Energy storage device, sample analysis system and liquid chromatography analyzer

Abstract

The invention is applicable to the field of in-vitro diagnostic equipment, and discloses an energy storage device, a sample analysis system and a liquid chromatographic analyzer. The energy storage device comprises an energy storage device and a locking and releasing device, the energy storage device comprises a shell and a potential energy storage and release assembly, and the potential energy storage and release assembly is at least partially arranged in the shell and is divided in the shell to form a liquid cavity for liquid-phase fluid to flow through; at least part of the potential energy storage and release assembly can move relative to the shell to change the size of the liquid cavity and store potential energy or release the stored potential energy; the locking and releasing device can be switched between a locking state and a releasing state; in the locking state, the locking and releasing device applies acting force to the potential energy storing and releasing assembly so as to lock the potential energy storing and releasing assembly; in the release state, the potential energy storage and release assembly stores potential energy, and under the condition that the locking and releasing device removes the acting force applied to the potential energy storage and release assembly, the potential energy storage and release assembly is allowed to release the stored potential energy. The method can be used for solving the technical problems of low utilization efficiency and low detection speed of the liquid-phase fluid.

Description

[0001] This application is a divisional application of the invention patent application (application date: December 29, 2023, application number: 2023118731119). Technical Field

[0002] The present invention relates to the field of in vitro diagnostic devices, and in particular, to an energy storage device, a sample analysis system having the energy storage device, and a liquid chromatography analyzer having the energy storage device. Background Art

[0003] The normal working process of a liquid chromatography analyzer provided by the related art is as follows: First, a driving device is used to drive the pressure of the liquid phase fluid to reach a target pressure value or a target pressure range to achieve pressure building, and then the chromatographic analysis item is started. After the chromatographic analysis item is completed, if there is no sample to perform the chromatographic analysis item, the driving device is stopped to achieve pressure relief.

[0004] When the above liquid chromatography analyzer is applied to a scenario that requires frequent and intermittent sample injection, the liquid path system needs to frequently repeat the processes of pressure building, performing the chromatographic analysis item, and pressure relief. As a result, the following problems exist in the specific application of the liquid chromatography analyzer: (1) Frequent pressure building and pressure relief will cause loss of the liquid phase fluid, and thus the utilization efficiency of the liquid phase fluid is relatively low; (2) The pressure building process takes a relatively long time, and repeated pressure building results in a relatively slow detection speed of the liquid chromatography analyzer in the scenario of intermittent sample injection. Therefore, it is difficult for the liquid chromatography analyzer to be connected to other analyzers for other analysis items. Because when the liquid chromatography analyzer is connected to other analyzers, the pressure building process will cause the sample to stay on the track, thus blocking the sample transfer channel of other analyzers and reducing the detection efficiency of the sample. Based on this, the liquid chromatography analyzer generally operates in a stand-alone mode, and it is recommended that the operator perform centralized sample injection on the stand-alone liquid chromatography analyzer to reduce the processes of pressure building and pressure relief. In this way, the time for issuing the detection report of the chromatographic analysis item of some samples will be relatively long, which is likely to cause dissatisfaction among patients. Summary of the Invention

[0005] The first object of the present invention is to provide an energy storage device, which aims to solve the technical problems in the related art that the utilization efficiency of the liquid phase fluid is low and the detection speed is slow due to the inability of the liquid path of the liquid phase fluid to store energy.

[0006] To achieve the above object, the solution provided by the present invention is: An energy storage device, comprising:

[0007] Energy storage device, the energy storage device includes a housing and a potential energy storage and release component, at least part of the potential energy storage and release component is arranged in the housing and partitions a liquid cavity for a liquid-phase fluid to flow through in the housing, and at least part of the potential energy storage and release component can move relative to the housing to change the size of the liquid cavity and store potential energy or release the stored potential energy;

[0008] Locking and releasing device, the locking and releasing device can switch between a locked state and a released state: in the locked state, the locking and releasing device applies a force to the potential energy storage and release component to lock the potential energy storage and release component, thereby preventing the potential energy storage and release component from moving relative to the housing and preventing the potential energy storage and release component from releasing the stored potential energy; in the released state, the potential energy storage and release component can move relative to the housing under the pressure of the liquid-phase fluid to store potential energy, and, when the locking and releasing device removes the force applied to the potential energy storage and release component, the potential energy storage and release component is released, thereby allowing the potential energy storage and release component to move relative to the housing to allow the potential energy storage and release component to release the stored potential energy.

[0009] As an implementation, the potential energy stored and released by the potential energy storage and release component is elastic potential energy; or,

[0010] The potential energy stored and released by the potential energy storage and release component is gravitational potential energy; or,

[0011] The potential energy stored and released by the potential energy storage and release component is gas internal energy.

[0012] As an implementation, the locking and releasing device applies the force to the potential energy storage and release component to lock the potential energy storage and release component by abutting against the potential energy storage and release component, and the locking and releasing device removes the force applied to the potential energy storage and release component to release the potential energy storage and release component by disengaging from the potential energy storage and release component.

[0013] As an implementation, the locking and releasing device applies the force to the potential energy storage and release component to lock the potential energy storage and release component by non-liquid path locking, and the locking and releasing device removes the force applied to the potential energy storage and release component to release the potential energy storage and release component by non-liquid path conduction.

[0014] As an implementation, the potential energy storage and release component has a clamping portion extending outside the housing, and the locking and releasing device applies the force to the potential energy storage and release component to lock the potential energy storage and release component by limiting the clamping portion;

[0015] The locking and releasing device removes the force applied to the potential energy storage and release component to release the potential energy storage and release component by releasing the clamping portion.

[0016] As an implementation manner, the locking and releasing device includes a power component, a locking component, and a transmission component that is transmission-connected between the power component and the locking component;

[0017] When the locking and releasing device is in the locked state, the locking component is in a locked position to lock the potential energy storage and release assembly. At the locked position, the locking component abuts against the potential energy storage and release assembly.

[0018] As an implementation manner, the transmission component has a self-locking ability. When the locking and releasing device is in the locked state, the power component is in a stopped operating state, and the locking component is maintained in the locked position to lock the potential energy storage and release assembly by the locking force generated by the self-locking of the transmission component.

[0019] As an implementation manner, the power component is a motor;

[0020] When the locking and releasing device is in the locked state, the motor is in a stopped operating state, and the locking component is maintained in the locked position to lock the potential energy storage and release assembly by the locking force generated by the self-locking of the transmission component;

[0021] When the locking and releasing device is in the released state, the motor is in a stopped operating state, and the locking component is in an unlocked position to release the potential energy storage and release assembly. At the unlocked position, the locking component disengages from the potential energy storage and release assembly;

[0022] During the process of the locking and releasing device switching from the locked state to the released state, the motor is in an operating state to drive the locking component to move from the locked position to the unlocked position through the transmission component;

[0023] During the process of the locking and releasing device switching from the released state to the locked state, the motor is in an operating state to drive the locking component to move from the unlocked position to the locked position through the transmission component.

[0024] As an implementation manner, the potential energy storage and release assembly has a latching portion extending outside the housing, and the latching portion has a latching end face facing the liquid chamber;

[0025] The locking component is formed with a locking portion, and the locking portion is used to move between the locked position and the unlocked position under the drive of the power component and the transmission component;

[0026] When the power component starts and operates to drive the transmission component to drive the locking portion to move from the unlocked position to the locked position, the locking portion abuts against the latching end face;

[0027] After the locking part moves to the locking position, the power component stops operating so that the locking part is held at the locking position under the action of the locking force generated by the self-locking of the transmission component;

[0028] When the power component starts and operates to drive the transmission component to drive the locking part to move from the locking position to the unlocking position, the locking part disengages from the clamping end face, so that the potential energy storage and release component releases the stored potential energy and moves towards the liquid cavity to drive the liquid-phase fluid in the liquid cavity to flow out of the liquid cavity.

[0029] As an implementation manner, the locking and releasing device further includes a detection component, and the detection component is used to detect whether the locking part is located at the locking position;

[0030] During the process that the power component drives the transmission component to drive the locking part to move from the unlocking position to the locking position, when the detection component detects that the locking part moves to the locking position, the power component stops operating.

[0031] As an implementation manner, the detection component is a reflective photoelectric sensor or an opposed photoelectric sensor or a proximity switch.

[0032] As an implementation manner, the potential energy stored and released by the potential energy storage and release component is elastic potential energy;

[0033] The potential energy storage and release component includes a diaphragm, an elastic element and a guide rod. The diaphragm is arranged in the shell and cooperates with the inner wall of the shell to form the liquid cavity. One end of the guide rod is connected to the diaphragm, and the other end of the guide rod extends outside the shell and is formed with the clamping part. The elastic element is located in the shell and sleeved on the guide rod;

[0034] The locking and releasing device being in the locked state includes: the locking part abuts against the clamping part to lock the clamping part, so that the elastic element stores the elastic potential energy;

[0035] The locking and releasing device being in the released state includes: the locking part disengages from the clamping part to release the clamping part, so that the elastic element releases the elastic potential energy.

[0036] As an implementation manner, the stiffness of the elastic element is greater than or equal to 500 N / mm and less than or equal to 30,000 N / mm; and / or,

[0037] The elastic element includes at least a pair of disc spring groups.

[0038] As an embodiment, the transmission component includes a screw transmission pair, and the thread lead angle of the screw transmission pair is smaller than the equivalent friction angle; and / or,

[0039] The transmission component comprises a screw transmission pair, and the screw transmission pair is a trapezoidal screw transmission pair.

[0040] A second object of the present invention is to provide an energy storage device, the energy storage device comprising:

[0041] An energy storage device, the energy storage device comprising a shell and a potential energy storage and release component, the potential energy storage and release component is at least partially disposed in the shell and is separated in the shell to form a liquid cavity for a liquid phase fluid to flow through, and at least partially the potential energy storage and release component can move relative to the shell to change the size of the liquid cavity and store potential energy or release the stored potential energy;

[0042] A locking and releasing device, which can be switched between a locked state and a released state: in the locked state, the locking and releasing device abuts against the potential energy storage and release component to lock the potential energy storage and release component, thereby preventing it from moving relative to the shell, so as to prevent the potential energy storage and release component from releasing the stored potential energy; in the released state, the potential energy storage and release component can move relative to the shell through the pressure of the liquid fluid to store potential energy, and, when the locking and releasing device is separated from the potential energy storage and release component, the potential energy storage and release component is released, thereby allowing the potential energy storage and release component to move relative to the shell, so as to allow the potential energy storage and release component to release the stored potential energy.

[0043] As an embodiment, the potential energy storage and release component has a latching portion extending outside the shell, the locking and releasing device locks the potential energy storage and release component by abutting and limiting the latching portion, and the locking and releasing device releases the potential energy storage and release component by disengaging to release the latching portion; and / or,

[0044] The locking and releasing device comprises a power component, a locking component and a transmission component which is transmission-connected between the power component and the locking component, wherein the transmission component has a self-locking capability. When the locking and releasing device is in the locked state, the power component is in a stopped state, and the locking component is in a locked position by a locking force generated by the self-locking of the transmission component to abut and lock the potential energy storage and release component.

[0045] A third object of the present invention is to provide an energy storage device, comprising:

[0046] An energy storage device, the energy storage device comprising a shell and a potential energy storage and release component, the potential energy storage and release component is at least partially disposed in the shell and is separated in the shell to form a liquid cavity for a liquid phase fluid to flow through, and at least partially the potential energy storage and release component can move relative to the shell to change the size of the liquid cavity and store potential energy or release the stored potential energy;

[0047] A locking and releasing device, which can be switched between a locked state and a released state: in the locked state, the locking and releasing device locks the potential energy storage and release component by a non-liquid path locking method, thereby preventing it from moving relative to the shell, so as to prevent the potential energy storage and release component from releasing the stored potential energy; in the released state, the potential energy storage and release component can move relative to the shell through the pressure of the liquid phase fluid to store potential energy, and the locking and releasing device releases the potential energy storage and release component by a non-liquid path conduction method, thereby allowing the potential energy storage and release component to release the stored potential energy.

[0048] As an embodiment, the potential energy storage and release component has a latching portion extending outside the shell, the locking and releasing device locks the potential energy storage and release component by abutting and limiting the latching portion, and the locking and releasing device releases the potential energy storage and release component by disengaging to release the latching portion; and / or,

[0049] The locking and releasing device comprises a power component, a locking component and a transmission component which is transmission-connected between the power component and the locking component, wherein the transmission component has a self-locking capability. When the locking and releasing device is in the locked state, the power component is in a stopped state, and the locking component is in a locked position by a locking force generated by the self-locking of the transmission component to abut and lock the potential energy storage and release component.

[0050] A fourth object of the present invention is to provide a sample analysis system, the sample analysis system comprising:

[0051] A sample input device, the sample input device is at least used for receiving a sample container loaded with a blood sample, so as to achieve the loading of the blood sample;

[0052] A liquid chromatograph analyzer, the liquid chromatograph analyzer is used to draw a blood sample from a sample container and perform chromatographic analysis on at least a portion of the drawn blood sample;

[0053] A blood cell analyzer, the blood cell analyzer is used to draw a blood sample from a sample container and perform a blood cell analysis on at least a portion of the drawn blood sample;

[0054] A sample transfer device, which includes a first transfer track and a second transfer track. The first transfer track is used to transfer a sample container from the sample input device to the liquid chromatography analyzer, and the second transfer track is used to transfer a sample container from the sample input device to the blood cell analyzer. The first transfer track and the second transfer track are integrally formed or connected to each other;

[0055] An information acquisition device, which is used to acquire information characterizing the type of test item of the blood sample in the sample container;

[0056] A control component, which is configured to: determine the type of test item of the blood sample in the sample container according to the information characterizing the type of test item of the blood sample in the sample container fed back by the information acquisition device; and control the sample transfer device to transfer the sample container to the liquid chromatography analyzer and / or the blood cell analyzer for sampling according to the type of test item of the blood sample in the sample container;

[0057] Wherein, the liquid chromatography analyzer includes a sample supply component, a liquid phase fluid supply component, a switching valve, a sample liquid preparation channel, a chromatography column and a detector. The chromatography column is connected between the switching valve and the detector. The switching valve has a switchable first connection state and a second connection state: in the first connection state, the switching valve connects the sample supply component and the sample liquid preparation channel and connects the liquid phase fluid supply component and the chromatography column; in the second connection state, the switching valve connects the liquid phase fluid supply component, the sample liquid preparation channel and the chromatography column;

[0058] The sample supply component is used to suck the blood sample from the sample container and supply a first sample liquid made of at least part of the sucked blood sample to the sample liquid preparation channel through the switching valve;

[0059] The liquid phase fluid supply component is used to drive the first sample liquid in the sample liquid preparation channel to be transported to the chromatography column by the liquid phase fluid, and is used to drive the liquid phase fluid to flow through the switching valve and the chromatography column in sequence;

[0060] The chromatography column is used to adsorb the first sample liquid and is used to allow the liquid phase fluid to elute the first sample liquid to form a test liquid;

[0061] The detector is used to perform chromatographic analysis on the test liquid flowing out of the chromatography column;

[0062] The liquid-phase fluid supply assembly includes a first driving device and the above-described energy storage device. The first driving device is used to drive the liquid-phase fluid to flow towards the switching valve and the chromatography column. The energy storage device is disposed between the first driving device and the switching valve.

[0063] The fifth object of the present invention is to provide a liquid chromatography analyzer, which includes a sample supply assembly, a liquid-phase fluid supply assembly, a switching valve, a sample liquid preparation channel, a chromatography column, and a detector. The chromatography column is connected between the switching valve and the detector. The switching valve has a switchable first connection state and a second connection state: in the first connection state, the switching valve connects the sample supply assembly and the sample liquid preparation channel and connects the liquid-phase fluid supply assembly and the chromatography column; in the second connection state, the switching valve connects the liquid-phase fluid supply assembly, the sample liquid preparation channel, and the chromatography column.

[0064] The sample supply assembly is used to suck a blood sample from a sample container and supply a first sample liquid made of at least a part of the sucked blood sample to the sample liquid preparation channel through the switching valve.

[0065] The liquid-phase fluid supply assembly is used to drive the first sample liquid in the sample liquid preparation channel to be transported to the chromatography column by the liquid-phase fluid, and is used to drive the liquid-phase fluid to flow through the switching valve and the chromatography column in sequence.

[0066] The chromatography column is used to adsorb the first sample liquid and is used to allow the liquid-phase fluid to elute the first sample liquid to form a test solution.

[0067] The detector is used to perform chromatographic analysis on the test solution flowing out of the chromatography column.

[0068] The liquid-phase fluid supply assembly includes a first driving device and the above-described energy storage device. The first driving device is used to drive the liquid-phase fluid to flow towards the switching valve and the chromatography column. The energy storage device is disposed between the first driving device and the switching valve.

[0069] The energy storage device, sample analysis system, and liquid chromatography analyzer provided by the present invention are configured by arranging an energy storage device and a locking and releasing device in the energy storage device. The locking and releasing device is set to release the potential energy storage and release assembly of the energy storage device in the release state to allow the energy storage device to store and release potential energy under the pressure of the liquid-phase fluid, and the locking and releasing device is set to lock the potential energy storage and release assembly in the locked state to prevent the energy storage device from releasing the stored potential energy, so that the energy storage device has the functions of storing and releasing potential energy. When this energy storage device is applied to a sample analysis system with a liquid chromatography analyzer, the potential energy stored by the energy storage device can be used to reduce the energy loss in the case of intermittent sample injection. The potential energy released by the energy storage device can be used to assist the liquid-phase fluid to quickly build pressure, thereby accelerating the speed of re-pressurization in the intermittent sample injection scenario. Specifically, applying the solution of the present invention to the intermittent sample injection scenario can avoid the problem that samples for intermittent sample injection need to wait for a long time to build pressure before entering the liquid chromatography analyzer for analysis, enabling each chromatographic analysis project to quickly generate a test report. Moreover, when the liquid chromatography analyzer is used in conjunction with other analyzers, it can prevent the transmission track from being blocked due to the long queue of samples in the liquid chromatography analyzer, which affects the sample transmission of other analyzers. This fully ensures the detection efficiency of samples in the online state. In addition, when the locking and releasing device locks the potential energy storage and release assembly, since the first driving device used to drive the liquid-phase fluid to flow in the liquid-phase fluid supply assembly is in a stopped state, it avoids the phenomenon of wasteful loss of liquid-phase fluid caused by the continuous operation of the first driving device when there is no sample detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0070] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can be obtained based on the structures shown in these drawings.

[0071] Figure 1 is a schematic structural diagram of a sample analysis system provided by Embodiment 1 of the present invention;

[0072] Figure 2 is a schematic composition diagram of a sample analysis system provided by Embodiment 1 of the present invention;

[0073] Figure 3 is a schematic liquid path diagram of a liquid chromatography analyzer provided by Embodiment 1 of the present invention when the switching valve is in the first communication state;

[0074] Figure 4 is a schematic liquid path diagram of a liquid chromatography analyzer provided by Embodiment 1 of the present invention when the switching valve is in the second communication state;

[0075] Figure 5 is a schematic cross-sectional view of the energy storage device and the locking and releasing device provided in the first embodiment of the present invention in the initial state;

[0076] Figure 6 is a schematic cross-sectional view of the energy storage device and the locking and releasing device provided in the first embodiment of the present invention in the state of performing a chromatographic analysis project;

[0077] Figure 7 is a schematic cross-sectional view of the locking and releasing device locking the energy storage device provided in the first embodiment of the present invention;

[0078] Figure 8 is a schematic external structure view of the energy storage device provided in the first embodiment of the present invention;

[0079] Figure 9 is a schematic cross-sectional view of the energy storage device provided in the first embodiment of the present invention;

[0080] Figure 10 is a three-dimensional schematic view of the liquid chromatography analyzer provided in the first embodiment of the present invention.

[0081] Explanation of the reference numerals in the drawings: 10, sample analysis system; 100, liquid chromatography analyzer; 110, sample supply assembly; 111, sampling component; 112, reaction vessel; 113, sample liquid delivery line; 120, liquid phase fluid supply assembly; 121, first driving device; 122, energy storage device; 1221, housing; 1221a, liquid inlet; 1221b, liquid outlet; 1222, potential energy storage and release assembly; 1222a, diaphragm; 1222b, elastic element; 1222c, guide rod; 1222d, clamping portion; 1223, liquid cavity; 123, locking and releasing device; 1231, power component; 1232, locking component; 1232a, locking portion; 1233, transmission component; 1234, detection component; 124, third driving device; 125, mixing component; 130, reversing valve; 140, sample liquid preparation channel; 150, chromatography column; 160, detector; 170, display screen assembly; 180, housing assembly; 190, waste liquid channel; 200, blood cell analyzer; 300, sample transmission device; 310, first transmission track; 320, second transmission track; 400, sample input device; 500, control component; 600, information acquisition device; 20, first fluid container; 30, second fluid container; 40, hemolytic agent container. Detailed implementation manners

[0082] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0083] In addition, the technical solutions between various embodiments can be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement them. When the combination of technical solutions results in contradictions or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the protection scope required by the present invention.

[0084] The solution provided in the embodiment of the present invention is preferably applicable to the scenario of intermittent sample injection (i.e., the samples are not injected continuously and concentratedly) of a liquid chromatography analyzer, so as to solve the problems of frequent pressure building and pressure relief in the intermittent sample injection scenario of the liquid chromatography analyzer, resulting in liquid phase fluid loss and low utilization efficiency, and the problem that the pressure building process takes a long time, resulting in a slow detection speed and inability to be used online with other analyzers. The liquid chromatography analyzer detects samples through liquid chromatography. Liquid chromatography refers to the separation by using the differences in the partition coefficients, adsorption capacities and other affinity abilities of various components in the sample in the liquid-solid two phases. Due to the differences in the properties and structures of each component, the magnitudes and strengths of the forces generated with the stationary phase are different. As the mobile phase moves, the mixture undergoes repeated distribution equilibria between the two phases, so that the retention times of various components by the stationary phase are different, and thus flow out of the stationary phase in a certain order.

[0085] The liquid chromatography analyzer provided in the embodiment of the present invention is preferably a glycosylated hemoglobin analyzer. The glycosylated hemoglobin analyzer provided in the embodiment of the present invention uses liquid chromatography to detect glycosylated hemoglobin. Since in specific applications, there are not many samples that need to be analyzed for glycosylated hemoglobin, there is generally a phenomenon of intermittent sample injection in glycosylated hemoglobin analyzers. Applying the solution of the embodiment of the present invention to the glycosylated hemoglobin analyzer is beneficial to the online use of the glycosylated hemoglobin analyzer with other analyzers, such as being online as a cascade system or a pipeline.

[0086] Embodiment 1:

[0087] As Figures 1 to 10As shown in the figure, the sample analysis system 10 provided in the first embodiment of the present invention includes a sample input device 400, a first analyzer, a second analyzer, a sample transmission device 300, and a control component 500. The sample analysis system 10 is a sample analysis cascade system or a sample analysis pipeline for connecting at least two analyzers online. The sample input device 400 is at least used for placing a sample container loaded with a sample to achieve sample loading. The sample container position is used for loading samples collected from patients. The first analyzer is used to aspirate a sample from the sample container and perform a first analysis item on at least a part of the aspirated sample. The second analyzer is used to aspirate a sample from the sample container and perform a second analysis item on at least a part of the aspirated sample. The sample transmission device 300 is used to transmit the sample container from the sample input device 400 to the first analyzer and / or the second analyzer. The control component 500 is used to control the sample transmission device 300 to transmit the sample container to the first analyzer and / or the second analyzer.

[0088] As an implementation manner, the sample input device 400 is at least used for placing a sample container loaded with a blood sample to achieve blood sample loading, that is, the sample analysis system 10 in this implementation manner is a cascade system or a pipeline for analyzing blood samples.

[0089] As an implementation manner, the first analyzer is a liquid chromatography analyzer 100, that is, the above-mentioned first analysis item is a chromatography analysis item. The liquid chromatography analyzer 100 is used to aspirate a blood sample from the sample container and perform chromatography analysis on at least a part of the aspirated blood sample. In this implementation manner, the liquid chromatography analyzer 100 can be used online with other analyzers without affecting the detection efficiency of other analyzers.

[0090] As an implementation manner, the second analyzer is a blood cell analyzer 200, that is, the above-mentioned second analysis item is a blood cell analysis item. The blood cell analyzer 200 is also called a blood routine analyzer or a blood cell analyzer, and the blood cell analysis item is also called a blood routine analysis item. The blood cell analyzer 200 is used to aspirate a blood sample from the sample container and perform blood cell analysis on at least a part of the aspirated blood sample. The demand for blood cell analysis is relatively large in specific applications. Connecting the liquid chromatography analyzer 100 and the blood cell analyzer 200 online is conducive to the chromatography analysis item and the blood cell analysis item sharing the blood sample in the same sample container, so as to obtain two test results, namely the liquid chromatography analysis result and the blood cell analysis result of the blood sample in one sample container, thereby reducing the amount of blood samples collected from patients and the consumption of sample containers.

[0091] As an implementation manner, the sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography analyzer 100, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the blood cell analyzer 200. The first transfer track 310 and the second transfer track 320 are integrally formed or connected to each other, that is, the first transfer track 310 and the second transfer track 320 can be the same transfer track or two spliced transfer tracks. The sample transfer device 300 enables the sample container of the sample input device 400 to be automatically conveyed to the liquid chromatography analyzer 100 or automatically transferred to the blood cell analyzer 200, without manual sorting and transferring of the sample container between the liquid chromatography analyzer 100 and the blood cell analyzer 200, which helps to reduce the workload of the operator and improve the detection efficiency of batch samples.

[0092] As an implementation manner, the sampling position of the liquid chromatography analyzer 100 can be inside the machine or on the first transfer track 310 outside the machine. When the sampling position of the liquid chromatography analyzer 100 is inside the machine, the liquid chromatography analyzer 100 has a first sampling channel inside. The sample container transferred by the first transfer track 310 to the side of the liquid chromatography analyzer 100 can be scheduled to the sampling position of the first sampling channel through the first sample scheduling component.

[0093] As an implementation manner, the sampling position of the blood cell analyzer 200 can be inside the machine or on the second transfer track 320 outside the machine. When the sampling position of the blood cell analyzer 200 is inside the machine, the blood cell analyzer 200 has a second sampling channel inside. The sample container transferred by the second transfer track 320 to the side of the blood cell analyzer 200 can be scheduled to the sampling position of the second sampling channel through the second sample scheduling component.

[0094] As an implementation manner, the sample analysis system 10 further includes an information acquisition device 600, and the information acquisition device 600 is used to acquire information characterizing the type of the test item of the blood sample in the sample container. The control component 500 is configured to: determine the type of the test item of the blood sample in the sample container according to the information characterizing the type of the test item of the blood sample in the sample container fed back by the information acquisition device 600; and control the sample transfer device 300 to transfer the sample container to the liquid chromatography analyzer 100 and / or the blood cell analyzer 200 for sampling according to the type of the test item of the blood sample in the sample container. The setting of the information acquisition device 600 enables the control component 500 to automatically determine which analyzer to transfer the sample container to for analysis according to the information fed back by the information acquisition device 600.

[0095] As an implementation manner, the liquid chromatography analyzer 100 includes a sample supply component 110, a liquid-phase fluid supply component 120, a switching valve 130, a sample solution preparation channel 140, a chromatography column 150, and a detector 160. The sample supply component 110, the liquid-phase fluid supply component 120, the sample solution preparation channel 140, and the chromatography column 150 are respectively connected to different interfaces of the switching valve 130 through liquid paths. The switching valve 130 is mainly used to switch the flow direction of the liquid in the liquid path. The sample supply component 110 is used to suck a blood sample from a sample container and supply a first sample solution made of at least part of the sucked blood sample to the sample solution preparation channel 140 through the switching valve 130. The liquid-phase fluid supply component 120 is used to drive the first sample solution in the sample solution preparation channel 140 to be transported to the chromatography column 150 through the liquid-phase fluid, and is used to drive the liquid-phase fluid to flow through the switching valve 130 and the chromatography column 150 in sequence. The chromatography column 150 is used to adsorb the first sample solution and to allow the liquid-phase fluid to elute the first sample solution to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatography column 150.

[0096] As an implementation manner, the switching valve 130 has a switchable first connection state and second connection state: in the first connection state, the switching valve 130 connects the sample supply component 110 and the sample solution preparation channel 140 and connects the liquid-phase fluid supply component 120 and the chromatography column 150. In the second connection state, the switching valve 130 connects the liquid-phase fluid supply component 120, the sample solution preparation channel 140, and the chromatography column 150. The chromatography column 150 is connected between the switching valve 130 and the detector 160. The switching valve 130 can be switched between the first connection state and the second connection state under the control of the control component 500. In the first connection state, the sample supply component 110 can drive the first sample solution to be transported to the sample solution preparation channel 140, and the liquid-phase fluid supply component 120 can drive the liquid-phase fluid to be transported to the chromatography column 150. In the second connection state, the liquid-phase fluid supply component 120 can drive the liquid-phase fluid to drive the first sample solution in the sample solution preparation channel 140 to be transported to the chromatography column 150. At this time, the sample supply component 110 cannot drive the first sample solution to be transported to the sample solution preparation channel 140.

[0097] As an implementation manner, the liquid-phase fluid supply assembly 120 includes a first driving device 121 and an energy storage device. The energy storage device includes an energy storage component 122 and a locking and releasing device 123. The first driving device 121 is configured to drive the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150. The energy storage component 122 is disposed between the first driving device 121 and the switching valve 130. The energy storage component 122 is used for storing potential energy and releasing potential energy. The locking and releasing device 123 is used for locking and releasing the energy storage component 122. The locking and releasing device 123 can be switched between a locked state and a released state. In a specific application, when the locking and releasing device 123 is in the released state, the energy storage component 122 can store potential energy under the pressure of the liquid-phase fluid; when the locking and releasing device 123 is in the locked state, the energy storage component 122 is locked, and the potential energy stored by the energy storage component 122 cannot be released; when the locking and releasing device 123 is switched from the locked state to the released state, the potential energy stored by the energy storage component 122 can be released. In this implementation scheme, by providing the energy storage component 122 and the locking and releasing device 123 in the liquid-phase fluid supply assembly 120, the locking and releasing device is set to release the potential energy of the energy storage component 122 in the released state to allow the energy storage component 122 to store and release potential energy under the pressure of the liquid-phase fluid, and the locking and releasing device is set to lock the potential energy storage and release assembly 1222 in the locked state to prevent the energy storage component 122 from releasing the stored potential energy, so that the liquid-phase fluid supply assembly 120 not only has the function of providing liquid-phase fluid with a certain pressure, but also has the functions of storing potential energy and releasing potential energy.

[0098] As an implementation manner, the energy storage component 122 includes a housing 1221 and a potential energy storage and release assembly 1222. The potential energy storage and release assembly 1222 is at least partially disposed in the housing 1221 and forms a liquid chamber 1223 for the liquid-phase fluid to flow through by partitioning in the housing 1221. The potential energy storage and release assembly 1222 can at least partially move relative to the housing 1221 to change the size of the liquid chamber 1223 and store potential energy or release the stored potential energy.

[0099] As an implementation manner, the locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, thereby preventing the potential energy storage and release component 1222 from moving relative to the housing 1221 and preventing the potential energy storage and release component 1222 from releasing the stored potential energy. In the released state, the potential energy storage and release component 1222 can move relative to the housing 1221 under the pressure of the liquid-phase fluid to store potential energy, and, when the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222, the potential energy storage and release component 1222 is released, thereby allowing the potential energy storage and release component 1222 to move relative to the housing 1221 and allowing the potential energy storage and release component 1222 to release the stored potential energy. In this implementation scheme, the locking and releasing device 123 locks the potential energy storage and release component 1222 by directly applying a force to the potential energy storage and release component 1222.

[0100] As an implementation manner, the control component 500 is further configured to: during the execution of a chromatographic analysis project, control the first driving device 121 to drive the liquid-phase fluid to flow so as to elute the first sample liquid adsorbed on the chromatography column 150, and control the locking and releasing device 123 to be in a released state to allow the potential energy storage and release component 1222 to move relative to the housing 1221 under the pressure action of the liquid-phase fluid to store potential energy; within a first preset duration after the execution of a chromatographic analysis project for a blood sample is completed, if no information indicating that there is another blood sample requiring a chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the released state to the locked state to prevent the potential energy storage and release component 1222 from moving relative to the housing 1221, thereby preventing the potential energy storage and release component 1222 from releasing the stored potential energy, and control the first driving device 121 to stop driving the liquid-phase fluid to flow; after the locking and releasing device 123 switches to the locked state, if information indicating that there is a blood sample requiring a chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the locked state to the released state, so that the potential energy storage and release component 1222 can move relative to the housing 1221 to release the stored potential energy to assist in driving the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150. In this implementation, the potential energy stored by the energy storage device 122 is utilized to reduce the energy loss in the case of intermittent sample injection; the potential energy released by the energy storage device 122 is utilized to assist the liquid-phase fluid in quickly building pressure, thereby accelerating the speed of re-building pressure in the case of intermittent sample injection, and further avoiding the problem that the blood sample in the case of intermittent sample injection needs to wait for a long time for pressure building before entering the liquid chromatography analyzer 100 for analysis, enabling each chromatographic analysis project to quickly generate a test report, and when the liquid chromatography analyzer 100 is used in conjunction with other analyzers, preventing the occurrence of the bad phenomenon that the transmission track is blocked due to the long queue of blood samples in the liquid chromatography analyzer 100, thus fully ensuring the detection efficiency of the samples in the on-line state. In addition, when the locking and releasing device 123 locks the potential energy storage and release component 1222, since the first driving device 121 for driving the liquid-phase fluid to flow in the liquid-phase fluid supply component 120 is in a stopped operating state, the bad phenomenon of waste of liquid-phase fluid caused by the continuous operation of the first driving device 121 when there is no blood sample for chromatographic analysis project detection is avoided.

[0101] As an implementation manner, the potential energy storage and release component 1222 stores and releases elastic potential energy. Specifically, the potential energy storage and release component 1222 converts a part of the pressure energy of the liquid-phase fluid into elastic potential energy by relying on the way of driving the elastic component to deform, stores it when needed, and releases it when necessary. Its structure is simple and the cost is low. The potential energy storage and release component 1222 adopts a component that stores and releases elastic potential energy, so that the potential energy storage and release component 1222 can also play a role in eliminating the pressure pulsation or flow pulsation of the liquid-phase fluid in the pipeline. Of course, in specific applications, the setting manner of the potential energy storage and release component 1222 is not limited to this. For example, as an alternative implementation manner, the potential energy stored and released by the potential energy storage and release component 1222 is gravitational potential energy, and it converts the pressure energy of the liquid-phase fluid into gravitational potential energy by lifting the mass block loaded on the sealing piston; or, as another alternative implementation manner, the potential energy stored and released by the potential energy storage and release component 1222 is gas internal energy, and the energy conversion is completed by compressing the gas. When using, first fill the energy storage device 122 with gas at a predetermined pressure. When the pressure of the liquid-phase fluid exceeds the pressure inside the energy storage device 122, the liquid-phase fluid compresses the gas and converts the pressure of the liquid-phase fluid into gas internal energy; when the pressure of the liquid-phase fluid is lower than the pressure inside the energy storage device 122, the liquid-phase fluid in the energy storage device 122 flows out of the energy storage device 122 under the action of the high-pressure gas to release energy.

[0102] As an implementation manner, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 in a non-liquid path locking manner to lock the potential energy storage and release component 1222, and the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222 in a non-liquid path conducting manner to release the potential energy storage and release component 1222. In this implementation manner, the locking and releasing device 123 is not connected to the energy storage device 122 through a liquid path, but locks and releases the potential energy storage and release component 1222 of the energy storage device 122 through a mechanical structure. In this way, the setting of the locking and releasing device 123 will not affect the original liquid path system of the liquid chromatography analyzer 100.

[0103] As an implementation manner, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 by abutting against the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, and the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222 by detaching from the potential energy storage and release component 1222 to release the potential energy storage and release component 1222. In this implementation, the locking and releasing device 123 locks and limits the potential energy storage and release component 1222 by directly contacting the potential energy storage and release component 1222, and the locking and releasing device 123 releases the limitation on the potential energy storage and release component 1222 by detaching from the potential energy storage and release component 1222. Of course, in specific applications, as an alternative implementation, the locking and releasing device 123 can also apply a force to the potential energy storage and release component 1222 by non-contact with the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, for example, by magnetic attraction.

[0104] As an implementation manner, the potential energy storage and release component 1222 has a clamping portion 1222d extending outside the housing 1221. The locking and releasing device 123 applies a force to the potential energy storage and release component 1222 by limiting the clamping portion 1222d to lock the potential energy storage and release component 1222; the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222 by releasing the clamping portion 1222d to release the potential energy storage and release component 1222. In this implementation, the locking and releasing device 123 locks the potential energy storage and release component 1222 by limiting the clamping portion 1222d of the potential energy storage and release component 1222 extending outside the housing 1221, without machining a structure in the housing 1221 that cooperates with the locking and releasing device 123, so as to simplify the structure of the energy storage device 122. Of course, in specific applications, as an alternative implementation, the locking and releasing device 123 can also be arranged to lock and limit the potential energy storage and release component 1222 by passing through the housing 1221.

[0105] As an implementation manner, the locking and releasing device 123 includes a power component 1231, a locking component 1232, and a transmission component 1233 that is transmission-connected between the power component 1231 and the locking component 1232. The power component 1231 is used to drive the transmission component 1233 to move, and the movement of the transmission component 1233 will drive the locking component 1232 to move, so that the locking component 1232 moves to the locking position or the unlocking position. In the locking position, the locking component 1232 abuts against the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222. In the unlocking position, the locking component 1232 detaches from the potential energy storage and release component 1222 to release the potential energy storage and release component 1222.

[0106] As an implementation manner, when the locking and releasing device 123 is in the locked state, the locking component 1232 is in the locking position to lock the potential energy storage and release component 1222.

[0107] As an implementation manner, the transmission component 1233 has a self-locking ability. When the locking and releasing device 123 is in the locked state, the power component 1231 is in a stopped operating state, and the locking component 1232 is in a locked position by the locking force generated by the self-locking of the transmission component 1233 to lock the potential energy storage and release component 1222. In this implementation, through the self-locking of the transmission component 1233, the locking component 1232 is kept in the state of locking the potential energy storage and release component 1222 without the need for the power component 1231 to provide power locking. The power component 1231 is only used to drive the transmission component 1233 to drive the locking component 1232 to move between the locked position and the unlocked position, thereby reducing the load requirement of the power component 1231, which is conducive to reducing the cost of the locking and releasing device 123.

[0108] As an implementation manner, the power component 1231 is a motor; when the locking and releasing device 123 is in the locked state, the motor is in a stopped operating state, and the locking component 1232 is in a locked position by the locking force generated by the self-locking of the transmission component 1233 to lock the potential energy storage and release component 1222; when the locking and releasing device 123 is in the released state, the motor is in a stopped operating state, and the locking component 1232 is in the unlocked position to release the potential energy storage and release component 1222; during the process of the locking and releasing device 123 switching from the locked state to the released state, the motor is in an operating state to drive the locking component 1232 to move from the locked position to the unlocked position through the transmission component 1233; during the process of the locking and releasing device 123 switching from the released state to the locked state, the motor is in an operating state to drive the locking component 1232 to move from the unlocked position to the locked position through the transmission component 1233.

[0109] As an implementation manner, the potential energy storage and release component 1222 has a clamping position portion 1222d extending outside the housing 1221, and the clamping position portion 1222d has a clamping end face facing the liquid chamber 1223; the locking component 1232 is formed with a locking portion 1232a, and the locking portion 1232a is used to move between the locked position and the unlocked position under the drive of the power component 1231 and the transmission component 1233.

[0110] As an implementation manner, controlling the locking and releasing device 123 to switch to the locked state to prevent the energy storage device 122 from releasing the stored potential energy includes: controlling the power component 1231 to start and operate to drive the transmission component 1233 to drive the locking portion 1232a to move from the unlocked position to the locked position so that the locking portion 1232a abuts against the clamping end face. After the locking portion 1232a moves to the locked position, controlling the power component 1231 to stop operating so that the locking portion 1232a is kept in the locked position under the action of the locking force generated by the self-locking of the transmission component 1233.

[0111] As an implementation manner, switching the above control lock-release device 123 from the locked state to the released state to enable the energy storage device 122 to release the stored potential energy includes: controlling the power component 1231 to start and operate to drive the transmission component 1233 to drive the locking portion 1232a to move from the locked position to the unlocked position, so that the locking portion 1232a disengages from the clamping end face, thereby enabling the potential energy storage and release assembly 1222 to release the stored potential energy and move towards the liquid chamber 1223 to drive the liquid-phase fluid in the liquid chamber 1223 to flow out of the liquid chamber 1223.

[0112] As an implementation manner, the lock-release device 123 further includes a detection component 1234, and the control component 500 is further configured to: during the process that the power component 1231 drives the transmission component 1233 to drive the locking portion 1232a to move from the unlocked position to the locked position, obtain the feedback information of the detection component 1234, and when it is determined according to the feedback information of the detection component 1234 that the locking portion 1232a moves to the locked position, control the power component 1231 to stop operating.

[0113] As an implementation manner, the detection component 1234 is a reflective photoelectric sensor or an opposed photoelectric sensor or a proximity switch.

[0114] As an implementation manner, the potential energy stored and released by the potential energy storage and release assembly 1222 is elastic potential energy; the potential energy storage and release assembly 1222 includes a diaphragm 1222a, an elastic element 1222b, and a guide rod 1222c. The diaphragm 1222a is arranged in the housing 1221 and cooperates with the inner wall of the housing 1221 to form a liquid chamber 1223. One end of the guide rod 1222c is connected to the diaphragm 1222a, and the other end of the guide rod 1222c extends outside the housing 1221 and is formed with a clamping portion 1222d. The elastic element 1222b is located in the housing 1221 and sleeved on the guide rod 1222c. The lock-release device 123 being in the locked state includes: the locking portion 1232a abuts against the clamping portion 1222d to lock the clamping portion 1222d, thereby enabling the elastic element 1222b to store elastic potential energy; the lock-release device 123 being in the released state includes: the locking portion 1232a disengages from the clamping portion 1222d to release the clamping portion 1222d, thereby allowing the elastic element 1222b to release elastic potential energy.

[0115] As an implementation manner, when the locking and releasing device 123 is in the releasing state, the guide rod 1222c can move away from the liquid cavity 1223 under the pressure of the liquid-phase fluid against the force of the elastic element 1222b, and can move towards the liquid cavity 1223 under the force of the elastic element 1222b; when the locking and releasing device 123 is in the locking state, the guide rod 1222c can move away from the liquid cavity 1223 under the pressure of the liquid-phase fluid against the force of the elastic element 1222b, but cannot move towards the liquid cavity 1223 under the force of the elastic element 1222b.

[0116] As an implementation manner, the first driving device 121 can adopt a plunger pump.

[0117] As an implementation manner, the energy storage device 122 can smooth the pulsed flow output by the first driving device 121 and reduce the flow fluctuation through the elastic element 1222b.

[0118] As an implementation manner, the diaphragm 1222a is a diaphragm made of an elastic material, with its periphery sealed and fixed, and a rod is embedded in the center, and the rod is connected to or integrally formed with the guide rod 1222c.

[0119] As an implementation manner, the stiffness of the elastic element 1222b is greater than or equal to 500 N / mm and less than or equal to 30000 N / mm.

[0120] As an implementation manner, the elastic element 1222b includes at least a pair of disc spring groups. The disc springs have large elasticity and can meet the requirement of providing a large driving force for the liquid-phase fluid.

[0121] As an implementation manner, the transmission component 1233 includes a lead screw transmission pair, and the lead angle of the lead screw transmission pair is less than the equivalent friction angle.

[0122] As an implementation manner, the transmission component 1233 includes a lead screw transmission pair, and the lead screw transmission pair is a trapezoidal lead screw transmission pair. The motor torque of this implementation scheme only needs to be able to drive the locking component 1232 to move under no-load, and does not need to overcome the force of the elastic element 1222b. Therefore, the torque output by the motor in this implementation scheme can be set much smaller than the torque required to pull the deformed elastic element 1222b.

[0123] As an implementation manner, the lead screw transmission pair includes a lead screw and a nut. The nut is connected to the lead screw and is also connected to the guide shaft. The function of the guide shaft is to convert the rotational motion of the nut into a linear motion. The locking component 1232 is connected to the nut of the lead screw pair. The lead screw transmission pair in this implementation scheme is a trapezoidal lead screw transmission pair with a self-locking function, which meets the self-locking condition that the lead angle is less than the equivalent friction angle. The output shaft of the motor is fixedly connected to the lead screw to provide power for the rotation of the lead screw.

[0124] As an implementation manner, the detection component 1234 is an optocoupler, which is fixed on the base. A photocoupler baffle is connected to the locking component 1232.

[0125] As an implementation manner, the working principle of the energy storage device 122 and the locking and releasing device 123 is as follows: when the high-pressure liquid-phase fluid flows into the energy storage device 122, the diaphragm 1222a deforms toward the side where the elastic element 1222b is located under the pressure of the liquid-phase fluid, and the load is transmitted to the elastic element 1222b by the guide rod 1222c, converting the pressure potential energy of the liquid-phase fluid into the elastic potential energy of the elastic element 1222b. At the same time, the guide rod 1222c moves away from the liquid cavity 1223. In this implementation, the locking portion 1232a holds the positioning portion 1222d of the extended guide rod 1222c, preventing it from rebounding under the action of the elastic element 1222b, so that the elastic element 1222b retains its elastic potential energy. In the initial position state of the locking and releasing device 123, the diaphragm 1222a of the energy storage device 122 is not deformed, and the elastic element 1222b in the energy storage device 122 is in the initial state (with pre-pressure or not stressed). When the energy storage device 122 works, the diaphragm 1222a deforms away from the liquid cavity 1223, driving the guide rod 1222c to displace toward the side where the elastic element 1222b is located, and fluctuating within a small range with the input of the pulse flow rate of the liquid-phase fluid. When the energy storage device 122 stops working, due to the damping effect of the system, its pressure slowly decreases. At this time, under the action of the elastic element 1222b, the guide rod 1222c gradually moves toward the liquid cavity 1223. At this time, the motor of the locking and releasing device 123 rotates, driving the locking component 1232 to move away from the liquid cavity 1223 until the locking portion 1232a contacts the positioning portion 1222d of the guide rod 1222c. At this time, the motor drives the locking component 1232 to move a certain distance away from the liquid cavity 1223 and stop. This distance should be greater than the maximum distance that the guide rod 1222c moves to the right. Since the torque of the motor is not enough to overcome the force of the elastic element 1222b, it will not pull the guide rod 1222c overly to the right. At this time, the motor may be blocked for a short time. Due to the self-locking effect of the lead screw transmission pair, the guide rod 1222c will not continue to move to the left under the action of the elastic element 1222b, but will continue to maintain this state. At this time, the liquid in the liquid cavity 1223 will only flow out in a small amount due to the absence of additional load, thus reducing the consumption of the liquid-phase fluid. The next time the pressure is built up, only a small amount of liquid-phase fluid is needed to fill the liquid cavity 1223, reducing the pressure build-up time. At the same time, after the liquid path system builds up pressure, the pressure causes the guide rod 1222c to move to the right again and disengage from the locking component 1232. At this time, the motor drives the locking component 1232 back to the initial position state for locking the guide rod 1222c next time.

[0126] As an implementation manner, if information that a blood sample needs to perform a chromatographic analysis item is obtained, the control locking and releasing device 123 is controlled to switch from the locked state to the released state, including: if information that a blood sample needs to perform a chromatographic analysis item is obtained, first control the first driving device 121 to start and operate, and then control the locking and releasing device 123 to switch from the locked state to the released state. In this implementation manner, before the locking and releasing device 123 switches from the locked state to the released state, first control the first driving device 121 to start and operate, so that the liquid phase fluid has a certain pressure, thereby avoiding the occurrence of a bad phenomenon that the locking and releasing device 123 switches from the locked state to the released state and completely releases the potential energy, resulting in the need for a large pressure to re-drive the potential energy storage and release component 1222 to expand.

[0127] As an implementation manner, the control component 500 is further configured to: during the process of performing the chromatographic analysis item, control the first driving device 121 to drive the liquid phase fluid to flow at a target pressure value or a pressure value within a target pressure range to elute the first sample liquid adsorbed on the chromatography column 150; before the first chromatographic analysis item after the liquid chromatography analyzer 100 is powered on, first control the first driving device 121 to start and keep running for a third preset duration, so that the pressure of the liquid phase fluid flowing to the chromatography column 150 reaches the target pressure value or the target pressure range. The third preset duration is the pressure build-up duration before the first chromatographic analysis item after the liquid chromatography analyzer 100 is powered on, that is, the duration for the pressure of the liquid phase fluid in the liquid path system to increase from zero to the target pressure value or the target pressure range.

[0128] As an implementation manner, the target pressure value is greater than or equal to 2 MPa and less than or equal to 10 MPa.

[0129] As an implementation manner, the target pressure value is greater than or equal to 4 MPa and less than or equal to 6 MPa.

[0130] As an implementation manner, first controlling the first driving device 121 to start and operate, and then controlling the locking and releasing device 123 to switch from the locked state to the released state includes: first controlling the first driving device 121 to start and keep operating for a second preset duration, so that the pressure of the liquid-phase fluid flowing to the chromatography column 150 is greater than zero and less than the target pressure value or less than the lower limit of the target pressure range, and then controlling the locking and releasing device 123 to switch from the locked state to the released state. The control component 500 is further configured to: after controlling the locking and releasing device 123 to switch from the locked state to the released state, first control the first driving device 121 to continue to keep operating for a fourth preset duration, so that the pressure of the liquid-phase fluid flowing to the chromatography column 150 substantially reaches the target pressure value or the target pressure range, and then control the switching valve 130 to switch to the second communication state, so that the liquid-phase fluid supply component 120 drives the first sample liquid in the sample liquid preparation channel 140 to be transported to the chromatography column 150 through the liquid-phase fluid; wherein, the sum of the second preset duration and the fourth preset duration is less than the third preset duration. The sum of the second preset duration and the fourth preset duration is the pressure build-up duration during the discontinuous sample injection process. In this implementation manner, the potential energy stored by the energy storage device 122 is used to assist the pressure build-up drive during the discontinuous sample injection process, shortening the pressure build-up duration during the discontinuous sample injection process.

[0131] Preferably, the sum of the second preset duration and the fourth preset duration is less than half of the third preset duration.

[0132] Preferably, the sum of the second preset duration and the fourth preset duration is less than or equal to one-tenth of the third preset duration.

[0133] As an implementation manner, the housing 1221 is formed with a liquid inlet 1221a for the liquid-phase fluid to flow into the liquid chamber 1223 and a liquid outlet 1221b for the liquid-phase fluid to flow out of the liquid chamber 1223; after controlling the locking and releasing device 123 to switch to the locked state and controlling the first driving device 121 to stop driving the liquid-phase fluid to flow, and before controlling the first driving device 121 to start and controlling the locking and releasing device 123 to switch from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is the first pressure value; after the first driving device 121 starts and keeps operating for the second preset duration and during the process of the locking and releasing device 123 switching from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is the second pressure value; after the locking and releasing device 123 switches from the locked state to the released state, the pressure value of the liquid-phase fluid at the liquid outlet 1221b is the third pressure value. Wherein, the second pressure value is greater than the first pressure value and greater than the third pressure value. In this implementation manner, during the process of re-building the pressure in the discontinuous sample injection, the pressure of the liquid-phase fluid first increases and then decreases under the auxiliary drive of the potential energy released by the energy storage device 122, which is beneficial to achieving the purpose of rapid pressure build-up.

[0134] As an implementation manner, the first pressure value is less than the target pressure value or less than the lower limit value of the target pressure range; the second pressure value is greater than the target pressure value or greater than the upper limit value of the target pressure range; the third pressure value is approximately equal to the target pressure value or falls within the target pressure range.

[0135] As an implementation manner, after controlling the lock-release device 123 to switch to the locked state and controlling the first driving device 121 to stop driving the liquid-phase fluid to flow, and before controlling the first driving device 121 to start and controlling the lock-release device 123 to switch from the locked state to the released state, the volume of the liquid chamber 1223 is the first volume; after the first driving device 121 starts and operates for a second preset duration and before the lock-release device 123 switches from the locked state to the released state, the volume of the liquid chamber 1223 is the second volume; after the lock-release device 123 switches from the locked state to the released state, the volume of the liquid chamber 1223 is the third volume; wherein, the second volume is greater than the first volume and greater than the third volume. In this implementation scheme, during the process of intermittent sample injection and re-pressurization, the volume of the liquid chamber 1223 first increases and then decreases, which is beneficial to achieving the purpose of rapid pressurization.

[0136] As an implementation manner, the first volume is less than or approximately equal to the volume of the liquid chamber 1223 during the execution of the chromatographic analysis item, the second volume is greater than the volume of the liquid chamber 1223 during the execution of the chromatographic analysis item, and the third volume is approximately equal to the volume of the liquid chamber 1223 during the execution of the chromatographic analysis item.

[0137] As an implementation manner, after controlling the lock-release device 123 to switch to the locked state and controlling the first driving device 121 to stop driving the liquid-phase fluid to flow, and before controlling the first driving device 121 to start running and controlling the lock-release device 123 to switch from the locked state to the released state, the potential energy stored in the energy storage device 122 is the first potential energy; after controlling the first driving device 121 to start and operate for a second preset duration and before controlling the lock-release device 123 to switch from the locked state to the released state, the potential energy stored in the energy storage device 122 is the second potential energy; after the lock-release device 123 switches from the locked state to the released state, the potential energy stored in the energy storage device 122 is the third potential energy; wherein, the second potential energy is greater than the first potential energy and greater than the third potential energy.

[0138] As an implementation manner, the first potential energy is less than or approximately equal to the potential energy stored in the energy storage device 122 during the execution of the chromatographic analysis item, the first potential energy is greater than the potential energy stored in the energy storage device 122 during the execution of the chromatographic analysis item, and the third potential energy is approximately equal to the potential energy stored in the energy storage device 122 during the execution of the chromatographic analysis item.

[0139] As an implementation manner, the energy storage device 122 has an inlet 1221a for the inflow of the liquid-phase fluid and an outlet 1221b for the outflow of the liquid-phase fluid; after the control lock-release device 123 is switched to the locked state and the control first driving device 121 stops driving the liquid-phase fluid to flow, and before the control first driving device 121 starts and the control lock-release device 123 is switched from the locked state to the released state, the pressure value of the liquid-phase fluid at the outlet 1221b is the first pressure value; the first pressure value is approximately zero. In this implementation manner, when the first driving device 121 stops driving the liquid-phase fluid to flow and the energy storage device 122 is in the locked state, the pressure value of the liquid-phase fluid is approximately zero, which is beneficial to reducing the loss of the liquid path components caused by maintaining a high pressure in the liquid path for a long time.

[0140] As an implementation manner, within the first preset duration after completing the chromatographic analysis project of a blood sample, if no situation where there is another blood sample that needs to execute the chromatographic analysis project is obtained, controlling the lock-release device 123 to switch to the locked state and controlling the first driving device 121 to stop driving the liquid-phase fluid to flow includes: within the first preset duration after completing the chromatographic analysis project of a blood sample, if no information that there is another blood sample that needs to execute the chromatographic analysis project is obtained, first controlling the lock-release device 123 to switch to the locked state, and then controlling the first driving device 121 to stop driving the liquid-phase fluid to flow. In this implementation manner, when it is necessary to lock the energy storage device 122 to store potential energy, first controlling the lock-release device 123 to switch to the locked state and then controlling the first driving device 121 to stop operating. In this way, it is beneficial to prevent the energy storage device 122 from releasing potential energy through the pressure of the liquid-phase fluid when the lock-release device 123 is switched to the locked state, thereby better storing the potential energy of the energy storage device 122. Of course, in specific applications, the control sequence of the lock-release device 123 and the first driving device 121 is not limited to this. For example, as an alternative implementation manner, within the first preset duration after completing the chromatographic analysis project of a blood sample, if no information that there is another blood sample that needs to execute the chromatographic analysis project is obtained, controlling the lock-release device 123 to switch to the locked state and simultaneously controlling the first driving device 121 to stop driving the liquid-phase fluid to flow; or, as another alternative implementation manner, within the first preset duration after completing the chromatographic analysis project of a blood sample, if no information that there is another blood sample that needs to execute the chromatographic analysis project is obtained, first controlling the first driving device 121 to stop driving the liquid-phase fluid to flow, and then controlling the lock-release device 123 to switch to the locked state.

[0141] As an implementation manner, the control component 500 is further configured to: control the sample supply component 110 to complete the following sample liquid preparation actions within a fifth preset duration: suck a blood sample from a sample container and distribute it to the reaction container 112, and transport the first sample liquid made of at least the blood sample and a hemolytic agent in the reaction container 112 to the sample preparation channel through the switching valve 130; when the locking and releasing device 123 is in the locked state, if information that a blood sample needs to perform a chromatographic analysis item is obtained, control the liquid-phase fluid supply component 120 to complete the following pressure building actions within a sixth preset duration: control the first driving device 121 to start and operate, and control the locking and releasing device 123 to switch from the locked state to the released state, so that the pressure of the liquid-phase fluid supply component 120 driving the liquid-phase fluid to flow to the chromatography column 150 reaches a target pressure value or a target pressure range within the sixth preset duration; during the process of performing the chromatographic analysis item, control the first driving device 121 to drive the liquid-phase fluid to flow at a target pressure value or a pressure value within the target pressure range to elute the first sample liquid adsorbed on the chromatography column 150; wherein, the sixth preset duration is less than the fifth preset duration. The sixth preset duration is equal to the sum of the second preset duration and the fourth preset duration. In this implementation scheme, in an intermittent scenario, the duration of re-building pressure is less than the duration of preparing the sample liquid, which is beneficial for synchronizing the re-building of pressure and the preparation of the sample liquid.

[0142] As an implementation manner, the control component 500 is further configured to: when the locking and releasing device 123 is in the locked state and the switching valve 130 is in the first communication state, if information that a blood sample needs to perform a chromatographic analysis item is obtained, control the sample supply component 110 to perform the following sample liquid preparation actions: suck a blood sample from a sample container and distribute it to the reaction container 112, and transport the first sample liquid made of at least the blood sample and a hemolytic agent in the reaction container 112 to the sample preparation channel through the switching valve 130; during the process of the sample supply component 110 performing the sample liquid preparation actions, control the first driving device 121 to start and operate, control the locking and releasing device 123 to switch from the locked state to the released state, and control the switching valve 130 to remain in the first communication state; after the sample supply component 110 completes the sample liquid preparation actions, control the switching valve 130 to switch from the first communication state to the second communication state, so that the liquid-phase fluid supply component 120 drives the first sample liquid in the sample preparation channel 140 to be transported to the chromatography column 150 through the liquid-phase fluid. In this implementation scheme, when a blood sample that needs to perform a chromatographic analysis item is transmitted to the liquid chromatography analyzer 100, the sample liquid preparation actions can be directly performed without waiting, achieving the effect of immediate measurement of the blood sample when it arrives at the liquid chromatography analyzer 100, and effectively avoiding the occurrence of the bad phenomenon that the sample containers queue up on the transmission track and cause the transmission track to be blocked.

[0143] As an implementation manner, the control component 500 is further configured to: in the case that the locking and releasing device 123 continuously remains in the locked state for a seventh preset duration, if the information that there is a blood sample for which a chromatographic analysis item needs to be performed is not obtained, control the locking and releasing device 123 to switch from the locked state to the released state, so that the energy storage device 122 releases the stored potential energy; the seventh preset duration is greater than the duration required to complete one chromatographic analysis item and greater than the first preset duration. In this implementation scheme, by restricting the duration of the locking and releasing device 123 continuously locking the energy storage device 122, it is beneficial to avoid the occurrence of the adverse phenomenon that the potential energy storage and release component 1222 is deformed for a long time and affects its service life.

[0144] As an implementation manner, the seventh preset duration is greater than or equal to the duration required to complete 10 chromatographic analysis items.

[0145] As an implementation manner, the seventh preset duration is greater than or equal to 5 minutes and less than or equal to 2 hours.

[0146] As an implementation manner, the liquid chromatography analyzer 100 further includes a waste liquid channel 190. In the first communication state, the switching valve 130 communicates with the sample supply component 110, the sample liquid preparation channel 140 and the waste liquid channel 190, and communicates with the liquid phase fluid supply component 120 and the chromatography column 150. In the second communication state, the switching valve 130 communicates with the liquid phase fluid supply component 120, the sample liquid preparation channel 140 and the chromatography column 150, and communicates with the sample supply component 110 and the waste liquid channel 190.

[0147] As an implementation manner, the liquid phase fluid supply component 120 further includes a third driving device 124. The above-mentioned first driving device 121 is used to drive the liquid phase fluid to flow towards the switching valve 130 and the chromatography column 150, including: the first driving device 121 sucks the first fluid from the first fluid container 20 and discharges it to the switching valve 130 and the chromatography column 150. The third driving device 124 is used to suck the second fluid from the second fluid container 30 and discharge it to the switching valve 130 and the chromatography column 150. During the process of the liquid phase fluid supply component 120 driving the first sample liquid in the sample liquid preparation channel 140 to be transported to the chromatography column 150, control the first driving device 121 to be in an operating state and control the third driving device 124 to be in a stopped operating state. The control component 500 is further configured to: during the elution process of a first sample liquid, respectively control the first driving device 121 and the second driving device 126 to operate, and regulate the working parameters of the first driving device 121 and the second driving device 126, so that the liquid phase fluid supply component 120 supplies liquid phase fluids containing at least two second fluids with different concentrations to the chromatography column 150 at different time periods; wherein, the ionic strength of the second fluid is greater than the ionic strength of the first fluid. In this implementation scheme, liquid phase fluids with different concentrations can be configured online, and the effect of gradient elution can be achieved.

[0148] As an implementation manner, the liquid-phase fluid supply assembly 120 further includes a housing assembly 180 and a mixing component 125. The mixing component 125 is provided with a first input port, a second input port, and an output port. The energy storage device 122 is connected between the first input port and the first driving device 121 through a liquid path. The third driving device 124 is connected to the second input port, and the reversing valve 130 is connected to the output port. The housing assembly 180 forms a first fluid chamber and a second fluid chamber. The first fluid chamber is used to accommodate the first fluid container 20, and the second fluid chamber is used to accommodate the second fluid container 30. The first driving device 121 is used to suck the first fluid from the first fluid container 20 and push it to the reversing valve 130. The third driving device 124 is used to suck the second fluid from the second fluid container 30 and push it to the reversing valve 130. In this implementation manner, by adjusting the different mixing ratios of the first fluid and the second fluid, an eluent containing the second fluid with different concentrations can be prepared, realizing the on-line preparation of eluents with different concentrations, meeting the requirements of different eluent concentrations, and facilitating the reduction of the amount of materials and material costs.

[0149] As an implementation manner, the first fluid may specifically be liquid A, and the second fluid may specifically be liquid B.

[0150] Of course, in specific applications, the liquid-phase fluid supply component 120 is not limited to the above-described gradient elution scheme. For example, as an alternative implementation, the liquid-phase fluid supply component 120 can also adopt an isocratic elution scheme. In this alternative implementation, the liquid-phase fluid supply component 120 further includes a switching member, and the input end of the first driving device 121 is switchably connected to a third fluid container loaded with a third fluid and a fourth fluid container loaded with a fourth fluid through the switching member. The above-mentioned first driving device 121 is used to drive the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150, including: in a state where the switching member conducts the first driving device 121 and the third fluid container, the first driving device 121 sucks the third fluid from the third fluid container and discharges it to the switching valve 130 and the chromatography column 150; in a state where the switching member conducts the first driving device 121 and the fourth fluid container, the first driving device 121 sucks the fourth fluid from the fourth fluid container and discharges it to the switching valve 130 and the chromatography column 150. The third fluid and the fourth fluid are two liquid-phase fluids containing second fluids with different concentrations. During the process of the liquid-phase fluid supply component 120 driving the first sample liquid in the sample liquid preparation channel 140 to the chromatography column 150, the switching member conducts the state of the first driving device 121 and the third fluid container, and controls the first driving device 121 to be in a starting and running state. The control component 500 is further configured to: during the elution of a first sample liquid, in the first elution stage, control the switching member to conduct the first driving device 121 and the third fluid container, and control the first driving device 121 to suck the third fluid from the third fluid container and discharge it to the switching valve 130 and the chromatography column 150; in the second elution stage, control the switching member to conduct the first driving device 121 and the fourth fluid container, and control the first driving device 121 to suck the fourth fluid from the fourth fluid container and discharge it to the switching valve 130 and the chromatography column 150, so that the liquid-phase fluid supply component 120 supplies at least two liquid-phase fluids containing second fluids with different concentrations to the chromatography column 150 at different times.

[0151] As an implementation manner, the sample supply component 110 includes a sampling component 111, a reaction container 112, and a sample liquid delivery path 113. The sampling component 111 is used to suck a sample from a sample container and distribute it to the reaction container 112. The sample liquid delivery path 113 is used to suck a lysing agent from a lysing agent container 40 and distribute it to the reaction container 112, and to deliver at least a first sample liquid made of a sample and a lysing agent in the reaction container 112 to the sample liquid preparation channel 140 through the switching valve 130. A suction and discharge power component 1231 is provided in the sample liquid delivery path 113. In this implementation, the lysing agent is distributed to the reaction container 112 by the sample liquid delivery path 113, so that the sample liquid delivery path 113 can be reused, and thus there is no need to provide an additional pipetting needle to distribute the lysing agent.

[0152] As an implementation manner, the sampling component 111 includes a sample needle and a motion driving component for driving the motion of the sample needle.

[0153] As an implementation manner, the liquid chromatography analyzer 100 further includes a display screen assembly 170, and the display screen assembly 170 is disposed on one side of the housing assembly 180 for an operator to view the chromatographic analysis information of the blood sample.

[0154] As an implementation manner, the working process of the liquid chromatography analyzer 100 includes: the sample supply component 110 sucks a sample from the sample container and distributes it to the reaction container 112, distributes a hemolytic agent to the reaction container 112, and the sample supply component 110 pushes the first sample liquid made of the sample and the hemolytic agent in the reaction container 112 to the sample liquid preparation channel 140. The liquid phase fluid supply component 120 drives the sample liquid in the sample liquid preparation channel 140 through the liquid phase fluid and pushes it to the chromatography column 150. The liquid phase fluid supply component 120 pushes the liquid phase fluid to the chromatography column 150 to elute the sample liquid adsorbed on the chromatography column 150, and the detector 160 performs chromatographic analysis on the test liquid eluted from the chromatography column 150.

[0155] As an implementation manner, the liquid chromatography analyzer 100 is a glycated hemoglobin analyzer.

[0156] As an implementation manner, the blood cell analyzer 200 is at least used for detecting the white blood cell differential count of a blood sample.

[0157] As an implementation manner, the blood cell analyzer 200 is further used for performing at least one of the following detections on the blood sample: reticulocyte count detection, hemoglobin detection, red blood cell detection, platelet detection.

[0158] As an implementation manner, the blood cell analyzer 200 performs white blood cell differential count detection and reticulocyte count detection on the sample liquid flowing through the detection area of the flow cell under the entrainment of the sheath fluid through the optical detection component.

[0159] As an implementation manner, the blood cell analyzer 200 performs red blood cell detection and platelet detection on the sample liquid through the impedance detection component.

[0160] This embodiment also provides a liquid chromatography analyzer 100, which includes a sample supply component 110, a liquid-phase fluid supply component 120, a switching valve 130, a sample liquid preparation channel 140, a chromatography column 150, and a detector 160. The chromatography column 150 is connected between the switching valve 130 and the detector 160. The switching valve 130 has a switchable first communication state and a second communication state: in the first communication state, the switching valve 130 connects the sample supply component 110 and the sample liquid preparation channel 140, and connects the liquid-phase fluid supply component 120 and the chromatography column 150; in the second communication state, the switching valve 130 connects the liquid-phase fluid supply component 120, the sample liquid preparation channel 140, and the chromatography column 150. The sample supply component 110 is used to suck a blood sample from a sample container and supply a first sample liquid made of at least a part of the sucked blood sample to the sample liquid preparation channel 140 through the switching valve 130. The liquid-phase fluid supply component 120 is used to drive the first sample liquid in the sample liquid preparation channel 140 to be transported to the chromatography column 150 by the liquid-phase fluid, and is used to drive the liquid-phase fluid to flow through the switching valve 130 and the chromatography column 150 in sequence. The chromatography column 150 is used to adsorb the first sample liquid and to allow the liquid-phase fluid to elute the first sample liquid to form a test liquid. The detector 160 is used to perform chromatographic analysis on the test liquid flowing out of the chromatography column 150. The liquid-phase fluid supply component 120 includes a first driving device 121, an energy storage device 122, and a locking and releasing device 123. The first driving device 121 is used to drive the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150. The energy storage device 122 is arranged between the first driving device 121 and the switching valve 130. The energy storage device 122 includes a housing 1221 and a potential energy storage and release component 1222. The potential energy storage and release component 1222 is at least partially arranged in the housing 1221 and forms a liquid chamber 1223 for the liquid-phase fluid to flow through in the housing 1221. At least a part of the potential energy storage and release component 1222 can move relative to the housing 1221 to change the size of the liquid chamber 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, thereby preventing the potential energy storage and release component 1222 from moving relative to the housing 1221 and preventing the potential energy storage and release component 1222 from releasing the stored potential energy; in the released state, the potential energy storage and release component 1222 can move relative to the housing 1221 under the pressure of the liquid-phase fluid to store potential energy, and, when the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222, the potential energy storage and release component 1222 is released, thereby allowing the potential energy storage and release component 1222 to move relative to the housing 1221 and allowing the potential energy storage and release component 1222 to release the stored potential energy.The control component 500 is further configured to: during the process of performing a chromatographic analysis project, control the first driving device 121 to drive the liquid-phase fluid to flow to elute the first sample liquid adsorbed on the chromatography column 150, and control the locking and releasing device 123 to be in the releasing state to allow the potential energy storage and release component 1222 to move relative to the housing 1221 under the pressure action of the liquid-phase fluid to store potential energy; within a first preset time period after completing the chromatographic analysis project of a blood sample, if no information about other blood samples that need to perform the chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the releasing state to the locking state to prevent the potential energy storage and release component 1222 from moving relative to the housing 1221, thereby preventing the potential energy storage and release component 1222 from releasing the stored potential energy, and control the first driving device 121 to stop driving the liquid-phase fluid to flow; after the locking and releasing device 123 switches to the locking state, if information about a blood sample that needs to perform the chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the locking state to the releasing state, so that the potential energy storage and release component 1222 can move relative to the housing 1221 to release the stored potential energy to assist in driving the liquid-phase fluid to flow to the switching valve 130 and the chromatography column 150. The working principle and other parts of the liquid chromatography analyzer 100 can refer to the introduction of the liquid chromatography analyzer 100 in the above sample analysis system 10, which will not be elaborated here.

[0161] This embodiment further provides an energy storage device, which includes an energy storage component 122 and a locking and releasing device 123. The energy storage component 122 includes a housing 1221 and a potential energy storage and release component 1222. At least part of the potential energy storage and release component 1222 is disposed in the housing 1221 and forms a liquid cavity 1223 for the liquid-phase fluid to flow through in the housing 1221. At least part of the potential energy storage and release component 1222 can move relative to the housing 1221 to change the size of the liquid cavity 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 can switch between a locking state and a releasing state: in the locking state, the locking and releasing device 123 applies a force to the potential energy storage and release component 1222 to lock the potential energy storage and release component 1222, thereby preventing the potential energy storage and release component 1222 from moving relative to the housing 1221 to prevent the potential energy storage and release component 1222 from releasing the stored potential energy; in the releasing state, the potential energy storage and release component 1222 can move relative to the housing 1221 under the pressure action of the liquid-phase fluid to store potential energy, and when the locking and releasing device 123 removes the force applied to the potential energy storage and release component 1222, the potential energy storage and release component 1222 is released, thereby allowing the potential energy storage and release component 1222 to move relative to the housing 1221 to allow the potential energy storage and release component 1222 to release the stored potential energy. The working principle and other parts of the energy storage device can refer to the introduction of the energy storage device in the above sample analysis system 10, which will not be elaborated here.

[0162] This embodiment also provides a control method for a liquid chromatography analyzer 100. The control method includes the following steps: within a first preset time period after completing a chromatographic analysis project of a blood sample, if no information about other blood samples that need to perform chromatographic analysis projects is obtained, control the locking and releasing device 123 to switch from the released state to the locked state to prevent the potential energy storage and release component 1222 from releasing the stored potential energy, and control the first driving device 121 to stop driving the liquid phase fluid to flow; after the locking and releasing device 123 switches to the locked state, if information about a blood sample that needs to perform a chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the locked state to the released state, so that the potential energy storage and release component 1222 releases the stored potential energy to assist in driving the liquid phase fluid to flow towards the chromatography column 150.

[0163] As an implementation manner, the above control method further includes: before the first chromatographic analysis project after the liquid chromatography analyzer 100 is powered on, first control the first driving device 121 to start and run for a third preset time period to make the pressure of the liquid phase fluid flowing towards the chromatography column 150 reach the target pressure value or the target pressure range; during the process of performing the chromatographic analysis project, control the first driving device 121 to drive the liquid phase fluid to flow at the target pressure value or within the pressure value within the target pressure range to elute the first sample solution adsorbed on the chromatography column 150.

[0164] As an implementation manner, in the above control method, if information about a blood sample that needs to perform a chromatographic analysis project is obtained, then control the locking and releasing device 123 to switch from the locked state to the released state, including: first control the first driving device 121 to start and run for a second preset time period to make the pressure of the liquid phase fluid flowing towards the chromatography column 150 greater than zero and less than the target pressure value or less than the lower limit value of the target pressure range, and then control the locking and releasing device 123 to switch from the locked state to the released state.

[0165] As an implementation manner, the above control method further includes: after controlling the locking and releasing device 123 to switch from the locked state to the released state, first control the first driving device 121 to continue running for a fourth preset time period to make the pressure of the liquid phase fluid flowing towards the chromatography column 150 approximately reach the target pressure value or the target pressure range, and then control the switching valve 130 to switch to the state of connecting the liquid phase fluid supply component 120, the sample solution preparation channel 140, and the chromatography column 150, so that the liquid phase fluid supply component 120 drives the first sample solution in the sample solution preparation channel 140 to be transported to the chromatography column 150 through the liquid phase fluid; wherein, the sum of the second preset time period and the fourth preset time period is less than the third preset time period.

[0166] The specific principle and implementation manner of the control method provided in this embodiment are similar to those described in the above sample analysis system 10, and will not be elaborated here.

[0167] This embodiment also provides a computer-readable storage medium. When the computer program stored in the computer-readable storage medium is executed by a processor (such as the above control component 500), the processor implements the steps of the control method of the above liquid chromatography analyzer 100. Among them, the computer-readable storage medium can be the internal storage unit of the above sample analysis system 10, such as the hard disk or memory of the sample analysis system 10; or, the computer-readable storage medium can also be an external storage device of the sample analysis system 10, such as a plug-in hard disk equipped on the sample analysis system 10, a Smart Media Card (SMC), a Secure Digital (SD) card, a Flash Card, etc.

[0168] In this embodiment, when the liquid chromatography analyzer 100 stops measuring, the elastic potential energy in the energy storage device 122 is stored through an electromechanical structure (the structure composed of a motor, a transmission component 1233, and a locking component 1232). The pressure of the liquid path system instantaneously drops to zero pressure or close to zero pressure, the liquid-phase fluid stops flowing, rapid pressure relief is achieved, and the liquid-phase fluid is stored in the energy storage device 122 and / or the pipeline. When starting the measurement next time, the electromechanical structure quickly releases the elastic potential energy in the energy storage device 122, the elastic potential energy quickly restores deformation, and squeezes the liquid-phase fluid to flow quickly, thereby achieving rapid pressure build-up and reducing the consumption of the liquid-phase fluid during the pressure build-up process. Since the liquid-phase fluid is also stored in the energy storage device 122 during the potential energy latching process, the consumption of the liquid-phase fluid is further reduced.

[0169] This embodiment has the following remarkable beneficial effects: (1) Through potential energy storage and release, the effects of rapid pressure build-up and saving liquid-phase fluid are achieved; (2) The liquid chromatography analyzer 100 can achieve the effect of immediate measurement when arriving in a cascade system and a production line; (3) The locking of the energy storage device 122 is provided by the self-locking of the lead screw transmission pair. The torque of the motor only needs to be able to drive the locking component 1232 to move under no-load, and does not need to overcome the force of the elastic element 1222b. Therefore, the torque output by the motor can be set to be much smaller than the torque required to pull the deformed elastic element 1222b, with a simple structure and low cost.

[0170] Embodiment 2:

[0171] The energy storage device, sample analysis system 10, liquid chromatography analyzer 100, and control method of the liquid chromatography analyzer 100 provided in this embodiment are mainly different from those in the first embodiment in that the locking manner of the locking and releasing device 123 on the potential energy storage and release component 1222 can be different, specifically manifested as follows: In the first embodiment, the locking and releasing device 123 focuses on locking the potential energy storage and release component 1222 by applying a force; while in this embodiment, the locking and releasing device 123 focuses on locking the potential energy storage and release component 1222 by abutting.

[0172] Specifically, the sample analysis system 10 provided in this embodiment includes a sample input device 400, a liquid chromatography analyzer 100, a blood cell analyzer 200, a sample transfer device 300, an information acquisition device 600, and a control component 500. The sample input device 400 is at least used for placing a sample container loaded with a blood sample to achieve the sampling of the blood sample. The liquid chromatography analyzer 100 is used to aspirate the blood sample from the sample container and perform chromatographic analysis on at least part of the aspirated blood sample; the blood cell analyzer 200 is used to aspirate the blood sample from the sample container and perform blood cell analysis on at least part of the aspirated blood sample. The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography analyzer 100, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the blood cell analyzer 200. The first transfer track 310 and the second transfer track 320 are integrally formed or connected to each other. The information acquisition device 600 is used to acquire information characterizing the type of test item of the blood sample in the sample container. The control component 500 is configured to: determine the type of test item of the sample in the sample container according to the information fed back by the information acquisition device 600 characterizing the type of test item of the sample in the sample container; and control the sample transfer device 300 to transfer the sample container to the liquid chromatography analyzer 100 and / or the blood cell analyzer 200 for sampling according to the type of test item of the sample in the sample container. Among them, the liquid chromatography analyzer 100 includes a sample supply component 110, a liquid phase fluid supply component 120, a switching valve 130, a sample liquid preparation channel 140, a chromatography column 150, and a detector 160. The switching valve 130 has a switchable first connection state and a second connection state: in the first connection state, the switching valve 130 connects the sample supply component 110 and the sample liquid preparation channel 140 and connects the liquid phase fluid supply component 120 and the chromatography column 150; in the second connection state, the switching valve 130 connects the liquid phase fluid supply component 120, the sample liquid preparation channel 140, and the chromatography column 150. The chromatography column 150 is connected between the switching valve 130 and the detector 160. The sample supply component 110 is used to aspirate the blood sample from the sample container and supply a first sample liquid made of at least part of the aspirated blood sample to the sample liquid preparation channel 140 through the switching valve 130. The liquid phase fluid supply component 120 is used to drive the first sample liquid in the sample liquid preparation channel 140 to be transported to the chromatography column 150 by the liquid phase fluid, and is used to drive the liquid phase fluid to flow through the switching valve 130 and the chromatography column 150 in sequence. The chromatography column 150 is used to adsorb the first sample liquid and is used to allow the liquid phase fluid to elute the first sample liquid to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatography column 150.The liquid-phase fluid supply assembly 120 includes a first driving device 121 and an energy storage device. The energy storage device includes an energy storage component 122 and a locking and releasing device 123. The first driving device 121 is configured to drive the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150. The energy storage component 122 is disposed between the first driving device 121 and the switching valve 130. The energy storage component 122 includes a housing 1221 and a potential energy storage and release assembly 1222. The potential energy storage and release assembly 1222 is at least partially disposed within the housing 1221 and forms a liquid chamber 1223 for the liquid-phase fluid to flow through within the housing 1221. At least a part of the potential energy storage and release assembly 1222 is capable of moving relative to the housing 1221 to change the size of the liquid chamber 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 is capable of switching between a locked state and a released state. The control assembly 500 is further configured to: during the process of performing a chromatographic analysis project, control the first driving device 121 to drive the liquid-phase fluid to flow to elute the first sample solution adsorbed on the chromatography column 150, and control the locking and releasing device 123 to be in the released state to allow the potential energy storage and release assembly 1222 to move relative to the housing 1221 under the pressure action of the liquid-phase fluid to store potential energy; within a first preset time period after completing the chromatographic analysis project of a blood sample, if no information about other blood samples that need to perform the chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the released state to the locked state to prevent the potential energy storage and release assembly 1222 from moving relative to the housing 1221, thereby preventing it from releasing the stored potential energy, and control the first driving device 121 to stop driving the liquid-phase fluid to flow; after the locking and releasing device 123 switches to the locked state, if information about a blood sample that needs to perform the chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the locked state to the released state, so that the potential energy storage and release assembly 1222 can move relative to the housing 1221 to release the stored potential energy to assist in driving the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150.

[0173] As an implementation manner, in this embodiment, in the locked state, the locking and releasing device 123 abuts against the potential energy storage and release assembly 1222 to lock the potential energy storage and release assembly 1222, thereby preventing it from moving relative to the housing 1221 and preventing the potential energy storage and release assembly 1222 from releasing the stored potential energy; in the released state, the potential energy storage and release assembly can move relative to the housing 1221 under the pressure action of the liquid-phase fluid to store potential energy, and when the locking and releasing device 123 disengages from the potential energy storage and release assembly 1222, the potential energy storage and release assembly 1222 is released, thereby allowing the potential energy storage and release assembly to move relative to the housing 1221 to allow the potential energy storage and release assembly 1222 to release the stored potential energy.

[0174] As an embodiment, the potential energy storage and release component 1222 has a locking portion 1222d extending outside the shell 1221, and the locking and releasing device 123 locks the potential energy storage and release component 1222 by abutting and limiting the locking portion 1222d. The locking and releasing device 123 releases the potential energy storage and release component 1222 by disengaging to release the locking portion 1222d.

[0175] As an embodiment, the locking and releasing device 123 includes a power component 1231, a locking component 1232 and a transmission component 1233 which is transmission-connected between the power component 1231 and the locking component 1232. The transmission component 1233 has a self-locking capability. When the locking and releasing device 123 is in a locked state, the power component 1231 is in a stopped state, and the locking component 1232 is in a locked position by a locking force generated by the self-locking of the transmission component 1233 to abut against the locking potential energy storage and release component 1222.

[0176] As an embodiment, the control component 500 is further configured to: control the sample supply component 110 to perform the following sample liquid preparation actions within a fifth preset time: draw a blood sample from the sample container and distribute it to the reaction container 112, and transport the first sample liquid made of at least the blood sample and the hemolytic agent in the reaction container 112 to the sample preparation channel through the reversing valve 130; when the lock and release device 123 is in a locked state, if information is obtained that a blood sample needs to perform a chromatographic analysis project, then control the liquid phase fluid supply component 120 to perform within a sixth preset time. The pressure building action is as follows: controlling the first driving device 121 to start and run, controlling the lock-release device 123 to switch from a locked state to a released state, so that the pressure of the liquid-phase fluid supply component 120 driving the liquid-phase fluid to flow to the chromatography column 150 reaches a target pressure value or a target pressure range within a fifth preset time length; in the process of executing the chromatographic analysis project, controlling the first driving device 121 to drive the liquid-phase fluid to flow at a target pressure value or a pressure value within the target pressure range to elute the first sample liquid adsorbed on the chromatography column 150; the sixth preset time length is less than the fifth preset time length.

[0177] In addition to the above, other parts of the energy storage device, the sample analysis system 10, the liquid chromatograph 100 and the control method of the liquid chromatograph 100 provided in this embodiment can refer to the first embodiment and will not be described in detail here.

[0178] Embodiment three:

[0179] The energy storage device, sample analysis system 10, liquid chromatography analyzer 100, and control method of the liquid chromatography analyzer 100 provided in this embodiment are mainly different from those in the first embodiment in that the locking manner of the lock and release device 123 for the potential energy storage and release component 1222 can be different, specifically reflected in: in the first embodiment, the lock and release device 123 focuses on locking the potential energy storage and release component 1222 by applying a force; while in this embodiment, the lock and release device 123 focuses on locking the potential energy storage and release component 1222 by a non-liquid path locking method.

[0180] Specifically, the sample analysis system 10 provided in this embodiment includes a sample input device 400, a liquid chromatography analyzer 100, a blood cell analyzer 200, a sample transmission device 300, an information acquisition device 600, and a control component 500. The sample input device 400 is at least used for placing a sample container loaded with a blood sample to achieve the sampling of the blood sample. The liquid chromatography analyzer 100 is used to aspirate the blood sample from the sample container and perform chromatographic analysis on at least part of the aspirated blood sample. The blood cell analyzer 200 is used to aspirate the blood sample from the sample container and perform blood cell analysis on at least part of the aspirated blood sample. The sample transmission device 300 includes a first transmission track 310 and a second transmission track 320. The first transmission track 310 is used to transmit the sample container from the sample input device 400 to the liquid chromatography analyzer 100, and the second transmission track 320 is used to transmit the sample container from the sample input device 400 to the blood cell analyzer 200. The first transmission track 310 and the second transmission track 320 are integrally formed or connected to each other. The information acquisition device 600 is used to acquire information characterizing the type of test item of the blood sample in the sample container. The control component 500 is configured to: determine the type of test item of the sample in the sample container according to the information fed back by the information acquisition device 600 characterizing the type of test item of the sample in the sample container; and control the sample transmission device 300 to transmit the sample container to the liquid chromatography analyzer 100 and / or the blood cell analyzer 200 for sampling according to the type of test item of the sample in the sample container. Among them, the liquid chromatography analyzer 100 includes a sample supply component 110, a liquid phase fluid supply component 120, a switching valve 130, a sample liquid preparation channel 140, a chromatography column 150, and a detector 160. The switching valve 130 has a switchable first connection state and a second connection state: in the first connection state, the switching valve 130 connects the sample supply component 110 and the sample liquid preparation channel 140 and connects the liquid phase fluid supply component 120 and the chromatography column 150; in the second connection state, the switching valve 130 connects the liquid phase fluid supply component 120, the sample liquid preparation channel 140, and the chromatography column 150. The chromatography column 150 is connected between the switching valve 130 and the detector 160. The sample supply component 110 is used to aspirate the blood sample from the sample container and supply a first sample liquid made of at least part of the aspirated blood sample to the sample liquid preparation channel 140 through the switching valve 130. The liquid phase fluid supply component 120 is used to drive the first sample liquid in the sample liquid preparation channel 140 to be transported to the chromatography column 150 by the liquid phase fluid, and is used to drive the liquid phase fluid to flow through the switching valve 130 and the chromatography column 150 in sequence. The chromatography column 150 is used to adsorb the first sample liquid and is used to allow the liquid phase fluid to elute the first sample liquid to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatography column 150.The liquid-phase fluid supply assembly 120 includes a first driving device 121 and an energy storage device. The energy storage device includes an energy storage component 122 and a locking and releasing device 123. The first driving device 121 is used to drive the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150. The energy storage component 122 is disposed between the first driving device 121 and the switching valve 130. The energy storage component 122 includes a housing 1221 and a potential energy storage and release assembly 1222. At least a part of the potential energy storage and release assembly 1222 is disposed inside the housing 1221 and forms a liquid chamber 1223 for the liquid-phase fluid to flow through inside the housing 1221. At least a part of the potential energy storage and release assembly 1222 can move relative to the housing 1221 to change the size of the liquid chamber 1223 and store potential energy or release the stored potential energy.

[0181] As an implementation manner, the locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device 123 locks the potential energy storage and release assembly 1222 in a non-liquid path locking manner, thereby preventing it from moving relative to the housing 1221 to prevent the potential energy storage and release assembly 1222 from releasing the stored potential energy; in the released state, the potential energy storage and release assembly can move relative to the housing 1221 under the pressure action of the liquid-phase fluid to store potential energy, and the locking and releasing device 123 releases the potential energy storage and release assembly 1222 in a non-liquid path conducting manner, thereby allowing the potential energy storage and release assembly 1222 to release the stored potential energy. The control assembly 500 is further configured to: during the process of executing a chromatographic analysis project, control the first driving device 121 to drive the liquid-phase fluid to flow to elute the first sample liquid adsorbed on the chromatography column 150, and control the locking and releasing device 123 to be in the released state to allow the potential energy storage and release assembly 1222 to move relative to the housing 1221 under the pressure action of the liquid-phase fluid to store potential energy; within a first preset time period after completing the chromatographic analysis project of a blood sample, if no information about other blood samples that need to execute the chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the released state to the locked state to prevent the potential energy storage and release assembly 1222 from moving relative to the housing 1221 and thus prevent it from releasing the stored potential energy, and control the first driving device 121 to stop driving the liquid-phase fluid to flow; after the locking and releasing device 123 switches to the locked state, if information about a blood sample that needs to execute the chromatographic analysis project is obtained, control the locking and releasing device 123 to switch from the locked state to the released state, so that the potential energy storage and release assembly 1222 can move relative to the housing 1221 to release the stored potential energy to assist in driving the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150.

[0182] As an implementation manner, the potential energy storage and release assembly 1222 has a clamping portion 1222d extending outside the housing 1221. The locking and releasing device 123 locks the potential energy storage and release assembly 1222 by abutting and limiting the clamping portion 1222d, and the locking and releasing device 123 releases the potential energy storage and release assembly 1222 by disengaging to release the clamping portion 1222d.

[0183] As an implementation manner, the locking and releasing device 123 includes a power component 1231, a locking component 1232, and a transmission component 1233 that is transmission-connected between the power component 1231 and the locking component 1232. The transmission component 1233 has a self-locking ability. When the locking and releasing device 123 is in the locked state, the power component 1231 is in a stopped operating state, and the locking component 1232 is held in the locked position by the locking force generated by the self-locking of the transmission component 1233 to abut against the locking potential energy storage and release assembly 1222.

[0184] Except for the above, other parts of the energy storage device, the sample analysis system 10, the liquid chromatography analyzer 100, and the control method of the liquid chromatography analyzer 100 provided in this embodiment can refer to Embodiment 1 and will not be elaborated here.

[0185] Embodiment 4:

[0186] The energy storage device, the sample analysis system 10, the liquid chromatography analyzer 100, and the control method of the liquid chromatography analyzer 100 provided in this embodiment are mainly different from those in Embodiment 1 in terms of the protection focus, specifically reflected in: in Embodiment 1, the focus is on protecting the control timing of the pressure re-building locking and releasing device 123 in the intermittent sampling scenario; while in this embodiment, the focus is on protecting the immediate measurement solution for samples in the intermittent sampling scenario.

[0187] Specifically, the sample analysis system 10 provided in this embodiment includes a sample input device 400, a liquid chromatography analyzer 100, a blood cell analyzer 200, a sample transmission device 300, an information acquisition device 600, and a control component 500. The sample input device 400 is at least used for placing a sample container loaded with a blood sample to achieve the sampling of the blood sample. The liquid chromatography analyzer 100 is used to aspirate the blood sample from the sample container and perform chromatographic analysis on at least part of the aspirated blood sample. The blood cell analyzer 200 is used to aspirate the blood sample from the sample container and perform blood cell analysis on at least part of the aspirated blood sample. The sample transmission device 300 includes a first transmission track 310 and a second transmission track 320. The first transmission track 310 is used to transmit the sample container from the sample input device 400 to the liquid chromatography analyzer 100, and the second transmission track 320 is used to transmit the sample container from the sample input device 400 to the blood cell analyzer 200. The first transmission track 310 and the second transmission track 320 are integrally formed or connected to each other. The information acquisition device 600 is used to acquire information characterizing the type of test item of the blood sample in the sample container. The control component 500 is configured to: determine the type of test item of the blood sample in the sample container according to the information characterizing the type of test item of the blood sample in the sample container fed back by the information acquisition device 600; and control the sample transmission device 300 to transmit the sample container to the liquid chromatography analyzer 100 and / or the blood cell analyzer 200 for sample aspiration according to the type of test item of the blood sample in the sample container.

[0188] As an implementation manner, the liquid chromatography analyzer 100 includes a sample supply component 110, a liquid phase fluid supply component 120, a switching valve 130, a sample liquid preparation channel 140, a chromatography column 150, and a detector 160. The switching valve 130 has a switchable first connection state and second connection state: in the first connection state, the switching valve 130 connects the sample supply component 110 and the sample liquid preparation channel 140 and connects the liquid phase fluid supply component 120 and the chromatography column 150; in the second connection state, the switching valve 130 connects the liquid phase fluid supply component 120, the sample liquid preparation channel 140, and the chromatography column 150. The chromatography column 150 is connected between the switching valve 130 and the detector 160. The sample supply component 110 is used to aspirate the blood sample from the sample container and supply a first sample liquid made of at least part of the aspirated blood sample to the sample liquid preparation channel 140 through the switching valve 130. The liquid phase fluid supply component 120 is used to drive the first sample liquid in the sample liquid preparation channel 140 to be transported to the chromatography column 150 by the liquid phase fluid, and is used to drive the liquid phase fluid to flow through the switching valve 130 and the chromatography column 150 in sequence. The chromatography column 150 is used to adsorb the first sample liquid and is used to allow the liquid phase fluid to elute the first sample liquid to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatography column 150.

[0189] As an implementation manner, the liquid-phase fluid supply assembly 120 includes a first driving device 121 and an energy storage device. The energy storage device includes an energy storage component 122 and a locking and releasing device 123. The first driving device 121 is configured to drive the liquid-phase fluid to flow towards the switching valve 130 and the chromatography column 150. The energy storage component 122 is disposed between the first driving device 121 and the switching valve 130. The energy storage component 122 includes a housing 1221 and a potential energy storage and release assembly 1222. The potential energy storage and release assembly 1222 is at least partially disposed within the housing 1221 and forms a liquid chamber 1223 for the liquid-phase fluid to flow through within the housing 1221. At least a part of the potential energy storage and release assembly 1222 is capable of moving relative to the housing 1221 to change the size of the liquid chamber 1223 and store potential energy or release the stored potential energy. The locking and releasing device 123 can be switched between a locked state and a released state.

[0190] As an implementation manner, the control assembly 500 is further configured to: during the execution of the chromatographic analysis project, control the first driving device 121 to drive the liquid-phase fluid to flow to elute the first sample liquid adsorbed on the chromatography column 150, and control the locking and releasing device 123 to be in the released state to allow the potential energy storage and release assembly 1222 to move relative to the housing 1221 under the pressure action of the liquid-phase fluid to store potential energy; within a first preset time period after the completion of the chromatographic analysis project of a blood sample, if no information about other blood samples that need to execute the chromatographic analysis project is obtained, then control the locking and releasing device 123 to switch from the released state to the locked state to prevent the potential energy storage and release assembly 1222 from moving relative to the housing 1221, thereby preventing it from releasing the stored potential energy, and control the first driving device 121 to stop driving the liquid-phase fluid to flow. When the locking and releasing device 123 is in the locked state and the switching valve 130 is in the first communication state, if information about a blood sample that needs to execute the chromatographic analysis project is obtained, then control the sample supply assembly 110 to perform the following sample liquid preparation actions: suck a blood sample from the sample container and distribute it to the reaction container 112, and convey the first sample liquid made of at least the blood sample and the hemolytic agent in the reaction container 112 to the sample preparation channel through the switching valve 130. During the process of the sample supply assembly 110 performing the sample liquid preparation actions, control the first driving device 121 to start and operate, control the locking and releasing device 123 to switch from the locked state to the released state, so that the potential energy storage and release assembly 1222 moves relative to the housing 1221 to release the stored potential energy to assist in driving the liquid-phase fluid to flow towards the switching valve 130 and the chromatography column 150. After the sample supply assembly 110 finishes performing the sample liquid preparation actions, control the switching valve 130 to switch from the first communication state to the second communication state, so that the liquid-phase fluid supply assembly 120 drives the first sample liquid in the sample preparation channel 140 to be conveyed to the chromatography column 150 through the liquid-phase fluid.

[0191] As an implementation manner, the control component 500 is further configured to control the sample supply component 110 to complete the following sample liquid preparation actions within a fifth preset time period: suck a blood sample from a sample container and distribute it to the reaction container 112, and convey a first sample liquid made of at least the blood sample and a hemolytic agent in the reaction container 112 to the sample preparation channel through the switching valve 130; when the locking and releasing device 123 is in the locked state, if information indicating that a blood sample needs to perform a chromatographic analysis item is obtained, control the liquid-phase fluid supply component 120 to complete the following pressure building actions within a sixth preset time period: control the first driving device 121 to start and operate, and control the locking and releasing device 123 to switch from the locked state to the released state, so that the pressure of the liquid-phase fluid supplied by the liquid-phase fluid supply component 120 flowing to the chromatography column 150 reaches a target pressure value or a target pressure range within the fifth preset time period; during the process of performing the chromatographic analysis item, control the first driving device 121 to drive the liquid-phase fluid to flow at a target pressure value or a pressure value within the target pressure range to elute the first sample liquid adsorbed on the chromatography column 150; the sixth preset time period is less than the fifth preset time period.

[0192] As an implementation manner, the control component is further configured to: before performing the first chromatographic analysis item after the liquid chromatograph 100 is powered on, first control the first driving device 121 to start and operate for a third preset time period, so that the pressure of the liquid-phase fluid flowing to the chromatography column 150 reaches a target pressure value or a target pressure range. The sixth preset time period is less than the third preset time period.

[0193] Except for the above, for other parts of the energy storage device, the sample analysis system 10, the liquid chromatograph 100, and the control method of the liquid chromatograph 100 provided in this embodiment, reference can be made to Embodiments 1 to 3, which will not be elaborated here.

[0194] Embodiment 5:

[0195] The main difference between the energy storage device, the sample analysis system 10, the liquid chromatograph 100, and the control method of the liquid chromatograph 100 provided in this embodiment and Embodiment 1 is that this embodiment does not limit the timing control of the pressure building process, and only needs to ensure that the energy storage device 122 and the locking and releasing device 123 are provided in the liquid-phase fluid supply component 120.

[0196] Specifically, the sample analysis system 10 provided in this embodiment includes a sample input device 400, a liquid chromatography analyzer 100, a blood cell analyzer 200, a sample transfer device 300, an information acquisition device 600, and a control component 500. The sample input device 400 is at least used for placing a sample container loaded with a blood sample to achieve the loading of the blood sample. The liquid chromatography analyzer 100 is used to aspirate the blood sample from the sample container and perform chromatographic analysis on at least part of the aspirated blood sample. The blood cell analyzer 200 is used to aspirate the blood sample from the sample container and perform blood cell analysis on at least part of the aspirated blood sample. The sample transfer device 300 includes a first transfer track 310 and a second transfer track 320. The first transfer track 310 is used to transfer the sample container from the sample input device 400 to the liquid chromatography analyzer 100, and the second transfer track 320 is used to transfer the sample container from the sample input device 400 to the blood cell analyzer 200. The first transfer track 310 and the second transfer track 320 are integrally formed or connected to each other. The information acquisition device 600 is used to acquire information characterizing the type of the test item of the blood sample in the sample container. The control component 500 is configured to: determine the type of the test item of the blood sample in the sample container according to the information characterizing the type of the test item of the blood sample in the sample container fed back by the information acquisition device 600; and control the sample transfer device 300 to transfer the sample container to the liquid chromatography analyzer 100 and / or the blood cell analyzer 200 for sample aspiration according to the type of the test item of the blood sample in the sample container.

[0197] As an implementation manner, the liquid chromatography analyzer 100 includes a sample supply component 110, a liquid phase fluid supply component 120, a switching valve 130, a sample liquid preparation channel 140, a chromatography column 150, and a detector 160. The switching valve 130 has a switchable first communication state and second communication state: in the first communication state, the switching valve 130 connects the sample supply component 110 and the sample liquid preparation channel 140 and connects the liquid phase fluid supply component 120 and the chromatography column 150; in the second communication state, the switching valve 130 connects the liquid phase fluid supply component 120, the sample liquid preparation channel 140, and the chromatography column 150. The chromatography column 150 is connected between the switching valve 130 and the detector 160. The sample supply component 110 is used to aspirate the blood sample from the sample container and supply a first sample liquid made from at least part of the aspirated blood sample to the sample liquid preparation channel 140 through the switching valve 130. The liquid phase fluid supply component 120 is used to drive the first sample liquid in the sample liquid preparation channel 140 to be transported to the chromatography column 150 by the liquid phase fluid, and is used to drive the liquid phase fluid to flow through the switching valve 130 and the chromatography column 150 in sequence. The chromatography column 150 is used to adsorb the first sample liquid and is used to allow the liquid phase fluid to elute the first sample liquid to form a test solution. The detector 160 is used to perform chromatographic analysis on the test solution flowing out of the chromatography column 150.

[0198] As an implementation manner, the liquid-phase fluid supply assembly 120 includes a first driving device 121 and an energy storage device. The energy storage device includes an energy storage component 122 and a locking and releasing device 123. The first driving device 121 is used to drive the liquid-phase fluid to flow toward the switching valve 130 and the chromatography column 150. The energy storage component 122 is disposed between the first driving device 121 and the switching valve 130. The energy storage component 122 includes a housing 1221 and a potential energy storage and release assembly 1222. At least a part of the potential energy storage and release assembly 1222 is disposed inside the housing 1221 and forms a liquid chamber 1223 for the liquid-phase fluid to flow through inside the housing 1221. At least a part of the potential energy storage and release assembly 1222 can move relative to the housing 1221 to change the size of the liquid chamber 1223 and store potential energy or release the stored potential energy.

[0199] As an implementation manner, the locking and releasing device 123 can switch between a locked state and a released state: in the locked state, the locking and releasing device applies a force to the potential energy storage and release assembly to lock the potential energy storage and release assembly 1222, thereby preventing it from moving relative to the housing 1221 and preventing the potential energy storage and release assembly from releasing the stored potential energy; in the released state, the potential energy storage and release assembly can move relative to the housing 1221 under the action of the fluid pressure to store potential energy, and, when the locking and releasing device removes the force applied to the potential energy storage and release assembly, the potential energy storage and release assembly is released, thereby allowing the potential energy storage and release assembly to move relative to the housing 1221 to allow the potential energy storage and release assembly to release the stored potential energy.

[0200] As an implementation manner, the locking and releasing device 123 applies a force to the potential energy storage and release assembly 1222 to lock the potential energy storage and release assembly 1222 by abutting against the potential energy storage and release assembly 1222, and the locking and releasing device 123 removes the force applied to the potential energy storage and release assembly 1222 to release the potential energy storage and release assembly 1222 by disengaging from the potential energy storage and release assembly 1222.

[0201] As an implementation manner, the locking and releasing device 123 applies a force to the potential energy storage and release assembly 1222 to lock the potential energy storage and release assembly 1222 by a non-liquid path locking method, and the locking and releasing device 123 removes the force applied to the potential energy storage and release assembly 1222 to release the potential energy storage and release assembly 1222 by a non-liquid path conducting method.

[0202] Except for the above, for other parts of the energy storage device, the sample analysis system 10, the liquid chromatography analyzer 100, and the control method of the liquid chromatography analyzer 100 provided in this embodiment, reference can be made to Embodiments 1 to 4, which will not be elaborated here.

[0203] The above are only the preferred embodiments of the present invention, and do not limit the patent scope of the present invention accordingly. Any equivalent structural transformation made under the inventive concept of the present invention by using the content of the specification and drawings of the present invention, or any direct / indirect application in other related technical fields, is included in the patent protection scope of the present invention.

Claims

1. An energy storage device, characterized in that: include: An energy storage device, the energy storage device comprising a shell and a potential energy storage and release component, the potential energy storage and release component is at least partially disposed in the shell and is separated in the shell to form a liquid cavity for a liquid phase fluid to flow through, and at least partially the potential energy storage and release component can move relative to the shell to change the size of the liquid cavity and store potential energy or release the stored potential energy; A locking and releasing device, which can be switched between a locked state and a released state: in the locked state, the locking and releasing device applies a force to the potential energy storage and release component to lock the potential energy storage and release component, thereby preventing the potential energy storage and release component from moving relative to the shell, thereby preventing the potential energy storage and release component from releasing the stored potential energy; in the released state, the potential energy storage and release component can move relative to the shell under the pressure of the liquid phase fluid to store potential energy, and, when the locking and releasing device removes the force applied to the potential energy storage and release component, the potential energy storage and release component is released, thereby allowing the potential energy storage and release component to move relative to the shell, thereby allowing the potential energy storage and release component to release the stored potential energy.

2. The energy storage device according to claim 1, wherein: The potential energy stored and released by the potential energy storage and release component is elastic potential energy; or, The potential energy stored and released by the potential energy storage and release component is gravitational potential energy; or, The potential energy stored and released by the potential energy storage and release component is the internal energy of the gas.

3. The energy storage device according to claim 1, wherein: The locking and releasing device applies the force to the potential energy storage and release component by abutting against the potential energy storage and release component to lock the potential energy storage and release component, and the locking and releasing device removes the force applied to the potential energy storage and release component by disengaging from the potential energy storage and release component to release the potential energy storage and release component.

4. The energy storage device according to claim 1, wherein: The locking and releasing device applies the force to the potential energy storage and release component in a non-liquid locking manner to lock the potential energy storage and release component, and the locking and releasing device removes the force applied to the potential energy storage and release component in a non-liquid conduction manner to release the potential energy storage and release component.

5. The energy storage device according to any one of claims 1 to 4, characterized in that: The potential energy storage and release component has a locking portion extending outside the housing, and the locking and releasing device applies the force to the potential energy storage and release component by limiting the locking portion, so as to lock the potential energy storage and release component; The locking and releasing device removes the force applied to the potential energy storage and release component by releasing the locking portion, so as to release the potential energy storage and release component.

6. The energy storage device according to claim 1, characterized in that: The locking and releasing device comprises a power component, a locking component and a transmission component which is transmission-connected between the power component and the locking component; When the lock-and-release device is in the locked state, the locking component is in a locked position to lock the potential energy storage-and-release component. In the locked position, the locking component abuts against the potential energy storage-and-release component.

7. The energy storage device according to claim 6, characterized in that: The transmission component has a self-locking capability. When the lock-release device is in the locked state, the power component is in a stopped state, and the locking component is in a locked position by the locking force generated by the self-locking of the transmission component to lock the potential energy storage and release component.

8. The energy storage device according to claim 7, characterized in that: The power component is a motor; When the lock-release device is in the locked state, the motor is in a stopped state, and the locking member is in a locked position by the locking force generated by the self-locking of the transmission member to lock the potential energy storage and release assembly; When the lock-release device is in the released state, the motor is in a stopped state, and the locking member is in an unlocked position to release the potential energy storage and release assembly. In the unlocked position, the locking member disengages from the potential energy storage and release assembly; During the process of the lock-release device switching from the locked state to the released state, the motor is in an operating state to drive the locking member from the locked position to the unlocked position through the transmission member; During the process of the lock-release device switching from the released state to the locked state, the motor is in an operating state to drive the locking member from the unlocked position to the locked position through the transmission member.

9. The energy storage device according to claim 8, wherein: The potential energy storage and release assembly has a clamping portion extending outside the housing, and the clamping portion has a clamping end face facing the liquid chamber; The locking member is formed with a locking portion, and the locking portion is configured to move between the locked position and the unlocked position under the drive of the power member and the transmission member; When the power member starts and operates to drive the transmission member to drive the locking portion to move from the unlocked position to the locked position, the locking portion abuts against the clamping end face; After the locking portion moves to the locked position, the power member stops operating so that the locking portion is held in the locked position under the action of the locking force generated by the self-locking of the transmission member; When the power member starts and operates to drive the transmission member to drive the locking portion to move from the locked position to the unlocked position, the locking portion disengages from the clamping end face, so that the potential energy storage and release assembly releases the stored potential energy and moves toward the liquid chamber to drive the liquid-phase fluid in the liquid chamber to flow out of the liquid chamber; 10. The energy storage device according to claim 9, wherein: The lock-release device further includes a detection component, and the detection component is configured to detect whether the locking portion is located at the locked position; During the process of the power member driving the transmission member to drive the locking portion to move from the unlocked position to the locked position, when the detection component detects that the locking portion moves to the locked position, the power member stops operating.

11. The energy storage device according to claim 10, wherein: The detection component is a reflective photoelectric sensor or an opposed photoelectric sensor or a proximity switch.

12. The energy storage device according to claim 10, characterized in that: The potential energy stored and released by the potential energy storage and release assembly is elastic potential energy; The potential energy storage and release assembly includes a diaphragm, an elastic element and a guide rod. The diaphragm is disposed inside the housing and cooperates with the inner wall of the housing to form the liquid chamber. One end of the guide rod is connected to the diaphragm, and the other end of the guide rod extends outside the housing and forms the clamping portion. The elastic element is located inside the housing and sleeved on the guide rod; The lock-release device being in the locked state includes: the locking portion abutting against the clamping portion to lock the clamping portion, so that the elastic element stores the elastic potential energy; The lock-and-release device being in the release state includes: the locking portion being disengaged from the locking portion to release the locking portion, thereby allowing the elastic element to release the elastic potential energy.

13. The energy storage device according to claim 12, wherein: The stiffness of the elastic element is greater than or equal to 500 N / mm and less than or equal to 30000 N / mm; and / or, The elastic element includes at least one pair of disc spring groups.

14. The energy storage device according to any one of claims 6 to 13, characterized in that: The transmission component comprises a screw transmission pair, the thread lead angle of the screw transmission pair is smaller than the equivalent friction angle; and / or, The transmission component comprises a screw transmission pair, and the screw transmission pair is a trapezoidal screw transmission pair.

15. An energy storage device, characterized in that: include: An energy storage device, the energy storage device comprising a shell and a potential energy storage and release component, the potential energy storage and release component is at least partially disposed in the shell and is separated in the shell to form a liquid cavity for a liquid phase fluid to flow through, and at least partially the potential energy storage and release component can move relative to the shell to change the size of the liquid cavity and store potential energy or release the stored potential energy; A locking and releasing device, which can be switched between a locked state and a released state: in the locked state, the locking and releasing device abuts against the potential energy storage and release component to lock the potential energy storage and release component, thereby preventing it from moving relative to the shell, so as to prevent the potential energy storage and release component from releasing the stored potential energy; in the released state, the potential energy storage and release component can move relative to the shell through the pressure of the liquid fluid to store potential energy, and, when the locking and releasing device is separated from the potential energy storage and release component, the potential energy storage and release component is released, thereby allowing the potential energy storage and release component to move relative to the shell, so as to allow the potential energy storage and release component to release the stored potential energy.

16. The energy storage device according to claim 15, characterized in that: The potential energy storage and release component has a locking portion extending outside the housing, the locking and releasing device locks the potential energy storage and release component by abutting and limiting the locking portion, and the locking and releasing device releases the potential energy storage and release component by disengaging to release the locking portion; and / or, The locking and releasing device comprises a power component, a locking component and a transmission component which is transmission-connected between the power component and the locking component, wherein the transmission component has a self-locking capability. When the locking and releasing device is in the locked state, the power component is in a stopped state, and the locking component is in a locked position by a locking force generated by the self-locking of the transmission component to abut and lock the potential energy storage and release component.

17. An energy storage device, characterized in that: include: An energy storage device, the energy storage device comprising a shell and a potential energy storage and release component, the potential energy storage and release component is at least partially disposed in the shell and is separated in the shell to form a liquid cavity for a liquid phase fluid to flow through, and at least partially the potential energy storage and release component can move relative to the shell to change the size of the liquid cavity and store potential energy or release the stored potential energy; A locking and releasing device, which can be switched between a locked state and a released state: in the locked state, the locking and releasing device locks the potential energy storage and release component by a non-liquid path locking method, thereby preventing it from moving relative to the shell, so as to prevent the potential energy storage and release component from releasing the stored potential energy; in the released state, the potential energy storage and release component can move relative to the shell through the pressure of the liquid phase fluid to store potential energy, and the locking and releasing device releases the potential energy storage and release component by a non-liquid path conduction method, thereby allowing the potential energy storage and release component to release the stored potential energy.

18. The energy storage device according to claim 17, wherein: The potential energy storage and release component has a locking portion extending outside the housing, the locking and releasing device locks the potential energy storage and release component by abutting and limiting the locking portion, and the locking and releasing device releases the potential energy storage and release component by disengaging to release the locking portion; and / or, The locking and releasing device comprises a power component, a locking component and a transmission component which is transmission-connected between the power component and the locking component, wherein the transmission component has a self-locking capability. When the locking and releasing device is in the locked state, the power component is in a stopped state, and the locking component is in a locked position by a locking force generated by the self-locking of the transmission component to abut and lock the potential energy storage and release component.

19. A sample analysis system, characterized in that: include: A sample input device, the sample input device is at least used for receiving a sample container loaded with a blood sample, so as to achieve the loading of the blood sample; A liquid chromatograph analyzer, the liquid chromatograph analyzer is used to draw a blood sample from a sample container and perform chromatographic analysis on at least a portion of the drawn blood sample; A blood cell analyzer, the blood cell analyzer is used to draw a blood sample from a sample container and perform a blood cell analysis on at least a portion of the drawn blood sample; A sample transmission device, the sample transmission device comprising a first transmission track and a second transmission track, the first transmission track is used to transmit the sample container from the sample input device to the liquid chromatograph analyzer, the second transmission track is used to transmit the sample container from the sample input device to the blood cell analyzer, the first transmission track and the second transmission track are integrally formed or connected to each other; An information acquisition device, the information acquisition device is used to acquire information characterizing the type of the item to be tested of the blood sample in the sample container; A control component, wherein the control component is configured to: determine the type of the item to be tested of the blood sample in the sample container according to the information characterizing the type of the item to be tested of the blood sample in the sample container fed back by the information acquisition device; and control the sample transmission device to transmit the sample container to the liquid chromatograph analyzer and / or the blood cell analyzer for sample aspiration according to the type of the item to be tested of the blood sample in the sample container; Among them, the liquid chromatography analyzer includes a sample supply component, a liquid-phase fluid supply component, a switching valve, a sample liquid preparation channel, a chromatography column, and a detector. The chromatography column is connected between the switching valve and the detector. The switching valve has a switchable first connection state and a second connection state: in the first connection state, the switching valve connects the sample supply component and the sample liquid preparation channel and connects the liquid-phase fluid supply component and the chromatography column; in the second connection state, the switching valve connects the liquid-phase fluid supply component, the sample liquid preparation channel, and the chromatography column; The sample supply component is used to suck a blood sample from a sample container and supply a first sample liquid made from at least a part of the sucked blood sample to the sample liquid preparation channel through the switching valve; The liquid-phase fluid supply component is used to drive the first sample liquid in the sample liquid preparation channel to be transported to the chromatography column by the liquid-phase fluid, and is used to drive the liquid-phase fluid to flow through the switching valve and the chromatography column in sequence; The chromatography column is used to adsorb the first sample liquid and is used to allow the liquid-phase fluid to elute the first sample liquid to form a liquid to be measured; The detector is used to perform chromatographic analysis on the liquid to be measured flowing out of the chromatography column; The liquid-phase fluid supply component includes a first driving device and the energy storage device according to any one of claims 1 to 18. The first driving device is used to drive the liquid-phase fluid to flow towards the switching valve and the chromatography column. The energy storage device is arranged between the first driving device and the switching valve.

20. A liquid chromatography analyzer, characterized in that: It includes a sample supply component, a liquid-phase fluid supply component, a switching valve, a sample liquid preparation channel, a chromatography column, and a detector. The chromatography column is connected between the switching valve and the detector. The switching valve has a switchable first connection state and a second connection state: in the first connection state, the switching valve connects the sample supply component and the sample liquid preparation channel and connects the liquid-phase fluid supply component and the chromatography column; in the second connection state, the switching valve connects the liquid-phase fluid supply component, the sample liquid preparation channel, and the chromatography column; The sample supply component is used to suck a blood sample from a sample container and supply a first sample liquid made from at least a part of the sucked blood sample to the sample liquid preparation channel through the switching valve; The liquid-phase fluid supply component is used to drive the first sample liquid in the sample liquid preparation channel to be transported to the chromatography column by the liquid-phase fluid, and is used to drive the liquid-phase fluid to flow through the switching valve and the chromatography column in sequence; The chromatography column is used to adsorb the first sample liquid and is used to allow the liquid-phase fluid to elute the first sample liquid to form a liquid to be measured; The detector is used to perform chromatographic analysis on the liquid to be measured flowing out of the chromatography column; The liquid-phase fluid supply assembly includes a first driving device and an energy storage device as described in any one of claims 1 to 18. The first driving device is used to drive the liquid-phase fluid to flow toward the reversing valve and the chromatography column, and the energy storage device is disposed between the first driving device and the reversing valve.

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