Edible dietary fiber hydrogel with function of preventing and improving fatty liver and production process thereof

Abstract

The invention belongs to the field of food processing, and particularly relates to edible dietary fiber hydrogel with a function of preventing and improving a fatty liver and a production process of the dietary fiber hydrogel. The dietary fiber hydrogel comprises the following components: 0.5 to 50 parts of psyllium husk powder premix, 0.5 to 50 parts of konjaku flour, 0.5 to 2.5 parts of carrageenan, 0.5 to 1 part of xanthan gum, 0.5 to 2 parts of pectin, 0.5 to 2 parts of citric acid, 0.5 to 50 parts of vital gluten, 0.5 to 50 parts of corn modified starch and 0.5 to 50 parts of white kidney bean powder. The chia seed beverage is prepared from the following raw materials in parts by weight: 0.5-10 parts of chia seeds, 0.1-1 part of erythritol, 0.1-1 part of stevioside, 0.1-1 part of mogroside, 0.1-1 part of xylitol and 50-200 parts of water. The dietary fiber hydrogel is proved to have the effect of preventing and improving the fatty liver, and has wide application prospects and practical value.

Description

Technical Field

[0001] The invention belongs to the field of food processing, and specifically relates to an edible dietary fiber hydrogel with the function of preventing and improving fatty liver and a production process thereof. Background Art

[0002] Fatty liver is a metabolic disease caused by abnormal lipid deposition in liver cells. With the change of modern people's diet structure, sedentary life and overweight and obesity, its incidence rate is increasing, especially in the non-alcoholic fatty liver disease (NAFLD) group. Fatty liver usually has no obvious symptoms in the early stage, but it can gradually develop into fatty liver hepatitis, liver fibrosis and even cirrhosis, which has become a public health issue of global concern.

[0003] The inventor disclosed a low-calorie edible hydrogel in CN113854579B. The hydrogel uses a premix of psyllium husk powder as a raw material, can enhance satiety, reduce sugar intake, and is particularly suitable for people with high fat and obesity. The inventor also disclosed the role of the hydrogel in sobering up in CN113854578B. Based on the previous work, the inventor further found that the hydrogel can also be used to prevent and / or improve fatty liver, which is an effect that has not been reported before. Summary of the invention

[0004] The present invention aims to provide an edible dietary fiber hydrogel with the function of preventing and improving fatty liver, which can prevent the formation of fatty liver and improve the symptoms of existing fatty liver.

[0005] To achieve the above objectives, the present invention adopts the following technical solutions.

[0006] The invention provides an edible dietary fiber hydrogel with the function of preventing and improving fatty liver. The dietary fiber hydrogel comprises the following components: 0.5-50 parts of psyllium husk powder premix, 0.5-50 parts of konjac flour, 0.5-2.5 parts of carrageenan, 0.5-1 parts of xanthan gum, 0.5-2 parts of pectin, 0.5-2 parts of citric acid, 0.5-50 parts of gluten powder, 0.5-50 parts of corn modified starch, 0.5-50 parts of white kidney bean powder, 0.5-10 parts of chia seeds, 0.1-1 parts of erythritol, 0.1-1 parts of stevioside, 0.1-1 parts of mogroside, 0.1-1 parts of xylitol and 50-200 parts of water; wherein the psyllium husk powder premix is ​​obtained by mixing the psyllium husk powder after dry powder grinding and wet powder grinding by ultrafine grinding technology.

[0007] Furthermore, the preparation steps of the psyllium husk powder premix include:

[0008] (1) taking psyllium husk powder, using ultrafine grinding technology, and adopting dry powder grinding method to obtain micron-grade psyllium husk powder;

[0009] (2) taking psyllium husk powder, and using ultrafine grinding technology to process the psyllium husk powder in nanometer scale by wet powder grinding;

[0010] (3) The micron-grade psyllium husk powder and the nano-grade processed psyllium husk powder are fully mixed in a ratio of 1:10-10:1 to obtain a psyllium husk powder premix.

[0011] Furthermore, the particle size of the grinding balls used in the dry powder pulverization method in step (1) is 5mm:3mm:1mm=300:150:200, the ball-to-material volume ratio is 2:1, the pulverization time is 1h-2h, and the rotation speed is 350r / min.

[0012] Furthermore, the wet powder pulverization method in step (2) uses grinding balls with a particle size of 0.6-0.8 mm, a ball-to-material volume ratio of 7:3, a pulverization time of 1 h-2 h, a rotation speed of 1350 r / min, a working temperature of 40-65° C., and water as the dispersant.

[0013] The dietary fiber hydrogel of the invention comprises psyllium husk and chia seeds.

[0014] Psyllium husk is rich in colloid, which is composed of arabinose, xylose, galacturonic acid, semi-dried fatty oil and a small amount of aucubine. The dietary fiber content in psyllium husk is more than 80%, while the fiber content in other fiber-rich grains such as oat and wheat bran is only 15% and 10% respectively; other nutrients mainly include glucosides, proteins, polysaccharides, vitamin B1 and choline. Soluble psyllium fiber is used in health drinks, ice cream, bread, biscuits, cakes, jams, instant noodles, cereal breakfast, etc., which can increase the fiber content or food expansion.

[0015] The micron-sized psyllium husk powder produced by dry powder grinding using ultrafine grinding technology has a larger specific surface area and a delicate taste. The nano-sized psyllium husk powder produced by wet powder grinding using ultrafine grinding technology has a significantly higher content of soluble dietary fiber (SDF).

[0016] At the same time, dietary fiber hydrogels include chia seeds. The soluble dietary fiber in chia seeds can be dissolved in water, and after absorbing water and swelling, it forms a gelatinous substance. After soaking and eating, it can have a strong sense of fullness, continuous energy supply, and bowel-moistening and laxative effects without causing any adverse allergic reactions, anti-nutritional and toxic effects. Chia seeds can also maintain a sense of fullness and play a role in weight loss by inhibiting intestinal peristalsis and delaying the excretion of food.

[0017] The present invention further discovers that the edible dietary fiber hydrogel containing the above components also has excellent preventive and ameliorative effects on fatty liver, including non-alcoholic fatty liver, which is an effect not reported before.

[0018] Therefore, the present invention provides the application of the edible dietary fiber hydrogel as described herein in the preparation of articles for preventing and / or ameliorating fatty liver.

[0019] Furthermore, the articles include foods.

[0020] Furthermore, the fatty liver includes non-alcoholic fatty liver.

[0021] The present invention also provides a preparation process of an edible dietary fiber hydrogel having the functions of preventing and ameliorating fatty liver, which comprises the following steps:

[0022] (1) Mix 0.5 - 50 parts of fresh psyllium husk, 0.5 - 50 parts of konjac powder, 0.5 - 2.5 parts of carrageenan, 0.5 - 1 part of xanthan gum, 0.5 - 2 parts of pectin, 0.5 - 2 parts of citric acid, 0.5 - 50 parts of gluten, 0.5 - 50 parts of modified corn starch, and 0.5 - 50 parts of white kidney bean powder evenly, and add 1 - 100 parts of sterile water to swell and dissolve to obtain a uniformly colored mixed colloidal substance;

[0023] (2) Dissolve 0.1 - 1 part of erythritol, 0.1 - 1 part of stevioside, 0.1 - 1 part of mogroside, and 0.1 - 1 part of xylitol mixture in 50 - 100 parts of sterile water, add the obtained mixed solution to the mixed colloidal substance at a volume ratio of 12:1 and boil over medium heat for 10 min - 30 min, continuously stir and slowly add 0.5 - 50 parts of egg white or skimmed milk, and fully mix to obtain a formed gel liquid;

[0024] (3) Filter the gel liquid obtained in the previous step to remove the foam and insoluble substances generated during the boiling process to obtain a filtrate, and repeat the above operation 2 - 3 times;

[0025] (4) Naturally cool the gel liquid to 60 - 80 °C, add a citric acid solution, and stir until evenly mixed;

[0026] (5) Sterilize the mixed gel liquid obtained in step (4) and then naturally cool it to room temperature to obtain the product.

[0027] Furthermore, the sterilization includes sterilizing at 85 °C for 5 - 10 min by pasteurization.

[0028] The beneficial effects of the present invention are as follows: the edible hydrogel prepared by using micron-grade psyllium husk powder obtained by dry powder grinding using ultrafine grinding technology and nano-grade psyllium husk powder obtained by wet powder grinding as raw materials can prevent the formation of fatty liver and improve the symptoms of existing fatty liver. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The results of Oil Red O staining of liver tissue of mice fed with normal diet, alcohol diet, and alcohol diet + hydrogel for 4 weeks, 6 weeks, and 8 weeks, respectively, are shown.

[0030] Figure 2 The results of Oil Red O staining of liver tissue of mice fed with normal diet, high-fat and high-sugar diet, and high-fat and high-sugar diet + hydrogel for 8 weeks are shown.

[0031] Figure 3 The results of Oil Red O staining of liver tissues of db / db mice not fed with hydrogel and fed with hydrogel for 8 weeks are shown. DETAILED DESCRIPTION

[0032] The present invention is further described below with reference to specific examples, but the examples do not limit the present invention in any form. Unless otherwise specified, the reagents, methods and equipment used in the present invention are conventional reagents, methods and equipment in the art.

[0033] Example 1: Preparation of Psyllium husk powder mixture

[0034] (a) 50 g of psyllium husk powder was taken, and the powder was crushed by ultrafine grinding technology, with the particle size of the grinding balls being 5 mm:3 mm:1 mm=300:150:200, the volume ratio of the balls to the materials being 2:1, the crushing time being 1 h-2 h, the rotation speed being 350 r / min, to obtain micron-grade psyllium husk powder, which was the first-grade material;

[0035] (b) taking 10 g of psyllium husk powder, using ultrafine grinding technology, adopting wet powder grinding method, grinding ball particle size of 0.6-0.8 mm, ball-to-material volume ratio of 7:3, grinding time of 1h-2h, rotation speed of 1350r / min, working temperature of 40-65°C, dispersant of water, obtaining nano-scale processed psyllium husk powder as secondary powder, drying and standby;

[0036] (c) The first-level powder and the second-level powder of the ultrafinely crushed psyllium husk powder raw material are fully mixed in a ratio of 1:1 to obtain a psyllium husk powder premix.

[0037] Example 2: Preparation of edible hydrogel

[0038] (1) 10 parts of fresh psyllium husk are mixed with 2 parts of konjac flour, 2.5 parts of carrageenan, 1 part of xanthan gum, 2 parts of pectin, 2 parts of citric acid, 3 parts of gluten, 1 part of modified corn starch, and 1 part of white kidney bean flour, and mechanically stirred to be uniform, and then soaked in 100 parts of sterile water and stirred slowly until it absorbs water and swells, and then slowly heated over low heat to allow it to fully swell and dissolve, and after 20 minutes, a mixed gel-like substance with uniform color is formed, which is left to stand for use;

[0039] (2) Dissolve 1 part of erythritol, 1 part of stevia, 1 part of mogroside and 1 part of xylitol mixture (flavoring agent) in 200 parts of sterile water, stir under low heat to obtain a mixed solution, add the prepared solution to the mixed gelatinous substance at a ratio of 12:1 and cook over medium heat for 10 minutes, continue stirring and slowly add 10 parts of egg white, and mix thoroughly to obtain a formed gel solution;

[0040] (3) Take the gel solution obtained in the previous step and slowly pour it into the filter to filter out the foam and insoluble matter generated during the boiling process to obtain a filtrate, and repeat the above operation 2-3 times;

[0041] (4) Cool the gel solution naturally for 20 minutes until it reaches about 70°C, add 7% citric acid solution, and stir until the mixture is uniform;

[0042] (5) sterilizing the cooled mixed gel solution at 85° C. for 5-10 minutes by pasteurization;

[0043] (6) The semi-finished product is allowed to continue to cool naturally to room temperature and then packaged to obtain the finished product.

[0044] Example 3: Effect of hydrogel in preventing alcoholic fatty liver disease

[0045] Adult male C57BL / 6 mice (22±2g) aged 8 weeks were randomly divided into 3 groups, each with 10 mice, namely, a normal feed group, an alcohol feed group, and an alcohol feed + hydrogel group. The C57BL / 6 mice were first fed with a normal liquid feed for 7 days. Then, the alcohol feed group was fed with Lieber-DeCarli liquid alcohol feed, and the alcohol feed + hydrogel group was fed with Lieber-DeCarli liquid alcohol feed and the edible hydrogel prepared in Example 2. Fresh liver tissues of mice in each group were obtained after 4 weeks, 6 weeks, and 8 weeks, respectively, and Oil Red O staining was performed. The results are shown in FIG. Figure 1 As shown, it can be seen that with the feeding of alcohol feed, the alcohol feed group showed obvious liver fatty lesions, while the degree of liver fatty lesions in the alcohol feed + hydrogel group was significantly weaker than that in the alcohol feed group, indicating that the hydrogel of the present invention can prevent the formation of alcoholic fatty liver.

[0046] Example 4: Effect of hydrogel in preventing and treating non-alcoholic fatty liver disease

[0047] Eight-week-old adult male C57BL / 6 mice (22 ± 2 g) were randomly divided into three groups of 10 mice each: a normal diet group, a high-fat (30% lard diet) and high-sugar (15% fructose) diet group, and a high-fat and high-sugar diet + hydrogel group. The C57BL / 6 mice were first fed a normal diet for 7 days for adaptation, and then fed according to the experimental groups. After 8 weeks, fresh liver tissues of the mice in each group were prepared for Oil Red O staining. The results are as Figure 2 shown. It can be seen that after feeding with the high-fat and high-sugar diet, obvious liver steatosis occurred in the high-fat and high-sugar diet group, while almost no liver steatosis occurred in the high-fat and high-sugar diet + hydrogel group, indicating that the hydrogel of the present invention can prevent the formation of non-alcoholic fatty liver.

[0048] Db / db mice with severe liver fat accumulation and fatty liver are commonly used mouse models in basic diabetes research and clinical drug development, and are classic models for the scientific community to study diabetes. As Figure 3 shown, db / db mice were divided into two groups: a control group and a hydrogel group. The hydrogel was fed for a total of 8 weeks. Fresh liver tissues of the mice in each group were prepared for Oil Red O staining. The results showed that after feeding with the hydrogel, the reversal of liver fat accumulation occurred, indicating that the hydrogel of the present invention can improve fatty liver.

[0049] It should be noted that the description and drawings of the present invention give preferred embodiments of the present invention. However, the present invention can be implemented in many different forms and is not limited to the embodiments described in this specification. These embodiments do not serve as additional limitations to the content of the present invention. The purpose of providing these embodiments is to make the understanding of the disclosed content of the present invention more thorough and comprehensive. Further, the above technical features continue to be combined with each other to form various embodiments not listed above, which are all regarded as within the scope described in the description of the present invention. Further, for those of ordinary skill in the art, improvements or changes can be made according to the above description, and all such improvements and changes should fall within the protection scope of the appended claims of the present invention.

Claims

1. Use of an edible dietary fiber hydrogel in the preparation of an article for preventing and / or improving fatty liver, characterized in that, The ingredients of the dietary fiber hydrogel include: 0.5-50 parts of psyllium husk powder premix, 0.5-50 parts of konjac flour, 0.5-2.5 parts of carrageenan, 0.5-1 parts of xanthan gum, 0.5-2 parts of pectin, 0.5-2 parts of citric acid, 0.5-50 parts of gluten, 0.5-50 parts of corn modified starch, 0.5-50 parts of white kidney bean powder, 0.5-10 parts of chia seeds, 0.1-1 parts of erythritol, 0.1-1 parts of stevioside, 0.1-1 parts of mogroside, 0.1-1 parts of xylitol and 50-200 parts of water; The preparation steps of the psyllium husk powder premix include: (1) taking psyllium husk powder, using ultrafine grinding technology, and adopting dry powder grinding method to obtain micron-grade psyllium husk powder; (2) taking psyllium husk powder, and using ultrafine grinding technology to process the psyllium husk powder in nanometer scale by wet powder grinding; (3) The micron-grade psyllium husk powder and the nano-grade processed psyllium husk powder are fully mixed in a ratio of 1:10-10:1 to obtain a psyllium husk powder premix.

2. The application according to claim 1, characterized in that, The dry powder pulverization method in step (1) uses grinding balls with a particle size of 5 mm: 3 mm: 1 mm = 300: 150: 200, a ball-to-material volume ratio of 2: 1, a pulverization time of 1 h-2 h, and a rotation speed of 350 r / min.

3. The application according to claim 1, wherein The wet powder pulverization method in step (2) uses grinding balls with a particle size of 0.6-0.8 mm, a ball-to-material volume ratio of 7:3, a pulverization time of 1 h-2 h, a rotation speed of 1350 r / min, a working temperature of 40-65 ° C, and a dispersant of water.

4. The application according to claim 1, wherein The preparation process of the edible dietary fiber hydrogel comprises the following steps: (1) 0.5-50 parts of fresh psyllium husk, 0.5-50 parts of konjac flour, 0.5-2.5 parts of carrageenan, 0.5-1 parts of xanthan gum, 0.5-2 parts of pectin, 0.5-2 parts of citric acid, 0.5-50 parts of gluten, 0.5-50 parts of modified corn starch, and 0.5-50 parts of white kidney bean powder are mixed evenly, and 1-100 parts of sterile water is added to swell and dissolve to obtain a mixed colloid substance with uniform color; (2) dissolving 0.1-1 part of erythritol, 0.1-1 part of stevia, 0.1-1 part of mogroside and 0.1-1 part of xylitol in 50-100 parts of sterile water, adding the obtained mixed solution to the mixed colloid substance in a volume ratio of 12:1 and boiling over medium heat for 10 min-30 min, stirring continuously and slowly adding 0.5-50 parts of egg white or skim milk, and mixing thoroughly to obtain a formed gel solution; (3) Filter the gel solution obtained in the previous step to remove the foam and insoluble matter generated during the boiling process to obtain a filtrate, and repeat the above operation 2-3 times; (4) Cooling the gel solution naturally to 60-80° C., adding citric acid solution, and stirring until the mixture is uniform; (5) The mixed gel solution obtained in step (4) is sterilized and naturally cooled to room temperature.

5. The application according to claim 4, characterized in that, The sterilization includes pasteurization at 85° C. for 5-10 minutes.

6. The application according to claim 1, characterized in that, The fatty liver includes non-alcoholic fatty liver.

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