action on the liquid in the reaction container located at the second magnetic attraction position to form a single magnetic bead group by adsorbing the inner side wall of the reaction container located at the second magnetic attraction position; The scheduling component schedules the reaction container after completing the first magnetic adsorption action to the first liquid absorption position, including: first scheduling the reaction container after completing the first magnetic adsorption action to the second magnetic adsorption position, and then scheduling the reaction container after completing the third magnetic adsorption action to the first liquid absorption position.
15. The sample analyzer according to claim 14, characterized in that: The first magnetic attraction position, the second magnetic attraction position and the first liquid absorption position are sequentially distributed along a motion trajectory of the reaction container driven by the scheduling component; The third magnetic device is arranged on one side of the motion track of the scheduling component driving the reaction container to move, and the second magnetic device is also arranged on the same side of the motion track.
16. The sample analyzer according to any one of claims 1 to 5, characterized in that: The magnetic separation mechanism further includes at least one first liquid injection component, at least one mixing component, at least one fourth magnetic component, at least one fifth magnetic component and at least one second liquid absorption component, wherein the fourth magnetic component includes two fourth magnetic devices arranged in pairs and at intervals, and a third magnetic attraction position is formed on one side of each of the fourth magnetic devices, and the fourth magnetic component is used to perform a fourth magnetic attraction action on the liquid in the reaction container located at the third magnetic attraction position to form two magnetic bead groups by adsorbing the inner side wall of the reaction container located at the third magnetic attraction position; The fifth magnetic member is composed of a single fifth magnetic device, a second liquid suction position is formed on one side of the single fifth magnetic device, and the fifth magnetic member is used to perform a fifth magnetic adsorption action on the liquid in the reaction container located at the second liquid adsorption position to adsorb the liquid on the inner side wall of the reaction container located at the second liquid adsorption position to form a single magnetic bead group; The second liquid suction member is used to perform a second liquid suction action on the liquid in the reaction container located at the second liquid suction position; The dispatching member is further used to dispatch the reaction container after completing the first liquid aspiration action to the first liquid injection position, the mixing position, the third magnetic suction position, and the second liquid aspiration position in sequence, and the carrying member is further used to carry the reaction container at the first liquid injection position, the reaction container at the mixing position, the reaction container at the third magnetic suction position, and the reaction container at the second liquid aspiration position; The first liquid injection member is used to perform a first liquid injection action of injecting a cleaning liquid into the reaction container located at the first liquid injection position and after completing the first liquid aspiration action; The mixing component is used to perform a mixing action on the reaction container located at the mixing position and after completing the first liquid injection action; Among them, the third magnetic suction position and the first magnetic suction position are located at two different positions or at the same position, the second liquid suction position and the first liquid suction position are located at two different positions or at the same position, and the first liquid injection position and the first liquid suction position are located at two different positions or at the same position.
17. The sample analyzer according to claim 16, wherein: The magnetic separation mechanism also includes at least one sixth magnetic component, the sixth magnetic component is composed of a single sixth magnetic device, a fourth magnetic attraction position is formed on one side of the single sixth magnetic device, the sixth magnetic component is used to perform a sixth magnetic attraction action on the liquid in the reaction container located at the fourth magnetic attraction position to adsorb the inner wall of the reaction container located at the fourth magnetic attraction position to form a single magnetic bead group, the carrying component is also used to carry the reaction container located at the fourth magnetic attraction position, and the scheduling component schedules the reaction container after completing the fourth magnetic attraction action at the third magnetic attraction position to the second liquid absorption position, including: first scheduling the reaction container after completing the fourth magnetic attraction action at the third magnetic attraction position to the fourth magnetic attraction position, and then scheduling the reaction container after completing the sixth magnetic attraction action at the fourth magnetic attraction position to the second liquid absorption position; and / or, The magnetic separation mechanism also includes at least one seventh magnetic component, at least one second liquid injection component and at least one third liquid suction component, the seventh magnetic component is composed of a single seventh magnetic device, and a third liquid suction position is formed on one side of the single seventh magnetic device. The seventh magnetic component is used to perform a seventh magnetic adsorption action on the liquid in the reaction container located at the third liquid suction position to adsorb the inner wall of the reaction container located at the third liquid suction position to form a single magnetic bead group, the scheduling component is also used to schedule the reaction container after completing the second liquid suction action to the second liquid injection position and the third liquid suction position in sequence, the carrying component is also used to carry the reaction container located at the second liquid injection position and the reaction container located at the third liquid suction position, the second liquid injection component is used to perform a second liquid injection action of injecting cleaning liquid into the reaction container located at the second liquid injection position and after completing the second liquid suction action, and the third liquid suction component is used to perform a third liquid suction action on the liquid in the reaction container located at the third liquid suction position, wherein the second liquid injection position and the second liquid suction position are located at two different positions or at the same position.
18. A sample analyzer, characterized in that: include: A sample dispensing mechanism, the sample dispensing mechanism is used to draw a sample from a sample container and distribute it into a reaction container; A reagent dispensing mechanism, the reagent dispensing mechanism is at least used to draw a first reagent from a first reagent container and dispense it into the reaction container, wherein the first reagent comprises magnetic beads; a magnetic separation mechanism, the magnetic separation mechanism being used to perform a magnetic separation operation on the liquid in the reaction container, the liquid in the reaction container being formed by the sample and the first reagent; A measuring mechanism, the measuring mechanism is used to measure the liquid to be tested in the reaction container, which is at least made of the liquid after the magnetic separation operation, to obtain measurement information; a controller, the controller being configured to: output a measurement result of the sample according to the measurement information of the measurement mechanism; Wherein, the magnetic separation mechanism includes a bearing member, a scheduling member, at least one first liquid absorption member, at least one first magnetic member and at least one second magnetic member, the first magnetic member is composed of a single first magnetic device, the single first magnetic device is composed of at least three first magnets stacked in a vertical direction or at least three first magnets abutted in sequence in a horizontal direction, a first magnetic suction position is formed on one side of the single first magnetic device, and the first magnetic member is used to perform a first magnetic suction action on the liquid in the reaction container located at the first magnetic suction position to absorb and form at least two magnetic bead groups on the inner side wall of the reaction container located at the first magnetic suction position; The second magnetic member is composed of a single second magnetic device, which is composed of one second magnet or at least two second magnets abutting in sequence in the horizontal direction or at least two second magnets stacked in the vertical direction, the number of the first magnets contained in the single first magnetic device is greater than the number of the second magnets contained in the single second magnetic device, a first liquid suction position is formed on one side of the single second magnetic device, and the second magnetic member is used to perform a second magnetic suction action on the liquid in the reaction container located at the first liquid suction position to absorb and form at least one magnetic bead group on the inner side wall of the reaction container located at the first magnetic suction position; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The scheduling component is at least used to schedule the reaction container loaded with the liquid to the first magnetic attraction position, and schedule the reaction container after completing the first magnetic attraction action to the first liquid absorption position.
19. The sample analyzer according to claim 18, wherein: The first magnetic device is composed of at least three first magnets stacked in a vertical direction, and the second magnetic device is composed of a single second magnet or two second magnets stacked in a vertical direction; or, The first magnetic device is composed of at least three first magnets abutting against each other in sequence along a horizontal direction, and the second magnetic device is composed of a single second magnet or two second magnets abutting against each other in a horizontal direction.
20. The sample analyzer according to claim 18 or 19, characterized in that: The scheduling component is used to drive the bearing component to drive the reaction container loaded with the liquid to move to the first magnetic suction position and the first liquid suction position in sequence; The first magnetic device and the second magnetic device are arranged on the same side of the motion track of the scheduling component driving the reaction container to move; Preferably, the bearing member is disc-shaped, and is formed with a plurality of accommodating grooves arranged along the circumference of the disc-shaped bearing member, each of the accommodating grooves is used to accommodate a reaction container, and the scheduling member is used to drive the bearing member to drive the reaction container to rotate horizontally around the central axis of the bearing member, so that the reaction container accommodated in the accommodating groove is sequentially scheduled to the first magnetic suction position and the first liquid suction position.
21. A sample analyzer, characterized in that: include: A sample dispensing mechanism, the sample dispensing mechanism is used to draw a sample from a sample container and distribute it into a reaction container; A reagent dispensing mechanism, the reagent dispensing mechanism is at least used to draw a first reagent from a first reagent container and dispense it into the reaction container, wherein the first reagent comprises magnetic beads; A magnetic separation mechanism, the magnetic separation mechanism is used to perform a magnetic separation operation on the liquid in the reaction container, the liquid in the reaction container is formed by the sample and the first reagent; A measuring mechanism, the measuring mechanism is used to measure the liquid to be tested in the reaction container, which is at least made of the liquid after the magnetic separation operation, to obtain measurement information; a controller, the controller being configured to: output a measurement result of the sample according to the measurement information of the measurement mechanism; The magnetic separation mechanism comprises a bearing member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member, wherein the first magnetic member comprises at least two first magnets arranged at intervals, a first magnetic attraction position is formed between the at least two first magnets arranged at intervals, and the first magnetic member is used to perform a first magnetic attraction action on the liquid in the reaction container located at the first magnetic attraction position; The second magnetic member is composed of one second magnet or at least two second magnets, a first liquid suction position is formed on one side of the one second magnet or one side of the at least two second magnets or between the at least two second magnets, the second magnetic member is used to perform a second magnetic suction action on the liquid in the reaction container located at the first liquid suction position, and the number of the first magnets included in one first magnetic member is greater than the number of the second magnets included in one second magnetic member; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The scheduling component is at least used to schedule the reaction container loaded with the liquid to the first magnetic attraction position, and schedule the reaction container after completing the first magnetic attraction action to the first liquid absorption position.
22. The sample analyzer according to claim 21, characterized in that: The first magnetic member is composed of four first magnets, and the four first magnets are arranged in pairs on opposite sides of the first magnetic suction position; the second magnetic member is composed of one second magnet arranged on one side of the first liquid suction position, or is composed of two second magnets stacked on one side of the first liquid suction position, or is composed of two second magnets arranged on one side of the first liquid suction position in a horizontal direction and abutting against each other; or The first magnetic component is composed of two first magnets, and the two first magnets are respectively arranged on opposite sides of the first magnetic suction position; the second magnetic component is composed of one second magnet arranged on one side of the first liquid suction position or two second magnets stacked on one side of the first liquid suction position or two second magnets arranged on one side of the first liquid suction position in a horizontal direction and abutting each other.
23. A sample analyzer, characterized in that: include: A sample dispensing mechanism, the sample dispensing mechanism is used to draw a sample from a sample container and distribute it into a reaction container; A reagent dispensing mechanism, the reagent dispensing mechanism is at least used to draw a first reagent from a first reagent container and dispense it into the reaction container, wherein the first reagent comprises magnetic beads; A magnetic separation mechanism, which is used to perform a magnetic separation operation on the liquid in the reaction container; A measuring mechanism, the measuring mechanism is used to measure the liquid to be tested in the reaction container, which is at least made of the liquid after the magnetic separation operation, to obtain measurement information; a controller, the controller being configured to: output a measurement result of the sample according to the measurement information of the measurement mechanism; The magnetic separation mechanism comprises a bearing member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member, and the scheduling member is used to sequentially schedule the reaction container loaded with the liquid to the first magnetic suction position and the first liquid suction position along a preset trajectory; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The first magnetic member is used to perform a first magnetic attraction action on the liquid in the reaction container located at the first magnetic attraction position to form a first number of magnetic beads by adsorbing the inner wall of the reaction container located at the first magnetic attraction position; The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction container located at the first liquid aspiration position to adsorb and form a second number of magnetic bead clusters on the inner wall of the reaction container located at the first liquid aspiration position; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The first number is greater than or equal to two, and the first number is greater than the second number.
24. The sample analyzer according to claim 23, characterized in that: When the first magnetic member performs the first magnetic adsorption action, the inner wall of the reaction container located at the first magnetic adsorption position is adsorbed to form at least two magnetic bead clusters arranged along the circumferential direction of the reaction container; when the second magnetic member performs the second magnetic adsorption action, the inner wall of the reaction container located at the first liquid absorption position is adsorbed to form a single magnetic bead cluster; and / or, The first magnetic member includes at least two first magnets arranged in a horizontal circumferential direction with an interval, and the second magnetic member is composed of a single second magnet or two second magnets stacked in a vertical direction.
25. The sample analyzer according to claim 23 or 24, characterized in that: When the first magnetic member performs the first magnetic adsorption action, the inner wall of the reaction container located at the first magnetic adsorption position is adsorbed to form at least two magnetic bead clusters arranged along the height direction of the reaction container; when the second magnetic member performs the second magnetic adsorption action, the inner wall of the reaction container located at the first liquid absorption position is adsorbed to form a single magnetic bead cluster; and / or, The first magnetic member includes at least three first magnets stacked in a vertical direction, and the second magnetic member is composed of a single second magnet or two second magnets stacked in a vertical direction.
26. The sample analyzer according to claim 23, characterized in that: The orthographic projection of the first magnetic member on the reaction container located at the first magnetic attraction position is located between the liquid surface of the liquid in the reaction container and the inner bottom surface of the reaction container; At least a portion of the orthographic projection of the second magnetic member on the reaction container located at the first liquid aspiration position is located above the liquid level of the reaction container and / or below the inner bottom surface of the reaction container.
27. The sample analyzer according to claim 23, 24 or 26, characterized in that: The height position of the magnetic bead cluster formed by the first magnetic member adsorbing on the inner wall of the reaction container when the first magnetic member performs the first magnetic adsorption action is lower than the height position of the magnetic bead cluster formed by the second magnetic member adsorbing on the inner wall of the reaction container when the second magnetic member performs the second magnetic adsorption action; and / or, The height position of the first magnetic member is lower than the height position of the second magnetic member.
28. The sample analyzer according to claim 23, 24 or 26, characterized in that: The first magnetic component is composed of one first magnetic device or at least two first magnetic devices arranged at intervals, the second magnetic component is composed of one second magnetic device or at least two second magnetic devices arranged at intervals, the first magnetic device is composed of at least one first magnet, and the second magnetic device is composed of at least one second magnet; and the number of the first magnets contained in one first magnetic device is greater than or equal to the number of the second magnets contained in the second magnetic device or is one less than the number of the second magnets contained in the second magnetic device.
29. The sample analyzer according to claim 28, characterized in that: The first magnetic component is composed of a single first magnetic device, the second magnetic component is composed of at least two second magnetic devices arranged at intervals, the first magnetic device is composed of at least four first magnets stacked in the vertical direction or abutted in sequence in the horizontal direction, the second magnetic device is composed of a single second magnet or two second magnets stacked in the vertical direction or abutted against each other in the horizontal direction, and the number of the first magnets included in the first magnetic component is at least two more than the number of the second magnetic devices included in the second magnetic component.
30. The sample analyzer according to claim 28, wherein: The first magnetic member is composed of at least two first magnetic components arranged at intervals, and the second magnetic member is composed of a single second magnetic component; or, The first magnetic component is composed of at least two first magnetic devices arranged at intervals, the second magnetic component is composed of at least two second magnetic devices arranged at intervals, the first magnetic device is composed of a single first magnet or at least two first magnets stacked in the vertical direction or abutted in sequence in the horizontal direction, the second magnetic device is composed of a single second magnet or at least two second magnets stacked in the vertical direction or abutted in sequence in the horizontal direction, and the first parameter of one of the following two parameter groups of the first magnetic component and the second magnetic component is greater than the latter parameter, and the first parameter of the other parameter group is greater than or equal to the latter parameter: the number of the first magnetic devices and the number of the second magnetic devices, the spacing distance between two adjacent first magnetic devices in the same first magnetic component and the spacing distance between two adjacent second magnetic devices in the same second magnetic component.
31. The sample analyzer according to claim 30, wherein: The first magnetic member is composed of at least three first magnetic components arranged at intervals, the second magnetic member is composed of two second magnetic components arranged at intervals, and the interval between two adjacent first magnetic components in the same first magnetic member is greater than or equal to the interval between two adjacent second magnetic components in the same second magnetic member; or The first magnetic component is composed of two first magnetic devices arranged at intervals, and the second magnetic component is composed of two second magnetic devices arranged at intervals. The spacing distance between two adjacent first magnetic devices in the same first magnetic component is greater than the spacing distance between two adjacent second magnetic devices in the same second magnetic component.
32. A sample analyzer, characterized in that: include: A sample dispensing mechanism, the sample dispensing mechanism is used to draw a sample from a sample container and distribute it into a reaction container; A reagent dispensing mechanism, the reagent dispensing mechanism is at least used to draw a first reagent from a first reagent container and dispense it into the reaction container, wherein the first reagent comprises magnetic beads; A magnetic separation mechanism, the magnetic separation mechanism is used to perform a magnetic separation operation on the liquid in the reaction container, the liquid in the reaction container is formed by at least the sample and the first reagent; A measuring mechanism, the measuring mechanism is used to measure the liquid to be tested in the reaction container, which is at least made of the liquid after the magnetic separation operation, to obtain measurement information; a controller, the controller being configured to: output a measurement result of the sample according to the measurement information of the measurement mechanism; The magnetic separation mechanism comprises a bearing member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member, and the scheduling member is used to sequentially schedule the reaction container loaded with the liquid to the first magnetic suction position and the first liquid suction position along a preset trajectory; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The first magnetic member is used to perform a first magnetic attraction action on the liquid in the reaction container located at the first magnetic attraction position so as to form a first magnetic bead group by adsorption on the inner side wall of the reaction container located at the first magnetic attraction position; The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction container located at the first liquid aspiration position so as to form a second magnetic bead cluster by adsorption on the inner wall of the reaction container located at the first liquid aspiration position; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The adsorption area of the first magnetic bead group on the side wall of the reaction container is larger than the adsorption area of the second magnetic bead group on the side wall of the reaction container.
33. The sample analyzer according to claim 32, wherein: The first magnetic component comprises an annular magnet, the closed inner side wall of the annular magnet encloses the first magnetic suction position, and the second magnetic component is composed of one or two second magnets distributed on one side of the first liquid suction position; or, The first magnetic component is composed of a single first magnet distributed on a single side of the first magnetic suction position, and the second magnetic component is composed of one second magnet or two second magnets distributed on a single side of the first liquid suction position and stacked in a vertical direction. The volume of the first magnetic component is greater than that of the second magnetic component.
34. A magnetic separation mechanism, characterized in that: The invention comprises a bearing member, a scheduling member, at least one first liquid-absorbing member, at least one first magnetic member and at least one second magnetic member, wherein the first magnetic member comprises two first magnetic devices arranged in pairs and at intervals, a first magnetic attraction position is formed on one side of each of the first magnetic devices, and the first magnetic member is used to perform a first magnetic attraction action on the liquid in the reaction container located at the first magnetic attraction position to form two magnetic bead groups by adsorbing the inner side wall of the reaction container located at the first magnetic attraction position; The second magnetic member is composed of a single second magnetic device, a first liquid absorption position is formed on one side of the single second magnetic device, and the second magnetic member is used to perform a second magnetic absorption action on the liquid in the reaction container located at the first liquid absorption position to absorb and form a single magnetic bead group on the inner side wall of the reaction container located at the first liquid absorption position; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The scheduling component is at least used to schedule the reaction container to the first magnetic attraction position, and schedule the reaction container after completing the first magnetic attraction action to the first liquid absorption position.
35. A magnetic separation mechanism, characterized in that: The invention comprises a bearing member, a scheduling member, at least one first liquid absorption member, at least one first magnetic member and at least one second magnetic member, wherein the first magnetic member is composed of a single first magnetic device, and the single first magnetic device is composed of at least three first magnets stacked in a vertical direction or at least three first magnets abutted in sequence in a horizontal direction, and a first magnetic attraction position is formed on one side of the single first magnetic device, and the first magnetic member is used to perform a first magnetic attraction action on the liquid in the reaction container located at the first magnetic attraction position to absorb and form at least two magnetic bead groups on the inner side wall of the reaction container located at the first magnetic attraction position; The second magnetic member is composed of a single second magnetic device, which is composed of one second magnet or at least two second magnets abutting in sequence in the horizontal direction or at least two second magnets stacked in the vertical direction, the number of the first magnets contained in the single first magnetic device is greater than the number of the second magnets contained in the single second magnetic device, a first liquid suction position is formed on one side of the single second magnetic device, and the second magnetic member is used to perform a second magnetic suction action on the liquid in the reaction container located at the first liquid suction position to absorb and form at least one magnetic bead group on the inner side wall of the reaction container located at the first magnetic suction position; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The scheduling component is at least used to schedule the reaction container to the first magnetic attraction position, and schedule the reaction container after completing the first magnetic attraction action to the first liquid absorption position.
36. A magnetic separation mechanism, characterized in that: The invention comprises a bearing member, a scheduling member, at least one first liquid-absorbing member, at least one first magnetic member and at least one second magnetic member, wherein the first magnetic member comprises at least two first magnets arranged at intervals, a first magnetic attraction position is formed between the at least two first magnets arranged at intervals, and the first magnetic member is used to perform a first magnetic attraction action on the liquid in the reaction container located at the first magnetic attraction position; The second magnetic member is composed of one second magnet or at least two second magnets, a first liquid suction position is formed on one side of the one second magnet or one side of the at least two second magnets or between the at least two second magnets, the second magnetic member is used to perform a second magnetic suction action on the liquid in the reaction container located at the first liquid suction position, and the number of the first magnets included in one first magnetic member is greater than the number of the second magnets included in one second magnetic member; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The scheduling component is at least used to schedule the reaction container to the first magnetic attraction position, and schedule the reaction container after completing the first magnetic attraction action to the first liquid absorption position.
37. A magnetic separation mechanism, characterized in that: It comprises a bearing member, a scheduling member, at least one first liquid suction member, at least one first magnetic member and at least one second magnetic member, wherein the scheduling member is used to sequentially schedule the reaction container to a first magnetic suction position and a first liquid suction position along a preset trajectory; The bearing member is at least used for bearing the reaction container located at the first magnetic suction position and the reaction container located at the first liquid suction position; The first magnetic member is used to perform a first magnetic attraction action on the liquid in the reaction container located at the first magnetic attraction position to form a first number of magnetic beads by adsorbing the inner wall of the reaction container located at the first magnetic attraction position; The second magnetic member is used to perform a second magnetic adsorption action on the liquid in the reaction container located at the first liquid aspiration position to adsorb and form a second number of magnetic bead clusters on the inner wall of the reaction container located at the first liquid aspiration position; The first liquid suction member is used to perform a first liquid suction action on the liquid in the reaction container located at the first liquid suction position; The first number is greater than or equal to two, and the first number is greater than the second number.