Sample analyzer

Abstract

The invention discloses a sample analyzer which comprises a sample supply mechanism, a sample separate injection mechanism, a reagent supply mechanism, a reagent separate injection mechanism and a determination mechanism. Wherein the reagent supply mechanism comprises a reagent container transfer device with a three-dimensional movement device and a clamping device. The reagent containers are transferred through the three-dimensional movement device and the clamping device, gaps for movement of the reagent container transfer device do not need to be reserved between the reagent containers, the gaps between the reagent containers are as small as possible, and therefore the reagent supply mechanism can contain more reagent containers.

Description

Technical Field

[0001] The present invention relates to the field of sample analysis, and particularly to a sample analyzer. Background Art

[0002] In the reagent storage mechanism of the reagent cartridge type in the existing sample analyzer, there is a gap between two adjacent reagent containers. The gap is used for the transfer of the transfer reagent container to pass through. Therefore, the gap will occupy the position of the reagent container, resulting in a smaller number of reagent containers that can be accommodated in the reagent storage mechanism. Summary of the Invention

[0003] The first object of the present invention is to provide a solution that aims to solve the technical problem of the smaller number of reagent containers stored in the reagent supply mechanism.

[0004] To achieve the above object, the solution provided by the present invention is: a sample analyzer, comprising:

[0005] A sample supply mechanism for supplying a sample;

[0006] A sample dispensing mechanism for dispensing the sample into a reaction cup;

[0007] A reagent supply mechanism for supplying a reagent;

[0008] A reagent dispensing mechanism for sucking the reagent in the reagent container at the suction level and discharging the sucked reagent into the reaction cup at the discharge level;

[0009] A measurement mechanism for measuring the test solution made of at least the sample and the reagent in the reaction cup to obtain a measurement result;

[0010] Wherein, the reagent supply mechanism includes:

[0011] A storage member provided with a plurality of reagent storage positions for placing reagent containers. The plurality of reagent storage positions are arranged in a first direction, and at least two reagent storage positions are stacked in the vertical direction. The first direction is different from the vertical direction;

[0012] A first reagent container transfer device for transferring the reagent container stored in the reagent storage position to the suction level, or a first reagent container transfer device and a second reagent container transfer device. The first reagent container transfer device is used to transfer the reagent container stored in the reagent storage position to a first position, and the second reagent container transfer device is used to transfer the reagent container between the first position and the suction level;

[0013] Among them, the first reagent container transfer device includes a clamping device and a three-dimensional motion device. The three-dimensional motion device is connected to the clamping device and is used to drive the clamping device to move in a three-dimensional space. The clamping device is used to clamp the reagent container to grab the reagent container and release the reagent container to put down the reagent container.

[0014] As an implementation manner, the three-dimensional motion device is used to drive the clamping device to move between a first station and a second station in a second direction. When the three-dimensional motion device moves to the first station, the clamping device can grab or put down the reagent container on the storage position. When the three-dimensional motion device moves to the second station, the three-dimensional motion device can move between the corresponding positions of each reagent storage position in the second direction. The second direction is different from the first direction and the vertical direction.

[0015] As an implementation manner, the three-dimensional motion device is further used to drive the clamping device to move in a first direction and a vertical direction. The first direction, the vertical direction, and the second direction are perpendicular to each other.

[0016] As an implementation manner, when the three-dimensional device is located at the second station, the clamping device is located outside the projection area of the reagent storage position in the vertical direction. When the three-dimensional device is located at the first station, at least a part of the clamping device is located within the projection area of the reagent storage position in the vertical direction.

[0017] As an implementation manner, the clamping device at least includes a main body part, a first clamping part, a second clamping part, and a clamping part driving mechanism. The main body part is connected to the three-dimensional motion device. The first clamping part, the second clamping part, and the clamping part driving mechanism are all connected to the main body part. The clamping part driving mechanism is used to drive the first clamping part and the second clamping part to move to complete clamping or releasing the reagent container. When the first clamping part and the second clamping part clamp the reagent container, they are in contact with the side surface of the reagent container.

[0018] As an implementation manner, a first convex part is provided on at least one of the abutting parts of the first clamping part and the second clamping part for abutting against the reagent container. The first convex part is used to cooperate with a first concave part provided on the reagent container to clamp the reagent container when clamping the reagent container. Or, a first concave part is provided on at least one of the abutting parts of the first clamping part and the second clamping part for abutting against the reagent container. The first concave part is used to cooperate with a first convex part provided on the reagent container to clamp the reagent container when clamping the reagent container.

[0019] As an embodiment, the storage component includes a support member, which forms the reagent storage position, and the support member includes a carrying surface for carrying the reagent container, the carrying surface is formed with a second convex portion that cooperates with the second concave portion at the bottom of the reagent container; or, a second concave portion that cooperates with the second convex portion at the bottom of the reagent container.

[0020] As an embodiment, the storage component includes a support member, which forms the reagent storage position, and a mixing structure is arranged on the support member, and the mixing structure is used to mix the magnetic bead reagent in the reagent container placed in the reagent storage position; the reagent supply mechanism also includes a power source that is transmission-connected to the mixing structure, and the power source provides power for the mixing mechanism to perform mixing.

[0021] As an embodiment, the mixing structure is provided on the support member corresponding to each of the reagent storage positions for placing reagent containers, and the same power source is connected to the mixing structures through a transmission component to drive the mixing structures to mix simultaneously.

[0022] As an embodiment, the reagent supply mechanism includes a shell, the shell forms a accommodating cavity, the storage component and the first reagent container transfer device are arranged in the accommodating cavity, the first position is located inside the accommodating cavity, the liquid aspiration position is located outside the accommodating cavity, the shell is provided with an opening, and the second reagent container transfer device transfers the reagent container between the first position and the liquid aspiration position through the opening.

[0023] As an embodiment, the second reagent container transfer component performs linear motion along the second direction, the reagent dispensing mechanism performs linear motion along the third direction, and the motion trajectory of the second reagent container transfer component intersects and is perpendicular to the motion trajectory of the reagent dispensing mechanism.

[0024] As an embodiment, the storage component includes at least two sub-storage components stacked in a vertical direction, the sub-storage components extend along a first direction and have multiple partitions arranged in the first direction, and multiple reagent storage positions arranged along the first direction are formed between the partitions.

[0025] As an implementation manner, the first direction is a horizontal direction perpendicular to the vertical direction.

[0026] A second object of the present invention is to provide a sample analyzer, comprising:

[0027] A sample supply mechanism, used for supplying samples;

[0028] A sample dispensing mechanism, used for dispensing samples into reaction cups;

[0029] A reagent supply mechanism for supplying reagents;

[0030] A reagent dispensing mechanism for sucking reagents from a reagent container at a suction liquid level and discharging the sucked reagents into a reaction cup at a discharge liquid level;

[0031] A measurement mechanism for measuring a test solution made of at least the sample and the reagent in the reaction cup to obtain a measurement result;

[0032] Among them, the reagent supply mechanism includes:

[0033] A storage member provided with a plurality of reagent storage positions for placing reagent containers, the plurality of reagent storage positions are arranged along a first horizontal direction, and at least two reagent storage positions are arranged along a second horizontal direction, and the first horizontal direction is different from the second horizontal direction;

[0034] A third reagent container transfer device for transferring the reagent container stored in the reagent storage position to the suction liquid level, or a third reagent container transfer device and a fourth reagent container transfer device, the third reagent container transfer device for transferring the reagent container stored in the reagent storage position of the storage member to a second position, and the fourth reagent container transfer device for transferring the reagent container between the second position and the suction liquid level;

[0035] Among them, the third reagent container transfer device includes a clamping device and a three-dimensional motion device, the three-dimensional motion device is connected to the clamping device and is used to drive the clamping device to move in three-dimensional space, and the clamping device is used to clamp the reagent container to grab the reagent container and release the reagent container to put down the reagent container.

[0036] As an implementation manner, the three-dimensional motion device is used to drive the clamping device to move between a third working position and a fourth working position in the vertical direction. When the three-dimensional motion device moves to the third working position, the clamping device can grab or put down the reagent container on the storage position. When the three-dimensional motion device moves to the fourth working position, the three-dimensional motion device can move between the corresponding positions of each reagent storage position in the vertical direction.

[0037] As an implementation manner, when the three-dimensional motion device is located at the third working position, the clamping device is located outside the projection area of the reagent storage position in the horizontal direction; when the three-dimensional motion device is located at the fourth working position, at least a part of the clamping device is located within the projection area of the reagent storage position in the horizontal direction.

[0038] The sample analyzer provided by the present invention transfers reagent containers through a three-dimensional motion device and a clamping device, without the need to reserve a gap for the reagent container transfer device between reagent containers, making the gap between reagent containers as small as possible, so that the reagent supply mechanism can accommodate a larger number of reagent containers. Description of the Drawings

[0039] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on the structures shown in these drawings.

[0040] Figure 1 is a schematic diagram of the sample analyzer provided by the embodiment of the present invention;

[0041] Figure 2 is a schematic structural diagram of the reagent supply mechanism provided by the embodiment of the present invention;

[0042] Figure 3 is a schematic structural diagram of the first reagent container transfer device provided by the embodiment of the present invention;

[0043] Figure 4 is a schematic structural diagram of the clamping device provided by the embodiment of the present invention;

[0044] Figure 5 is a schematic diagram when the clamping device provided by the embodiment of the present invention clamps a reagent container;

[0045] Figure 6 is Figure 5 a schematic cross-sectional view along A-A';

[0046] Figure 7 is a top view of the storage member provided by the embodiment of the present invention;

[0047] Figure 8 is a schematic structural diagram when the reagent container provided by the embodiment of the present invention is placed in the reagent storage position;

[0048] Figure 9 is a bottom view of the storage member provided by the embodiment of the present invention;

[0049] Figure 10 is a schematic structural diagram of the storage member provided by the embodiment of the present invention;

[0050] Figure 11 is a schematic structural diagram of the reagent supply mechanism provided by another embodiment of the present invention.

[0051] Explanation of the reference numerals in the attached drawings: 10. Sample analyzer; 11. Sample supply mechanism; 12. Sample dispensing mechanism; 13. Reagent supply mechanism; 131. Storage member; 1311. Support member; 1311a. Second convex portion; 1311b. Mixing structure; 1312. Sub-storage member; 1313. Partition; 132. First reagent container transfer device; 1321. Clamping device; 1321a. Main body member; 1321b. First clamping portion; 1321c. Second clamping portion; 1321d. Clamping portion driving mechanism; 1321e. First convex portion; 1322. Three-dimensional motion device; 1322a. First-direction motion member; 1322b. Vertical-direction motion member; 1322c. Second-direction motion member; 133. Second reagent container transfer device; 134. Power source; 135. Transmission member; 1351. Belt; 1352. Transfer rod; 136. Outer shell; 1361. Opening; 137. Third reagent container transfer device; 14. Reagent dispensing mechanism; 15. Measurement mechanism; 16. Incubation mechanism; 17. Magnetic separation mechanism; 20. Reagent container; 21. Second concave portion; 22. First concave portion. Detailed implementation manners

[0052] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts shall fall within the protection scope of the present invention.

[0053] It should be noted that all the directional indications (such as up, down, left, right, front, back...) in the embodiments of the present invention are only used to explain the relative position relationship and movement conditions between components in a specific posture. If the specific posture changes, the directional indications will also change accordingly.

[0054] It should also be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or there may be an intermediate element at the same time. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or indirectly connected to the other element through an intermediate element.

[0055] In addition, the descriptions involving "first", "second", etc. in the present invention are for descriptive purposes only, and should not be construed as indicating or implying their relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature. In addition, the technical solutions between various embodiments may be combined with each other, but it must be based on the fact that those of ordinary skill in the art can implement it. When the combination of technical solutions results in contradictions or cannot be implemented, it should be considered that such a combination of technical solutions does not exist and is not within the scope of protection required by the present invention.

[0056] Embodiment 1:

[0057] Please refer to Figure 1 , an embodiment of the present invention provides a sample analyzer 10, including a sample supply mechanism 11 for supplying samples; a sample dispensing mechanism 12 for dispensing samples into reaction vessels; a reagent supply mechanism 13 for supplying reagents; a reagent dispensing mechanism 14 for sucking the reagent in the reagent container 20 at the suction liquid level and discharging the sucked reagent into the reaction vessel at the discharge liquid level; and a measurement mechanism 15 for measuring the test liquid made of at least samples and reagents in the reaction vessel to obtain a measurement result.

[0058] In some embodiments, please refer to Figures 2 to 6 , the reagent supply mechanism 13 includes a storage member 131, the storage member 131 is provided with a plurality of reagent storage positions for placing the reagent containers 20, the plurality of reagent storage positions are arranged along a first direction, at least two reagent storage positions are stacked along the vertical direction, and the first direction is different from the vertical direction; a first reagent container transfer device 132, the first reagent container transfer device 132 is used to transfer the reagent container 20 stored in the reagent storage position to the suction liquid level. The first reagent container transfer device 132 includes a clamping device 1321 and a three-dimensional motion device 1322, the three-dimensional motion device 1322 is connected to the clamping device 1321 and is used to drive the clamping device 1321 to move in three-dimensional space, and the clamping device 1321 is used to clamp the reagent container 20 to grab the reagent container 20 and release the reagent container 20 to put down the reagent container 20. In the prior art, the gripper only makes two-dimensional movements in one horizontal direction and one vertical direction, and the gripper moves in the gap between adjacent reagent containers 20, and this gap causes waste of space, resulting in a reduction in the number of reagent containers 20 that can be accommodated. In this application, through the three-dimensional motion device 1322 and the clamping device 1321, the three-dimensional motion device 1322 drives the clamping device 1321 to move in three-dimensional space, so there is no need to use the gap between the reagent containers 20 to move, and thus the distance between the original adjacent two reagent containers 20 can be reduced to release space to accommodate more reagent containers 20.

[0059] In some embodiments, the reagent supply mechanism 13 includes a first reagent container transfer device 132 and a second reagent container transfer device 133. The first reagent container transfer device 132 is configured to transfer the reagent container stored at the reagent storage position to a first position, and the second reagent container transfer device 133 is configured to transfer the reagent container between the first position and the liquid suction position. The first reagent container transfer device 132 includes a clamping device 1321 and a three-dimensional motion device 1322. The three-dimensional motion device 1322 is connected to the clamping device 1321 and is configured to drive the clamping device 1321 to move in a three-dimensional space. The clamping device 1321 is configured to clamp the reagent container to grasp the reagent container and release the reagent container to put down the reagent container. In this application, through the three-dimensional motion device 1322 and the clamping device 1321, by driving the clamping device 1321 to move in a three-dimensional space by the three-dimensional motion device 1322, it is not necessary to utilize the gap between reagent containers to move, and thus the distance between two adjacent original reagent containers can be reduced to release space to accommodate more reagent containers 20.

[0060] In some embodiments, the reagent supply mechanism 13 includes a housing 136. The housing 136 forms an accommodation cavity. The storage member 131 is located in the accommodation cavity. The storage member 131 is fixedly connected to the housing 136 and remains fixed during the process of transferring the reagent container 20. In some embodiments, the storage members 131 are all disposed on the same inner side surface of the housing 136.

[0061] In some embodiments, the three-dimensional motion device 1322 is installed in the accommodation cavity and on the inner side surface of the housing 136.

[0062] In some embodiments, the directions in which the three-dimensional motion device 1322 drives the clamping device 1321 to move include a first direction, i.e., the arrangement direction of the reagent storage positions, a second direction, and a vertical direction. In some embodiments, both the first direction and the second direction are horizontal directions.

[0063] In some embodiments, the three-dimensional motion device 1322 includes a first-direction motion component 1322a, a second-direction motion component 1322c, and a vertical-direction motion component 1322b. The first-direction motion component 1322a is connected to the inner side surface of the housing 136. The first-direction motion component 1322a includes a slide rail, a driving source, and a transmission member. The slide rail of the first-direction motion component 1322a extends along the first direction. The transmission member is respectively connected to the vertical-direction motion component 1322b and the driving source of the first-direction motion component 1322a, and the vertical-direction motion component 1322b is slidably connected to the slide rail of the first-direction motion component 1322a, such that under the drive of the driving source of the first-direction motion component 1322a, the vertical-direction motion component 1322b moves along the first direction.

[0064] In some embodiments, the number of slide rails of the first-direction moving member 1322a is two, making the entire three-dimensional moving device 1322 more stable. The two slide rails are distributed in the vertical direction. The lower slide rail is lower than the lowest reagent storage position, and the upper slide rail is higher than the highest reagent storage position. The vertical-direction moving member 1322b is slidably connected to the upper and lower slide rails respectively. The vertical-direction moving member 1322b includes a main body portion, a guide rail, and a driving source. The main body portion of the vertical-direction moving member 1322b extends in the vertical direction, and both ends of the main body portion of the vertical-direction moving member 1322b are connected to the upper and lower guide rails respectively. The guide rail of the vertical-direction moving member 1322b extends in the vertical direction and is disposed on the main body portion of the vertical-direction moving member 1322b. The second-direction moving member 1322c is connected to the guide rail of the vertical-direction moving member 1322b and the driving source of the vertical-direction moving member 1322b. The driving source of the vertical-direction moving member 1322b drives the second-direction moving member 1322c to move in the vertical direction along the guide rail of the vertical-direction moving member 1322b. The second-direction moving member 1322c includes a main body portion, a guide rail, and a driving source. The main body portion of the second-direction moving member 1322c is connected to the guide rail of the vertical-direction moving member 1322b. The guide rail of the second-direction moving member 1322c extends in the second direction and is connected to the clamping device 1321 and the main body portion of the second-direction moving member 1322c respectively. The clamping device 1321 is also connected to the driving source of the second-direction moving member 1322c. Driven by the driving source of the second-direction moving member 1322c, the clamping device 1321 moves in the second direction along the guide rail of the second-direction moving member 1322c. In summary, the clamping device loaded on the three-dimensional moving device 1322 can move in the first direction, the second direction, and the vertical direction under the drive of the three-dimensional moving device 1322, that is, it can move in three-dimensional space.

[0065] In some embodiments, the three-dimensional moving device 1322 is used to drive the clamping device 1321 to move between a first station and a second station in the second direction; when the three-dimensional moving device 1322 moves to the first station, the clamping device 1321 can grasp or release the reagent container 20 on the storage position. When the three-dimensional moving device 1322 moves to the second station, the three-dimensional moving device 1322 can move between the corresponding positions of each reagent storage position in the second direction. The second direction is different from the first direction and the vertical direction. In some embodiments, the first direction, the second direction, and the vertical direction are perpendicular to each other.

[0066] In some embodiments, after the three-dimensional moving device 1322 moves from the first station to the second station along the second direction, it then moves along the second direction or the vertical direction from the second station. The corresponding position refers to a second station corresponding to each reagent storage position.

[0067] In some embodiments, the three-dimensional motion device 1322 is further configured to drive the clamping device 1321 to move in a first direction and a vertical direction, where the first direction, the vertical direction, and the second direction are perpendicular to each other, that is, both the first direction and the second direction are horizontal directions.

[0068] In some embodiments, when the three-dimensional device is at the second station, the clamping device 1321 is located outside the projection area of the reagent storage position in the vertical direction; when the three-dimensional device is at the first station, at least a part of the clamping device 1321 is located within the projection area of the reagent storage position in the vertical direction. When the three-dimensional device is at the second station, the movement of the clamping device does not interfere with the reagent storage position, and it can freely move to the corresponding positions of multiple reagent storage positions. Therefore, there is no need to reserve a gap for the movement of the clamping device between the reagent storage positions.

[0069] In some embodiments, the clamping device 1321 includes at least a main body member 1321a, a first clamping portion 1321b, a second clamping portion 1321c, and a clamping portion driving mechanism 1321d. The main body member 1321a is connected to the three-dimensional motion device 1322, and the first clamping portion 1321b, the second clamping portion 1321c, and the clamping portion driving mechanism 1321d are all connected to the main body member 1321a. The clamping portion driving mechanism 1321d is configured to drive the first clamping portion 1321b and the second clamping portion 1321c to move to clamp or release the reagent container 20. When the first clamping portion 1321b and the second clamping portion 1321c clamp the reagent container 20, they abut against the side surface of the reagent container 20. Clamping the reagent container 20 by the clamping device 1321 can make the reagent container 20 more stable during transportation, and at the same time, placing the reagent container 20 at other positions in a clamped manner by the clamping device 1321 is also more reliable.

[0070] In some embodiments, when the clamping device 1321 clamps or releases the reagent container 20, the first clamping portion 1321b and the second clamping portion 1321c move in the horizontal direction.

[0071] In some embodiments, a first convex portion 1321e is provided on the abutting portion of at least one of the first clamping portion 1321b and the second clamping portion 1321c for abutting against the reagent container 20. The first convex portion 1321e is configured to cooperate with a first concave portion 22 provided on the reagent container 20 to clamp the reagent container 20 when clamping the reagent container 20. Alternatively, first convex portions 1321e may be provided on the surfaces of the first clamping portion 1321b and the second clamping portion 1321c that abut against the reagent container 20 when clamping the reagent container 20. Similarly, the same number of first concave portions 22 are provided on the reagent container 20 to prevent the reagent container 20 from slipping during transfer.

[0072] In some embodiments, a first recess is provided on the abutting portion of at least one of the first clamping portion 1321b and the second clamping portion 1321c for abutting against the reagent container 20, and the first recess is used to cooperate with the first protrusion provided on the reagent container 20 to clamp the reagent container 20 when clamping the reagent container 20, that is, the first recess can be provided on at least one of the first clamping portions 1321b or on the reagent container 20. It is also possible that the first recess is provided on both the surface of the first clamping portion 1321b and the second clamping portion 1321c that abuts against the reagent container 20 when clamping the reagent container 20. Similarly, the same number of first protrusions are provided on the reagent container 20 to effectively prevent the reagent container 20 from slipping when transferring.

[0073] In some embodiments, Figures 7 to 9 The storage component 131 includes a support member 1311, which forms a reagent storage position. The support member 1311 includes a carrying surface for carrying the reagent container 20, and the carrying surface is formed with a second recess 21 that matches with the second protrusion 1311a at the bottom of the reagent container 20; or, the carrying surface is formed with a second protrusion that matches with the second concave portion at the bottom of the reagent container 20, that is, the second concave portion can be set on the carrying surface or at the bottom of the reagent container 20. The provision of a matching second recess or second protrusion is conducive to stabilizing the reagent container 20.

[0074] In some embodiments, during the process of transferring the reagent container 20, the three-dimensional driving device drives the clamping device 1321 to move from the second station along the second direction to the first station to clamp the side of the reagent container 20, and then the three-dimensional driving device moves upward to decouple the reagent container 20 from the matching concave and convex portions on the supporting surface, and then the three-dimensional driving device moves away from the first station along the second direction to the second station.

[0075] In some embodiments, the storage member 131 includes a support 1311, the support 1311 forms a reagent storage position, and a mixing structure 1311b is provided on the support 1311, and the mixing structure 1311b is used to mix the magnetic bead reagent in the reagent container 20 placed in the reagent storage position; the reagent supply mechanism also includes a power source 134 connected to the mixing structure 1311b, and the power source 134 provides power for the mixing mechanism to mix. The magnetic bead reagent mixing is set on the reagent storage position to prevent the magnetic bead reagent in the reagent container 20 from being deposited and hardened.

[0076] A mixing structure 1311b is provided on the support member 1311 corresponding to each reagent storage position for placing the reagent container 20, and the same power source 134 is connected to the mixing structures 1311b through the transmission member 135, and is used to drive the mixing structures 1311b to mix at the same time. Using a power source 134 to drive the mixing structures 1311b to mix at the same time is conducive to reducing the cost of the analyzer.

[0077] In some embodiments, the mixing structure 1311b includes a matching part, a connecting part and a rotating part, the connecting part is respectively connected to the matching part and the rotating part, the connecting part is rotatably connected to the supporting part, the matching part is used to match with the mixing structure 1311b on the reagent container 20, the rotating part is connected to the power source 134 through the transmission component 135, the power source 134 drives the transmission component 135 to drive the rotating part to rotate, thereby driving the entire mixing mechanism to rotate, so as to mix the magnetic bead reagent in the reagent container 20 by matching with the mixing structure 1311b on the reagent container 20.

[0078] In some embodiments, the transmission component 135 is a belt 1351, and the rotating parts of multiple mixing structures 1311b on the same horizontal plane are all connected to the belt 1351. The belt 1351 is connected to the same power source 134. The same power source 134 can drive multiple mixing structures 1311b in the same plane to rotate through the belt 1351.

[0079] In some embodiments, the transmission component 135 includes a plurality of belts 1351 and a transmission rod 1352, each belt 1351 is connected to the rotating parts of the plurality of mixing structures 1311b on a horizontal plane, each belt 1351 is connected to the same transmission rod 1352, the transmission rod 1352 is connected to the same power source 134, the power source 134 drives the transmission rod 1352 to rotate along its axis, each belt 1351 is transmission-connected at different positions of the transmission rod 1352, the belt 1351 abuts against the circumferential side of the transmission rod 1352, so that when the transmission rod 1352 rotates under the drive of the power source 134, the belt 1351 can be driven to move, and further the belt 1351 drives the rotating part to rotate, and then drives the mixing structure 1311b to rotate. Wherein, each belt 1351 corresponds to the horizontal plane of the reagent storage position.

[0080] In some embodiments, the reagent supply mechanism 13 includes a housing 136 which forms a receiving cavity. The storage member 131 and the first reagent container transfer device 132 are disposed in the receiving cavity. The first position is inside the receiving cavity, and the liquid suction position is outside the receiving cavity. The housing 136 is provided with an opening 1361, and the second reagent container transfer device 133 transfers the reagent container 20 between the first position and the liquid suction position through the opening 1361. By setting the liquid suction position outside the receiving cavity, the avoidance between the reagent dispensing mechanism and the reagent supply mechanism 13 can be realized, thereby further reducing the space occupied by the instrument.

[0081] In some embodiments, the second reagent container transfer member 133 moves linearly along the second direction, and the reagent dispensing mechanism moves linearly along the third direction. Moreover, the movement track of the second reagent container transfer member intersects and is perpendicular to the movement track of the reagent dispensing mechanism, which is beneficial to reducing the occupied area of the reagent supply mechanism 13 and the reagent dispensing mechanism on the plane, making the whole sample analyzer 10 more compact.

[0082] In some embodiments, the third direction is the horizontal direction.

[0083] In some embodiments, the third direction is the same as the first direction, the second direction is the horizontal direction and is perpendicular to the first direction. In some embodiments, after the reagent dispensing mechanism 14 sucks the reagent at the liquid suction position, it moves linearly along the third direction and then discharges it into the reaction container located at the liquid discharge position.

[0084] In some embodiments, such as Figure 10 , the storage member 131 includes at least two sub-storage members 1312 stacked in the vertical direction. The sub-storage member 131 extends along the first direction and is provided with multiple partition plates 1313 in the first direction. Multiple reagent storage positions arranged along the first direction are formed between the partition plates 1313. In some embodiments, the partition plates 1313 are integrally formed with the sub-storage member 131, which can make the gap between the reagent containers smaller, so that the reagent supply mechanism can accommodate more reagent containers.

[0085] In some embodiments, the first direction is the horizontal direction perpendicular to the vertical direction.

[0086] The following introduces the operation process of the sample analyzer 10, taking the immunoassay analyzer as an example. In addition to the sample supply mechanism 11, the sample dispensing mechanism 12, the reagent supply mechanism 13, the reagent dispensing mechanism, and the measurement mechanism mentioned above, the immunoassay analyzer further includes an incubation mechanism 16 and a magnetic separation mechanism 17. Taking a common scenario in the immunoassay analyzer as an example, the sample dispensing mechanism 12 dispenses the sample supplied by the sample supply mechanism 11 into the reaction container, and the reagent dispensing mechanism 14 dispenses the reagent supplied by the reagent supply mechanism 13 into the reaction container to form a mixture with the sample.

[0087] The process of the reagent dispensing mechanism 14 for dispensing reagents includes: the three-dimensional motion device 1322 drives the clamping device 1321 to move from the second station to the first station along the second direction. The clamping part driving mechanism 1321d of the clamping device 1321 drives the first clamping part 1321b and the second clamping part 1321c to move to clamp the reagent container 20. After the clamping device 1321 cooperates with the matching concave and convex parts on the reagent container 20, the three-dimensional motion device 1322 moves vertically upward to decouple the reagent container 20 from the matching concave and convex parts on the carrier. Then, the three-dimensional motion device 1322 moves away from the first station along the second direction to the second station. After moving to the second station, the three-dimensional motion device 1322 moves along the vertical and the first direction to the liquid suction level or the first position. If it moves to the liquid suction level, the reagent dispensing mechanism sucks liquid at the liquid suction level; if it moves to the first position, the second reagent container device transfers the reagent container 20 transferred to the first position by the three-dimensional motion device 1322 to the liquid suction level, and the reagent dispensing mechanism sucks liquid at the liquid suction level.

[0088] After the reagent and the sample are dispensed, the mixture of the reagent and the sample is transferred to the incubation mechanism 16 for incubation. After the incubation is completed, the mixture of the sample and the reagent is magnetically separated and cleaned in the magnetic separation mechanism 17. After the magnetic separation cleaning is completed, a signal reagent is added, and finally the measurement mechanism 15 performs the measurement.

[0089] Embodiment 2:

[0090] The sample analyzer 10 provided in this embodiment is mainly different from that in Embodiment 1 in that the arrangement of the storage members 131 is different. Specifically, in Embodiment 1, the storage members 131 are arranged along the vertical direction and the first direction. In this embodiment, the storage members 131 are arranged along the first horizontal direction and the second horizontal direction, and at the same time, the three-dimensional motion device is adaptively changed.

[0091] Specifically, in this embodiment, as Figure 1 and Figure 11 , the sample analyzer 10 includes: a sample supply mechanism for supplying samples; a sample dispensing mechanism 12 for dispensing samples into reaction cups; a reagent supply mechanism 13 for supplying reagents; a reagent dispensing mechanism for sucking the reagent in the reagent container 20 at the liquid suction level and discharging the sucked reagent into the reaction cup at the discharge liquid level; a measurement mechanism for measuring the test liquid made of at least the sample and the reagent in the reaction cup to obtain a measurement result.

[0092] Among them, the reagent supply mechanism 13 includes: a storage member 131 provided with a plurality of reagent storage positions for placing reagent containers 20, the plurality of reagent storage positions are arranged along a first horizontal direction, at least two reagent storage positions are arranged along a second horizontal direction, and the first horizontal direction is different from the second horizontal direction; a third reagent container transfer device 137 for transferring the reagent container 20 stored in the reagent storage position to the liquid suction position, or a third reagent container transfer device 137 and a fourth reagent container transfer device, the third reagent container transfer device 137 is used to transfer the reagent container stored in the reagent storage position of the storage member 131 to a second position, and the fourth reagent container transfer device is used to transfer the reagent container 20 between the second position and the liquid suction position; wherein, the third reagent container transfer device 137 includes a clamping device and a three-dimensional motion device, the three-dimensional motion device is connected to the clamping device and is used to drive the clamping device to move in a three-dimensional space, and the clamping device is used to clamp the reagent container 20 to grab the reagent container 20 and release the reagent container 20 to put down the reagent container 20.

[0093] In some embodiments, the first horizontal direction and the second horizontal direction are perpendicular.

[0094] The three-dimensional motion device is used to drive the clamping device to move between a third working position and a fourth working position in the vertical direction. When the three-dimensional motion device moves to the third working position, the clamping device can grab or put down the reagent container 20 on the storage position. When the three-dimensional motion device moves to the fourth working position, the three-dimensional motion device can move between the corresponding positions of each reagent storage position in the vertical direction. The second horizontal direction is different from both the first horizontal direction and the vertical direction.

[0095] In some embodiments, after the three-dimensional motion device moves from the third working position to the fourth working position in the vertical direction, it then moves along the second horizontal direction or the first horizontal direction from the fourth working position. The corresponding position refers to a fourth working position corresponding to each reagent storage position.

[0096] When the three-dimensional motion device is located at the third working position, the clamping device is located outside the projection area of the reagent storage position in the horizontal direction; when the three-dimensional motion device is located at the fourth working position, at least a part of the clamping device is located within the projection area of the reagent storage position in the horizontal direction.

[0097] The above are only the preferred embodiments of the present invention, and do not limit the patent scope of the present invention accordingly. Any equivalent structural transformation made under the inventive concept of the present invention by using the content of the specification and drawings of the present invention, or directly / indirectly applied in other related technical fields, is included in the patent protection scope of the present invention.

Claims

1. A sample analyzer, characterized in that, Comprising: A sample supply mechanism for supplying samples; A sample dispensing mechanism for dispensing samples into reaction cups; A reagent supply mechanism for supplying reagents; A reagent dispensing mechanism for sucking reagents from a reagent container at a suction level and discharging the sucked reagents into a reaction cup at a discharge level; A measurement mechanism for measuring a test solution formed at least by the sample and the reagent in the reaction cup to obtain a measurement result; Wherein, the reagent supply mechanism includes: A storage member provided with a plurality of reagent storage positions for placing reagent containers, the plurality of reagent storage positions being arranged in a first direction, and at least two reagent storage positions being stacked in the vertical direction, the first direction being different from the vertical direction; A first reagent container transfer device for transferring the reagent container stored in the reagent storage position to the suction level, or, a first reagent container transfer device and a second reagent container transfer device, the first reagent container transfer device for transferring the reagent container stored in the reagent storage position to a first position, and the second reagent container transfer device for transferring the reagent container between the first position and the suction level; Wherein, the first reagent container transfer device includes a clamping device and a three-dimensional motion device, the three-dimensional motion device being connected to the clamping device and for driving the clamping device to move in three-dimensional space, the clamping device for clamping the reagent container to grasp the reagent container and releasing the reagent container to place down the reagent container.

2. The sample analyzer according to claim 1, wherein: The three-dimensional motion device is for driving the clamping device to move between a first station and a second station in a second direction; when the three-dimensional motion device moves to the first station, the clamping device can grasp or place down the reagent container on the storage position, and when the three-dimensional motion device moves to the second station, the three-dimensional motion device can move between corresponding positions of each reagent storage position in the second direction, the second direction being different from both the first direction and the vertical direction.

3. The sample analyzer according to claim 2, characterized in that, The three-dimensional motion device is further for driving the clamping device to move in the first direction and in the vertical direction, the first direction, the vertical direction and the second direction being perpendicular to each other.

4. The sample analyzer according to claim 2, wherein When the three-dimensional device is at the second station, the clamping device is located outside the projection area of the reagent storage position in the vertical direction; when the three-dimensional device is at the first station, the clamping device is at least partially located within the projection area of the reagent storage position in the vertical direction.

5. The sample analyzer according to claim 4, characterized in that, The clamping device at least includes a main body part, a first clamping part, a second clamping part and a clamping part driving mechanism, the main body part being connected to the three-dimensional motion device, the first clamping part, the second clamping part and the clamping part driving mechanism all being connected to the main body part, the clamping part driving mechanism for driving the first clamping part and the second clamping part to move to complete clamping or releasing of the reagent container, and the first clamping part and the second clamping part abutting against the side surface of the reagent container when clamping the reagent container.

6. The sample analyzer according to claim 5, wherein, A first convex portion is provided on the abutting portion of at least one of the first clamping portion and the second clamping portion for abutting against the reagent container, and the first convex portion is used to cooperate with a first concave portion provided on the reagent container to clamp the reagent container when clamping the reagent container; or a first concave portion is provided on the abutting portion of at least one of the first clamping portion and the second clamping portion for abutting against the reagent container, and the first concave portion is used to cooperate with the first convex portion provided on the reagent container to clamp the reagent container when clamping the reagent container.

7. The sample analyzer according to claim 1, characterized in that, The storage component includes a support member, which forms the reagent storage position, and the support member includes a carrying surface for carrying the reagent container, the carrying surface is formed with a second convex portion that matches with a second concave portion at the bottom of the reagent container; or, a second concave portion that matches with the second convex portion at the bottom of the reagent container.

8. The sample analyzer according to claim 1, characterized in that, The storage component comprises a support member, the support member forms the reagent storage position, and a mixing structure is arranged on the support member, the mixing structure is used to mix the magnetic bead reagent in the reagent container placed in the reagent storage position; The reagent supply mechanism also includes a power source that is transmission-connected to the mixing structure, and the power source provides power for the mixing mechanism to perform mixing.

9. The sample analyzer according to claim 8, characterized in that, The mixing structure is provided on the support member corresponding to each of the reagent storage positions for placing reagent containers, and the same power source is connected to the mixing structures through a transmission component to drive the mixing structures to mix simultaneously.

10. The sample analyzer according to claim 1, characterized in that, The reagent supply mechanism includes a shell, which forms a accommodating cavity. The storage component and the first reagent container transfer device are arranged in the accommodating cavity. The first position is located inside the accommodating cavity, and the liquid aspiration position is located outside the accommodating cavity. The shell is provided with an opening, and the second reagent container transfer device transfers the reagent container between the first position and the liquid aspiration position through the opening.

11. The sample analyzer according to claim 10, characterized in that, The second reagent container transfer component performs linear motion along the second direction, the reagent dispensing mechanism performs linear motion along the third direction, and a motion trajectory of the second reagent container transfer component intersects and is perpendicular to a motion trajectory of the reagent dispensing mechanism.

12. The sample analyzer according to claim 1, characterized in that, The storage component includes at least two sub-storage components stacked in a vertical direction, the sub-storage components extend along a first direction and are provided with a plurality of partitions in the first direction, and a plurality of reagent storage locations arranged along the first direction are formed between the partitions.

13. The sample analyzer according to claim 1, characterized in that, The first direction is a horizontal direction perpendicular to the vertical direction.

14. A sample analyzer, characterized in that, include: A sample supply mechanism, used for supplying samples; A sample dispensing mechanism, used for dispensing samples into reaction cups; A reagent supply mechanism, used for supplying reagents; The reagent dispensing mechanism is used to absorb the reagent in the reagent container located at the liquid aspiration position and discharge the absorbed reagent into the reaction cup located at the liquid discharge position; A measuring mechanism, used for measuring the test liquid made of at least the sample and the reagent in the reaction cup to obtain a measurement result; Wherein, the reagent supply mechanism comprises: Storage member, provided with a plurality of reagent storage positions for placing reagent containers, the plurality of reagent storage positions are arranged along a first horizontal direction, and at least two reagent storage positions are arranged along a second horizontal direction, the first horizontal direction being different from the second horizontal direction; Third reagent container transfer device, the third reagent container transfer device is used to transfer the reagent container stored in the reagent storage position to the liquid suction position, or, the third reagent container transfer device and the fourth reagent container transfer device, the third reagent container transfer device is used to transfer the reagent container stored in the reagent storage position of the storage member to a second position, and the fourth reagent container transfer device is used to transfer the reagent container between the second position and the liquid suction position; Wherein, the third reagent container transfer device includes a clamping device and a three-dimensional motion device, the three-dimensional motion device is connected to the clamping device and is used to drive the clamping device to move in three-dimensional space, and the clamping device is used to clamp the reagent container to grab the reagent container and release the reagent container to put down the reagent container.

15. The sample analyzer according to claim 14, characterized in that, The three-dimensional motion device is used to drive the clamping device to move between a third working position and a fourth working position in the vertical direction. When the three-dimensional motion device moves to the third working position, the clamping device can grab or put down the reagent container on the storage position. When the three-dimensional motion device moves to the fourth working position, the three-dimensional motion device can move between the corresponding positions of each reagent storage position in the vertical direction.

16. The sample analyzer according to claim 15, characterized in that, When the three-dimensional motion device is located at the third working position, the clamping device is located outside the projection area of the reagent storage position in the horizontal direction; when the three-dimensional motion device is located at the fourth working position, at least part of the clamping device is located within the projection area of the reagent storage position in the horizontal direction.

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